Researchers in NYU Langone’s Department of Obstetrics and Gynecology conduct clinical trials on topics such as chemical exposures and nutrition in pregnancy, fetal monitoring, postmenopausal health, contraception, overactive bladder in women, and gynecologic cancers.

Family Planning Clinical Studies

Researchers in the Division of Family Planning are conducting clinical studies on contraception.

NES-E2 Contraceptive Vaginal Ring: Study of Efficacy, Cycle Control, and Safety

Siripanth Nippita, MD, is comparing the safety and efficacy of cyclical use of a Nestorone^® and estradiol (NES-E2 CVR) vaginal ring with continuous use. See full trial information.

Study Comparing Emergency Contraception Effectiveness in Women Who Weigh at Least 80 kg

Dr. Nippita is comparing the efficacy of ulipristal acetate with that of levonorgestrel as emergency contraception in obese women. See full trial information.

Female Pelvic Medicine and Reconstructive Surgery Clinical Trials

Researchers in the Division of Female Pelvic Medicine and Reconstructive Surgery are collaborating with the Department of Urology on several trials.

Efficacy Posterior Tibial Nerve Stimulation with Sham Treatment for Bladder Pain Syndrome

Benjamin M. Brucker, MD, is comparing posterior tibial nerve stimulation with a sham treatment in women with bladder pain syndrome, or interstitial cystitis. See full trial information.

Overactive Bladder Voiding Diary and Urodynamics Correlation Study

Researchers are identifying the strongest correlations between the use of overactive bladder voiding diaries and data from urodynamics studies. See full trial information.

Postmenopausal Health Clinical Studies

Our investigators study ways to improve women’s postmenopausal health.

Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similar Hormones

Lila Nachtigall, MD is evaluating a topical cream containing green tea extract for the relief of vulvar pain in postmenopausal women who are not taking estrogen or similar hormones. See full trial information.

Maternal–Fetal Medicine Clinical Studies

Researchers in the Division of Maternal–Fetal Medicine and elsewhere within the department conduct clinical trials to improve the health of pregnant women and their babies.

Environmental Influences on Child Health Outcomes (ECHO)

Shilpi S. Mehta-Lee, MD, and Sara G. Brubaker, MD, through the NYU Pediatric Obesity, Metabolism, and Kidney Cohort Center, are conducting the Environmental Influences on Child Health Outcomes (ECHO) study. This seven-year study is evaluating pre-, peri-, and postnatal chemical exposures on pediatric health outcomes. See full trial information.

SNP-Based Microdeletion and Aneuploidy RegisTry

As part of the multicenter SNP-Based Microdeletion and Aneuploidy RegisTry (SMART), Ashley S. Roman, MD, is investigating a noninvasive, single nucleotide polymorphism–based prenatal screening test for detecting DiGeorge syndrome. See full trial information.

Effects of Diet on Pregnancy Outcome and Child Obesity

Bruce K. Young, MD, is assessing the effects of two different diets on pregnancy outcomes and weight gain in mothers and their babies. Researchers provide online continuing education, diet guidelines, and recipes to help reinforce nutritional goals and encourage patient compliance. See full trial information.

In collaboration with Rutgers University scientists, researchers are also studying pregnancy-related and diet-related changes in patients’ microbiome. With researchers in Gothenburg, Sweden, we are investigating how diet affects blood levels of biomarkers associated with whole grain intake.

Gynecologic Oncology Clinical Trials

Researchers in the Division of Gynecologic Oncology, in collaboration with NYU Langone’s Perlmutter Cancer Center—a National Cancer Institute–designated Comprehensive Cancer Center—conduct clinical trials in ovarian, cervical, and uterine cancers.

Multigene Panel Testing in Ovarian Cancer

Division researchers are evaluating the feasibility of genetic counseling in newly diagnosed patients with ovarian, fallopian tube, or peritoneal cancer. See full trial information.

An Open-Label Randomized Phase 3 Clinical Trial of REGN2810 Versus Therapy of Investigator’s Choice Chemotherapy in Recurrent or Metastatic Platinum-Refractory Cervical Carcinoma

Leslie R. Boyd, MD, is studying an investigational immunotherapy drug, REGN2810, in women with recurrent or metastatic platinum-refractory cervical cancer. See full trial information.

A Randomized Phase II Trial of Radiation Therapy and Cisplatin Alone or in Combination with Intravenous Triapine in Women with Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, or IVA Cancer of the Uterine Cervix or Stage II to IVA Vaginal Cancer

Dr. Boyd is investigating the radiation sensitizer triapine combined with radiation therapy and chemotherapy in women with locally advanced cervical or vaginal cancer. See full trial information.

A Phase I Dose Escalation and Cohort Expansion Study of TSR-042, an Anti–PD-1 Monoclonal Antibody, in Patients with Advanced Solid Tumors

Bhavana Pothuri, MD, is studying the new immunotherapy drug TSR-042 in women with recurrent or advanced endometrial cancer. See full trial information.

A Phase III Multicenter Randomized, Placebo Controlled Study of Atezolizumab Versus Placebo in Combination with Paclitaxel, Carboplatin, and Bevacizumab for Patients with Newly Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Dr. Pothuri is assessing the immunotherapy drug atezolizumab combined with chemotherapy and antiangiogenic therapy for the treatment of ovarian, fallopian tube, or primary peritoneal cancer. See full trial information.