Helen E. Scharfman

Biosketch / Results /

Helen E. Scharfman, Ph.D.

Professor;
Departments of Child and Adolescent Psychiatry (Hoagwood Rsch), Neuroscience and Physiology (Neuro/Phys) and Psychiatry

Contact Info

Address

Floor 8 Room 8-434.2
1 Park Avenue
, NY

845-398-5427
Helen.Scharfman@nyumc.org

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Education

1977-1981 — Vassar College, Graduate Education
1986 — Uniformed Services Univ, Graduate Education

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Research Interests

1. Hippocampus and parahippocampal areas, their role in normal function and their contribution to neurological disorders and mental illness. 2. Neurotrophins (BDNF)and neuronal plasticity 3. Neurogenesis in the dentate gyrus 3. Mechanisms controlling neuronal excitability; seizures; epilepsy. 4. Neuronal modulation by reproductive steroids 5. Brain and spinal cord injury; neuroprotection

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age
Duffy, Aine M; Morales-Corraliza, Jose; Bermudez-Hernandez, Keria M; Schaner, Michael J; Magagna-Poveda, Alejandra; Mathews, Paul M; Scharfman, Helen E
2014 Jul;:1-6, Neurobiology of aging
— id: 1141552, year: 2014, vol: , page: 1, stat: Journal Article,

How can we identify ictal and interictal abnormal activity?
Fisher, Robert S; Scharfman, Helen E; deCurtis, Marco
2014 ;813:3-23, Advances in experimental medicine & biology
— id: 1074892, year: 2014, vol: 813, page: 3, stat: Journal Article,

Suppression of Adult Neurogenesis Increases the Acute Effects of Kainic Acid
Iyengar, Sloka S; LaFrancois, John J; Friedman, Daniel; Drew, Liam J; Denny, Christine A; Burghardt, Nesha S; Wu, Melody V; Hsieh, Jenny; Hen, Rene; Scharfman, Helen E
2014 Dec;:1595-1601, Experimental neurology
— id: 1371222, year: 2014, vol: , page: 1595, stat: Journal Article,

Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce, Patrice S; Friedman, Daniel; Lafrancois, John J; Iyengar, Sloka S; Fenton, Andre A; Maclusky, Neil J; Scharfman, Helen E
2014 Mar;32:121-131, Epilepsy & behavior
— id: 829482, year: 2014, vol: 32, page: 121, stat: Journal Article,

Is plasticity of GABAergic mechanisms relevant to epileptogenesis?
Scharfman, Helen E; Brooks-Kayal, Amy R
2014 ;813:133-150, Advances in experimental medicine & biology
— id: 1074902, year: 2014, vol: 813, page: 133, stat: Journal Article,

Preface
Scharfman, Helen E; Buckmaster, Paul S
2014 ;813:xv-xviii, Advances in experimental medicine & biology
— id: 1341192, year: 2014, vol: 813, page: xv, stat: Journal Article,

Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats
Scharfman, Helen E; Maclusky, Neil J
2014 Jan;76 Pt C:696-708, Neuropharmacology
— id: 680892, year: 2014, vol: 76 Pt C, page: 696, stat: Journal Article,

Sex differences in the neurobiology of epilepsy: A preclinical perspective
Scharfman, Helen E; MacLusky, Neil J
2014 Jul;:1-5, Neurobiology of disease
— id: 1076192, year: 2014, vol: , page: 1, stat: Journal Article,

Sex differences in the neurobiology of epilepsy: A preclinical perspective
Scharfman, Helen E; MacLusky, Neil J
2014 DEC;72:180-192, Neurobiology of disease
— id: 1395392, year: 2014, vol: 72, page: 180, stat: Journal Article,

p75NTR, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
VonDran, Melissa W; LaFrancois, John; Padow, Victoria A; Friedman, Wilma J; Scharfman, Helen E; Milner, Teresa A; Hempstead, Barbara L
2014 ;6(5):?-? e97, ASN neuro
— id: 1299872, year: 2014, vol: 6, page: ?, stat: Journal Article,

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus
Yang, Jianmin; Harte-Hargrove, Lauren C; Siao, Chia-Jen; Marinic, Tina; Clarke, Roshelle; Ma, Qian; Jing, Deqiang; Lafrancois, John J; Bath, Kevin G; Mark, Willie; Ballon, Douglas; Lee, Francis S; Scharfman, Helen E; Hempstead, Barbara L
2014 May;7(3):796-806, Cell reports
— id: 996552, year: 2014, vol: 7, page: 796, stat: Journal Article,

Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research
Bath, Kevin G; Scharfman, Helen E
2013 Mar;26(3):427-439, Epilepsy & behavior
— id: 829842, year: 2013, vol: 26, page: 427, stat: Journal Article,

Behavioral and neuroendocrine assays for studying epilepsy-associated depression Response
Brooks-Kayal, Amy R.; Bath, Kevin G.; Berg, Anne T.; Galanopoulou, Aristea S.; Holmes, Gregory L.; Jensen, Frances E.; Kanner, Andres M.; O'Brien, Terence J.; Whittemore, Vicky H.; Winawer, Melodie R.; Patel, Manisha; Scharfman, Helen E.
2013 DEC;54(12):2229-2230, Epilepsia
— id: 700892, year: 2013, vol: 54, page: 2229, stat: Journal Article,

Authors' response to letter by A. Mazarati
Brooks-Kayal, Amy R; Bath, Kevin G; Berg, Anne T; Galanopoulou, Aristea S; Holmes, Gregory L; Jensen, Frances E; Kanner, Andres M; O'Brien, Terence J; Whittemore, Vicky H; Winawer, Melodie R; Patel, Manisha; Scharfman, Helen E
2013 Dec;54(12):2229-2230, Epilepsia
— id: 829792, year: 2013, vol: 54, page: 2229, stat: Journal Article,

Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy
Brooks-Kayal, Amy R; Bath, Kevin G; Berg, Anne T; Galanopoulou, Aristea S; Holmes, Gregory L; Jensen, Frances E; Kanner, Andres M; O'Brien, Terence J; Whittemore, Vicky H; Winawer, Melodie R; Patel, Manisha; Scharfman, Helen E
2013 Aug;54 Suppl 4:44-60, Epilepsia
— id: 829812, year: 2013, vol: 54 Suppl 4, page: 44, stat: Journal Article,

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms
Chin, Jeannie; Scharfman, Helen E
2013 Mar;26(3):343-351, Epilepsy & behavior
— id: 829832, year: 2013, vol: 26, page: 343, stat: Journal Article,

Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo
Duffy, Aine M; Schaner, Michael J; Chin, Jeannie; Scharfman, Helen E
2013 Aug;23(8):649-655, Hippocampus
— id: 515922, year: 2013, vol: 23, page: 649, stat: Journal Article,

Corrigendum to "Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus" [Neurobiol. Dis. 26/1 (2007) 174-188]
Howell, Owain W; Silva, Sharmalene; Scharfman, Helen E; Sosunov, Alexander A; Zaben, Malik; Shtaya, Anan; Mckhann, Guy 2nd; Herzog, Herbert; Laskowski, Alexandra; Gray, William P
2013 Jan;49:199-199, Neurobiology of disease
— id: 1310182, year: 2013, vol: 49, page: 199, stat: Journal Article,

The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function
Myers, Catherine E; Bermudez-Hernandez, Keria; Scharfman, Helen E
2013 ;8(6):e68208-e68208 e68208, PLoS one
— id: 829822, year: 2013, vol: 8, page: e68208, stat: Journal Article,

Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.)
Scharfman, Helen E
2013 Dec;38(11):3552-3553, European journal of neuroscience
— id: 829802, year: 2013, vol: 38, page: 3552, stat: Journal Article,

Preface to the Special Issue entitled "The Future of Translational Epilepsy Research"
Scharfman, Helen E
2013 Mar;26(3):209-209, Epilepsy & behavior
— id: 242222, year: 2013, vol: 26, page: 209, stat: Journal Article,

Aquaporin-4 water channels and synaptic plasticity in the hippocampus
Scharfman, Helen E; Binder, Devin K
2013 Dec;63(7):702-711, Neurochemistry international
— id: 626702, year: 2013, vol: 63, page: 702, stat: Journal Article,

The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders
Scharfman, Helen E; Chao, Moses V
2013 Sep-Dec;4(3-4):123-135, Cognitive neuroscience
— id: 652262, year: 2013, vol: 4, page: 123, stat: Journal Article,

Testosterone Depletion in Adult Male Rats Increases Mossy Fiber Transmission, LTP, and Sprouting in Area CA3 of Hippocampus
Skucas, Vanessa A; Duffy, Aine M; Harte-Hargrove, Lauren C; Magagna-Poveda, Alejandra; Radman, Thomas; Chakraborty, Goutam; Schroeder, Charles E; Maclusky, Neil J; Scharfman, Helen E
2013 Feb;33(6):2338-2355, Journal of neuroscience
— id: 240802, year: 2013, vol: 33, page: 2338, stat: Journal Article,

Reduced Hippocampal Brain-Derived Neurotrophic Factor (BDNF) in Neonatal Rats after Prenatal Exposure to Propylthiouracil (PTU)
Chakraborty, Goutam; Magagna-Poveda, Alejandra; Parratt, Carolyn; Umans, Jason G; Maclusky, Neil J; Scharfman, Helen E
2012 Mar;153(3):1311-1316, Endocrinology
— id: 160240, year: 2012, vol: 153, page: 1311, stat: Journal Article,

BDNF-estrogen interactions in hippocampal mossy fiber pathway: implications for normal brain function and disease
Harte-Hargrove, Lauren; Maclusky, Neil J; Scharfman, Helen E
2012 Dec;:46-66, Neuroscience
— id: 210432, year: 2012, vol: , page: 46, stat: Journal Article,

Cognitive detection of preclinical Alzheimer's disease
Lau, H; Karantzoulis, S; Myers, C; Pirraglia, E; Li, Y; Gurnani, A; Glodzik, L; Scharfman, H; Kesner, R; De, Leon M; Ferris, S
2012 2012;8(4):P358-P358, Alzheimer's & dementia
— id: 178085, year: 2012, vol: 8, page: P358, stat: Journal Article,

Early cognitive experience prevents adult deficits in a neurodevelopmental schizophrenia model
Lee, Heekyung; Dvorak, Dino; Kao, Hsin-Yi; Duffy, Aine M; Scharfman, Helen E; Fenton, Andre A
2012 Aug;75(4):714-724, Neuron
— id: 182022, year: 2012, vol: 75, page: 714, stat: Journal Article,

Temporal lobe epilepsy and BDNF Receptor, TrkB
McNamara, J.O.; Scharfman, H.E.
Jasper New York : Oxford University Press, 2012,
— id: 210492, year: 2012, vol: , page: ?, stat: Chapter,

Alzheimer's disease and epilepsy: insight from animal models
McNamara, James O.; Scharfman, Helen E.; Scharfman, Helen E
2012 Mar;7(2):177-192, Future neurology
— id: 210452, year: 2012, vol: 7, page: 177, stat: Journal Article,

Introduction to 'steroid hormone actions in the CNS: The role of brain-derived neurotrophic factor (BDNF)'
Scharfman, H E; Kramer, E A; Luine, V; Srivastava, D P
2012 Nov;:1-2, Neuroscience
— id: 210482, year: 2012, vol: , page: 1, stat: Journal Article,

"Untangling" Alzheimer's disease and epilepsy
Scharfman, Helen E
2012 Sep;12(5):178-183, Epilepsy currents
— id: 210442, year: 2012, vol: 12, page: 178, stat: Journal Article,

New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction
Scharfman, Helen E.; Pierce, Joseph P.
2012 JUN;53 1 1(SI):98-108, Epilepsia
— id: 169426, year: 2012, vol: 53 1 1, page: 98, stat: Journal Article,

Hilar mossy cells of the dentate gyrus: a historical perspective
Scharfman, Helen E; Myers, Catherine E
2012 ;6:106-106, Frontiers in neural circuits
— id: 223272, year: 2012, vol: 6, page: 106, stat: Journal Article,

New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction
Scharfman, Helen E; Pierce, Joseph P
2012 Jun;53 Suppl 1:109-115, Epilepsia
— id: 167509, year: 2012, vol: 53 Suppl 1, page: 109, stat: Journal Article,

Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design
Simonato, Michele; Loscher, Wolfgang; Cole, Andrew J; Dudek, F Edward; Engel, Jerome Jr; Kaminski, Rafal M; Loeb, Jeffrey A; Scharfman, Helen; Staley, Kevin J; Velisek, Libor; Klitgaard, Henrik
2012 Nov;53(11):1860-1867, Epilepsia
— id: 214682, year: 2012, vol: 53, page: 1860, stat: Journal Article,

17beta-estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus
Barouk, Sharon; Hintz, Tana; Li, Ping; Duffy, Aine M; MacLusky, Neil J; Scharfman, Helen E
2011 May;152(5):1745-1751, Endocrinology
— id: 134250, year: 2011, vol: 152, page: 1745, stat: Journal Article,

A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons
Duffy, Aine M; Schaner, Michael J; Wu, Synphen H; Staniszewski, Agnieszka; Kumar, Asok; Arevalo, Juan Carlos; Arancio, Ottavio; Chao, Moses V; Scharfman, Helen E
2011 Jun;229(2):409-420, Experimental neurology
— id: 145797, year: 2011, vol: 229, page: 409, stat: Journal Article,

Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures
McCloskey, Daniel P; Scharfman, Helen E
2011 Nov;97(1-2):92-102, Epilepsy research
— id: 210462, year: 2011, vol: 97, page: 92, stat: Journal Article,

Pattern separation in the dentate gyrus: A role for the CA3 backprojection
Myers CE; Scharfman HE
2011 Nov;21(11):1190-1215, Hippocampus
— id: 138349, year: 2011, vol: 21, page: 1190, stat: Journal Article,

Morphometry of hilar ectopic granule cells in the rat
Pierce, Joseph P; McCloskey, Daniel P; Scharfman, Helen E
2011 Apr 15;519(6):1196-1218, Journal of comparative neurology
— id: 134213, year: 2011, vol: 519, page: 1196, stat: Journal Article,

Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4
Skucas VA; Mathews IB; Yang J; Cheng Q; Treister A; Duffy AM; Verkman AS; Hempstead BL; Wood MA; Binder DK; Scharfman HE
2011 Apr 27;31(17):6392-6397, Journal of neuroscience
— id: 134260, year: 2011, vol: 31, page: 6392, stat: Journal Article,

Protective role of aquaporin-4 water channels after contusion spinal cord injury
Kimura, Atsushi; Hsu, Mike; Seldin, Marcus; Verkman, Alan S; Scharfman, Helen E; Binder, Devin K
2010 Jun;67(6):794-801, Annals of neurology
— id: 114777, year: 2010, vol: 67, page: 794, stat: Journal Article,

Seizing an opportunity: broader definitions of epilepsy may lead to better treatments
Scharfman, Helen E
2010 Sep;2010:18-18, Cerebrum : the Dana forum on brain science
— id: 829852, year: 2010, vol: 2010, page: 18, stat: Journal Article,

Seizing an Opportunity: Broader Definitions of Epilepsy May Lead to Better Treatments
Scharfman, Helen E
2010 Sep;2010:651-661, Cerebrum : the Dana forum on brain science
— id: 1065082, year: 2010, vol: 2010, page: 651, stat: Journal Article,

Dynamics of Active Sensing and perceptual selection
Schroeder, Charles E; Wilson, Donald A; Radman, Thomas; Scharfman, Helen; Lakatos, Peter
2010 Apr;20(2):172-176, Current opinion in neurobiology
— id: 114778, year: 2010, vol: 20, page: 172, stat: Journal Article,

A role for hilar cells in pattern separation in the dentate gyrus: A computational approach
Myers, Catherine E; Scharfman, Helen E
2009 Apr;19(4):321-337, Hippocampus
— id: 94640, year: 2009, vol: 19, page: 321, stat: Journal Article,

A Rat Model of Epilepsy in Women: a Tool to Study Physiological Interactions Between Endocrine Systems and Seizures
Scharfman, Helen E; Malthankar-Phatak, Gauri H; Friedman, Daniel; Pearce, Patrice; McCloskey, Daniel P; Harden, Cynthia L; Maclusky, Neil J
2009 Sep;150(9):4437-4442, Endocrinology
— id: 100035, year: 2009, vol: 150, page: 4437, stat: Journal Article,

Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy
Scharfman, Helen E; McCloskey, Daniel P
2009 Aug;85(2-3):150-161, Epilepsy research
— id: 108180, year: 2009, vol: 85, page: 150, stat: Journal Article,

THE SPATIAL RELATIONSHIP OF HIPPOCAMPAL INTERICTAL DISCHARGES AND HIGH FREQUENCY OSCILLATIONS IN VIVO IN A RAT MODEL OF TEMPORAL LOBE EPILEPSY
Friedman, D; Schevon, CA; Emerson, RG; Scharfman, H
2008 DEC ;49(12):170-170, Epilepsia
— id: 91392, year: 2008, vol: 49, page: 170, stat: Journal Article,

Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)
Macbeth, Abbe H; Scharfman, Helen E; Maclusky, Neil J; Gautreaux, Claris; Luine, Victoria N
2008 Jun;54(1):7-17, Hormones & behavior
— id: 76101, year: 2008, vol: 54, page: 7, stat: Journal Article,

Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effects
McCloskey, Daniel P; Hintz, Tana M; Scharfman, Helen E
2008 May 15;76(1-2):36-44, Brain research bulletin
— id: 94641, year: 2008, vol: 76, page: 36, stat: Journal Article,

Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus
Nicoletti, J N; Shah, S K; McCloskey, D P; Goodman, J H; Elkady, A; Atassi, H; Hylton, D; Rudge, J S; Scharfman, H E; Croll, S D
2008 Jan 2;151(1):232-241, Neuroscience
— id: 76099, year: 2008, vol: 151, page: 232, stat: Journal Article,

Estrogen-growth factor interactions and their contributions to neurological disorders
Scharfman, Helen E; MacLusky, Neil J
2008 Jul;48 Suppl 2:S77-S89, Headache
— id: 93351, year: 2008, vol: 48 Suppl 2, page: S77, stat: Journal Article,

Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus
Howell, Owain W; Silva, Sharmalene; Scharfman, Helen E; Sosunov, Alexander A; Zaben, Malik; Shatya, Anan; McKhann, Guy 2nd; Herzog, Herbert; Laskowski, Alexandra; Gray, William P
2007 Apr;26(1):174-188, Neurobiology of disease
— id: 73471, year: 2007, vol: 26, page: 174, stat: Journal Article,

Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures
Pierce, Joseph P; Punsoni, Michael; McCloskey, Daniel P; Scharfman, Helen E
2007 Jul 11;422(2):136-140, Neuroscience letters
— id: 73474, year: 2007, vol: 422, page: 136, stat: Journal Article,

The dentate gyrus : a comprehensive guide to structure function and clinical implications
Scharfman, Helen E
Amsterdam : Elsevier, 2007,
— id: 1379, year: 2007, vol: , page: , stat: ,

The CA3 "backprojection" to the dentate gyrus
Scharfman, Helen E
2007 ;163:627-637, Progress in brain research
— id: 76103, year: 2007, vol: 163, page: 627, stat: Journal Article,

The neurobiology of epilepsy
Scharfman, Helen E
2007 Jul;7(4):348-354, Current neurology & neuroscience reports
— id: 73476, year: 2007, vol: 7, page: 348, stat: Journal Article,

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy
Scharfman, Helen E; Gray, William P
2007 ;48 Suppl 2:33-41, Epilepsia
— id: 73473, year: 2007, vol: 48 Suppl 2, page: 33, stat: Journal Article,

Neuroscience. Is more neurogenesis always better?
Scharfman, Helen E; Hen, Rene
2007 Jan 19;315(5810):336-338, Science
— id: 73470, year: 2007, vol: 315, page: 336, stat: Journal Article,

Changes in hippocampal function of ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surge
Scharfman, Helen E; Hintz, Tana M; Gomez, Juan; Stormes, Kerry A; Barouk, Sharon; Malthankar-Phatak, Gauri H; McCloskey, Daniel P; Luine, Victoria N; Maclusky, Neil J
2007 Nov;26(9):2595-2612, European journal of neuroscience
— id: 76100, year: 2007, vol: 26, page: 2595, stat: Journal Article,

Ectopic granule cells of the rat dentate gyrus
Scharfman, Helen; Goodman, Jeffrey; McCloskey, Daniel
2007 ;29(1-2):14-27, Developmental neuroscience
— id: 73469, year: 2007, vol: 29, page: 14, stat: Journal Article,

Acute and chronic changes in glycogen phosphorylase in hippocampus and entorhinal cortex after status epilepticus in the adult male rat
Walling, Susan G; Rigoulot, Marie-Aude; Scharfman, Helen E
2007 Jul;26(1):178-189, European journal of neuroscience
— id: 73475, year: 2007, vol: 26, page: 178, stat: Journal Article,

Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice
Winawer, M R; Makarenko, N; McCloskey, D P; Hintz, T M; Nair, N; Palmer, A A; Scharfman, H E
2007 Oct 26;149(2):465-475, Neuroscience
— id: 76102, year: 2007, vol: 149, page: 465, stat: Journal Article,

Molecular mechanisms of dentate gyrus granule cell resistance to seizure-induced damage
Wu, SH; Arevalo, JC; Malthankar-Phatak, GH; Hintz, TM; McCloskey, DP; Tessarollo, L; Chao, MV; Scharfman, HE
2007 OCT ;48(1):241-241, Epilepsia
— id: 87154, year: 2007, vol: 48, page: 241, stat: Journal Article,

Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat
McCloskey, Daniel P; Hintz, Tana M; Pierce, Joseph P; Scharfman, Helen E
2006 Oct;24(8):2203-2210, European journal of neuroscience
— id: 73467, year: 2006, vol: 24, page: 2203, stat: Journal Article,

Preface
Scharfman H
2006 Dec;27(4):361-362, Frontiers in neuroendocrinology
— id: 73472, year: 2006, vol: 27, page: 361, stat: Journal Article,

Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis
Scharfman, Helen E; Gray, William P
2006 ;(95):193-211, EXS
— id: 73464, year: 2006, vol: , page: 193, stat: Journal Article,

The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female
Scharfman, Helen E; MacLusky, Neil J
2006 Sep;47(9):1423-1440, Epilepsia
— id: 73465, year: 2006, vol: 47, page: 1423, stat: Journal Article,

Growth factors and epilepsy
Binder, Devin K; Scharfman, Helen E
New York : Nova Science, 2005,
— id: 1380, year: 2005, vol: , page: , stat: ,

Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus
Howell, Owain W; Doyle, Kharen; Goodman, Jeffrey H; Scharfman, Helen E; Herzog, Herbert; Pringle, Ashley; Beck-Sickinger, Annette G; Gray, William P
2005 May;93(3):560-570, Journal of neurochemistry
— id: 73454, year: 2005, vol: 93, page: 560, stat: Journal Article,

Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures
McCloskey, Daniel P; Croll, Susan D; Scharfman, Helen E
2005 Sep 28;25(39):8889-8897, Journal of neuroscience
— id: 73460, year: 2005, vol: 25, page: 8889, stat: Journal Article,

Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures
Pierce, Joseph P; Melton, Jay; Punsoni, Michael; McCloskey, Daniel P; Scharfman, Helen E
2005 Dec;196(2):316-331, Experimental neurology
— id: 73463, year: 2005, vol: 196, page: 316, stat: Journal Article,

Brain-derived Neurotrophic Factor and Epilepsy-A Missing Link?
Scharfman, Helen E
2005 May-Jun;5(3):83-88, Epilepsy currents
— id: 73458, year: 2005, vol: 5, page: 83, stat: Journal Article,

The Absence of Information about Hormones and Absence
Scharfman, Helen E
2005 May-Jun;5(3):101-103, Epilepsy currents
— id: 73459, year: 2005, vol: 5, page: 101, stat: Journal Article,

Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine
Scharfman, Helen E; Goodman, Jeffrey H; Rigoulot, Marie-Aude; Berger, Russell E; Walling, Susan G; Mercurio, Thomas C; Stormes, Kerry; Maclusky, Neil J
2005 Nov;196(1):73-86, Experimental neurology
— id: 73457, year: 2005, vol: 196, page: 73, stat: Journal Article,

Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue?
Scharfman, Helen E; Maclusky, Neil J
2005 Feb;28(2):79-85, Trends in neurosciences
— id: 73452, year: 2005, vol: 28, page: 79, stat: Journal Article,

Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
Scharfman, Helen; Goodman, Jeffrey; Macleod, Adam; Phani, Sudar; Antonelli, Cara; Croll, Susan
2005 Apr;192(2):348-356, Experimental neurology
— id: 73453, year: 2005, vol: 192, page: 348, stat: Journal Article,

A woman's prerogative
Staley, Kevin; Scharfman, Helen
2005 Jun;8(6):697-699, Nature neuroscience
— id: 73455, year: 2005, vol: 8, page: 697, stat: Journal Article,

Synaptic plasticity and transsynaptic signaling
Stanton, Patric K; Bramham, Clive; Scharfman, Helen E
New York : Springer, 2005,
— id: 1378, year: 2005, vol: , page: , stat: ,

Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats
Wu, Hui-Qiu; Rassoulpour, Arash; Goodman, Jeffrey H; Scharfman, Helen E; Bertram, Edward H; Schwarcz, Robert
2005 Jul;46(7):1010-1016, Epilepsia
— id: 73456, year: 2005, vol: 46, page: 1010, stat: Journal Article,

Recent advances in epilepsy research
Binder, Devin K; Scharfman, Helen E
New York : Kluwer Academic, 2004,
— id: 1376, year: 2004, vol: , page: , stat: ,

Brain-derived neurotrophic factor
Binder, Devin K; Scharfman, Helen E
2004 Sep;22(3):123-131, Growth factors
— id: 73451, year: 2004, vol: 22, page: 123, stat: Journal Article,

Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword
Croll, Susan D; Goodman, Jeffrey H; Scharfman, Helen E
2004 ;548:57-68, Advances in experimental medicine & biology
— id: 73441, year: 2004, vol: 548, page: 57, stat: Journal Article,

Functional implications of seizure-induced neurogenesis
Scharfman, Helen E
2004 ;548:192-212, Advances in experimental medicine & biology
— id: 73442, year: 2004, vol: 548, page: 192, stat: Journal Article,

Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells
Howell, Owain W; Scharfman, Helen E; Herzog, Herbert; Sundstrom, Lars E; Beck-Sickinger, Annette; Gray, William P
2003 Aug;86(3):646-659, Journal of neurochemistry
— id: 73435, year: 2003, vol: 86, page: 646, stat: Journal Article,

Insight into Molecular Mechanisms of Catamenial Epilepsy
Scharfman HE
2003 May;3(3):86-88, Epilepsy currents
— id: 73443, year: 2003, vol: 3, page: 86, stat: Journal Article,

Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures
Scharfman, H E; Sollas, A E; Berger, R E; Goodman, J H; Pierce, J P
2003 ;121(4):1017-1029, Neuroscience
— id: 73439, year: 2003, vol: 121, page: 1017, stat: Journal Article,

Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor
Scharfman, Helen E; Mercurio, Thomas C; Goodman, Jeffrey H; Wilson, Marlene A; MacLusky, Neil J
2003 Dec 17;23(37):11641-11652, Journal of neuroscience
— id: 73440, year: 2003, vol: 23, page: 11641, stat: Journal Article,

Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting
Scharfman, Helen E; Sollas, Anne L; Berger, Russell E; Goodman, Jeffrey H
2003 Oct;90(4):2536-2547, Journal of neurophysiology
— id: 73438, year: 2003, vol: 90, page: 2536, stat: Journal Article,

A Novel Animal Model of Epilepsy Caused by Inhibiting Neuronal Activity during Development
Scharfman H
2002 Jul;2(4):127-128, Epilepsy currents
— id: 73448, year: 2002, vol: 2, page: 127, stat: Journal Article,

Does BDNF Contribute to Temporal Lobe Epilepsy?
Scharfman H
2002 May;2(3):92-94, Epilepsy currents
— id: 73449, year: 2002, vol: 2, page: 92, stat: Journal Article,

Grafts of Encapsulated Fibroblasts Engineered to Release an Anticonvulsant Substance
Scharfman H
2002 Jul;2(4):125-126, Epilepsy currents
— id: 73447, year: 2002, vol: 2, page: 125, stat: Journal Article,

The "Reel" Pathology of Temporal Lobe Epilepsy
Scharfman H
2002 Nov;2(6):196-197, Epilepsy currents
— id: 73444, year: 2002, vol: 2, page: 196, stat: Journal Article,

Upregulation of Multidrug Resistance Transporters in the Epileptic Brain
Scharfman H
2002 Nov;2(6):200-202, Epilepsy currents
— id: 73445, year: 2002, vol: 2, page: 200, stat: Journal Article,

Does the Development of a GABAergic Phenotype by Hippocampal Dentate Gyrus Granule Cells Contribute to Epileptogenesis
Scharfman HE
2002 Mar;2(2):63-63, Epilepsy currents
— id: 73450, year: 2002, vol: 2, page: 63, stat: Journal Article,

Keeping Pace with Pacemaker Channels
Scharfman HE
2002 Sep;2(5):155-156, Epilepsy currents
— id: 73446, year: 2002, vol: 2, page: 155, stat: Journal Article,

Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus
Scharfman, H E; Sollas, A L; Goodman, J H
2002 ;111(1):71-81, Neuroscience
— id: 73432, year: 2002, vol: 111, page: 71, stat: Journal Article,

Epilepsy as an example of neural plasticity
Scharfman, Helen E
2002 Apr;8(2):154-173, Neuroscientist
— id: 73431, year: 2002, vol: 8, page: 154, stat: Journal Article,

Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor
Scharfman, Helen E; Goodman, Jeffrey H; Sollas, Anne L; Croll, Susan D
2002 Apr;174(2):201-214, Experimental neurology
— id: 73430, year: 2002, vol: 174, page: 201, stat: Journal Article,

Structural and functional asymmetry in the normal and epileptic rat dentate gyrus
Scharfman, Helen E; Sollas, Anne L; Smith, Karen L; Jackson, Meyer B; Goodman, Jeffrey H
2002 Dec 23;454(4):424-439, Journal of comparative neurology
— id: 73434, year: 2002, vol: 454, page: 424, stat: Journal Article,

L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat
Wu, Hui-Qui; Lee, Song-Chu; Scharfman, Helen E; Schwarcz, Robert
2002 Sep;177(1):222-232, Experimental neurology
— id: 73433, year: 2002, vol: 177, page: 222, stat: Journal Article,

BDNF and epilepsy: too much of a good thing?
Binder, D K; Croll, S D; Gall, C M; Scharfman, H E
2001 Jan;24(1):47-53, Trends in neurosciences
— id: 73428, year: 2001, vol: 24, page: 47, stat: Journal Article,

Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells
Scharfman, H E; Smith, K L; Goodman, J H; Sollas, A L
2001 ;104(3):741-759, Neuroscience
— id: 73429, year: 2001, vol: 104, page: 741, stat: Journal Article,

Epileptogenesis in the parahippocampal region. Parallels with the dentate gyrus
Scharfman, H E
2000 Jun;911:305-327, Annals of the New York Academy of Sciences
— id: 73425, year: 2000, vol: 911, page: 305, stat: Journal Article,

Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro
Scharfman, H E; Goodman, J H; Schwarcz, R
2000 ;19(1):283-297, Amino acids
— id: 73427, year: 2000, vol: 19, page: 283, stat: Journal Article,

Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
Scharfman, H E; Goodman, J H; Sollas, A L
2000 Aug 15;20(16):6144-6158, Journal of neuroscience
— id: 73426, year: 2000, vol: 20, page: 6144, stat: Journal Article,

The parahippocampal region. Implications for neurological and psychiatric diseases. Introduction
Scharfman, H E; Witter, M P; Schwarcz, R
2000 Jun;911:ix-xiii, Annals of the New York Academy of Sciences
— id: 73424, year: 2000, vol: 911, page: ix, stat: Journal Article,

Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo
Wu, H Q; Guidetti, P; Goodman, J H; Varasi, M; Ceresoli-Borroni, G; Speciale, C; Scharfman, H E; Schwarcz, R
2000 ;97(2):243-251, Neuroscience
— id: 73423, year: 2000, vol: 97, page: 243, stat: Journal Article,

Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
Croll, S D; Suri, C; Compton, D L; Simmons, M V; Yancopoulos, G D; Lindsay, R M; Wiegand, S J; Rudge, J S; Scharfman, H E
1999 ;93(4):1491-1506, Neuroscience
— id: 73420, year: 1999, vol: 93, page: 1491, stat: Journal Article,

The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy
Scharfman, H E
1999 ;79:805-820, Advances in neurology
— id: 73421, year: 1999, vol: 79, page: 805, stat: Journal Article,

Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus
Scharfman, H E; Goodman, J H; Sollas, A L
1999 Jul 1;19(13):5619-5631, Journal of neuroscience
— id: 73419, year: 1999, vol: 19, page: 5619, stat: Journal Article,

Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices
Scharfman, H E; Hodgkins, P S; Lee, S C; Schwarcz, R
1999 Oct 22;274(2):111-114, Neuroscience letters
— id: 73422, year: 1999, vol: 274, page: 111, stat: Journal Article,

Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro
Scharfman, H E; Goodman, J H
1998 Oct;86(3):751-764, Neuroscience
— id: 73514, year: 1998, vol: 86, page: 751, stat: Journal Article,

Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss
Scharfman, H E; Goodman, J H; Du, F; Schwarcz, R
1998 Dec;80(6):3031-3046, Journal of neurophysiology
— id: 73515, year: 1998, vol: 80, page: 3031, stat: Journal Article,

Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor
Scharfman, H E
1997 Aug;78(2):1082-1095, Journal of neurophysiology
— id: 73513, year: 1997, vol: 78, page: 1082, stat: Journal Article,

Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices
Scharfman, H E; Ofer, A
1997 Mar 14;224(2):115-118, Neuroscience letters
— id: 73511, year: 1997, vol: 224, page: 115, stat: Journal Article,

Positive feedback from hilar mossy cells to granule cells in the dentate gyrus revealed by voltage-sensitive dye and microelectrode recording
Jackson, M B; Scharfman, H E
1996 Jul;76(1):601-616, Journal of neurophysiology
— id: 73509, year: 1996, vol: 76, page: 601, stat: Journal Article,

Conditions required for polysynaptic excitation of dentate granule cells by area CA3 pyramidal cells in rat hippocampal slices
Scharfman, H E
1996 Jun;72(3):655-668, Neuroscience
— id: 73512, year: 1996, vol: 72, page: 655, stat: Journal Article,

Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro
Scharfman, H E
1996 Nov;76(5):2986-3001, Journal of neurophysiology
— id: 73510, year: 1996, vol: 76, page: 2986, stat: Journal Article,

Responses to gamma-aminobutyric acid of rat visual cortical neurons in tissue slices
Scharfman, Helen E
[S.l. : s.n.], 1996,
— id: 1381, year: 1996, vol: , page: , stat: ,

Electrophysiological diversity of pyramidal-shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro
Scharfman, H E
1995 ;5(4):287-305, Hippocampus
— id: 73508, year: 1995, vol: 5, page: 287, stat: Journal Article,

Electrophysiological evidence that dentate hilar mossy cells are excitatory and innervate both granule cells and interneurons
Scharfman, H E
1995 Jul;74(1):179-194, Journal of neurophysiology
— id: 73497, year: 1995, vol: 74, page: 179, stat: Journal Article,

EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices
Scharfman, H E
1994 Oct;14(10):6041-6057, Journal of neuroscience
— id: 73500, year: 1994, vol: 14, page: 6041, stat: Journal Article,

Evidence from simultaneous intracellular recordings in rat hippocampal slices that area CA3 pyramidal cells innervate dentate hilar mossy cells
Scharfman, H E
1994 Nov;72(5):2167-2180, Journal of neurophysiology
— id: 73499, year: 1994, vol: 72, page: 2167, stat: Journal Article,

Paradoxical enhancement by bicuculline of dentate granule cell IPSPs evoked by fimbria stimulation in rat hippocampal slices
Scharfman, H E
1994 Feb 28;168(1-2):29-33, Neuroscience letters
— id: 73502, year: 1994, vol: 168, page: 29, stat: Journal Article,

Synchronization of area CA3 hippocampal pyramidal cells and non-granule cells of the dentate gyrus in bicuculline-treated rat hippocampal slices
Scharfman, H E
1994 Mar;59(2):245-257, Neuroscience
— id: 73501, year: 1994, vol: 59, page: 245, stat: Journal Article,

Electron microscopy of intracellularly labeled neurons in the hippocampal slice preparation
Kunkel, D D; Scharfman, H E; Schmiege, D L; Schwartzkroin, P A
1993 Jan 1;24(1):67-84, Microscopy research & technique
— id: 73498, year: 1993, vol: 24, page: 67, stat: Journal Article,

Activation of dentate hilar neurons by stimulation of the fimbria in rat hippocampal slices
Scharfman, H E
1993 Jun 25;156(1-2):61-66, Neuroscience letters
— id: 73504, year: 1993, vol: 156, page: 61, stat: Journal Article,

Characteristics of spontaneous and evoked EPSPs recorded from dentate spiny hilar cells in rat hippocampal slices
Scharfman, H E
1993 Aug;70(2):742-757, Journal of neurophysiology
— id: 73503, year: 1993, vol: 70, page: 742, stat: Journal Article,

Spiny neurons of area CA3c in rat hippocampal slices have similar electrophysiological characteristics and synaptic responses despite morphological variation
Scharfman, H E
1993 Jan;3(1):9-28, Hippocampus
— id: 73506, year: 1993, vol: 3, page: 9, stat: Journal Article,

Blockade of excitation reveals inhibition of dentate spiny hilar neurons recorded in rat hippocampal slices
Scharfman, H E
1992 Sep;68(3):978-984, Journal of neurophysiology
— id: 73436, year: 1992, vol: 68, page: 978, stat: Journal Article,

Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny 'fast-spiking' cells
Scharfman, H E
1992 ;7:93-109, Epilepsy research. Supplement
— id: 73437, year: 1992, vol: 7, page: 93, stat: Journal Article,

Dentate hilar cells with dendrites in the molecular layer have lower thresholds for synaptic activation by perforant path than granule cells
Scharfman, H E
1991 Jun;11(6):1660-1673, Journal of neuroscience
— id: 73479, year: 1991, vol: 11, page: 1660, stat: Journal Article,

Comparisons of neocortex and hippocampus
Scharfman, H E
1990 Sep;13(9):365-366, Trends in neurosciences
— id: 73466, year: 1990, vol: 13, page: 365, stat: Journal Article,

Synaptic connections of dentate granule cells and hilar neurons: results of paired intracellular recordings and intracellular horseradish peroxidase injections
Scharfman, H E; Kunkel, D D; Schwartzkroin, P A
1990 ;37(3):693-707, Neuroscience
— id: 73480, year: 1990, vol: 37, page: 693, stat: Journal Article,

N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices
Scharfman, H E; Lu, S M; Guido, W; Adams, P R; Sherman, S M
1990 Jun;87(12):4548-4552, Proceedings of the National Academy of Sciences of the United States of America
— id: 73477, year: 1990, vol: 87, page: 4548, stat: Journal Article,

Consequences of prolonged afferent stimulation of the rat fascia dentata: epileptiform activity in area CA3 of hippocampus
Scharfman, H E; Schwartzkroin, P A
1990 ;35(3):505-517, Neuroscience
— id: 73482, year: 1990, vol: 35, page: 505, stat: Journal Article,

Responses of cells of the rat fascia dentata to prolonged stimulation of the perforant path: sensitivity of hilar cells and changes in granule cell excitability
Scharfman, H E; Schwartzkroin, P A
1990 ;35(3):491-504, Neuroscience
— id: 73481, year: 1990, vol: 35, page: 491, stat: Journal Article,

Similarities in circuitry between Ammon's horn and dentate gyrus: local interactions and parallel processing
Schwartzkroin, P A; Scharfman, H E; Sloviter, R S
1990 ;83:269-286, Progress in brain research
— id: 73478, year: 1990, vol: 83, page: 269, stat: Journal Article,

Intracellular dyes mask immunoreactivity of hippocampal interneurons
Scharfman, H E; Kunkel, D D; Schwartzkroin, P A
1989 Jan 2;96(1):23-28, Neuroscience letters
— id: 73489, year: 1989, vol: 96, page: 23, stat: Journal Article,

Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation
Scharfman, H E; Schwartzkroin, P A
1989 Oct 13;246(4927):257-260, Science
— id: 73484, year: 1989, vol: 246, page: 257, stat: Journal Article,

Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices
Scharfman, H E; Schwartzkroin, P A
1989 Jul 31;493(2):205-211, Brain research
— id: 73486, year: 1989, vol: 493, page: 205, stat: Journal Article,

Physiological correlates of responses to gamma-aminobutyric acid (GABA) recorded from rat visual cortical neurons in vitro
Scharfman, H E; Sarvey, J M
1988 ;2(6):619-626, Synapse
— id: 73492, year: 1988, vol: 2, page: 619, stat: Journal Article,

Electrophysiology of morphologically identified mossy cells of the dentate hilus recorded in guinea pig hippocampal slices
Scharfman, H E; Schwartzkroin, P A
1988 Oct;8(10):3812-3821, Journal of neuroscience
— id: 73483, year: 1988, vol: 8, page: 3812, stat: Journal Article,

Further studies of the effects of somatostatin and related peptides in area CA1 of rabbit hippocampus
Scharfman, H E; Schwartzkroin, P A
1988 Dec;8(4):411-429, Cellular & molecular neurobiology
— id: 73487, year: 1988, vol: 8, page: 411, stat: Journal Article,

Responses to GABA recorded from identified rat visual cortical neurons
Scharfman, H E; Sarvey, J M
1987 Nov;23(2):407-422, Neuroscience
— id: 73493, year: 1987, vol: 23, page: 407, stat: Journal Article,

gamma-Aminobutyrate sensitivity does not change during long-term potentiation in rat hippocampal slices
Scharfman, H E; Sarvey, J M
1985 Jul;15(3):695-702, Neuroscience
— id: 73491, year: 1985, vol: 15, page: 695, stat: Journal Article,

Postsynaptic firing during repetitive stimulation is required for long-term potentiation in hippocampus
Scharfman, H E; Sarvey, J M
1985 Apr 8;331(2):267-274, Brain research
— id: 73490, year: 1985, vol: 331, page: 267, stat: Journal Article,

Responses to gamma-aminobutyric acid applied to cell bodies and dendrites of rat visual cortical neurons
Scharfman, H E; Sarvey, J M
1985 Dec 9;358(1-2):385-389, Brain research
— id: 73494, year: 1985, vol: 358, page: 385, stat: Journal Article,