Robert J Schneider

Biosketch / Results /

Robert Schneider

Albert B. Sabin Professor of Microbiology and Molecular Pathogenesis, Department of Microbiology
Professor, Department of Radiation Oncology

Associate Dean for Therapeutics Alliances

Contact Info

212-263-6006
Robert.Schneider@nyumc.org

Research Summary

I am an Associate Director of the NYU Cancer Institute, Director of Translational Cancer Research, and Co-director of the Breast Cancer Research Program at NYU School of Medicine. Our research is directed to three major areas: (1) the molecular and genetic understanding of advanced breast cancers and the development of new treatment strategies and therapeutics for advanced breast cancers, focusing particularly on the role of protein synthesis and mTOR kinase regulation; (2) the molecular understanding of gene regulation by ionizing radiation, particularly its ability to regulate protein synthesis and use of this knowledge for development of new cancer treatment strategies; and (3) regulation of the inflammatory response by targeted rapid degradation of inflammatory cytokine mRNAs, and the connection to cancer development and progression.

Research Interests

Breast cancer genetics and molecular biology, Post-transcriptional control of gene expression, role of protein synthesis in cancer development

Research Keywords

cancer, developmental genetics, genome integrity, microbiology, pharmacology, RNA biology, stem cell biology

mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy
Goldman, Kara N; Chenette, Devon; Arju, Rezina; Duncan, Francesca E; Keefe, David L; Grifo, Jamie A; Schneider, Robert J. mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017 Mar 7;114(12):3186-3191 (2476872)

mTORC1 and 2 coordinate transcriptional and translational reprogramming in resistance to DNA damage and replicative stress in breast cancer cells
Silvera, Deborah; Ernlund, Amanda; Arju, Rezina; Connolly, Eileen; Volta, Viviana; Wang, Jinhua; Schneider, Robert J. mTORC1 and 2 coordinate transcriptional and translational reprogramming in resistance to DNA damage and replicative stress in breast cancer cells. Molecular & cellular biology. 2017 Feb 15;37(5):?-? (2363362)

Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2
Dankert, John F; Rona, Gergely; Clijsters, Linda; Geter, Phillip; Skaar, Jeffrey R; Bermudez-Hernandez, Keria; Sassani, Elizabeth; Fenyo, David; Ueberheide, Beatrix; Schneider, Robert; Pagano, Michele. Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Molecular cell. 2016 Nov 03;64(3):507-519 (2288562)

MTOR inhibitors preserve fertility in a murine model: A novel pharmacologic approach to fertility preservation during gonadotoxic chemotherapy
Goldman, K N; Chenette, D; Keefe, D L; Grifo, J; Schneider, R J. MTOR inhibitors preserve fertility in a murine model: A novel pharmacologic approach to fertility preservation during gonadotoxic chemotherapy [Meeting Abstract]. Fertility & sterility. 2016 Sep;Conference:(ASRM):e2-e3 (2294472)

Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity
Chenette, Devon M; Cadwallader, Adam B; Antwine, Tiffany L; Larkin, Lauren C; Wang, Jinhua; Olwin, Bradley B; Schneider, Robert J. Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity. Cell reports. 2016 Aug 02;16(5):1379-1390 (2191382)