Our cancer development project awardees receive funds to conduct research projects designed to advance the treatment of cancer.

2022 Developmental Projects Program Awardees

Brian D. Dynlacht, PhD, and Diane M. Simeone, MD
Identifying novel inhibitors of pancreatic tumor growth

Michelle Krogsgaard, PhD, and Jeffrey Weber, MD, PhD
The correlation between neoantigen landscape and response to Pembrolizumab in melanoma patients

Alexander Serganov, PhD, and Evgeny Nudler, PhD
Small molecule-macromolecule interactions, RNA-protein interactions, structural biology, drug q1wa-32 design

2021 Developmental Projects Program Awardees

Jane Skok, PhD
Understanding the relationship between condensin and cohesin in mitosis and postmitotic cells

Dafna Bar-Sagi, PhD, Paul E. Oberstein, MD, and Christopher Wolfgang, MD, PhD
Assessment of an exercise intervention for neo-adjuvant pancreatic cancer and impact on peripheral and intra-tumoral immunity

Neville Sanjana, PhD, and Catherine S. Diefenbach, MD
Development of novel CAR T-cell therapies for diffuse large B-cell lymphoma

Elaine Shum, MD
New York Female Asian Nonsmoker Screening Study (FANSS)

Kenneth S. Hu, MD
Phase II: Adaptive de-escalation of radiation therapy dose in HPV-positive oropharyngeal cancer

2020 Developmental Projects Program Awardees

Benjamin G. Neel, MD, PhD, and Shohei Koide, PhD
Generating and assessing immune responses to covalent anti-cancer drug target complexes

John T. Poirier, PhD, and Thales Y. Papagiannakopolous, PhD
In vivo modeling of complex lung cancer genotypes by in situ high-dose-rate (HDR) brachytherapy

Jane Skok, PhD, and Aristotelis Tsirigos, PhD
Dynamic regulation of cancer therapy resistance genes via three-dimensional contacts with non-coding regulatory elements

Jun Wang, PhD, and Alec Kimmelman, MD, PhD
Siglec-15 as a novel immune evasion mechanism for KRAS mutant pancreatic cancer

2019 Developmental Projects Program Awardees

Lorna E. Thorpe, MPH, PhD
Developing and validating model cancer surveillance measures for NYC and its neighborhoods using electronic health record data

Stacy Loeb, MD
Using a user-centered design framework to develop a tailored sleep health improvement program (SHIP) for prostate cancer patients and caregivers

Aristotelis Tsirigos, PhD
Integrated characterization of histological and molecular tumor heterogeneity using deep learning

Itai Yanai, PhD, and Jeffrey S. Weber, MD, PhD
Building a human melanoma atlas for personalized immunotherapy treatment

Theodore H. Welling, MD, and Itai Yanai, PhD
Therapeutic targeting of tumor-associated macrophages in hepatocellular carcinoma

2018 Developmental Projects Program Awardees

Ken H. Cadwell, PhD and Jeffrey S. Weber, MD, PhD
Role of enteric virome on immune-checkpoint blockade efficacy and toxicity

Stella S. Yi, MPH, PhD, Ophira M. Ginsburg, MD, and Mary E. Northridge, MPH, PhD
Prevention of HPV-related cancer disparities through chairside screening and vaccination referral

2017 Developmental Projects Program Awardees

Michael E. Pacold, MD, PhD, and Diane M. Simeone, MD
Targeting lipoic acid–dependent metabolism in pancreatic cancer

Evgeny A. Nudler, PhD
Using maximum-depth sequencing for liquid biopsy detection of lung cancer