Helen E. Scharfman

Biosketch / Results /

Helen E. Scharfman, Ph.D.

Professor;
Departments of Child and Adolescent Psychiatry (Hoagwood Rsch), Neuroscience and Physiology (Neuro/Phys) and Psychiatry

Contact Info

Address

Floor 8 Room 8-434.2
1 Park Avenue
, NY

845-398-5427
Helen.Scharfman@nyumc.org

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Education

1977-1981 — Vassar College, Graduate Education
1986 — Uniformed Services Univ, Graduate Education

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age
Duffy, Aine M; Morales-Corraliza, Jose; Bermudez-Hernandez, Keria M; Schaner, Michael J; Magagna-Poveda, Alejandra; Mathews, Paul M; Scharfman, Helen E
2014 Jul;:1-6, Neurobiology of aging
— id: 1141552, year: 2014, vol: , page: 1, stat: Journal Article,

How can we identify ictal and interictal abnormal activity?
Fisher, Robert S; Scharfman, Helen E; deCurtis, Marco
2014 ;813:3-23, Advances in experimental medicine & biology
— id: 1074892, year: 2014, vol: 813, page: 3, stat: Journal Article,

Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce, Patrice S; Friedman, Daniel; Lafrancois, John J; Iyengar, Sloka S; Fenton, Andre A; Maclusky, Neil J; Scharfman, Helen E
2014 Mar;32:121-131, Epilepsy & behavior
— id: 829482, year: 2014, vol: 32, page: 121, stat: Journal Article,

Is plasticity of GABAergic mechanisms relevant to epileptogenesis?
Scharfman, Helen E; Brooks-Kayal, Amy R
2014 ;813:133-150, Advances in experimental medicine & biology
— id: 1074902, year: 2014, vol: 813, page: 133, stat: Journal Article,

Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats
Scharfman, Helen E; Maclusky, Neil J
2014 Jan;76 Pt C:696-708, Neuropharmacology
— id: 680892, year: 2014, vol: 76 Pt C, page: 696, stat: Journal Article,

Sex differences in the neurobiology of epilepsy: A preclinical perspective
Scharfman, Helen E; MacLusky, Neil J
2014 Jul;:1-5, Neurobiology of disease
— id: 1076192, year: 2014, vol: , page: 1, stat: Journal Article,

p75NTR, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
VonDran, Melissa W; LaFrancois, John; Padow, Victoria A; Friedman, Wilma J; Scharfman, Helen E; Milner, Teresa A; Hempstead, Barbara L
2014 ;6(5):?-? e97, ASN neuro
— id: 1299872, year: 2014, vol: 6, page: ?, stat: Journal Article,

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus
Yang, Jianmin; Harte-Hargrove, Lauren C; Siao, Chia-Jen; Marinic, Tina; Clarke, Roshelle; Ma, Qian; Jing, Deqiang; Lafrancois, John J; Bath, Kevin G; Mark, Willie; Ballon, Douglas; Lee, Francis S; Scharfman, Helen E; Hempstead, Barbara L
2014 May;7(3):796-806, Cell reports
— id: 996552, year: 2014, vol: 7, page: 796, stat: Journal Article,

Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research
Bath, Kevin G; Scharfman, Helen E
2013 Mar;26(3):427-439, Epilepsy & behavior
— id: 829842, year: 2013, vol: 26, page: 427, stat: Journal Article,

Behavioral and neuroendocrine assays for studying epilepsy-associated depression Response
Brooks-Kayal, Amy R.; Bath, Kevin G.; Berg, Anne T.; Galanopoulou, Aristea S.; Holmes, Gregory L.; Jensen, Frances E.; Kanner, Andres M.; O'Brien, Terence J.; Whittemore, Vicky H.; Winawer, Melodie R.; Patel, Manisha; Scharfman, Helen E.
2013 DEC;54(12):2229-2230, Epilepsia
— id: 700892, year: 2013, vol: 54, page: 2229, stat: Journal Article,

Authors' response to letter by A. Mazarati
Brooks-Kayal, Amy R; Bath, Kevin G; Berg, Anne T; Galanopoulou, Aristea S; Holmes, Gregory L; Jensen, Frances E; Kanner, Andres M; O'Brien, Terence J; Whittemore, Vicky H; Winawer, Melodie R; Patel, Manisha; Scharfman, Helen E
2013 Dec;54(12):2229-2230, Epilepsia
— id: 829792, year: 2013, vol: 54, page: 2229, stat: Journal Article,

Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy
Brooks-Kayal, Amy R; Bath, Kevin G; Berg, Anne T; Galanopoulou, Aristea S; Holmes, Gregory L; Jensen, Frances E; Kanner, Andres M; O'Brien, Terence J; Whittemore, Vicky H; Winawer, Melodie R; Patel, Manisha; Scharfman, Helen E
2013 Aug;54 Suppl 4:44-60, Epilepsia
— id: 829812, year: 2013, vol: 54 Suppl 4, page: 44, stat: Journal Article,

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms
Chin, Jeannie; Scharfman, Helen E
2013 Mar;26(3):343-351, Epilepsy & behavior
— id: 829832, year: 2013, vol: 26, page: 343, stat: Journal Article,

Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo
Duffy, Aine M; Schaner, Michael J; Chin, Jeannie; Scharfman, Helen E
2013 Aug;23(8):649-655, Hippocampus
— id: 515922, year: 2013, vol: 23, page: 649, stat: Journal Article,

Corrigendum to "Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus" [Neurobiol. Dis. 26/1 (2007) 174-188]
Howell, Owain W; Silva, Sharmalene; Scharfman, Helen E; Sosunov, Alexander A; Zaben, Malik; Shtaya, Anan; Mckhann, Guy 2nd; Herzog, Herbert; Laskowski, Alexandra; Gray, William P
2013 Jan;49:199-199, Neurobiology of disease
— id: 1310182, year: 2013, vol: 49, page: 199, stat: Journal Article,

The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function
Myers, Catherine E; Bermudez-Hernandez, Keria; Scharfman, Helen E
2013 ;8(6):e68208-e68208 e68208, PLoS one
— id: 829822, year: 2013, vol: 8, page: e68208, stat: Journal Article,

Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.)
Scharfman, Helen E
2013 Dec;38(11):3552-3553, European journal of neuroscience
— id: 829802, year: 2013, vol: 38, page: 3552, stat: Journal Article,

Preface to the Special Issue entitled "The Future of Translational Epilepsy Research"
Scharfman, Helen E
2013 Mar;26(3):209-209, Epilepsy & behavior
— id: 242222, year: 2013, vol: 26, page: 209, stat: Journal Article,

Aquaporin-4 water channels and synaptic plasticity in the hippocampus
Scharfman, Helen E; Binder, Devin K
2013 Dec;63(7):702-711, Neurochemistry international
— id: 626702, year: 2013, vol: 63, page: 702, stat: Journal Article,

The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders
Scharfman, Helen E; Chao, Moses V
2013 Sep-Dec;4(3-4):123-135, Cognitive neuroscience
— id: 652262, year: 2013, vol: 4, page: 123, stat: Journal Article,

Testosterone Depletion in Adult Male Rats Increases Mossy Fiber Transmission, LTP, and Sprouting in Area CA3 of Hippocampus
Skucas, Vanessa A; Duffy, Aine M; Harte-Hargrove, Lauren C; Magagna-Poveda, Alejandra; Radman, Thomas; Chakraborty, Goutam; Schroeder, Charles E; Maclusky, Neil J; Scharfman, Helen E
2013 Feb;33(6):2338-2355, Journal of neuroscience
— id: 240802, year: 2013, vol: 33, page: 2338, stat: Journal Article,

Reduced Hippocampal Brain-Derived Neurotrophic Factor (BDNF) in Neonatal Rats after Prenatal Exposure to Propylthiouracil (PTU)
Chakraborty, Goutam; Magagna-Poveda, Alejandra; Parratt, Carolyn; Umans, Jason G; Maclusky, Neil J; Scharfman, Helen E
2012 Mar;153(3):1311-1316, Endocrinology
— id: 160240, year: 2012, vol: 153, page: 1311, stat: Journal Article,

BDNF-estrogen interactions in hippocampal mossy fiber pathway: implications for normal brain function and disease
Harte-Hargrove, Lauren; Maclusky, Neil J; Scharfman, Helen E
2012 Dec;:46-66, Neuroscience
— id: 210432, year: 2012, vol: , page: 46, stat: Journal Article,

Cognitive detection of preclinical Alzheimer's disease
Lau, H; Karantzoulis, S; Myers, C; Pirraglia, E; Li, Y; Gurnani, A; Glodzik, L; Scharfman, H; Kesner, R; De, Leon M; Ferris, S
2012 2012;8(4):P358-P358, Alzheimer's & dementia
— id: 178085, year: 2012, vol: 8, page: P358, stat: Journal Article,

Early cognitive experience prevents adult deficits in a neurodevelopmental schizophrenia model
Lee, Heekyung; Dvorak, Dino; Kao, Hsin-Yi; Duffy, Aine M; Scharfman, Helen E; Fenton, Andre A
2012 Aug;75(4):714-724, Neuron
— id: 182022, year: 2012, vol: 75, page: 714, stat: Journal Article,

Temporal lobe epilepsy and BDNF Receptor, TrkB
McNamara, J.O.; Scharfman, H.E.
Jasper New York : Oxford University Press, 2012,
— id: 210492, year: 2012, vol: , page: ?, stat: Chapter,

Alzheimer's disease and epilepsy: insight from animal models
McNamara, James O.; Scharfman, Helen E.; Scharfman, Helen E
2012 Mar;7(2):177-192, Future neurology
— id: 210452, year: 2012, vol: 7, page: 177, stat: Journal Article,

Introduction to 'steroid hormone actions in the CNS: The role of brain-derived neurotrophic factor (BDNF)'
Scharfman, H E; Kramer, E A; Luine, V; Srivastava, D P
2012 Nov;:1-2, Neuroscience
— id: 210482, year: 2012, vol: , page: 1, stat: Journal Article,

"Untangling" Alzheimer's disease and epilepsy
Scharfman, Helen E
2012 Sep;12(5):178-183, Epilepsy currents
— id: 210442, year: 2012, vol: 12, page: 178, stat: Journal Article,

New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction
Scharfman, Helen E.; Pierce, Joseph P.
2012 JUN;53 1 1(SI):98-108, Epilepsia
— id: 169426, year: 2012, vol: 53 1 1, page: 98, stat: Journal Article,

Hilar mossy cells of the dentate gyrus: a historical perspective
Scharfman, Helen E; Myers, Catherine E
2012 ;6:106-106, Frontiers in neural circuits
— id: 223272, year: 2012, vol: 6, page: 106, stat: Journal Article,

New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction
Scharfman, Helen E; Pierce, Joseph P
2012 Jun;53 Suppl 1:109-115, Epilepsia
— id: 167509, year: 2012, vol: 53 Suppl 1, page: 109, stat: Journal Article,

Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design
Simonato, Michele; Loscher, Wolfgang; Cole, Andrew J; Dudek, F Edward; Engel, Jerome Jr; Kaminski, Rafal M; Loeb, Jeffrey A; Scharfman, Helen; Staley, Kevin J; Velisek, Libor; Klitgaard, Henrik
2012 Nov;53(11):1860-1867, Epilepsia
— id: 214682, year: 2012, vol: 53, page: 1860, stat: Journal Article,

17beta-estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus
Barouk, Sharon; Hintz, Tana; Li, Ping; Duffy, Aine M; MacLusky, Neil J; Scharfman, Helen E
2011 May;152(5):1745-1751, Endocrinology
— id: 134250, year: 2011, vol: 152, page: 1745, stat: Journal Article,

A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons
Duffy, Aine M; Schaner, Michael J; Wu, Synphen H; Staniszewski, Agnieszka; Kumar, Asok; Arevalo, Juan Carlos; Arancio, Ottavio; Chao, Moses V; Scharfman, Helen E
2011 Jun;229(2):409-420, Experimental neurology
— id: 145797, year: 2011, vol: 229, page: 409, stat: Journal Article,

Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures
McCloskey, Daniel P; Scharfman, Helen E
2011 Nov;97(1-2):92-102, Epilepsy research
— id: 210462, year: 2011, vol: 97, page: 92, stat: Journal Article,

Pattern separation in the dentate gyrus: A role for the CA3 backprojection
Myers CE; Scharfman HE
2011 Nov;21(11):1190-1215, Hippocampus
— id: 138349, year: 2011, vol: 21, page: 1190, stat: Journal Article,

Morphometry of hilar ectopic granule cells in the rat
Pierce, Joseph P; McCloskey, Daniel P; Scharfman, Helen E
2011 Apr 15;519(6):1196-1218, Journal of comparative neurology
— id: 134213, year: 2011, vol: 519, page: 1196, stat: Journal Article,

Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4
Skucas VA; Mathews IB; Yang J; Cheng Q; Treister A; Duffy AM; Verkman AS; Hempstead BL; Wood MA; Binder DK; Scharfman HE
2011 Apr 27;31(17):6392-6397, Journal of neuroscience
— id: 134260, year: 2011, vol: 31, page: 6392, stat: Journal Article,

Protective role of aquaporin-4 water channels after contusion spinal cord injury
Kimura, Atsushi; Hsu, Mike; Seldin, Marcus; Verkman, Alan S; Scharfman, Helen E; Binder, Devin K
2010 Jun;67(6):794-801, Annals of neurology
— id: 114777, year: 2010, vol: 67, page: 794, stat: Journal Article,

Seizing an opportunity: broader definitions of epilepsy may lead to better treatments
Scharfman, Helen E
2010 Sep;2010:18-18, Cerebrum : the Dana forum on brain science
— id: 829852, year: 2010, vol: 2010, page: 18, stat: Journal Article,

Seizing an Opportunity: Broader Definitions of Epilepsy May Lead to Better Treatments
Scharfman, Helen E
2010 Sep;2010:651-661, Cerebrum : the Dana forum on brain science
— id: 1065082, year: 2010, vol: 2010, page: 651, stat: Journal Article,

Dynamics of Active Sensing and perceptual selection
Schroeder, Charles E; Wilson, Donald A; Radman, Thomas; Scharfman, Helen; Lakatos, Peter
2010 Apr;20(2):172-176, Current opinion in neurobiology
— id: 114778, year: 2010, vol: 20, page: 172, stat: Journal Article,

A role for hilar cells in pattern separation in the dentate gyrus: A computational approach
Myers, Catherine E; Scharfman, Helen E
2009 Apr;19(4):321-337, Hippocampus
— id: 94640, year: 2009, vol: 19, page: 321, stat: Journal Article,

A Rat Model of Epilepsy in Women: a Tool to Study Physiological Interactions Between Endocrine Systems and Seizures
Scharfman, Helen E; Malthankar-Phatak, Gauri H; Friedman, Daniel; Pearce, Patrice; McCloskey, Daniel P; Harden, Cynthia L; Maclusky, Neil J
2009 Sep;150(9):4437-4442, Endocrinology
— id: 100035, year: 2009, vol: 150, page: 4437, stat: Journal Article,

Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy
Scharfman, Helen E; McCloskey, Daniel P
2009 Aug;85(2-3):150-161, Epilepsy research
— id: 108180, year: 2009, vol: 85, page: 150, stat: Journal Article,

THE SPATIAL RELATIONSHIP OF HIPPOCAMPAL INTERICTAL DISCHARGES AND HIGH FREQUENCY OSCILLATIONS IN VIVO IN A RAT MODEL OF TEMPORAL LOBE EPILEPSY
Friedman, D; Schevon, CA; Emerson, RG; Scharfman, H
2008 DEC ;49(12):170-170, Epilepsia
— id: 91392, year: 2008, vol: 49, page: 170, stat: Journal Article,

Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)
Macbeth, Abbe H; Scharfman, Helen E; Maclusky, Neil J; Gautreaux, Claris; Luine, Victoria N
2008 Jun;54(1):7-17, Hormones & behavior
— id: 76101, year: 2008, vol: 54, page: 7, stat: Journal Article,

Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effects
McCloskey, Daniel P; Hintz, Tana M; Scharfman, Helen E
2008 May 15;76(1-2):36-44, Brain research bulletin
— id: 94641, year: 2008, vol: 76, page: 36, stat: Journal Article,

Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus
Nicoletti, J N; Shah, S K; McCloskey, D P; Goodman, J H; Elkady, A; Atassi, H; Hylton, D; Rudge, J S; Scharfman, H E; Croll, S D
2008 Jan 2;151(1):232-241, Neuroscience
— id: 76099, year: 2008, vol: 151, page: 232, stat: Journal Article,

Estrogen-growth factor interactions and their contributions to neurological disorders
Scharfman, Helen E; MacLusky, Neil J
2008 Jul;48 Suppl 2:S77-S89, Headache
— id: 93351, year: 2008, vol: 48 Suppl 2, page: S77, stat: Journal Article,

Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus
Howell, Owain W; Silva, Sharmalene; Scharfman, Helen E; Sosunov, Alexander A; Zaben, Malik; Shatya, Anan; McKhann, Guy 2nd; Herzog, Herbert; Laskowski, Alexandra; Gray, William P
2007 Apr;26(1):174-188, Neurobiology of disease
— id: 73471, year: 2007, vol: 26, page: 174, stat: Journal Article,

Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures
Pierce, Joseph P; Punsoni, Michael; McCloskey, Daniel P; Scharfman, Helen E
2007 Jul 11;422(2):136-140, Neuroscience letters
— id: 73474, year: 2007, vol: 422, page: 136, stat: Journal Article,

The dentate gyrus : a comprehensive guide to structure function and clinical implications
Scharfman, Helen E
Amsterdam : Elsevier, 2007,
— id: 1379, year: 2007, vol: , page: , stat: ,

The CA3 "backprojection" to the dentate gyrus
Scharfman, Helen E
2007 ;163:627-637, Progress in brain research
— id: 76103, year: 2007, vol: 163, page: 627, stat: Journal Article,

The neurobiology of epilepsy
Scharfman, Helen E
2007 Jul;7(4):348-354, Current neurology & neuroscience reports
— id: 73476, year: 2007, vol: 7, page: 348, stat: Journal Article,

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy
Scharfman, Helen E; Gray, William P
2007 ;48 Suppl 2:33-41, Epilepsia
— id: 73473, year: 2007, vol: 48 Suppl 2, page: 33, stat: Journal Article,

Neuroscience. Is more neurogenesis always better?
Scharfman, Helen E; Hen, Rene
2007 Jan 19;315(5810):336-338, Science
— id: 73470, year: 2007, vol: 315, page: 336, stat: Journal Article,

Changes in hippocampal function of ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surge
Scharfman, Helen E; Hintz, Tana M; Gomez, Juan; Stormes, Kerry A; Barouk, Sharon; Malthankar-Phatak, Gauri H; McCloskey, Daniel P; Luine, Victoria N; Maclusky, Neil J
2007 Nov;26(9):2595-2612, European journal of neuroscience
— id: 76100, year: 2007, vol: 26, page: 2595, stat: Journal Article,

Ectopic granule cells of the rat dentate gyrus
Scharfman, Helen; Goodman, Jeffrey; McCloskey, Daniel
2007 ;29(1-2):14-27, Developmental neuroscience
— id: 73469, year: 2007, vol: 29, page: 14, stat: Journal Article,

Acute and chronic changes in glycogen phosphorylase in hippocampus and entorhinal cortex after status epilepticus in the adult male rat
Walling, Susan G; Rigoulot, Marie-Aude; Scharfman, Helen E
2007 Jul;26(1):178-189, European journal of neuroscience
— id: 73475, year: 2007, vol: 26, page: 178, stat: Journal Article,

Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice
Winawer, M R; Makarenko, N; McCloskey, D P; Hintz, T M; Nair, N; Palmer, A A; Scharfman, H E
2007 Oct 26;149(2):465-475, Neuroscience
— id: 76102, year: 2007, vol: 149, page: 465, stat: Journal Article,

Molecular mechanisms of dentate gyrus granule cell resistance to seizure-induced damage
Wu, SH; Arevalo, JC; Malthankar-Phatak, GH; Hintz, TM; McCloskey, DP; Tessarollo, L; Chao, MV; Scharfman, HE
2007 OCT ;48(1):241-241, Epilepsia
— id: 87154, year: 2007, vol: 48, page: 241, stat: Journal Article,

Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat
McCloskey, Daniel P; Hintz, Tana M; Pierce, Joseph P; Scharfman, Helen E
2006 Oct;24(8):2203-2210, European journal of neuroscience
— id: 73467, year: 2006, vol: 24, page: 2203, stat: Journal Article,

Preface
Scharfman H
2006 Dec;27(4):361-362, Frontiers in neuroendocrinology
— id: 73472, year: 2006, vol: 27, page: 361, stat: Journal Article,

Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis
Scharfman, Helen E; Gray, William P
2006 ;(95):193-211, EXS
— id: 73464, year: 2006, vol: , page: 193, stat: Journal Article,

The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female
Scharfman, Helen E; MacLusky, Neil J
2006 Sep;47(9):1423-1440, Epilepsia
— id: 73465, year: 2006, vol: 47, page: 1423, stat: Journal Article,

Growth factors and epilepsy
Binder, Devin K; Scharfman, Helen E
New York : Nova Science, 2005,
— id: 1380, year: 2005, vol: , page: , stat: ,

Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus
Howell, Owain W; Doyle, Kharen; Goodman, Jeffrey H; Scharfman, Helen E; Herzog, Herbert; Pringle, Ashley; Beck-Sickinger, Annette G; Gray, William P
2005 May;93(3):560-570, Journal of neurochemistry
— id: 73454, year: 2005, vol: 93, page: 560, stat: Journal Article,

Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures
McCloskey, Daniel P; Croll, Susan D; Scharfman, Helen E
2005 Sep 28;25(39):8889-8897, Journal of neuroscience
— id: 73460, year: 2005, vol: 25, page: 8889, stat: Journal Article,

Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures
Pierce, Joseph P; Melton, Jay; Punsoni, Michael; McCloskey, Daniel P; Scharfman, Helen E
2005 Dec;196(2):316-331, Experimental neurology
— id: 73463, year: 2005, vol: 196, page: 316, stat: Journal Article,

Brain-derived Neurotrophic Factor and Epilepsy-A Missing Link?
Scharfman, Helen E
2005 May-Jun;5(3):83-88, Epilepsy currents
— id: 73458, year: 2005, vol: 5, page: 83, stat: Journal Article,

The Absence of Information about Hormones and Absence
Scharfman, Helen E
2005 May-Jun;5(3):101-103, Epilepsy currents
— id: 73459, year: 2005, vol: 5, page: 101, stat: Journal Article,

Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine
Scharfman, Helen E; Goodman, Jeffrey H; Rigoulot, Marie-Aude; Berger, Russell E; Walling, Susan G; Mercurio, Thomas C; Stormes, Kerry; Maclusky, Neil J
2005 Nov;196(1):73-86, Experimental neurology
— id: 73457, year: 2005, vol: 196, page: 73, stat: Journal Article,

Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue?
Scharfman, Helen E; Maclusky, Neil J
2005 Feb;28(2):79-85, Trends in neurosciences
— id: 73452, year: 2005, vol: 28, page: 79, stat: Journal Article,

Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
Scharfman, Helen; Goodman, Jeffrey; Macleod, Adam; Phani, Sudar; Antonelli, Cara; Croll, Susan
2005 Apr;192(2):348-356, Experimental neurology
— id: 73453, year: 2005, vol: 192, page: 348, stat: Journal Article,

A woman's prerogative
Staley, Kevin; Scharfman, Helen
2005 Jun;8(6):697-699, Nature neuroscience
— id: 73455, year: 2005, vol: 8, page: 697, stat: Journal Article,

Synaptic plasticity and transsynaptic signaling
Stanton, Patric K; Bramham, Clive; Scharfman, Helen E
New York : Springer, 2005,
— id: 1378, year: 2005, vol: , page: , stat: ,

Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats
Wu, Hui-Qiu; Rassoulpour, Arash; Goodman, Jeffrey H; Scharfman, Helen E; Bertram, Edward H; Schwarcz, Robert
2005 Jul;46(7):1010-1016, Epilepsia
— id: 73456, year: 2005, vol: 46, page: 1010, stat: Journal Article,

Recent advances in epilepsy research
Binder, Devin K; Scharfman, Helen E
New York : Kluwer Academic, 2004,
— id: 1376, year: 2004, vol: , page: , stat: ,

Brain-derived neurotrophic factor
Binder, Devin K; Scharfman, Helen E
2004 Sep;22(3):123-131, Growth factors
— id: 73451, year: 2004, vol: 22, page: 123, stat: Journal Article,

Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword
Croll, Susan D; Goodman, Jeffrey H; Scharfman, Helen E
2004 ;548:57-68, Advances in experimental medicine & biology
— id: 73441, year: 2004, vol: 548, page: 57, stat: Journal Article,

Functional implications of seizure-induced neurogenesis
Scharfman, Helen E
2004 ;548:192-212, Advances in experimental medicine & biology
— id: 73442, year: 2004, vol: 548, page: 192, stat: Journal Article,

Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells
Howell, Owain W; Scharfman, Helen E; Herzog, Herbert; Sundstrom, Lars E; Beck-Sickinger, Annette; Gray, William P
2003 Aug;86(3):646-659, Journal of neurochemistry
— id: 73435, year: 2003, vol: 86, page: 646, stat: Journal Article,

Insight into Molecular Mechanisms of Catamenial Epilepsy
Scharfman HE
2003 May;3(3):86-88, Epilepsy currents
— id: 73443, year: 2003, vol: 3, page: 86, stat: Journal Article,

Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures
Scharfman, H E; Sollas, A E; Berger, R E; Goodman, J H; Pierce, J P
2003 ;121(4):1017-1029, Neuroscience
— id: 73439, year: 2003, vol: 121, page: 1017, stat: Journal Article,

Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor
Scharfman, Helen E; Mercurio, Thomas C; Goodman, Jeffrey H; Wilson, Marlene A; MacLusky, Neil J
2003 Dec 17;23(37):11641-11652, Journal of neuroscience
— id: 73440, year: 2003, vol: 23, page: 11641, stat: Journal Article,

Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting
Scharfman, Helen E; Sollas, Anne L; Berger, Russell E; Goodman, Jeffrey H
2003 Oct;90(4):2536-2547, Journal of neurophysiology
— id: 73438, year: 2003, vol: 90, page: 2536, stat: Journal Article,

A Novel Animal Model of Epilepsy Caused by Inhibiting Neuronal Activity during Development
Scharfman H
2002 Jul;2(4):127-128, Epilepsy currents
— id: 73448, year: 2002, vol: 2, page: 127, stat: Journal Article,

Does BDNF Contribute to Temporal Lobe Epilepsy?
Scharfman H
2002 May;2(3):92-94, Epilepsy currents
— id: 73449, year: 2002, vol: 2, page: 92, stat: Journal Article,

Grafts of Encapsulated Fibroblasts Engineered to Release an Anticonvulsant Substance
Scharfman H
2002 Jul;2(4):125-126, Epilepsy currents
— id: 73447, year: 2002, vol: 2, page: 125, stat: Journal Article,

The "Reel" Pathology of Temporal Lobe Epilepsy
Scharfman H
2002 Nov;2(6):196-197, Epilepsy currents
— id: 73444, year: 2002, vol: 2, page: 196, stat: Journal Article,

Upregulation of Multidrug Resistance Transporters in the Epileptic Brain
Scharfman H
2002 Nov;2(6):200-202, Epilepsy currents
— id: 73445, year: 2002, vol: 2, page: 200, stat: Journal Article,

Does the Development of a GABAergic Phenotype by Hippocampal Dentate Gyrus Granule Cells Contribute to Epileptogenesis
Scharfman HE
2002 Mar;2(2):63-63, Epilepsy currents
— id: 73450, year: 2002, vol: 2, page: 63, stat: Journal Article,

Keeping Pace with Pacemaker Channels
Scharfman HE
2002 Sep;2(5):155-156, Epilepsy currents
— id: 73446, year: 2002, vol: 2, page: 155, stat: Journal Article,

Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus
Scharfman, H E; Sollas, A L; Goodman, J H
2002 ;111(1):71-81, Neuroscience
— id: 73432, year: 2002, vol: 111, page: 71, stat: Journal Article,

Epilepsy as an example of neural plasticity
Scharfman, Helen E
2002 Apr;8(2):154-173, Neuroscientist
— id: 73431, year: 2002, vol: 8, page: 154, stat: Journal Article,

Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor
Scharfman, Helen E; Goodman, Jeffrey H; Sollas, Anne L; Croll, Susan D
2002 Apr;174(2):201-214, Experimental neurology
— id: 73430, year: 2002, vol: 174, page: 201, stat: Journal Article,

Structural and functional asymmetry in the normal and epileptic rat dentate gyrus
Scharfman, Helen E; Sollas, Anne L; Smith, Karen L; Jackson, Meyer B; Goodman, Jeffrey H
2002 Dec 23;454(4):424-439, Journal of comparative neurology
— id: 73434, year: 2002, vol: 454, page: 424, stat: Journal Article,

L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat
Wu, Hui-Qui; Lee, Song-Chu; Scharfman, Helen E; Schwarcz, Robert
2002 Sep;177(1):222-232, Experimental neurology
— id: 73433, year: 2002, vol: 177, page: 222, stat: Journal Article,

BDNF and epilepsy: too much of a good thing?
Binder, D K; Croll, S D; Gall, C M; Scharfman, H E
2001 Jan;24(1):47-53, Trends in neurosciences
— id: 73428, year: 2001, vol: 24, page: 47, stat: Journal Article,

Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells
Scharfman, H E; Smith, K L; Goodman, J H; Sollas, A L
2001 ;104(3):741-759, Neuroscience
— id: 73429, year: 2001, vol: 104, page: 741, stat: Journal Article,

Epileptogenesis in the parahippocampal region. Parallels with the dentate gyrus
Scharfman, H E
2000 Jun;911:305-327, Annals of the New York Academy of Sciences
— id: 73425, year: 2000, vol: 911, page: 305, stat: Journal Article,

Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro
Scharfman, H E; Goodman, J H; Schwarcz, R
2000 ;19(1):283-297, Amino acids
— id: 73427, year: 2000, vol: 19, page: 283, stat: Journal Article,

Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
Scharfman, H E; Goodman, J H; Sollas, A L
2000 Aug 15;20(16):6144-6158, Journal of neuroscience
— id: 73426, year: 2000, vol: 20, page: 6144, stat: Journal Article,

The parahippocampal region. Implications for neurological and psychiatric diseases. Introduction
Scharfman, H E; Witter, M P; Schwarcz, R
2000 Jun;911:ix-xiii, Annals of the New York Academy of Sciences
— id: 73424, year: 2000, vol: 911, page: ix, stat: Journal Article,

Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo
Wu, H Q; Guidetti, P; Goodman, J H; Varasi, M; Ceresoli-Borroni, G; Speciale, C; Scharfman, H E; Schwarcz, R
2000 ;97(2):243-251, Neuroscience
— id: 73423, year: 2000, vol: 97, page: 243, stat: Journal Article,

Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
Croll, S D; Suri, C; Compton, D L; Simmons, M V; Yancopoulos, G D; Lindsay, R M; Wiegand, S J; Rudge, J S; Scharfman, H E
1999 ;93(4):1491-1506, Neuroscience
— id: 73420, year: 1999, vol: 93, page: 1491, stat: Journal Article,

The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy
Scharfman, H E
1999 ;79:805-820, Advances in neurology
— id: 73421, year: 1999, vol: 79, page: 805, stat: Journal Article,

Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus
Scharfman, H E; Goodman, J H; Sollas, A L
1999 Jul 1;19(13):5619-5631, Journal of neuroscience
— id: 73419, year: 1999, vol: 19, page: 5619, stat: Journal Article,

Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices
Scharfman, H E; Hodgkins, P S; Lee, S C; Schwarcz, R
1999 Oct 22;274(2):111-114, Neuroscience letters
— id: 73422, year: 1999, vol: 274, page: 111, stat: Journal Article,

Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro
Scharfman, H E; Goodman, J H
1998 Oct;86(3):751-764, Neuroscience
— id: 73514, year: 1998, vol: 86, page: 751, stat: Journal Article,

Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss
Scharfman, H E; Goodman, J H; Du, F; Schwarcz, R
1998 Dec;80(6):3031-3046, Journal of neurophysiology
— id: 73515, year: 1998, vol: 80, page: 3031, stat: Journal Article,

Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor
Scharfman, H E
1997 Aug;78(2):1082-1095, Journal of neurophysiology
— id: 73513, year: 1997, vol: 78, page: 1082, stat: Journal Article,

Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices
Scharfman, H E; Ofer, A
1997 Mar 14;224(2):115-118, Neuroscience letters
— id: 73511, year: 1997, vol: 224, page: 115, stat: Journal Article,

Positive feedback from hilar mossy cells to granule cells in the dentate gyrus revealed by voltage-sensitive dye and microelectrode recording
Jackson, M B; Scharfman, H E
1996 Jul;76(1):601-616, Journal of neurophysiology
— id: 73509, year: 1996, vol: 76, page: 601, stat: Journal Article,

Conditions required for polysynaptic excitation of dentate granule cells by area CA3 pyramidal cells in rat hippocampal slices
Scharfman, H E
1996 Jun;72(3):655-668, Neuroscience
— id: 73512, year: 1996, vol: 72, page: 655, stat: Journal Article,

Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro
Scharfman, H E
1996 Nov;76(5):2986-3001, Journal of neurophysiology
— id: 73510, year: 1996, vol: 76, page: 2986, stat: Journal Article,

Responses to gamma-aminobutyric acid of rat visual cortical neurons in tissue slices
Scharfman, Helen E
[S.l. : s.n.], 1996,
— id: 1381, year: 1996, vol: , page: , stat: ,

Electrophysiological diversity of pyramidal-shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro
Scharfman, H E
1995 ;5(4):287-305, Hippocampus
— id: 73508, year: 1995, vol: 5, page: 287, stat: Journal Article,

Electrophysiological evidence that dentate hilar mossy cells are excitatory and innervate both granule cells and interneurons
Scharfman, H E
1995 Jul;74(1):179-194, Journal of neurophysiology
— id: 73497, year: 1995, vol: 74, page: 179, stat: Journal Article,

EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices
Scharfman, H E
1994 Oct;14(10):6041-6057, Journal of neuroscience
— id: 73500, year: 1994, vol: 14, page: 6041, stat: Journal Article,

Evidence from simultaneous intracellular recordings in rat hippocampal slices that area CA3 pyramidal cells innervate dentate hilar mossy cells
Scharfman, H E
1994 Nov;72(5):2167-2180, Journal of neurophysiology
— id: 73499, year: 1994, vol: 72, page: 2167, stat: Journal Article,

Paradoxical enhancement by bicuculline of dentate granule cell IPSPs evoked by fimbria stimulation in rat hippocampal slices
Scharfman, H E
1994 Feb 28;168(1-2):29-33, Neuroscience letters
— id: 73502, year: 1994, vol: 168, page: 29, stat: Journal Article,

Synchronization of area CA3 hippocampal pyramidal cells and non-granule cells of the dentate gyrus in bicuculline-treated rat hippocampal slices
Scharfman, H E
1994 Mar;59(2):245-257, Neuroscience
— id: 73501, year: 1994, vol: 59, page: 245, stat: Journal Article,

Electron microscopy of intracellularly labeled neurons in the hippocampal slice preparation
Kunkel, D D; Scharfman, H E; Schmiege, D L; Schwartzkroin, P A
1993 Jan 1;24(1):67-84, Microscopy research & technique
— id: 73498, year: 1993, vol: 24, page: 67, stat: Journal Article,

Activation of dentate hilar neurons by stimulation of the fimbria in rat hippocampal slices
Scharfman, H E
1993 Jun 25;156(1-2):61-66, Neuroscience letters
— id: 73504, year: 1993, vol: 156, page: 61, stat: Journal Article,

Characteristics of spontaneous and evoked EPSPs recorded from dentate spiny hilar cells in rat hippocampal slices
Scharfman, H E
1993 Aug;70(2):742-757, Journal of neurophysiology
— id: 73503, year: 1993, vol: 70, page: 742, stat: Journal Article,

Spiny neurons of area CA3c in rat hippocampal slices have similar electrophysiological characteristics and synaptic responses despite morphological variation
Scharfman, H E
1993 Jan;3(1):9-28, Hippocampus
— id: 73506, year: 1993, vol: 3, page: 9, stat: Journal Article,

Blockade of excitation reveals inhibition of dentate spiny hilar neurons recorded in rat hippocampal slices
Scharfman, H E
1992 Sep;68(3):978-984, Journal of neurophysiology
— id: 73436, year: 1992, vol: 68, page: 978, stat: Journal Article,

Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny 'fast-spiking' cells
Scharfman, H E
1992 ;7:93-109, Epilepsy research. Supplement
— id: 73437, year: 1992, vol: 7, page: 93, stat: Journal Article,

Dentate hilar cells with dendrites in the molecular layer have lower thresholds for synaptic activation by perforant path than granule cells
Scharfman, H E
1991 Jun;11(6):1660-1673, Journal of neuroscience
— id: 73479, year: 1991, vol: 11, page: 1660, stat: Journal Article,

Comparisons of neocortex and hippocampus
Scharfman, H E
1990 Sep;13(9):365-366, Trends in neurosciences
— id: 73466, year: 1990, vol: 13, page: 365, stat: Journal Article,

Synaptic connections of dentate granule cells and hilar neurons: results of paired intracellular recordings and intracellular horseradish peroxidase injections
Scharfman, H E; Kunkel, D D; Schwartzkroin, P A
1990 ;37(3):693-707, Neuroscience
— id: 73480, year: 1990, vol: 37, page: 693, stat: Journal Article,

N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices
Scharfman, H E; Lu, S M; Guido, W; Adams, P R; Sherman, S M
1990 Jun;87(12):4548-4552, Proceedings of the National Academy of Sciences of the United States of America
— id: 73477, year: 1990, vol: 87, page: 4548, stat: Journal Article,

Consequences of prolonged afferent stimulation of the rat fascia dentata: epileptiform activity in area CA3 of hippocampus
Scharfman, H E; Schwartzkroin, P A
1990 ;35(3):505-517, Neuroscience
— id: 73482, year: 1990, vol: 35, page: 505, stat: Journal Article,

Responses of cells of the rat fascia dentata to prolonged stimulation of the perforant path: sensitivity of hilar cells and changes in granule cell excitability
Scharfman, H E; Schwartzkroin, P A
1990 ;35(3):491-504, Neuroscience
— id: 73481, year: 1990, vol: 35, page: 491, stat: Journal Article,

Similarities in circuitry between Ammon's horn and dentate gyrus: local interactions and parallel processing
Schwartzkroin, P A; Scharfman, H E; Sloviter, R S
1990 ;83:269-286, Progress in brain research
— id: 73478, year: 1990, vol: 83, page: 269, stat: Journal Article,

Intracellular dyes mask immunoreactivity of hippocampal interneurons
Scharfman, H E; Kunkel, D D; Schwartzkroin, P A
1989 Jan 2;96(1):23-28, Neuroscience letters
— id: 73489, year: 1989, vol: 96, page: 23, stat: Journal Article,

Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation
Scharfman, H E; Schwartzkroin, P A
1989 Oct 13;246(4927):257-260, Science
— id: 73484, year: 1989, vol: 246, page: 257, stat: Journal Article,

Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices
Scharfman, H E; Schwartzkroin, P A
1989 Jul 31;493(2):205-211, Brain research
— id: 73486, year: 1989, vol: 493, page: 205, stat: Journal Article,

Physiological correlates of responses to gamma-aminobutyric acid (GABA) recorded from rat visual cortical neurons in vitro
Scharfman, H E; Sarvey, J M
1988 ;2(6):619-626, Synapse
— id: 73492, year: 1988, vol: 2, page: 619, stat: Journal Article,

Electrophysiology of morphologically identified mossy cells of the dentate hilus recorded in guinea pig hippocampal slices
Scharfman, H E; Schwartzkroin, P A
1988 Oct;8(10):3812-3821, Journal of neuroscience
— id: 73483, year: 1988, vol: 8, page: 3812, stat: Journal Article,

Further studies of the effects of somatostatin and related peptides in area CA1 of rabbit hippocampus
Scharfman, H E; Schwartzkroin, P A
1988 Dec;8(4):411-429, Cellular & molecular neurobiology
— id: 73487, year: 1988, vol: 8, page: 411, stat: Journal Article,

Responses to GABA recorded from identified rat visual cortical neurons
Scharfman, H E; Sarvey, J M
1987 Nov;23(2):407-422, Neuroscience
— id: 73493, year: 1987, vol: 23, page: 407, stat: Journal Article,

gamma-Aminobutyrate sensitivity does not change during long-term potentiation in rat hippocampal slices
Scharfman, H E; Sarvey, J M
1985 Jul;15(3):695-702, Neuroscience
— id: 73491, year: 1985, vol: 15, page: 695, stat: Journal Article,

Postsynaptic firing during repetitive stimulation is required for long-term potentiation in hippocampus
Scharfman, H E; Sarvey, J M
1985 Apr 8;331(2):267-274, Brain research
— id: 73490, year: 1985, vol: 331, page: 267, stat: Journal Article,

Responses to gamma-aminobutyric acid applied to cell bodies and dendrites of rat visual cortical neurons
Scharfman, H E; Sarvey, J M
1985 Dec 9;358(1-2):385-389, Brain research
— id: 73494, year: 1985, vol: 358, page: 385, stat: Journal Article,