Study Shows Protein Complex Essential to Creating Healthy Blood Cells

A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis. Researchers at NYU Langone Medical Center and its Perlmutter Cancer Center say their findings, published online in the journal Cell Stem Cell, suggest that placing strict biological controls on a portion of the protein complex, known as mediator complex subunit 12, or MED12 for short, could serve as a tool for stopping a variety of cancers. Read more about this study led by Iannis Aifantis, PhD

Immune System Infighting Explains Pancreatic Cancer’s Aggression

Internal conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer. Curbing this infighting has the potential to make treatment more effective, according to researchers from NYU Langone Medical Center and its Perlmutter Cancer Center. Published in Cell, and led by George Miller, MD, the study describes how a powerful subset of immune cells, known as gamma delta T cells, prevents other tumor-fighting T cells from entering pancreatic tumors. Without interference from gamma delta T cells, CD4 and CD8 cells multiply and actively attack tumors the way they attack invading viruses or bacteria. Read more...