Judith T Zelikoff

Biosketch / Results /

Judith T Zelikoff, Ph.D.

Professor;
Department of Environmental Medicine

Contact Info

Address
57 Old Forge Road
Floor 2 Room 235A
Sterling Forest
Tuxedo, NY 10987

845-731-3528, 845-731-5230
845-731-3528, 845-731-5230
845-351-5472
Judith.Zelikoff@nyumc.org

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Education

1982 — Dr. Zelikoff received her Ph.D. degree from the Medical School of the University of Medicine and Dentistry New Jersey, Graduate Education

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Research Summary

The major focus of my research laboratory has long been the effects of inhaled toxicants on immune system function and the reproductive process. Ongoing studies include those using inhaled nanoparticles, particulate matter (PM), cigarette smoke or its components, as well as alternative tobacco products such as gutkha and hookah.

Nanoparticles One of our main interests is studying the effects of inhaled metal nanoparticles (oxides of cadmium or silver and gold) on embryonic, fetal, and postnatal development and growth. Nanoparticles hold tremendous promise for improving our lives in areas such as medicine and allowing for cleaner energy production. However, many characteristics of materials change when used on the nano-scale (< 100 nm) and a better understanding for the potential toxic effects is needed to ensure safety of not only the end-users of these products, but also for those involved in their manufacture. For instance, we showed exposure to inhaled cadmium oxide nanoparticles during pregnancy lead to shortened body length of newborns and leads to diminished rate of weight gain early in life. The mechanisms for these actions are part of on-going studies in the laboratory. Other related studies have focused on how systemic exposure to silver nanoparticles, which may be released from the medical devices in which they are used as antimicrobial agents, can affect the immune system. These studies show that silver nanoparticles accumulate in the spleen, where they cause changes to splenic morphology as well as alter immune cell profiles, and have discovered that smaller-sized nanoparticles have a greater potential for harm than do larger ones. Particulate Matter Another focus in my laboratory is how particulate matter in air pollution causes premature birth and low birth weight. There have been many studies making this link in the epidemiologic literature with mixed results as the concentration levels, time(s) of greatest sensitivity to the placenta and developing baby, and which components of particulate matter pose the greatest harm are inconsistent in these models. We are trying to understand how exposure at different times during pregnancy can lead to premature birth/low birth weight as well as to determine the mechanisms involved and potential intervention strategies to improve the health of the baby. We have shown experimentally that exposure to PM can cause changes in the uterine environment that lead to premature birth and that timing and duration of exposure are both important factors. Tobacco Smoke and Alternative Tobacco Products A long time focus in my lab is gaining a better understand for how cigarette smoking during pregnancy affects the unborn offspring, and how these effects increase a child?s susceptibility to diseases such as cancer or heart disease later in life (i.e., developmental basis of adult disease). This model has recently evolved to include examining how smokeless or ?heat-not-burn? tobacco products can affect the reproductive process. These products, gutkha (South Asian product) and shisha smoked in a hookah (Middle Eastern product), are traditionally used by ethnic/immigrant populations, but are now being used with greater frequency by the population at large. These products, along with e-cigarettes are being studied for their toxic effects on male and female reproduction, immunity, and brain neurotransmitters which lead to addiction. Our data show that short-term exposures to gutkha is associated with decreased body weight, circulating testosterone, sperm quality and concentrations in exposed male mice as well as altered mRNA expression of important enzymes in the liver associated with biotransformation.

Research Interests

Reproductive and Developmental Toxicology Immunotoxicology Developmental Immunotoxicology Tobacco product toxicology

Research Keywords

Tobacco product immunotoxicology, Fracking, Inhaled toxicants

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Hookah use among adolescents in the United States: results of a national survey
Amrock, Stephen M; Gordon, Terry; Zelikoff, Judith T; Weitzman, Michael
2014 Feb;16(2):231-237, Nicotine & tobacco research
— id: 741352, year: 2014, vol: 16, page: 231, stat: Journal Article,

Short-term inhalation of cadmium oxide nanoparticles alters pulmonary dynamics associated with lung injury, inflammation, and repair in a mouse model
Blum, Jason L; Rosenblum, Lauren K; Grunig, Gabriele; Beasley, Mary Beth; Xiong, Judy Q; Zelikoff, Judith T
2014 Jan;26(1):48-58, Inhalation toxicology
— id: 741222, year: 2014, vol: 26, page: 48, stat: Journal Article,

A novel system to generate WTC dust particles for inhalation exposures
Vaughan, Joshua M; Garrett, Brittany J; Prophete, Colette; Horton, Lori; Sisco, Maureen; Soukup, Joleen M; Zelikoff, Judith T; Ghio, Andrew; Peltier, Richard E; Asgharian, Bahman; Chen, Lung-Chi; Cohen, Mitchell D
2014 Jan;24(1):105-112, Journal of exposure science & environmental epidemiology
— id: 741342, year: 2014, vol: 24, page: 105, stat: Journal Article,

Toxicity of gutkha, a smokeless tobacco product gone global: is there more to the toxicity than nicotine?
Willis, Daniel N; Popovech, Mary A; Gany, Francesca; Hoffman, Carol; Blum, Jason L; Zelikoff, Judith T
2014 ;11(1):919-933, International Journal of Environmental Research & Public Health
— id: 741152, year: 2014, vol: 11, page: 919, stat: Journal Article,

Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: Role of altered catecholamines and BDNF
Yochum, Carrie; Doherty-Lyon, Shannon; Hoffman, Carol; Hossain, Muhammad M; Zelikoff, Judith T; Richardson, Jason R
2014 Apr;254:145-152, Experimental neurology
— id: 836202, year: 2014, vol: 254, page: 145, stat: Journal Article,

The Smokeless Tobacco Product, Gutkha, Alters Sperm Health in Exposed Mice
Koenig, K. P.; Dougherty-Lyons, S.; Willis, D.; Hoffman, C.; Blum, J.; Gany, F.; Zelikoff, J. T.
2013 SEP;54 1 1:S50-S50, Environmental & molecular mutagenesis
— id: 540552, year: 2013, vol: 54 1 1, page: S50, stat: Journal Article,

Prenatal Exposure to Cigarette Smoke Alters Later-Life Antitumor Cytotoxic T-Lymphocyte (CTL) Activity Via Possible Changes in T-Regulatory Cells
Ng, Sheung P; Silverstone, Allen E; Lai, Zhi-Wei; Zelikoff, Judith T
2013 Jan;76(19):1096-1110, Journal of toxicology & environmental health
— id: 687802, year: 2013, vol: 76, page: 1096, stat: Journal Article,

Prenatal and early-life exposure to high-level diesel exhaust particles leads to increased locomotor activity and repetitive behaviors in mice
Thirtamara Rajamani, Keerthi; Doherty-Lyons, Shannon; Bolden, Crystal; Willis, Daniel; Hoffman, Carol; Zelikoff, Judith; Chen, Lung-Chi; Gu, Howard
2013 Aug;6(4):248-257, Autism research
— id: 516332, year: 2013, vol: 6, page: 248, stat: Journal Article,

Immune cell profiles in response to silver nanoparticles associated with medical devices
Zelikoff, Judith; Willis, Daniel; Degheidy, Heba; Zhang, Qin; Umbreit, Thomas; Goering, Peter
2013 MAY 1;190:-, Journal of immunology
— id: 540632, year: 2013, vol: 190, page: , stat: Journal Article,

Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth
Blum, Jason L; Xiong, Judy Q; Hoffman, Carol; Zelikoff, Judith T
2012 Apr;126(2):478-486, Toxicological sciences
— id: 162025, year: 2012, vol: 126, page: 478, stat: Journal Article,

Toxicology of smokeless tobacco: implications for immune, reproductive, and cardiovascular systems
Willis, Daniel; Popovech, Mary; Gany, Francesca; Zelikoff, Judith
2012 Jul;15(5):317-331, Journal of toxicology & environmental health. Pt. B. Critical reviews
— id: 174399, year: 2012, vol: 15, page: 317, stat: Journal Article,

Maternal allergy acts synergistically with cigarette smoke exposure during pregnancy to induce hepatic fibrosis in adult male offspring
Allina, Jorge; Grabowski, Jacquelin; Doherty-Lyons, Shannon; Fiel, M Isabel; Jackson, Christine E; Zelikoff, Judith T; Odin, Joseph A
2011 Oct;8(4):258-264, Journal of immunotoxicology
— id: 140522, year: 2011, vol: 8, page: 258, stat: Journal Article,

Exposure of pregnant mice to cadmium oxide (CdO) nanoparticles (NP) poses a risk to the developing offspring
Blum, J L; Hoffman, C; Xiong, J Q; Zelikoff, J T
2010 November 2010;83(1):-, Biology of reproduction
— id: 174159, year: 2010, vol: 83, page: , stat: Journal Article,

Exposure of Pregnant Mice to Cadmium Oxide (CdO) Nanopartides (NP) Poses a Risk to the Developing Offspring
Blum, Jason L.; Hoffman, Carol; Xiong, Judy Q.; Zelikoff, Judith T.
2010 NOV 23 ;122(21):115-115, Biology of reproduction
— id: 120559, year: 2010, vol: 122, page: 115, stat: Journal Article,

Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium
Cohen, Mitchell D; Sisco, Maureen; Prophete, Colette; Yoshida, Kotaro; Chen, Lung-chi; Zelikoff, Judith T; Smee, Jason; Holder, Alvin A; Stonehuerner, Jacqueline; Crans, Debbie C; Ghio, Andrew J
2010 Feb;22(2):169-178, Inhalation toxicology
— id: 105696, year: 2010, vol: 22, page: 169, stat: Journal Article,

Breaking patterns of environmentally influenced disease for health risk reduction: immune perspectives
Dietert, Rodney R; DeWitt, Jamie C; Germolec, Dori R; Zelikoff, Judith T
2010 Aug;118(8):1091-1099, Environmental health perspectives
— id: 134396, year: 2010, vol: 118, page: 1091, stat: Journal Article,

Identifying patterns of immune-related disease: use in disease prevention and management
Dietert, Rodney R; Zelikoff, Judith T
2010 May;6(2):111-118, World journal of pediatrics : WJP
— id: 134402, year: 2010, vol: 6, page: 111, stat: Journal Article,

Non-coplanar polychlorinated biphenyl (PCB)-induced immunotoxicity is coincident with alterations in the serotonergic system
Duffy-Whritenour, Jessica E; Kurtzman, Rebecca Z; Kennedy, Sarah; Zelikoff, Judith T
2010 Oct-Dec;7(4):318-326, Journal of immunotoxicology
— id: 114586, year: 2010, vol: 7, page: 318, stat: Journal Article,

Tumor challenges in immunotoxicity testing
Ng, Sheung; Yoshida, Kotaro; Zelikoff, Judith T
2010 ;598:143-155, Methods in molecular biology
— id: 105673, year: 2010, vol: 598, page: 143, stat: Journal Article,

FETAL STRESS IN UTERO PREDISPOSES TO HEPATIC FIBROSIS IN ADULT MALE B6C3F1 MICE
Allina, J; Fiel, MI; Doherty-Lyons, S; Grabowski, J; Zelikoff, JT; Odin, JA
2009 OCT ;50(4):1185A-1185A, Hepatology
— id: 105951, year: 2009, vol: 50, page: 1185A, stat: Journal Article,

Pediatric immune dysfunction and health risks following early-life immune insult
Dietert R.R.; Zelikoff J.T.
2009 ;5(1):36-51, Current Pediatric Reviews
— id: 99334, year: 2009, vol: 5, page: 36, stat: Journal Article,

Early life insult from cigarette smoke may be predictive of chronic diseases later in life
Doherty, S P; Grabowski, J; Hoffman, C; Ng, S P; Zelikoff, J T
2009 Jul;14 Suppl 1:97-101, Biomarkers
— id: 104718, year: 2009, vol: 14 Suppl 1, page: 97, stat: Journal Article,

Prenatal exposure to cigarette smoke induces diet- and sex-dependent dyslipidemia and weight gain in adult murine offspring
Ng, Sheung P; Conklin, Daniel J; Bhatnagar, Aruni; Bolanowski, Duane D; Lyon, Jessica; Zelikoff, Judith T
2009 Jul;117(7):1042-1048, Environmental health perspectives
— id: 101334, year: 2009, vol: 117, page: 1042, stat: Journal Article,

The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice
Tangjarukij, Chanthana; Navasumrit, Panida; Zelikoff, Judith T; Ruchirawat, Mathuros
2009 Sep;6(3):147-160, Journal of immunotoxicology
— id: 741362, year: 2009, vol: 6, page: 147, stat: Journal Article,

The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms
Vancza, Elizabeth M; Ng, Sheung Pui; Harkema, Jack R; Zelikoff, Judith T
2009 Jun;6(2):94-103, Journal of immunotoxicology
— id: 100669, year: 2009, vol: 6, page: 94, stat: Journal Article,

Early-life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma
Dietert, Rodney R; Zelikoff, Judith T
2008 Dec;83(6):547-560, Birth defects research. Pt B. Developmental & reproductive toxicology
— id: 94112, year: 2008, vol: 83, page: 547, stat: Journal Article,

Relationship between serotonin and the immune system in a teleost model
Duffy-Whritenour, J E; Zelikoff, J T
2008 Feb;22(2):257-264, Brain, behavior & immunity
— id: 75764, year: 2008, vol: 22, page: 257, stat: Journal Article,

The effects of prenatal exposure of mice to cigarette smoke on offspring immune parameters
Ng, Sheung P; Zelikoff, Judith T
2008 ;71(7):445-453, Journal of toxicology & environmental health. Pt. A
— id: 76347, year: 2008, vol: 71, page: 445, stat: Journal Article,

Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: vanadium agents
Cohen, Mitchell D; Sisco, Maureen; Prophete, Colette; Chen, Lung-Chi; Zelikoff, Judith T; Ghio, Andrew J; Stonehuerner, Jacqueline D; Smee, Jason J; Holder, Alvin A; Crans, Debbie C
2007 Jan;4(1):49-60, Journal of immunotoxicology
— id: 94113, year: 2007, vol: 4, page: 49, stat: Journal Article,

Detection of Changes in Alveolar Macrophage Iron Status Induced by Select PM(2.5)-Associated Components Using Iron-Response Protein Binding Activity
Doherty, S P; Prophete, C; Maciejczyk, P; Salnikow, K; Gould, T; Larson, T; Koenig, J; Jaques, P; Sioutas, C; Zelikoff, J T; Lippmann, M; Cohen, M D
2007 May;19(6):553-562, Inhalation toxicology
— id: 72616, year: 2007, vol: 19, page: 553, stat: Journal Article,

Woodsmoke health effects: a review
Naeher, Luke P; Brauer, Michael; Lipsett, Michael; Zelikoff, Judith T; Simpson, Christopher D; Koenig, Jane Q; Smith, Kirk R
2007 Jan;19(1):67-106, Inhalation toxicology
— id: 72084, year: 2007, vol: 19, page: 67, stat: Journal Article,

Smoking during pregnancy: Subsequent effects on offspring immune competence and disease vulnerability in later life
Ng, Sheung P; Zelikoff, Judith T
2007 Apr-May;23(3):428-437, Reproductive toxicology
— id: 72083, year: 2007, vol: 23, page: 428, stat: Journal Article,

Role of testosterone in gender-related enhanced tumor susceptibility of mice prenatally exposed to cigarette smoke
Steinetz, B; Ng, SP; Zelikoff, J
2007 APR ;25(3):215-215, Biology of reproduction
— id: 73248, year: 2007, vol: 25, page: 215, stat: Journal Article,

Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: chromium agents
Cohen, Mitchell D; Prophete, Colette; Sisco, Maureen; Chen, Lung-Chi; Zelikoff, Judith T; Smee, Jason J; Holder, Alvin A; Crans, Debbie C
2006 Jul 1;3(2):69-81, Journal of immunotoxicology
— id: 94114, year: 2006, vol: 3, page: 69, stat: Journal Article,

The Relationship Between Noncoplanar PCB-Induced Immunotoxicity and Hepatic CYP1A Induction in a Fish Model
Duffy, Jessica E; Zelikoff, Judith T
2006 Jan 1;3(1):39-47, Journal of immunotoxicology
— id: 94115, year: 2006, vol: 3, page: 39, stat: Journal Article,

Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke
Iba, Michael M; Fung, Jacqueline; Chung, Le; Zhao, Jason; Winnik, Bozena; Buckley, Brian T; Chen, Lung Chi; Zelikoff, Judith T; Kou, Yu Ru
2006 Jul 14;606(1-2):1-11, Mutation research
— id: 66149, year: 2006, vol: 606, page: 1, stat: Journal Article,

Effects of prenatal exposure to cigarette smoke on offspring tumor susceptibility and associated immune mechanisms
Ng, Sheung P; Silverstone, Allen E; Lai, Zhi-Wei; Zelikoff, Judith T
2006 Jan;89(1):135-144, Toxicological sciences
— id: 62363, year: 2006, vol: 89, page: 135, stat: Journal Article,

Hormonal changes accompanying cigarette smoke-induced preterm births in a mouse model
Ng, Sheung P; Steinetz, Bernard G; Lasano, Salamia G; Zelikoff, Judith T
2006 Sep;231(8):1403-1409, Experimental biology & medicine
— id: 68987, year: 2006, vol: 231, page: 1403, stat: Journal Article,

Effects of elevated temperature and nickel pollution on the immune status of Japanese medaka
Prophete, C; Carlson, E A; Li, Y; Duffy, J; Steinetz, B; Lasano, S; Zelikoff, J T
2006 Sep;21(3):325-334, Fish & shellfish immunology
— id: 66150, year: 2006, vol: 21, page: 325, stat: Journal Article,

The parity-related protection against breast cancer is compromised by cigarette smoke during rat pregnancy: observations on tumorigenesis and immunological defenses of the neonate
Steinetz, Bernard G; Gordon, Terry; Lasano, Salamia; Horton, Lori; Ng, Sheung Pui; Zelikoff, Judith T; Nadas, Arthur; Bosland, Maarten C
2006 Jun;27(6):1146-1152, Carcinogenesis
— id: 66151, year: 2006, vol: 27, page: 1146, stat: Journal Article,

PCB-induced hepatic Cyp1A induction is associated with innate immune dysfunction in a feral teleost fish
Duffy, J E; Li, Y; Zelikoff, J T
2005 Jan;74(1):107-113, Bulletin of environmental contamination & toxicology
— id: 66152, year: 2005, vol: 74, page: 107, stat: Journal Article,

Benzo[a]pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression
Carlson, E A; Li, Y; Zelikoff, J T
2004 Nov 15;201(1):40-52, Toxicology & applied pharmacology
— id: 47798, year: 2004, vol: 201, page: 40, stat: Journal Article,

Suppressive effects of benzo[a]pyrene upon fish immune function: evolutionarily conserved cellular mechanisms of immunotoxicity
Carlson, E A; Li, Y; Zelikoff, J T
2004 Aug-Dec;58(2-5):731-734, Marine environmental research
— id: 45976, year: 2004, vol: 58, page: 731, stat: Journal Article,

Application of multiple sublethal stress indicators to assess the health of fish in Pamlico Sound following extensive flooding
Adams, SM; Greeley, MS; Law, JM; Noga, EJ; Zelikoff, JT
2003 OCT ;26(5):1365-1382, Estuaries
— id: 42546, year: 2003, vol: 26, page: 1365, stat: Journal Article,

Biochemical and toxicopathic biomarkers assessed in smallmouth bass recovered from a polychlorinated biphenyl-contaminated river
Anderson, M J; Cacela, D; Beltman, D; Teh, S J; Okihiro, M S; Hinton, D E; Denslow, N; Zelikoff, J T
2003 Sep-Oct;8(5):371-393, Biomarkers
— id: 66153, year: 2003, vol: 8, page: 371, stat: Journal Article,

The role of metabolism in benzo(a)pyrene-induced immunosuppression in a fish model
Carlson, E; Li, Y; Zelikoff, JT
2003 MAR ;72(1):174-174, Toxicological sciences
— id: 38495, year: 2003, vol: 72, page: 174, stat: Journal Article,

The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans
Lippmann, Morton; Frampton, Mark; Schwartz, Joel; Dockery, Douglas; Schlesinger, Richard; Koutrakis, Petros; Froines, John; Nel, Andre; Finkelstein, Jack; Godleski, John; Kaufman, Joel; Koenig, Jane; Larson, Tim; Luchtel, Dan; Liu, L-J Sally; Oberdorster, Gunter; Peters, Annette; Sarnat, Jeremy; Sioutas, Constantinos; Suh, Helen; Sullivan, Jeff; Utell, Mark; Wichmann, Erich; Zelikoff, Judith
2003 Jun;111(8):1074-1092, Environmental health perspectives
— id: 39177, year: 2003, vol: 111, page: 1074, stat: Journal Article,

Inhalation of cadmium at a concentration associated with sidestream cigarette smoke alters antimicrobial host defense
Zelikoff, JT; Chee, G; Schermerhorn, K; Prophete, C; Cohen, MD
2003 MAR ;72(1):293-293, Toxicological sciences
— id: 38506, year: 2003, vol: 72, page: 293, stat: Journal Article,

Effects of inhaled ambient particulate matter on pulmonary antimicrobial immune defense
Zelikoff, Judith T; Chen, Lung Chi; Cohen, Mitchell D; Fang, Kaijie; Gordon, Terry; Li, Yun; Nadziejko, Christine; Schlesinger, Richard B
2003 Feb;15(2):131-150, Inhalation toxicology
— id: 34379, year: 2003, vol: 15, page: 131, stat: Journal Article,

Exposure of Japanese medaka (Oryzias latipes) to benzo[a]pyrene suppresses immune function and host resistance against bacterial challenge
Carlson, E A; Li, Y; Zelikoff, J T
2002 Mar;56(4):289-301, Aquatic toxicology
— id: 39701, year: 2002, vol: 56, page: 289, stat: Journal Article,

The Japanese medaka (Oryzias latipes) model: applicability for investigating the immunosuppressive effects of the aquatic pollutant benzo[a]pyrene (BaP)
Carlson, E A; Li, Y; Zelikoff, J T
2002 Sep-Dec;54(3-5):565-568, Marine environmental research
— id: 39571, year: 2002, vol: 54, page: 565, stat: Journal Article,

Effects of inhaled ozone on pulmonary immune cells critical to antibacterial responses in situ
Cohen, Mitchell D; Sisco, Maureen; Baker, Kathy; Li, Yun; Lawrence, David; van Loveren, Henk; Zelikoff, Judith T; Schlesinger, Richard B
2002 Jun;14(6):599-619, Inhalation toxicology
— id: 32458, year: 2002, vol: 14, page: 599, stat: Journal Article,

Impact of polychlorinated biphenyls (PCBs) on the immune function of fish: age as a variable in determining adverse outcome
Duffy, J E; Carlson, E; Li, Y; Prophete, C; Zelikoff, J T
2002 Sep-Dec;54(3-5):559-563, Marine environmental research
— id: 39572, year: 2002, vol: 54, page: 559, stat: Journal Article,

Ozone differentially modulates airway responsiveness in atopic versus nonatopic guinea pigs
Schlesinger, Richard B; Cohen, Mitchell D; Gordon, Terry; Nadziejko, Christine; Zelikoff, Judith T; Sisco, Maureen; Regal, Jean F; Menache, Margaret G
2002 May;14(5):431-457, Inhalation toxicology
— id: 34505, year: 2002, vol: 14, page: 431, stat: Journal Article,

Ozone-induced modulation of airway hyperresponsiveness in guinea pigs
Schlesinger, Richard B; Cohen, Mitchell; Gordon, Terry; Nadziejko, Christine; Zelikoff, Judith T; Sisco, Maureen; Regal, Jean F; Menache, Margaret G
2002 Jun;49(109):1-40; discussion 41, Research report (Health Effects Institute)
— id: 34490, year: 2002, vol: 49, page: 1, stat: Journal Article,

Immunotoxicity biomarkers in fish: Development, validation and application for field studies and risk assessment
Zelikoff, JT; Carlson, E; Li, Y; Raymond, A; Duffy, J; Beaman, JR; Anderson, M
2002 Feb;8(2):253-263, Human & ecological risk assessment
— id: 27522, year: 2002, vol: 8, page: 253, stat: Journal Article,

The toxicology of inhaled woodsmoke
Zelikoff, Judith T; Chen, Lung Chi; Cohen, Mitchell D; Schlesinger, Richard B
2002 Jul-Sep;5(3):269-282, Journal of toxicology & environmental health. Pt. B. Critical reviews
— id: 34503, year: 2002, vol: 5, page: 269, stat: Journal Article,

A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter
Zelikoff, Judith T; Schermerhorn, Kimberly R; Fang, Kaijie; Cohen, Mitchell D; Schlesinger, Richard B
2002 Oct;110 Suppl 5(2):871-875, Environmental health perspectives
— id: 34502, year: 2002, vol: 110 Suppl 5, page: 871, stat: Journal Article,

Ozone-induced modulation of cell-mediated immune responses in the lungs
Cohen MD; Sisco M; Li Y; Zelikoff JT; Schlesinger RB
2001 Mar 1;171(2):71-84, Toxicology & applied pharmacology
— id: 26782, year: 2001, vol: 171, page: 71, stat: Journal Article,

Cytotoxic and cytoprotective effects of selenium on bluegill sunfish (Lepomis macrochirus) phagocytic cells in vitro
Palchaudhuri S; Raymond A; Carlson EA; Li Y; Zelikoff JT
2001 Nov;67(5):672-679, Bulletin of environmental contamination & toxicology
— id: 66154, year: 2001, vol: 67, page: 672, stat: Journal Article,

Toxicology and immunotoxicology of mercury: a comparative review in fish and humans
Sweet LI; Zelikoff JT
2001 Apr-Jun;4(2):161-205, Journal of toxicology & environmental health. Pt. B. Critical reviews
— id: 66155, year: 2001, vol: 4, page: 161, stat: Journal Article,

PCBs, liver lesions, and biomarker responses in adult walleye (Stizostedium vitreum vitreum) collected from Green Bay, Wisconsin
Barron, MG; Anderson, MJ; Cacela, D; Lipton, J; Teh, SJ; Hinton, DE; Zelikoff, JT; Dikkeboom, AL; Tillitt, DE; Holey, M; Denslow, N
2000 OCT 1 ;26(3):250-271, Journal of Great Lakes research
— id: 54515, year: 2000, vol: 26, page: 250, stat: Journal Article,

Pulmonary immunotoxicology
Cohen, Mitchell D.; Schlesinger, Richard B.; Zelikoff, Judith T.
Boston, Mass. ; London : Kluwer, c2000,
— id: 710, year: 2000, vol: , page: , stat: ,

Biomarkers of immunotoxicity in fish: from the lab to the ocean
Zelikoff JT; Raymond A; Carlson E; Li Y; Beaman JR; Anderson M
2000 Mar 15;112-113:325-331, Toxicology letters
— id: 10350, year: 2000, vol: 112-113, page: 325, stat: Journal Article,

Mammalian immunoassays for predicting the toxicity of malathion in a laboratory fish model
Beaman JR; Finch R; Gardner H; Hoffmann F; Rosencrance A; Zelikoff JT
1999 Apr 23;56(8):523-542, Journal of toxicology & environmental health. Pt. A
— id: 57544, year: 1999, vol: 56, page: 523, stat: Journal Article,

Immunotoxicity biomarkers in fish: Development, validation, and application to field settings
Zelikoff, J T; Carlson, E; Li, Y; Raymond, A; Beaman, J R; Anderson, M
1999 Oct 04-06;(2293):23-23, Canadian technical report of fisheries & aquatic sciences
— id: 15826, year: 1999, vol: , page: 23, stat: Journal Article,

Profiling immunotoxicology: Chairpersons summary
Zelikoff, J T; Thomas, P T
1999 Oct 04-06;(2293):20-21, Canadian technical report of fisheries & aquatic sciences
— id: 15827, year: 1999, vol: , page: 20, stat: Journal Article,

Immunotoxicologic effects of inhaled chromium: role of particle solubility and co-exposure to ozone
Cohen MD; Zelikoff JT; Chen LC; Schlesinger RB
1998 Sep;152(1):30-40, Toxicology & applied pharmacology
— id: 7314, year: 1998, vol: 152, page: 30, stat: Journal Article,

Biomarkers of immunotoxicity in fish and other non-mammalian sentinel species: predictive value for mammals?
Zelikoff JT
1998 Aug 7;129(1):63-71, Toxicology
— id: 12065, year: 1998, vol: 129, page: 63, stat: Journal Article,

Immunotoxicology of environmental and occupational metals
Zelikoff, Judith T; Thomas, Peter T
London : Taylor & Francis, 1998,
— id: 1223, year: 1998, vol: , page: , stat: ,

Biomarker selection for restoration monitoring of fishery resources
Anderson, MJ; Barron, MG; Diamond, SA; Lipton, J; Zelikoff, JT
1997 ;1317:333-359, Fracture mechanics : proceedings of the ... National Symposium on Fracture Mechanics
— id: 589482, year: 1997, vol: 1317, page: 333, stat: Journal Article,

Effects of vanadium upon polyl:C-induced responses in rat lung and alveolar macrophages
Cohen MD; Becker S; Devlin R; Schlesinger RB; Zelikoff JT
1997 Aug 29;51(6):591-608, Journal of toxicology & environmental health
— id: 7133, year: 1997, vol: 51, page: 591, stat: Journal Article,

Pulmonary retention and distribution of inhaled chromium: Effects of particle solubility and coexposure to ozone
Cohen, MD; Zelikoff, JT; Chen, LC; Schlesinger, RB
1997 DEC ;9(9):843-865, Inhalation toxicology
— id: 53149, year: 1997, vol: 9, page: 843, stat: Journal Article,

Pulmonary and cardiovascular effects of acute exposure to concentrated ambient paniculate matter in rats
Gordon, T; Nadzieiko, C; Schlesinger, RB; Zelikoff, JT; Chen, LC
1997 ;200(4):374-375, Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine
— id: 589732, year: 1997, vol: 200, page: 374, stat: Journal Article,

Aquatic pollution-induced immunotoxicity in wildlife species
Luebke, RW; Hodson, PV; Faisal, M; Ross, PS; Grasman, KA; Zelikoff, J
1997 ;37(1):1-15, Toxicological sciences
— id: 589352, year: 1997, vol: 37, page: 1, stat: Journal Article,

Immunotoxicity of medical devices
Rodgers, K; Klykken, P; Jacobs, J; Frondoza, C; Tomazic, V; Zelikoff, J
1997 MAR ;36(1):1-14, Fundamental & applied toxicology
— id: 53210, year: 1997, vol: 36, page: 1, stat: Journal Article,

Eco Toxicology : responses, biomarkers and risk asssessment
Zelikoff, Judith T; Lynch JM; Shepers, James
Paris, France : Organisation of Economic Co-Operation and Development, 1997,
— id: 1224, year: 1997, vol: , page: , stat: ,

Modulators of immune responses: the evolutionary trail
Bayne CJ; Zelikoff JT
1996 Feb;17(2):55-57, Immunology today
— id: 66156, year: 1996, vol: 17, page: 55, stat: Journal Article,

Vanadium affects macrophage interferon-gamma-binding and -inducible responses
Cohen MD; McManus TP; Yang Z; Qu Q; Schlesinger RB; Zelikoff JT
1996 May;138(1):110-120, Toxicology & applied pharmacology
— id: 6988, year: 1996, vol: 138, page: 110, stat: Journal Article,

Pulmonary immunotoxicity of inhaled ammonium metavanadate in Fisher 344 rats
Cohen MD; Yang Z; Zelikoff JT; Schlesinger RB
1996 Oct;33(2):254-263, Fundamental & applied toxicology
— id: 12523, year: 1996, vol: 33, page: 254, stat: Journal Article,

Effects of ozone upon macrophage-interferon interactions
Cohen MD; Zelikoff JT; Qu Q; Schlesinger RB
1996 Dec 18;114(3):243-252, Toxicology
— id: 10366, year: 1996, vol: 114, page: 243, stat: Journal Article,

Health risks associated with prenatal metal exposure
Zelikoff JT; Bertin JE; Burbacher TM; Hunter ES; Miller RK; Silbergeld EK; Tabacova S; Rogers JM
1995 May;25(2):161-170, Fundamental & applied toxicology
— id: 6879, year: 1995, vol: 25, page: 161, stat: Journal Article,

Immunotoxicity of low level cadmium exposure in fish: an alternative animal model for immunotoxicological studies
Zelikoff JT; Bowser D; Squibb KS; Frenkel K
1995 Jul;45(3):235-248, Journal of toxicology & environmental health
— id: 6880, year: 1995, vol: 45, page: 235, stat: Journal Article,

Effects of in vitro nickel exposure on the macrophage-mediated immune functions of rainbow trout (Oncorhynchus mykiss)
Bowser DH; Frenkel K; Zelikoff JT
1994 Mar;52(3):367-373, Bulletin of environmental contamination & toxicology
— id: 7877, year: 1994, vol: 52, page: 367, stat: Journal Article,

Immunotoxicity of particulate lead: in vitro exposure alters pulmonary macrophage tumor necrosis factor production and activity
Cohen MD; Yang Z; Zelikoff JT
1994 Aug;42(4):377-392, Journal of toxicology & environmental health
— id: 8386, year: 1994, vol: 42, page: 377, stat: Journal Article,

PULMONARY EFFECTS OF REPEATED EPISODIC EXPOSURES TO NITRIC-ACID VAPOR ALONE AND IN COMBINATION WITH OZONE
SCHLESINGER, RB; ELFAWAL, HAN; ZELIKOFF, JT; GORCZYNSKI, JE; MCGOVERN, T; NADZIEJKO, CE; CHEN, LC
1994 JAN-FEB ;6(1):21-41, Inhalation toxicology
— id: 52566, year: 1994, vol: 6, page: 21, stat: Journal Article,

Immunotoxicity of sulfuric acid aerosol: effects on pulmonary macrophage effector and functional activities critical for maintaining host resistance against infectious diseases
Zelikoff JT; Sisco MP; Yang Z; Cohen MD; Schlesinger RB
1994 Sep 6;92(1-3):269-286, Toxicology
— id: 6788, year: 1994, vol: 92, page: 269, stat: Journal Article,

Immunomodulation by metals
Zelikoff JT; Smialowicz R; Bigazzi PE; Goyer RA; Lawrence DA; Maibach HI; Gardner D
1994 Jan;22(1):1-7, Fundamental & applied toxicology
— id: 6562, year: 1994, vol: 22, page: 1, stat: Journal Article,

Immunotoxicity of in vitro vanadium exposures: effects on interleukin-1, tumor necrosis factor-alpha, and prostaglandin E2 production by WEHI-3 macrophages
Cohen MD; Parsons E; Schlesinger RB; Zelikoff JT
1993 Apr;15(3):437-446, International journal of immunopharmacology
— id: 8422, year: 1993, vol: 15, page: 437, stat: Journal Article,

Biological markers of macrophage activation: applications for fish phagocytes
Enane NA; Frenkel K; O'Connor JM; Squibb KS; Zelikoff JT
1993 Sep;80(1):68-72, Immunology
— id: 6365, year: 1993, vol: 80, page: 68, stat: Journal Article,

EFFECTS OF INHALED NITRIC-ACID VAPOR ON PULMONARY IMMUNOCOMPETENCE - ALTERATIONS IN MACROPHAGE-MEDIATED IMMUNITY
SCHLESINGER, RB; ZELIKOFF, JT
1993 APR ;147(4):A384-A384, American review of respiratory disease
— id: 54157, year: 1993, vol: 147, page: A384, stat: Journal Article,

Inhalation of particulate lead oxide disrupts pulmonary macrophage-mediated functions important for host defense and tumor surveillance in the lung
Zelikoff JT; Parsons E; Schlesinger RB
1993 Aug;62(2):207-222, Environmental research
— id: 13094, year: 1993, vol: 62, page: 207, stat: Journal Article,

CONTRIBUTION OF SULFURIC-ACID TO RESPIRATORY-INFECTIONS
ZELIKOFF, JT; COHEN, MD; SISCO, MP; SCHLESINGER, RB
1993 APR ;147(4):A384-A384, American review of respiratory disease
— id: 54156, year: 1993, vol: 147, page: A384, stat: Journal Article,

Assessment of toxicologic interactions resulting from acute inhalation exposure to sulfuric acid and ozone mixtures
Schlesinger RB; Zelikoff JT; Chen LC; Kinney PL
1992 Aug;115(2):183-190, Toxicology & applied pharmacology
— id: 13514, year: 1992, vol: 115, page: 183, stat: Journal Article,

Modulation of pulmonary immune defense mechanisms by sulfuric acid: effects on macrophage-derived tumor necrosis factor and superoxide
Zelikoff JT; Schlesinger RB
1992 Dec 4;76(3):271-281, Toxicology
— id: 13341, year: 1992, vol: 76, page: 271, stat: Journal Article,

DNA damage by mercury compounds : an overview
Costa M; Christie NT; Cantoni O; Zelikoff JT; Wang XW; Rossman TG
Advances in mercury toxicology New York : Plenum Press, 1991,
— id: 4397, year: 1991, vol: , page: ?, stat: Chapter,

Development of fish peritoneal macrophages as a model for higher vertebrates in immunotoxicological studies. I. Characterization of trout macrophage morphological, functional, and biochemical properties
Zelikoff JT; Enane NA; Bowser D; Squibb KS; Frenkel K
1991 Apr;16(3):576-589, Fundamental & applied toxicology
— id: 14093, year: 1991, vol: 16, page: 576, stat: Journal Article,

Immunomodulating effects of ozone on macrophage functions important for tumor surveillance and host defense
Zelikoff JT; Kraemer GL; Vogel MC; Schlesinger RB
1991 Dec;34(4):449-467, Journal of toxicology & environmental health
— id: 13836, year: 1991, vol: 34, page: 449, stat: Journal Article,

Comparative potency of inhaled acidic sulfates: speciation and the role of hydrogen ion
Schlesinger RB; Chen LC; Finkelstein I; Zelikoff JT
1990 Aug;52(2):210-224, Environmental research
— id: 39559, year: 1990, vol: 52, page: 210, stat: Journal Article,

Pulmonary arachidonic acid metabolism following acute exposures to ozone and nitrogen dioxide
Schlesinger RB; Driscoll KE; Gunnison AF; Zelikoff JT
1990 Dec;31(4):275-290, Journal of toxicology & environmental health
— id: 14263, year: 1990, vol: 31, page: 275, stat: Journal Article,

Modulation of pulmonary eicosanoid metabolism following exposure to sulfuric acid
Schlesinger RB; Gunnison AF; Zelikoff JT
1990 Jul;15(1):151-162, Fundamental & applied toxicology
— id: 17587, year: 1990, vol: 15, page: 151, stat: Journal Article,

Sulfadimethoxine pharmacokinetics and metabolism in the channel catfish (Ictalurus punctatus)
Squibb KS; Michel CM; Zelikoff JT; O'Connor JM
1988 ;30 Suppl 1:31-35, Veternary & human toxicology
— id: 11247, year: 1988, vol: 30 Suppl 1, page: 31, stat: Journal Article,

Genetic toxicology of lead compounds
Zelikoff JT; Li JH; Hartwig A; Wang XW; Costa M; Rossman TG
1988 Oct;9(10):1727-1732, Carcinogenesis
— id: 10946, year: 1988, vol: 9, page: 1727, stat: Journal Article,

GENETIC TOXICOLOGY OF METAL-COMPOUNDS - AN EXAMINATION OF APPROPRIATE CELLULAR-MODELS
ROSSMAN, TG; ZELIKOFF, JT; AGARWAL, S; KNEIP, TJ
1987 MAY ;14(4):251-262, Toxicological & environmental chemistry
— id: 41713, year: 1987, vol: 14, page: 251, stat: Journal Article,

Differential phosphorylation events associated with phorbol ester effects on acceleration versus inhibition of cell growth
Zelikoff JT; Garte SJ; Belman S
1987 Jan 1;47(1):329-330, Cancer research
— id: 66157, year: 1987, vol: 47, page: 329, stat: Journal Article,

CYTOTOXICITY AND MUTAGENICITY OF INSOLUBLE METAL-SALTS IN V79 CELLS
Zelikoff, JT; Hartwig, A; Li, JH; Rossman, TG
1987 Mar;3(1):93-93, Cell biology & toxicology
— id: 31171, year: 1987, vol: 3, page: 93, stat: Journal Article,

TOXIC EFFECTS OF ENVIRONMENTALLY SIGNIFICANT PARTICLES USING CHINESE-HAMSTER LUNG-CELLS
ATKINS, NM; ZELIKOFF, JT; DAISEY, JM
1986 MAR ;22(3):A44-A44, In vitro
— id: 41347, year: 1986, vol: 22, page: A44, stat: Journal Article,

Sarcoid and cytotoxic lung antibodies
Ende N; Grizzanti JN; Orsi EV; Lubansky KP; Amoruso RC; Reichman LB; Zelikoff JT
1986 Dec 22;39(25):2435-2440, Life sciences
— id: 66158, year: 1986, vol: 39, page: 2435, stat: Journal Article,

Stimulation of cell growth and proliferation in NIH-3T3 cells by onion and garlic oils
Zelikoff JT; Atkins NM Jr; Belman S
1986 Sep;2(3):369-378, Cell biology & toxicology
— id: 11436, year: 1986, vol: 2, page: 369, stat: Journal Article,

MUTAGENICITY OF SOLUBLE METAL-SALTS USING THE V79/HGPRT MUTATION ASSAY
ZELIKOFF, JT; ATKINS, N; ROSSMAN, TG
1986 FEB ;8(2):95-95, Environmental mutagenesis
— id: 41512, year: 1986, vol: 8, page: 95, stat: Journal Article,

COMPARISON OF THE CYTOTOXICITY OF SOLUBLE AND INSOLUBLE METAL-SALTS ON V79 CELLS
ZELIKOFF, JT; LI, JH; ROSSMAN, TG
1986 MAR ;22(3):A47-A47, In vitro
— id: 41348, year: 1986, vol: 22, page: A47, stat: Journal Article,

Antibodies to synovial-derived cells in patients undergoing artificial prosthesis implants
Ende N; Orsi EV; Buechel FF; Baturay NZ; Zelikoff JT
1985 ;3(1):78-83, Journal of orthopaedic research
— id: 66160, year: 1985, vol: 3, page: 78, stat: Journal Article,

Balbc/3T3 cell transformation response to extracts of organic air samples as seen by their survival in aggregate form
Zelikoff JT; Daisey JM; Traul KA; Kneip TJ
1985 Oct;144(2):107-116, Mutation research
— id: 66159, year: 1985, vol: 144, page: 107, stat: Journal Article,

A COMPARISON OF METAL TOXICITY IN A MICROTITRE ASSAY SYSTEM, USING ESCHERICHIA-COLI AND V79 CELLS
Zelikoff, JT; Agarwal, S; Rossman, TG
1985 ;7(1):7-8, Environmental mutagenesis
— id: 30881, year: 1985, vol: 7, page: 7, stat: Journal Article,

CYTO-TOXICITY OF FINE PARTICLES WITH AND WITHOUT ADSORBED POLYCYCLIC AROMATIC-HYDROCARBONS USING CHINESE-HAMSTER LUNG-CELLS (V79)
ZELIKOFF, JT; ATKINS, NM; ROSSMAN, TG; DAISEY, JM
1985 ;11(2-4):331-339, Environment international
— id: 41200, year: 1985, vol: 11, page: 331, stat: Journal Article,

EFFECT OF ONION AND GARLIC OIL ON 3T3 CELL-TRANSFORMATION
Zelikoff, JT; Belman, S
1985 ;21(3):A41-A41, In vitro cellular & developmental biology
— id: 30825, year: 1985, vol: 21, page: A41, stat: Journal Article,

STIMULATION OF CELL-GROWTH AND PROLIFERATION IN NIH-3T3 CELLS USING ONION AND GARLIC OIL
ZELIKOFF, JT; ATKINS, N; BELMAN, S
1984 ;20(3):276-276, In vitro
— id: 40965, year: 1984, vol: 20, page: 276, stat: Journal Article,

CELLULAR UPTAKE AND CYTO-TOXICITY OF FINE PARTICLES WITH ADSORBED BENZO(A)PYRENE USING CHINESEHAMSTER LUNG CELLS(V79)
ZELIKOFF, JT; ATKINS, N; ROSSMAN, T; DAISEY, JM
1984 ;6(3):435-435, Environmental mutagenesis
— id: 40939, year: 1984, vol: 6, page: 435, stat: Journal Article,

PHAGOCYTOSIS OF COAL FLY ASH (CFA) PARTICLES BY CHINESE-HAMSTER LUNG-CELLS (V79) USING LIGHT AND SCANNING ELECTRON-MICROSCOPY (SEM)
Zelikoff, JT; Orsi, EV; Daisey, JM
1984 ;52(1):A42-A42, Biology of the cell
— id: 31004, year: 1984, vol: 52, page: A42, stat: Journal Article,

BALB-3T3 CELL RESPONSE TO EXTRACTS OF ORGANIC AIR SAMPLES AS SEEN BY THEIR SURVIVAL IN AGGREGATE FORM
ZELIKOFF, JT; ATKINS, N; ORSI, EV; KNEIP, TJ
1983 ;19(3):266-267, In vitro
— id: 50961, year: 1983, vol: 19, page: 266, stat: Journal Article,