Rodolfo Llinas

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Rodolfo Llinas

Thomas and Suzanne Murphy Professor of Neuroscience, Department of Neuroscience and Physiology
University Professor, Department of Neuroscience and Physiology


Contact Info

Address
550 First Avenue
New York, NY 10016

Rodolfo.Llinas@nyumc.org


Education

1959 — Universidad Javeriana, Medical Education

Research Summary

Our research pertains mostly to neuroscience from the molecular to the cognitive level. We focus on the intrinsic electrophysiological properties of mammalian neurons in vitro, where we correlate ionic conductances with the different molecular structures (channels) responsible for them. In particular, we study the ionic channels that generate some of the sodium and calcium currents responsible for the electrophysiological properties of neurons and their distribution in different cell types (Purkinje-cell and inferior-olivary neurons as well as thalamic and cortical neurons). We also investigate the role of calcium conductance in synaptic transmission in the squid giant synapse, where we demonstrated for the first time the concept of calcium microdomains. At the neuronal-circuit level, we examine cerebellar control of movement and thalamocortical connectivity, as observed in brain slices and isolated wholebrain preparation, using single- and multiple-recording microprobes and ionic-concentration-dependent imaging techniques. We place these studies at the light and ultrastructural levels and analyze them using computer-based mathematical models. At the cognitive level, we focus on thalamocortical interaction and functional mapping in the human brain, using noninvasive magnetoencephalography.

Research Interests

Intrinsic Properties of Neurons

Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain
Choi, Soonwook; Yu, Eunah; Hwang, Eunjin; Llinas, Rodolfo R. Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2016 Feb 8;113(8):2270-2275 (1964612)

Neuromuscular transmission and muscle fatigue changes by nanostructured oxygen
Ivannikov, Maxim V; Sugimori, Mutsuyuki; Llinas, Rodolfo R. Neuromuscular transmission and muscle fatigue changes by nanostructured oxygen. Muscle & nerve. 2016 Jul 16;:?-? (2180312)

Tau Pathology Mediated Presynaptic Dysfunction
Moreno, H; Morfini, G; Buitrago, L; Ujlaki, G; Choi, S; Yu, E; Moreira, J E; Avila, J; Brady, S T; Pant, H; Sugimori, M; Llinas, R R. Tau Pathology Mediated Presynaptic Dysfunction. Neuroscience. 2016 Mar 21;325:30-38 (2052192)

RNS60, a charge-stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production
Choi, Soonwook; Yu, Eunah; Kim, Duk-Soo; Sugimori, Mutsuyuki; Llinas, Rodolfo R. RNS60, a charge-stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production. Physiological reports. 2015 Mar ;3(3):?-? (1480822)

Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness
Choi, Soonwook; Yu, Eunah; Lee, Seongwon; Llinas, Rodolfo R. Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Jun 8;112(25):7839-7844 e001683 (1626262)