Kathryn J. Moore

Biosketch / Results /

Kathryn J. Moore, Ph.D.

Professor;
Departments of Medicine (Cardio Div) and Cell Biology (Cell Biology)

Contact Info

Address
522 First Avenue
Floor 7 Room 705
Smilow Research Building
New York, NY 10016

212-263-9259
Kathryn.Moore@nyumc.org

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Education

1994 — McGill University, Graduate Education
1994-1996 — Harvard Medical School, Brigham and Women's Hospital, PostDoctoral Training
1996-2000 — Harvard Medical School, Massachusetts General Hospital, PostDoctoral Training

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Research Interests

The overall interest of the Moore Laboratory is to understand (1) the role of the innate immune system in sterile inflammatory conditions and host defense, and (2) the role of microRNAs in regulating lipoprotein metabolism and atherosclerosis. The innate immune system senses the presence of invading microorganisms and modified endogenous ligands by recognizing conserved molecular structures that are normally absent in the healthy host. Myeloid cells express classes of pattern recognition receptors, such as the scavenger receptors (SRs) and toll-like receptors (TLRs), that bind conserved a??non-selfa?? patterns to mediate this important function. Although often thought of as a broad, primitive defense mechanism, it is becoming increasingly clear that pattern recognition receptors can cooperate to precisely regulate signaling pathways essential for the proper initiation of innate and acquired immunity. However, the inappropriate activation of these receptors has also been linked to inflammatory syndromes, including atherosclerosis and Alzheimer's disease. MicroRNAs (miRNAs) represent an elegant mechanism of posttranscriptional control of gene expression that serves to fine-tune biological pathways. These tiny noncoding RNAs (20a??22 nucleotide) bind to the 3' untranslated region of mRNAs, thereby repressing gene expression. Recent advances in the understanding of lipid metabolism have revealed that miRNAs, particularly miR-33, play major roles in regulating cholesterol and fatty acid homeostasis. Work from our group identified miR-33, an intronic miRNA located with the sterol response element-binding protein (SREBP)-2 gene, as an important regulator of cellular cholesterol efflux, fatty acid I? oxidation, and high-density lipoprotein metabolism. Using inhibitors of miR-33, we showed in mice and non-human primates that antagonism of this microRNA increases plasma HDL and reduces VLDL triglycerides. These findings have highlighted the important role that miRNAs play in lipoprotein metabolism and opened new avenues for the treatment of dyslipidemias.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

A regulator of secretory vesicle size, kelch-like protein 12, facilitates the secretion of apolipoprotein b100 and very-low-density lipoproteins--brief report
Butkinaree, Chutikarn; Guo, Liang; Ramkhelawon, Bhama; Wanschel, Amarylis; Brodsky, Jeffrey L; Moore, Kathryn J; Fisher, Edward A
2014 Feb;34(2):251-254, Arteriosclerosis, thrombosis, & vascular biology
— id: 740952, year: 2014, vol: 34, page: 251, stat: Journal Article,

High-density lipoproteins put out the fire
Moore, Kathryn J; Fisher, Edward A
2014 Feb;19(2):175-176, Cell metabolism
— id: 806952, year: 2014, vol: 19, page: 175, stat: Journal Article,

Commentary on Fatty Acid wars: the diffusionists versus the translocatists
Pownall, Henry; Moore, Kathryn
2014 May;34(5):e8-e9, Arteriosclerosis, thrombosis, & vascular biology
— id: 881842, year: 2014, vol: 34, page: e8, stat: Journal Article,

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Ramkhelawon, Bhama; Hennessy, Elizabeth J; Menager, Mickael; Ray, Tathagat Dutta; Sheedy, Frederick J; Hutchison, Susan; Wanschel, Amarylis; Oldebeken, Scott; Geoffrion, Michele; Spiro, Westley; Miller, George; McPherson, Ruth; Rayner, Katey J; Moore, Kathryn J
2014 Apr;20(4):377-384, Nature medicine
— id: 881742, year: 2014, vol: 20, page: 377, stat: Journal Article,

MicroRNA control of high-density lipoprotein metabolism and function
Rayner, Katey J; Moore, Kathryn J
2014 Jan;114(1):183-192, Circulation research
— id: 806862, year: 2014, vol: 114, page: 183, stat: Journal Article,

Induction of neural guidance molecule expression in macrophages and dendritic cells by Mycobacterium tuberculosis
Bracho-Sanchez, Edith; Ramkhelawon, Bhama; Desvignes, Ludovic; Moore, Kathryn; Ernst, Joel
2013 MAY 1;190:-, Journal of immunology
— id: 540702, year: 2013, vol: 190, page: , stat: Journal Article,

Using microRNA as an Alternative Treatment for Hyperlipidemia and Cardiovascular Disease: Cardio-miRs in the Pipeline
Hennessy, Elizabeth J; Moore, Kathryn J
2013 Sep;62(3):247-254, Journal of cardiovascular pharmacology
— id: 529022, year: 2013, vol: 62, page: 247, stat: Journal Article,

Anti-miR33 Therapy Induces PGC1a Expression to Regulate Immunometabolic Pathways in Atherosclerosis and Obesity
Karunakaran, Denuja; Thrush, ABrianne; Wu, Zongbin; Geoffrion, Michele; Ramphos, Eleni; Moore, Kathryn J; Harper, Mary-Ellen; Rayner, Katey J
2013 NOV 26;128(22):?-?, Circulation
— id: 1004062, year: 2013, vol: 128, page: ?, stat: Journal Article,

Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics
Kim, Yongtae; Fay, Francois; Cormode, David P; Sanchez-Gaytan, Brenda L; Tang, Jun; Hennessy, Elizabeth J; Ma, Mingming; Moore, Kathryn; Farokhzad, Omid C; Fisher, Edward Allen; Mulder, Willem J M; Langer, Robert; Fayad, Zahi A
2013 Nov;7(11):9975-9983, ACS nano
— id: 700562, year: 2013, vol: 7, page: 9975, stat: Journal Article,

Netrin1 Is a Critical Autocrine Factor For Osteoclast Differentiation
Mediero, Aranzazu ; Ramkhelawon, Bhama ; Moore, Kathryn ; Purdue, P. Edward ; Goldring, Steven R. ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S1165-S1166, Arthritis & rheumatism
— id: 657212, year: 2013, vol: 65 10 10, page: S1165, stat: Journal Article,

microRNAs: small regulators with a big impact on lipid metabolism
Moore, Kathryn J
2013 May;54(5):1159-1160, Journal of lipid research
— id: 287242, year: 2013, vol: 54, page: 1159, stat: Journal Article,

Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease
Moore, Kathryn J; Fisher, Edward A
2013 Apr;38(4):628-630, Immunity
— id: 348682, year: 2013, vol: 38, page: 628, stat: Journal Article,

Macrophages in atherosclerosis: a dynamic balance
Moore, Kathryn J; Sheedy, Frederick J; Fisher, Edward A
2013 Oct;13(10):709-721, Nature reviews. Immunology
— id: 542752, year: 2013, vol: 13, page: 709, stat: Journal Article,

A big role for small RNAs in HDL homeostasis
Ouimet, Mireille; Moore, Kathryn J
2013 May;54(5):1161-1167, Journal of lipid research
— id: 287262, year: 2013, vol: 54, page: 1161, stat: Journal Article,

Hypoxia induces netrin-1 and unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival
Ramkhelawon, Bhama; Yang, Yuan; van Gils, Janine M; Hewing, Bernd; Rayner, Katey J; Parathath, Sajesh; Guo, Liang; Oldebeken, Scott; Feig, Jessica L; Fisher, Edward A; Moore, Kathryn J
2013 Jun;33(6):1180-1188, Arteriosclerosis, thrombosis, & vascular biology
— id: 346492, year: 2013, vol: 33, page: 1180, stat: Journal Article,

The Semaphorin 3E/PlexinD1 Axis Regulates Macrophage Inflammation in Obesity
Schmidt, Ann Marie; Moore, Kathryn J
2013 Oct;18(4):461-462, Cell metabolism
— id: 574092, year: 2013, vol: 18, page: 461, stat: Journal Article,

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
Sheedy, Frederick J; Grebe, Alena; Rayner, Katey J; Kalantari, Parisa; Ramkhelawon, Bhama; Carpenter, Susan B; Becker, Christine E; Ediriweera, Hasini N; Mullick, Adam E; Golenbock, Douglas T; Stuart, Lynda M; Latz, Eicke; Fitzgerald, Katherine A; Moore, Kathryn J
2013 Aug;14(8):812-820, Nature immunology
— id: 458672, year: 2013, vol: 14, page: 812, stat: Journal Article,

IL-1 signaling in atherosclerosis: sibling rivalry
Sheedy, Frederick J; Moore, Kathryn J
2013 Oct;14(10):1030-1032, Nature immunology
— id: 575802, year: 2013, vol: 14, page: 1030, stat: Journal Article,

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
Sokolovska, Anna; Becker, Christine E; Ip, W K Eddie; Rathinam, Vijay A K; Brudner, Matthew; Paquette, Nicholas; Tanne, Antoine; Vanaja, Sivapriya K; Moore, Kathryn J; Fitzgerald, Katherine A; Lacy-Hulbert, Adam; Stuart, Lynda M
2013 Jun;14(6):543-553, Nature immunology
— id: 366452, year: 2013, vol: 14, page: 543, stat: Journal Article,

Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions
van Gils, Janine M; Ramkhelawon, Bhama; Fernandes, Luciana; Stewart, Merran C; Guo, Liang; Seibert, Tara; Menezes, Gustavo B; Cara, Denise C; Chow, Camille; Kinane, T Bernard; Fisher, Edward A; Balcells, Mercedes; Alvarez-Leite, Jacqueline; Lacy-Hulbert, Adam; Moore, Kathryn J
2013 May;33(5):911-919, Arteriosclerosis, thrombosis, & vascular biology
— id: 287172, year: 2013, vol: 33, page: 911, stat: Journal Article,

Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein
Vickers, Kasey C; Moore, Kathryn J
2013 Nov;113(11):1189-1191, Circulation research
— id: 626822, year: 2013, vol: 113, page: 1189, stat: Journal Article,

Neuroimmune Guidance Cue Semaphorin 3E Is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention
Wanschel, Amarylis; Seibert, Tara; Hewing, Bernd; Ramkhelawon, Bhama; Ray, Tathagat D; van Gils, Janine M; Rayner, Katey J; Feig, Jonathan E; O'Brien, Edward R; Fisher, Edward A; Moore, Kathryn J
2013 May;33(5):886-893, Arteriosclerosis, thrombosis, & vascular biology
— id: 287182, year: 2013, vol: 33, page: 886, stat: Journal Article,

HDL and Cardiovascular Risk: Time to Call the Plumber?
Hewing, Bernd; Moore, Kathryn J; Fisher, Edward A
2012 Oct;111(9):1117-1120, Circulation research
— id: 180095, year: 2012, vol: 111, page: 1117, stat: Journal Article,

miR-33: A Therapeutic Target for Cardiometabolic Diseases
Moore, Kathryn
2012 DEC;22(6):A9-A9, Nucleic acid therapeutics
— id: 208122, year: 2012, vol: 22, page: A9, stat: Journal Article,

The double-edged sword of fibronectin in atherosclerosis
Moore, Kathryn J; Fisher, Edward A
2012 Jul;4(7):561-563, EMBO molecular medicine
— id: 171126, year: 2012, vol: 4, page: 561, stat: Journal Article,

MicroRNAs regulating lipid metabolism in atherogenesis
Rayner, K J; Fernandez-Hernando, C; Moore, K J
2012 Apr;107(4):642-647, Thrombosis & haemostasis
— id: 166813, year: 2012, vol: 107, page: 642, stat: Journal Article,

The Plaque "Micro" Environment: microRNAs Control the Risk and the Development of Atherosclerosis
Rayner, Katey J; Moore, Kathryn J
2012 Oct;14(5):413-421, Current atherosclerosis reports
— id: 178054, year: 2012, vol: 14, page: 413, stat: Journal Article,

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
van Gils JM; Derby MC; Fernandes LR; Ramkhelawon B; Ray TD; Rayner KJ; Parathath S; Distel E; Feig JL; Alvarez-Leite JI; Rayner AJ; McDonald TO; O'Brien KD; Stuart LM; Fisher EA; Lacy-Hulbert A; Moore KJ
2012 ;13(2):136-143, Nature immunology
— id: 149862, year: 2012, vol: 13, page: 136, stat: Journal Article,

Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells
Brundert, May; Heeren, Joerg; Merkel, Martin; Carambia, Antonella; Herkel, Johannes; Groitl, Peter; Dobner, Thomas; Ramakrishnan, Rajasekhar; Moore, Kathryn J; Rinninger, Franz
2011 Apr;52(4):745-758, Journal of lipid research
— id: 134207, year: 2011, vol: 52, page: 745, stat: Journal Article,

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Davalos, Alberto; Goedeke, Leigh; Smibert, Peter; Ramirez, Cristina M; Warrier, Nikhil P; Andreo, Ursula; Cirera-Salinas, Daniel; Rayner, Katey; Suresh, Uthra; Pastor-Pareja, Jose Carlos; Esplugues, Enric; Fisher, Edward A; Penalva, Luiz O F; Moore, Kathryn J; Suarez, Yajaira; Lai, Eric C; Fernandez-Hernando, Carlos
2011 May 31;108(22):9232-9237, Proceedings of the National Academy of Sciences of the United States of America
— id: 133351, year: 2011, vol: 108, page: 9232, stat: Journal Article,

HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells
Feig, Jonathan E; Rong, James X; Shamir, Raanan; Sanson, Marie; Vengrenyuk, Yuliya; Liu, Jianhua; Rayner, Katey; Moore, Kathryn; Garabedian, Michael; Fisher, Edward A
2011 Apr 26;108(17):7166-7171, Proceedings of the National Academy of Sciences of the United States of America
— id: 131816, year: 2011, vol: 108, page: 7166, stat: Journal Article,

MicroRNA Modulation of Cholesterol Homeostasis
Fernandez-Hernando, Carlos; Moore, Kathryn J
2011 Nov;31(11):2378-2382, Arteriosclerosis, thrombosis, & vascular biology
— id: 139482, year: 2011, vol: 31, page: 2378, stat: Journal Article,

MicroRNAs in lipid metabolism
Fernandez-Hernando, Carlos; Suarez, Yajaira; Rayner, Katey J; Moore, Kathryn J
2011 Apr;22(2):86-92, Current opinion in lipidology
— id: 128788, year: 2011, vol: 22, page: 86, stat: Journal Article,

Therapeutic targeting of micrornas
Gibson, N W; Bhat, B; Esau, C C; Davis, S; Tay, J; Marcusson, E; Chen, H; Jackson, A L; Karlsson, L; Moore, K J; Goga, A
2011 October 2011;21(5):A54-A54, Nucleic acid therapeutics
— id: 164446, year: 2011, vol: 21, page: A54, stat: Journal Article,

Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice
Higashimori, Mie; Tatro, Jeffrey B; Moore, Kathryn J; Mendelsohn, Michael E; Galper, Jonas B; Beasley, Debbie
2011 Jan;31(1):50-57, Arteriosclerosis, thrombosis, & vascular biology
— id: 138239, year: 2011, vol: 31, page: 50, stat: Journal Article,

The role of microRNAs in cholesterol efflux and hepatic lipid metabolism
Moore, Kathryn J; Rayner, Katey J; Suarez, Yajaira; Fernandez-Hernando, Carlos
2011 Aug 21;31:49-63, Annual review of nutrition
— id: 138339, year: 2011, vol: 31, page: 49, stat: Journal Article,

Macrophages in the pathogenesis of atherosclerosis
Moore, Kathryn J; Tabas, Ira
2011 Apr 29;145(3):341-355, Cell
— id: 131965, year: 2011, vol: 145, page: 341, stat: Journal Article,

MyD88 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4
Owens, A Phillip 3rd; Rateri, Debra L; Howatt, Deborah A; Moore, Kathryn J; Tobias, Peter S; Curtiss, Linda K; Lu, Hong; Cassis, Lisa A; Daugherty, Alan
2011 Dec;31(12):2813-2819, Arteriosclerosis, thrombosis, & vascular biology
— id: 146013, year: 2011, vol: 31, page: 2813, stat: Journal Article,

Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling
Pagler, Tamara A; Wang, Mi; Mondal, Mousumi; Murphy, Andrew J; Westerterp, Marit; Moore, Kathryn J; Maxfield, Frederick R; Tall, Alan R
2011 Jan 21;108(2):194-200, Circulation research
— id: 134118, year: 2011, vol: 108, page: 194, stat: Journal Article,

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner, Katey J; Esau, Christine C; Hussain, Farah N; McDaniel, Allison L; Marshall, Stephanie M; van Gils, Janine M; Ray, Tathagat D; Sheedy, Frederick J; Goedeke, Leigh; Liu, Xueqing; Khatsenko, Oleg G; Kaimal, Vivek; Lees, Cynthia J; Fernandez-Hernando, Carlos; Fisher, Edward A; Temel, Ryan E; Moore, Kathryn J
2011 Oct 20;478(7369):404-407, Nature
— id: 139483, year: 2011, vol: 478, page: 404, stat: Journal Article,

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
Rayner, Katey J; Sheedy, Frederick J; Esau, Christine C; Hussain, Farah N; Temel, Ryan E; Parathath, Saj; van Gils, Janine M; Rayner, Alistair J; Chang, Aaron N; Suarez, Yajaira; Fernandez-Hernando, Carlos; Fisher, Edward A; Moore, Kathryn J
2011 Jul 1;121(7):2921-2931, Journal of clinical investigation
— id: 136939, year: 2011, vol: 121, page: 2921, stat: Journal Article,

A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36
Wilkinson, Kim; Boyd, Justin D; Glicksman, Marcie; Moore, Kathryn J; El Khoury, Joseph
2011 Oct 7;286(40):34914-34922, Journal of biological chemistry
— id: 146015, year: 2011, vol: 286, page: 34914, stat: Journal Article,

Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence
Abrams, P; Andersson, K E; Birder, L; Brubaker, L; Cardozo, L; Chapple, C; Cottenden, A; Davila, W; de Ridder, D; Dmochowski, R; Drake, M; Dubeau, C; Fry, C; Hanno, P; Smith, J Hay; Herschorn, S; Hosker, G; Kelleher, C; Koelbl, H; Khoury, S; Madoff, R; Milsom, I; Moore, K; Newman, D; Nitti, V; Norton, C; Nygaard, I; Payne, C; Smith, A; Staskin, D; Tekgul, S; Thuroff, J; Tubaro, A; Vodusek, D; Wein, A; Wyndaele, J J
2010 ;29(1):213-240, Neurourology & urodynamics
— id: 157394, year: 2010, vol: 29, page: 213, stat: Journal Article,

Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
Bieghs, Veerle; Wouters, Kristiaan; van Gorp, Patrick J; Gijbels, Marion J J; de Winther, Menno P J; Binder, Christoph J; Lutjohann, Dieter; Febbraio, Maria; Moore, Kathryn J; van Bilsen, Marc; Hofker, Marten H; Shiri-Sverdlov, Ronit
2010 Jun;138(7):2474-2485, Gastroenterology
— id: 146014, year: 2010, vol: 138, page: 2474, stat: Journal Article,

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, Peter; Kono, Hajime; Rayner, Katey J; Sirois, Cherilyn M; Vladimer, Gregory; Bauernfeind, Franz G; Abela, George S; Franchi, Luigi; Nunez, Gabriel; Schnurr, Max; Espevik, Terje; Lien, Egil; Fitzgerald, Katherine A; Rock, Kenneth L; Moore, Kathryn J; Wright, Samuel D; Hornung, Veit; Latz, Eicke
2010 Apr 29;464(7293):1357-1361, Nature
— id: 109840, year: 2010, vol: 464, page: 1357, stat: Journal Article,

Phagocytosis and Phagosome Acidification Are Required for Pathogen Processing and MyD88-Dependent Responses to Staphylococcus aureus
Ip, W K Eddie; Sokolovska, Anna; Charriere, Guillaume M; Boyer, Laurent; Dejardin, Stephanie; Cappillino, Michael P; Yantosca, L Michael; Takahashi, Kazue; Moore, Kathryn J; Lacy-Hulbert, Adam; Stuart, Lynda M
2010 Jun 15;184(12):7071-7081, Journal of immunology
— id: 109839, year: 2010, vol: 184, page: 7071, stat: Journal Article,

microRNAs and cholesterol metabolism
Moore, Kathryn J; Rayner, Katey J; Suarez, Yajaira; Fernandez-Hernando, Carlos
2010 Dec;21(12):699-706, Trends in endocrinology & metabolism
— id: 138240, year: 2010, vol: 21, page: 699, stat: Journal Article,

CD36 Partners with a Novel TLR Heterodimer TLR4/TLR6 to Promote Atherosclerosis
Rayner, Katey J.; Rodrigues-Fernandes, Luciana; Martin-Fuentes, Paula; Wilkinson, Kim; Stewart, Cameron; van Gils, Janine M.; Stuart, Lynda; Moore, Kathryn J.
2010 NOV ;30(11):E186-E186, Arteriosclerosis, thrombosis, & vascular biology
— id: 117303, year: 2010, vol: 30, page: E186, stat: Journal Article,

Mir-33 Coordinates Genes Regulating Cholesterol Homeostasis
Rayner, Katey J.; Suarez, Yajaira; Davalos, Alberto; Parathath, Saj; Fitzgerald, Michael L.; Tamehiro, Norimasa; Fisher, Edward A.; Moore, Kathryn J.; Fernandez-Hernando, Carlos
2010 NOV ;30(11):E191-E191, Arteriosclerosis, thrombosis, & vascular biology
— id: 117305, year: 2010, vol: 30, page: E191, stat: Journal Article,

MiR-33 contributes to the regulation of cholesterol homeostasis
Rayner, Katey J; Suarez, Yajaira; Davalos, Alberto; Parathath, Saj; Fitzgerald, Michael L; Tamehiro, Norimasa; Fisher, Edward A; Moore, Kathryn J; Fernandez-Hernando, Carlos
2010 Jun 18;328(5985):1570-1573, Science
— id: 138135, year: 2010, vol: 328, page: 1570, stat: Journal Article,

Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
Seimon, Tracie A; Nadolski, Marissa J; Liao, Xianghai; Magallon, Jorge; Nguyen, Matthew; Feric, Nicole T; Koschinsky, Marlys L; Harkewicz, Richard; Witztum, Joseph L; Tsimikas, Sotirios; Golenbock, Douglas; Moore, Kathryn J; Tabas, Ira
2010 Nov 3;12(5):467-482, Cell metabolism
— id: 114148, year: 2010, vol: 12, page: 467, stat: Journal Article,

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Stewart, Cameron R; Stuart, Lynda M; Wilkinson, Kim; van Gils, Janine M; Deng, Jiusheng; Halle, Annett; Rayner, Katey J; Boyer, Laurent; Zhong, Ruiqin; Frazier, William A; Lacy-Hulbert, Adam; Khoury, Joseph El; Golenbock, Douglas T; Moore, Kathryn J
2010 Feb;11(2):155-161, Nature immunology
— id: 106611, year: 2010, vol: 11, page: 155, stat: Journal Article,

THE GUIDANCE CUE NETRIN-1 PROMOTES ATHEROSCLEROSIS
van Gils, J. M.; Stewart, M. C.; Rayner, K. J.; Fernandes, L. R.; McDonald, T. O.; O'Brien, K. D.; Moore, K. J.
2010 JUN 10 ;11(2):14-14, Atherosclerosis. Supplements
— id: 112195, year: 2010, vol: 11, page: 14, stat: Journal Article,

Netrin-1: A Multifunctional Guidance Cue that Promotes Atherosclerosis
van Gils, Janine M.; Stewart, Merran C.; Rayner, Katey J.; Fernandes, Luciana R.; McDonald, Thomas O.; OBrien, Kevin D.; Moore, Kathryn J.
2010 NOV ;30(11):E292-E292, Arteriosclerosis, thrombosis, & vascular biology
— id: 117309, year: 2010, vol: 30, page: E292, stat: Journal Article,

Vascular effects of a low-carbohydrate high-protein diet
Foo, Shi Yin; Heller, Eric R; Wykrzykowska, Joanna; Sullivan, Christopher J; Manning-Tobin, Jennifer J; Moore, Kathryn J; Gerszten, Robert E; Rosenzweig, Anthony
2009 Sep 8;106(36):15418-15423, Proceedings of the National Academy of Sciences of the United States of America
— id: 106612, year: 2009, vol: 106, page: 15418, stat: Journal Article,

Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice
Luong, Mai X; Tam, Joshua; Lin, Qingcong; Hagendoorn, Jeroen; Moore, Kathryn J; Padera, Timothy P; Seed, Brian; Fukumura, Dai; Kucherlapati, Raju; Jain, Rakesh K
2009 May;219(2):430-437, Journal of cellular physiology
— id: 106614, year: 2009, vol: 219, page: 430, stat: Journal Article,

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice
Manning-Tobin, Jennifer J; Moore, Kathryn J; Seimon, Tracie A; Bell, Susan A; Sharuk, Maia; Alvarez-Leite, Jacqueline I; de Winther, Menno P J; Tabas, Ira; Freeman, Mason W
2009 Jan;29(1):19-26, Arteriosclerosis, thrombosis, & vascular biology
— id: 106615, year: 2009, vol: 29, page: 19, stat: Journal Article,

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
Means, Terry K; Mylonakis, Eleftherios; Tampakakis, Emmanouil; Colvin, Richard A; Seung, Edward; Puckett, Lindsay; Tai, Melissa F; Stewart, Cameron R; Pukkila-Worley, Read; Hickman, Suzanne E; Moore, Kathryn J; Calderwood, Stephen B; Hacohen, Nir; Luster, Andrew D; El Khoury, Joseph
2009 Mar 16;206(3):637-653, Journal of experimental medicine
— id: 106613, year: 2009, vol: 206, page: 637, stat: Journal Article,

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
Halle, Annett; Hornung, Veit; Petzold, Gabor C; Stewart, Cameron R; Monks, Brian G; Reinheckel, Thomas; Fitzgerald, Katherine A; Latz, Eicke; Moore, Kathryn J; Golenbock, Douglas T
2008 Aug;9(8):857-865, Nature immunology
— id: 106616, year: 2008, vol: 9, page: 857, stat: Journal Article,

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
Ip, W K Eddie; Takahashi, Kazue; Moore, Kathryn J; Stuart, Lynda M; Ezekowitz, R Alan B
2008 Jan 21;205(1):169-181, Journal of experimental medicine
— id: 106618, year: 2008, vol: 205, page: 169, stat: Journal Article,

Targeting Innate Immunity for CV Benefit
Moore KJ; Freeman MW
2008 ;5(1):15-23, Drug discovery today. Therapeutic strategies
— id: 106619, year: 2008, vol: 5, page: 15, stat: Journal Article,

Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications
Stewart, Cameron R; Haw, Antonio 3rd; Lopez, Roland; McDonald, Thomas O; Callaghan, Judy M; McConville, Malcolm J; Moore, Kathryn J; Howlett, Geoffrey J; O'Brien, Kevin D
2007 Oct;48(10):2162-2171, Journal of lipid research
— id: 106620, year: 2007, vol: 48, page: 2162, stat: Journal Article,

CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex
Stuart, Lynda M; Bell, Susan A; Stewart, Cameron R; Silver, Jessica M; Richard, James; Goss, Julie L; Tseng, Anita A; Zhang, Ailiang; El Khoury, Joseph B; Moore, Kathryn J
2007 Sep 14;282(37):27392-27401, Journal of biological chemistry
— id: 106621, year: 2007, vol: 282, page: 27392, stat: Journal Article,

Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy
Webb, Nancy R; Moore, Kathryn J
2007 Dec;8(12):1249-1263, Current drug targets
— id: 106617, year: 2007, vol: 8, page: 1249, stat: Journal Article,

Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI
Brundert, May; Heeren, Joerg; Bahar-Bayansar, Mukaddes; Ewert, Anne; Moore, Kathryn J; Rinninger, Franz
2006 Nov;47(11):2408-2421, Journal of lipid research
— id: 106624, year: 2006, vol: 47, page: 2408, stat: Journal Article,

Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells
Heller, Eric A; Liu, Emerson; Tager, Andrew M; Yuan, Qian; Lin, Alexander Y; Ahluwalia, Neil; Jones, Krister; Koehn, Stephanie L; Lok, Vincent M; Aikawa, Elena; Moore, Kathryn J; Luster, Andrew D; Gerszten, Robert E
2006 May 16;113(19):2301-2312, Circulation
— id: 106627, year: 2006, vol: 113, page: 2301, stat: Journal Article,

Untangling the role of amyloid in atherosclerosis
Howlett, Geoffrey J; Moore, Kathryn J
2006 Oct;17(5):541-547, Current opinion in lipidology
— id: 106623, year: 2006, vol: 17, page: 541, stat: Journal Article,

Designer macrophages: oxidative metabolism fuels inflammation repair
Lacy-Hulbert, Adam; Moore, Kathryn J
2006 Jul;4(1):7-8, Cell metabolism
— id: 106625, year: 2006, vol: 4, page: 7, stat: Journal Article,

Scavenger receptors in atherosclerosis: beyond lipid uptake
Moore, Kathryn J; Freeman, Mason W
2006 Aug;26(8):1702-1711, Arteriosclerosis, thrombosis, & vascular biology
— id: 106626, year: 2006, vol: 26, page: 1702, stat: Journal Article,

Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages
Seimon, Tracie A; Obstfeld, Amrom; Moore, Kathryn J; Golenbock, Douglas T; Tabas, Ira
2006 Dec 26;103(52):19794-19799, Proceedings of the National Academy of Sciences of the United States of America
— id: 106622, year: 2006, vol: 103, page: 19794, stat: Journal Article,

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment
Heller, Eric A; Liu, Emerson; Tager, Andrew M; Sinha, Sumita; Roberts, Jesse D; Koehn, Stephanie L; Libby, Peter; Aikawa, Elena Rabkin; Chen, Ji Qiu; Huang, Paul; Freeman, Mason W; Moore, Kathryn J; Luster, Andrew D; Gerszten, Robert E
2005 Jul 26;112(4):578-586, Circulation
— id: 106631, year: 2005, vol: 112, page: 578, stat: Journal Article,

Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels
Kim, Woojin Scott; Fitzgerald, Michael L; Kang, Kihwa; Okuhira, Kei-ichiro; Bell, Susan A; Manning, Jennifer J; Koehn, Stephanie L; Lu, Naifang; Moore, Kathryn J; Freeman, Mason W
2005 Feb 4;280(5):3989-3995, Journal of biological chemistry
— id: 106635, year: 2005, vol: 280, page: 3989, stat: Journal Article,

Atherosclerosis and innate immune signaling
Laberge, Marc A; Moore, Kathryn J; Freeman, Mason W
2005 ;37(2):130-140, Annals of medicine (Helsinki)
— id: 106632, year: 2005, vol: 37, page: 130, stat: Journal Article,

Netrin-1 inhibits leukocyte migration in vitro and in vivo
Ly, Ngoc P; Komatsuzaki, Katsumi; Fraser, Iain P; Tseng, Anita A; Prodhan, Parthak; Moore, Kathryn J; Kinane, T Bernard
2005 Oct 11;102(41):14729-14734, Proceedings of the National Academy of Sciences of the United States of America
— id: 106628, year: 2005, vol: 102, page: 14729, stat: Journal Article,

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
Moore, Kathryn J; Kunjathoor, Vidya V; Koehn, Stephanie L; Manning, Jennifer J; Tseng, Anita A; Silver, Jessica M; McKee, Mary; Freeman, Mason W
2005 Aug;115(8):2192-2201, Journal of clinical investigation
— id: 106629, year: 2005, vol: 115, page: 2192, stat: Journal Article,

Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages
Stewart, Cameron R; Tseng, Anita A; Mok, Yee-Foong; Staples, Maree K; Schiesser, Carl H; Lawrence, Lynne J; Varghese, Jose N; Moore, Kathryn J; Howlett, Geoffrey J
2005 Jun 28;44(25):9108-9116, Biochemistry
— id: 106633, year: 2005, vol: 44, page: 9108, stat: Journal Article,

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
Stuart, Lynda M; Deng, Jiusheng; Silver, Jessica M; Takahashi, Kazue; Tseng, Anita A; Hennessy, Elizabeth J; Ezekowitz, R Alan B; Moore, Kathryn J
2005 Aug 1;170(3):477-485, Journal of cell biology
— id: 106630, year: 2005, vol: 170, page: 477, stat: Journal Article,

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
Bjorkbacka, Harry; Kunjathoor, Vidya V; Moore, Kathryn J; Koehn, Stephanie; Ordija, Christine M; Lee, Melinda A; Means, Terry; Halmen, Kristen; Luster, Andrew D; Golenbock, Douglas T; Freeman, Mason W
2004 Apr;10(4):416-421, Nature medicine
— id: 106637, year: 2004, vol: 10, page: 416, stat: Journal Article,

beta-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins
Kunjathoor VV; Tseng AA; Medeiros LA; Khan T; Moore KJ
2004 Nov 16;1(1):23-23, Journal of neuroinflammation
— id: 106636, year: 2004, vol: 1, page: 23, stat: Journal Article,

Fibrillar amyloid protein present in atheroma activates CD36 signal transduction
Medeiros, Lea A; Khan, Tayeba; El Khoury, Joseph B; Pham, Chi L L; Hatters, Danny M; Howlett, Geoffrey J; Lopez, Roland; O'Brien, Kevin D; Moore, Kathryn J
2004 Mar 12;279(11):10643-10648, Journal of biological chemistry
— id: 106638, year: 2004, vol: 279, page: 10643, stat: Journal Article,

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
Ricci, Romeo; Sumara, Grzegorz; Sumara, Izabela; Rozenberg, Izabela; Kurrer, Michael; Akhmedov, Alexander; Hersberger, Martin; Eriksson, Urs; Eberli, Franz R; Becher, Burkhard; Boren, Jan; Chen, Mian; Cybulsky, Myron I; Moore, Kathryn J; Freeman, Mason W; Wagner, Erwin F; Matter, Christian M; Luscher, Thomas F
2004 Nov 26;306(5701):1558-1561, Science
— id: 106634, year: 2004, vol: 306, page: 1558, stat: Journal Article,

CD36 mediates the innate host response to beta-amyloid
El Khoury, Joseph B; Moore, Kathryn J; Means, Terry K; Leung, Josephine; Terada, Kinya; Toft, Michelle; Freeman, Mason W; Luster, Andrew D
2003 Jun 16;197(12):1657-1666, Journal of experimental medicine
— id: 106639, year: 2003, vol: 197, page: 1657, stat: Journal Article,

eLiXiRs for restraining inflammation
Freeman, Mason W; Moore, Kathryn J
2003 Feb;9(2):168-169, Nature medicine
— id: 106640, year: 2003, vol: 9, page: 168, stat: Journal Article,

Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home
Fitzgerald, Michael L; Moore, Kathryn J; Freeman, Mason W
2002 May;80(5):271-281, Journal of molecular medicine (Berlin)
— id: 106643, year: 2002, vol: 80, page: 271, stat: Journal Article,

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
Kunjathoor, Vidya V; Febbraio, Maria; Podrez, Eugene A; Moore, Kathryn J; Andersson, Lorna; Koehn, Stephanie; Rhee, Jeongmi S; Silverstein, Roy; Hoff, Henry F; Freeman, Mason W
2002 Dec 20;277(51):49982-49988, Journal of biological chemistry
— id: 106641, year: 2002, vol: 277, page: 49982, stat: Journal Article,

A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
Moore, Kathryn J; El Khoury, Joseph; Medeiros, Lea A; Terada, Kinya; Geula, Changiz; Luster, Andrew D; Freeman, Mason W
2002 Dec 6;277(49):47373-47379, Journal of biological chemistry
— id: 106642, year: 2002, vol: 277, page: 47373, stat: Journal Article,

ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space
Fitzgerald, M L; Mendez, A J; Moore, K J; Andersson, L P; Panjeton, H A; Freeman, M W
2001 May 4;276(18):15137-15145, Journal of biological chemistry
— id: 106645, year: 2001, vol: 276, page: 15137, stat: Journal Article,

Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?
Moore, K J; Fitzgerald, M L; Freeman, M W
2001 Oct;12(5):519-527, Current opinion in lipidology
— id: 106644, year: 2001, vol: 12, page: 519, stat: Journal Article,

The role of PPAR-gamma in macrophage differentiation and cholesterol uptake
Moore, K J; Rosen, E D; Fitzgerald, M L; Randow, F; Andersson, L P; Altshuler, D; Milstone, D S; Mortensen, R M; Spiegelman, B M; Freeman, M W
2001 Jan;7(1):41-47, Nature medicine
— id: 106646, year: 2001, vol: 7, page: 41, stat: Journal Article,

Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice
Fabunmi, R P; Moore, K J; Libby, P; Freeman, M W
2000 Feb;148(2):375-386, Atherosclerosis
— id: 106649, year: 2000, vol: 148, page: 375, stat: Journal Article,

Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages
Fitzgerald, M L; Moore, K J; Freeman, M W; Reed, G L
2000 Mar 1;164(5):2692-2700, Journal of immunology
— id: 106648, year: 2000, vol: 164, page: 2692, stat: Journal Article,

Divergent response to LPS and bacteria in CD14-deficient murine macrophages
Moore, K J; Andersson, L P; Ingalls, R R; Monks, B G; Li, R; Arnaout, M A; Golenbock, D T; Freeman, M W
2000 Oct 15;165(8):4272-4280, Journal of immunology
— id: 106647, year: 2000, vol: 165, page: 4272, stat: Journal Article,

In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions
Moore, K J; Fabunmi, R P; Andersson, L P; Freeman, M W
1998 Oct;18(10):1647-1654, Arteriosclerosis, thrombosis, & vascular biology
— id: 106650, year: 1998, vol: 18, page: 1647, stat: Journal Article,