Bernardo Rudy

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Bernardo Rudy

Valentino D.B. Mazzia, MD, JD Professor of Anesthesiology, Department of Anesthesiology, Perioperative Care, and Pain Medicine
Professor, Department of Neuroscience and Physiology

Vice Chair of Research, Anesthesiology, Perioperative Care and Pain Medicine

Contact Info

Address
522 First Avenue
New York, NY 10016

212-263-0431
Bernardo.Rudy@nyumc.org

Education

— Dr. Rudy received his M.D. degree from the University of Mexico, Mexico City, Mexico, Medical Education

Research Summary

We are interested in how neuronal activity regulates behavior. Toward this goal, we study how brain function depends on the properties of individual neurons and the circuits they make with other neurons. Our main focus is on the cerebral cortex, the largest and most complex part of the mammalian brain. The computations that take place in this brain area are essential for normal perception, memory, motor control, and cognition. It is where acquired sensory information about the external world is integrated with past experience (memories) in order to predict and command appropriate behavior. We aim to understand how the basic properties of different types of cortical neurons, the building blocks of the cerebral cortex, and their connections contribute to behavior. We study the diversity of cortical neurons and the connectivity among different cell types, as well as the ion channels and other intrinsic factors that control their excitability, the dynamic properties of their synapses and how these properties are regulated by neuromodulators. We then manipulate neuronal properties and cortical circuits and study how these manipulations affect function. We are currently emphasizing two areas of research: i) characterization of the circuits by which distinct GABAergic interneurons shape cortical information processing and ii) the mechanisms by which acetylcholine, a neuromodulator with key roles in the control of cognitive function, modulates cortical function. To address these questions, we use a multidisciplinary approach that combines molecular, genetic, and anatomical techniques with electrophysiological, imaging, and optogenetic methods in vitro and in vivo as well as behavioral methods. We hope to unravel cellular and circuit mechanisms that mediate cortical function and gain insight into how dysfunction of ion channels, cortical neurons, and neuromodulatory systems contributes to neurological and psychiatric disease.

Research Keywords

organization and function of neocortical circuits, channels and transporters, molecular, cellular, & translational neuroscience

Layer-specific modulation of neocortical dendritic inhibition during active wakefulness
Munoz, William; Tremblay, Robin; Levenstein, Daniel; Rudy, Bernardo. Layer-specific modulation of neocortical dendritic inhibition during active wakefulness. Science. 2017 Mar 03;355:954-959 (2471292)

A viral strategy for targeting and manipulating interneurons across vertebrate species
Dimidschstein, Jordane; Chen, Qian; Tremblay, Robin; Rogers, Stephanie L; Saldi, Giuseppe-Antonio; Guo, Lihua; Xu, Qing; Liu, Runpeng; Lu, Congyi; Chu, Jianhua; Avery, Michael C; Rashid, Mohammad S; Baek, Myungin; Jacob, Amanda L; Smith, Gordon B; Wilson, Daniel E; Kosche, Georg; Kruglikov, Illya; Rusielewicz, Tomasz; Kotak, Vibhakar C; Mowery, Todd M; Anderson, Stewart A; Callaway, Edward M; Dasen, Jeremy S; Fitzpatrick, David; Fossati, Valentina; Long, Michael A; Noggle, Scott; Reynolds, John H; Sanes, Dan H; Rudy, Bernardo; Feng, Guoping; Fishell, Gord. A viral strategy for targeting and manipulating interneurons across vertebrate species. Nature neuroscience. 2016 Dec;19(12):1743-1749 (2297132)

Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
He, Miao; Tucciarone, Jason; Lee, SooHyun; Nigro, Maximiliano Jose; Kim, Yongsoo; Levine, Jesse Maurica; Kelly, Sean Michael; Krugikov, Illya; Wu, Priscilla; Chen, Yang; Gong, Lin; Hou, Yongjie; Osten, Pavel; Rudy, Bernardo; Huang, Z Josh. Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016 Sep 21;91(6):1228-1243 (2246882)

Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex"
Barth, Alison; Burkhalter, Andreas; Callaway, Edward M; Connors, Barry W; Cauli, Bruno; DeFelipe, Javier; Feldmeyer, Dirk; Freund, Tamas; Kawaguchi, Yasuo; Kisvarday, Zoltan; Kubota, Yoshiyuki; McBain, Chris; Oberlaender, Marcel; Rossier, Jean; Rudy, Bernardo; Staiger, Jochen F; Somogyi, Peter; Tamas, Gabor; Yuste, Rafael. Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex". Science. 2016 Sep 09;353(6304):1108-1108 (2238722)

Drosophila SLC5A11 Mediates Hunger by Regulating K+ Channel Activity
Park, Jin-Yong; Dus, Monica; Kim, Seonil; Abu, Farhan; Kanai, Makoto I; Rudy, Bernardo; Suh, Greg S B. Drosophila SLC5A11 Mediates Hunger by Regulating K+ Channel Activity. Current biology. CB. 2016 Aug 08;26(15):1965-1974 (2180102)