The complexity and regulation of the subcellular localization of signaling molecules allows for a broader repertoire of functional output.
Our focus: how the trafficking of small GTPases relates to their function.
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The K-Ras farnesyl-electrostatic switch…
The localization of K-Ras is regulated by a farnesyl-electrostatic that is activated by phosphorylation by PKC of serine 181 of K-Ras. Moreover, phosphorylated, internalized K-Ras engages a pro-apoptotic pathway.
Compartmentalized Ras signaling in fission yeast…
In Schizosaccharomyces pombe, whereas Ras1 at the plasma membrane regulates mating through a MAPK pathway, the same GTPase regulates elongated morphology through Cdc42 when positioned on endomembrane.