Ana Rodriguez

Biosketch / Results /

Ana Rodriguez Fernandez

Associate Professor, Department of Microbiology
Co-Director, Anopheles Insectary

Contact Info

Address
341 East 25th Street
New York, NY 10016

212/263-6757
Ana.RodriguezFernandez@nyumc.org

Research Summary

Our lab studies two different parasites, Plasmodium, which causes Malaria and Trypanosoma cruzi, which causes Chagas disease. Malaria is a devastating disease that causes more than half a million deaths per year, mainly among children in third world countries. There is an urgent need for new strategies to control malaria, but there is a lack of detailed knowledge of the basic biological processes of Plasmodium, that would allow faster development of anti-malaria drugs and vaccines. A main interest of our laboratory is the study of malaria-induced inflammatory pathology and its implications in the pathology of disease, including cerebral malaria and severe anemia. We also intend to develop effective drugs against Chagas Disease. In collaboration with GSK, we have performed high through put screenings of intracellular Trypanosoma cruzi, to find compounds with anti-trypanosomal activities. Selected compounds are being tested for efficacy in mice.

http://www.med.nyu.edu/microbiology-parasitology/faculty/rodriguez-lab-microbiology

Research Interests

Plasmodium-induced inflammation and immune response. Drug development for Chagas disease.|malaria immune response

Research Keywords

malaria, inflammation, Plasmodium, cerebral malaria, severe anemia

Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?
Amata, Emanuele; Xi, Hualin; Colmenarejo, Gonzalo; Gonzalez-Diaz, Rosario; Cordon-Obras, Carlos; Berlanga, Manuela; Manzano, Pilar; Erath, Jessey; Roncal, Norma E; Lee, Patricia J; Leed, Susan E; Rodriguez, Ana; Sciotti, Richard J; Navarro, Miguel; Pollastri, Michael P. Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?. ACS infectious diseases. 2016 Jan 17;2(3):180-186 (2051972)

Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia
Fernandez-Arias, Cristina; Rivera-Correa, Juan; Gallego-Delgado, Julio; Rudlaff, Rachel; Fernandez, Clemente; Roussel, Camille; Gotz, Anton; Gonzalez, Sandra; Mohanty, Akshaya; Mohanty, Sanjib; Wassmer, Samuel; Buffet, Pierre; Ndour, Papa Alioune; Rodriguez, Ana. Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia. Cell host & microbe. 2016 Feb 10;19(2):194-203 (1948742)

Angiotensin receptors and beta-catenin regulate brain endothelial integrity in malaria
Gallego-Delgado, Julio; Basu-Roy, Upal; Ty, Maureen; Alique, Matilde; Fernandez-Arias, Cristina; Movila, Alexandru; Gomes, Pollyanna; Weinstock, Ada; Xu, Wenyue; Edagha, Innocent; Wassmer, Samuel C; Walther, Thomas; Ruiz-Ortega, Marta; Rodriguez, Ana. Angiotensin receptors and beta-catenin regulate brain endothelial integrity in malaria. Journal of clinical investigation. 2016 Sep 19;:?-? (2255212)

The High Blood Pressure-Malaria Protection Hypothesis
Gallego-Delgado, Julio; Walther, Thomas; Rodriguez, Ana. The High Blood Pressure-Malaria Protection Hypothesis. Circulation research. 2016 Sep 22;:?-? (2254972)

Automated High-Content Assay for Compounds Selectively Toxic to Trypanosoma cruzi in a Myoblastic Cell Line
Alonso-Padilla, Julio; Cotillo, Ignacio; Presa, Jesus L; Cantizani, Juan; Pena, Imanol; Bardera, Ana I; Martin, Jose J; Rodriguez, Ana. Automated High-Content Assay for Compounds Selectively Toxic to Trypanosoma cruzi in a Myoblastic Cell Line. PLoS neglected tropical diseases. 2015 Jan 23;9(1):e0003493-e0003493 e0003493 (1448732)