Eric E. Sigmund

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Eric E. Sigmund, Ph.D.

Assistant Professor;
Department of Radiology (CBI)

Contact Info

660 First Ave.
4th Floor Floor 4th floor Room 404
660 First Avenue
New York, NY 10016


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1996-2002 — Northwestern University, Graduate Education
2003-2004 — Northwestern University -- Radiology, PostDoctoral Training
2004-2006 — Schlumberger, PostDoctoral Training

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Research Summary

Diffusion-weighted imaging (DWI) is a remarkable magnetic resonance imaging (MRI) tool that provides sensitivity to tissue microstructure and water mobility on the micron scale and embeds this information as contrast in macroscopic images of the human body. In this approach, water molecules become reporters of their host tissue microenvironment, whether it be restricting or driving their local motion due to native or pathological processes. The applications of this technique are as varied as the behavior of water within biological tissue, and with the proper acquisition and analysis framework, can include diagnostic and prognostic biomarkers of tissue function across a range of disorders. My research group works at the translational interface between technical development and clinical application of DWI, both providing new imaging / analysis tools and applying them in clinical populations to determine their optimum benefit. In the area of breast cancer, conventional DWI is an established marker of aggressive cellularity through its restriction of apparent water diffusion. Our implementation of the intravoxel incoherent motion (IVIM) approach, however, provides sensitivity not only to cellularity but also separately to the often concomitant growth of neovasculature (angiogenesis) that supports tumors? hyperactive growth. We are also exploring the connection of these IVIM biomarkers to histological microstructural metrics, systemic anomalies like interstitial fluid pressure, and hormonal prognostic factors to maximize their potential in both diagnosis and prediction of treatment response. Skeletal muscle is another system where microstructure heavily impacts macroscopic function. We apply diffusion tensor imaging (DTI)?a technique sensitive to tissue directionality through anisotropic water restriction-- to skeletal muscle pathologies such as chronic exertional compartment syndrome, in order to improve detection as well as understand the biophysical mechanism of this debilitating disorder. However, since the kinematics of muscle motion are often key to diagnosis, we are simultaneously developing a new approach to muscle DTI. In this revolutionary development, a Multiple Echo Diffusion Tensor Acqusition Technique (MEDITATE), the required variation of the diffusion sensitization (both magnitude and direction) is compressed to very few scans through the use of multiple echoes. This acceleration may then allow DTI microstructural metrics to be captured dynamically, during muscle exertion.

Research Interests

Technical development:Diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM) imaging, diffusion tensor imaging (DTI), dynamical DTI, time-dependent diffusion, ultra-high field imaging. Oncological imaging: multi-parametric assessment of tumor microenvironment, predicting treatment response, interstitial fluid pressure. Muscle imaging: microscopic correlates of macroscopic insult, chronic exertional compartment syndrome.

Research Keywords

diffusion imaging, DWI, DTI, IVIM, DKI, interstitial fluid pressure, dynamical DTI

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All data from NYU Health Sciences Library Faculty Bibliography — -


A model-based reconstruction for undersampled radial spin-echo DTI with variational penalties on the diffusion tensor
Knoll, Florian; Raya, Jose G; Halloran, Rafael O; Baete, Steven; Sigmund, Eric; Bammer, Roland; Block, Tobias; Otazo, Ricardo; Sodickson, Daniel K
2015 Jan;:42-42, NMR in biomedicine
— id: 1436482, year: 2015, vol: , page: 42, stat: Journal Article,

Comparison of fitting methods and b-value sampling strategies for intravoxel incoherent motion in breast cancer
Cho, Gene Young; Moy, Linda; Zhang, Jeff L; Baete, Steven; Lattanzi, Riccardo; Moccaldi, Melanie; Babb, James S; Kim, Sungheon; Sodickson, Daniel K; Sigmund, Eric E
2014 Oct;:368-370, Magnetic resonance in medicine
— id: 1300192, year: 2014, vol: , page: 368, stat: Journal Article,

Subtype Differentiation of Renal Tumors Using Voxel-Based Histogram Analysis of Intravoxel Incoherent Motion Parameters
Gaing, Byron; Sigmund, Eric E; Huang, William C; Babb, James S; Parikh, Nainesh S; Stoffel, David; Chandarana, Hersh
2014 Nov;:?-? e32, Investigative radiology
— id: 1348892, year: 2014, vol: , page: ?, stat: Journal Article,

Combined intravoxel incoherent motion and diffusion tensor imaging of renal diffusion and flow anisotropy
Notohamiprodjo, Mike; Chandarana, Hersh; Mikheev, Artem; Rusinek, Henry; Grinstead, John; Feiweier, Thorsten; Raya, Jose G; Lee, Vivian S; Sigmund, Eric E
2014 Apr;:778-783, Magnetic resonance in medicine
— id: 900442, year: 2014, vol: , page: 778, stat: Journal Article,

Time-dependent diffusion in skeletal muscle with the random permeable barrier model (RPBM): application to normal controls and chronic exertional compartment syndrome patients
Sigmund, Eric E; Novikov, Dmitry S; Sui, Dabang; Ukpebor, Obehi; Baete, Steven; Babb, James S; Liu, Kecheng; Feiweier, Thorsten; Kwon, Jane; McGorty, Kellyanne; Bencardino, Jenny; Fieremans, Els
2014 May;27(5):519-528, NMR in biomedicine
— id: 875412, year: 2014, vol: 27, page: 519, stat: Journal Article,

New magnetic resonance imaging methods in nephrology
Zhang, Jeff L; Morrell, Glen; Rusinek, Henry; Sigmund, Eric E; Chandarana, Hersh; Lerman, Lilach O; Prasad, Pottumarthi V; Niles, David; Artz, Nathan; Fain, Sean; Vivier, Pierre-Hugues; Cheung, Alfred K; Lee, Vivian S
2014 Apr;85(4):768-778, Kidney international
— id: 900422, year: 2014, vol: 85, page: 768, stat: Journal Article,

Toward simultaneous PET/MR breast imaging: Systematic evaluation and integration of a radiofrequency breast coil
Aklan, Bassim; Paulus, Daniel H; Wenkel, Evelyn; Braun, Harald; Navalpakkam, Bharath K; Ziegler, Susanne; Geppert, Christian; Sigmund, Eric E; Melsaether, Amy; Quick, Harald H
2013 Feb;40(2):024301-024301, Medical physics
— id: 231652, year: 2013, vol: 40, page: 024301, stat: Journal Article,

Multiple-echo diffusion tensor acquisition technique (MEDITATE) on a 3T clinical scanner
Baete, Steven H; Cho, Gene; Sigmund, Eric E
2013 Nov;26(11):1471-1483, NMR in biomedicine
— id: 586182, year: 2013, vol: 26, page: 1471, stat: Journal Article,

Ductal Carcinoma in Situ of the Breasts: Review of MR Imaging Features
Greenwood, Heather I; Heller, Samantha L; Kim, Sungheon; Sigmund, Eric E; Shaylor, Sara D; Moy, Linda
2013 Oct;33(6):1569-1588, Radiographics
— id: 571422, year: 2013, vol: 33, page: 1569, stat: Journal Article,

A better characterization of spinal cord damage in multiple sclerosis: a diffusional kurtosis imaging study
Raz, E; Bester, M; Sigmund, E E; Tabesh, A; Babb, J S; Jaggi, H; Helpern, J; Mitnick, R J; Inglese, M
2013 Sep;34(9):1846-1852, AJNR. American journal of neuroradiology
— id: 528992, year: 2013, vol: 34, page: 1846, stat: Journal Article,

Utility of diffusional kurtosis imaging as a marker of adverse pathologic outcomes among prostate cancer active surveillance candidates undergoing radical prostatectomy
Rosenkrantz, Andrew B; Prabhu, Vinay; Sigmund, Eric E; Babb, James S; Deng, Fang-Ming; Taneja, Samir S
2013 Oct;201(4):840-846, American journal of roentgenology (1976)
— id: 542842, year: 2013, vol: 201, page: 840, stat: Journal Article,

Stimulated echo diffusion tensor imaging and SPAIR T(2) -weighted imaging in chronic exertional compartment syndrome of the lower leg muscles
Sigmund, Eric E; Sui, Dabang; Ukpebor, Obehi; Baete, Steven; Fieremans, Els; Babb, James S; Mechlin, Michael; Liu, Kecheng; Kwon, Jane; McGorty, Kellyanne; Hodnett, Philip A; Bencardino, Jenny
2013 Feb;:1073-1082, Journal of magnetic resonance imaging
— id: 231572, year: 2013, vol: , page: 1073, stat: Journal Article,

Renal Blood Oxygenation Level-Dependent Imaging: Contribution of R2 to R2* Values
Vivier, Pierre-Hugues; Storey, Pippa; Chandarana, Hersh; Yamamoto, Akira; Tantillo, Kristopher; Khan, Umer; Zhang, Jeff L; Sigmund, Eric E; Rusinek, Henry; Babb, James S; Bubenheim, Michael; Lee, Vivian S
2013 Feb;:501-508, Investigative radiology
— id: 231582, year: 2013, vol: , page: 501, stat: Journal Article,

Diffusion-Weighted Intravoxel Incoherent Motion Imaging of Renal Tumors With Histopathologic Correlation
Chandarana, Hersh; Kang, Stella K; Wong, Samson; Rusinek, Henry; Zhang, Jeff L; Arizono, Shigeki; Huang, William C; Melamed, Jonathan; Babb, James S; Suan, Edgar F; Lee, Vivian S; Sigmund, Eric E
2012 Sep;:688-696, Investigative radiology
— id: 179984, year: 2012, vol: , page: 688, stat: Journal Article,

A versatile flow phantom for intravoxel incoherent motion MRI
Cho GY; Kim S; Jensen JH; Storey P; Sodickson DK; Sigmund EE
2012 Nov 23;:1710-1720, Magnetic resonance in medicine
— id: 149836, year: 2012, vol: , page: 1710, stat: Journal Article,

Magnetic Resonance Characterization of Porous Media Using Diffusion through Internal Magnetic Fields
Cho, Hyung Joon; Sigmund, Eric E.; Song, Yiqiao
2012 APR;5(4):590-616, Materials
— id: 166849, year: 2012, vol: 5, page: 590, stat: Journal Article,

Interstitial fluid pressure correlates with intravoxel incoherent motion imaging metrics in a mouse mammary carcinoma model
Kim, S; Decarlo, L; Cho, GY; Jensen, JH; Sodickson, DK; Moy, L; Formenti, S; Schneider, RJ; Goldberg, JD; Sigmund, EE
2012 Nov;:787-794, NMR in biomedicine
— id: 160660, year: 2012, vol: , page: 787, stat: Journal Article,

Prostate Cancer: Feasibility and Preliminary Experience of a Diffusional Kurtosis Model for Detection and Assessment of Aggressiveness of Peripheral Zone Cancer
Rosenkrantz, AB; Sigmund, EE; Johnson, G; Babb, JS; Mussi, TC; Melamed, J; Taneja, SS; Lee, VS; Jensen, JH
2012 May;:126-135, Radiology
— id: 167146, year: 2012, vol: , page: 126, stat: Journal Article,

Assessment of hepatocellular carcinoma using apparent diffusion coefficient and diffusion kurtosis indices: preliminary experience in fresh liver explants
Rosenkrantz, Andrew B; Sigmund, Eric E; Winnick, Aaron; Niver, Benjamin E; Spieler, Bradley; Morgan, Glyn R; Hajdu, Cristina H
2012 Dec;30(10):1534-1540, Magnetic resonance imaging
— id: 180402, year: 2012, vol: 30, page: 1534, stat: Journal Article,

High-resolution human cervical spinal cord imaging at 7 T
Sigmund, E E; Suero, G A; Hu, C; McGorty, K; Sodickson, D K; Wiggins, G C; Helpern, J A
2012 Jul;25(7):891-899, NMR in biomedicine
— id: 169467, year: 2012, vol: 25, page: 891, stat: Journal Article,

Intravoxel Incoherent Motion and Diffusion-Tensor Imaging in Renal Tissue under Hydration and Furosemide Flow Challenges
Sigmund, EE; Vivier, PH; Sui, D; Lamparello, NA; Tantillo, K; Mikheev, A; Rusinek, H; Babb, JS; Storey, P; Lee, VS; Chandarana, H
2012 Apr;:758-769, Radiology
— id: 167147, year: 2012, vol: , page: 758, stat: Journal Article,

Optimization of b-value sampling for diffusion-weighted imaging of the kidney
Zhang JL; Sigmund EE; Rusinek H; Chandarana H; Storey P; Chen Q; Lee VS
2012 Jan;67(1):89-97, Magnetic resonance in medicine
— id: 135366, year: 2012, vol: 67, page: 89, stat: Journal Article,

Comparison of biexponential and monoexponential model of diffusion weighted imaging in evaluation of renal lesions: preliminary experience
Chandarana, Hersh; Lee, Vivian S; Hecht, Elizabeth; Taouli, Bachir; Sigmund, Eric E
2011 May;46(5):285-291, Investigative radiology
— id: 130291, year: 2011, vol: 46, page: 285, stat: Journal Article,

Magnetic resonance imaging of mixed ground glass nodules
Koo C.W.; Chen Q.C.; Sigmund E.E.; Mcgorty K.; Mason D.M.; Naidich D.P.
2011 ;26(3):W111-W111, Journal of thoracic imaging
— id: 136977, year: 2011, vol: 26, page: W111, stat: Journal Article,

Intravoxel incoherent motion imaging of tumor microenvironment in locally advanced breast cancer
Sigmund, E E; Cho, G Y; Kim, S; Finn, M; Moccaldi, M; Jensen, J H; Sodickson, D K; Goldberg, J D; Formenti, S; Moy, L
2011 May;65(5):1437-1447, Magnetic resonance in medicine
— id: 131795, year: 2011, vol: 65, page: 1437, stat: Journal Article,

Diffusion-weighted imaging of the brain at 7 T with echo-planar and turbo spin echo sequences: preliminary results
Sigmund, Eric E; Gutman, David
2011 Jul;29(6):752-765, Magnetic resonance imaging
— id: 135530, year: 2011, vol: 29, page: 752, stat: Journal Article,

[Functional MRI of the kidney]
Mannelli, Lorenzo; Valentino, Massimo; Laffi, Giacomo; Lomas, David J; Sigmund, Eric E; Raz, Eytan; Chandarana, Hersh
2010 Nov-Dec;27(6):599-608, Giornale italiano di nefrologia
— id: 119231, year: 2010, vol: 27, page: 599, stat: Journal Article,

Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: Preliminary experience
Patel, Jignesh; Sigmund, Eric E; Rusinek, Henry; Oei, Marcel; Babb, James S; Taouli, Bachir
2010 Mar;31(3):589-600, Journal of magnetic resonance imaging
— id: 107780, year: 2010, vol: 31, page: 589, stat: Journal Article,

Variability of renal apparent diffusion coefficients: limitations of the monoexponential model for diffusion quantification
Zhang, Jeff L; Sigmund, Eric E; Chandarana, Hersh; Rusinek, Henry; Chen, Qun; Vivier, Pierre-Hugues; Taouli, Bachir; Lee, Vivian S
2010 Mar;254(3):783-792, Radiology
— id: 111628, year: 2010, vol: 254, page: 783, stat: Journal Article,

T1 hyperintense renal lesions: characterization with diffusion-weighted mr imaging versus contrast-enhanced MR imaging
Kim, Sooah; Jain, Monica; Harris, Andrew B; Lee, Vivian S; Babb, James S; Sigmund, Eric E; Rueff, Laura E; Taouli, Bachir
2009 Jun;251(3):796-807, Radiology
— id: 99211, year: 2009, vol: 251, page: 796, stat: Journal Article,

High-resolution MRI of internal field diffusion-weighting in trabecular bone
Sigmund, E E; Cho, H; Song, Y-Q
2009 May;22(4):436-448, NMR in biomedicine
— id: 111667, year: 2009, vol: 22, page: 436, stat: Journal Article,

Diffusion-weighted MR imaging of the kidneys and the urinary tract
Kim, Sooah; Naik, Mohit; Sigmund, Eric; Taouli, Bachir
2008 Nov;16(4):266-280, Magnetic resonance imaging clinics of North America
— id: 91449, year: 2008, vol: 16, page: 266, stat: Journal Article,

Diffusion-based MR methods for bone structure and evolution
Sigmund, E E; Cho, H; Chen, P; Byrnes, S; Song, Y-Q; Guo, X E; Brown, T R
2008 Jan;59(1):28-39, Magnetic resonance in medicine
— id: 75489, year: 2008, vol: 59, page: 28, stat: Journal Article,

A single-scan method for measuring flow along an arbitrary direction
Cho, H; Ren, X-H; Sigmund, E E; Song, Y-Q
2007 May;186(1):11-16, Journal of magnetic resonance
— id: 74006, year: 2007, vol: 186, page: 11, stat: Journal Article,

Rapid measurement of three-dimensional diffusion tensor
Cho, H; Ren, X-H; Sigmund, E E; Song, Y-Q
2007 Apr 21;126(15):154501-154501, Journal of chemical physics
— id: 74005, year: 2007, vol: 126, page: 154501, stat: Journal Article,

Spatial heterogeneity length scales in carbonate rocks
Pomerantz, AE; Sigmund, EE; Song, YQ
2007 NOV ;32(1-2):221-231, Applied magnetic resonance
— id: 75491, year: 2007, vol: 32, page: 221, stat: Journal Article,

Multiple-modulation-multiple-echo magnetic resonance
Sigmund, EE; Cho, H; Song, YQ
2007 NOV ;30A(6):358-377, Concepts in magnetic resonance. Pt. A. Bridging education & research
— id: 75490, year: 2007, vol: 30A, page: 358, stat: Journal Article,

Anisotropy and penetration depth of MgB2 from B-11 NMR
Chen, B; Sengupta, P; Halperin, WP; Sigmund, EE; Mitrovic, VF; Lee, MH; Kang, KH; Mean, BJ; Kim, JY; Cho, BK
2006 NOV 16 ;8(1-2):221-231, New journal of physics
— id: 75492, year: 2006, vol: 8, page: 221, stat: Journal Article,

Stokes-Einstein relation in supercooled aqueous solutions of glycerol
Chen, Bo; Sigmund, E E; Halperin, W P
2006 Apr 14;96(14):145502-145502, Physical review letters
— id: 66477, year: 2006, vol: 96, page: 145502, stat: Journal Article,

Fast imaging with the MMME sequence
Cho, H; Chavez, L; Sigmund, E E; Madio, D P; Song, Y-Q
2006 May;180(1):18-28, Journal of magnetic resonance
— id: 66478, year: 2006, vol: 180, page: 18, stat: Journal Article,

Rapid T1 measurement via decay-recovery decomposition: applications in fringe field and distributed relaxation experiments
Sigmund, Eric E; Caudal, Nicolas; Song, Yi-Qiao
2006 Feb;29(1-3):232-241, Solid state nuclear magnetic resonance
— id: 66045, year: 2006, vol: 29, page: 232, stat: Journal Article,

Multiple echo diffusion tensor acquisition technique
Sigmund, Eric E; Song, Yi-Qiao
2006 Jan;24(1):7-18, Magnetic resonance imaging
— id: 66052, year: 2006, vol: 24, page: 7, stat: Journal Article,

NMR pore size measurements using an internal field in porous media
Song YQ; Sigmund EE; Lisitza NV
NMR imaging in chemical engineering Weinheim : Wiley-VCH, 2006,
— id: 4026, year: 2006, vol: , page: ?, stat: Chapter,

Simultaneous measurement of diffusion along multiple directions
Tang, Xiao-Ping; Sigmund, Eric E; Song, Yi-Qiao
2004 Dec 22;126(50):16336-16337, Journal of the American Chemical Society
— id: 66022, year: 2004, vol: 126, page: 16336, stat: Journal Article,

Alkali ion-cryptand interactions and their effects on electrolyte conductivity
Ding ZN; Ellis DE; Sigmund EE; Halperin WP; Shriver DF
2003 ;5:2072-2081, Physical chemistry chemical physics : PCCP
— id: 66486, year: 2003, vol: 5, page: 2072, stat: Journal Article,

Antiferromagnetism in the vortex cores of YBa2Cu307-delta
Mitrovic VF; Sigmund EE; Halperin WP; Reyes AP; Kuhns PL; Moulton WG
2003 ;67:220503-220503, Physical review. B. Condensed matter
— id: 66483, year: 2003, vol: 67, page: 220503, stat: Journal Article,

High field-gradient translational diffusion measurements in a bitter magnet
Sigmund EE; Halperin WP; Reyes AP; Kuhns PL; Moulton WG
2003 ;10(1):10-11, National High Magnetic Field Laboratory reports
— id: 66482, year: 2003, vol: 10, page: 10, stat: Journal Article,

Hole-burning diffusion measurements in high magnetic field gradients
Sigmund, E E; Halperin, W P
2003 Jul;163(1):99-104, Journal of magnetic resonance
— id: 66479, year: 2003, vol: 163, page: 99, stat: Journal Article,

Inductive shielding of NMR phase noise
Sigmund EE; Mitrovic VF; Calder ES; Thomas GW; Bachman HN; Halperin WP; Kuhns PL; Reyes AP
2002 ;159:190-194, Journal of magnetic resonance
— id: 66487, year: 2002, vol: 159, page: 190, stat: Journal Article,

Nuclear magnetic resonance study of ultraslow diffusion in electrolytes and glass-forming liquids
Sigmund, Eric E
[S.l. : s.n.], 2002,
— id: 1935, year: 2002, vol: , page: , stat: ,

Polar signal averaging
Thomas GW; Bachman HN; Sigmund EE; Mitrovic VF; Calder ES; Halperin WP
2002 ;14:359-364, Concepts in magnetic resonance. Pt. A. Bridging education & research
— id: 66488, year: 2002, vol: 14, page: 359, stat: Journal Article,

Spatially resolved electronic structure inside and outside the vortex cores of a high-temperature superconductor
Mitrovic VF; Sigmund EE; Eschrig M; Bachman HN; Halperin WP; Reyes AP; Kuhns P; Moulton WG
2001 Oct 4;413(6855):501-504, Nature
— id: 66480, year: 2001, vol: 413, page: 501, stat: Journal Article,

Progressive saturation NMR relaxation
Mitrovic VF; Sigmund EE; Halperin WP
2001 ;64:024520-024520, Physical review. B. Condensed matter
— id: 66485, year: 2001, vol: 64, page: 024520, stat: Journal Article,

NMR phase noise in bitter magnets
Sigmund EE; Calder ES; Thomas GW; Mitrovic VF; Bachman HN; Halperin WP; Kuhns PL; Reyes AP
2001 Feb;148(2):309-313, Journal of magnetic resonance
— id: 66481, year: 2001, vol: 148, page: 309, stat: Journal Article,

Lithium transport in a macrocyclic electrolyte
Sigmund EE; Halperin WP; Dillon REA; Shriver DF
2001 ;64:214201-214201, Physical review. B. Condensed matter
— id: 66484, year: 2001, vol: 64, page: 214201, stat: Journal Article,