Rodolfo Llinas

Biosketch / Results /

Rodolfo Llinas

Thomas and Suzanne Murphy Professor of Neuroscience, Department of Neuroscience and Physiology;University Professor, Department of Neuroscience and Physiology
Neuroscience Institute

Contact Info

550 First Avenue
New York, NY 10016


1959 — Universidad Javeriana, Medical Education

Research Summary

Our research pertains mostly to neuroscience from the molecular to the cognitive level. We focus on the intrinsic electrophysiological properties of mammalian neurons in vitro, where we correlate ionic conductances with the different molecular structures (channels) responsible for them. In particular, we study the ionic channels that generate some of the sodium and calcium currents responsible for the electrophysiological properties of neurons and their distribution in different cell types (Purkinje-cell and inferior-olivary neurons as well as thalamic and cortical neurons). We also investigate the role of calcium conductance in synaptic transmission in the squid giant synapse, where we demonstrated for the first time the concept of calcium microdomains. At the neuronal-circuit level, we examine cerebellar control of movement and thalamocortical connectivity, as observed in brain slices and isolated wholebrain preparation, using single- and multiple-recording microprobes and ionic-concentration-dependent imaging techniques. We place these studies at the light and ultrastructural levels and analyze them using computer-based mathematical models. At the cognitive level, we focus on thalamocortical interaction and functional mapping in the human brain, using noninvasive magnetoencephalography.

Research Interests

Intrinsic Properties of Neurons

Research Documents

RNS60, a charge-stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production
Choi, Soonwook; Yu, Eunah; Kim, Duk-Soo; Sugimori, Mutsuyuki; Llinas, Rodolfo R
2015-03-08; 2051-817x,Physiological reports - id: 1480822, year: 2015 Journal Article

Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness
Choi, Soonwook; Yu, Eunah; Lee, Seongwon; Llinas, Rodolfo R
2015-06-15; 1091-6490,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 1626262, year: 2015 JOURNAL ARTICLE

Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus
De Ridder, Dirk; Vanneste, Sven; Langguth, Berthold; Llinas, Rodolfo
2015-06-28; 1664-2295,Frontiers in neurology - id: 1640512, year: 2015 Journal Article; Review

Editorial on the Honorary Cerebellum Issue for the Retirement of Enrico Mugnaini
De Zeeuw, Chris I; Jaarsma, Dick; Voogd, Jan; Llinas, Rodolfo; Martina, Marco
2015-10-25; 1473-4230,Cerebellum - id: 1809802, year: 2015 Journal Article

Reconstruction of human brain spontaneous activity based on frequency-pattern analysis of magnetoencephalography data
Llinas, Rodolfo R; Ustinin, Mikhail N; Rykunov, Stanislav D; Boyko, Anna I; Sychev, Vyacheslav V; Walton, Kerry D; Rabello, Guilherme M; Garcia, John
2015-11-08; 1662-4548,Frontiers in neuroscience - id: 1825512, year: 2015 Journal Article