Principal Investigator: Ann Marie Schmidt, MD
ANN MARIE SCHMIDT earned her B.A. in biology and history summa cum laude from NYU’s Washington Square College and her M.D. degree with honors from NYU School of Medicine. She remained at NYU to complete her medical residency and chief residency, as well as fellowship in hematology and medical oncology, then moved to Columbia University, joining the department of physiology and cellular biophysics as a Post-doctoral Fellow of the Juvenile Diabetes Research Foundation (JDRF). From 2003 to 2010, she served as the Chief of the Division of Surgical Science and the Gerald and Janet Carrus Professor of Surgical Science. Effective July 1, 2010, Dr. Schmidt returned to NYU as the Director of the Diabetes Research Program at New York University Langone Medical Center, New York and the first Iven Young Professor of Endocrinology at NYU. She is a Professor of Medicine, Pharmacology and Pathology.
Dr. Schmidt’s laboratory discovered “RAGE,” (receptor for advanced glycation end-products), a cell-surface receptor that exacerbates inflammation and damage when activated, to heart disease-related vascular injury, particularly in diabetes and its complications. She has studied RAGE and its relationship to inflammatory and immune disorders, peripheral nerve injury and regeneration, and neurodegenerative diseases. Her laboratory has recently discovered the intracellular interactions of the RAGE cytoplasmic domain with diaphanous-1, a member of the formin family. This discovery forms the basis for the identification of a new class of RAGE inhibitors for the treatment of diabetes and its complications and RAGE-related disorders.
Dr. Schmidt is a Scholar of the JDRF and received the David Rumbough Research Award from the JDRF in 2010.