Herbert H Samuels

Biosketch / Results /

Herbert H Samuels, M.D.

Professor; Helen and Milton A. Kimmelman Professor of Pharmacology; Kimmelman Prof of Pharmacology
Departments of Biochemistry and Molecular Pharmacology and Medicine (Endocrinology Div)

Contact Info

Address
455 First Avenue
Floor 8 Room 835
Public Health Lab
New York, NY 10016

212-263-6279
212-263-6279
Herbert.Samuels@nyumc.org

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Education

— Dr. Samuels was a Research Associate in the lab of Dr. Gordon M. Tomkins' Laboratory of Molecular Biology at the NIAMD until 1970.|, PostDoctoral Training
1965 — NYU School of Medicine, Medical Education
1967 — Dr. Samuels was an Intern and Resident in Medicine at the Albert Einstein College of Medicine completing his training, Residency

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli
Tinnikov, Alexander A; Samuels, Herbert H
2013 ;8(4):e61085-e61085 e61085, PLoS one
— id: 301392, year: 2013, vol: 8, page: e61085, stat: Journal Article,

Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation
Yang, Yawei J; Baltus, Andrew E; Mathew, Rebecca S; Murphy, Elisabeth A; Evrony, Gilad D; Gonzalez, Dilenny M; Wang, Estee P; Marshall-Walker, Christine A; Barry, Brenda J; Murn, Jernej; Tatarakis, Antonis; Mahajan, Muktar A; Samuels, Herbert H; Shi, Yang; Golden, Jeffrey A; Mahajnah, Muhammad; Shenhav, Ruthie; Walsh, Christopher A
2012 Nov;151(5):1097-1112, Cell
— id: 197612, year: 2012, vol: 151, page: 1097, stat: Journal Article,

A Novel Transcription Complex That Selectively Modulates Apoptosis of Breast Cancer Cells through Regulation of FASTKD2
Yeung, Kay T; Das, Sharmistha; Zhang, Jin; Lomniczi, Alejandro; Ojeda, Sergio R; Xu, Chong-Feng; Neubert, Thomas A; Samuels, Herbert H
2011 Jun;31(11):2287-2298, Molecular & cellular biology
— id: 132312, year: 2011, vol: 31, page: 2287, stat: Journal Article,

Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate
Goyanka, Ritu; Das, Sharmistha; Samuels, Herbert H; Cardozo, Timothy
2010 Nov;23(11):809-815, Protein engineering, design & selection : PEDS
— id: 113803, year: 2010, vol: 23, page: 809, stat: Journal Article,

Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor
Vukelic, Sasa; Stojadinovic, Olivera; Pastar, Irena; Vouthounis, Constantinos; Krzyzanowska, Agata; Das, Sharmistha; Samuels, Herbert H; Tomic-Canic, Marjana
2010 Jan 15;285(3):1980-1988, Journal of biological chemistry
— id: 114360, year: 2010, vol: 285, page: 1980, stat: Journal Article,

Identification and characterization of a novel nuclear protein complex Involved In nuclear hormone receptor-mediated gene regulation
Garapaty, Shivani; Xu, Chong-Feng; Trojer, Patrick; Mahajan, Muktar A; Neubert, Thomas A; Samuels, Herbert H
2009 Mar 20;284(12):7542-7552, Journal of biological chemistry
— id: 95312, year: 2009, vol: 284, page: 7542, stat: Journal Article,

Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells
Tinnikov, Alexander A; Yeung, Kay T; Das, Sharmistha; Samuels, Herbert H
2009 Feb 15;69(4):1375-1382, Cancer research
— id: 97576, year: 2009, vol: 69, page: 1375, stat: Journal Article,

Statins, inhibitors of cholesterol synthesis, accelerate wound healing via farnesyl pyrophosphate
Vukelic, S; Stojadinovic, O; Pastar, I; Das, S; Samuels, H; Krzyzanowska, A; Brem, H; Tomic-Canic, M
2009 APR ;129(5):S51-S51, Journal of investigative dermatology
— id: 97875, year: 2009, vol: 129, page: S51, stat: Journal Article,

INHIBITORS OF CHOLESTEROL SYNTHESIS, STATINS, ACCELERATE WOUND HEALING
Vukelic, S; Stojadinovic, O; Pastar, I; Das, S; Samuels, H; Krzyzanowska, A; Ragupathi, M; Brem, H; Tomic-Canic, M
2009 MAR-APR ;17(2):A21-A21, Wound repair & regeneration
— id: 97662, year: 2009, vol: 17, page: A21, stat: Journal Article,

Components of the CCR4-NOT Complex Function as Nuclear Hormone Receptor Coactivators via Association with the NRC-interacting Factor NIF-1
Garapaty, Shivani; Mahajan, Muktar A; Samuels, Herbert H
2008 Mar 14;283(11):6806-6816, Journal of biological chemistry
— id: 76777, year: 2008, vol: 283, page: 6806, stat: Journal Article,

Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development
Mahajan, Muktar A; Samuels, Herbert H
2008 ;6:e002-e002, Nuclear receptor signaling
— id: 76769, year: 2008, vol: 6, page: e002, stat: Journal Article,

The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events
Das, Sharmistha; Nwachukwu, Jerome C; Li, Dangsheng; Vulin, Anthony I; Martinez-Caballero, Sonia; Kinnally, Kathleen W; Samuels, Herbert H
2007 Feb;67(4):1775-1782, Cancer research
— id: 156586, year: 2007, vol: 67, page: 1775, stat: Journal Article,

Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling
Mahajan, Muktar A; Murray, Audrey; Levy, David; Samuels, Herbert H
2007 Aug;21(8):1822-1834, Molecular endocrinology
— id: 73864, year: 2007, vol: 21, page: 1822, stat: Journal Article,

Studies of the bystander effect associated with intrinsic apoptosis
Martinez-Caballero, S; Lue, J; Huang, E; Das, S; Samuels, HH; Kinnally, KW
2007 ;282(6):567A-567A, Biophysical journal
— id: 103312, year: 2007, vol: 282, page: 567A, stat: Journal Article,

Role of PSF-TFE3 oncoprotein in the development of papillary renal cell carcinomas
Mathur, M; Samuels, H H
2007 Jan 11;26(2):277-283, Oncogene
— id: 70300, year: 2007, vol: 26, page: 277, stat: Journal Article,

Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation
Pevsner, Paul H; Naftolin, Frederick; Hillman, Dean E; Miller, Douglas C; Fadiel, Ahmed; Kogus, Alexander; Stern, Arnold; Samuels, Herbert H
2007 ;21(3):429-436, Rapid communications in mass spectrometry
— id: 70734, year: 2007, vol: 21, page: 429, stat: Journal Article,

International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors
Flamant, Frederic; Baxter, John D; Forrest, Douglas; Refetoff, Samuel; Samuels, Herbert; Scanlan, Tom S; Vennstrom, Bjorn; Samarut, Jacques
2006 Dec;58(4):705-711, Pharmacological reviews
— id: 69534, year: 2006, vol: 58, page: 705, stat: Journal Article,

The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain
Tian, Henghe; Mahajan, Muktar A; Wong, Chun Tung; Habeos, Ioanis; Samuels, Herbert H
2006 Sep;20(9):2036-2051, Molecular endocrinology
— id: 68746, year: 2006, vol: 20, page: 2036, stat: Journal Article,

Functional consequences of interactions between thyroid hormone receptors and retinoid X receptor
Li D; Mahajan MA; Samuels HH
2005 ;12(5):356-362, Current opinion in endocrinology & diabetes
— id: 58899, year: 2005, vol: 12, page: 356, stat: Journal Article,

Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth, and development
Mahajan, Muktar A; Samuels, Herbert H
2005 Jun;26(4):583-597, Endocrine reviews
— id: 56108, year: 2005, vol: 26, page: 583, stat: Journal Article,

Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis
Afonja, Olubunmi; Juste, Dominique; Das, Sharmistha; Matsuhashi, Sachiko; Samuels, Herbert H
2004 Oct 21;23(49):8135-8145, Oncogene
— id: 46457, year: 2004, vol: 23, page: 8135, stat: Journal Article,

The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells
Li, Dangsheng; Das, Sharmistha; Yamada, Tatsuya; Samuels, Herbert H
2004 May;24(9):3838-3848, Molecular & cellular biology
— id: 43267, year: 2004, vol: 24, page: 3838, stat: Journal Article,

Novel roles of retinoid X receptor (RXR) and RXR ligand in dynamically modulating the activity of the thyroid hormone receptor/RXR heterodimer
Li, Dangsheng; Yamada, Tatsuya; Wang, Fang; Vulin, A Igor; Samuels, Herbert H
2004 Feb 27;279(9):7427-7437, Journal of biological chemistry
— id: 42149, year: 2004, vol: 279, page: 7427, stat: Journal Article,

The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair
Mahajan, Muktar A; Das, Sharmistha; Zhu, Hong; Tomic-Canic, Marjana; Samuels, Herbert H
2004 Jun;24(11):4994-5004, Molecular & cellular biology
— id: 43266, year: 2004, vol: 24, page: 4994, stat: Journal Article,

PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration
Mathur, Mukul; Das, Sharmistha; Samuels, Herbert H
2003 Aug 7;22(32):5031-5044, Oncogene
— id: 38103, year: 2003, vol: 22, page: 5031, stat: Journal Article,

Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking
Schapira, Matthieu; Raaka, Bruce M; Das, Sharmistha; Fan, Li; Totrov, Maxim; Zhou, Zhiguo; Wilson, Stephen R; Abagyan, Ruben; Samuels, Herbert H
2003 Jun 10;100(12):7354-7359, Proceedings of the National Academy of Sciences of the United States of America
— id: 63078, year: 2003, vol: 100, page: 7354, stat: Journal Article,

RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition
Afonja, Olubunmi; Raaka, Bruce M; Huang, Ambrose; Das, Sharmistha; Zhao, Xinyu; Helmer, Elizabeth; Juste, Dominique; Samuels, Herbert H
2002 Nov 7;21(51):7850-7860, Oncogene
— id: 39566, year: 2002, vol: 21, page: 7850, stat: Journal Article,

Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer
Li, Dangsheng; Li, Tong; Wang, Fang; Tian, Heather; Samuels, Herbert H
2002 Aug;22(16):5782-5792, Molecular & cellular biology
— id: 156065, year: 2002, vol: 22, page: 5782, stat: Journal Article,

NRC-Interacting Factor 1 Is a Novel Cotransducer That Interacts with and Regulates the Activity of the Nuclear Hormone Receptor Coactivator NRC
Mahajan, Muktar A; Murray, Audrey; Samuels, Herbert H
2002 Oct;22(19):6883-6894, Molecular & cellular biology
— id: 32315, year: 2002, vol: 22, page: 6883, stat: Journal Article,

Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation
Li D; Wang F; Samuels HH
2001 Dec;21(24):8371-8384, Molecular & cellular biology
— id: 26563, year: 2001, vol: 21, page: 8371, stat: Journal Article,

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors
Mathur M; Tucker PW; Samuels HH
2001 Apr;21(7):2298-2311, Molecular & cellular biology
— id: 20740, year: 2001, vol: 21, page: 2298, stat: Journal Article,

In silico discovery of novel Retinoic Acid Receptor agonist structures
Schapira M; Raaka BM; Samuels HH; Abagyan R
2001 ;1(1):1-1, BioMedCentral structural biology
— id: 20742, year: 2001, vol: 1, page: 1, stat: Journal Article,

A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein
Mahajan MA; Samuels HH
2000 Jul;20(14):5048-5063, Molecular & cellular biology
— id: 11637, year: 2000, vol: 20, page: 5048, stat: Journal Article,

Rational discovery of novel nuclear hormone receptor antagonists
Schapira M; Raaka BM; Samuels HH; Abagyan R
2000 Feb 1;97(3):1008-1013, Proceedings of the National Academy of Sciences of the United States of America
— id: 8562, year: 2000, vol: 97, page: 1008, stat: Journal Article,

A novel multifunctional motif in the amino-terminal A/B domain of T3Ralpha modulates DNA binding and receptor dimerization
Hadzic E; Habeos I; Raaka BM; Samuels HH
1998 Apr 24;273(17):10270-10278, Journal of biological chemistry
— id: 8033, year: 1998, vol: 273, page: 10270, stat: Journal Article,

TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors
Powers CA; Mathur M; Raaka BM; Ron D; Samuels HH
1998 Jan;12(1):4-18, Molecular endocrinology
— id: 7748, year: 1998, vol: 12, page: 4, stat: Journal Article,

Role of the conserved C-terminal region of thyroid hormone receptor-alpha in ligand-dependent transcriptional activation
Selmi-Ruby S; Casanova J; Malhotra S; Roussett B; Raaka BM; Samuels HH
1998 Mar 16;138(1-2):105-114, Molecular & cellular endocrinology
— id: 7788, year: 1998, vol: 138, page: 105, stat: Journal Article,

Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression
Qi JS; Desai-Yajnik V; Yuan Y; Samuels HH
1997 Dec;17(12):7195-7207, Molecular & cellular biology
— id: 12194, year: 1997, vol: 17, page: 7195, stat: Journal Article,

Interactions of the thyroid hormone receptor with the human immunodeficiency virus type I (HIV-1) long terminal repeat and the HIV-1 tat transactivator
DesaiYajnik, V; Samuels, HH
1996 MAR ;44(3):A237-A237, Journal of investigative medicine
— id: 52949, year: 1996, vol: 44, page: A237, stat: Journal Article,

Differential transactivation potentials of the thyroid hormone receptor alpha and beta isoforms
Hadzic, E; Samuels, HH
1996 MAR ;44(3):A237-A237, Journal of investigative medicine
— id: 52950, year: 1996, vol: 44, page: A237, stat: Journal Article,

Hormone-dependent and -independent transcriptional activation by thyroid hormone receptors are mediated by different mechanisms [see comments]
Helmer EB; Raaka BM; Samuels HH
1996 Feb;137(2):390-399, Endocrinology
— id: 6914, year: 1996, vol: 137, page: 390, stat: Journal Article,

Molecular interactions of p53 with thyroid hormone nuclear receptors
Qi, JS; DesaiYajnik, V; Samuels, HH
1996 MAR ;44(3):A234-A234, Journal of investigative medicine
— id: 52945, year: 1996, vol: 44, page: A234, stat: Journal Article,

Novel regulation of keratin gene expression by thyroid hormone and retinoid receptors
Tomic-Canic M; Day D; Samuels HH; Freedberg IM; Blumenberg M
1996 Jan 19;271(3):1416-1423, Journal of biological chemistry
— id: 8045, year: 1996, vol: 271, page: 1416, stat: Journal Article,

Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator
Desai-Yajnik V; Hadzic E; Modlinger P; Malhotra S; Gechlik G; Samuels HH
1995 Aug;69(8):5103-5112, Journal of virology
— id: 6817, year: 1995, vol: 69, page: 5103, stat: Journal Article,

A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB
Hadzic E; Desai-Yajnik V; Helmer E; Guo S; Wu S; Koudinova N; Casanova J; Raaka BM; Samuels HH
1995 Aug;15(8):4507-4517, Molecular & cellular biology
— id: 6831, year: 1995, vol: 15, page: 4507, stat: Journal Article,

The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation
Qi JS; Desai-Yajnik V; Greene ME; Raaka BM; Samuels HH
1995 Mar;15(3):1817-1825, Molecular & cellular biology
— id: 6718, year: 1995, vol: 15, page: 1817, stat: Journal Article,

Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
Casanova J; Helmer E; Selmi-Ruby S; Qi JS; Au-Fliegner M; Desai-Yajnik V; Koudinova N; Yarm F; Raaka BM; Samuels HH
1994 Sep;14(9):5756-5765, Molecular & cellular biology
— id: 8470, year: 1994, vol: 14, page: 5756, stat: Journal Article,

Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities
Hao E; Menke JB; Smith AM; Jones C; Geffner ME; Hershman JM; Wuerth JP; Samuels HH; Ways DK; Usala SJ
1994 Jul;8(7):841-851, Molecular endocrinology
— id: 20741, year: 1994, vol: 8, page: 841, stat: Journal Article,

A sequence in the rat Pit-1 gene promoter confers synergistic activation by glucocorticoids and protein kinase-C
Jong MT; Raaka BM; Samuels HH
1994 Oct;8(10):1320-1327, Molecular endocrinology
— id: 7901, year: 1994, vol: 8, page: 1320, stat: Journal Article,

The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation
Au-Fliegner M; Helmer E; Casanova J; Raaka BM; Samuels HH
1993 Sep;13(9):5725-5737, Molecular & cellular biology
— id: 8475, year: 1993, vol: 13, page: 5725, stat: Journal Article,

DIVERSE ACTIVITIES OF THE RETINOIC ACID AND THYROID-HORMONE RECEPTORS ARE MEDIATED BY THE CONSERVED 9TH HEPTAD REPEAT OF THE LIGAND-BINDING DOMAIN
AUFLIEGNER, M; HELMER, E; CASANOVA, J; RAAKA, BM; SAMUELS, HH
1993 APR ;41(2):A188-A188, Clinical research
— id: 54262, year: 1993, vol: 41, page: A188, stat: Journal Article,

Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat
Desai-Yajnik V; Samuels HH
1993 ;106:13-32, Transactions of the Association of American Physicians
— id: 13334, year: 1993, vol: 106, page: 13, stat: Journal Article,

The NF-kappa B and Sp1 motifs of the human immunodeficiency virus type 1 long terminal repeat function as novel thyroid hormone response elements
Desai-Yajnik V; Samuels HH
1993 Aug;13(8):5057-5069, Molecular & cellular biology
— id: 13095, year: 1993, vol: 13, page: 5057, stat: Journal Article,

Interaction of thyroid hormone and retinoic acid receptors on the regulation of the rat growth hormone gene promoter
Garcia-Villalba P; Au-Fliegner M; Samuels HH; Aranda A
1993 Mar 15;191(2):580-586, Biochemical & biophysical research communications
— id: 62149, year: 1993, vol: 191, page: 580, stat: Journal Article,

An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype
Geffner ME; Su F; Ross NS; Hershman JM; Van Dop C; Menke JB; Hao E; Stanzak RK; Eaton T; Samuels HH; et al.
1993 Feb;91(2):538-546, Journal of clinical investigation
— id: 62210, year: 1993, vol: 91, page: 538, stat: Journal Article,

The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element
Park HY; Davidson D; Raaka BM; Samuels HH
1993 Mar;7(3):319-330, Molecular endocrinology
— id: 13239, year: 1993, vol: 7, page: 319, stat: Journal Article,

Conformational changes in chicken thyroid hormone receptor alpha 1 induced by binding to ligand or to DNA
Toney JH; Wu L; Summerfield AE; Sanyal G; Forman BM; Zhu J; Samuels HH
1993 Jan 12;32(1):2-6, Biochemistry
— id: 62151, year: 1993, vol: 32, page: 2, stat: Journal Article,

REGULATION OF THE HIV-1 LTR - INTERACTIONS OF THYROID-HORMONE RECEPTOR WITH RXR, NF-KAPPA-B, SP1, AND TAT
YAJNIK, V; SAMUELS, HH
1993 APR ;41(2):A201-A201, Clinical research
— id: 54264, year: 1993, vol: 41, page: A201, stat: Journal Article,

A CONSERVED HEPTAD MEDIATES HETERODIMER BUT NOT HOMODIMER INTERACTIONS OF RETINOIC ACID AND THYROID-HORMONE RECEPTORS
AUFLIEGNER, M; SAMUELS, HH
1992 APR ;40(2):A301-A301, Clinical research
— id: 51998, year: 1992, vol: 40, page: A301, stat: Journal Article,

Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements
Brent GA; Williams GR; Harney JW; Forman BM; Samuels HH; Moore DD; Larsen PR
1992 Apr;6(4):502-514, Molecular endocrinology
— id: 62301, year: 1992, vol: 6, page: 502, stat: Journal Article,

EVIDENCE THAT T3 MEDIATED EFFECTS OF THYROID-HORMONE RECE
CASANOVA, J; AUFLIEGNER, M; HELMER, E; SAMUELS, HH
1992 APR ;40(2):A253-A253, Clinical research
— id: 51992, year: 1992, vol: 40, page: A253, stat: Journal Article,

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers
Forman BM; Casanova J; Raaka BM; Ghysdael J; Samuels HH
1992 Mar;6(3):429-442, Molecular endocrinology
— id: 13686, year: 1992, vol: 6, page: 429, stat: Journal Article,

NOVEL REGULATION OF THE PIT-1 PROMOTER BY GLUCOCORTICOIDS
JONG, MTC; RAAKA, BM; SAMUELS, HH
1992 APR ;40(2):A309-A309, Clinical research
— id: 52000, year: 1992, vol: 40, page: A309, stat: Journal Article,

THYROID-HORMONE RECEPTOR STIMULATES THE HIV-1-LTR BY BINDING TO AND ACTIVATING THE VIRAL NF-KAPPA-B AND SP1 DNA ELEMENTS
YAJNIK, V; SAMUELS, HH
1992 APR ;40(2):A301-A301, Clinical research
— id: 51997, year: 1992, vol: 40, page: A301, stat: Journal Article,

Influence of thyroid hormone on ADP-ribosylation of nuclear proteins in cultured GH1 cells
Aranda A; Copp RP; Pascual A; Samuels HH
1991 Feb 25;279(2):179-183, FEBS letters
— id: 63082, year: 1991, vol: 279, page: 179, stat: Journal Article,

Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine
Brent GA; Williams GR; Harney JW; Forman BM; Samuels HH; Moore DD; Larsen PR
1991 Apr;5(4):542-548, Molecular endocrinology
— id: 63080, year: 1991, vol: 5, page: 542, stat: Journal Article,

pEXPRESS: a family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro
Forman BM; Samuels HH
1991 Aug 30;105(1):9-15, Gene
— id: 13937, year: 1991, vol: 105, page: 9, stat: Journal Article,

Cloning and partial sequence of a cDNA for rabbit prothrombin
Karpatkin M; Tang ZC; Meer J; Blei F; Samuels HH
1991 Jun 15;62(6):757-763, Thrombosis research
— id: 13995, year: 1991, vol: 62, page: 757, stat: Journal Article,

Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding
Lucas PC; Forman BM; Samuels HH; Granner DK
1991 Oct;11(10):5164-5170, Molecular & cellular biology
— id: 62277, year: 1991, vol: 11, page: 5164, stat: Journal Article,

Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding
Lucas PC; Forman BM; Samuels HH; Granner DK
1991 Dec;11(12):6343-6343, Molecular & cellular biology
— id: 63079, year: 1991, vol: 11, page: 6343, stat: Journal Article,

A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene
Lucas PC; O'Brien RM; Mitchell JA; Davis CM; Imai E; Forman BM; Samuels HH; Granner DK
1991 Mar 15;88(6):2184-2188, Proceedings of the National Academy of Sciences of the United States of America
— id: 63081, year: 1991, vol: 88, page: 2184, stat: Journal Article,

DOMINANT NEGATIVE POTENCY OF MUTANT T3 RECE
MEIER, CA; MCCLASKEY, JH; USALA, SJ; DICKSTEIN, BM; MUCHMORE, P; BERCU, BB; SAMUELS, HH; WEINTRAUB, BD
1991 APR ;39(2):A293-A293, Clinical research
— id: 51616, year: 1991, vol: 39, page: A293, stat: Journal Article,

Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation
Selmi S; Samuels HH
1991 Jun 25;266(18):11589-11593, Journal of biological chemistry
— id: 13993, year: 1991, vol: 266, page: 11589, stat: Journal Article,

Oligomeric binding of T3 receptor is required for maximal T3 response
Williams GR; Harney JW; Forman BM; Samuels HH; Brent GA
1991 Oct 15;266(29):19636-19644, Journal of biological chemistry
— id: 62185, year: 1991, vol: 266, page: 19636, stat: Journal Article,

STIMULATORY, INHIBITORY, AND SYNERGISTIC EFFECTS OF RECEPTORS FOR THYROID-HORMONE AND RETINOIC ACID - ROLE OF LIGAND AND IMPLICATIONS FOR MORPHOGENESIS AND DEVELOPMENT
Au, M; Forman, BM; Casanova, J; Samuels, HH
1990 Apr;38(2):A475-A475, Clinical research
— id: 31968, year: 1990, vol: 38, page: A475, stat: Journal Article,

Dimerization among nuclear hormone receptors
Forman BM; Samuels HH
1990 Jul;2(7):587-594, New biologist
— id: 63084, year: 1990, vol: 2, page: 587, stat: Journal Article,

Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
Forman BM; Samuels HH
1990 Sep;4(9):1293-1301, Molecular endocrinology
— id: 62300, year: 1990, vol: 4, page: 1293, stat: Journal Article,

COOPERATIVE AND ANTAGONISTIC INTERACTIONS AMONG THYROID-HORMONE, VITAMIN-D AND RETINOIC ACID RECEPTOR HETERODIMERS
Forman, BM; Selmi, S; Casanova, J; Pike, JW; Samuels, HH
1990 Apr;38(2):A445-A445, Clinical research
— id: 31967, year: 1990, vol: 38, page: A445, stat: Journal Article,

THE GENERALIZED THYROID-HORMONE RESISTANCE SYNDROME - SIMULATION OF THE DOMINANT NEGATIVE PHENOTYPE INVITRO WITH LIGAND-BINDING MUTANTS OF THE THYROID-HORMONE RECEPTOR
Forman, BM; Yang, CR; Casanova, J; Samuels, HH
1990 Apr;38(2):A288-A288, Clinical research
— id: 31957, year: 1990, vol: 38, page: A288, stat: Journal Article,

The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters
Fox SR; Jong MT; Casanova J; Ye ZS; Stanley F; Samuels HH
1990 Jul;4(7):1069-1080, Molecular endocrinology
— id: 63083, year: 1990, vol: 4, page: 1069, stat: Journal Article,

THE GROWTH-HORMONE GENE PROMOTER BINDS A 38 KDA PROTEIN IN ASSOCIATION WITH THE PITUITARY-SPECIFIC TRANSCRIPTION FACTOR-PIT-1/GHF-1
Fox, SR; Copp, RP; Samuels, HH
1990 Apr;38(2):A296-A296, Clinical research
— id: 31958, year: 1990, vol: 38, page: A296, stat: Journal Article,

CELL-SPECIFIC REGULATION OF TRANSCRIPTION FROM THE BETA-2 ADRENERGIC-RECEPTOR PROMOTER BY THYROID AND GLUCOCORTICOID HORMONES
Helmer, E; Raaka, BM; Samuels, HH
1990 Apr;38(2):A475-A475, Clinical research
— id: 31969, year: 1990, vol: 38, page: A475, stat: Journal Article,

THE SYNTHETIC STEROID RU486 FUNCTIONS BOTH AS A GLUCOCORTICOID AGONIST AND ANTAGONIST
Raaka, BM; Erlich, WJ; Finnerty, M; Russo, MA; Samuels, HH
1990 Apr;38(2):A475-A475, Clinical research
— id: 31970, year: 1990, vol: 38, page: A475, stat: Journal Article,

Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes
Tomic M; Jiang CK; Epstein HS; Freedberg IM; Samuels HH; Blumenberg M
1990 Nov;1(12):965-973, Cell regulation
— id: 14309, year: 1990, vol: 1, page: 965, stat: Journal Article,

RETINOIC ACID AND THYROID-HORMONE FUNCTION INDEPENDENTLY AND SYNERGISTICALLY TO REGULATE GROWTH-HORMONE GENE-EXPRESSION
Au, M; Aranda, A; Samuels, HH
1989 Apr;37(2):A530-A530, Clinical research
— id: 31707, year: 1989, vol: 37, page: A530, stat: Journal Article,

Identification of an adenosine 3',5'-monophosphate (cAMP)-responsive region in the rat growth hormone gene: evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression
Copp RP; Samuels HH
1989 May;3(5):790-796, Molecular endocrinology
— id: 10665, year: 1989, vol: 3, page: 790, stat: Journal Article,

IDENTIFICATION OF A CAMP-RESPONSIVE REGION IN THE RAT GROWTH- HORMONE GENE - EVIDENCE FOR INDEPENDENT AND SYNERGISTIC EFFECTS OF CAMP AND THYROID-HORMONE
Copp, RP; Samuels, HH
1989 Apr;37(2):A357-A357, Clinical research
— id: 31698, year: 1989, vol: 37, page: A357, stat: Journal Article,

A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors
Forman BM; Yang CR; Au M; Casanova J; Ghysdael J; Samuels HH
1989 Oct;3(10):1610-1626, Molecular endocrinology
— id: 10483, year: 1989, vol: 3, page: 1610, stat: Journal Article,

LOCALIZATION OF A TRANSCRIPTIONAL REGULATORY DOMAIN OF A THYROID-HORMONE RECEPTOR C-ERBA THAT IS ACTIVE IN THE ABSENCE OF HORMONE-BINDING AND DNA-BINDING
Forman, BM; Yang, CR; Casanova, J; Samuels, HH
1989 Apr;37(2):A596-A596, Clinical research
— id: 31718, year: 1989, vol: 37, page: A596, stat: Journal Article,

IDENTIFICATION OF 2 NUCLEAR PROTEINS WHICH BIND SEQUENCES NECESSARY FOR CELL-SPECIFIC EXPRESSION OF BOTH THE GROWTH- HORMONE AND PROLACTIN GENES
Fox, SR; Forman, BM; Casanova, J; Stanley, F; Samuels, HH
1989 Apr;37(2):A596-A596, Clinical research
— id: 31719, year: 1989, vol: 37, page: A596, stat: Journal Article,

Characterization of the domain structure of chick c-erbA by deletion mutation: in vitro translation and cell transfection studies
Horowitz ZD; Yang CR; Forman BM; Casanova J; Samuels HH
1989 Jan;3(1):148-156, Molecular endocrinology
— id: 10856, year: 1989, vol: 3, page: 148, stat: Journal Article,

THE HERPES-SIMPLEX VIRAL THYMIDINE KINASE GENE PROMOTER IS TRANSCRIPTIONALLY ACTIVATED BY THYROID-HORMONE RECEPTOR
Park, HY; Samuels, HH
1989 Apr;37(2):A535-A535, Clinical research
— id: 31710, year: 1989, vol: 37, page: A535, stat: Journal Article,

The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunit
Raaka BM; Finnerty M; Samuels HH
1989 Feb;3(2):332-341, Molecular endocrinology
— id: 10729, year: 1989, vol: 3, page: 332, stat: Journal Article,

Thyroid hormone receptors and action: the 5'-flanking region of the rat growth hormone gene can mediate regulated gene expression
Samuels HH; Casanova J; Copp RP; Janocko L; Raaka BM; Sahnoun H; Yaffe BM
1989 ;15(4):495-545, Endocrine research
— id: 10779, year: 1989, vol: 15, page: 495, stat: Journal Article,

Regulation of gene expression by thyroid hormone
Samuels HH; Forman BM; Horowitz ZD; Ye ZS
1989 ;51:623-639, Annual review of physiology
— id: 10831, year: 1989, vol: 51, page: 623, stat: Journal Article,

Tumoral calcium pyrophosphate deposition disease
Sissons, H A; Steiner, G C; Bonar, F; May, M; Rosenberg, Z S; Samuels, H; Present, D
1989 ;18(2):79-87, Skeletal radiology
— id: 511592, year: 1989, vol: 18, page: 79, stat: Journal Article,

Cholera toxin affects nuclear ADP-ribosylation in GH1 cells
Aranda, A; Pascual, A; Copp, R; Samuels, H
1988 Jan;150(1):323-328, Biochemical & biophysical research communications
— id: 583062, year: 1988, vol: 150, page: 323, stat: Journal Article,

CHOLERA-TOXIN AFFECTS NUCLEAR ADP-RIBOSYLATION IN GH1 CELLS
ARANDA, A; PASCUAL, A; COPP, R; SAMUELS, H
1988 JAN 15 ;150(1):323-328, Biochemical & biophysical research communications
— id: 41863, year: 1988, vol: 150, page: 323, stat: Journal Article,

c-erbA protooncogenes mediate thyroid hormone-dependent and independent regulation of the rat growth hormone and prolactin genes
Forman BM; Yang CR; Stanley F; Casanova J; Samuels HH
1988 Oct;2(10):902-911, Molecular endocrinology
— id: 10956, year: 1988, vol: 2, page: 902, stat: Journal Article,

EXPRESSION OF THYROID-HORMONE RECEPTOR RELATED PROTO-ONCOGENE ERBA PROTEINS LEADS TO HORMONE-INDEPENDENT REGULATION OF RAT GROWTH-HORMONE AND PROLACTIN GENES
Forman, BM; Yang, CR; Stanley, F; Casanova, J; Samuels, HH
1988 Apr;36(3):A552-A552, Clinical research
— id: 31507, year: 1988, vol: 36, page: A552, stat: Journal Article,

Analysis of photoaffinity label derivatives to probe thyroid hormone receptor in human fibroblasts, GH1 cells, and soluble receptor preparations
Horowitz ZD; Sahnoun H; Pascual A; Casanova J; Samuels HH
1988 May 15;263(14):6636-6642, Journal of biological chemistry
— id: 11091, year: 1988, vol: 263, page: 6636, stat: Journal Article,

CHARACTERIZATION OF DOMAIN-STRUCTURE OF THE CHICK C-ERBA CDNA BY DELETION MUTATION - INVITRO TRANSLATION AND TRANSFECTION STUDIES
Horowitz, Z; Forman, BM; Yang, CR; Casanova, J; Samuels, HH
1988 Apr;36(3):A385-A385, Clinical research
— id: 31496, year: 1988, vol: 36, page: A385, stat: Journal Article,

Identification of the cis-acting elements and trans-acting factors that mediate cell-specific and thyroid hormone stimulation of growth hormone gene expression
Samuels HH; Aranda A; Casanova J; Copp RP; Flug F; Forman BM; Horowitz ZD; Janocko L; Park HY; Pascual A; et al.
1988 ;44:53-114, Recent progress in hormone research
— id: 63085, year: 1988, vol: 44, page: 53, stat: Journal Article,

Regulation of gene expression by thyroid hormone
Samuels HH; Forman BM; Horowitz ZD; Ye ZS
1988 Apr;81(4):957-967, Journal of clinical investigation
— id: 11135, year: 1988, vol: 81, page: 957, stat: Journal Article,

CONTROL OF RAT PROLACTIN GENE-EXPRESSION - L-T3 HAS BOTH POSITIVE AND NEGATIVE EFFECTS IN DIFFERENT CELL-LINES
Stanley, FM; Casanova, J; Samuels, HH
1988 Apr;36(3):A391-A391, Clinical research
— id: 31497, year: 1988, vol: 36, page: A391, stat: Journal Article,

Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation
Ye ZS; Forman BM; Aranda A; Pascual A; Park HY; Casanova J; Samuels HH
1988 Jun 5;263(16):7821-7829, Journal of biological chemistry
— id: 11066, year: 1988, vol: 263, page: 7821, stat: Journal Article,

Rat growth hormone gene expression: both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation
Ye ZS; Forman BM; Park HY; Casanova J; Samuels HH
1988 ;101:42-53, Transactions of the Association of American Physicians
— id: 11262, year: 1988, vol: 101, page: 42, stat: Journal Article,

RAT GROWTH-HORMONE GENE-EXPRESSION - BOTH CELL-SPECIFIC AND THYROID-HORMONE RESPONSE ELEMENTS ARE REQUIRED FOR THYROID- HORMONE REGULATION
Ye, ZS; Forman, BM; Park, HY; Casanova, J; Samuels, HH
1988 Apr;36(3):A610-A610, Clinical research
— id: 31515, year: 1988, vol: 36, page: A610, stat: Journal Article,

cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone
Flug F; Copp RP; Casanova J; Horowitz ZD; Janocko L; Plotnick M; Samuels HH
1987 May 5;262(13):6373-6382, Journal of biological chemistry
— id: 63086, year: 1987, vol: 262, page: 6373, stat: Journal Article,

Photoaffinity labeling of thyroid hormone receptors
Horowitz ZD; Samuels HH
1987 ;33(2-3):317-332, Pharmacology & therapeutics
— id: 11421, year: 1987, vol: 33, page: 317, stat: Journal Article,

CONTROL OF GROWTH-HORMONE GENE-EXPRESSION BY THYROID-HORMONE
Samuels, HH; Copp, RP; Casanova, J; Janocko, L; Plotnick, M; Ye, ZS
1987 Mar 1;46(3):791-791, Federation proceedings (Federation of American Societies for Experimental Biology)
— id: 31266, year: 1987, vol: 46, page: 791, stat: Journal Article,

Cell- and sequence-specific binding of nuclear proteins to 5'-flanking DNA of the rat growth hormone gene
Ye ZS; Samuels HH
1987 May 5;262(13):6313-6317, Journal of biological chemistry
— id: 63087, year: 1987, vol: 262, page: 6313, stat: Journal Article,

LOCALIZATION OF HORMONE REGULATORY ELEMENTS OF THE RAT GROWTH-HORMONE GENE
FLUG, F; PLOTNIK, M; CASANOVA, J; COPP, RP; SAMUELS, HH
1986 APR ;34(2):A714-A714, Clinical research
— id: 41411, year: 1986, vol: 34, page: A714, stat: Journal Article,

Stimulation of facilitated [3H]uridine transport by thyroid hormone in GH1 cells. Evidence for regulation by the thyroid hormone nuclear receptor
Stanley F; Tsai JS; Samuels HH
1986 Jul 15;261(20):9400-9404, Journal of biological chemistry
— id: 62194, year: 1986, vol: 261, page: 9400, stat: Journal Article,

5'-Flanking DNA of the rat growth hormone gene mediates regulated expression by thyroid hormone
Casanova J; Copp RP; Janocko L; Samuels HH
1985 Sep 25;260(21):11744-11748, Journal of biological chemistry
— id: 63089, year: 1985, vol: 260, page: 11744, stat: Journal Article,

Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form
McIntyre WR; Samuels HH
1985 Jan 10;260(1):418-427, Journal of biological chemistry
— id: 63090, year: 1985, vol: 260, page: 418, stat: Journal Article,

Effects of molybdate on steroid receptors in intact GH1 cells. Evidence for dissociation of an intracellular 10 S receptor oligomer prior to nuclear accumulation
Raaka BM; Finnerty M; Sun E; Samuels HH
1985 Nov 15;260(26):14009-14015, Journal of biological chemistry
— id: 63088, year: 1985, vol: 260, page: 14009, stat: Journal Article,

MOLYBDATE INHIBITS NUCLEAR ACCUMULATION AND INCREASES THE HALF-LIFE OF THE ESTROGEN-RECEPTOR IN GH CELLS
Raaka, BM; Finnerty, M; Samuels, HH
1985 ;44(5):1474-1474, Federation proceedings (Federation of American Societies for Experimental Biology)
— id: 30952, year: 1985, vol: 44, page: 1474, stat: Journal Article,

5'-flanking DNA sequences of the growth hormone gene mediates thyroid hormone stimulation of growth hormone gene transcription
Samuels HH; Casanova J; Copp RP; Janocko L
1985 ;98:55-65, Transactions of the Association of American Physicians
— id: 63091, year: 1985, vol: 98, page: 55, stat: Journal Article,

5'-FLANKING DNA-SEQUENCES OF THE GROWTH-HORMONE GENE MEDIATE THYROID-HORMONE STIMULATION OF GROWTH-HORMONE GENE- TRANSCRI
Samuels, HH; Casanova, J; Copp, RP; Janocko, L
1985 ;33(2):A601-A601, Clinical research
— id: 30933, year: 1985, vol: 33, page: A601, stat: Journal Article,

Modulation of thyroid hormone nuclear receptors by cholera toxin in cultured GH1 cells
Aranda A; Samuels HH
1984 May 25;259(10):6110-6116, Journal of biological chemistry
— id: 62193, year: 1984, vol: 259, page: 6110, stat: Journal Article,

Photoaffinity labeling of thyroid hormone nuclear receptors. Influence of n-butyrate and analysis of the half-lives of the 57,000 and 47,000 molecular weight receptor forms
Casanova J; Horowitz ZD; Copp RP; McIntyre WR; Pascual A; Samuels HH
1984 Oct 10;259(19):12084-12091, Journal of biological chemistry
— id: 63092, year: 1984, vol: 259, page: 12084, stat: Journal Article,

PHOTOAFFINITY-LABELING OF THYROID-HORMONE RECEPTORS - ANALYSIS OF THE NUCLEAR-INTERACTIONS, SYNTHETIC RATE, AND HALF-LIFE OF THE 57K AND K-47 RECEPTOR FORMS
HOROWITZ, ZD; CASANOVA, J; SAMUELS, HH
1984 ;32(2):A546-A546, Clinical research
— id: 40982, year: 1984, vol: 32, page: A546, stat: Journal Article,

Hormonal regulation of the growth hormone gene. Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes
Yaffe BM; Samuels HH
1984 May 25;259(10):6284-6291, Journal of biological chemistry
— id: 63094, year: 1984, vol: 259, page: 6284, stat: Journal Article,

HORMONAL-REGULATION OF GROWTH-HORMONE GENE-TRANSCRIPTION IS DIRECTLY INFLUENCED BY THE LEVEL OF NUCLEAR THYROID HORMONE-RECEPTOR COMPLEXES
YAFFE, BM; SAMUELS, HH
1984 ;32(2):A488-A488, Clinical research
— id: 40978, year: 1984, vol: 32, page: A488, stat: Journal Article,

Molecular basis of thyroid hormone action
Oppenheimer, Jack H.; Samuels, Herbert H.; Apriletti, James W
New York : Academic Press, 1983,
— id: 111, year: 1983, vol: , page: , stat: ,

Cholera toxin decreases thyroid hormone receptor in GH1 cells by a cAMP independent mechanism
Aranda, A; Casanova, J; Samuels, HH
1982 ;43(3):-, Annales d'endocrinologie
— id: 579022, year: 1982, vol: 43, page: , stat: Journal Article,

An equilibrium model for hormone-mediated glucocorticoid receptor activation and translocation
Raaka, BM; Samuels, HH
1982 ;30(2):-, Clinical research
— id: 579232, year: 1982, vol: 30, page: , stat: Journal Article,

Cyclic AMP regulation of growth hormone mRNA is dependent on thyroid and glucocorticoid action
Samuels, HH; Stanley, F; Hollander, P; Casanova, J
1979 ;27(2):-, Clinical research
— id: 581202, year: 1979, vol: 27, page: , stat: Journal Article,

Multihormonal control of the growth hormone genome in cultured GH1 cells
Samuels, HH; Shapiro, LE; Horowitz, ZD; Klein, D
1978 ;26(3):-, Clinical research
— id: 581372, year: 1978, vol: 26, page: , stat: Journal Article,