Robert J Schneider

Biosketch / Results /

Robert Schneider

Albert B. Sabin Professor of Microbiology and Molecular Pathogenesis, Department of Microbiology
Professor, Department of Radiation Oncology

Associate Dean for Therapeutics Alliances

Contact Info

212/263-6006
Robert.Schneider@nyumc.org

Research Summary

I am an Associate Director of the NYU Cancer Institute, Director of Translational Cancer Research, and Co-director of the Breast Cancer Research Program at NYU School of Medicine. Our research is directed to three major areas: (1) the molecular and genetic understanding of advanced breast cancers and the development of new treatment strategies and therapeutics for advanced breast cancers, focusing particularly on the role of protein synthesis and mTOR kinase regulation; (2) the molecular understanding of gene regulation by ionizing radiation, particularly its ability to regulate protein synthesis and use of this knowledge for development of new cancer treatment strategies; and (3) regulation of the inflammatory response by targeted rapid degradation of inflammatory cytokine mRNAs, and the connection to cancer development and progression.

Research Interests

Breast cancer genetics and molecular biology, Post-transcriptional control of gene expression, role of protein synthesis in cancer development

Research Keywords

cancer, developmental genetics, genome integrity, microbiology, pharmacology, RNA biology, stem cell biology

A long noncoding RNA associated with susceptibility to celiac disease
Castellanos-Rubio, Ainara; Fernandez-Jimenez, Nora; Kratchmarov, Radomir; Luo, Xiaobing; Bhagat, Govind; Green, Peter H R; Schneider, Robert; Kiledjian, Megerditch; Bilbao, Jose Ramon; Ghosh, Sankar. A long noncoding RNA associated with susceptibility to celiac disease. Science. 2016 Apr 1;352(6281):91-95 (2059302)

Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity
Chenette, Devon M; Cadwallader, Adam B; Antwine, Tiffany L; Larkin, Lauren C; Wang, Jinhua; Olwin, Bradley B; Schneider, Robert J. Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity. Cell reports. 2016 Jul 21;16(5):1379-1390 (2191382)

Endothelin-1 in the tumor microenvironment correlates with melanoma invasion
Chiriboga, Luis; Meehan, Shane; Osman, Iman; Glick, Michael; de la Cruz, Gelo; Howell, Brittny S; Friedman-Jimenez, George; Schneider, Robert J; Jamal, Sumayah. Endothelin-1 in the tumor microenvironment correlates with melanoma invasion. Melanoma research. 2016 Jun ;26(3):236-244 (1929752)

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation
Daniels, Garrett; Zhang, Xinmin; Zhong, Xuelin; Santiago, Larion; Wang, Ling Hang; Wu, Xinyu; Zhang, Jack Y; Liang, Fengxia; Li, Xin; Neubert, Thomas A; Steinke, Laurey; Shen, Ying; Basch, Ross; Schneider, Robert; Levy, David E; Lee, Peng. Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation. Oncotarget. 2016 Jun 28;7(26):39556-39571 (2092672)

Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2
Dankert, John F; Rona, Gergely; Clijsters, Linda; Geter, Phillip; Skaar, Jeffrey R; Bermudez-Hernandez, Keria; Sassani, Elizabeth; Fenyo, David; Ueberheide, Beatrix; Schneider, Robert; Pagano, Michele. Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Molecular cell. 2016 Oct 20;64(3):507-519 (2288562)