Origins of ‘Rage’ Identified in Brain in Male Animal Model

According to a report by researchers from NYU Langone Medical Center published online in the journal Current Biology, damage or lost function in the animals’ midbrain wall structure—the lateral septum—was found to trigger a cascade of activity in other brain regions that produced “septal rage.” These sudden, violent acts have long been seen in rodents with a damaged lateral septum, and in some birds, researchers say. “Our latest findings show how the lateral septum in mice plays a gatekeeping role, simultaneously ‘pushing down the brake’ and ‘lifting the foot off the accelerator’ of violent behavior,” says study senior investigator Dayu Lin, PhD. Read more….

Brain Formation Patterns in Mice Suggest How Trauma May Cause Disease But Leave No Clues

NYULMC study reveals that some of the earliest nerve cells to develop in the womb shape brain circuits that process sights and sounds, but then give way to mature networks that convert this sensory information into thoughts. Study authors from the NYU Neuroscience Institute were Gord Fishell, PhD, Sebnem Tuncdemir, PhD, Brie Wamsley, PhD, and Bernardo Rudy, MD, PhD. Published in Neuron, the results could advance the understanding of neurologic and psychiatric conditions like epilepsy and schizophrenia. Read more…