Biosketch / Results /

Paul M. Mathews, Ph.D.

Assistant Professor;
Department of Psychiatry

Contact Info

Address
140 Old Orangeburg Road
Orangeburg, NY 10962

845-398-5428
845-398-5422
Paul.Mathews@nyumc.org


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Education

— 1992-1994 Fellow, Cell Biology, University of Lausanne, Switzerland, PostDoctoral Training
— 1995-1997 Resident Fellow, Neurobiology, McLean Hospital, Harvard Medical School, Department of Psychiatry, PostDoctoral Training
— Johns Hopkins Univ, Graduate Education
1991 — Johns Hopkins Univ, Medical Education

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age
Duffy, Aine M; Morales-Corraliza, Jose; Bermudez-Hernandez, Keria M; Schaner, Michael J; Magagna-Poveda, Alejandra; Mathews, Paul M; Scharfman, Helen E
2014 Jul;:1-6, Neurobiology of aging
— id: 1141552, year: 2014, vol: , page: 1, stat: Journal Article,

Early Endosomal Abnormalities and Cholinergic Neuron Degeneration in Amyloid-beta Protein Precursor Transgenic Mice
Choi, Jennifer H K; Kaur, Gurjinder; Mazzella, Matthew J; Morales-Corraliza, Jose; Levy, Efrat; Mathews, Paul M
2013 Jan;34(3):691-700, Journal of Alzheimer's disease
— id: 231162, year: 2013, vol: 34, page: 691, stat: Journal Article,

Interactome Analyses of Mature gamma-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2
Jeon, Amy Hye Won; Bohm, Christopher; Chen, Fusheng; Huo, Hairu; Ruan, Xueying; Ren, Carl He; Ho, Keith; Qamar, Seema; Mathews, Paul M; Fraser, Paul E; Mount, Howard T J; St George-Hyslop, Peter; Schmitt-Ulms, Gerold
2013 May;288(21):15352-15366, Journal of biological chemistry
— id: 387052, year: 2013, vol: 288, page: 15352, stat: Journal Article,

Immunization targeting a minor plaque constituent clears beta-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
Morales-Corraliza, Jose; Schmidt, Stephen D; Mazzella, Matthew J; Berger, Jason D; Wilson, Donald A; Wesson, Daniel W; Jucker, Mathias; Levy, Efrat; Nixon, Ralph A; Mathews, Paul M
2013 Jan;34(1):137-145, Neurobiology of aging
— id: 180342, year: 2013, vol: 34, page: 137, stat: Journal Article,

Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of tau Protein Following Onset of Diabetes in NOD Mice
Papon, Marie-Amelie; El Khoury, Noura B; Marcouiller, Francois; Julien, Carl; Morin, Francoise; Bretteville, Alexis; Petry, Franck R; Gaudreau, Simon; Amrani, Abdelaziz; Mathews, Paul M; Hebert, Sebastien S; Planel, Emmanuel
2013 Feb;62(2):609-617, Diabetes
— id: 221422, year: 2013, vol: 62, page: 609, stat: Journal Article,

Chronic anti-murine Abeta immunization preserves odor guided behaviors in an Alzheimer's beta-amyloidosis model
Wesson, Daniel W; Morales-Corraliza, Jose; Mazzella, Matthew J; Wilson, Donald A; Mathews, Paul M
2013 Jan;237:96-102, Behavioural brain research
— id: 182472, year: 2013, vol: 237, page: 96, stat: Journal Article,

Calpastatin modulates APP processing in the brains of beta-amyloid depositing but not wild-type mice
Morales-Corraliza, Jose; Berger, Jason D; Mazzella, Matthew J; Neubert, Thomas A; Ghiso, Jorge; Rao, Mala V; Staufenbiel, Matthias; Nixon, Ralph A; Mathews, Paul M
2012 Jun;33(6):1125.e9-1125.18, Neurobiology of aging
— id: 164336, year: 2012, vol: 33, page: 1125.e9, stat: Journal Article,

Abeta measurement by enzyme-linked immunosorbent assay
Schmidt, Stephen D; Mazzella, Matthew J; Nixon, Ralph A; Mathews, Paul M
2012 ;849:507-527, Methods in molecular biology
— id: 166104, year: 2012, vol: 849, page: 507, stat: Journal Article,

Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including abeta
Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M
2012 ;849:493-506, Methods in molecular biology
— id: 166105, year: 2012, vol: 849, page: 493, stat: Journal Article,

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
Delay, Charlotte; Calon, Frederic; Mathews, Paul; Hebert, Sebastien S
2011 ;6:70-70, Molecular neurodegeneration
— id: 140551, year: 2011, vol: 6, page: 70, stat: Journal Article,

Catabolism of Alzheimer's amyloid-b: Implications for brain clearance and plaque deposition
McIntee F.L.; Giannoni P.; Blais S.; Neubert T.; Mathews P.; Rostagno A.; Ghiso J.
2011 ;8:?-?, Neuro-degenerative diseases
— id: 136531, year: 2011, vol: 8, page: ?, stat: Journal Article,

Synaptic Autoregulation by Metalloproteases and {gamma}-Secretase
Restituito, Sophie; Khatri, Latika; Ninan, Ipe; Mathews, Paul M; Liu, Xin; Weinberg, Richard J; Ziff, Edward B
2011 Aug 24;31(34):12083-12093, Journal of neuroscience
— id: 136951, year: 2011, vol: 31, page: 12083, stat: Journal Article,

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel W; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jul 1;7(7):788-789, Autophagy
— id: 134440, year: 2011, vol: 7, page: 788, stat: Journal Article,

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Yang, Dun-Sheng; Stavrides, Philip; Mohan, Panaiyur S; Kaushik, Susmita; Kumar, Asok; Ohno, Masuo; Schmidt, Stephen D; Wesson, Daniel; Bandyopadhyay, Urmi; Jiang, Ying; Pawlik, Monika; Peterhoff, Corrinne M; Yang, Austin J; Wilson, Donald A; St George-Hyslop, Peter; Westaway, David; Mathews, Paul M; Levy, Efrat; Cuervo, Ana M; Nixon, Ralph A
2011 Jan;134(Pt 1):258-277, Brain
— id: 126481, year: 2011, vol: 134, page: 258, stat: Journal Article,

Dietary fat and cholesterol cause neuronal endosomal abnormalities and basal forebrain cholinergic degeneration in wild-type mice
Choi, JHK; Boyer-Boiteau, A; Morales-Corraliza, J; Ginsberg, SD; Levy, E; Mathews, PM
2010 ;6:?-? #S188, Alzheimer's & dementia
— id: 463422, year: 2010, vol: 6, page: ?, stat: Journal Article,

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
Coomaraswamy, Janaky; Kilger, Ellen; Wolfing, Heidrun; Schafer, Claudia; Kaeser, Stephan A; Wegenast-Braun, Bettina M; Hefendehl, Jasmin K; Wolburg, Hartwig; Mazzella, Matthew; Ghiso, Jorge; Goedert, Michel; Akiyama, Haruhiko; Garcia-Sierra, Francisco; Wolfer, David P; Mathews, Paul M; Jucker, Mathias
2010 Apr 27;107(17):7969-7974, Proceedings of the National Academy of Sciences of the United States of America
— id: 137823, year: 2010, vol: 107, page: 7969, stat: Journal Article,

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
Jiang, Ying; Mullaney, Kerry A; Peterhoff, Corrinne M; Che, Shaoli; Schmidt, Stephen D; Boyer-Boiteau, Anne; Ginsberg, Stephen D; Cataldo, Anne M; Mathews, Paul M; Nixon, Ralph A
2010 Jan 26;107(4):1630-1635, Proceedings of the National Academy of Sciences of the United States of America
— id: 126490, year: 2010, vol: 107, page: 1630, stat: Journal Article,

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice
Bernardo, Alexandra; Harrison, Fiona E; McCord, Meghan; Zhao, Jiali; Bruchey, Aleksandra; Davies, Sean S; Jackson Roberts, L 2nd; Mathews, Paul M; Matsuoka, Yasuji; Ariga, Toshio; Yu, Robert K; Thompson, Rebecca; McDonald, Michael P
2009 Nov;30(11):1777-1791, Neurobiology of aging
— id: 95388, year: 2009, vol: 30, page: 1777, stat: Journal Article,

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model
Choi, Jennifer H K; Berger, Jason D; Mazzella, Matthew J; Morales-Corraliza, Jose; Cataldo, Anne M; Nixon, Ralph A; Ginsberg, Stephen D; Levy, Efrat; Mathews, Paul M
2009 Sep;110(6):1818-1827, Journal of neurochemistry
— id: 126493, year: 2009, vol: 110, page: 1818, stat: Journal Article,

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia
Grathwohl, Stefan A; Kalin, Roland E; Bolmont, Tristan; Prokop, Stefan; Winkelmann, Georg; Kaeser, Stephan A; Odenthal, Jorg; Radde, Rebecca; Eldh, Therese; Gandy, Sam; Aguzzi, Adriano; Staufenbiel, Matthias; Mathews, Paul M; Wolburg, Hartwig; Heppner, Frank L; Jucker, Mathias
2009 Nov;12(11):1361-1363, Nature neuroscience
— id: 139850, year: 2009, vol: 12, page: 1361, stat: Journal Article,

Complexes of amyloid-beta and cystatin C in the human central nervous system
Mi, Weiqian; Jung, Sonia S; Yu, Haung; Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M; Tagliavini, Fabrizio; Levy, Efrat
2009 ;18(2):273-280, Journal of Alzheimer's disease
— id: 126494, year: 2009, vol: 18, page: 273, stat: Journal Article,

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice
Morales-Corraliza, Jose; Mazzella, Matthew J; Berger, Jason D; Diaz, Nicole S; Choi, Jennifer H K; Levy, Efrat; Matsuoka, Yasuji; Planel, Emmanuel; Mathews, Paul M
2009 ;4(9):e7134-e7134, PLoS one
— id: 106444, year: 2009, vol: 4, page: e7134, stat: Journal Article,

The in vivo brain interactome of the amyloid precursor protein
Bai, Yu; Markham, Kelly; Chen, Fusheng; Weerasekera, Rasanjala; Watts, Joel; Horne, Patrick; Wakutani, Yosuke; Bagshaw, Rick; Mathews, Paul M; Fraser, Paul E; Westaway, David; St George-Hyslop, Peter; Schmitt-Ulms, Gerold
2008 Jan;7(1):15-34, Molecular & cellular proteomics
— id: 95390, year: 2008, vol: 7, page: 15, stat: Journal Article,

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects
Cataldo, Anne M; Mathews, Paul M; Boiteau, Anne Boyer; Hassinger, Linda C; Peterhoff, Corrinne M; Jiang, Ying; Mullaney, Kerry; Neve, Rachael L; Gruenberg, Jean; Nixon, Ralph A
2008 Aug;173(2):370-384, American journal of pathology
— id: 95387, year: 2008, vol: 173, page: 370, stat: Journal Article,

Dysregulation of amyloid precursor protein levels, but not Abeta levels in Ts65Dn mouse brain
Choi, JHK; Diaz, NS; Mazzella, MJ; Ginsberg, SD; Levy, E; Nixon, RA; Mathews, PM
2008 ;4:?-? #T208-T209, Alzheimer's & dementia
— id: 463382, year: 2008, vol: 4, page: ?, stat: Journal Article,

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
Trinchese, Fabrizio; Fa', Mauro; Liu, Shumin; Zhang, Hong; Hidalgo, Ariel; Schmidt, Stephen D; Yamaguchi, Hisako; Yoshii, Narihiko; Mathews, Paul M; Nixon, Ralph A; Arancio, Ottavio
2008 Aug;118(8):2796-2807, Journal of clinical investigation
— id: 95386, year: 2008, vol: 118, page: 2796, stat: Journal Article,

Dysregulation of brain APP in the Ts65Dn Down syndrome mouse
Choi, JH; Mazzella, MJ; Berger, JD; Cataldo, AM; Ginsberg, SD; Levy, E; Nixon, RA; Mathews, PM
2007 AUG ;102(3):131-131, Journal of neurochemistry
— id: 74183, year: 2007, vol: 102, page: 131, stat: Journal Article,

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins
Dorval, Veronique; Mazzella, Matthew J; Mathews, Paul M; Hay, Ronald T; Fraser, Paul E
2007 Jun 1;404(2):309-316, Biochemical journal
— id: 95392, year: 2007, vol: 404, page: 309, stat: Journal Article,

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor
Elder, Gregory A; Cho, Julie Y; English, Daniel F; Franciosi, Sonia; Schmeidler, James; Sosa, Miguel A Gama; Gasperi, Rita De; Fisher, Edward A; Mathews, Paul M; Haroutunian, Vahram; Buxbaum, Joseph D
2007 Aug;102(4):1220-1231, Journal of neurochemistry
— id: 73883, year: 2007, vol: 102, page: 1220, stat: Journal Article,

Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626))
Gandy, S; Zhang, Y-W; Ikin, A; Schmidt, SD; Bogush, A; Levy, E; Sheffield, R; Nixon, RA; Liao, F-F; Mathews, PM; Xu, H; Ehrlich, ME
2007 ;103(3):1272-, Journal of neurochemistry
— id: 643112, year: 2007, vol: 103, page: 1272, stat: Journal Article,

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (vol 102, pg 619, 2007)
Gandy, S; Zhang, YW; Ikin, A; Schmidt, SD; Bogush, A; Levy, E; Sheffield, R; Nixon, RA; Liao, FF; Mathews, PM; Xu, HX; Ehrlich, ME
2007 NOV ;103(3):1272-1272, Journal of neurochemistry
— id: 74687, year: 2007, vol: 103, page: 1272, stat: Journal Article,

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
Gandy, Sam; Zhang, Yun-wu; Ikin, Annat; Schmidt, Stephen D; Bogush, Alexey; Levy, Efrat; Sheffield, Roxanne; Nixon, Ralph A; Liao, Francesca-Fang; Mathews, Paul M; Xu, Huaxi; Ehrlich, Michelle E
2007 Aug;102(3):619-626, Journal of neurochemistry
— id: 95391, year: 2007, vol: 102, page: 619, stat: Journal Article,

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models
Mi, Weiqian; Pawlik, Monika; Sastre, Magdalena; Jung, Sonia S; Radvinsky, David S; Klein, Andrew M; Sommer, John; Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M; Levy, Efrat
2007 Dec;39(12):1440-1442, Nature genetics
— id: 95389, year: 2007, vol: 39, page: 1440, stat: Journal Article,

Endosome function and pathology in Alzheimer's disease
Cataldo, AM; Mathews, PM; Peterhoff, CM; Boyer-Boiteau, A; Jiang, Y; Nixon, RA
2006 MAR ;96(1):71-71, Journal of neurochemistry
— id: 62904, year: 2006, vol: 96, page: 71, stat: Journal Article,

Dysregulation of brain APP in the Ts65Dn Down syndrome mouse
Choi, JHK; Diaz, NS; Mazzella, MJ; Peterson, JN; Cataldo, AM; Ginsberg, SD; Levy, E; Nixon, RA; Mathews, PM
2006 ;2:?-? #S236, Alzheimer's & dementia
— id: 463402, year: 2006, vol: 2, page: ?, stat: Journal Article,

APP expression modulated AD-related endosomal trafficking abnormalities in Down syndrome fibroblasts
Jiang, Y; Mullaney, KA; Che, S; Schmidt, SD; Mathews, PM; Cataldo, AM; Ginsberg, SD; Nixon, RA
2006 ;2:?-? #S250, Alzheimer's & dementia
— id: 463392, year: 2006, vol: 2, page: ?, stat: Journal Article,

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
Meyer-Luehmann, Melanie; Coomaraswamy, Janaky; Bolmont, Tristan; Kaeser, Stephan; Schaefer, Claudia; Kilger, Ellen; Neuenschwander, Anton; Abramowski, Dorothee; Frey, Peter; Jaton, Anneliese L; Vigouret, Jean-Marie; Paganetti, Paolo; Walsh, Dominic M; Mathews, Paul M; Ghiso, Jorge; Staufenbiel, Matthias; Walker, Lary C; Jucker, Mathias
2006 Sep 22;313(5794):1781-1784, Science
— id: 81091, year: 2006, vol: 313, page: 1781, stat: Journal Article,

Endosome dysfunction in Alzheimer's disease: Genetic links and implications for synapse failure and neurodegeneration
Nixon, RA; Cataldo, A; Mathews, P; Jiang, Y; Ginsberg, SD; Peterhoff, C
2006 DEC ;31(2):S28-S28, Neuropsychopharmacology
— id: 70911, year: 2006, vol: 31, page: S28, stat: Journal Article,

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Radde, Rebecca; Bolmont, Tristan; Kaeser, Stephan A; Coomaraswamy, Janaky; Lindau, Dennis; Stoltze, Lars; Calhoun, Michael E; Jaggi, Fabienne; Wolburg, Hartwig; Gengler, Simon; Haass, Christian; Ghetti, Bernardino; Czech, Christian; Holscher, Christian; Mathews, Paul M; Jucker, Mathias
2006 Sep;7(9):940-946, EMBO reports
— id: 95394, year: 2006, vol: 7, page: 940, stat: Journal Article,

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP
Sano, Yoshitake; Nakaya, Tadashi; Pedrini, Steve; Takeda, Shizu; Iijima-Ando, Kanae; Iijima, Koichi; Mathews, Paul M; Itohara, Shigeyoshi; Gandy, Sam; Suzuki, Toshiharu
2006 ;1:e51-e51, PLoS one
— id: 95393, year: 2006, vol: 1, page: e51, stat: Journal Article,

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment
Tate, Barbara A; Mathews, Paul M
2006 May 25;2006(10):re2-re2, Science of aging knowledge environment
— id: 95395, year: 2006, vol: 2006, page: re2, stat: Journal Article,

Deficiency in neuronal TGF-beta signaling promotes neurodegeneratbn and Alzheimer's pathology
Tesseur, I; Zou, K; Esposito, L; Bard, F; Berber, E; Van Can, J; Lin, AH; Crews, L; Tremblay, P; Mathews, P; Mucke, L; Masliah, E; Wyss-Coray, T
2006 NOV ;116(11):3060-3069, Journal of clinical investigation
— id: 69257, year: 2006, vol: 116, page: 3060, stat: Journal Article,

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
Mastrangelo, Peter; Mathews, Paul M; Chishti, M Azhar; Schmidt, Stephen D; Gu, Yongjun; Yang, Jing; Mazzella, Matthew J; Coomaraswamy, Janaky; Horne, Patrick; Strome, Bob; Pelly, Heather; Levesque, Georges; Ebeling, Chris; Jiang, Ying; Nixon, Ralph A; Rozmahel, Richard; Fraser, Paul E; St George-Hyslop, Peter; Carlson, George A; Westaway, David
2005 Jun 21;102(25):8972-8977, Proceedings of the National Academy of Sciences of the United States of America
— id: 95396, year: 2005, vol: 102, page: 8972, stat: Journal Article,

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W Haung; Cuervo, Ana Maria; Kumar, Asok; Peterhoff, Corrinne M; Schmidt, Stephen D; Lee, Ju-Hyun; Mohan, Panaiyur S; Mercken, Marc; Farmery, Mark R; Tjernberg, Lars O; Jiang, Ying; Duff, Karen; Uchiyama, Yasuo; Naslund, Jan; Mathews, Paul M; Cataldo, Anne M; Nixon, Ralph A
2005 Oct 10;171(1):87-98, Journal of cell biology
— id: 60255, year: 2005, vol: 171, page: 87, stat: Journal Article,

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
Cataldo, Anne M; Peterhoff, Corrinne M; Schmidt, Stephen D; Terio, Nicole B; Duff, Karen; Beard, Margaret; Mathews, Paul M; Nixon, Ralph A
2004 Aug;63(8):821-830, Journal of neuropathology & experimental neurology
— id: 95397, year: 2004, vol: 63, page: 821, stat: Journal Article,

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
Hasegawa, Hiroshi; Sanjo, Nobuo; Chen, Fusheng; Gu, Yong-Jun; Shier, Cortney; Petit, Agnes; Kawarai, Toshitaka; Katayama, Taiichi; Schmidt, Stephen D; Mathews, Paul M; Schmitt-Ulms, Gerold; Fraser, Paul E; St George-Hyslop, Peter
2004 Nov 5;279(45):46455-46463, Journal of biological chemistry
— id: 95398, year: 2004, vol: 279, page: 46455, stat: Journal Article,

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
Herzig, Martin C; Winkler, David T; Burgermeister, Patrick; Pfeifer, Michelle; Kohler, Esther; Schmidt, Stephen D; Danner, Simone; Abramowski, Dorothee; Sturchler-Pierrat, Christine; Burki, Kurt; van Duinen, Sjoerd G; Maat-Schieman, Marion L C; Staufenbiel, Matthias; Mathews, Paul M; Jucker, Mathias
2004 Sep;7(9):954-960, Nature neuroscience
— id: 95399, year: 2004, vol: 7, page: 954, stat: Journal Article,

Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised
Lacombe P; Mathews PM; Schmidt SD; Breidert T; Heneka MT; Landreth GE; Feinstein DL; Galea E
2004 Jul 2;1(1):11-11, Journal of neuroinflammation
— id: 61232, year: 2004, vol: 1, page: 11, stat: Journal Article,

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
Laudon, Hanna; Mathews, Paul M; Karlstrom, Helena; Bergman, Anna; Farmery, Mark R; Nixon, Ralph A; Winblad, Bengt; Gandy, Samuel E; Lendahl, Urban; Lundkvist, Johan; Naslund, Jan
2004 Apr;89(1):44-53, Journal of neurochemistry
— id: 42252, year: 2004, vol: 89, page: 44, stat: Journal Article,

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide
Pawlik, Monika; Sastre, Magdalena; Calero, Miguel; Mathews, Paul M; Schmidt, Stephen D; Nixon, Ralph A; Levy, Efrat
2004 ;22(1-2):13-18, Journal of molecular neuroscience
— id: 42253, year: 2004, vol: 22, page: 13, stat: Journal Article,

Cerebral hemorrhage and amytoid-? [3]
Atwood, CS; Perry, G; Smith, MA; Pfeifer, M; Boncristiano, S; Bondolfi, L; Stalder, A; Deller, T; Staufenbiel, M; Mathews, PM; Jucker, M
2003 ;299(5609):1014-, Science
— id: 651782, year: 2003, vol: 299, page: 1014, stat: Journal Article,

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo
Burns, Mark; Gaynor, Kate; Olm, Vicki; Mercken, Marc; LaFrancois, John; Wang, Lili; Mathews, Paul M; Noble, Wendy; Matsuoka, Yasuji; Duff, Karen
2003 Jul 2;23(13):5645-5649, Journal of neuroscience
— id: 36834, year: 2003, vol: 23, page: 5645, stat: Journal Article,

Extracellular amyloid formation and associated pathology in neural grafts
Meyer-Luehmann, Melanie; Stalder, Martina; Herzig, Martin C; Kaeser, Stephan A; Kohler, Esther; Pfeifer, Michelle; Boncristiano, Sonia; Mathews, Paul M; Mercken, Marc; Abramowski, Dorothee; Staufenbiel, Matthias; Jucker, Mathias
2003 Apr;6(4):370-377, Nature neuroscience
— id: 34106, year: 2003, vol: 6, page: 370, stat: Journal Article,

In vivo reduction of amyloid-beta by a mutant copper transporter
Phinney, Amie L; Drisaldi, Bettina; Schmidt, Stephen D; Lugowski, Stan; Coronado, Veronica; Liang, Yan; Horne, Patrick; Yang, Jing; Sekoulidis, Joannis; Coomaraswamy, Janaky; Chishti, M Azhar; Cox, Diane W; Mathews, Paul M; Nixon, Ralph A; Carlson, George A; St George-Hyslop, Peter; Westaway, David
2003 Nov;100(24):14193-14198, Proceedings of the National Academy of Sciences of the United States of America
— id: 159199, year: 2003, vol: 100, page: 14193, stat: Journal Article,

Rab5 overexpression in a cell model of AD-related endocytic abnormalities influences processing of beta APP
Grbovic, OM; Schmidt, SD; Mathews, PM; Nixon, RA; Cataldo, AM
2002 Jul-Aug;23(1):50-, Neurobiology of aging
— id: 32405, year: 2002, vol: 23, page: 50, stat: Journal Article,

Quantitation of beta-cleaved carboxy-terminal fragments of APP with a novel ELISA
Jiang, Y; Schmidt, SD; Mercken, M; Mathews, PM; Nixon, RA
2002 Jul-Aug;23(1):62-, Neurobiology of aging
— id: 32406, year: 2002, vol: 23, page: 62, stat: Journal Article,

Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein. INHIBITION OF CALPAINS ENHANCES ENDOSOMAL GENERATION OF beta -CLEAVED C-TERMINAL APP FRAGMENTS
Mathews, Paul M; Jiang, Ying; Schmidt, Stephen D; Grbovic, Olivera M; Mercken, Marc; Nixon, Ralph A
2002 Sep 27;277(39):36415-36424, Journal of biological chemistry
— id: 32534, year: 2002, vol: 277, page: 36415, stat: Journal Article,

Altered APP trafficking and a role for the early endosome in increased beta CTF generation following calpain inhibition
Mathews, PM; Nixon, RA; Jiang, Y; Schmidt, SD; Grbovic, OM; Mercken, M; Cataldo, AM
2002 Jul-Aug;23(1):671-, Neurobiology of aging
— id: 32414, year: 2002, vol: 23, page: 671, stat: Journal Article,

AUTOPHAGY IN ALZHEIMER'S DISEASE: AUTOPHAGY - DEPENDENT GENERATION OF THE AMYLOID beta ( Abeta ) PEPTIDE
Nixon, R. A.; Yu, W. H.; Cataldo, A. M.; Mathews, P. M.; Wegiel, J.; Schmidt, S. D.; Ginsberg, S. D.; Peterhoff, C. M.; Terio, N.; Mohan, P.; Hassinger, L.; Kumar, A.; Lamb, B.
2002 ;2002:?-? #624.11, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 458992, year: 2002, vol: 2002, page: ?, stat: Journal Article,

Autophagic cell death: Relevance to Alzheimer disease neurodegeneration
Nixon, RA; Mathews, PM; Ginsberg, SD; Duff, K; Mohan, P; Cataldo, AM; Wegiel, J; Yu, WH; Schmidt, SD; Jacobsen, SP; Peterhoff, CM; Terio, N; Keller, JN; Hassinger, L
2002 Jul-Aug;23:S415-S416, Neurobiology of aging
— id: 32429, year: 2002, vol: 23, page: S415, stat: Journal Article,

Cerebral hemorrhage after passive anti-Abeta immunotherapy
Pfeifer, M; Boncristiano, S; Bondolfi, L; Stalder, A; Deller, T; Staufenbiel, M; Mathews, P M; Jucker, M
2002 Nov 15;298(5597):1379-1379, Science
— id: 32570, year: 2002, vol: 298, page: 1379, stat: Journal Article,

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
Rozmahel, Richard; Mount, Howard T J; Chen, Fusheng; Nguyen, Van; Huang, Jean; Erdebil, Serap; Liauw, Jennifer; Yu, Gang; Hasegawa, Hiroshe; Gu, YongJun; Song, You-Qiang; Schmidt, Stephen D; Nixon, Ralph A; Mathews, Paul M; Bergeron, Catherine; Fraser, Paul; Westaway, David; St George-Hyslop, Peter
2002 Oct 29;99(22):14452-14457, Proceedings of the National Academy of Sciences of the United States of America
— id: 32537, year: 2002, vol: 99, page: 14452, stat: Journal Article,

Murine A beta co-deposition in transgenic mice: Analyses with species-specific antibodies and comparison of human and murine A beta 42 : A beta 40 ratios
Schmidt, S; Jiang, Y; Duff, KEK; Nixon, RA; Mathews, PM; Herzig, MC; Jucker, M; Chishti, MA; Westaway, D; Mercken, M; Staufenbiel, M
2002 Jul-Aug;23(1):920-, Neurobiology of aging
— id: 32422, year: 2002, vol: 23, page: 920, stat: Journal Article,

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
Yang, Dun-Sheng; Tandon, Anurag; Chen, Fusheng; Yu, Gang; Yu, Haung; Arawaka, Shigeki; Hasegawa, Hiroshi; Duthie, Monika; Schmidt, Stephen D; Ramabhadran, Triprayer V; Nixon, Ralph A; Mathews, Paul M; Gandy, Samuel E; Mount, Howard T J; St George-Hyslop, Peter; Fraser, Paul E
2002 Aug 2;277(31):28135-28142, Journal of biological chemistry
— id: 62376, year: 2002, vol: 277, page: 28135, stat: Journal Article,

Autophagy-dependent generation of the amyloid-beta (A beta) peptide
Yu, WH; Schmidt, SD; Jiang, Y; Mathews, PM; Nixon, RA; Hassinger, L; Cataldo, A
2002 Jul-Aug;23(1):48-, Neurobiology of aging
— id: 32404, year: 2002, vol: 23, page: 48, stat: Journal Article,

Accelerated A-beta generation in a cell model of Alzheimer's disease-related endosomal-lysomal system upregulation
Mathews PM; Guerra CB; Jiang Y; Kao BH; Dinakar R; Mehta P; Cataldo AM; Nixon RA
Alzheimer's disease: advances in etiology, pathogenesis and therapeutics Chichester: Wiley, 2001,
— id: 2653, year: 2001, vol: , page: 461, stat: Chapter,

The neuronal endosomal-lysosomal system in Alzheimer's disease
Nixon RA; Mathews PM; Cataldo AM
2001 Feb;3(1):97-107, Journal of Alzheimer's disease
— id: 32538, year: 2001, vol: 3, page: 97, stat: Journal Article,

In vivo perturbation of lysosomal function promotes neurodegeneration in the PS1m146V/APPPK67ON,M671L mouse model of Alzheimer's disease pathology
Nixon RA; Mathews PM; Cataldo AM; Mohan PS; Schmidt SD; Duff K; Berg M; Marks N; Peterhoff C; Sershen H
Alzheimer's disease: advances in etiology, pathogenesis and therapeutics Chichester: Wiley, 2001,
— id: 2654, year: 2001, vol: , page: , stat: Chapter,

Experimental aging of the lysosomal system promotes neurodegeneration in the PS/APP mouse model of Alzheimer's disease pathology
Nixon, R. A.; Mathews, P. M.; Cataldo, A. M.; Mohan, P. S.; Marks, N.; Duff, K.; Berg, M.; Schmidt, S. D.; Jacobsen, S. P.; Jiang, Y.; Sershen, H.
2001 ;27(1):925-925, Abstracts (Society for Neuroscience)
— id: 115690, year: 2001, vol: 27, page: 925, stat: Journal Article,

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus C; Pearson J; McLaurin J; Mathews PM; Jiang Y; Schmidt SD; Chishti MA; Horne P; Heslin D; French J; Mount HT; Nixon RA; Mercken M; Bergeron C; Fraser PE; St George-Hyslop P; Westaway D
2000 Dec 21-28;408(6815):979-982, Nature
— id: 24772, year: 2000, vol: 408, page: 979, stat: Journal Article,

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease
Mathews PM; Cataldo AM; Kao BH; Rudnicki AG; Qin X; Yang JL; Jiang Y; Picciano M; Hulette C; Lippa CF; Bird TD; Nochlin D; Walter J; Haass C; Levesque L; Fraser PE; Andreadis A; Nixon RA
2000 Oct;6(10):878-891, Molecular medicine
— id: 25504, year: 2000, vol: 6, page: 878, stat: Journal Article,

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review
Nixon RA; Cataldo AM; Mathews PM
2000 Oct;25(9-10):1161-1172, Neurochemical research
— id: 24724, year: 2000, vol: 25, page: 1161, stat: Journal Article,

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1
Levesque L; Annaert W; Craessaerts K; Mathews PM; Seeger M; Nixon RA; Van Leuven F; Gandy S; Westaway D; St George-Hyslop P; De Strooper B; Fraser PE
1999 Aug;5(8):542-554, Molecular medicine
— id: 24709, year: 1999, vol: 5, page: 542, stat: Journal Article,

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
Capell A; Saffrich R; Olivo JC; Meyn L; Walter J; Grunberg J; Mathews P; Nixon R; Dotti C; Haass C
1997 Dec;69(6):2432-2440, Journal of neurochemistry
— id: 24765, year: 1997, vol: 69, page: 2432, stat: Journal Article,