Daniel Meruelo

Biosketch / Results /

Daniel Meruelo

Professor, Department of Pathology
Director Gene Therapy Center

Contact Info

Address
180 Varick Street
New York, NY 10014

212/263-3599
Daniel.Meruelo@nyumc.org

Research Summary

Our group is involved in the development of gene therapy vectors that can target and eradicate tumor cells in vivo, whether they be localized or spread throughout the body. We utilize state of the art approaches to achieve this goal, including in vivo imaging. Also we are engaged in studies of the high affinity laminin receptor, understanding its role in cancer, and its structure. Other efforts in the lab are directed at discovering novel therapeutic agents for viral diseases and neurological diseases such as Alzheimers.

Research Interests

Gene Therapy, Alzheimer's research

The transition of the 37-kDa laminin receptor (RPSA) to higher molecular weight species: SUMOylation or artifact?
Digiacomo, Vincent; Gando, Ivan A; Venticinque, Lisa; Hurtado, Alicia; Meruelo, Daniel. The transition of the 37-kDa laminin receptor (RPSA) to higher molecular weight species: SUMOylation or artifact?. Cellular & molecular biology letters. 2015 Dec ;20(4):571-585 (1662552)

Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein
DiGiacomo, Vincent; Meruelo, Daniel. Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein. Biological reviews of the Cambridge Philosophical Society. 2015 Jan 28;91(2):288-310 (1447872)

Screening strategies to identify HSP70 modulators to treat Alzheimer's disease
Repalli, Jayanthi; Meruelo, Daniel. Screening strategies to identify HSP70 modulators to treat Alzheimer's disease. Drug design, development & therapy. 2015 Jan 7;9:321-331 (1440392)

TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth
Daniels, Garrett; Li, Yirong; Gellert, Lan Lin; Zhou, Albert; Melamed, Jonathan; Wu, Xinyu; Zhang, Xinming; Zhang, David; Meruelo, Daniel; Logan, Susan K; Basch, Ross; Lee, Peng. TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth. Endocrine-related cancer. 2014 Jan 16;21(1):127-142 (1083962)

Interaction of Human Laminin Receptor with Sup35, the [PSI (+)] Prion-Forming Protein from S. cerevisiae: A Yeast Model for Studies of LamR Interactions with Amyloidogenic Proteins
Pampeno, Christine; Derkatch, Irina L; Meruelo, Daniel. Interaction of Human Laminin Receptor with Sup35, the [PSI (+)] Prion-Forming Protein from S. cerevisiae: A Yeast Model for Studies of LamR Interactions with Amyloidogenic Proteins. PLoS one. 2014 Jan 8;9(1):e86013-e86013 e86013 (741192)