Daniel Meruelo

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Daniel Meruelo

Professor, Department of Pathology
Director Gene Therapy Center

Contact Info

180 Varick Street
New York, NY 10014


Research Summary

Our group is involved in the development of gene therapy vectors that can target and eradicate tumor cells in vivo, whether they be localized or spread throughout the body. We utilize state of the art approaches to achieve this goal, including in vivo imaging. Also we are engaged in studies of the high affinity laminin receptor, understanding its role in cancer, and its structure. Other efforts in the lab are directed at discovering novel therapeutic agents for viral diseases and neurological diseases such as Alzheimers.

Research Interests

Gene Therapy, Alzheimer's research

The transition of the 37-kDa laminin receptor (RPSA) to higher molecular weight species: SUMOylation or artifact?
Digiacomo, Vincent; Gando, Ivan A; Venticinque, Lisa; Hurtado, Alicia; Meruelo, Daniel
2015-07-13; 1689-1392,Cellular & molecular biology letters - id: 1662552, year: 2015 JOURNAL ARTICLE

Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein
DiGiacomo, Vincent; Meruelo, Daniel
2015-02-03; 1464-7931,Biological reviews of the Cambridge Philosophical Society - id: 1447872, year: 2015 JOURNAL ARTICLE

Screening strategies to identify HSP70 modulators to treat Alzheimer's disease
Repalli, Jayanthi; Meruelo, Daniel
2015-01-26; 1177-8881,Drug design, development & therapy - id: 1440392, year: 2015 REVIEW

TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth
Daniels, Garrett; Li, Yirong; Gellert, Lan Lin; Zhou, Albert; Melamed, Jonathan; Wu, Xinyu; Zhang, Xinming; Zhang, David; Meruelo, Daniel; Logan, Susan K; Basch, Ross; Lee, Peng
2014-07-29; 1351-0088,Endocrine-related cancer - id: 1083962, year: 2014 Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Sindbis Viral Vectors Transiently Deliver Tumor-associated Antigens to Lymph Nodes and Elicit Diversified Antitumor CD8(+) T-cell Immunity
Granot, Tomer; Yamanashi, Yoshihide; Meruelo, Daniel
2014-02-03; 1525-0016,Molecular therapy - id: 781242, year: 2014 Journal Article