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Daniel TurnbullProfessor, Department of Radiology;Professor, Department of Pathology
540-562 First Avenue
New York, NY 10016
Education— University of Toronto, Graduate Education
Research SummaryThe availability of genetic analysis and transgenic techniques in the mouse have led to its widespread acceptance as the preferred animal model for studying mammalian embryonic development and many human diseases. Ultrasound and magnetic resonance (MR) micro-imaging methods are being developed in the Turnbull laboratory for noninvasive analysis of development and disease in genetically-engineered mouse models.
A 40-50 MHz ultrasound biomicroscope (UBM) has been developed for imaging and measuring hemodynamic parameters in utero through all the critical stages of early brain and heart development, enabling dynamic analysis of mutant and transgenic mice with brain and heart defects. For direct manipulation of mouse embryos, a system for in utero UBM-guided injection of cells and viruses was developed, which is currently being used to study cell lineage and fate in the mouse embryonic brain, and to induce ectopic gene expression using retroviruses.
A number of in vivo MR micro-imaging imaging methods have been developed on a 7-Tesla MRI to study brain tumor development and progressive neuro-degeneration in genetically-engineered mouse models of Multiple Sclerosis and Alzheimer?s disease. Contrast-enhancement with manganese is being investigated for imaging early postnatal brain development in the mouse, and for mapping neural activity in the adult and developing brain. Finally, targeted contrast-labeling approaches are being developed and tested to detect and monitor disease processes and for cellular imaging in the developing and diseased mouse brain.
Research InterestsIn-Vivo Microimaging of Transgenic Mice
3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging
Deans, Abby E; Wadghiri, Youssef Zaim; Aristizabal, Orlando; Turnbull, Daniel H
2015-04-20; 1095-9572,Neuroimage - id: 1532932, year: 2015 JOURNAL ARTICLE
Engineering an effective Mn-binding MRI reporter protein by subcellular targeting
Bartelle, Benjamin B; Mana, Miyeko D; Suero-Abreu, Giselle A; Rodriguez, Joe J; Turnbull, Daniel H
2014-12-22; 0740-3194,Magnetic resonance in medicine - id: 1411432, year: 2014 JOURNAL ARTICLE
In vivo mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model
Suero-Abreu, Giselle A; Praveen Raju, G; Aristizabal, Orlando; Volkova, Eugenia; Wojcinski, Alexandre; Houston, Edward J; Pham, Diane; Szulc, Kamila U; Colon, Daniel; Joyner, Alexandra L; Turnbull, Daniel H
2014-12-22; 1476-5586,Neoplasia - id: 1410732, year: 2014 Journal Article
High-frequency ultrasound for in vivo, 3D imaging and analysis of mouse embryo brain development
Aristizabal, O; Turnbull, DH; Mamou, J; Ketterling, JA
2014-06-03; 1948-5719,Proceedings (IEEE International Ultrasonics Symposium) - id: 1022422, year: 2013
High-throughput, high-frequency 3-d ultrasound for in utero analysis of embryonic mouse brain development
Aristizabal, Orlando; Mamou, Jonathan; Ketterling, Jeffrey A; Turnbull, Daniel H
2013-11-25; 0301-5629,Ultrasound in medicine & biology - id: 641522, year: 2013 Journal Article