Rodolfo Llinas

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Rodolfo Llinas

Thomas and Suzanne Murphy Professor of Neuroscience, Department of Neuroscience Institute;University Professor, Department of Neuroscience Institute
Neuroscience and Physiology

Contact Info

Address
550 First Avenue
New York, NY 10016

Rodolfo.Llinas@nyumc.org


Education

1959 — Universidad Javeriana, Medical Education
1965 — Australian National University, Graduate Education

Research Summary

Our research pertains mostly to neuroscience from the molecular to the cognitive level. We focus on the intrinsic electrophysiological properties of mammalian neurons in vitro, where we correlate ionic conductances with the different molecular structures (channels) responsible for them. In particular, we study the ionic channels that generate some of the sodium and calcium currents responsible for the electrophysiological properties of neurons and their distribution in different cell types (Purkinje-cell and inferior-olivary neurons as well as thalamic and cortical neurons). We also investigate the role of calcium conductance in synaptic transmission in the squid giant synapse, where we demonstrated for the first time the concept of calcium microdomains. At the neuronal-circuit level, we examine cerebellar control of movement and thalamocortical connectivity, as observed in brain slices and isolated wholebrain preparation, using single- and multiple-recording microprobes and ionic-concentration-dependent imaging techniques. We place these studies at the light and ultrastructural levels and analyze them using computer-based mathematical models. At the cognitive level, we focus on thalamocortical interaction and functional mapping in the human brain, using noninvasive magnetoencephalography.

Research Interests

Intrinsic Properties of Neurons

Research Documents


RNS60, a charge-stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production
Choi, Soonwook; Yu, Eunah; Kim, Duk-Soo; Sugimori, Mutsuyuki; Llinas, Rodolfo R
2015-03-08; 2051-817x,Physiological reports - id: 1480822, year: 2015 Journal Article

A bio-inspired multisensory stochastic integration algorithm
Porras, Alex; Llinas, Rodolfo R
2015-02-12; 1872-8286,Neurocomputing - id: 1459612, year: 2015

Enhanced synaptic transmission at the squid giant synapse by artificial seawater based on physically modified saline
Choi, Soonwook; Yu, Eunah; Rabello, Guilherme; Merlo, Suelen; Zemmar, Ajmal; Walton, Kerry D; Moreno, Herman; Moreira, Jorge E; Sugimori, Mutsuyuki; Llinas, Rodolfo R
2014-03-03; 1663-3563,Frontiers in synaptic neuroscience - id: 820782, year: 2014 Journal Article

Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective
Llinas, Rodolfo R
2014-11-23; 1662-5102,Frontiers in cellular neuroscience - id: 1355902, year: 2014 REVIEW

Frequency-pattern functional tomography of magnetoencephalography data allows new approach to the study of human brain organization
Llinas, Rodolfo R; Ustinin, Mikhail N
2014-05-12; 1662-5110,Frontiers in neural circuits - id: 970312, year: 2014 Journal Article