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Jeremy NanceAssociate Professor, Department of Cell Biology
540-562 First Avenue
New York, NY 10016
Our lab uses the C. elegans embryo as a simple model to understand how cell interactions and movements shape the developing body plan. As in many organisms, cells in the early embryo polarize in response to cell-cell contacts. Polarity in early C. elegans cells provides a foundation for subsequent cytoskeletal asymmetries that direct the cell movements of gastrulation. Projects in the lab include:
- Understanding how cell contacts induce polarity in early embryonic cells. We have identified a signaling pathway that translates cell contact cues into cell polarity by regulating the spatial activity of RhoGTPases.
- Learning how gastrulation movements are triggered in specific cells. We have found that primordial germ cells utilize a unique hitchhiking mechanism, regulated by E-cadherin, which allows them to be pulled into the embryo during gastrulation.
- Uncovering how the various cell types of an organ assemble together. We have examined assembly of the primordial gonad as a simple model for organogenesis. The primordial gonad contains two germ cells and two somatic gonad cells, which undergo an elaborate assembly process that includes migration, stopping, pseudopod extension, and wrapping.
- Investigating how epithelial cells and tubes form during organogenesis. We have identified different roles for PAR-3 and PAR-6 in epithelial cell polarization and junction assembly, respectively, and have shown that PAR proteins cooperate with the vesicle tethering exocyst complex to regulate lumen formation in a single-celled tube.
Research InterestsCell polarity, gastrulation, and organogenesis in the C. elegans embryo
Research KeywordsC. elegans, embryogenesis, developmental biology, cell polarity, gastrulation, organogenesis, epithelial cells, germ cells
A combined binary interaction and phenotypic map of C. elegans cell polarity proteins
Koorman, Thijs; Klompstra, Diana; van der Voet, Monique; Lemmens, Irma; Ramalho, Joao J; Nieuwenhuize, Susan; van den Heuvel, Sander; Tavernier, Jan; Nance, Jeremy; Boxem, Mike. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Nature cell biology. 2016 Jan 18;18(3):337-346 (1922042)
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity
Klompstra, Diana; Anderson, Dorian C; Yeh, Justin Y; Zilberman, Yuliya; Nance, Jeremy. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nature cell biology. 2015 May 4;17(6):726-735 (1616322)
A novel germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans
Mainpal, Rana; Nance, Jeremy; Yanowitz, Judith L. A novel germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans. Development. 2015 Sep 22;142(20):3571-3582 (1786812)
The P4-ATPase TAT-5 inhibits the outward budding of the plasma membrane in C. elegans embryos
Wehman, AM; Nance, J. The P4-ATPase TAT-5 inhibits the outward budding of the plasma membrane in C. elegans embryos [Meeting Abstract]. FEBS journal. 2015 JUL;282:237-237 (1821912)
Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell
Armenti, Stephen T; Chan, Emily; Nance, Jeremy. Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell. Developmental biology (Orlando). 2014 Aug 4;394(1):110-121 (1209372)