Kathryn J. Moore

Biosketch / Results /

Kathryn Moore

Jean and David Blechman Professor of Cardiology, Department of Medicine;Professor, Department of Cell Biology

Contact Info

522 First Avenue
New York, NY 10016


Research Interests

The overall interest of the Moore Laboratory is to understand (1) the role of the innate immune system in sterile inflammatory conditions and host defense, and (2) the role of microRNAs in regulating lipoprotein metabolism and atherosclerosis. The innate immune system senses the presence of invading microorganisms and modified endogenous ligands by recognizing conserved molecular structures that are normally absent in the healthy host. Myeloid cells express classes of pattern recognition receptors, such as the scavenger receptors (SRs) and toll-like receptors (TLRs), that bind conserved a??non-selfa?? patterns to mediate this important function. Although often thought of as a broad, primitive defense mechanism, it is becoming increasingly clear that pattern recognition receptors can cooperate to precisely regulate signaling pathways essential for the proper initiation of innate and acquired immunity. However, the inappropriate activation of these receptors has also been linked to inflammatory syndromes, including atherosclerosis and Alzheimer's disease. MicroRNAs (miRNAs) represent an elegant mechanism of posttranscriptional control of gene expression that serves to fine-tune biological pathways. These tiny noncoding RNAs (20a??22 nucleotide) bind to the 3' untranslated region of mRNAs, thereby repressing gene expression. Recent advances in the understanding of lipid metabolism have revealed that miRNAs, particularly miR-33, play major roles in regulating cholesterol and fatty acid homeostasis. Work from our group identified miR-33, an intronic miRNA located with the sterol response element-binding protein (SREBP)-2 gene, as an important regulator of cellular cholesterol efflux, fatty acid I? oxidation, and high-density lipoprotein metabolism. Using inhibitors of miR-33, we showed in mice and non-human primates that antagonism of this microRNA increases plasma HDL and reduces VLDL triglycerides. These findings have highlighted the important role that miRNAs play in lipoprotein metabolism and opened new avenues for the treatment of dyslipidemias.

LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2
Hussein, Maryem A; Shrestha, Elina; Ouimet, Mireille; Barrett, Tessa J; Leone, Sarah; Moore, Kathryn J; Herault, Yann; Fisher, Edward A; Garabedian, Michael J
2015-08-23; 1932-6203,PLoS one - id: 1732262, year: 2015 Journal Article

Women in Metabolism: Part I
Kahn, Barbara; Simon, MCeleste; Zhang, Bei B; Zierath, Juleen R; Muoio, Deborah M; Moore, Kathryn J; Cannon, Barbara; Haigis, Marcia; Schoonjans, Kristina; Mandrup, Susanne; Clement, Karine; Andrews, Nancy C
2015-06-04; 1932-7420,Cell metabolism - id: 1610162, year: 2015

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis
Karunakaran, Denuja; Thrush, A Brianne; Nguyen, My-Anh; Richards, Laura; Geoffrion, Michele; Singaravelu, Ragunath; Ramphos, Eleni; Shangari, Prakriti; Ouimet, Mireille; Pezacki, John P; Moore, Kathryn J; Perisic, Ljubica; Maegdefessel, Lars; Hedin, Ulf; Harper, Mary-Ellen; Rayner, Katey J
2015-07-26; 1524-4571,Circulation research - id: 1684582, year: 2015 Journal Article

Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation
Mediero, Aranzazu; Ramkhelawon, Bhama; Perez-Aso, Miguel; Moore, Kathryn J; Cronstein, Bruce N
2015-04-27; 1523-4681,Journal of bone & mineral research - id: 1543872, year: 2015 Journal Article

Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis
Mediero, Aranzazu; Ramkhelawon, Bhama; Wilder, Tuere; Purdue, P Edward; Goldring, Steven R; Dewan, M Zahidunnabi; Loomis, Cynthia; Moore, Kathryn J; Cronstein, Bruce N
2015-10-12; 1468-2060,Annals of the rheumatic diseases - id: 1794812, year: 2015 JOURNAL ARTICLE