Biosketch / Results /

Jeremy Nance

Associate Professor, Department of Cell Biology

Contact Info

Address
540-562 First Avenue
New York, NY 10016

212/263-3156
jeremy.nance@med.nyu.edu


Research Summary

Our lab uses the C. elegans embryo as a simple model to understand how cell interactions and movements shape the developing body plan.  As in many organisms, cells in the early embryo polarize in response to cell-cell contacts.  Polarity in early C. elegans cells provides a foundation for subsequent cytoskeletal asymmetries that direct the cell movements of gastrulation. Projects in the lab include:

 

  1. Understanding how cell contacts induce polarity in early embryonic cells.  We have identified a signaling pathway that translates cell contact cues into cell polarity by regulating the spatial activity of RhoGTPases.

 

  1. Learning how gastrulation movements are triggered in specific cells.   We have found that primordial germ cells utilize a unique hitchhiking mechanism, regulated by E-cadherin, which allows them to be pulled into the embryo during gastrulation. 

 

  1. Uncovering how the various cell types of an organ assemble together.  We have examined assembly of the primordial gonad as a simple model for organogenesis.  The primordial gonad contains two germ cells and two somatic gonad cells, which undergo an elaborate assembly process that includes migration, stopping, pseudopod extension, and wrapping. 

 

  1. Investigating how epithelial cells and tubes form during organogenesis.   We have identified different roles for PAR-3 and PAR-6 in epithelial cell polarization and junction assembly, respectively, and have shown that PAR proteins cooperate with the vesicle tethering exocyst complex to regulate lumen formation in a single-celled tube. 

Research Interests

Cell polarity, gastrulation, and organogenesis in the C. elegans embryo

Research Keywords

C. elegans, embryogenesis, developmental biology, cell polarity, gastrulation, organogenesis, epithelial cells, germ cells

A combined binary interaction and phenotypic map of C. elegans cell polarity proteins
Koorman, Thijs; Klompstra, Diana; van der Voet, Monique; Lemmens, Irma; Ramalho, Joao J; Nieuwenhuize, Susan; van den Heuvel, Sander; Tavernier, Jan; Nance, Jeremy; Boxem, Mike. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Nature cell biology. 2016 Jan 18;18(3):337-346 (1922042)

An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity
Klompstra, Diana; Anderson, Dorian C; Yeh, Justin Y; Zilberman, Yuliya; Nance, Jeremy. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nature cell biology. 2015 May 4;17(6):726-735 (1616322)

A novel germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans
Mainpal, Rana; Nance, Jeremy; Yanowitz, Judith L. A novel germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans. Development. 2015 Sep 22;142(20):3571-3582 (1786812)

The P4-ATPase TAT-5 inhibits the outward budding of the plasma membrane in C. elegans embryos
Wehman, AM; Nance, J. The P4-ATPase TAT-5 inhibits the outward budding of the plasma membrane in C. elegans embryos [Meeting Abstract]. FEBS journal. 2015 JUL;282:237-237 (1821912)

Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell
Armenti, Stephen T; Chan, Emily; Nance, Jeremy. Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell. Developmental biology (Orlando). 2014 Aug 4;394(1):110-121 (1209372)