Michele Pagano

Biosketch / Results /

Michele Pagano

May Ellen and Gerald Jay Ritter Professor of Oncology, Department of Biochemistry and Molecular Pharmacology
Chair, Department of Biochemistry and Molecular Pharmacology

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-5129
Michele.Pagano@nyumc.org


Education

— First Medical School University of Naples, Italy, Medical Education

Research Summary

Our laboratory explores the roles that the ubiquitin system plays in fundamental cellular processes, such as cell growth, proliferation, and the DNA damage response. Our group is also committed to understanding how the deregulation of this regulatory network contributes to malignant transformation. 

Research Interests

Cell Cycle Control and Ubiquitin-mediated degradation

Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2
Dankert, John F; Rona, Gergely; Clijsters, Linda; Geter, Phillip; Skaar, Jeffrey R; Bermudez-Hernandez, Keria; Sassani, Elizabeth; Fenyo, David; Ueberheide, Beatrix; Schneider, Robert; Pagano, Michele. Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Molecular cell. 2016 Oct 20;64(3):507-519 (2288562)

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer
Duan, Shanshan; Pagano, Michele. SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer. Molecular cell. 2015 Sep 17;59(6):883-884 (1779442)

The Integrator complex controls the termination of transcription at diverse classes of gene targets
Skaar, Jeffrey R; Ferris, Andrea L; Wu, Xiaolin; Saraf, Anita; Khanna, Kum Kum; Florens, Laurence; Washburn, Michael P; Hughes, Stephen H; Pagano, Michele. The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell research. 2015 Feb 13;25(3):288-305 (1481242)

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response
Young, Lauren M; Marzio, Antonio; Perez-Duran, Pablo; Reid, Dylan A; Meredith, Daniel N; Roberti, Domenico; Star, Ayelet; Rothenberg, Eli; Ueberheide, Beatrix; Pagano, Michele. TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response. Cell reports. 2015 Oct 8;13(3):451-459 (1803582)

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival
Chen, X; Sahasrabuddhe, A A; Szankasi, P; Chung, F; Basrur, V; Rangnekar, V M; Pagano, M; Lim, M S; Elenitoba-Johnson, K S J. Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival. Cell death & differentiation. 2014 Jul 4;21(10):1535-1545 (1186632)