Home
Adam Wolkin

You are about to go to a non-NYULMC website.

Biosketch / Results /

Adam Wolkin, M.D.

Associate Professor;
Department of Psychiatry

Contact Info

Address
423 East 23 Street
VA New York Harbor Healthcare System Floor 17 Room 17017
Veterans Administration
New York, NY 10010

Phone: 212-686-7500 ext.7521
Fax: 212-951-3356
Email: Adam.Wolkin@nyumc.org

« Back to Results

Research Summary

Our research primarily focuses on neuroimaging in schizophrenia conducted in collaboration with the Nathan Kline Institute, Brookhaven National Laboratory, and the NYU School of Medicine's Department of Radiology. In previous functional studies of schizophrenia using positron emission tomography (PET), we concentrated on cerebral metabolic patterns of glucose utilization that distinguish schizophrnic patients from normal subjects, and in differentiating schizophrenic subtypes. For example, we and others found a reduction in frontal lobe metabolism in schizophrenia patients as compared to normal subjects and that this pattern of metabolic hypofrontally correlated with the severity of "negative" symptoms. We also utilized PET in clinical pharmacologic studies, in which, for example, we studied the cerebral metabolic response to acute amphetamine challenge and subchronic haleoperidol treatment in schizophrenic patients, as well as characterized dopamine receptor occupancy related to neuroleptic treatment and clinical response.

Our structural studies in schizophrenia derive from a data base of high-resolution 3D TI- and T2- weighted images which we acquired throughtout the entire brain in over 100 schizophrenic patients and normal control subjects. These studies were conducted at the New York Department of Veterans Affairs Medical Center magnetic resonance imaging (MRI) facility. Data analysis included volumetric and alternative analysis, including shape analysis and image averaging (co-registration) techniques. Results suggest two separate pathological processes underlying the pathophysiology of negative symptoms of schizophrenia wherein frontal lobe dysfunction and associated cognitive deficits may derive, in part, from a "dysconnection" of frontal pathways.

In ongoing and future work, we plan to further pursue these questions and hypotheses with functional MRI studies of cognitive processes in negative and non-negative syndrome schizophrenic patients.

Research Interests

Cerebral Structural and Functional Abnormalities in Schizophrenia

Research Keywords

brain mapping, frontal lobe, magnetic resonance imaging (MRI), negative symptoms, positron emission tomography (PET), schizophrenia

« Back to Results

All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search#about

FDG-PET and MRI imaging of the effects of sertindole and haloperidol in the prefrontal lobe in schizophrenia
Buchsbaum, Monte S; Haznedar, Mehmet; Newmark, Randall E; Chu, King-Wai; Dusi, Nicola; Entis, Jonathan J; Goldstein, Kim E; Goodman, Chelain R; Gupta, Adarsh; Hazlett, Erin; Iannuzzi, James; Torosjan, Yuliya; Zhang, Jane; Wolkin, Adam
2009 Oct;114(1-3):161-171, Schizophrenia research
— id: 138039, year: 2009, vol: 114, page: 161, stat: Journal Article,

Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study
Wolkin, Adam; Choi, Steven J; Szilagyi, Sandor; Sanfilipo, Michael; Rotrosen, John P; Lim, Kelvin O
2003 Mar;160(3):572-574, American journal of psychiatry
— id: 94337, year: 2003, vol: 160, page: 572, stat: Journal Article,

A neuropathology of psychosis?
Wolkin, Adam; Rusinek, Henry
2003 Jan 25;361(9354):270-271, Lancet
— id: 73260, year: 2003, vol: 361, page: 270, stat: Journal Article,

Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study
Lim, Kelvin O; Choi, Steven J; Pomara, Nunzio; Wolkin, Adam; Rotrosen, John P
2002 Jun 1;51(11):890-895, Biological psychiatry
— id: 32117, year: 2002, vol: 51, page: 890, stat: Journal Article,

Cognitive performance in schizophrenia: relationship to regional brain volumes and psychiatric symptoms
Sanfilipo, Michael; Lafargue, Todd; Rusinek, Henry; Arena, Luigi; Loneragan, Celia; Lautin, Andrew; Rotrosen, John; Wolkin, Adam
2002 Nov 30;116(1-2):1-23, Psychiatry research
— id: 73261, year: 2002, vol: 116, page: 1, stat: Journal Article,

Cardiovascular Effects of 0.5 Milligrams per Kilogram Oral d-Amphetamine and Possible Attenuation by Haloperidol
Angrist B; Sanfilipo M; Wolkin A
2001 May-Jun;24(3):139-144, Clinical neuropharmacology
— id: 20630, year: 2001, vol: 24, page: 139, stat: Journal Article,

Fine volumetric analysis of the cerebral ventricular system in schizophrenia: further evidence for multifocal mild to moderate enlargement
Sanfilipo M; Lafargue T; Arena L; Rusinek H; Kushner K; Lautin A; Loneragan C; Vaid G; Rotrosen J; Wolkin A
2000 ;26(1):201-216, Schizophrenia bulletin
— id: 23575, year: 2000, vol: 26, page: 201, stat: Journal Article,

Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms
Sanfilipo M; Lafargue T; Rusinek H; Arena L; Loneragan C; Lautin A; Feiner D; Rotrosen J; Wolkin A
2000 May;57(5):471-480, Archives of general psychiatry
— id: 23576, year: 2000, vol: 57, page: 471, stat: Journal Article,

Effect of a haloperidol challenge on regional brain metabolism in neuroleptic-responsive and nonresponsive schizophrenic patients
Bartlett EJ; Brodie JD; Simkowitz P; Schlosser R; Dewey SL; Lindenmayer JP; Rusinek H; Wolkin A; Cancro R; Schiffer W
1998 Mar;155(3):337-343, American journal of psychiatry
— id: 7497, year: 1998, vol: 155, page: 337, stat: Journal Article,

Fronto-striatal circuits assessed by positron emission tomography in patients treated with atypical neuroleptics, typical neuroleptics, and fenfluramine
Buchsbaum, MS; Wolkin, A; Hazlett, E; Fallon, J; Guich, S; Gupta, A; Siever, L; McCarthy, BG
1998 APR 15 ;43(4):73-18, Biological psychiatry
— id: 98349, year: 1998, vol: 43, page: 73, stat: Journal Article,

Inter-subject coregistration of brain images : a phantom study
Rusinek H; Tsui W-H; Sanfilipo M; Wolkin A
1998 ;3338:61-69, Medical imaging. Image processing (SPIE)
— id: 73287, year: 1998, vol: 3338, page: 61, stat: Journal Article,

Structural magnetic resonance image averaging in schizophrenia
Wolkin A; Rusinek H; Vaid G; Arena L; Lafargue T; Sanfilipo M; Loneragan C; Lautin A; Rotrosen J
1998 Aug;155(8):1064-1073, American journal of psychiatry
— id: 23577, year: 1998, vol: 155, page: 1064, stat: Journal Article,

Time-dependent effects of a haloperidol challenge on energy metabolism in the normal human brain
Bartlett EJ; Brodie JD; Simkowitz P; Dewey SL; Rusinek H; Volkow ND; Wolf AP; Smith G; Wolkin A; Cancro R
1996 Mar 29;60(2-3):91-99, Psychiatry research
— id: 12632, year: 1996, vol: 60, page: 91, stat: Journal Article,

Amphetamine and negative symptoms of schizophrenia
Sanfilipo M; Wolkin A; Angrist B; van Kammen DP; Duncan E; Wieland S; Cooper TB; Peselow ED; Rotrosen J
1996 Jan;123(2):211-214, Psychopharmacology
— id: 23583, year: 1996, vol: 123, page: 211, stat: Journal Article,

The study of neurotransmitter interactions using positron emission tomography and functional coupling
Schloesser R; Simkowitz P; Bartlett EJ; Wolkin A; Smith GS; Dewey SL; Brodie JD
1996 Oct;19(5):371-389, Clinical neuropharmacology
— id: 12529, year: 1996, vol: 19, page: 371, stat: Journal Article,

Blunted change in cerebral glucose utilization after haloperidol treatment in schizophrenic patients with prominent negative symptoms
Wolkin A; Sanfilipo M; Duncan E; Angrist B; Wolf AP; Cooper TB; Brodie JD; Laska E; Rotrosen JP
1996 Mar;153(3):346-354, American journal of psychiatry
— id: 7060, year: 1996, vol: 153, page: 346, stat: Journal Article,

Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects
Bartlett EJ; Brodie JD; Simkowitz P; Dewey SL; Rusinek H; Wolf AP; Fowler JS; Volkow ND; Smith G; Wolkin A
1994 May;151(5):681-686, American journal of psychiatry
— id: 6319, year: 1994, vol: 151, page: 681, stat: Journal Article,

Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study
Guenther, W; Brodie, J D; Bartlett, E J; Dewey, S L; Henn, F A; Volkow, N D; Alper, K; Wolkin, A; Cancro, R; Wolf, A P
1994 ;244(3):115-125, European archives of psychiatry & clinical neuroscience
— id: 76242, year: 1994, vol: 244, page: 115, stat: Journal Article,

Persistent psychosis after reduction in pre- and post-synaptic dopaminergic function
Wolkin A; Duncan E; Sanfilipo M; Wieland S; Cooper TB; Rotrosen J
1994 ;95(1):49-61, Journal of neural transmission
— id: 23584, year: 1994, vol: 95, page: 49, stat: Journal Article,

Acute d-amphetamine challenge in schizophrenia: effects on cerebral glucose utilization and clinical symptomatology
Wolkin A; Sanfilipo M; Angrist B; Duncan E; Wieland S; Wolf AP; Brodie JD; Cooper TB; Laska E; Rotrosen JP
1994 Sep 1;36(5):317-325, Biological psychiatry
— id: 8462, year: 1994, vol: 36, page: 317, stat: Journal Article,

Plasma homovanillic acid in neuroleptic responsive and nonresponsive schizophrenics
Duncan E; Wolkin A; Angrist B; Sanfilipo M; Wieland S; Cooper TB; Rotrosen J
1993 Oct 15;34(8):523-528, Biological psychiatry
— id: 57549, year: 1993, vol: 34, page: 523, stat: Journal Article,

Elevated PLA2 activity in schizophrenics and other psychiatric patients
Noponen M; Sanfilipo M; Samanich K; Ryer H; Ko G; Angrist B; Wolkin A; Duncan E; Rotrosen J
1993 Nov 1;34(9):641-649, Biological psychiatry
— id: 23585, year: 1993, vol: 34, page: 641, stat: Journal Article,

ACUTE CEREBRAL METABOLIC RESPONSE TO HALOPERIDOL - BIOCHEMICAL AND BEHAVIORAL CORRELATIONS
SIMKOWITZ, P; BARTLETT, EJ; BRODIE, JD; CONVIT, A; WOLKIN, A; FRIEDHOFF, AJ; DEWEY, SL; WOLF, AP
1993 MAR 15 ;33(6A):A68-A68, Biological psychiatry
— id: 54173, year: 1993, vol: 33, page: A68, stat: Journal Article,

Negative symptoms and hypofrontality in chronic schizophrenia
Wolkin A; Sanfilipo M; Wolf AP; Angrist B; Brodie JD; Rotrosen J
1992 Dec;49(12):959-965, Archives of general psychiatry
— id: 57503, year: 1992, vol: 49, page: 959, stat: Journal Article,

Amphetamine response and duration of illness in schizophrenia
Angrist, B; Sanfilipo, M; Wolkin, A
1991 Oct;5(3):200-201, Biological psychiatry
— id: 106690, year: 1991, vol: 5, page: 200, stat: Journal Article,

Stability of resting deoxyglucose metabolic values in PET studies of schizophrenia
Bartlett EJ; Barouche F; Brodie JD; Wolkin A; Angrist B; Rotrosen J; Wolf AP
1991 May;40(1):11-20, Psychiatry research
— id: 14038, year: 1991, vol: 40, page: 11, stat: Journal Article,

Importance of pharmacologic control in PET studies: effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia
Bartlett EJ; Wolkin A; Brodie JD; Laska EM; Wolf AP; Sanfilipo M
1991 Oct;40(2):115-124, Psychiatry research
— id: 13887, year: 1991, vol: 40, page: 115, stat: Journal Article,

Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia
Wolkin A; Barouche F; Wolf AP; Rotrosen J; Fowler JS; Shiue CY; Cooper TB; Brodie JD
1989 Jul;146(7):905-908, American journal of psychiatry
— id: 8395, year: 1989, vol: 146, page: 905, stat: Journal Article,

Dopamine receptor occupancy and plasma haloperidol levels
Wolkin A; Brodie JD; Barouche F; Rotrosen J; Wolf AP; Smith M; Fowler J; Cooper TB
1989 May;46(5):482-484, Archives of general psychiatry
— id: 23596, year: 1989, vol: 46, page: 482, stat: Journal Article,

Regional glucose metabolism in chronic schizophrenia
Brodie JD; Wolkin A; Wolf AP; Volkow N; Russell JA; Van Gelder P; Jaeger J; Fowler J; Rotrosen J; Cancro R
1988 ;3(1):54-54, American journal of physiologic imaging
— id: 11210, year: 1988, vol: 3, page: 54, stat: Journal Article,

Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients
Smith M; Wolf AP; Brodie JD; Arnett CD; Barouche F; Shiue CY; Fowler JS; Russell JA; MacGregor RR; Wolkin A; et al.
1988 Apr 1;23(7):653-663, Biological psychiatry
— id: 62153, year: 1988, vol: 23, page: 653, stat: Journal Article,

Low frontal glucose utilization in chronic schizophrenia: a replication study
Wolkin A; Angrist B; Wolf A; Brodie JD; Wolkin B; Jaeger J; Cancro R; Rotrosen J
1988 Feb;145(2):251-253, American journal of psychiatry
— id: 11197, year: 1988, vol: 145, page: 251, stat: Journal Article,

PET STUDIES IN SCHIZOPHRENIA
Brodie, JD; Wolf, AP; Bartlett, E; Wolkin, A; Vangelder, P; Volkow, N
1987 Apr;32(1-2):788-788, International journal of neuroscience
— id: 31395, year: 1987, vol: 32, page: 788, stat: Journal Article,

PET STUDIES IN SCHIZOPHRENIA
Brodie, JD; Wolf, AP; Wolkin, A; Arnett, CD; Angrist, B; Fowler, J; Smith, M; Russell, J; Logan, J; Christman, D; Rotrosen, J; Volkow, N
1987 Apr;32(1-2):445-445, International journal of neuroscience
— id: 31391, year: 1987, vol: 32, page: 445, stat: Journal Article,

Effects of amphetamine on local cerebral metabolism in normal and schizophrenic subjects as determined by positron emission tomography
Wolkin A; Angrist B; Wolf A; Brodie J; Wolkin B; Jaeger J; Cancro R; Rotrosen J
1987 ;92(2):241-246, Psychopharmacology
— id: 23614, year: 1987, vol: 92, page: 241, stat: Journal Article,

Essential fatty acid supplementation during early alcohol abstinence
Wolkin A; Segarnick D; Sierkierski J; Manku M; Horrobin D; Rotrosen J
1987 Feb;11(1):87-92, Alcoholism: clinical & experimental research
— id: 23610, year: 1987, vol: 11, page: 87, stat: Journal Article,

MADNESS AND CLARITY
WOLKIN, A; CANCRO, R
1987 JUN ;10(2):225-226, Behavioral & brain sciences
— id: 41669, year: 1987, vol: 10, page: 225, stat: Journal Article,

EFFECTS OF AMPHETAMINE ON LOCAL CEREBRAL METABOLISM IN NORMAL AND SCHIZOPHRENIC SUBJECTS AS DETERMINED BY POSITRON EMISSION TOMOGRAPHY USING [C-11-1] 2-DEOXY-D-GLUCOSE (C-11-2DG)
BRODIE, JD; WOLKIN, A; ANGRIST, B; WOLF, AP; JORDAN, B; JAEGER, J; CANCRO, R; ROTROSEN, J
1986 JUN ;27(6):901-901, Journal of nuclear medicine
— id: 41433, year: 1986, vol: 27, page: 901, stat: Journal Article,

Niacin-induced flush as a measure of prostaglandin activity in alcoholics and schizophrenics
Fiedler P; Wolkin A; Rotrosen J
1986 Nov;21(13):1347-1350, Biological psychiatry
— id: 23617, year: 1986, vol: 21, page: 1347, stat: Journal Article,

The dexamethasone suppression test and response to placebo
Peselow ED; Lautin A; Wolkin A; Rohrs C; Novatt A; Siekierski J; Rotrosen J
1986 Oct;6(5):286-291, Journal of clinical psychopharmacology
— id: 23618, year: 1986, vol: 6, page: 286, stat: Journal Article,

SERIAL [F-18] N-METHYLSPIROPERIDOL (F-18 NMS) PET STUDIES MEASURE CHANGES IN ANTIPSYCHOTIC DRUG D2 RECEPTOR OCCUPANCY IN SCHIZOPHRENICS
SMITH, M; WOLF, AP; SHIUE, CY; FOWLER, JS; RUSSELL, JAG; MACGREGOR, R; ARNETT, C; LOGAN, J; WOLKIN, A; ROTROSEN, J; BRODIE, JD
1986 JUN ;27(6):880-880, Journal of nuclear medicine
— id: 41431, year: 1986, vol: 27, page: 880, stat: Journal Article,

Essential fatty acid supplementation in tardive dyskinesia
Wolkin A; Jordan B; Peselow E; Rubinstein M; Rotrosen J
1986 Jul;143(7):912-914, American journal of psychiatry
— id: 23619, year: 1986, vol: 143, page: 912, stat: Journal Article,

Amphetamine response and relapse risk after depot neuroleptic discontinuation
Angrist B; Peselow E; Rubinstein M; Wolkin A; Rotrosen J
1985 ;85(3):277-283, Psychopharmacology
— id: 23630, year: 1985, vol: 85, page: 277, stat: Journal Article,

Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography
Wolkin A; Jaeger J; Brodie JD; Wolf AP; Fowler J; Rotrosen J; Gomez-Mont F; Cancro R
1985 May;142(5):564-571, American journal of psychiatry
— id: 23625, year: 1985, vol: 142, page: 564, stat: Journal Article,

REGIONAL GLUCOSE-METABOLISM IN CHRONIC-SCHIZOPHRENIA
Brodie, JD; Wolkin, A; Wolfe, AP; Jaeger, J; Fowler, J; Rotrosen, J; Cancro, R
1984 ;2(3):226-226, International journal of psychophysiology
— id: 30978, year: 1984, vol: 2, page: 226, stat: Journal Article,

TRH test abnormalities in psychiatric disorders
Wolkin A; Peselow ED; Smith M; Lautin A; Kahn I; Rotrosen J
1984 Jun;6(3-4):273-281, Journal of affective disorders
— id: 23634, year: 1984, vol: 6, page: 273, stat: Journal Article,

Plasma cortisol values after dexamethasone in depressed inpatients
Peselow ED; Serby M; Wolkin A; Deutsch SI; Fricchione G; Rotrosen JP
1983 Feb;3(1):45-46, Journal of clinical psychopharmacology
— id: 23572, year: 1983, vol: 3, page: 45, stat: Journal Article,

Red cell phospholipids in schizophrenia
Lautin A; Cordasco DM; Segarnick DJ; Wood L; Mason MF; Wolkin A; Rotrosen J
1982 Dec 27;31(26):3051-3056, Life sciences
— id: 23640, year: 1982, vol: 31, page: 3051, stat: Journal Article,