Benjamin G. Neel

Biosketch / Results /

Benjamin Neel

Professor, Department of Medicine
Director Laura & Isaac Perlmutter Cancer Center

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-3019
Benjamin.Neel@nyumc.org

Research Summary

As the director of Perlmutter Cancer Center, I lead a rigorous academic community of clinician–scientists and basic scientists, as well as a team of compassionate physicians who are dedicated to our patients. Through our clinical trials, we give patients unprecedented access to novel therapies and experimental treatments. I also oversee the advancement of our translational programs in immunotherapy, cancer genetics, targeted therapies, and epigenetics, as well as imaging, community outreach, and supportive oncology.

One of my goals as director is to foster collaboration between physicians and researchers. I create new opportunities for them to meaningfully engage with one another and form multidisciplinary partnerships. We have the best chance at dramatically impacting patient survival when we work together to understand the essence of cancer and its vulnerabilities, as well as the progress that has been made in cancer biology.

We’re at a historic time in the field — we finally understand a range of factors that cause cancer, from one’s environment to molecular defects in cancer cells. When I was a graduate student, we didn’t know a single gene mutation that causes cancer, nor did we understand cancer’s molecular basis. Now we know that different cancers are caused by different agents, and we have identified between 500 and 1,000 gene mutations that, in various combinations, can lead to cancer. With this knowledge, we have created a bevy of treatments that we can use against the disease, such as epigenetic therapy and immunotherapy.

My own research focuses on cell signaling in cancer and developmental disease, as well as the biology of breast and ovarian cancer. In addition to authoring more than 200 original papers, 25 reviews, and 2 books, I have received multiple grants from the National Institutes of Health and National Cancer Institute, as well as private foundations. I was the inaugural recipient of the Gertrude Elion Award of the American Association for Cancer Research, have held multiple named lectureships, and serve on editorial board of several journals, including Cancer Cell, Molecular Cell, and Cancer Discovery, among others. I am an elected member of the Association of American Physicians, a former member of the board of directors of the American Association for Cancer Research, and co-founder of Northern Biologics, a biotechnology company developing new therapies for cancer and fibrosis.

Research Keywords

cancer, genomics, stem cell biology

Cancer: Bad neighbours cause bad blood
Chan, Gordon; Neel, Benjamin G. Cancer: Bad neighbours cause bad blood. Nature. 2016 Nov 10;539(7628):173-175 (2332332)

Sticking It to Cancer with Molecular Glue for SHP2
Ran, Hao; Tsutsumi, Ryouhei; Araki, Toshiyuki; Neel, Benjamin G. Sticking It to Cancer with Molecular Glue for SHP2. Cancer cell. 2016 Aug 08;30(2):194-196 (2211692)

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
Banh, Robert S; Iorio, Caterina; Marcotte, Richard; Xu, Yang; Cojocari, Dan; Rahman, Anas Abdel; Pawling, Judy; Zhang, Wei; Sinha, Ankit; Rose, Christopher M; Isasa, Marta; Zhang, Shuang; Wu, Ronald; Virtanen, Carl; Hitomi, Toshiaki; Habu, Toshiyuki; Sidhu, Sachdev S; Koizumi, Akio; Wilkins, Sarah E; Kislinger, Thomas; Gygi, Steven P; Schofield, Christopher J; Dennis, James W; Wouters, Bradly G; Neel, Benjamin G. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nature cell biology. 2016 Jul;18(7):803-813 (2159072)

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1
Gu, Shengqing; Chan, Wayne W; Mohi, Golam; Rosenbaum, Joel; Sayad, Azin; Lu, Zhibin; Virtanen, Carl; Li, Shaoguang; Neel, Benjamin G; Van Etten, Richard A. Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. Blood. 2016 Apr 07;127(14):1803-1813 (2043182)

Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies
Liu, Xia; Zheng, Hong; Li, Xiaobo; Wang, Siying; Meyerson, Howard J; Yang, Wentian; Neel, Benjamin G; Qu, Cheng-Kui. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2016 Jan 26;113(4):984-989 (1909242)