NYU Langone’s Cryo–Electron Microscopy Laboratory has two cryo–electron microscopes operated by our expert staff. We also have plunge freezing and cleaning systems. Additional electron microscopes suitable for negative stain or tissue sections are available in the Microscopy Laboratory.

If you need assistance operating an instrument, our technicians offer training and project consultation.

Before you reserve time on one of our instruments, you are welcome to email Bill Rice, PhD, director, at william.rice@nyulangone.org or Bing Wang, PhD, research scientist, at bing.wang@nyulangone.org to discuss how we can best assist you.

Thermo Scientific Titan/Krios G3i

• 300-kV XFEG electron source
• 3 condenser lens system for parallel illumination
• 12-sample autoloader
• Falcon 3EC direct electron detector
• Gatan Bioquantum imaging filter with a Gatan K2 Summit^® direct detection camera
• Volta phase plate

Data Collection Software

• Thermo Scientific EPU
• Thermo Scientific tomography

Thermo Scientific Talos Arctica

• 200-kV XFEG electron source
• 2 condenser lens system
• 12-sample autoloader
• Gatan K2 Summit^® direct detection camera
• Volta phase plate

Data Collection Software

• SerialEM for single particle and tomography

Validation

• proteasome structure determined at 3.6-Å resolution

Thermo Scientific Vitrobot Mark IV

• plunge freezing of samples

Leica EM GP

• plunge freezing of samples

Gatan SOLARUS Advanced Plasma Cleaning System

• glow discharge of specimen supports

PELCO easiGlow Glow Discharge Cleaning System

• glow discharge of specimen supports