Clinical trials led by investigators in the Center for Cognitive Neurology are designed to advance our understanding of Alzheimer’s disease and help us identify more effective treatments.

Therapeutic Trials in Alzheimer’s Disease

A Phase 2A Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Varoglutamstat (PQ912) in Patients with Early Alzheimer’s Disease with a Stage Gate to Phase 2B (VIVA-MIND)
Principal Investigator: Arjun V. Masurkar

Phase 1 Clinical Trial of Innate Immunity Stimulation via TLR9 in Early AD (Part the Cloud)
Principal Investigator: Arjun V. Masurkar

A Study to Verify the Clinical Benefit of Aducanumab in Participants with Early Alzheimer's Disease (ENVISION)
Principal Investigator: Martin Sadowski, MD, PhD

A Study to Assess if BIIB080 Can Change Clinical Dementia Rating-Sum of Boxes Scores, and BIIB080 Safety and Tolerability When Injected Into the Cerebrospinal Fluid of Participants with Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age (CELIA)
Principal Investigator: Martin Sadowski, MD, PhD

Piromelatine 20 mg in Participants With Mild Dementia Due to Alzheimer's Disease
Principal Investigator: Martin Sadowski, MD, PhD

Characterizing Alzheimer’s Disease

Alzheimer’s Disease Research Center
Principal investigator: Thomas M. Wisniewski, MD

Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI3) Protocol: ATRI-001
Principal investigator: Martin Sadowski, MD, PhD

Ongoing Clinical Trials (Not Actively Recruiting)

A Placebo-Controlled Double-Blind Parallel-Group 18 Month Study to Confirm Safety and Efficacy of BAN2401 in Subjects with Early Alzheimer’s Disease
Principal investigator: Martin Sadowski, MD, PhD

A Study of Donanemab (LY3002813) in Participants with Early Alzheimer’s Disease (TRAILBLAZER-ALZ 2)
Principal investigator: Martin Sadowski, MD, PhD

Anti-Viral Therapy in Alzheimer’s Disease
Principal investigator: Thomas M. Wisniewski, MD

Care-Partner Assisted Intervention to Improve Oral Health for Individuals with Mild Dementia
Principal investigator: Bei Wu, PhD

Phase 3 trial of oral ALZ-801 in Early AD Patients Who Are Homozygous for the Epsilon 4 Variant of the Apolipoprotein E Gene (APOE4/4)
Principal investigator: Martin Sadowski, MD, PhD

Metformin in Alzheimer’s Dementia Prevention (MAP)
Principal investigator: Arjun V. Masurkar, MD, PhD