Richard Tsien

Biosketch / Results /

Richard Tsien, D.Phil.

Druckenmiller Professor of Neuroscience; Director Neuroscience Institute; Chair Dept of Physiology and Neuroscience
Departments of Neuroscience and Physiology (Neuro/Phys) and Office of Science and Research (Neuroscience Institute-Chair)

Contact Info

Address
450 East 29th Street
Floor 9th Room 902
Alexandria Building
New York, NY 10016

646-501-4520
Richard.Tsien@nyumc.org


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Education

1966 — Massachusetts Institute of Technology, Cambridge, MA, Electrical Engineering, Graduate Education
1970 — Oxford University, Oxford, England, D. Phil., Biophysics,, Graduate Education

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Research Summary

We are studying how the location and identity of presynaptic calcium channels is regulated. Voltage-gated Ca2+ channels provide the critical link between the firing of a presynaptic nerve terminal and its release of neurotransmitter. The Ca2+ channels must be positioned very close to sites of vesicle fusion, and come in diverse forms with distinct activity-dependence, responsiveness to GABA, dopamine, acetylcholine and other neuromodulators, and susceptibility to neurological disorders such as migraine, ataxia or dystonia. Our working hypothesis involves molecular "slots" for particular types of channels. Slots regulate the mix of channel types and also help explain how defective channels might displace normal ones in genetically dominant disorders.

Our lab is particularly interested in studying multiple modes of synaptic vesicle fusion. The opening of Ca2+ channels drives at least two distinct forms of fusion. In the classical mode, the vesicle membrane fully merges with and flattens into the presynaptic membrane (full collapse fusion). In a newly characterized mode, termed "kiss-and-run," the connection between the vesicle interior and the external medium lasts long enough to allow passage of neurotransmitter, but the connection is severed before the identity of the vesicle is lost. We study the dynamic properties and functional implications of both fusion modes by loading single synaptic vesicles with single photoluminescent reporter particles?quantum dots. Sharp distinctions between full collapse fusion and kiss-and-run are now in hand. Experiments are underway to monitor the same fusion event optically and electrophysiologically.

One area of intense attention in our lab is the fundamental unit of cell-cell communication between brain neurons: quantal synaptic transmission. Presynaptic release of a packet of neurotransmitter, for example, glutamate, causes activation of postsynaptic receptors and a brief flow of current that promotes firing of the postsynaptic cell. We work on neuronal mechanisms that allow synapses to adapt to a sudden or long-lasting change in their level of activity. For example, blockade of impulses or of postsynaptic glutamate receptors causes a cascade of biochemical events that eventually leads to readjustment of critical molecular players on both sides of the synapse. We use state-of-the art methods to pin down the cell biology of changes in synaptic strength, of importance for adaptation of brain networks in learning and memory. Ongoing work in cultures of isolated neurons and brain slices.

We study how synaptic transmission and depolarization cause changes in neuronal gene expression. Despite its importance, signaling from synapse or surface membrane to nucleus is only partly understood. One example of such signaling involves a local increase in Ca2+ concentration near a class of Ca2+ channels (L-type) different from those that trigger presynaptic transmitter release, subsequently leading to activation of an exemplar transcription factor, CREB, a regulator of transcription of many important neuronal genes. Our approach is to combine physiological approaches (how fast, how steeply voltage-dependent, how is signal transduced) and biochemical experiments using cDNA microarrays (which genes, in what context, what relationship to learning and memory).

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

CaV1.2 Calcium Channels: Just Cut Out to Be Regulated?
Groth, Rachel D; Tirko, Natasha N; Tsien, Richard W
2014 Jun;82(5):939-940, Neuron
— id: 1061872, year: 2014, vol: 82, page: 939, stat: Journal Article,

Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission
Alabi, AbdulRasheed A; Tsien, Richard W
2013 ;75:393-422, Annual review of physiology
— id: 306382, year: 2013, vol: 75, page: 393, stat: Journal Article,

AMPA receptor exchange underlies transient memory destabilization on retrieval
Hong, Ingie; Kim, Jeongyeon; Kim, Jihye; Lee, Sukwon; Ko, Hyoung-Gon; Nader, Karim; Kaang, Bong-Kiun; Tsien, Richard W; Choi, Sukwoo
2013 May;110(20):8218-8223, Proceedings of the National Academy of Sciences of the United States of America
— id: 421402, year: 2013, vol: 110, page: 8218, stat: Journal Article,

GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal
Lee, Sukwon; Song, Beomjong; Kim, Jeongyeon; Park, Kyungjoon; Hong, Ingie; An, Bobae; Song, Sangho; Lee, Jiwon; Park, Sungmo; Kim, Jihye; Park, Dongeun; Lee, C Justin; Kim, Kyungjin; Shin, Ki Soon; Tsien, Richard W; Choi, Sukwoo
2013 Oct;16(10):1436-1444, Nature neuroscience
— id: 575922, year: 2013, vol: 16, page: 1436, stat: Journal Article,

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons
Owen, Scott F; Tuncdemir, Sebnem N; Bader, Patrick L; Tirko, Natasha N; Fishell, Gord; Tsien, Richard W
2013 Aug;:458-462, Nature
— id: 489582, year: 2013, vol: , page: 458, stat: Journal Article,

Ca2+ channel nanodomains boost local Ca2+ amplitude
Tadross, Michael R; Tsien, Richard W; Yue, David T
2013 Sep;110(39):15794-15799, Proceedings of the National Academy of Sciences of the United States of America
— id: 576102, year: 2013, vol: 110, page: 15794, stat: Journal Article,

Synaptic vesicle pools and dynamics
Alabi, AbdulRasheed A; Tsien, Richard W
2012 Aug;4(8):a013680-a013680 a013680, Cold Spring Harbor perspectives in biology
— id: 489592, year: 2012, vol: 4, page: a013680, stat: Journal Article,

An improved test for detecting multiplicative homeostatic synaptic scaling
Kim, Jimok; Tsien, Richard W; Alger, Bradley E
2012 ;7(5):e37364-e37364 e37364, PLoS ONE
— id: 489612, year: 2012, vol: 7, page: e37364, stat: Journal Article,

pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity
Li, Yulong; Tsien, Richard W
2012 ;15(7):1047-1053, Nature neuroscience
— id: 173972, year: 2012, vol: 15, page: 1047, stat: Journal Article,

Exploring the dominant role of Cav1 channels in signalling to the nucleus
Ma, Huan; Cohen, Samuel; Li, Boxing; Tsien, Richard W
2012 ;33(1):203-209, Bioscience reports
— id: 213912, year: 2012, vol: 33, page: 203, stat: Journal Article,

Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity
Mitra, Ananya; Mitra, Siddhartha S; Tsien, Richard W
2012 Feb;15(2):250-257, Nature neuroscience
— id: 489622, year: 2012, vol: 15, page: 250, stat: Journal Article,

Influence of synaptic vesicle position on release probability and exocytotic fusion mode
Park, Hyokeun; Li, Yulong; Tsien, Richard W
2012 Mar;335(6074):1362-1366, Science
— id: 489602, year: 2012, vol: 335, page: 1362, stat: Journal Article,

Ca(V)1 and Ca(V)2 Channels Engage Distinct Modes of Ca(2+) Signaling to Control CREB-Dependent Gene Expression
Wheeler, Damian G; Groth, Rachel D; Ma, Huan; Barrett, Curtis F; Owen, Scott F; Safa, Parsa; Tsien, Richard W
2012 May;149(5):1112-1124, Cell
— id: 169566, year: 2012, vol: 149, page: 1112, stat: Journal Article,

Mouse model of Timothy syndrome recapitulates triad of autistic traits
Bader, Patrick L; Faizi, Mehrdad; Kim, Leo H; Owen, Scott F; Tadross, Michael R; Alfa, Ronald W; Bett, Glenna C L; Tsien, Richard W; Rasmusson, Randall L; Shamloo, Mehrdad
2011 Sep 13;108(37):15432-15437, Proceedings of the National Academy of Sciences of the United States of America
— id: 138419, year: 2011, vol: 108, page: 15432, stat: Journal Article,

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: activation of beta1-adrenergic receptor by xamoterol as a potential cognitive enhancer
Faizi, Mehrdad; Bader, Patrick L; Tun, Christine; Encarnacion, Angelo; Kleschevnikov, Alexander; Belichenko, Pavel; Saw, Nay; Priestley, Matthew; Tsien, Richard W; Mobley, William C; Shamloo, Mehrdad
2011 Aug;43(2):397-413, Neurobiology of disease
— id: 136716, year: 2011, vol: 43, page: 397, stat: Journal Article,

Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons
Groth, Rachel D; Lindskog, Maria; Thiagarajan, Tara C; Li, Li; Tsien, Richard W
2011 Jan 11;108(2):828-833, Proceedings of the National Academy of Sciences of the United States of America
— id: 136719, year: 2011, vol: 108, page: 828, stat: Journal Article,

Excitation-transcription coupling in sympathetic neurons and the molecular mechanism of its initiation
Ma, Huan; Groth, Rachel D; Wheeler, Damian G; Barrett, Curtis F; Tsien, Richard W
2011 May;70(1):2-8, Neuroscience research
— id: 136718, year: 2011, vol: 70, page: 2, stat: Journal Article,

MicroRNA-mediated conversion of human fibroblasts to neurons
Yoo, Andrew S; Sun, Alfred X; Li, Li; Shcheglovitov, Aleksandr; Portmann, Thomas; Li, Yulong; Lee-Messer, Chris; Dolmetsch, Ricardo E; Tsien, Richard W; Crabtree, Gerald R
2011 Aug 11;476(7359):228-231, Nature
— id: 136717, year: 2011, vol: 476, page: 228, stat: Journal Article,

Inhibitory role for GABA in autoimmune inflammation
Bhat, Roopa; Axtell, Robert; Mitra, Ananya; Miranda, Melissa; Lock, Christopher; Tsien, Richard W; Steinman, Lawrence
2010 Feb 9;107(6):2580-2585, Proceedings of the National Academy of Sciences of the United States of America
— id: 136723, year: 2010, vol: 107, page: 2580, stat: Journal Article,

Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses
Cao, Yu-Qing; Tsien, Richard W
2010 Mar 31;30(13):4536-4546, Journal of neuroscience
— id: 136722, year: 2010, vol: 30, page: 4536, stat: Journal Article,

Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity
Lindskog, Maria; Li, Li; Groth, Rachel D; Poburko, Damon; Thiagarajan, Tara C; Han, Xue; Tsien, Richard W
2010 Dec 14;107(50):21806-21811, Proceedings of the National Academy of Sciences of the United States of America
— id: 136720, year: 2010, vol: 107, page: 21806, stat: Journal Article,

Inhibitory neurons hear themselves during development
Owen, Scott F; Tsien, Richard W
2010 Apr 29;66(2):164-166, Neuron
— id: 136721, year: 2010, vol: 66, page: 164, stat: Journal Article,

Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B
Espinosa, J Sebastian; Wheeler, Damian G; Tsien, Richard W; Luo, Liqun
2009 Apr 30;62(2):205-217, Neuron
— id: 136724, year: 2009, vol: 62, page: 205, stat: Journal Article,

The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles
Zhang, Qi; Li, Yulong; Tsien, Richard W
2009 Mar 13;323(5920):1448-1453, Science
— id: 136725, year: 2009, vol: 323, page: 1448, stat: Journal Article,

The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels
Barrett, Curtis F; Tsien, Richard W
2008 Feb 12;105(6):2157-2162, Proceedings of the National Academy of Sciences of the United States of America
— id: 136731, year: 2008, vol: 105, page: 2157, stat: Journal Article,

A role for retinoic acid in homeostatic plasticity
Groth, Rachel D; Tsien, Richard W
2008 Oct 23;60(2):192-194, Neuron
— id: 136727, year: 2008, vol: 60, page: 192, stat: Journal Article,

Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation
Kim, Jimok; Tsien, Richard W
2008 Jun 26;58(6):925-937, Neuron
— id: 136729, year: 2008, vol: 58, page: 925, stat: Journal Article,

Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo
Liao, Yaping Joyce; Safa, Parsa; Chen, Yi-Ren; Sobel, Raymond A; Boyden, Edward S; Tsien, Richard W
2008 Feb 19;105(7):2705-2710, Proceedings of the National Academy of Sciences of the United States of America
— id: 136730, year: 2008, vol: 105, page: 2705, stat: Journal Article,

Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels
Watase, Kei; Barrett, Curtis F; Miyazaki, Taisuke; Ishiguro, Taro; Ishikawa, Kinya; Hu, Yuanxin; Unno, Toshinori; Sun, Yaling; Kasai, Sayumi; Watanabe, Masahiko; Gomez, Christopher M; Mizusawa, Hidehiro; Tsien, Richard W; Zoghbi, Huda Y
2008 Aug 19;105(33):11987-11992, Proceedings of the National Academy of Sciences of the United States of America
— id: 136728, year: 2008, vol: 105, page: 11987, stat: Journal Article,

CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling
Wheeler, Damian G; Barrett, Curtis F; Groth, Rachel D; Safa, Parsa; Tsien, Richard W
2008 Dec 1;183(5):849-863, Journal of cell biology
— id: 136726, year: 2008, vol: 183, page: 849, stat: Journal Article,

The sequence of events that underlie quantal transmission at central glutamatergic synapses
Lisman, John E; Raghavachari, Sridhar; Tsien, Richard W
2007 Aug;8(8):597-609, Nature reviews. Neuroscience
— id: 136733, year: 2007, vol: 8, page: 597, stat: Journal Article,

Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes
Shcherbakova, Olga G; Hurt, Carl M; Xiang, Yang; Dell'Acqua, Mark L; Zhang, Qi; Tsien, Richard W; Kobilka, Brian K
2007 Feb 12;176(4):521-533, Journal of cell biology
— id: 136735, year: 2007, vol: 176, page: 521, stat: Journal Article,

LTP and adaptation to inactivity: overlapping mechanisms and implications for metaplasticity
Thiagarajan, Tara C; Lindskog, Maria; Malgaroli, Antonio; Tsien, Richard W
2007 Jan;52(1):156-175, Neuropharmacology
— id: 136736, year: 2007, vol: 52, page: 156, stat: Journal Article,

Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator
Tour, Oded; Adams, Stephen R; Kerr, Rex A; Meijer, Rene M; Sejnowski, Terrence J; Tsien, Richard W; Tsien, Roger Y
2007 Jul;3(7):423-431, Nature Chemical Biology
— id: 136734, year: 2007, vol: 3, page: 423, stat: Journal Article,

A remembrance of Professor TP FENG
Tsien, Richard W
2007 Dec;59(6):713-715, Sheng li xue bao : [Acta physiologica Sinica]
— id: 489632, year: 2007, vol: 59, page: 713, stat: Journal Article,

Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles
Zhang, Qi; Cao, Yu-Qing; Tsien, Richard W
2007 Nov 6;104(45):17843-17848, Proceedings of the National Academy of Sciences of the United States of America
— id: 136732, year: 2007, vol: 104, page: 17843, stat: Journal Article,

Selective engagement of plasticity mechanisms for motor memory storage
Boyden, Edward S; Katoh, Akira; Pyle, Jason L; Chatila, Talal A; Tsien, Richard W; Raymond, Jennifer L
2006 Sep 21;51(6):823-834, Neuron
— id: 136737, year: 2006, vol: 51, page: 823, stat: Journal Article,

Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion
Harata, Nobutoshi C; Aravanis, Alexander M; Tsien, Richard W
2006 Jun;97(6):1546-1570, Journal of neurochemistry
— id: 136739, year: 2006, vol: 97, page: 1546, stat: Journal Article,

Frequency-dependent kinetics and prevalence of kiss-and-run and reuse at hippocampal synapses studied with novel quenching methods
Harata, Nobutoshi C; Choi, Sukwoo; Pyle, Jason L; Aravanis, Alexander M; Tsien, Richard W
2006 Jan 19;49(2):243-256, Neuron
— id: 136740, year: 2006, vol: 49, page: 243, stat: Journal Article,

L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors
Wheeler, Damian G; Barrett, Curtis F; Tsien, Richard W
2006 Jul;51(1):27-36, Neuropharmacology
— id: 136738, year: 2006, vol: 51, page: 27, stat: Journal Article,

Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel
Barrett, Curtis F; Cao, Yu-Qing; Tsien, Richard W
2005 Jun 24;280(25):24064-24071, Journal of biological chemistry
— id: 136743, year: 2005, vol: 280, page: 24064, stat: Journal Article,

Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission
Cao, Yu-Qing; Tsien, Richard W
2005 Feb 15;102(7):2590-2595, Proceedings of the National Academy of Sciences of the United States of America
— id: 136744, year: 2005, vol: 102, page: 2590, stat: Journal Article,

CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
Hudmon, Andy; Schulman, Howard; Kim, James; Maltez, Janet M; Tsien, Richard W; Pitt, Geoffrey S
2005 Nov 7;171(3):537-547, Journal of cell biology
— id: 136741, year: 2005, vol: 171, page: 537, stat: Journal Article,

Adaptation to synaptic inactivity in hippocampal neurons
Thiagarajan, Tara C; Lindskog, Maria; Tsien, Richard W
2005 Sep 1;47(5):725-737, Neuron
— id: 136742, year: 2005, vol: 47, page: 725, stat: Journal Article,

Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy
Cao, Yu-Qing; Piedras-Renteria, Erika S; Smith, Geoffrey B; Chen, Gong; Harata, Nobutoshi C; Tsien, Richard W
2004 Aug 5;43(3):387-400, Neuron
— id: 136745, year: 2004, vol: 43, page: 387, stat: Journal Article,

Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses
Chen, Gong; Harata, Nobutoshi C; Tsien, Richard W
2004 Jan 27;101(4):1063-1068, Proceedings of the National Academy of Sciences of the United States of America
— id: 136747, year: 2004, vol: 101, page: 1063, stat: Journal Article,

Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse
Pagani, R; Song, M; McEnery, M; Qin, N; Tsien, R W; Toro, L; Stefani, E; Uchitel, O D
2004 ;123(1):75-85, Neuroscience
— id: 136749, year: 2004, vol: 123, page: 75, stat: Journal Article,

Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway
Piedras-Renteria, Erika S; Pyle, Jason L; Diehn, Max; Glickfeld, Lindsey L; Harata, Nobutoshi C; Cao, Yuqing; Kavalali, Ege T; Brown, Patrick O; Tsien, Richard W
2004 Mar 9;101(10):3609-3614, Proceedings of the National Academy of Sciences of the United States of America
— id: 136746, year: 2004, vol: 101, page: 3609, stat: Journal Article,

Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium
Smith, Stephen M; Bergsman, Jeremy B; Harata, Nobutoshi C; Scheller, Richard H; Tsien, Richard W
2004 Jan 22;41(2):243-256, Neuron
— id: 136748, year: 2004, vol: 41, page: 243, stat: Journal Article,

Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again
Aravanis, A M; Pyle, J L; Harata, N C; Tsien, R W
2003 Nov;45(6):797-813, Neuropharmacology
— id: 136750, year: 2003, vol: 45, page: 797, stat: Journal Article,

Single synaptic vesicles fusing transiently and successively without loss of identity
Aravanis, A M; Pyle, J L; Tsien, R W
2003 Jun 5;423(6940):643-647, Nature
— id: 136751, year: 2003, vol: 423, page: 643, stat: Journal Article,

Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation
Choi, Sukwoo; Klingauf, Jurgen; Tsien, Richard W
2003 Apr 29;358(1432):695-705, Philosophical transactions of the Royal Society of London. Series B. Biological sciences
— id: 136753, year: 2003, vol: 358, page: 695, stat: Journal Article,

Signaling from synapse to nucleus: the logic behind the mechanisms
Deisseroth, Karl; Mermelstein, Paul G; Xia, Houhui; Tsien, Richard W
2003 Jun;13(3):354-365, Current opinion in neurobiology
— id: 136752, year: 2003, vol: 13, page: 354, stat: Journal Article,

Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels
Urbano, Francisco J; Piedras-Renteria, Erika S; Jun, Kisun; Shin, Hee-Sup; Uchitel, Osvaldo D; Tsien, Richard W
2003 Mar 18;100(6):3491-3496, Proceedings of the National Academy of Sciences of the United States of America
— id: 136754, year: 2003, vol: 100, page: 3491, stat: Journal Article,

Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels
Cataldi, Mauro; Perez-Reyes, Edward; Tsien, Richard W
2002 Nov 29;277(48):45969-45976, Journal of biological chemistry
— id: 136756, year: 2002, vol: 277, page: 45969, stat: Journal Article,

Dynamic multiphosphorylation passwords for activity-dependent gene expression
Deisseroth, Karl; Tsien, Richard W
2002 Apr 11;34(2):179-182, Neuron
— id: 136757, year: 2002, vol: 34, page: 179, stat: Journal Article,

alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength
Thiagarajan, Tara C; Piedras-Renteria, Erika S; Tsien, Richard W
2002 Dec 19;36(6):1103-1114, Neuron
— id: 136755, year: 2002, vol: 36, page: 1103, stat: Journal Article,

Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling
Harata, N; Pyle, J L; Aravanis, A M; Mozhayeva, M; Kavalali, E T; Tsien, R W
2001 Nov;24(11):637-643, Trends in neurosciences
— id: 136760, year: 2001, vol: 24, page: 637, stat: Journal Article,

Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion
Harata, N; Ryan, T A; Smith, S J; Buchanan, J; Tsien, R W
2001 Oct 23;98(22):12748-12753, Proceedings of the National Academy of Sciences of the United States of America
— id: 136761, year: 2001, vol: 98, page: 12748, stat: Journal Article,

Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity
Mermelstein, P G; Deisseroth, K; Dasgupta, N; Isaksen, A L; Tsien, R W
2001 Dec 18;98(26):15342-15347, Proceedings of the National Academy of Sciences of the United States of America
— id: 136758, year: 2001, vol: 98, page: 15342, stat: Journal Article,

Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6
Piedras-Renteria, E S; Watase, K; Harata, N; Zhuchenko, O; Zoghbi, H Y; Lee, C C; Tsien, R W
2001 Dec 1;21(23):9185-9193, Journal of neuroscience
— id: 136759, year: 2001, vol: 21, page: 9185, stat: Journal Article,

Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels
Pitt, G S; Zuhlke, R D; Hudmon, A; Schulman, H; Reuter, H; Tsien, R W
2001 Aug 17;276(33):30794-30802, Journal of biological chemistry
— id: 136762, year: 2001, vol: 276, page: 30794, stat: Journal Article,

Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
Wu, G Y; Deisseroth, K; Tsien, R W
2001 Feb 27;98(5):2808-2813, Proceedings of the National Academy of Sciences of the United States of America
— id: 136763, year: 2001, vol: 98, page: 2808, stat: Journal Article,

Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology
Wu, G Y; Deisseroth, K; Tsien, R W
2001 Feb;4(2):151-158, Nature neuroscience
— id: 136764, year: 2001, vol: 4, page: 151, stat: Journal Article,

Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1
Bergsman, J B; Tsien, R W
2000 Jun 15;20(12):4368-4378, Journal of neuroscience
— id: 136768, year: 2000, vol: 20, page: 4368, stat: Journal Article,

Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating
Bezprozvanny, I; Zhong, P; Scheller, R H; Tsien, R W
2000 Dec 5;97(25):13943-13948, Proceedings of the National Academy of Sciences of the United States of America
— id: 136765, year: 2000, vol: 97, page: 13943, stat: Journal Article,

Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'
Choi, S; Klingauf, J; Tsien, R W
2000 Apr;3(4):330-336, Nature neuroscience
— id: 136770, year: 2000, vol: 3, page: 330, stat: Journal Article,

Syntaxin modulation of slow inactivation of N-type calcium channels
Degtiar, V E; Scheller, R H; Tsien, R W
2000 Jun 15;20(12):4355-4367, Journal of neuroscience
— id: 136769, year: 2000, vol: 20, page: 4355, stat: Journal Article,

Nomenclature of voltage-gated calcium channels
Ertel, E A; Campbell, K P; Harpold, M M; Hofmann, F; Mori, Y; Perez-Reyes, E; Schwartz, A; Snutch, T P; Tanabe, T; Birnbaumer, L; Tsien, R W; Catterall, W A
2000 Mar;25(3):533-535, Neuron
— id: 136771, year: 2000, vol: 25, page: 533, stat: Journal Article,

Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials
Mermelstein, P G; Bito, H; Deisseroth, K; Tsien, R W
2000 Jan 1;20(1):266-273, Journal of neuroscience
— id: 136772, year: 2000, vol: 20, page: 266, stat: Journal Article,

Rapid reuse of readily releasable pool vesicles at hippocampal synapses
Pyle, J L; Kavalali, E T; Piedras-Renteria, E S; Tsien, R W
2000 Oct;28(1):221-231, Neuron
— id: 136766, year: 2000, vol: 28, page: 221, stat: Journal Article,

Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit
Zuhlke, R D; Pitt, G S; Tsien, R W; Reuter, H
2000 Jul 14;275(28):21121-21129, Journal of biological chemistry
— id: 136767, year: 2000, vol: 275, page: 21121, stat: Journal Article,

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
Graef, I A; Mermelstein, P G; Stankunas, K; Neilson, J R; Deisseroth, K; Tsien, R W; Crabtree, G R
1999 Oct 14;401(6754):703-708, Nature
— id: 136776, year: 1999, vol: 401, page: 703, stat: Journal Article,

Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit
Jun, K; Piedras-Renteria, E S; Smith, S M; Wheeler, D B; Lee, S B; Lee, T G; Chin, H; Adams, M E; Scheller, R H; Tsien, R W; Shin, H S
1999 Dec 21;96(26):15245-15250, Proceedings of the National Academy of Sciences of the United States of America
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Activity-dependent regulation of synaptic clustering in a hippocampal culture system
Kavalali, E T; Klingauf, J; Tsien, R W
1999 Oct 26;96(22):12893-12900, Proceedings of the National Academy of Sciences of the United States of America
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Properties of fast endocytosis at hippocampal synapses
Kavalali, E T; Klingauf, J; Tsien, R W
1999 Feb 28;354(1381):337-346, Philosophical transactions of the Royal Society of London. Series B. Biological sciences
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Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices
Liu, G; Choi, S; Tsien, R W
1999 Feb;22(2):395-409, Neuron
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Visualization of synaptic activity in hippocampal slices with FM1-43 enabled by fluorescence quenching
Pyle, J L; Kavalali, E T; Choi, S; Tsien, R W
1999 Dec;24(4):803-808, Neuron
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Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits
Smith, S M; Piedras-Rentera, E S; Namkung, Y; Shin, H S; Tsien, R W
1999 Apr 30;868:175-198, Annals of the New York Academy of Sciences
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Calmodulin supports both inactivation and facilitation of L-type calcium channels
Zuhlke, R D; Pitt, G S; Deisseroth, K; Tsien, R W; Reuter, H
1999 May 13;399(6732):159-162, Nature
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Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
Deisseroth, K; Heist, E K; Tsien, R W
1998 Mar 12;392(6672):198-202, Nature
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Kinetics and regulation of fast endocytosis at hippocampal synapses
Klingauf, J; Kavalali, E T; Tsien, R W
1998 Aug 6;394(6693):581-585, Nature
— id: 136783, year: 1998, vol: 394, page: 581, stat: Journal Article,

Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons
Namkung, Y; Smith, S M; Lee, S B; Skrypnyk, N V; Kim, H L; Chin, H; Scheller, R H; Tsien, R W; Shin, H S
1998 Sep 29;95(20):12010-12015, Proceedings of the National Academy of Sciences of the United States of America
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Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas
Newcomb, R; Szoke, B; Palma, A; Wang, G; Chen, X h; Hopkins, W; Cong, R; Miller, J; Urge, L; Tarczy-Hornoch, K; Loo, J A; Dooley, D J; Nadasdi, L; Tsien, R W; Lemos, J; Miljanich, G
1998 Nov 3;37(44):15353-15362, Biochemistry
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Antisense oligonucleotides against alpha1E reduce R-type calcium currents in cerebellar granule cells
Piedras-Renteria, E S; Tsien, R W
1998 Jun 23;95(13):7760-7765, Proceedings of the National Academy of Sciences of the United States of America
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Molecular physiology. Key clockwork component cloned
Tsien, R W
1998 Feb 26;391(6670):'198'-'202', Nature
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Ca2+-dependent regulation in neuronal gene expression
Bito, H; Deisseroth, K; Tsien, R W
1997 Jun;7(3):419-429, Current opinion in neurobiology
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Aspartate substitutions establish the concerted action of P-region glutamates in repeats I and III in forming the protonation site of L-type Ca2+ channels
Chen, X H; Tsien, R W
1997 Nov 28;272(48):30002-30008, Journal of biological chemistry
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Dendritic Ca2+ channels characterized by recordings from isolated hippocampal dendritic segments
Kavalali, E T; Zhuo, M; Bito, H; Tsien, R W
1997 Apr;18(4):651-663, Neuron
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Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels
Randall, A D; Tsien, R W
1997 Jul;36(7):879-893, Neuropharmacology
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Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels
Stocker, J W; Nadasdi, L; Aldrich, R W; Tsien, R W
1997 May 1;17(9):3002-3013, Journal of neuroscience
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CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression
Bito, H; Deisseroth, K; Tsien, R W
1996 Dec 27;87(7):1203-1214, Cell
— id: 136792, year: 1996, vol: 87, page: 1203, stat: Journal Article,

Molecular basis of proton block of L-type Ca2+ channels
Chen, X H; Bezprozvanny, I; Tsien, R W
1996 Nov;108(5):363-374, Journal of general physiology
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Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity
Deisseroth, K; Bito, H; Tsien, R W
1996 Jan;16(1):89-101, Neuron
— id: 136796, year: 1996, vol: 16, page: 89, stat: Journal Article,

Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus
Wheeler, D B; Randall, A; Tsien, R W
1996 Apr 1;16(7):2226-2237, Journal of neuroscience
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Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins
Zhang, J F; Ellinor, P T; Aldrich, R W; Tsien, R W
1996 Nov;17(5):991-1003, Neuron
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Functional impact of syntaxin on gating of N-type and Q-type calcium channels
Bezprozvanny, I; Scheller, R H; Tsien, R W
1995 Dec 7;378(6557):623-626, Nature
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Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)
Bezprozvanny, I; Tsien, R W
1995 Sep;48(3):540-549, Molecular pharmacology
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Synaptic plasticity: A molecular mechanism for metaplasticity
Deisseroth, K; Bito, H; Schulman, H; Tsien, R W
1995 Dec 1;5(12):1334-1338, Current biology. CB
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Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions
Ellinor, P T; Yang, J; Sather, W A; Zhang, J F; Tsien, R W
1995 Nov;15(5):1121-1132, Neuron
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Properties of synaptic transmission at single hippocampal synaptic boutons
Liu, G; Tsien, R W
1995 Jun 1;375(6530):404-408, Nature
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Synaptic transmission at single visualized hippocampal boutons
Liu, G; Tsien, R W
1995 Nov;34(11):1407-1421, Neuropharmacology
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Presynaptic component of long-term potentiation visualized at individual hippocampal synapses
Malgaroli, A; Ting, A E; Wendland, B; Bergamaschi, A; Villa, A; Tsien, R W; Scheller, R H
1995 Jun 16;268(5217):1624-1628, Science
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Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons
Randall, A; Tsien, R W
1995 Apr;15(4):2995-3012, Journal of neuroscience
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Reflections on Ca(2+)-channel diversity, 1988-1994
Tsien, R W; Lipscombe, D; Madison, D; Bley, K; Fox, A
1995 Feb;18(2):52-54, Trends in neurosciences
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Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS
Wheeler, D B; Randall, A; Sather, W A; Tsien, R W
1995 ;105:65-78, Progress in brain research
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Nitric oxide synthase expression in single hippocampal neurons
Chiang, L W; Schweizer, F E; Tsien, R W; Schulman, H
1994 Nov;27(1):183-188, Brain research. Molecular brain research
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Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin
Ellinor, P T; Zhang, J F; Horne, W A; Tsien, R W
1994 Nov 17;372(6503):272-275, Nature
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An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i
Friel, D D; Tsien, R W
1994 Jul;14(7):4007-4024, Journal of neuroscience
— id: 136812, year: 1994, vol: 14, page: 4007, stat: Journal Article,

Biophysical and pharmacological characterization of a class A calcium channel
Sather, W A; Tanabe, T; Zhang, J F; Tsien, R W
1994 Dec 15;747:294-301, Annals of the New York Academy of Sciences
— id: 136807, year: 1994, vol: 747, page: 294, stat: Journal Article,

Structural basis of ion channel permeation and selectivity
Sather, W A; Yang, J; Tsien, R W
1994 Jun;4(3):313-323, Current opinion in neurobiology
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Existence of nitric oxide synthase in rat hippocampal pyramidal cells
Wendland, B; Schweizer, F E; Ryan, T A; Nakane, M; Murad, F; Scheller, R H; Tsien, R W
1994 Mar 15;91(6):2151-2155, Proceedings of the National Academy of Sciences of the United States of America
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Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission
Wheeler, D B; Randall, A; Tsien, R W
1994 Apr 1;264(5155):107-111, Science
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Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system
Wheeler, D B; Sather, W A; Randall, A; Tsien, R W
1994 ;29:155-171, Advances in second messenger & phosphoprotein research
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Response
Wheeler, D B; Tsien, R W; Randall, A
1994 Nov 4;266(5186):830-831, Science
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Molecular determinants of voltage-dependent inactivation in calcium channels
Zhang, J F; Ellinor, P T; Aldrich, R W; Tsien, R W
1994 Nov 3;372(6501):97-100, Nature
— id: 136810, year: 1994, vol: 372, page: 97, stat: Journal Article,

Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics
Delcour, A H; Lipscombe, D; Tsien, R W
1993 Jan;13(1):181-194, Journal of neuroscience
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Altered prevalence of gating modes in neurotransmitter inhibition of N-type calcium channels
Delcour, A H; Tsien, R W
1993 Feb 12;259(5097):980-984, Science
— id: 136823, year: 1993, vol: 259, page: 980, stat: Journal Article,

Functional expression of a rapidly inactivating neuronal calcium channel
Ellinor, P T; Zhang, J F; Randall, A D; Zhou, M; Schwarz, T L; Tsien, R W; Horne, W A
1993 Jun 3;363(6428):455-458, Nature
— id: 136821, year: 1993, vol: 363, page: 455, stat: Journal Article,

Molecular diversity of Ca2+ channel alpha 1 subunits from the marine ray Discopyge ommata
Horne, W A; Ellinor, P T; Inman, I; Zhou, M; Tsien, R W; Schwarz, T L
1993 May 1;90(9):3787-3791, Proceedings of the National Academy of Sciences of the United States of America
— id: 136822, year: 1993, vol: 90, page: 3787, stat: Journal Article,

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons
Ryan, T A; Reuter, H; Wendland, B; Schweizer, F E; Tsien, R W; Smith, S J
1993 Oct;11(4):713-724, Neuron
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Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits
Sather, W A; Tanabe, T; Zhang, J F; Mori, Y; Adams, M E; Tsien, R W
1993 Aug;11(2):291-303, Neuron
— id: 136820, year: 1993, vol: 11, page: 291, stat: Journal Article,

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels
Yang, J; Ellinor, P T; Sather, W A; Zhang, J F; Tsien, R W
1993 Nov 11;366(6451):158-161, Nature
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Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons
Yang, J; Tsien, R W
1993 Feb;10(2):127-136, Neuron
— id: 136824, year: 1993, vol: 10, page: 127, stat: Journal Article,

Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons
Zhang, J F; Randall, A D; Ellinor, P T; Horne, W A; Sather, W A; Tanabe, T; Schwarz, T L; Tsien, R W
1993 Nov;32(11):1075-1088, Neuropharmacology
— id: 136818, year: 1993, vol: 32, page: 1075, stat: Journal Article,

A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i
Friel, D D; Tsien, R W
1992 May;450:217-246, Journal of physiology
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Phase-dependent contributions from Ca2+ entry and Ca2+ release to caffeine-induced [Ca2+]i oscillations in bullfrog sympathetic neurons
Friel, D D; Tsien, R W
1992 Jun;8(6):1109-1125, Neuron
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Persistent signalling and changes in presynaptic function in long-term potentiation
Malgaroli, A; Malinow, R; Schulman, H; Tsien, R W
1992 ;164:176-91; discussion 192, CIBA Foundation symposium
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Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons
Malgaroli, A; Tsien, R W
1992 May 14;357(6374):134-139, Nature
— id: 136827, year: 1992, vol: 357, page: 134, stat: Journal Article,

Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels
Cline, H T; Tsien, R W
1991 Feb;6(2):259-267, Neuron
— id: 136832, year: 1991, vol: 6, page: 259, stat: Journal Article,

omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor
Horne, W A; Hawrot, E; Tsien, R W
1991 Jul 25;266(21):13719-13725, Journal of biological chemistry
— id: 136831, year: 1991, vol: 266, page: 13719, stat: Journal Article,

Long-term potentiation: postsynaptic activation of Ca(2+)-dependent protein kinases with subsequent presynaptic enhancement
Malinow, R; Tsien, R W
1991 ;89:271-289, Progress in brain research
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Molecular diversity of voltage-dependent Ca2+ channels
Tsien, R W; Ellinor, P T; Horne, W A
1991 Sep;12(9):349-354, Trends in pharmacological science
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Changes in presynaptic function during long-term potentiation
Tsien, R W; Malinow, R
1991 ;635:208-220, Annals of the New York Academy of Sciences
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Inhibition of Ca2+ and K+ channels in sympathetic neurons by neuropeptides and other ganglionic transmitters
Bley, K R; Tsien, R W
1990 Mar;4(3):379-391, Neuron
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Identifying and localizing protein kinases necessary for LTP
Malinow, R; Tsien, R W
1990 ;268:301-305, Advances in experimental medicine & biology
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Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices
Malinow, R; Tsien, R W
1990 Jul 12;346(6280):177-180, Nature
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Long-term potentiation: presynaptic enhancement following postsynaptic activation of Ca(++)-dependent protein kinases
Tsien, R W; Malinow, R
1990 ;55:147-159, Cold Spring Harbor symposia on quantitative biology
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Peptide inhibitors of PKC and CaMK block induction but not expression of long-term potentiation
Tsien, R W; Schulman, H; Malinow, R
1990 ;24:101-107, Advances in second messenger & phosphoprotein research
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Calcium channels, stores, and oscillations
Tsien, R W; Tsien, R Y
1990 ;6:715-760, Annual review of cell biology
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Voltage-gated calcium channels: direct observation of the anomalous mole fraction effect at the single-channel level
Friel, D D; Tsien, R W
1989 Jul;86(13):5207-5211, Proceedings of the National Academy of Sciences of the United States of America
— id: 136843, year: 1989, vol: 86, page: 5207, stat: Journal Article,

The N-type Ca channel in frog sympathetic neurons and its role in alpha-adrenergic modulation of transmitter release
Kongsamut, S; Lipscombe, D; Tsien, R W
1989 ;560:312-333, Annals of the New York Academy of Sciences
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Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating
Lipscombe, D; Kongsamut, S; Tsien, R W
1989 Aug 24;340(6235):639-642, Nature
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Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP
Malinow, R; Schulman, H; Tsien, R W
1989 Aug 25;245(4920):862-866, Science
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Solubilization, partial purification, and properties of omega-conotoxin receptors associated with voltage-dependent calcium channels from rat brain synaptosomes
Rosenberg, R L; Isaacson, J S; Tsien, R W
1989 ;560:39-52, Annals of the New York Academy of Sciences
— id: 136845, year: 1989, vol: 560, page: 39, stat: Journal Article,

Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery
Benham, C D; Tsien, R W
1988 Oct;404:767-784, Journal of physiology
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Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons
Hirning, L D; Fox, A P; McCleskey, E W; Olivera, B M; Thayer, S A; Miller, R J; Tsien, R W
1988 Jan 1;239(4835):57-61, Science
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Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons
Lipscombe, D; Madison, D V; Poenie, M; Reuter, H; Tsien, R W; Tsien, R Y
1988 Jul;1(5):355-365, Neuron
— id: 136850, year: 1988, vol: 1, page: 355, stat: Journal Article,

Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons
Lipscombe, D; Madison, D V; Poenie, M; Reuter, H; Tsien, R Y; Tsien, R W
1988 Apr;85(7):2398-2402, Proceedings of the National Academy of Sciences of the United States of America
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Persistent protein kinase activity underlying long-term potentiation
Malinow, R; Madison, D V; Tsien, R W
1988 Oct 27;335(6193):820-824, Nature
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The effect of calcium channel antagonists on peripheral neurones
Miller, R J; Ewald, D A; Fox, A P; Hirning, L D; McCleskey, E W; Perney, T M; Sturek, M; Thayer, S A; Tsien, R W; Walker, M W
1988 ;522:269-277, Annals of the New York Academy of Sciences
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Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials
Rosenberg, R L; Hess, P; Tsien, R W
1988 Jul;92(1):27-54, Journal of general physiology
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Multiple types of neuronal calcium channels and their selective modulation
Tsien, R W; Lipscombe, D; Madison, D V; Bley, K R; Fox, A P
1988 Oct;11(10):431-438, Trends in neurosciences
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Two types of calcium channels in single smooth muscle cells from rabbit ear artery studied with whole-cell and single-channel recordings
Benham, C D; Hess, P; Tsien, R W
1987 Oct;61(4 Pt 2):I10-I16, Circulation research
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A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle
Benham, C D; Tsien, R W
1987 Jul 16-22;328(6127):275-278, Nature
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Calcium-permeable channels in vascular smooth muscle: voltage-activated, receptor-operated, and leak channels
Benham, C D; Tsien, R W
1987 ;42:45-64, Society of General Physiologists series
— id: 136863, year: 1987, vol: 42, page: 45, stat: Journal Article,

Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones
Fox, A P; Nowycky, M C; Tsien, R W
1987 Dec;394:149-172, Journal of physiology
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Single-channel recordings of three types of calcium channels in chick sensory neurones
Fox, A P; Nowycky, M C; Tsien, R W
1987 Dec;394:173-200, Journal of physiology
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Isolated muscle cells as a physiological model
Lieberman, M; Hauschka, S D; Hall, Z W; Eisenberg, B R; Horn, R; Walsh, J V; Tsien, R W; Jones, A W; Walker, J L; Poenie, M
1987 Sep;253(3 Pt 1):C349-C363, American journal of physiology
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Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle
McCleskey, E W; Fox, A P; Feldman, D H; Cruz, L J; Olivera, B M; Tsien, R W; Yoshikami, D
1987 Jun;84(12):4327-4331, Proceedings of the National Academy of Sciences of the United States of America
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Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons
Strong, J A; Fox, A P; Tsien, R W; Kaczmarek, L K
1987 Feb 19-25;325(6106):714-717, Nature
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Multiple types of calcium channel in excitable cells
Tsien, R W; Fox, A P; Hess, P; McCleskey, E W; Nilius, B; Nowycky, M C; Rosenberg, R L
1987 ;41:167-187, Society of General Physiologists series
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Calcium channels: mechanisms of selectivity, permeation, and block
Tsien, R W; Hess, P; McCleskey, E W; Rosenberg, R L
1987 ;16:265-290, Annual review of biophysics & biophysical chemistry
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Cardiac calcium currents at the level of single channels
Tsien, R W; Nilius, B
1987 Dec 1;43(11-12):1169-1172, Experientia
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Calcium channel types in cardiac myocytes: modulation by dihydropyridines and beta-adrenergic stimulation
Hess, P; Lansman, J B; Nilius, B; Tsien, R W
1986 ;8 Suppl 9:S11-S21, Journal of cardiovascular pharmacology
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Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells
Hess, P; Lansman, J B; Tsien, R W
1986 Sep;88(3):293-319, Journal of general physiology
— id: 136867, year: 1986, vol: 88, page: 293, stat: Journal Article,

Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore
Lansman, J B; Hess, P; Tsien, R W
1986 Sep;88(3):321-347, Journal of general physiology
— id: 136866, year: 1986, vol: 88, page: 321, stat: Journal Article,

Different types of calcium channels
McCleskey, E W; Fox, A P; Feldman, D; Tsien, R W
1986 Sep;124:177-190, Journal of experimental biology
— id: 136865, year: 1986, vol: 124, page: 177, stat: Journal Article,

A novel type of cardiac calcium channel in ventricular cells
Nilius, B; Hess, P; Lansman, J B; Tsien, R W
1986 ;45(1-2):S167-S170, Biomedica biochimica acta
— id: 136870, year: 1986, vol: 45, page: S167, stat: Journal Article,

Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating
Rosenberg, R L; Hess, P; Reeves, J P; Smilowitz, H; Tsien, R W
1986 Mar 28;231(4745):1564-1566, Science
— id: 136869, year: 1986, vol: 231, page: 1564, stat: Journal Article,

Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists
Tsien, R W; Bean, B P; Hess, P; Lansman, J B; Nilius, B; Nowycky, M C
1986 Jul;18(7):691-710, Journal of molecular & cellular cardiology
— id: 136868, year: 1986, vol: 18, page: 691, stat: Journal Article,

Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium
Lee, K S; Marban, E; Tsien, R W
1985 Jul;364:395-411, Journal of physiology
— id: 136874, year: 1985, vol: 364, page: 395, stat: Journal Article,

A novel type of cardiac calcium channel in ventricular cells
Nilius, B; Hess, P; Lansman, J B; Tsien, R W
1985 Aug 1-7;316(6027):443-446, Nature
— id: 136872, year: 1985, vol: 316, page: 443, stat: Journal Article,

Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644
Nowycky, M C; Fox, A P; Tsien, R W
1985 Apr;82(7):2178-2182, Proceedings of the National Academy of Sciences of the United States of America
— id: 136875, year: 1985, vol: 82, page: 2178, stat: Journal Article,

Three types of neuronal calcium channel with different calcium agonist sensitivity
Nowycky, M C; Fox, A P; Tsien, R W
1985 Aug 1-7;316(6027):440-443, Nature
— id: 136873, year: 1985, vol: 316, page: 440, stat: Journal Article,

Beta-adrenergic modulation of calcium channels in frog ventricular heart cells
Bean, B P; Nowycky, M C; Tsien, R W
1984 Jan 26-Feb 1;307(5949):371-375, Nature
— id: 136880, year: 1984, vol: 307, page: 371, stat: Journal Article,

Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers
Cohen, C J; Bean, B P; Tsien, R W
1984 Jun;54(6):636-651, Circulation research
— id: 136878, year: 1984, vol: 54, page: 636, stat: Journal Article,

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
Hess, P; Lansman, J B; Tsien, R W
1984 Oct 11-17;311(5986):538-544, Nature
— id: 136876, year: 1984, vol: 311, page: 538, stat: Journal Article,

Mechanism of ion permeation through calcium channels
Hess, P; Tsien, R W
1984 May 31-Jun 6;309(5967):453-456, Nature
— id: 136879, year: 1984, vol: 309, page: 453, stat: Journal Article,

High selectivity of calcium channels in single dialysed heart cells of the guinea-pig
Lee, K S; Tsien, R W
1984 Sep;354:253-272, Journal of physiology
— id: 136877, year: 1984, vol: 354, page: 253, stat: Journal Article,

Lidocaine block of cardiac sodium channels
Bean, B P; Cohen, C J; Tsien, R W
1983 May;81(5):613-642, Journal of general physiology
— id: 136881, year: 1983, vol: 81, page: 613, stat: Journal Article,

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells
Lee, K S; Tsien, R W
1983 Apr 28;302(5911):790-794, Nature
— id: 136882, year: 1983, vol: 302, page: 790, stat: Journal Article,

Calcium channels in excitable cell membranes
Tsien, R W
1983 ;45:341-358, Annual review of physiology
— id: 136883, year: 1983, vol: 45, page: 341, stat: Journal Article,

Calcium channels: mechanisms of beta-adrenergic modulation and ion permeation
Tsien, R W; Bean, B P; Hess, P; Nowycky, M
1983 ;48 Pt 1:201-212, Cold Spring Harbor symposia on quantitative biology
— id: 136884, year: 1983, vol: 48 Pt 1, page: 201, stat: Journal Article,

Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers
Kass, R S; Tsien, R W
1982 Jun;38(3):259-269, Biophysical journal
— id: 136889, year: 1982, vol: 38, page: 259, stat: Journal Article,

Reversal of current through calcium channels in dialysed single heart cells
Lee, K S; Tsien, R W
1982 Jun 10;297(5866):498-501, Nature
— id: 136888, year: 1982, vol: 297, page: 498, stat: Journal Article,

Effects of nystatin-mediated intracellular ion substitution on membrane currents in calf purkinje fibres
Marban, E; Tsien, R W
1982 Aug;329:569-587, Journal of physiology
— id: 136886, year: 1982, vol: 329, page: 569, stat: Journal Article,

Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium?
Marban, E; Tsien, R W
1982 Aug;329:589-614, Journal of physiology
— id: 136885, year: 1982, vol: 329, page: 589, stat: Journal Article,

Properties of single calcium channels in cardiac cell culture
Reuter, H; Stevens, C F; Tsien, R W; Yellen, G
1982 Jun 10;297(5866):501-504, Nature
— id: 136887, year: 1982, vol: 297, page: 501, stat: Journal Article,

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating
Cohen, C J; Bean, B P; Colatsky, T J; Tsien, R W
1981 Oct;78(4):383-411, Journal of general physiology
— id: 136890, year: 1981, vol: 78, page: 383, stat: Journal Article,

Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes
Marban, E; Rink, T J; Tsien, R W; Tsien, R Y
1980 Aug 28;286(5776):845-850, Nature
— id: 136891, year: 1980, vol: 286, page: 845, stat: Journal Article,

Calcium-activated transient outward current in calf cardiac Purkinje fibres
Siegelbaum, S A; Tsien, R W
1980 Feb;299:485-506, Journal of physiology
— id: 136892, year: 1980, vol: 299, page: 485, stat: Journal Article,

Tetrodotoxin block of cardiac sodium channels during repetitive or steady depolarizations in the rabbit [proceedings]
Cohen, C J; Colatsky, T J; Tsien, R W
1979 Nov;296:70P-71P, Journal of physiology
— id: 136893, year: 1979, vol: 296, page: 70P, stat: Journal Article,

Sodium channels in rabbit cardiac Purkinje fibres
Colatsky, J J; Tsien, R W
1979 Mar 15;278(5701):265-268, Nature
— id: 136898, year: 1979, vol: 278, page: 265, stat: Journal Article,

Electrical properties associated with wide intercellular clefts in rabbit Purkinje fibres
Colatsky, T J; Tsien, R W
1979 May;290(2):227-252, Journal of physiology
— id: 136896, year: 1979, vol: 290, page: 227, stat: Journal Article,

Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured?
Kass, R S; Siegelbaum, S A; Tsien, R W
1979 May;290(2):201-225, Journal of physiology
— id: 136897, year: 1979, vol: 290, page: 201, stat: Journal Article,

Ouabain increases the slow inward calcium current in ventricular muscle of the ferret [proceedings]
Marban, E; Tsien, R W
1979 Jul;292:72P-73P, Journal of physiology
— id: 136895, year: 1979, vol: 292, page: 72P, stat: Journal Article,

Calcium-activated transient outward current in cardiac Purkinje fibres [proceedings]
Siegelbaum, S A; Tsien, R W
1979 Feb;287:36P-37P, Journal of physiology
— id: 136899, year: 1979, vol: 287, page: 36P, stat: Journal Article,

Cellular and subcellular mechanisms of cardiac pacemaker oscillations
Tsien, R W; Kass, R S; Weingart, R
1979 Aug;81:205-215, Journal of experimental biology
— id: 136894, year: 1979, vol: 81, page: 205, stat: Journal Article,

Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres
Kass, R S; Lederer, W J; Tsien, R W; Weingart, R
1978 Aug;281:187-208, Journal of physiology
— id: 136901, year: 1978, vol: 281, page: 187, stat: Journal Article,

Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres
Kass, R S; Tsien, R W; Weingart, R
1978 Aug;281:209-226, Journal of physiology
— id: 136900, year: 1978, vol: 281, page: 209, stat: Journal Article,

Ionic mechanisms of pacemaker activity in cardiac Purkinje fibers
Tsien, R W; Carpenter, D O
1978 Jun;37(8):2127-2131, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 136902, year: 1978, vol: 37, page: 2127, stat: Journal Article,

Calcium ions and membrane current changes induced by digitals in cardiac Purkinje fibers
Tsien, R W; Kass, R S; Weingart, R
1978 Apr 28;307:483-490, Annals of the New York Academy of Sciences
— id: 136904, year: 1978, vol: 307, page: 483, stat: Journal Article,

Is digitalis inotropy associated with enhanced slow inward calcium current?
Weingart, R; Kass, R S; Tsien, R W
1978 Jun 1;273(5661):389-392, Nature
— id: 136903, year: 1978, vol: 273, page: 389, stat: Journal Article,

Role of intracellular calcium in the transient outward current of calf Purkinje fibres
Siegelbaum, S A; Tsien, R W; Kass, R S
1977 Oct 13;269(5629):611-613, Nature
— id: 136905, year: 1977, vol: 269, page: 611, stat: Journal Article,

Cyclic AMP and contractile activity in heart
Tsien, R W
1977 ;8:363-420, Advances in cyclic nucleotide research
— id: 136906, year: 1977, vol: 8, page: 363, stat: Journal Article,

Incomplete inactivation of the slow inward current in cardiac Purkinje fibres [proceedings]
Kass, R S; Siegelbaum, S; Tsien, R W
1976 Dec;263(1):127P-128P, Journal of physiology
— id: 136908, year: 1976, vol: 263, page: 127P, stat: Journal Article,

Control of action potential duration by calcium ions in cardiac Purkinje fibers
Kass, R S; Tsien, R W
1976 May;67(5):599-617, Journal of general physiology
— id: 136910, year: 1976, vol: 67, page: 599, stat: Journal Article,

Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres
Lederer, W J; Tsien, R W
1976 Dec;263(2):73-100, Journal of physiology
— id: 136907, year: 1976, vol: 263, page: 73, stat: Journal Article,

Possible effects of hydrogen ions in ischemic myocardium
Tsien, R W
1976 Mar;53(3 Suppl):I14-I16, Circulation
— id: 136911, year: 1976, vol: 53, page: I14, stat: Journal Article,

Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method
Tsien, R W; Weingart, R
1976 Aug;260(1):117-141, Journal of physiology
— id: 136909, year: 1976, vol: 260, page: 117, stat: Journal Article,

Effects of acetylcholine on membrane currents in frog artrial muscle
Giles, W; Tsien, R W
1975 Mar;246(2):64P-66P, Journal of physiology
— id: 136915, year: 1975, vol: 246, page: 64P, stat: Journal Article,

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers
Kass, R S; Tsien, R W
1975 Aug;66(2):169-192, Journal of general physiology
— id: 136913, year: 1975, vol: 66, page: 169, stat: Journal Article,

Proceedings: Transient inward current underlying strophanthidin's enhancement of pace-maker activity in Purkinje fibres
Lederer, W J; Tsien, R W
1975 Jul;249(1):40P-41P, Journal of physiology
— id: 136914, year: 1975, vol: 249, page: 40P, stat: Journal Article,

Reconstruction of the electrical activity of cardiac Purkinje fibres
McAllister, R E; Noble, D; Tsien, R W
1975 Sep;251(1):1-59, Journal of physiology
— id: 136912, year: 1975, vol: 251, page: 1, stat: Journal Article,

Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers
Tsien, R W
1974 Sep;64(3):293-319, Journal of general physiology
— id: 136917, year: 1974, vol: 64, page: 293, stat: Journal Article,

Mode of action of chronotropic agents in cardiac Purkinje fibers. Does epinephrine act by directly modifying the external surface charge?
Tsien, R W
1974 Sep;64(3):320-342, Journal of general physiology
— id: 136918, year: 1974, vol: 64, page: 320, stat: Journal Article,

Proceedings: Cyclic AMP: cell-to-cell movement and inotropic effect in ventricular muscle, studied by a cut-end method
Tsien, R W; Weingart, R
1974 Oct;242(2):95P-96P, Journal of physiology
— id: 136916, year: 1974, vol: 242, page: 95P, stat: Journal Article,

Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres
Tsien, R W
1973 Sep 26;245(143):120-122, Nature: new biology
— id: 136920, year: 1973, vol: 245, page: 120, stat: Journal Article,

Control of conductance in cardiac membrane permeability
Tsien, R W
1973 Jun;11(3):204-210, Neurosciences research program bulletin
— id: 136921, year: 1973, vol: 11, page: 204, stat: Journal Article,

Proceedings: Does adrenaline act by directly modifying the external membrane surface charge of cardiac Purkinje fibres?
Tsien, R W
1973 Oct;234(2):37P-39P, Journal of physiology
— id: 136919, year: 1973, vol: 234, page: 37P, stat: Journal Article,

Separation of the pace-maker and plateau components of delayed rectification in cardiac Purkinje fibres
Hauswirth, O; Noble, D; Tsien, R W
1972 Aug;225(1):211-235, Journal of physiology
— id: 136923, year: 1972, vol: 225, page: 211, stat: Journal Article,

The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials
Hausworth, O; Noble, D; Tsien, R W
1972 Apr;222(1):27-49, Journal of physiology
— id: 136924, year: 1972, vol: 222, page: 27, stat: Journal Article,

Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres
Tsien, R W; Giles, W; Greengard, P
1972 Dec 6;240(101):181-183, Nature: new biology
— id: 136922, year: 1972, vol: 240, page: 181, stat: Journal Article,

Reconstruction of the actions of adrenaline and calcium on cardiac pacemaker potentials
Hauswirth, O; McAllister, R E; Noble, D; Tsien, R W
1969 Oct;204(2):126P+-126P+, Journal of physiology
— id: 136925, year: 1969, vol: 204, page: 126P+, stat: Journal Article,

The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres
Hauswirth, O; Noble, D; Tsien, R W
1969 Jan;200(1):255-265, Journal of physiology
— id: 136926, year: 1969, vol: 200, page: 255, stat: Journal Article,

Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres
Noble, D; Tsien, R W
1969 Jan;200(1):205-231, Journal of physiology
— id: 136928, year: 1969, vol: 200, page: 205, stat: Journal Article,

Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current
Noble, D; Tsien, R W
1969 Jan;200(1):233-254, Journal of physiology
— id: 136927, year: 1969, vol: 200, page: 233, stat: Journal Article,

Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers
Hauswirth, O; Noble, D; Tsien, R W
1968 Nov 22;162(856):916-917, Science
— id: 136929, year: 1968, vol: 162, page: 916, stat: Journal Article,

Kinetics of slow component of potassium current in cardiac purkinje fibres
Noble, D; Tsien, R W
1968 Jan;194(1):31P-32P, Journal of physiology
— id: 136931, year: 1968, vol: 194, page: 31P, stat: Journal Article,

The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres
Noble, D; Tsien, R W
1968 Mar;195(1):185-214, Journal of physiology
— id: 136930, year: 1968, vol: 195, page: 185, stat: Journal Article,