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Jeremy NanceAssociate Professor, Department of Cell Biology
540-562 First Avenue
New York, NY 10016
Our lab uses the C. elegans embryo as a simple model to understand how cell interactions and movements shape the developing body plan. As in many organisms, cells in the early embryo polarize in response to cell-cell contacts. Polarity in early C. elegans cells provides a foundation for subsequent cytoskeletal asymmetries that direct the cell movements of gastrulation. Projects in the lab include:
- Understanding how cell contacts induce polarity in early embryonic cells. We have identified a signaling pathway that translates cell contact cues into cell polarity by regulating the spatial activity of RhoGTPases.
- Learning how gastrulation movements are triggered in specific cells. We have found that primordial germ cells utilize a unique hitchhiking mechanism, regulated by E-cadherin, which allows them to be pulled into the embryo during gastrulation.
- Uncovering how the various cell types of an organ assemble together. We have examined assembly of the primordial gonad as a simple model for organogenesis. The primordial gonad contains two germ cells and two somatic gonad cells, which undergo an elaborate assembly process that includes migration, stopping, pseudopod extension, and wrapping.
- Investigating how epithelial cells and tubes form during organogenesis. We have identified different roles for PAR-3 and PAR-6 in epithelial cell polarization and junction assembly, respectively, and have shown that PAR proteins cooperate with the vesicle tethering exocyst complex to regulate lumen formation in a single-celled tube.
Research InterestsCell polarity, gastrulation, and organogenesis in the C. elegans embryo
Research KeywordsC. elegans, embryogenesis, developmental biology, cell polarity, gastrulation, organogenesis, epithelial cells, germ cells, cancer, developmental genetics, genome integrity, stem cell biology
Developmentally programmed germ cell remodelling by endodermal cell cannibalism
Abdu, Yusuff; Maniscalco, Chelsea; Heddleston, John M; Chew, Teng-Leong; Nance, Jeremy. Developmentally programmed germ cell remodelling by endodermal cell cannibalism. Nature cell biology. 2016 Dec;18(12):1302-1310 (2310892)
Board Number: B1434 Regulation of cell shape change by local inhibition of CDC-42 at epithelial junctions
Zilberman, Y; Anderson, D; Nance, J. Board Number: B1434 Regulation of cell shape change by local inhibition of CDC-42 at epithelial junctions [Meeting Abstract]. Molecular biology of the cell. 2016 December;Conference:(Annual):4726- 4727 (2396752)
A combined binary interaction and phenotypic map of C. elegans cell polarity proteins
Koorman, Thijs; Klompstra, Diana; van der Voet, Monique; Lemmens, Irma; Ramalho, Joao J; Nieuwenhuize, Susan; van den Heuvel, Sander; Tavernier, Jan; Nance, Jeremy; Boxem, Mike. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Nature cell biology. 2016 Mar;18(3):337-346 (1922042)
A novel germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans
Mainpal, Rana; Nance, Jeremy; Yanowitz, Judith L. A novel germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans. Development. 2015 Oct 15;142(20):3571-3582 (1786812)
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity
Klompstra, Diana; Anderson, Dorian C; Yeh, Justin Y; Zilberman, Yuliya; Nance, Jeremy. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nature cell biology. 2015 Jun;17(6):726-735 (1616322)