Angel G Pellicer

Biosketch / Results /

Angel Pellicer

Research Professor, Department of Pathology
Pathology

Contact Info

Address
550 First Avenue
New York, NY 10016

212/263-8547
Angel.Pellicer@nyumc.org

Education

— . In 1976 he obtained a PhD in Biochemistry from University of Madrid, Graduate Education
1976 — Dr. Pellicer did a residency in Internal Medicine at Central Army Hospital. He was a Postdoctoral fellow at the Institute of Cancer Research, Columbia University, Residency

Research Summary

Our laboratory investigates the mechanisms of oncogene activation, tumor suppressor gene inactivation and the function that these genes have in malignant transformation and normal cellular processes. Specifically, we study the ras family genes, which are activated in a significant percentage of human tumors. Working with animal model systems, we have induced several types of tumors and analyzed them at the molecular level. To determine the exact role of the N-ras oncogene in these tumors, we constructed several lines of transgenic mice that develop different types of neoplasias, mimicking the phenotype of the tumors from where the oncogene was originally isolated. Moreover, with mutant mice lacking the N-ras gene (knockout) we are determining the cellular pathways in which this gene is specifically involved.

In addition, we are characterizing a new oncogene identified in the laboratory, rsc, that is a homologue of the activator for another member of the ras extended gene family, Ral, and we are continuing our studies on the mechanisms of inactivation of p15 in murine thymic lymphomas.

Research Interests

Oncogenes and Tumor Suppressor Genes Their Role in Tumorigenesis

The differential palmitoylation States of N-ras and h-ras determine their distinct Golgi subcompartment localizations
Lynch, Stephen J; Snitkin, Harriet; Gumper, Iwona; Philips, Mark R; Sabatini, David; Pellicer, Angel
2014-12-01; 0021-9541,Journal of cellular physiology - id: 1360222, year: 2015 Journal Article

Correction: In TCR-Stimulated T-cells, N-ras Regulates Specific Genes and Signal Transduction Pathways
Lynch, Stephen J; Zavadil, Jiri; Pellicer, Angel
2014-01-27; 1932-6203,PLoS one - id: 761372, year: 2013 PUBLISHED ERRATUM

In TCR-Stimulated T-cells, N-ras Regulates Specific Genes and Signal Transduction Pathways
Lynch, Stephen J; Zavadil, Jiri; Pellicer, Angel
2013-06-24; 1932-6203,PLoS one - id: 394082, year: 2013 Journal Article

Wild type N-ras displays anti-malignant properties, in part by downregulating decorin
Benet M; Dulman RY; Suzme R; de Miera EV; Vega ME; Nguyen T; Zavadil J; Pellicer A
2012-02-05; 1097-4652,Journal of cellular physiology - id: 137054, year: 2012

p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis
Osei-Sarfo, Kwame; Perez de Castro, Ignacio; Pellicer, Angel
2012-03-05; 0143-3334,Carcinogenesis - id: 158582, year: 2012 Journal Article