Michele Pagano

Biosketch / Results /

Michele Pagano

May Ellen and Gerald Jay Ritter Professor of Oncology, Department of Pathology
Perlmutter Cancer Center

Contact Info

522 First Avenue
New York, NY 10016



— Dr. Pagano was a post-doctoral fellow at EMBL, Heidelberg, Germany (August 1990-October 1992), before following his mentor to Mitotix Inc, Cambridge, MA (November 1992-August 1996), PostDoctoral Training
— First Medical School University of Naples, Italy, Medical Education

Research Summary

Our laboratory explores the roles that the ubiquitin system plays in fundamental cellualr processes, such as cell growth, proliferation, and the DNA damage response. His group is also committed to understanding how the deregulation of this regulatory network contributes to malignant transformation. .

Research Interests

Cell Cycle Control and Ubiquitin-mediated degradation

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing
Pagan, Julia K; Marzio, Antonio; Jones, Mathew J K; Saraf, Anita; Jallepalli, Prasad V; Florens, Laurence; Washburn, Michael P; Pagano, Michele
2015-01-22; 1465-7392,Nature cell biology - id: 1437062, year: 2015 Journal Article

The Integrator complex controls the termination of transcription at diverse classes of gene targets
Skaar, Jeffrey R; Ferris, Andrea L; Wu, Xiaolin; Saraf, Anita; Khanna, Kum Kum; Florens, Laurence; Washburn, Michael P; Hughes, Stephen H; Pagano, Michele
2015-03-09; 1001-0602,Cell research - id: 1481242, year: 2015 Journal Article

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival
Chen, X; Sahasrabuddhe, A A; Szankasi, P; Chung, F; Basrur, V; Rangnekar, V M; Pagano, M; Lim, M S; Elenitoba-Johnson, K S J
2014-09-15; 1350-9047,Cell death & differentiation - id: 1186632, year: 2014 Journal Article

Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle
Choi, B H; Pagano, M; Da, W
2014-07-02; 0021-9258,Journal of biological chemistry - id: 1058172, year: 2014

Cdh1, a substrate recruiting component of APC/C ubiquitin E3 ligase, specifically interacts with PTEN and promotes its removal from chromatin
Choi, Byeong Hyeok; Pagano, Michele; Huang, Chuanshu; Dai, Wei
2014-05-14; 0021-9258,Journal of biological chemistry - id: 988602, year: 2014 JOURNAL ARTICLE