Richard P. Novick

Biosketch / Results /

Richard P. Novick, M.D.

Professor; Recanati Family Professor of Science;
Departments of Microbiology (Skirball), Medicine (Pulmy&CCM Div) and Molecular Pathogenesis

Contact Info

Address
540 First Avenue
Floor 2 Room Admin.
Skirball Institute
New York, NY 10016

212-263-6290, 212-263-6294
212-263-5711
Richard.Novick@med.nyu.edu

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Education

1962-1963 — Department of Medicine, Vanderbilt University Hospital, Residency
— Dr. Novick was a Postdoctoral Fellow at the National Institute for Medical Research in London, England, 1961-1962. He was a Special Postdoctoral Fellow at The Rockefeller University, New York, NY from 1963-1965, PostDoctoral Training

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Research Summary

Staphylococcus aureus, a major nosocomial pathogen, causes a wide variety of infections, from simple abscesses to fatal sepsis, plus toxinoses, such as food poisoning and toxic shock syndrome. S. aureus produces and secretes thirty or more specific pathogenicity factors, including superantigen toxins, hemolytic cytotoxins, tissue-component-degrading enzymes, and surface proteins, that interfere with host defenses. Its pathogenic versatility is compounded by its ability to develop resistance to new antibiotics almost as fast as they are introduced.

We have identified, sequenced, and characterized a global regulator, agr, that is the major regulatory element in a precisely orchestrated temporal program of virulence gene expression in vitro in Staphylococcus aureus. Agr consists of a 2-component signal transduction pathway, an autoinducing octapeptide (AIP) that serves as its ligand, and a regulatory RNA that controls target gene expression. The AIP contains a cyclic thioester bond between a conserved cysteine and the C-terminal carboxyl, which is presumably important for receptor binding. There are 4 or more groups of S. aureus strains that synthesize different AIPs; these activate agr expression within their group but inhibit agr expression in the other groups. We find that one of the AIPs can block infection by a heterologous strain in a mouse subcutaneous abscess model. We now study the biochemistry of AIP processing, the structure and function of the regulatory RNA, the expression of virulence factors in vivo, and the use of inhibitory peptides for antibacterial therapy.

Genes for staphylococcal superantigen toxins are often borne by plasmids and prophages. We find that the genes for TSST-1 and enterotoxin B are borne by a family of mobile pathogenicity islands, the first identified in staphylococci and the first for which mobility has been shown. These elements are 15 kb or more in size and are excised, caused to replicate, and encapsidated with high efficiency by certain staphylococcal phages. This results in an extremely high frequency of transduction. We are now analyzing the functions of these elements, the extent of their dissemination and the spectrum of pathogenicity genes that they carry.

Research Interests

Molecular Basis of Virulence in Staphylococcus aureus

Research Keywords

plasmids, replication signal transduction, Staphylococcus aureus, toxic shock syndrome, transposons, virulence

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Single-copy vectors for integration at the SaPI1 attachment site for Staphylococcus aureus
Chen, J; Yoong, P; Ram, G; Torres, V J; Novick, R P
2014 November 01, 2014;76(pp):1-7, Plasmid
— id: 1362902, year: 2014, vol: 76, page: 1, stat: Journal Article,

Solonamide B Inhibits Quorum Sensing and Reduces Staphylococcus aureus Mediated Killing of Human Neutrophils
Nielsen, Anita; Mansson, Maria; Bojer, Martin S; Gram, Lone; Larsen, Thomas O; Novick, Richard P; Frees, Dorte; Frokiaer, Hanne; Ingmer, Hanne
2014 ;9(1):e84992-e84992 e84992, PLoS one
— id: 741172, year: 2014, vol: 9, page: e84992, stat: Journal Article,

Staphylococcal pathogenicity island DNA packaging system involving cos-site packaging and phage-encoded HNH endonucleases
Quiles-Puchalt, Nuria; Carpena, Nuria; Alonso, Juan C; Novick, Richard P; Marina, Alberto; Penades, Jose R
2014 Apr;111(16):6016-6021, Proceedings of the National Academy of Sciences of the United States of America
— id: 980962, year: 2014, vol: 111, page: 6016, stat: Journal Article,

Precisely modulated pathogenicity island interference with late phage gene transcription
Ram, Geeta; Chen, John; Ross, Hope F; Novick, Richard P
2014 Oct;111(40):14536-14541, Proceedings of the National Academy of Sciences of the United States of America
— id: 1298892, year: 2014, vol: 111, page: 14536, stat: Journal Article,

Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions
Wang, Boyuan; Zhao, Aishan; Novick, Richard P; Muir, Tom W
2014 Mar;53(6):929-940, Molecular cell
— id: 952952, year: 2014, vol: 53, page: 929, stat: Journal Article,

THE LIMITS OF THE SELF Immunology and biological identity
Novick, Richard P.
2013 FEB 15;(5733):25-25, TLS, the Times literary supplement
— id: 370092, year: 2013, vol: , page: 25, stat: Journal Article,

A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria
Quiles-Puchalt, Nuria; Tormo-Mas, Maria Angeles; Campoy, Susana; Toledo-Arana, Alejandro; Monedero, Vicente; Lasa, Inigo; Novick, Richard P; Christie, Gail E; Penades, Jose R
2013 Aug;41(15):7260-7275, Nucleic acids research
— id: 549302, year: 2013, vol: 41, page: 7260, stat: Journal Article,

Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo
Alonzo Iii, Francis; Benson, Meredith A; Chen, John; Novick, Richard P; Shopsin, Bo; Torres, Victor J
2012 Jan;83(2):423-435, Molecular microbiology
— id: 149802, year: 2012, vol: 83, page: 423, stat: Journal Article,

The roles of SaPI1 proteins gp7 (CpmA) and gp6 (CpmB) in capsid size determination and helper phage interference
Damle, Priyadarshan K; Wall, Erin A; Spilman, Michael S; Dearborn, Altaira D; Ram, Geeta; Novick, Richard P; Dokland, Terje; Christie, Gail E
2012 Oct;432(2):277-282, Virology
— id: 177230, year: 2012, vol: 432, page: 277, stat: Journal Article,

Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor (Journal of Biological Chemistry (2012) 283, (8930-8938))
Geisinger, E; George, E A; Chen, J; Muir, T W; Novick, R P
2012 25 May 2012;287(22):18588-, Journal of biological chemistry
— id: 169573, year: 2012, vol: 287, page: 18588, stat: Journal Article,

Allele-Dependent Differences in Quorum-Sensing Dynamics Result in Variant Expression of Virulence Genes in Staphylococcus aureus
Geisinger, Edward; Chen, John; Novick, Richard P
2012 Jun;194(11):2854-2864, Journal of bacteriology
— id: 166819, year: 2012, vol: 194, page: 2854, stat: Journal Article,

Intravital two-photon microscopy of host-pathogen interactions in a mouse model of Staphylococcus aureus skin abscess formation
Liese, Jan; Rooijakkers, Suzan H M; van Strijp, Jos A G; Novick, Richard P; Dustin, Michael L
2012 Dec;:891-909, Cellular microbiology
— id: 210692, year: 2012, vol: , page: 891, stat: Journal Article,

Control of Staphylococcus aureus pathogenicity island excision
Mir-Sanchis, Ignacio; Martinez-Rubio, Roser; Marti, Miguel; Chen, John; Lasa, Inigo; Novick, Richard P; Tormo-Mas, Maria Angeles; Penades, Jose R
2012 Sep;85(5):833-845, Molecular microbiology
— id: 178120, year: 2012, vol: 85, page: 833, stat: Journal Article,

Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism
Ram, Geeta; Chen, John; Kumar, Krishan; Ross, Hope F; Ubeda, Carles; Damle, Priyadarshan K; Lane, Kristin D; Penades, Jose R; Christie, Gail E; Novick, Richard P
2012 Oct;109(40):16300-16305, Proceedings of the National Academy of Sciences of the United States of America
— id: 179089, year: 2012, vol: 109, page: 16300, stat: Journal Article,

Nasal Carriage as a Source of agr-Defective Staphylococcus aureus Bacteremia
Smyth, Davida S; Kafer, Jared M; Wasserman, Gregory A; Velickovic, Lili; Mathema, Barun; Holzman, Robert S; Knipe, Tiffany A; Becker, Karsten; von Eiff, Christof; Peters, Georg; Chen, Liang; Kreiswirth, Barry N; Novick, Richard P; Shopsin, Bo
2012 Oct;206(8):1168-1177, Journal of infectious diseases
— id: 178839, year: 2012, vol: 206, page: 1168, stat: Journal Article,

Structure-function analysis of the SaPIbov1 replication origin in Staphylococcus aureus
Ubeda, Carles; Tormo-Mas, Maria Angeles; Penades, Jose R; Novick, Richard P
2012 Mar;67(2):183-190, Plasmid
— id: 163567, year: 2012, vol: 67, page: 183, stat: Journal Article,

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner
Benson, Meredith A; Lilo, Sarit; Wasserman, Gregory A; Thoendel, Matthew; Smith, Amanda; Horswill, Alexander R; Fraser, John; Novick, Richard P; Shopsin, Bo; Torres, Victor J
2011 Aug;81(3):659-675, Molecular microbiology
— id: 137439, year: 2011, vol: 81, page: 659, stat: Journal Article,

RinA controls phage-mediated packaging and transfer of virulence genes in Gram-positive bacteria
Ferrer, Maria Desamparados; Quiles-Puchalt, Nuria; Harwich, Michael D; Tormo-Mas, Maria Angeles; Campoy, Susana; Barbe, Jordi; Lasa, Inigo; Novick, Richard P; Christie, Gail E; Penades, Jose R
2011 Aug;39(14):5866-5878, Nucleic acids research
— id: 138004, year: 2011, vol: 39, page: 5866, stat: Journal Article,

Exfoliatin-Producing Strains Define a Fourth agr Specificity Group in Staphylococcus aureus (vol 182, pg 6517, 2000)
Jarraud, S.; Lyon, G. J.; Figueiredo, A. M. S.; Lina, G.; Vandenesch, F.; Etienne, J.; Muir, T. W.; Novick, R. P.
2011 DEC ;193(24):7027-7027, Journal of bacteriology
— id: 147716, year: 2011, vol: 193, page: 7027, stat: Journal Article,

Intravital two-photon microscopy of Staphylococcus aureus skin infections
Liese J.; Novick R.P.; Dustin M.L.
2011 ;301:47-47, International journal of medical microbiology : IJMM
— id: 149831, year: 2011, vol: 301, page: 47, stat: Journal Article,

The complete genomes of Staphylococcus aureus bacteriophages 80 and 80alpha--implications for the specificity of SaPI mobilization
Christie, G E; Matthews, A M; King, D G; Lane, K D; Olivarez, N P; Tallent, S M; Gill, S R; Novick, R P
2010 Nov;407(2):381-390, Virology
— id: 210702, year: 2010, vol: 407, page: 381, stat: Journal Article,

Climate change and the integrity of science
Gleick, P H; Adams, R M; Amasino, R M; Anders, E; Anderson, D J; Anderson, W W; Anselin, L E; Arroyo, M K; Asfaw, B; Ayala, F J; Bax, A; Bebbington, A J; Bell, G; Bennett, M V L; Bennetzen, J L; Berenbaum, M R; Berlin, O B; Bjorkman, P J; Blackburn, E; Blamont, J E; Botchan, M R; Boyer, J S; Boyle, E A; Branton, D; Briggs, S P; Briggs, W R; Brill, W J; Britten, R J; Broecker, W S; Brown, J H; Brown, P O; Brunger, A T; Cairns, J Jr; Canfield, D E; Carpenter, S R; Carrington, J C; Cashmore, A R; Castilla, J C; Cazenave, A; Chapin, F S 3rd; Ciechanover, A J; Clapham, D E; Clark, W C; Clayton, R N; Coe, M D; Conwell, E M; Cowling, E B; Cowling, R M; Cox, C S; Croteau, R B; Crothers, D M; Crutzen, P J; Daily, G C; Dalrymple, G B; Dangl, J L; Darst, S A; Davies, D R; Davis, M B; De Camilli, P V; Dean, C; DeFries, R S; Deisenhofer, J; Delmer, D P; DeLong, E F; DeRosier, D J; Diener, T O; Dirzo, R; Dixon, J E; Donoghue, M J; Doolittle, R F; Dunne, T; Ehrlich, P R; Eisenstadt, S N; Eisner, T; Emanuel, K A; Englander, S W; Ernst, W G; Falkowski, P G; Feher, G; Ferejohn, J A; Fersht, A; Fischer, E H; Fischer, R; Flannery, K V; Frank, J; Frey, P A; Fridovich, I; Frieden, C; Futuyma, D J; Gardner, W R; Garrett, C J R; Gilbert, W; Goldberg, R B; Goodenough, W H; Goodman, C S; Goodman, M; Greengard, P; Hake, S; Hammel, G; Hanson, S; Harrison, S C; Hart, S R; Hartl, D L; Haselkorn, R; Hawkes, K; Hayes, J M; Hille, B; Hokfelt, T; House, J S; Hout, M; Hunten, D M; Izquierdo, I A; Jagendorf, A T; Janzen, D H; Jeanloz, R; Jencks, C S; Jury, W A; Kaback, H R; Kailath, T; Kay, P; Kay, S A; Kennedy, D; Kerr, A; Kessler, R C; Khush, G S; Kieffer, S W; Kirch, P V; Kirk, K; Kivelson, M G; Klinman, J P; Klug, A; Knopoff, L; Kornberg, H; Kutzbach, J E; Lagarias, J C; Lambeck, K; Landy, A; Langmuir, C H; Larkins, B A; Le Pichon, X T; Lenski, R E; Leopold, E B; Levin, S A; Levitt, M; Likens, G E; Lippincott-Schwartz, J; Lorand, L; Lovejoy, C O; Lynch, M; Mabogunje, A L; Malone, T F; Manabe, S; Marcus, J; Massey, D S; McWilliams, J C; Medina, E; Melosh, H J; Meltzer, D J; Michener, C D; Miles, E L; Mooney, H A; Moore, P B; Morel, F M M; Mosley-Thompson, E S; Moss, B; Munk, W H; Myers, N; Nair, G B; Nathans, J; Nester, E W; Nicoll, R A; Novick, R P; O'Connell, J F; Olsen, P E; Opdyke, N D; Oster, G F; Ostrom, E; Pace, N R; Paine, R T; Palmiter, R D; Pedlosky, J; Petsko, G A; Pettengill, G H; Philander, S G; Piperno, D R; Pollard, T D; Price, P B Jr; Reichard, P A; Reskin, B F; Ricklefs, R E; Rivest, R L; Roberts, J D; Romney, A K; Rossmann, M G; Russell, D W; Rutter, W J; Sabloff, J A; Sagdeev, R Z; Sahlins, M D; Salmond, A; Sanes, J R; Schekman, R; Schellnhuber, J; Schindler, D W; Schmitt, J; Schneider, S H; Schramm, V L; Sederoff, R R; Shatz, C J; Sherman, F; Sidman, R L; Sieh, K; Simons, E L; Singer, B H; Singer, M F; Skyrms, B; Sleep, N H; Smith, B D; Snyder, S H; Sokal, R R; Spencer, C S; Steitz, T A; Strier, K B; Sudhof, T C; Taylor, S S; Terborgh, J; Thomas, D H; Thompson, L G; Tjian, R T; Turner, M G; Uyeda, S; Valentine, J W; Valentine, J S; Van Etten, J L; van Holde, K E; Vaughan, M; Verba, S; von Hippel, P H; Wake, D B; Walker, A; Walker, J E; Watson, E B; Watson, P J; Weigel, D; Wessler, S R; West-Eberhard, M J; White, T D; Wilson, W J; Wolfenden, R V; Wood, J A; Woodwell, G M; Wright, H E Jr; Wu, C; Wunsch, C; Zoback, M L
2010 May;328(5979):689-690, Science
— id: 210722, year: 2010, vol: 328, page: 689, stat: Journal Article,

Repair of Global Regulators in Staphylococcus aureus 8325 and Comparative Analysis with Other Clinical Isolates
Herbert, S; Ziebandt, AK; Ohlsen, K; Schafer, T; Hecker, M; Albrecht, D; Novick, R; Gotz, F
2010 JUN ;78(6):2877-2889, Infection & immunity
— id: 109831, year: 2010, vol: 78, page: 2877, stat: Journal Article,

The phage-related chromosomal islands of Gram-positive bacteria
Novick, Richard P; Christie, Gail E; Penades, Jose R
2010 Aug;8(8):541-551, Nature reviews. Microbiology
— id: 111360, year: 2010, vol: 8, page: 541, stat: Journal Article,

Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus
Shopsin, Bo; Eaton, Christian; Wasserman, Gregory A; Mathema, Barun; Adhikari, Rajan P; Agolory, Simon; Altman, Deena R; Holzman, Robert S; Kreiswirth, Barry N; Novick, Richard P
2010 Nov 15;202(10):1593-1599, Journal of infectious diseases
— id: 113948, year: 2010, vol: 202, page: 1593, stat: Journal Article,

Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands
Tormo-Mas, Maria Angeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M; Campoy, Susana; Lasa, Inigo; Barbe, Jordi; Novick, Richard P; Christie, Gail E; Penades, Jose R
2010 Jun;465(7299):779-782, Nature
— id: 210712, year: 2010, vol: 465, page: 779, stat: Journal Article,

Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein
Viana, David; Blanco, Jose; Tormo-Mas, Maria Angeles; Selva, Laura; Guinane, Caitriona M; Baselga, Rafael; Corpa, Juan M; Lasa, Inigo; Novick, Richard P; Fitzgerald, J Ross; Penades, Jose R
2010 Sep;77(6):1583-1594, Molecular microbiology
— id: 133440, year: 2010, vol: 77, page: 1583, stat: Journal Article,

Phage-mediated intergeneric transfer of toxin genes
Chen, John; Novick, Richard P
2009 Jan 2;323(5910):139-141, Science
— id: 93388, year: 2009, vol: 323, page: 139, stat: Journal Article,

agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides
Geisinger, Edward; Muir, Tom W; Novick, Richard P
2009 Jan 27;106(4):1216-1221, Proceedings of the National Academy of Sciences of the United States of America
— id: 92775, year: 2009, vol: 106, page: 1216, stat: Journal Article,

Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC
George Cisar, Elizabeth A; Geisinger, Edward; Muir, Tom W; Novick, Richard P
2009 Oct;74(1):44-57, Molecular microbiology
— id: 106013, year: 2009, vol: 74, page: 44, stat: Journal Article,

Intravital two-photon microscopy as a method to analyze the cellular immune response during staphylococcus aureus induced abscess development
Liese J.; Novick R.P.; Dustin M.L.
2009 ;39:S626-S626, European journal of immunology
— id: 125474, year: 2009, vol: 39, page: S626, stat: Journal Article,

Killing niche competitors by remote-control bacteriophage induction
Selva, Laura; Viana, David; Regev-Yochay, Gili; Trzcinski, Krzysztof; Corpa, Juan Manuel; Lasa, Inigo; Novick, Richard P; Penades, Jose R
2009 Jan 27;106(4):1234-1238, Proceedings of the National Academy of Sciences of the United States of America
— id: 106012, year: 2009, vol: 106, page: 1234, stat: Journal Article,

Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations
Ubeda, Carles; Olivarez, Nicholas P; Barry, Peter; Wang, Huaibin; Kong, Xiangpeng; Matthews, Avery; Tallent, Sandra M; Christie, Gail E; Novick, Richard P
2009 Apr;72(1):98-108, Molecular microbiology
— id: 97845, year: 2009, vol: 72, page: 98, stat: Journal Article,

Regulatory organization of the staphylococcal sae locus
Adhikari, Rajan P; Novick, Richard P
2008 Mar;154(Pt 3):949-959, Microbiology (Reading, England)
— id: 78638, year: 2008, vol: 154, page: 949, stat: Journal Article,

Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor
Geisinger, Edward; George, Elizabeth A; Muir, Tom W; Novick, Richard P
2008 Apr 4;283(14):8930-8938, Journal of biological chemistry
— id: 78865, year: 2008, vol: 283, page: 8930, stat: Journal Article,

Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis
George, Elizabeth A; Novick, Richard P; Muir, Tom W
2008 Apr 9;130(14):4914-4924, Journal of the American Chemical Society
— id: 78863, year: 2008, vol: 130, page: 4914, stat: Journal Article,

REAL-TIME IN VIVO IMAGING OF LIVER STAGES OF PLASMODIUM YOEL
Mwakingwe, A; Ting, LM; Hochman, S; Chen, J; Novick, R; Sinnis, P; Kim, K
2008 DEC ;79(6):273-273, American journal of tropical medicine & hygiene
— id: 91862, year: 2008, vol: 79, page: 273, stat: Journal Article,

Mobile genetic elements of staphylococci
Novick RP
Horizontal gene transfer in the evolution of pathogenesis New York : Cambridge University Press, 2008,
— id: 5266, year: 2008, vol: , page: ?, stat: Chapter,

MRSA: RIP?
Novick, R
2008 FEB ;22(2):14-15, Scientist
— id: 75895, year: 2008, vol: 22, page: 14, stat: Journal Article,

Medicine. Combating impervious bugs
Novick, Richard P
2008 Feb 15;319(5865):910-911, Science
— id: 76118, year: 2008, vol: 319, page: 910, stat: Journal Article,

Quorum sensing in staphylococci
Novick, Richard P; Geisinger, Edward
2008 ;42:541-564, Annual review of genetics
— id: 92163, year: 2008, vol: 42, page: 541, stat: Journal Article,

Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains
Shopsin, Bo; Drlica-Wagner, Alex; Mathema, Barun; Adhikari, Rajan P; Kreiswirth, Barry N; Novick, Richard P
2008 Oct 15;198(8):1171-1174, Journal of infectious diseases
— id: 93361, year: 2008, vol: 198, page: 1171, stat: Journal Article,

Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins
Tormo, Maria Angeles; Ferrer, Maria Desamparados; Maiques, Elisa; Ubeda, Carles; Selva, Laura; Lasa, Inigo; Calvete, Juan J; Novick, Richard P; Penades, Jose R
2008 Apr;190(7):2434-2440, Journal of bacteriology
— id: 78864, year: 2008, vol: 190, page: 2434, stat: Journal Article,

agr function in clinical Staphylococcus aureus isolates
Traber, Katrina E; Lee, Elsie; Benson, Sarah; Corrigan, Rebecca; Cantera, Mariela; Shopsin, Bo; Novick, Richard P
2008 Aug;154(Pt 8):2265-2274, Microbiology (Reading, England)
— id: 87805, year: 2008, vol: 154, page: 2265, stat: Journal Article,

SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage
Ubeda, Carles; Maiques, Elisa; Barry, Peter; Matthews, Avery; Tormo, Maria Angeles; Lasa, Inigo; Novick, Richard P; Penades, Jose R
2008 Feb;67(3):493-503, Molecular microbiology
— id: 78866, year: 2008, vol: 67, page: 493, stat: Journal Article,

A nonsense mutation in agrA accounts for the defect in agr expression and the avirulence of Staphylococcus aureus 8325-4 traP::kan
Adhikari, Rajan P; Arvidson, Staffan; Novick, Richard P
2007 Sep;75(9):4534-4540, Infection & immunity
— id: 74300, year: 2007, vol: 75, page: 4534, stat: Journal Article,

svrA, a multi-drug exporter, does not control agr
Chen, John; Novick, Richard P
2007 May;153(Pt 5):1604-1608, Microbiology (Reading, England)
— id: 75358, year: 2007, vol: 153, page: 1604, stat: Journal Article,

Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer
Maiques, Elisa; Ubeda, Carles; Tormo, Maria Angeles; Ferrer, Maria Desamparados; Lasa, Inigo; Novick, Richard P; Penades, Jose R
2007 Aug;189(15):5608-5616, Journal of bacteriology
— id: 78868, year: 2007, vol: 189, page: 5608, stat: Journal Article,

The SaPIs: mobile pathogenicity islands of Staphylococcus
Novick, Richard P; Subedi, Abhignya
2007 ;93:42-57, Chemical immunology & allergy
— id: 72729, year: 2007, vol: 93, page: 42, stat: Journal Article,

Comparative genetics and replication of the mobile pathogenicity islands of the Staphylococci
Novick, RP; Ubeda, C
2007 MAR ;57(2):214-215, Plasmid
— id: 71467, year: 2007, vol: 57, page: 214, stat: Journal Article,

Bacterial Predictors of Outcome in Hospital-Acquired Pneumonia (HAP) Due to Methicillin-Resistant Staphylococcus aureus
Shopsin, B.; Creanga, D. L.; Riesman, A.; Hogan, P.; Thompson, C. A.; Kunkel, M. J.; Mathema, B.; Novick, R. P.; Kreiswirth, B. N.
2007 ;47(8):62-62, Program & abstracts (Interscience Conference on Antimicrobial Agents & Chemotherapy)
— id: 105018, year: 2007, vol: 47, page: 62, stat: Journal Article,

Sequence analysis reveals genetic exchanges and intraspecific spread of SaPI2, a pathogenicity island involved in menstrual toxic shock
Subedi, Abhignya; Ubeda, Carles; Adhikari, Rajan P; Penades, Jose R; Novick, Richard P
2007 Oct;153(Pt 10):3235-3245, Microbiology (Reading, England)
— id: 75384, year: 2007, vol: 153, page: 3235, stat: Journal Article,

A pathogenicity island replicon in Staphylococcus aureus replicates as an unstable plasmid
Ubeda, Carles; Barry, Peter; Penades, Jose R; Novick, Richard P
2007 Sep 4;104(36):14182-14188, Proceedings of the National Academy of Sciences of the United States of America
— id: 74458, year: 2007, vol: 104, page: 14182, stat: Journal Article,

SaPI operon I is required for SaPI packaging and is controlled by LexA
Ubeda, Carles; Maiques, Elisa; Tormo, Maria Angeles; Campoy, Susana; Lasa, Inigo; Barbe, Jordi; Novick, Richard P; Penades, Jose R
2007 Jul;65(1):41-50, Molecular microbiology
— id: 78867, year: 2007, vol: 65, page: 41, stat: Journal Article,

Inhibition of rot translation by RNAIII, a key feature of agr function
Geisinger, Edward; Adhikari, Rajan P; Jin, Ruzhong; Ross, Hope F; Novick, Richard P
2006 Aug;61(4):1038-1048, Molecular microbiology
— id: 68777, year: 2006, vol: 61, page: 1038, stat: Journal Article,

beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
Maiques, Elisa; Ubeda, Carles; Campoy, Susana; Salvador, Noelia; Lasa, Inigo; Novick, Richard P; Barbe, Jordi; Penades, Jose R
2006 Apr;188(7):2726-2729, Journal of bacteriology
— id: 63872, year: 2006, vol: 188, page: 2726, stat: Journal Article,

A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and alpha-haemolysins
Traber, Katrina; Novick, Richard
2006 Mar;59(5):1519-1530, Molecular microbiology
— id: 64136, year: 2006, vol: 59, page: 1519, stat: Journal Article,

Use of targetrons to disrupt essential and nonessential genes in Staphylococcus aureus reveals temperature sensitivity of Ll.LtrB group II intron splicing
Yao, Jun; Zhong, Jin; Fang, Yuan; Geisinger, Edward; Novick, Richard P; Lambowitz, Alan M
2006 Jul;12(7):1271-1281, RNA
— id: 64336, year: 2006, vol: 12, page: 1271, stat: Journal Article,

Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretion
Adhikari, Rajan P; Novick, Richard P
2005 Sep;151(Pt 9):3059-3069, Microbiology (Reading, England)
— id: 63874, year: 2005, vol: 151, page: 3059, stat: Journal Article,

Synthesis of dimeric quorum sensing peptides to probe virulence in S. aureus
George, EA; Wright, JS; Novick, RP; Muir, TW
2005 AUG ;80(4):541-541, Biopolymers
— id: 57691, year: 2005, vol: 80, page: 541, stat: Journal Article,

Staphylococcus intermedius produces a functional agr autoinducing peptide containing a cyclic lactone
Ji, Guangyong; Pei, Wuhong; Zhang, Linsheng; Qiu, Rongde; Lin, Jianqun; Benito, Yvonne; Lina, Gerard; Novick, Richard P
2005 May;187(9):3139-3150, Journal of bacteriology
— id: 63876, year: 2005, vol: 187, page: 3139, stat: Journal Article,

Interrupters on the bacterial party line
Novick, Richard P
2005 Nov;1(6):321-322, Nature chemical biology
— id: 63873, year: 2005, vol: 1, page: 321, stat: Journal Article,

Quorum sensing and interference by bacterial autoinducing peptides
Novick, RP; Wright, JS
2005 AUG ;80(4):490-490, Biopolymers
— id: 57690, year: 2005, vol: 80, page: 490, stat: Journal Article,

Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
Sakoulas, George; Eliopoulos, George M; Fowler, Vance G Jr; Moellering, Robert C Jr; Novick, Richard P; Lucindo, Natalie; Yeaman, Michael R; Bayer, Arnold S
2005 Jul;49(7):2687-2692, Antimicrobial agents & chemotherapy
— id: 63875, year: 2005, vol: 49, page: 2687, stat: Journal Article,

Antibiotic-induced SOS response promotes horizontal dissemination of pathogenicity island-encoded virulence factors in staphylococci
Ubeda, Carles; Maiques, Elisa; Knecht, Erwin; Lasa, Inigo; Novick, Richard P; Penades, Jose R
2005 May;56(3):836-844, Molecular microbiology
— id: 63877, year: 2005, vol: 56, page: 836, stat: Journal Article,

Transient interference with staphylococcal quorum sensing blocks abscess formation [Journal Article D]
Wright, Jesse S 3rd; Jin, Rhuzong; Novick, Richard P
2005 Feb 1;102(5):1691-1696, Proceedings of the National Academy of Sciences of the United States of America
— id: 50289, year: 2005, vol: 102, page: 1691, stat: Journal Article,

The agr radiation: an early event in the evolution of staphylococci
Wright, Jesse S 3rd; Traber, Katrina E; Corrigan, Rebecca; Benson, Sarah A; Musser, James M; Novick, Richard P
2005 Aug;187(16):5585-5594, Journal of bacteriology
— id: 57844, year: 2005, vol: 187, page: 5585, stat: Journal Article,

Novel cassette-based shuttle vector system for gram-positive bacteria
Charpentier, Emmanuelle; Anton, Ana I; Barry, Peter; Alfonso, Berenice; Fang, Yuan; Novick, Richard P
2004 Oct;70(10):6076-6085, Applied & environmental microbiology
— id: 47807, year: 2004, vol: 70, page: 6076, stat: Journal Article,

Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria
Lyon, Gholson J; Novick, Richard P
2004 Sep;25(9):1389-1403, Peptides
— id: 63879, year: 2004, vol: 25, page: 1389, stat: Journal Article,

Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule
Mangold, Monika; Siller, Maria; Roppenser, Bernhard; Vlaminckx, Bart J M; Penfound, Tom A; Klein, Reinhard; Novak, Rodger; Novick, Richard P; Charpentier, Emmanuelle
2004 Sep;53(5):1515-1527, Molecular microbiology
— id: 63878, year: 2004, vol: 53, page: 1515, stat: Journal Article,

Systemic tumor targeting and killing by Sindbis viral vectors
Tseng, Jen-Chieh; Levin, Brandi; Hurtado, Alicia; Yee, Herman; Perez de Castro, Ignacio; Jimenez, Maria; Shamamian, Peter; Jin, Ruzhong; Novick, Richard P; Pellicer, Angel; Meruelo, Daniel
2004 Jan;22(1):70-77, Nature biotechnology
— id: 44812, year: 2004, vol: 22, page: 70, stat: Journal Article,

Effect of mild acid on gene expression in Staphylococcus aureus
Weinrick, Brian; Dunman, Paul M; McAleese, Fionnuala; Murphy, Ellen; Projan, Steven J; Fang, Yuan; Novick, Richard P
2004 Dec;186(24):8407-8423, Journal of bacteriology
— id: 48042, year: 2004, vol: 186, page: 8407, stat: Journal Article,

Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh
Wirth, Thierry; Wang, Xiaoyan; Linz, Bodo; Novick, Richard P; Lum, J Koji; Blaser, Martin; Morelli, Giovanna; Falush, Daniel; Achtman, Mark
2004 Apr 6;101(14):4746-4751, Proceedings of the National Academy of Sciences of the United States of America
— id: 63880, year: 2004, vol: 101, page: 4746, stat: Journal Article,

Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing
Wright, Jesse S 3rd; Lyon, Gholson J; George, Elizabeth A; Muir, Tom W; Novick, Richard P
2004 Nov 16;101(46):16168-16173, Proceedings of the National Academy of Sciences of the United States of America
— id: 47785, year: 2004, vol: 101, page: 16168, stat: Journal Article,

Autoinduction and signal transduction in the regulation of staphylococcal virulence
Novick, Richard P
2003 Jun;48(6):1429-1449, Molecular microbiology
— id: 39206, year: 2003, vol: 48, page: 1429, stat: Journal Article,

Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus
Novick, Richard P
2003 Mar;49(2):93-105, Plasmid
— id: 39235, year: 2003, vol: 49, page: 93, stat: Journal Article,

The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing
Novick, Richard P; Jiang, Dunrong
2003 Oct;149(Pt 10):2709-2717, Microbiology (Reading, England)
— id: 39045, year: 2003, vol: 149, page: 2709, stat: Journal Article,

Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?
Sakoulas, George; Eliopoulos, George M; Moellering, Robert C Jr; Novick, Richard P; Venkataraman, Lata; Wennersten, Christine; DeGirolami, Paola C; Schwaber, Mitchell J; Gold, Howard S
2003 Mar 15;187(6):929-938, Journal of infectious diseases
— id: 63881, year: 2003, vol: 187, page: 929, stat: Journal Article,

High genetic variability of the agr locus in Staphylococcus species
Dufour, Philippe; Jarraud, Sophie; Vandenesch, Francois; Greenland, Timothy; Novick, Richard P; Bes, Michele; Etienne, Jerome; Lina, Gerard
2002 Feb;184(4):1180-1186, Journal of bacteriology
— id: 63885, year: 2002, vol: 184, page: 1180, stat: Journal Article,

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling
Lyon, Gholson J; Wright, Jesse S; Christopoulos, Arthur; Novick, Richard P; Muir, Tom W
2002 Feb 22;277(8):6247-6253, Journal of biological chemistry
— id: 63886, year: 2002, vol: 277, page: 6247, stat: Journal Article,

Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus
Lyon, Gholson J; Wright, Jesse S; Muir, Tom W; Novick, Richard P
2002 Aug 6;41(31):10095-10104, Biochemistry
— id: 63882, year: 2002, vol: 41, page: 10095, stat: Journal Article,

Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and Cag A antigens
Romero-Gallo, Judith; Perez-Perez, Guillermo I; Novick, Richard P; Kamath, Patrick; Norbu, Tsering; Blaser, Martin J
2002 Nov;9(6):1313-1317, Clinical & diagnostic laboratory immunology
— id: 34578, year: 2002, vol: 9, page: 1313, stat: Journal Article,

Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
Sakoulas, George; Eliopoulos, George M; Moellering, Robert C Jr; Wennersten, Christine; Venkataraman, Lata; Novick, Richard P; Gold, Howard S
2002 May;46(5):1492-1502, Antimicrobial agents & chemotherapy
— id: 63884, year: 2002, vol: 46, page: 1492, stat: Journal Article,

Global repression of exotoxin synthesis by staphylococcal superantigens
Vojtov, Nikola; Ross, Hope F; Novick, Richard P
2002 Jul 23;99(15):10102-10107, Proceedings of the National Academy of Sciences of the United States of America
— id: 39618, year: 2002, vol: 99, page: 10102, stat: Journal Article,

Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus
Zhang, Linsheng; Gray, Lillian; Novick, Richard P; Ji, Guangyong
2002 Sep 20;277(38):34736-34742, Journal of biological chemistry
— id: 63883, year: 2002, vol: 277, page: 34736, stat: Journal Article,

Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in Staphylococcus aureus
Herbert S; Barry P; Novick RP
2001 May;69(5):2996-3003, Infection & immunity
— id: 21210, year: 2001, vol: 69, page: 2996, stat: Journal Article,

Role of the double-strand origin cruciform in pT181 replication
Jin R; Novick RP
2001 Sep;46(2):95-105, Plasmid
— id: 26606, year: 2001, vol: 46, page: 95, stat: Journal Article,

Pathogenicity and resistance islands of staphylococci
Novick RP; Schlievert P; Ruzin A
2001 Jun;3(7):585-594, Microbes & infection
— id: 21173, year: 2001, vol: 3, page: 585, stat: Journal Article,

Biochemical and biological properties of Staphylococcal enterotoxin K
Orwin PM; Leung DY; Donahue HL; Novick RP; Schlievert PM
2001 Jan;69(1):360-366, Infection & immunity
— id: 63888, year: 2001, vol: 69, page: 360, stat: Journal Article,

Molecular genetics of SaPI1--a mobile pathogenicity island in Staphylococcus aureus
Ruzin A; Lindsay J; Novick RP
2001 Jul;41(2):365-377, Molecular microbiology
— id: 63887, year: 2001, vol: 41, page: 365, stat: Journal Article,

Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus
Jarraud S; Lyon GJ; Figueiredo AM; Gerard L; Vandenesch F; Etienne J; Muir TW; Novick RP
2000 Nov;182(22):6517-6522, Journal of bacteriology
— id: 63890, year: 2000, vol: 182, page: 6517, stat: Journal Article,

Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC
Lyon GJ; Mayville P; Muir TW; Novick RP
2000 Nov 21;97(24):13330-13335, Proceedings of the National Academy of Sciences of the United States of America
— id: 63889, year: 2000, vol: 97, page: 13330, stat: Journal Article,

Sortase: the surface protein anchoring transpeptidase and the LPXTG motif
Novick RP
2000 Apr;8(4):148-151, Trends in microbiology
— id: 11765, year: 2000, vol: 8, page: 148, stat: Journal Article,

Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus
Ruzin A; Novick RP
2000 May;182(9):2668-2671, Journal of bacteriology
— id: 11757, year: 2000, vol: 182, page: 2668, stat: Journal Article,

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence
Mayville P; Ji G; Beavis R; Yang H; Goger M; Novick RP; Muir TW
1999 Feb 16;96(4):1218-1223, Proceedings of the National Academy of Sciences of the United States of America
— id: 57051, year: 1999, vol: 96, page: 1218, stat: Journal Article,

Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria
Novick RP; Muir TW
1999 Feb;2(1):40-45, Current opinion in microbiology
— id: 7418, year: 1999, vol: 2, page: 40, stat: Journal Article,

Activity of nisin against Streptococcus pneumoniae, in vitro, a mouse infection model - J Antimicrob Chemother 1998; 42 : 277-278
Goldstein, BP; Wei, J; Greenberg, K; Novick, R
1998 AUG ;42(2):277-278, Journal of antimicrobial chemotherapy
— id: 53385, year: 1998, vol: 42, page: 277, stat: Journal Article,

Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus
Lina G; Jarraud S; Ji G; Greenland T; Pedraza A; Etienne J; Novick RP; Vandenesch F
1998 May;28(3):655-662, Molecular microbiology
— id: 7660, year: 1998, vol: 28, page: 655, stat: Journal Article,

The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus
Lindsay JA; Ruzin A; Ross HF; Kurepina N; Novick RP
1998 Jul;29(2):527-543, Molecular microbiology
— id: 7661, year: 1998, vol: 29, page: 527, stat: Journal Article,

Contrasting lifestyles of rolling-circle phages and plasmids
Novick RP
1998 Nov;23(11):434-438, Trends in biochemical sciences
— id: 7417, year: 1998, vol: 23, page: 434, stat: Journal Article,

Glycerol monolaurate inhibits induction of vancomycin resistance in Enterococcus faecalis
Ruzin A; Novick RP
1998 Jan;180(1):182-185, Journal of bacteriology
— id: 7774, year: 1998, vol: 180, page: 182, stat: Journal Article,

Bacterial interference caused by autoinducing peptide variants
Ji G; Beavis R; Novick RP
1997 Jun 27;276(5321):2027-2030, Science
— id: 7174, year: 1997, vol: 276, page: 2027, stat: Journal Article,

Why is the initiation nick site of an AT-rich rolling circle plasmid at the tip of a GC-rich cruciform?
Jin R; Fernandez-Beros ME; Novick RP
1997 Jul 16;16(14):4456-4466, EMBO journal
— id: 7175, year: 1997, vol: 16, page: 4456, stat: Journal Article,

In vitro inhibitory activity of RepC/C*, the inactivated form of the pT181 plasmid initiation protein, RepC
Jin R; Rasooly A; Novick RP
1997 Jan;179(1):141-147, Journal of bacteriology
— id: 12440, year: 1997, vol: 179, page: 141, stat: Journal Article,

The inactive pT181 initiator heterodimer, RepC/C, binds but fails to induce melting of the plasmid replication origin
Jin R; Zhou X; Novick RP
1996 Dec 6;271(49):31086-31091, Journal of biological chemistry
— id: 12449, year: 1996, vol: 271, page: 31086, stat: Journal Article,

Localization of biologically important regions on toxic shock syndrome toxin 1
Murray DL; Earhart CA; Mitchell DT; Ohlendorf DH; Novick RP; Schlievert PM
1996 Jan;64(1):371-374, Infection & immunity
— id: 63892, year: 1996, vol: 64, page: 371, stat: Journal Article,

Mycobacteria : growth, metabolism, and molecular biology
Novick, Richard
Tuberculosis Boston : Little Brown, 1996,
— id: 4829, year: 1996, vol: , page: ?, stat: Chapter,

Modulation of immune cell proliferation by glycerol monolaurate
Witcher KJ; Novick RP; Schlievert PM
1996 Jan;3(1):10-13, Clinical & diagnostic laboratory immunology
— id: 63891, year: 1996, vol: 3, page: 10, stat: Journal Article,

Autocrine regulation of toxin synthesis by Staphylococcus aureus
Balaban N; Novick RP
1995 Feb 28;92(5):1619-1623, Proceedings of the National Academy of Sciences of the United States of America
— id: 56612, year: 1995, vol: 92, page: 1619, stat: Journal Article,

Translation of RNAIII, the Staphylococcus aureus agr regulatory RNA molecule, can be activated by a 3'-end deletion
Balaban N; Novick RP
1995 Nov 1;133(1-2):155-161, FEMS microbiology letters
— id: 63893, year: 1995, vol: 133, page: 155, stat: Journal Article,

Cell density control of staphylococcal virulence mediated by an octapeptide pheromone
Ji G; Beavis RC; Novick RP
1995 Dec 19;92(26):12055-12059, Proceedings of the National Academy of Sciences of the United States of America
— id: 56827, year: 1995, vol: 92, page: 12055, stat: Journal Article,

Molecular epidemiology of Staphylococcus epidermidis blood isolates from neonatal intensive care unit patients
Nesin M; Projan SJ; Kreiswirth B; Bolt Y; Novick RP
1995 Oct;31(2):111-121, Journal of hospital infection
— id: 63894, year: 1995, vol: 31, page: 111, stat: Journal Article,

The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus
Novick RP; Projan SJ; Kornblum J; Ross HF; Ji G; Kreiswirth B; Vandenesch F; Moghazeh S
1995 Aug 30;248(4):446-458, Molecular & general genetics
— id: 63895, year: 1995, vol: 248, page: 446, stat: Journal Article,

Coagulase expression in Staphylococcus aureus is positively and negatively modulated by an agr-dependent mechanism
Lebeau C; Vandenesch F; Greenland T; Novick RP; Etienne J
1994 Sep;176(17):5534-5536, Journal of bacteriology
— id: 64337, year: 1994, vol: 176, page: 5534, stat: Journal Article,

Immunobiologic and biochemical properties of mutants of toxic shock syndrome toxin-1
Murray DL; Prasad GS; Earhart CA; Leonard BA; Kreiswirth BN; Novick RP; Ohlendorf DH; Schlievert PM
1994 Jan 1;152(1):87-95, Journal of immunology (1950)
— id: 63898, year: 1994, vol: 152, page: 87, stat: Journal Article,

Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction
Projan SJ; Brown-Skrobot S; Schlievert PM; Vandenesch F; Novick RP
1994 Jul;176(14):4204-4209, Journal of bacteriology
— id: 63896, year: 1994, vol: 176, page: 4204, stat: Journal Article,

Plasmids of the pT181 family show replication-specific initiator protein modification
Rasooly A; Projan SJ; Novick RP
1994 Apr;176(8):2450-2453, Journal of bacteriology
— id: 6492, year: 1994, vol: 176, page: 2450, stat: Journal Article,

Replication-specific conversion of the Staphylococcus aureus pT181 initiator protein from an active homodimer to an inactive heterodimer
Rasooly A; Wang PZ; Novick RP
1994 Nov 1;13(21):5245-5251, EMBO journal
— id: 12873, year: 1994, vol: 13, page: 5245, stat: Journal Article,

Coagulase deficiency in clinical isolates of Staphylococcus aureus involves both transcriptional and post-transcriptional defects
Vandenesch F; Lebeau C; Bes M; McDevitt D; Greenland T; Novick RP; Etienne J
1994 May;40(5):344-349, Journal of medical microbiology
— id: 63897, year: 1994, vol: 40, page: 344, stat: Journal Article,

Measurement of gene expression by translational coupling: effect of copy mutations on pT181 initiator synthesis
Bargonetti J; Wang PZ; Novick RP
1993 Sep;12(9):3659-3667, EMBO journal
— id: 63902, year: 1993, vol: 12, page: 3659, stat: Journal Article,

Growth and analysis of crystal forms of toxic shock syndrome toxin 1
Earhart CA; Prasad GS; Murray DL; Novick RP; Schlievert PM; Ohlendorf DH
1993 Nov;17(3):329-334, Proteins
— id: 63901, year: 1993, vol: 17, page: 329, stat: Journal Article,

Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus
Kreiswirth B; Kornblum J; Arbeit RD; Eisner W; Maslow JN; McGeer A; Low DE; Novick RP
1993 Jan 8;259(5092):227-230, Science
— id: 63904, year: 1993, vol: 259, page: 227, stat: Journal Article,

Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule
Novick RP; Ross HF; Projan SJ; Kornblum J; Kreiswirth B; Moghazeh S
1993 Oct;12(10):3967-3975, EMBO journal
— id: 8345, year: 1993, vol: 12, page: 3967, stat: Journal Article,

Structure of toxic shock syndrome toxin 1
Prasad GS; Earhart CA; Murray DL; Novick RP; Schlievert PM; Ohlendorf DH
1993 Dec 21;32(50):13761-13766, Biochemistry
— id: 63899, year: 1993, vol: 32, page: 13761, stat: Journal Article,

Glycerol monolaurate inhibits production of Staphylococcus aureus beta-lactamase by blocking induction
Projan S; Mandal S; Moghazeh S; Novick R
1993 ;?:16-16, Abstracts of the ... general meeting of the American Society for Microbiology
— id: 84012, year: 1993, vol: ?, page: 16, stat: Journal Article,

Replication-specific inactivation of the pT181 plasmid initiator protein
Rasooly A; Novick RP
1993 Nov 12;262(5136):1048-1050, Science
— id: 63900, year: 1993, vol: 262, page: 1048, stat: Journal Article,

Agr-related sequences in Staphylococcus lugdunensis
Vandenesch F; Projan SJ; Kreiswirth B; Etienne J; Novick RP
1993 Jul 15;111(1):115-122, FEMS microbiology letters
— id: 63903, year: 1993, vol: 111, page: 115, stat: Journal Article,

Origin recognition specificity in pT181 plasmids is determined by a functionally asymmetric palindromic DNA element
Wang PZ; Projan SJ; Henriquez V; Novick RP
1993 Jan;12(1):45-52, EMBO journal
— id: 63905, year: 1993, vol: 12, page: 45, stat: Journal Article,

Nucleotide sequences and biologic properties of toxic shock syndrome toxin 1 from ovine- and bovine-associated Staphylococcus aureus
Lee PK; Kreiswirth BN; Deringer JR; Projan SJ; Eisner W; Smith BL; Carlson E; Novick RP; Schlievert PM
1992 Jun;165(6):1056-1063, Journal of infectious diseases
— id: 63907, year: 1992, vol: 165, page: 1056, stat: Journal Article,

cis-inhibitory elements in the pT181 replication system
Projan SJ; Novick RP
1992 Mar;27(2):81-92, Plasmid
— id: 63909, year: 1992, vol: 27, page: 81, stat: Journal Article,

Glucose and nonmaintained pH decrease expression of the accessory gene regulator (agr) in Staphylococcus aureus
Regassa LB; Novick RP; Betley MJ
1992 Aug;60(8):3381-3388, Infection & immunity
— id: 63906, year: 1992, vol: 60, page: 3381, stat: Journal Article,

Effect of glycerol monolaurate on bacterial growth and toxin production
Schlievert PM; Deringer JR; Kim MH; Projan SJ; Novick RP
1992 Mar;36(3):626-631, Antimicrobial agents & chemotherapy
— id: 63908, year: 1992, vol: 36, page: 626, stat: Journal Article,

Specificity of origin recognition by replication initiator protein in plasmids of the pT181 family is determined by a six amino acid residue element
Wang PZ; Projan SJ; Henriquez V; Novick RP
1992 Jan 5;223(1):145-158, Journal of molecular biology
— id: 63910, year: 1992, vol: 223, page: 145, stat: Journal Article,

Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins
Lee PK; Deringer JR; Kreiswirth BN; Novick RP; Schlievert PM
1991 Mar;59(3):879-884, Infection & immunity
— id: 63914, year: 1991, vol: 59, page: 879, stat: Journal Article,

Genetic systems in staphylococci
Novick RP
1991 ;204:587-636, Methods in enzymology
— id: 63916, year: 1991, vol: 204, page: 587, stat: Journal Article,

In memoriam. Royston C. Clowes (1921-1989)
Novick RP
1991 Jan;25(1):1-2, Plasmid
— id: 63915, year: 1991, vol: 25, page: 1, stat: Journal Article,

A temporal signal, independent of agr, is required for hla but not spa transcription in Staphylococcus aureus
Vandenesch F; Kornblum J; Novick RP
1991 Oct;173(20):6313-6320, Journal of bacteriology
— id: 63911, year: 1991, vol: 173, page: 6313, stat: Journal Article,

The effect of plasmid copy number mutations on pT181 replication initiator protein expression
Wang PZ; Henriquez VB; Projan SJ; Iordanescu S; Novick RP
1991 May;25(3):198-207, Plasmid
— id: 63913, year: 1991, vol: 25, page: 198, stat: Journal Article,

Nucleotide sequence of beta-lactamase regulatory genes from staphylococcal plasmid pI258
Wang PZ; Projan SJ; Novick RP
1991 Jul 25;19(14):4000-4000, Nucleic acids research
— id: 63912, year: 1991, vol: 19, page: 4000, stat: Journal Article,

Mutational and physiological analyses of plasmid pT181 functions expressing incompatibility
Highlander SK; Novick RP
1990 Jan;23(1):1-15, Plasmid
— id: 63920, year: 1990, vol: 23, page: 1, stat: Journal Article,

Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: association with enterotoxin A
McCollister BD; Kreiswirth BN; Novick RP; Schlievert PM
1990 Jul;58(7):2067-2070, Infection & immunity
— id: 63918, year: 1990, vol: 58, page: 2067, stat: Journal Article,

Initiation of rolling-circle replication in pT181 plasmid: initiator protein enhances cruciform extrusion at the origin
Noirot P; Bargonetti J; Novick RP
1990 Nov;87(21):8560-8564, Proceedings of the National Academy of Sciences of the United States of America
— id: 63917, year: 1990, vol: 87, page: 8560, stat: Journal Article,

Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1
Norton SD; Schlievert PM; Novick RP; Jenkins MK
1990 Mar 15;144(6):2089-2095, Journal of immunology (1950)
— id: 63919, year: 1990, vol: 144, page: 2089, stat: Journal Article,

Molecular biology of the staphlococci
Novick, Richard P
New York : VCH Publishers, 1990,
— id: 992, year: 1990, vol: , page: , stat: ,

Analysis of toxic shock syndrome isolates producing staphylococcal enterotoxins B and C1 with use of southern hybridization and immunologic assays
Bohach GA; Kreiswirth BN; Novick RP; Schlievert PM
1989 Jan-Feb;11 Suppl 1:S75-81; discussion S81, Reviews of infectious diseases
— id: 63926, year: 1989, vol: 11 Suppl 1, page: S75, stat: Journal Article,

Functional organization of the plasmid pT181 replication origin
Gennaro ML; Iordanescu S; Novick RP; Murray RW; Steck TR; Khan SA
1989 Jan 20;205(2):355-362, Journal of molecular biology
— id: 63923, year: 1989, vol: 205, page: 355, stat: Journal Article,

Toxic shock syndrome toxin 1 is encoded by a variable genetic element
Kreiswirth BN; Projan SJ; Schlievert PM; Novick RP
1989 Jan-Feb;11 Suppl 1:S83-8; discussion S88, Reviews of infectious diseases
— id: 63925, year: 1989, vol: 11 Suppl 1, page: S83, stat: Journal Article,

Staphylococcal plasmids and their replication
Novick RP
1989 ;43:537-565, Annual review of microbiology
— id: 63924, year: 1989, vol: 43, page: 537, stat: Journal Article,

pT181 plasmid replication is regulated by a countertranscript-driven transcriptional attenuator
Novick RP; Iordanescu S; Projan SJ; Kornblum J; Edelman I
1989 Oct 20;59(2):395-404, Cell
— id: 63921, year: 1989, vol: 59, page: 395, stat: Journal Article,

Nucleotide sequence: the beta-hemolysin gene of Staphylococcus aureus
Projan SJ; Kornblum J; Kreiswirth B; Moghazeh SL; Eisner W; Novick RP
1989 Apr 25;17(8):3305-3305, Nucleic acids research
— id: 63922, year: 1989, vol: 17, page: 3305, stat: Journal Article,

Association of toxic shock toxin-1 determinant with a heterologous insertion at multiple loci in the Staphylococcus aureus chromosome
Chu MC; Kreiswirth BN; Pattee PA; Novick RP; Melish ME; James JF
1988 Oct;56(10):2702-2708, Infection & immunity
— id: 63928, year: 1988, vol: 56, page: 2702, stat: Journal Article,

An enhancer of DNA replication
Gennaro ML; Novick RP
1988 Dec;170(12):5709-5717, Journal of bacteriology
— id: 63927, year: 1988, vol: 170, page: 5709, stat: Journal Article,

A rapid method to quantitate non-labeled RNA species in bacterial cells
Kornblum JS; Projan SJ; Moghazeh SL; Novick RP
1988 ;63(1):75-85, Gene
— id: 63933, year: 1988, vol: 63, page: 75, stat: Journal Article,

Intermediates in plasmid pT181 DNA replication
Majumder S; Novick RP
1988 Apr 11;16(7):2897-2912, Nucleic acids research
— id: 63931, year: 1988, vol: 16, page: 2897, stat: Journal Article,

Localization of a biologically important epitope on toxic-shock-syndrome toxin-1
Murphy BG; Kreiswirth BN; Novick RP; Schlievert PM
1988 Sep;158(3):549-555, Journal of infectious diseases
— id: 63929, year: 1988, vol: 158, page: 549, stat: Journal Article,

Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus
Peng HL; Novick RP; Kreiswirth B; Kornblum J; Schlievert P
1988 Sep;170(9):4365-4372, Journal of bacteriology
— id: 63930, year: 1988, vol: 170, page: 4365, stat: Journal Article,

Nucleotide sequence of pS194, a streptomycin-resistance plasmid from Staphylococcus aureus
Projan SJ; Moghazeh S; Novick RP
1988 Mar 25;16(5):2179-2187, Nucleic acids research
— id: 63932, year: 1988, vol: 16, page: 2179, stat: Journal Article,

A site-specific recombination function in Staphylococcus aureus plasmids
Gennaro ML; Kornblum J; Novick RP
1987 Jun;169(6):2601-2610, Journal of bacteriology
— id: 63937, year: 1987, vol: 169, page: 2601, stat: Journal Article,

Functional analysis of a palindromic sequence required for normal replication of several staphylococcal plasmids
Gruss AD; Ross HF; Novick RP
1987 Apr;84(8):2165-2169, Proceedings of the National Academy of Sciences of the United States of America
— id: 63940, year: 1987, vol: 84, page: 2165, stat: Journal Article,

Plasmid repopulation kinetics in Staphylococcus aureus
Highlander SK; Novick RP
1987 May;17(3):210-221, Plasmid
— id: 63939, year: 1987, vol: 17, page: 210, stat: Journal Article,

Cloning and expression of streptococcal pyrogenic exotoxin A and staphylococcal toxic shock syndrome toxin-1 in Bacillus subtilis
Kreiswirth BN; Handley JP; Schlievert PM; Novick RP
1987 Jun;208(1-2):84-87, Molecular & general genetics
— id: 63938, year: 1987, vol: 208, page: 84, stat: Journal Article,

Evaluation of coagulase-negative staphylococci for ability to produce toxic shock syndrome toxin 1
Kreiswirth BN; Schlievert PM; Novick RP
1987 Oct;25(10):2028-2029, Journal of clinical microbiology
— id: 63935, year: 1987, vol: 25, page: 2028, stat: Journal Article,

Plasmid incompatibility
Novick RP
1987 Dec;51(4):381-395, Microbiological reviews
— id: 63934, year: 1987, vol: 51, page: 381, stat: Journal Article,

Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans
Recsei PA; Gruss AD; Novick RP
1987 Mar;84(5):1127-1131, Proceedings of the National Academy of Sciences of the United States of America
— id: 63942, year: 1987, vol: 84, page: 1127, stat: Journal Article,

Nucleotide sequence and expression of the beta-lactamase gene from Staphylococcus aureus plasmid pI258 in Escherichia coli, Bacillus subtilis, and Staphylococcus aureus
Wang PZ; Novick RP
1987 Apr;169(4):1763-1766, Journal of bacteriology
— id: 63941, year: 1987, vol: 169, page: 1763, stat: Journal Article,

Translational fusion with a secretory enzyme as an indicator
Wang PZ; Projan SJ; Leason KR; Novick RP
1987 Jul;169(7):3082-3087, Journal of bacteriology
— id: 63936, year: 1987, vol: 169, page: 3082, stat: Journal Article,

The nucleotide and partial amino acid sequence of toxic shock syndrome toxin-1
Blomster-Hautamaa DA; Kreiswirth BN; Kornblum JS; Novick RP; Schlievert PM
1986 Nov 25;261(33):15783-15786, Journal of biological chemistry
— id: 63945, year: 1986, vol: 261, page: 15783, stat: Journal Article,

Resolution of highly purified toxic-shock syndrome toxin 1 into two distinct proteins by isoelectric focusing
Blomster-Hautamaa DA; Kreiswirth BN; Novick RP; Schlievert PM
1986 Jan 14;25(1):54-59, Biochemistry
— id: 63951, year: 1986, vol: 25, page: 54, stat: Journal Article,

Localization of biologic functions of toxic shock syndrome toxin-1 by use of monoclonal antibodies and cyanogen bromide-generated toxin fragments
Blomster-Hautamaa DA; Novick RP; Schlievert PM
1986 Dec 1;137(11):3572-3576, Journal of immunology (1950)
— id: 63943, year: 1986, vol: 137, page: 3572, stat: Journal Article,

cmp, a cis-acting plasmid locus that increases interaction between replication origin and initiator protein
Gennaro ML; Novick RP
1986 Oct;168(1):160-166, Journal of bacteriology
— id: 63948, year: 1986, vol: 168, page: 160, stat: Journal Article,

Conversion of a homogeneously methicillin-resistant strain of Staphylococcus aureus to heterogeneous resistance by Tn551-mediated insertional inactivation
Kornblum J; Hartman BJ; Novick RP; Tomasz A
1986 Dec;5(6):714-718, European Journal of clinical microbiology
— id: 63944, year: 1986, vol: 5, page: 714, stat: Journal Article,

Nosocomial transmission of a strain of Staphylococcus aureus causing toxic shock syndrome
Kreiswirth BN; Kravitz GR; Schlievert PM; Novick RP
1986 Nov;105(5):704-707, Annals of internal medicine
— id: 63947, year: 1986, vol: 105, page: 704, stat: Journal Article,

Antibiotic resistance genes : ecology, transfer, and expression
Levy, Stuart B.; Novick, Richard P
Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory, 1986,
— id: 60, year: 1986, vol: , page: , stat: ,

RepC is rate limiting for pT181 plasmid replication
Manch-Citron JN; Gennaro ML; Majumder S; Novick RP
1986 Sep;16(2):108-115, Plasmid
— id: 63949, year: 1986, vol: 16, page: 108, stat: Journal Article,

Small Staphylococcus aureus plasmids are transduced as linear multimers that are formed and resolved by replicative processes
Novick RP; Edelman I; Lofdahl S
1986 Nov 20;192(2):209-220, Journal of molecular biology
— id: 63946, year: 1986, vol: 192, page: 209, stat: Journal Article,

Incompatibility between plasmids with independent copy control
Projan SJ; Novick RP
1986 Aug;204(2):341-348, Molecular & general genetics
— id: 63950, year: 1986, vol: 204, page: 341, stat: Journal Article,

Regulation of exoprotein gene expression in Staphylococcus aureus by agar
Recsei P; Kreiswirth B; O'Reilly M; Schlievert P; Gruss A; Novick RP
1986 Jan;202(1):58-61, Molecular & general genetics
— id: 63952, year: 1986, vol: 202, page: 58, stat: Journal Article,

Expression of the cloned toxic shock syndrome toxin 1 gene (tst) in vivo with a rabbit uterine model
de Azavedo JC; Foster TJ; Hartigan PJ; Arbuthnott JP; O'Reilly M; Kreiswirth BN; Novick RP
1985 Oct;50(1):304-309, Infection & immunity
— id: 63953, year: 1985, vol: 50, page: 304, stat: Journal Article,

Plasmid pT181 replication is regulated by two countertranscripts
Kumar CC; Novick RP
1985 Feb;82(3):638-642, Proceedings of the National Academy of Sciences of the United States of America
— id: 63955, year: 1985, vol: 82, page: 638, stat: Journal Article,

MLS-resistance determinants in Staphylococcus aureus and their molecular evolution
Novick RP; Murphy E
1985 Jul;16 Suppl A:101-110, Journal of antimicrobial chemotherapy
— id: 63954, year: 1985, vol: 16 Suppl A, page: 101, stat: Journal Article,

Replication control for pT181, an indirectly regulated plasmid
Novick RP; Projan SJ; Kumar CC; Carleton S; Gruss A; Highlander SK; Kornblum J
1985 ;30:299-320, Basic life sciences
— id: 63957, year: 1985, vol: 30, page: 299, stat: Journal Article,

Comparative sequence and functional analysis of pT181 and pC221, cognate plasmid replicons from Staphylococcus aureus
Projan SJ; Kornblum J; Moghazeh SL; Edelman I; Gennaro ML; Novick RP
1985 ;199(3):452-464, Molecular & general genetics
— id: 63956, year: 1985, vol: 199, page: 452, stat: Journal Article,

Staphylococcal enterotoxin A gene is associated with a variable genetic element
Betley MJ; Lofdahl S; Kreiswirth BN; Bergdoll MS; Novick RP
1984 Aug;81(16):5179-5183, Proceedings of the National Academy of Sciences of the United States of America
— id: 63960, year: 1984, vol: 81, page: 5179, stat: Journal Article,

Control of pT181 replication II. Mutational analysis
Carleton S; Projan SJ; Highlander SK; Moghazeh SM; Novick RP
1984 Oct;3(10):2407-2414, EMBO journal
— id: 63959, year: 1984, vol: 3, page: 2407, stat: Journal Article,

Genetic characterization and cloning of the toxic shock syndrome exotoxin
Kreiswirth BN; O'Reilly M; Novick RP
1984 ;3(1):73-82, Survey & synthesis of pathology research
— id: 63962, year: 1984, vol: 3, page: 73, stat: Journal Article,

Control of pT181 replication I. The pT181 copy control function acts by inhibiting the synthesis of a replication protein
Novick RP; Adler GK; Projan SJ; Carleton S; Highlander SK; Gruss A; Khan SA; Iordanescu S
1984 Oct;3(10):2399-2405, EMBO journal
— id: 63958, year: 1984, vol: 3, page: 2399, stat: Journal Article,

Staphylococcal plasmid cointegrates are formed by host- and phage-mediated general rec systems that act on short regions of homology
Novick RP; Projan SJ; Rosenblum W; Edelman I
1984 ;195(1-2):374-377, Molecular & general genetics
— id: 63963, year: 1984, vol: 195, page: 374, stat: Journal Article,

Reciprocal intrapool variation in plasmid copy numbers: a characteristic of segregational incompatibility
Projan SJ; Novick RP
1984 Jul;12(1):52-60, Plasmid
— id: 63961, year: 1984, vol: 12, page: 52, stat: Journal Article,

Effects of tylosin feeding on the antibiotic resistance of selected gram-positive bacteria in pigs
Christie PJ; Davidson JN; Novick RP; Dunny GM
1983 Jan;44(1):126-128, American journal of veterinary research
— id: 63967, year: 1983, vol: 44, page: 126, stat: Journal Article,

Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus
Khan SA; Novick RP
1983 Nov;10(3):251-259, Plasmid
— id: 63964, year: 1983, vol: 10, page: 251, stat: Journal Article,

The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage
Kreiswirth BN; Lofdahl S; Betley MJ; O'Reilly M; Schlievert PM; Bergdoll MS; Novick RP
1983 Oct 20-26;305(5936):709-712, Nature
— id: 63965, year: 1983, vol: 305, page: 709, stat: Journal Article,

Determination of plasmid copy number by fluorescence densitometry
Projan SJ; Carleton S; Novick RP
1983 Mar;9(2):182-190, Plasmid
— id: 63966, year: 1983, vol: 9, page: 182, stat: Journal Article,

Functional origin of replication of pT181 plasmid DNA is contained within a 168-base-pair segment
Khan SA; Adler GK; Novick RP
1982 Aug;79(15):4580-4584, Proceedings of the National Academy of Sciences of the United States of America
— id: 63968, year: 1982, vol: 79, page: 4580, stat: Journal Article,

Structural analysis of plasmid pSN2 in Staphylococcus aureus: no involvement in enterotoxin B production
Khan SA; Novick RP
1982 Feb;149(2):642-649, Journal of bacteriology
— id: 63972, year: 1982, vol: 149, page: 642, stat: Journal Article,

Genetic studies on Staphylococcal strains from patients with toxic shock syndrome
Kreiswirth BN; Novick RP; Schlievert PM; Bergdoll M
1982 Jun;96(6 Pt 2):974-977, Annals of internal medicine
— id: 63970, year: 1982, vol: 96, page: 974, stat: Journal Article,

Coding sequence for the pT181 repC product: a plasmid-coded protein uniquely required for replication
Novick RP; Adler GK; Majumder S; Khan SA; Carleton S; Rosenblum WD; Iordanescu S
1982 Jul;79(13):4108-4112, Proceedings of the National Academy of Sciences of the United States of America
— id: 63969, year: 1982, vol: 79, page: 4108, stat: Journal Article,

Closely related plasmids from Staphylococcus aureus and soil bacilli
Polak J; Novick RP
1982 Mar;7(2):152-162, Plasmid
— id: 63971, year: 1982, vol: 7, page: 152, stat: Journal Article,

Replication of plasmid pT181 DNA in vitro: requirement for a plasmid-encoded product
Khan SA; Carleton SM; Novick RP
1981 Aug;78(8):4902-4906, Proceedings of the National Academy of Sciences of the United States of America
— id: 63974, year: 1981, vol: 78, page: 4902, stat: Journal Article,

Site-specificity of the chromosomal insertion of Staphylococcus aureus transposon Tn554
Krolewski JJ; Murphy E; Novick RP; Rush MG
1981 Oct 15;152(1):19-33, Journal of molecular biology
— id: 17451, year: 1981, vol: 152, page: 19, stat: Journal Article,

Tn554: isolation and characterization of plasmid insertions
Murphy E; Phillips S; Edelman I; Novick RP
1981 May;5(3):292-305, Plasmid
— id: 63976, year: 1981, vol: 5, page: 292, stat: Journal Article,

The development and spread of antibiotic-resistant bacteria as a consequence of feeding antibiotics to livestock
Novick RP
1981 ;368:23-59, Annals of the New York Academy of Sciences
— id: 63977, year: 1981, vol: 368, page: 23, stat: Journal Article,

Transduction-related cointegrate formation between Staphylococcal plasmids: a new type of site-specific recombination
Novick RP; Iordanescu S; Surdeanu M; Edelman I
1981 Sep;6(2):159-172, Plasmid
— id: 63973, year: 1981, vol: 6, page: 159, stat: Journal Article,

Hitchhiking transposons and other mobile genetic elements and site-specific recombination systems in Staphylococcus aureus
Novick RP; Khan SA; Murphy E; Iordanescu S; Edelman I; Krolewski J; Rush M
1981 ;45 Pt 1:67-76, Cold Spring Harbor symposia on quantitative biology
— id: 63978, year: 1981, vol: 45 Pt 1, page: 67, stat: Journal Article,

Inducible plasmid-determined resistance to arsenate, arsenite, and antimony (III) in escherichia coli and Staphylococcus aureus
Silver S; Budd K; Leahy KM; Shaw WV; Hammond D; Novick RP; Willsky GR; Malamy MH; Rosenberg H
1981 Jun;146(3):983-996, Journal of bacteriology
— id: 63975, year: 1981, vol: 146, page: 983, stat: Journal Article,

Epidemiological and structural studies of Staphylococcus aureus R plasmids mediating resistance to tobramycin and streptogramin
el Solh N; Fouace JM; Shalita Z; Bouanchaud DH; Novick RP; Chabbert YA
1980 Jul;4(1):117-120, Plasmid
— id: 63981, year: 1980, vol: 4, page: 117, stat: Journal Article,

Terminal nucleotide sequences of Tn551, a transposon specifying erythromycin resistance in Staphylococcus aureus: homology with Tn3
Khan SA; Novick RP
1980 Sep;4(2):148-154, Plasmid
— id: 63980, year: 1980, vol: 4, page: 148, stat: Journal Article,

Site-specific recombination between plasmids of Staphylococcus aureus
Murphy E; Novick RP
1980 Jan;141(1):316-326, Journal of bacteriology
— id: 63983, year: 1980, vol: 141, page: 316, stat: Journal Article,

Plasmids
Novick RP
1980 Dec;243(6):'111'-'119', Scientific american
— id: 63979, year: 1980, vol: 243, page: '111', stat: Journal Article,

Penicillinase plasmids of Staphylococcus aureus: structural and evolutionary relationships
Shalita Z; Murphy E; Novick RP
1980 May;3(3):291-311, Plasmid
— id: 63982, year: 1980, vol: 3, page: 291, stat: Journal Article,

Nomenclature of transposable elements in prokaryotes
Campbell A; Berg DE; Botstein D; Lederberg EM; Novick RP; Starlinger P; Szybalski W
1979 Mar;5(3):197-206, Gene
— id: 63987, year: 1979, vol: 5, page: 197, stat: Journal Article,

Nomenclature of transposable elements in prokaryotes
Campbell A; Starlinger P; Berg DE; Botstein D; Lederberg EM; Novick RP; Szybalski W
1979 Jul;2(3):466-473, Plasmid
— id: 63985, year: 1979, vol: 2, page: 466, stat: Journal Article,

Physical mapping of Staphylococcus aureus penicillinase plasmid pI524: characterization of an invertible region
Murphy E; Novick RP
1979 Aug;175(1):19-30, Molecular & general genetics
— id: 63984, year: 1979, vol: 175, page: 19, stat: Journal Article,

The molecular basis of the plasmid state
Novick RP
1979 ;6:1-15, Contributions to microbiology & immunology
— id: 63989, year: 1979, vol: 6, page: 1, stat: Journal Article,

Translocatable elements in Staphylococcus aureus
Novick RP; Edelman I; Latta PD; Swanson EC; Pattee PA
1979 ;6:41-55, Contributions to microbiology & immunology
— id: 63988, year: 1979, vol: 6, page: 41, stat: Journal Article,

Genetic translocation in Staphylococcus aureus
Novick RP; Edelman I; Schwesinger MD; Gruss AD; Swanson EC; Pattee PA
1979 Jan;76(1):400-404, Proceedings of the National Academy of Sciences of the United States of America
— id: 63991, year: 1979, vol: 76, page: 400, stat: Journal Article,

Penicillinase plasmids of Staphylococcus aureus: restriction-deletion maps
Novick RP; Murphy E; Gryczan TJ; Baron E; Edelman I
1979 Jan;2(1):109-129, Plasmid
— id: 63990, year: 1979, vol: 2, page: 109, stat: Journal Article,

Tn554--a site-specific repressor-controlled transposon in Staphylococcus aureus
Phillips S; Novick RP
1979 Mar 29;278(5703):476-478, Nature
— id: 63986, year: 1979, vol: 278, page: 476, stat: Journal Article,

Partition kinetics and thermosensitive replication of pT169, a naturally occurring multicopy tetracycline resistance plasmid of Staphylococcus aureus
Della Latta P; Bouanchaud D; Novick RP
1978 Jun;1(3):366-375, Plasmid
— id: 63993, year: 1978, vol: 1, page: 366, stat: Journal Article,

Incompatibility and molecular relationships between small Staphylococcal plasmids carrying the same resistance marker
Iordanescu, S; Surdeanu, M; Della Latta, P; Novick, R
1978 Sep;1(4):468-479, Plasmid
— id: 886222, year: 1978, vol: 1, page: 468, stat: Journal Article,

On plasmid incompatibility
Novick RP; Hoppensteadt FC
1978 Sep;1(4):421-434, Plasmid
— id: 63992, year: 1978, vol: 1, page: 421, stat: Journal Article,

The mechanism of translocation in bacteria
Novick RP
1977 May 12-20;(29):272-276, Brookhaven symposia on biology
— id: 63995, year: 1977, vol: , page: 272, stat: Journal Article,

Chromosomal map locations of integrated plasmids and related elements in Staphylococcus aureus
Pattee PA; Thompson NE; Haubrich D; Novick RP
1977 Nov;1(1):38-51, Plasmid
— id: 63994, year: 1977, vol: 1, page: 38, stat: Journal Article,

Uniform nomenclature for bacterial plasmids: a proposal
Novick RP; Clowes RC; Cohen SN; Curtiss R 3rd; Datta N; Falkow S
1976 Mar;40(1):168-189, Bacteriological reviews
— id: 63997, year: 1976, vol: 40, page: 168, stat: Journal Article,

Indepencence of plasmid incompatibility and replication control functions in Staphylococcus aureus
Novick RP; Schwesinger M
1976 Aug 12;262(5569):623-626, Nature
— id: 63996, year: 1976, vol: 262, page: 623, stat: Journal Article,

Nucleic acid hybridization analysis of an integrated plasmid in Staphylococcus aureus
Novick R; Zouzias D; Rush M
1975 Dec;124(3):1424-1428, Journal of bacteriology
— id: 17084, year: 1975, vol: 124, page: 1424, stat: Journal Article,

Plasmid interactions in Staphylococcus aureus: nonadditivity of compatible plasmid DNA pools
Ruby C; Novick RP
1975 Dec;72(12):5031-5035, Proceedings of the National Academy of Sciences of the United States of America
— id: 63998, year: 1975, vol: 72, page: 5031, stat: Journal Article,

DETECTION AND QUANTITATION OF STAPHYLOCOCCUS-AUREUS PENICILLINASE PLASMID DEOXYRIBONUCLEIC-ACID BY REASSOCIATION KINETICS
Rush, M; Novick, R; Delap, R
1975 ;124(3):1417-1423, Journal of bacteriology
— id: 29435, year: 1975, vol: 124, page: 1417, stat: Journal Article,

Prophage-dependent plasmid integration in Staphylococcus aureus
Schwesinger MD; Novick RP
1975 Aug;123(2):724-738, Journal of bacteriology
— id: 63999, year: 1975, vol: 123, page: 724, stat: Journal Article,

Studies on plasmid replication. V Replicative intermediates
Sheehy RJ; Novick RP
1975 Apr 5;93(2):237-253, Journal of molecular biology
— id: 64000, year: 1975, vol: 93, page: 237, stat: Journal Article,

Studies on plasmid replication. III. Isolation and characterization of replication-defective mutants
Novick RP
1974 ;135(2):131-147, Molecular & general genetics
— id: 64003, year: 1974, vol: 135, page: 131, stat: Journal Article,

Genetic control of chromosomal and plasmid recombination in Staphylococcus aureus
Wyman L; Goering RV; Novick RP
1974 Apr;76(4):681-702, Genetics
— id: 64001, year: 1974, vol: 76, page: 681, stat: Journal Article,

Studies on plasmid replication. IV. Complementation of replication-defective mutants by an incompatibility-deficient plasmid
Wyman L; Novick RP
1974 ;135(2):149-161, Molecular & general genetics
— id: 64002, year: 1974, vol: 135, page: 149, stat: Journal Article,

Plasmid-specific transformation in Staphylococcus aureus
Lindberg M; Novick RP
1973 Jul;115(1):139-145, Journal of bacteriology
— id: 64005, year: 1973, vol: 115, page: 139, stat: Journal Article,

A catenated intermediate in plasmid replication
Novick RP; Smith K; Sheehy RJ; Murphy E
1973 Oct 15;54(4):1460-1469, Biochemical & biophysical research communications
— id: 64004, year: 1973, vol: 54, page: 1460, stat: Journal Article,

Studies on plasmid replication. II. In vivo transcription and its control in penicillinase plasmids from Staphylococcus aureus
Zouzias D; Rush M; Murphy E; Novick R
1973 Sep 25;79(3):471-480, Journal of molecular biology
— id: 17085, year: 1973, vol: 79, page: 471, stat: Journal Article,

Studies on plasmid replication. I. Plasmid incompatibility and establishment in Staphylococcus aureus
Novick RP; Brodsky R
1972 Jul 21;68(2):285-302, Journal of molecular biology
— id: 64007, year: 1972, vol: 68, page: 285, stat: Journal Article,

Genetic studies on plasmid-linked cadmium resistance in Staphylococcus aureus
Smith K; Novick RP
1972 Nov;112(2):761-772, Journal of bacteriology
— id: 64006, year: 1972, vol: 112, page: 761, stat: Journal Article,

The problems of drug-resistant pathogenic bacteria. Extrachromosomal nature of drug resistance in Staphylococcus aureus
Novick, R P; Bouanchaud, D
1971 Jun 11;182:279-294, Annals of the New York Academy of Sciences
— id: 64008, year: 1971, vol: 182, page: 279, stat: Journal Article,

Extrachromosomal inheritance in bacteria
Novick RP
1969 Jun;33(2):210-263, Bacteriological reviews
— id: 64009, year: 1969, vol: 33, page: 210, stat: Journal Article,

Staphylococcal plasmids
Novick RP
1969 Mar;55(3):3-3, Journal of general microbiology
— id: 64011, year: 1969, vol: 55, page: 3, stat: Journal Article,

Naturally occurring penicillinase plasmids in Staphylococcus aureus
Peyru G; Wexler LF; Novick RP
1969 Apr;98(1):215-221, Journal of bacteriology
— id: 64010, year: 1969, vol: 98, page: 215, stat: Journal Article,

Penicillinase plasmid DNA from Staphylococcus aureus
Rush MG; Gordon CN; Novick RP; Warner RC
1969 Aug;63(4):1304-1310, Proceedings of the National Academy of Sciences of the United States of America
— id: 17462, year: 1969, vol: 63, page: 1304, stat: Journal Article,

Plasmid-linked resistance to inorganic salts in Staphylococcus aureus
Novick RP; Roth C
1968 Apr;95(4):1335-1342, Journal of bacteriology
— id: 64013, year: 1968, vol: 95, page: 1335, stat: Journal Article,

Streptomycin suppression of plasmid-linked mutations in Staphylococcus aureus
Peyru G; Novick RP
1968 Nov;96(5):1863-1866, Journal of bacteriology
— id: 64012, year: 1968, vol: 96, page: 1863, stat: Journal Article,

Penicillinase plasmids of Staphylococcus aureus
Novick RP
1967 Jan-Feb;26(1):29-38, Federation proceedings (Federation of American Societies for Experimental Biology)
— id: 64015, year: 1967, vol: 26, page: 29, stat: Journal Article,

In vivo transmission of drug resistance factors between strains of Staphylococcus aureus
Novick RP; Morse SI
1967 Jan 1;125(1):45-59, Journal of experimental medicine
— id: 64014, year: 1967, vol: 125, page: 45, stat: Journal Article,

The genetic determinant of staphylococcal penicillinase
Novick RP
1965 Jul 23;128(1):165-182, Annals of the New York Academy of Sciences
— id: 64017, year: 1965, vol: 128, page: 165, stat: Journal Article,

NATURE AND INTERACTIONS OF THE GENETIC ELEMENTS GOVERNING PENICILLINASE SYNTHESIS IN STAPHYLOCOCCUS AUREUS
NOVICK RP; RICHMOND MH
1965 Aug;90:467-480, Journal of bacteriology
— id: 64016, year: 1965, vol: 90, page: 467, stat: Journal Article,

ANALYSIS BY TRANSDUCTION OF MUTATIONS AFFECTING PENICILLINASE FORMATION IN STAPHYLOCOCCUS AUREUS
NOVICK RP
1963 Oct;33:121-136, Journal of general microbiology
— id: 64018, year: 1963, vol: 33, page: 121, stat: Journal Article,

Micro-iodometric assay for penicillinase
NOVICK RP
1962 May;83:236-240, Biochemical journal
— id: 64020, year: 1962, vol: 83, page: 236, stat: Journal Article,

Staphylococcal penicillinase and the new penicillins
NOVICK RP
1962 May;83:229-235, Biochemical journal
— id: 64019, year: 1962, vol: 83, page: 229, stat: Journal Article,

Control by endogenously synthesized arginine of the formation of ornithine transcarbamylase in Escherichia coli
NOVICK RP; MAAS WK
1961 Feb;81:236-240, Journal of bacteriology
— id: 64021, year: 1961, vol: 81, page: 236, stat: Journal Article,