Dun-Sheng Yang, Ph.D.

Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain
Saito, M; Chakraborty, G; Shah, R; Mao, RF; Kumar, A; Yang, DS; Dobrenis, K; Saito, M
2012 May;121(4):649-661, Journal of neurochemistry
— id: 166032, year: 2012, vol: 121, page: 649, stat: Journal Article,

Autophagy failure in Alzheimer's disease-locating the primary defect
Nixon RA; Yang DS
2011 Jul;43(1):38-45, Neurobiology of disease
— id: 126480, year: 2011, vol: 43, page: 38, stat: Journal Article,

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
Yang, Dun-Sheng; Lee, Ju-Hyun; Vinod, K Yaragudri; Stavrides, Philip; Amin, Niranjana D; Pant, Harish C; Nixon, Ralph A
2011 Nov;32(11):2016-2029, Neurobiology of aging
— id: 138382, year: 2011, vol: 32, page: 2016, stat: Journal Article,

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel W; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jul 1;7(7):788-789, Autophagy
— id: 134440, year: 2011, vol: 7, page: 788, stat: Journal Article,

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jan;134(Pt 1):258-277, Brain
— id: 126481, year: 2011, vol: 134, page: 258, stat: Journal Article,

A let-7 microRNA-binding site polymorphism in 3'-untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy
Zhang, W; Winder, T; Ning, Y; Pohl, A; Yang, D; Kahn, M; Lurje, G; Labonte, M J; Wilson, P M; Gordon, M A; Hu-Lieskovan, S; Mauro, D J; Langer, C; Rowinsky, E K; Lenz, H-J
2011 Jan;22(1):104-109, Annals of oncology
— id: 144132, year: 2011, vol: 22, page: 104, stat: Journal Article,

In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model
Chen, Yuanxin; Dyakin, Victor V; Branch, Craig A; Ardekani, Babak; Yang, Dunsheng; Guilfoyle, David N; Peterson, Jesse; Peterhoff, Corrinne; Ginsberg, Stephen D; Cataldo, Anne M; Nixon, Ralph A
2009 Sep;30(9):1453-1465, Neurobiology of aging
— id: 86660, year: 2009, vol: 30, page: 1453, stat: Journal Article,

Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases
Yang, Dun-Sheng; Lee, Ju-Hyun; Nixon, Ralph A
2009 ;453:111-144, Methods in enzymology
— id: 96862, year: 2009, vol: 453, page: 111, stat: Journal Article,

Neurodegenerative lysosomal disorders- a continuum from development to late age
Nixon, Ralph A; Yang, Dun-Sheng; Lee, Ju-Hyun
2008 Sep-Oct;4(5):590-599, Autophagy
— id: 79133, year: 2008, vol: 4, page: 590, stat: Journal Article,

Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression
Rao, Mala V; Mohan, Panaiyur S; Peterhoff, Corrinne M; Yang, Dun-Sheng; Schmidt, Stephen D; Stavrides, Philip H; Campbell, Jabbar; Chen, Yuanxin; Jiang, Ying; Paskevich, Peter A; Cataldo, Anne M; Haroutunian, Vahram; Nixon, Ralph A
2008 Nov 19;28(47):12241-12254, Journal of neuroscience
— id: 94362, year: 2008, vol: 28, page: 12241, stat: Journal Article,

Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
Yang, Dun-Sheng; Kumar, Asok; Stavrides, Philip; Peterson, Jesse; Peterhoff, Corrine M; Pawlik, Monika; Levy, Efrat; Cataldo, Anne M; Nixon, Ralph A
2008 Sep;173(3):665-681, American journal of pathology
— id: 86556, year: 2008, vol: 173, page: 665, stat: Journal Article,

Autophagy in Alzheimer's disease pathogenesis
Nixon, RA; Yu, WH; Cuervo, AM; Cataldo, AM; Mathews, PM; Yang, DS; Zheng, P; Peterhoff, CM; Kumar, A; Jiang, Y; Peterson, J; Schmidt, SD; Mohan, P; Duff, K; Hassinger, L; Wegiel, J; Lamb, B
2004 JUL ;25(10):S70-S71, Neurobiology of aging
— id: 47716, year: 2004, vol: 25, page: S70, stat: Journal Article,

Neurodegeneration in a mouse model of Alzheimer's disease (AD): Roles of apoptosis and autophagy
Yang, DS; Kumar, A; Peterson, J; Peterhoff, CM; Duff, K; Nixon, RA; Jeyathevan, R; Martins, RN; Cataldo, AM
2004 JUL ;25(10):S437-S437, Neurobiology of aging
— id: 47738, year: 2004, vol: 25, page: S437, stat: Journal Article,

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
Yang, Dun-Sheng; Tandon, Anurag; Chen, Fusheng; Yu, Gang; Yu, Haung; Arawaka, Shigeki; Hasegawa, Hiroshi; Duthie, Monika; Schmidt, Stephen D; Ramabhadran, Triprayer V; Nixon, Ralph A; Mathews, Paul M; Gandy, Samuel E; Mount, Howard T J; St George-Hyslop, Peter; Fraser, Paul E
2002 Aug 2;277(31):28135-28142, Journal of biological chemistry
— id: 62376, year: 2002, vol: 277, page: 28135, stat: Journal Article,

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
Chishti MA; Yang DS; Janus C; Phinney AL; Horne P; Pearson J; Strome R; Zuker N; Loukides J; French J; Turner S; Lozza G; Grilli M; Kunicki S; Morissette C; Paquette J; Gervais F; Bergeron C; Fraser PE; Carlson GA; George-Hyslop PS; Westaway D
2001 Jun 15;276(24):21562-21570, Journal of biological chemistry
— id: 24744, year: 2001, vol: 276, page: 21562, stat: Journal Article,

Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention
Yang DS; Serpell LC; Yip CM; McLaurin J; Chrishti MA; Horne P; Boudreau L; Kisilevsky R; Westaway D; Fraser PE
2001 Jul;8 Suppl 1(1):10-19, Amyloid
— id: 24749, year: 2001, vol: 8 Suppl 1, page: 10, stat: Journal Article,

Carboxyl-Terminal Fragments of Alzheimer {beta}-Amyloid Precursor Protein Accumulate in Restricted and Unpredicted Intracellular Compartments in Presenilin 1 Deficient Cells
Chen F; Yang DS; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang DM; Kawarai T; Levesque G; Mills J; Levesque L; Song YQ; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser PE
2000 Nov;275(47):36794-36802, Journal of biological chemistry
— id: 9785, year: 2000, vol: 275, page: 36794, stat: Journal Article,

Presenilin structure, function and role in Alzheimer disease
Fraser PE; Yang DS; Yu G; Levesque L; Nishimura M; Arawaka S; Serpell LC; Rogaeva E; St George-Hyslop P
2000 Jul 26;1502(1):1-15, Biochimica & biophysica acta
— id: 24747, year: 2000, vol: 1502, page: 1, stat: Journal Article,

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in vitro model of preamyloid
Huang TH; Yang DS; Fraser PE; Chakrabartty A
2000 Nov 17;275(46):36436-36440, Journal of biological chemistry
— id: 24767, year: 2000, vol: 275, page: 36436, stat: Journal Article,

Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide
Huang TH; Yang DS; Plaskos NP; Go S; Yip CM; Fraser PE; Chakrabartty A
2000 Mar 17;297(1):73-87, Journal of molecular biology
— id: 24748, year: 2000, vol: 297, page: 73, stat: Journal Article,

Review: modulating factors in amyloid-beta fibril formation
McLaurin J; Yang D; Yip CM; Fraser PE
2000 Jun;130(2-3):259-270, Journal of structural biology
— id: 24769, year: 2000, vol: 130, page: 259, stat: Journal Article,

Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation
Qin K; Yang DS; Yang Y; Chishti MA; Meng LJ; Kretzschmar HA; Yip CM; Fraser PE; Westaway D
2000 Jun 23;275(25):19121-19131, Journal of biological chemistry
— id: 24768, year: 2000, vol: 275, page: 19121, stat: Journal Article,

Examining the zinc binding site of the amyloid-beta peptide
Yang DS; McLaurin J; Qin K; Westaway D; Fraser PE
2000 Nov;267(22):6692-6698, European journal of biochemistry
— id: 24745, year: 2000, vol: 267, page: 6692, stat: Journal Article,

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
Yu G; Nishimura M; Arawaka S; Levitan D; Zhang L; Tandon A; Song YQ; Rogaeva E; Chen F; Kawarai T; Supala A; Levesque L; Yu H; Yang DS; Holmes E; Milman P; Liang Y; Zhang DM; Xu DH; Sato C; Rogaev E; Smith M; Janus C; Zhang Y; Aebersold R; Farrer LS; Sorbi S; Bruni A; Fraser P; St George-Hyslop P
2000 Sep 7;407(6800):48-54, Nature
— id: 24746, year: 2000, vol: 407, page: 48, stat: Journal Article,

New clothes for amyloid enhancing factor (AEF): silk as AEF
Kisilevsky R; Lemieux L; Boudreau L; Yang DS; Fraser P
1999 Jun;6(2):98-106, Amyloid
— id: 25194, year: 1999, vol: 6, page: 98, stat: Journal Article,

Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner
Yang DS; Small DH; Seydel U; Smith JD; Hallmayer J; Gandy SE; Martins RN
1999 ;90(4):1217-1226, Neuroscience
— id: 24711, year: 1999, vol: 90, page: 1217, stat: Journal Article,

Manipulating the amyloid-beta aggregation pathway with chemical chaperones
Yang DS; Yip CM; Huang TH; Chakrabartty A; Fraser PE
1999 Nov 12;274(46):32970-32974, Journal of biological chemistry
— id: 24751, year: 1999, vol: 274, page: 32970, stat: Journal Article,

No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia
Taddei K; Yang D; Fisher C; Clarnette R; Hallmayer J; Barnetson R; Maller R; Brooks WS; Whyte S; Nicholson GA; Masters CL; Broe GA; Gandy SE; Martins RN
1998 May 1;246(3):178-180, Neuroscience letters
— id: 24770, year: 1998, vol: 246, page: 178, stat: Journal Article,

Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma
Yang DS; Smith JD; Zhou Z; Gandy SE; Martins RN
1997 Feb;68(2):721-725, Journal of neurochemistry
— id: 24771, year: 1997, vol: 68, page: 721, stat: Journal Article,