Research

New DNA Sequencing Method Reveals How Bacteria Resist Antibiotics

A new technology can read the order, or sequence, of the “letters” making up DNA code with enough accuracy to reveal how bacteria use high-speed evolution to defeat antibiotics. That is the finding of a study led by senior author Evgeny Nudler, PhD at NYU Langone Medical Center and published in the journal Nature. The technology, called Maximum Depth Sequencing (MDS), eliminates the error introduced by core methods behind current high-speed DNA sequencing machines to catch genetic changes so rare that older methods could not tell them apart from machine error. Read more…


Breast Cancer Cells Use Newfound Pathway to Survive Low Oxygen Levels in Tumors

Researchers have identified a new signaling pathway that helps cancer cells cope with the lack of oxygen found inside tumors. These are the results of a study published in Nature Cell Biology, and led by researchers at NYULMC and its Laura and Isaac Perlmutter Cancer Center, Princess Margaret Cancer Centre, the University of Toronto, Harvard Medical School, and Oxford University. Oxygen is important for the proper function of all human cells, but cancer cells thrive even when deprived of it. Read more…