News & Highlights
- Vikas Bakshi is the Diabetes Research Program Researcher of the Month.
- Andisheh Abedini, PhD was awarded the Association-Wide Scientist Development Grant from the American Heart Association. The goal of the research is to define the cellular pathways that regulate RAGE-mediated beta cell defects and diabetic complications.
- Congratulations to Laura Senatus for successfully defending her PhD thesis titled “Receptor for Advanced Glycation End Products (Ager) and Diaphanous-1 (Drf1) Suppress Regression of Diabetic Atherosclerosis”.
Julia Derk was awarded a Ruth L. Kirschstein National Research Service Award (F31) from the NIH/NIA. The goal of the research is to investigate therapeutic strategies in the treatment of Alzheimer’s disease.
Ann Marie Schmidt, MD was awarded the 2016 Harrington Scholar Innovator Grant. In collaboration with Drs. Alex Shekhtman (State University of New York at Albany), David A. Antonetti, (University of Michigan), Daniel J. Ceradini (NYU Langone Medical Center) and Robert J. DeVita (RJD Medicinal Chemistry and Drug Discovery Consulting, LLC) the goal of the research is to develop therapies for diabetic retinopathy and wound healing.
Andisheh Abedini, PhD's paper, “Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics” was recently accepted by eLife.
Michaele Manigrasso, PhD's paper, "Small Molecule Inhibition of Ligand-Stimlutated RAGE-DIAPH1 Signal Transduction" was published in Scientific Reports.
Devi Thiagarajan, PhD's paper, "Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor" was recently published in Cell Reports.
Judyta Juranek, PhD and Gurdip Daffu, PhD published two papers in Frontiers in Cellular Neuroscience: "Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice" and "Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis".
- The Diabetes Research Program sends congratulations to Radha Ananthakrishnan, PhD and Gurdip Daffu, PhD. <<more>>
- Congratulations to Andisheh Abedini, PhD for her promotion to Research Assistant Professor. Effective July 1, 2015.
- Evelyn Litwinoff’s first article titled “Emerging targets for therapeutic development in diabetes and its complications: The RAGE signaling pathway” was accepted for publication by Clinical Pharmacology & Therapeutics.
- Carmen Hurtado del Pozo, PhD received the Mentor-Based Postdoctoral Minority Fellowship Award from the American Diabetes Association.
- Ann Marie Schmidt MD and Ravi Ramasamy, PhD were awarded a Collaborative Interdisciplinary Team Science in NIDDK Research Areas (R24) grant from the NIH/NIDDK. In collaboration with Dr. Alex Shekhtman at the State University of New York at Albany, Columbia University and Albany Molecular Research Inc. (AMRI), the research will focus on developing novel therapies and target engagement biomarkers for the treatment of diabetic complications. Participation of colleagues in NYU's Office of Translational Alliance (OTA) (Drs. Robert Scheider, Nadim Shohdy and Sadhana Chitale) rounds out the team of investigators in this mission.
- Dr. Ramasamy has been granted tenure by the University. Effective July 1, 2014.
- On May 14, 2014, the Department of Medicine held its 13th Annual Research Day. Among the participants were several members of the Diabetes Research Program.
- Ravi Ramasamy, PhD was awarded a shared instrumentation grant from the National Institutes of Health for the acquisition of Seahorse system. This state of the art automated system will be used to assess cellular respiration, mitochondrial properties, and glycolysis in real time. Seahorse system will be placed within the Research Support Core at NYULMC.
- On May 7, 2013, the Department of Medicine held its 12th Annual Research Day. Several members of the Diabetes Research Program participated in this event. <<more>>
- The Diabetes Research Program and NYU's Initiative in Data Science and Statistics were awarded a research grant from Independence Blue Cross. The goal of this collaboration is twofold; detect undiagnosed diabetes cases and predict potential cases of the disease. <<more>>
- Ann Marie Schmidt, MD and Ravi Ramasamy, PhD were awarded a grant from the NYU Abu Dhabi Institute. In collaboration with the NYU Abu Dhabi Public Health Research Institute, the project will examine the growing obesity and diabetes epidemic in Abu Dhabi.
- Ravi Ramasamy, PhD and Gabrielle Gold-von Simson, MD were awarded a multi-PI R25 grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIH). The grant titled “A New Era of Targeted Drug Discovery and the Path of Development” will enable NYU School of Medicine to offer a modern and innovative NIDDK-relevant course series with a multidisciplinary curriculum. This series of courses and seminars is intended to delineate how the very nature of drug development impinges upon the scientific understanding of a drug and its target(s) from its genesis at the bench through post-marketing experience and back again. The ultimate goal of this funded program is to stimulate new investigators across diverse disciplines to the field of drug development with a focus on diabetes, diabetic complications and obesity.
- Ann Marie Schmidt, MD, Ravi Ramasamy, PhD and Shi Fang Yan, MD received notice that the competitive renewal of their Program Project grant on RAGE and mechanisms of vascular dysfunction has been funded by the NHLBI. This accomplishment of the Diabetes Research Program was featured in NYULMC2.
- Mariane Abdillahi, a graduate research assistant, successfully defended her PhD thesis at Columbia University.
- Karen O’Shea, PhD, a postdoctoral fellow in Dr. Ravi Ramasamy’s lab, was awarded an F32 Postdoctoral Fellowship award by the NIH.
- Ann Marie Schmidt, MD, Ravi Ramasamy, PhD and Shi Fang Yan, MD were awarded a Multi-Project grant from the JDRF to screen for novel inhibitors of RAGE-mDia1 interaction and to dissect the role of mDia1 in diabetic complications.
- In November 2011 we published the results of our collaborative studies with Columbia University and Memorial Sloan Kettering on RAGE and massive liver resection. Our results crystallize the concept that RAGE is not primarily involved in innate immune responses; rather, RAGE perpetuates inflammatory signals that lead to excessive cellular and tissue damage. Our findings suggest that blockade of RAGE may be an effective strategy for curtailing adverse inflammation in extensive liver damage. <<more>>