Dmitry Novikov

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Dmitry Novikov

Associate Professor, Department of Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212/263-2718
Dmitry.Novikov@nyumc.org


Research Summary

I bring the wealth of modern analytical tools from theoretical physics in order to quantify and interpret a variety of MRI modalities in terms of tissue structure below the nominal imaging resolution. I focus on MRI measurements of diffusion, transverse relaxation and perfusion, in order to quantify biophysical parameters such as cell structure and size, membrane permeability, amount of accumulated iron, etc, and to identify quantitative disease biomarkers in neurodegenerative diseases, tumors and myopathies. 

Research Interests

Mapping of tissue microstructure using diffusion and transverse relaxation MRI combined with biophysical modeling

In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter
Fieremans, Els; Burcaw, Lauren M; Lee, Hong-Hsi; Lemberskiy, Gregory; Veraart, Jelle; Novikov, Dmitry S. In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter. Neuroimage. 2016 Jan 20;129:414-427 (1929552)

In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy
Jelescu, Ileana O; Zurek, Magdalena; Winters, Kerryanne V; Veraart, Jelle; Rajaratnam, Anjali; Kim, Nathanael S; Babb, James S; Shepherd, Timothy M; Novikov, Dmitry S; Kim, Sungheon G; Fieremans, Els. In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy. Neuroimage. 2016 Feb 11;132:104-114 (1949552)

Mesoscopic structure of neuronal tracts from time-dependent diffusion
Burcaw, Lauren M; Fieremans, Els; Novikov, Dmitry S. Mesoscopic structure of neuronal tracts from time-dependent diffusion. Neuroimage. 2015 Mar 30;114:18-37 e1004789 (1519702)

N-acetyl-aspartate levels correlate with intra-axonal compartment parameters from diffusion MRI
Grossman, Elan J; Kirov, Ivan I; Gonen, Oded; Novikov, Dmitry S; Davitz, Matthew S; Lui, Yvonne W; Grossman, Robert I; Inglese, Matilde; Fieremans, Els. N-acetyl-aspartate levels correlate with intra-axonal compartment parameters from diffusion MRI. Neuroimage. 2015 May;118:334-343 (1615472)

Degeneracy in model parameter estimation for multi-compartmental diffusion in neuronal tissue
Jelescu, Ileana O; Veraart, Jelle; Fieremans, Els; Novikov, Dmitry S. Degeneracy in model parameter estimation for multi-compartmental diffusion in neuronal tissue. NMR in biomedicine. 2015 Nov 29;29(1):33-47 (1863192)