Dan Rudolf Littman

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Dan Rudolf Littman, M.D., Ph.D.

Helen L. and Martin S. Kimmel Professor of Molecular Immunology; Professor;
Departments of Pathology (Skirball), Microbiology (Microbiology ) and Molecular Pathogenesis

Contact Info

Address
540 First Avenue
Floor 2 Room 2 Lab-17
Skirball Institute
New York, NY 10016

212-263-7579
212-263-5711
Dan.Littman@med.nyu.edu


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Education

1980 — Washington University, St. Louis, Missouri, Graduate Education

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Research Summary

Our laboratory investigates 1) the molecular events underlying T-lymphocyte differentiation and activation and 2) how the human immunodeficiency virus (HIV) enters target cells and causes systemic depletion of helper T cells. In both areas, we study the functions of T-cell surface molecules and their interactions with intracellular signal transducing components.

During development, CD4 and CD8 glycoproteins are co-expressed on immature thymocytes (double-positive cells), which are then selected according to their ability to interact productively with host major histocompatibility complex (MHC) molecules expressed on thymic epithelium. Cells with T-cell receptors specific for MHC class I shut off CD4 and commit to becoming cytotoxic cells, while cells with T-cell receptors for MHC class II shut off CD8 and become helper cells. We use gene targeting and transgenic technology in mice to study how the double-positive cells commit to either of the two major T-lymphocyte lineages.

In our studies with immunodeficiency viruses, we seek to understand how the interaction of viral envelope glycoproteins with CD4 and various chemokine receptors on the target cells results in membrane fusion and viral entry. We are also developing mouse model systems to determine how HIV infection causes loss of CD4+ helper T cells. In related studies, the functions of chemokine receptors in development and in inflammatory responses are being investigated.

Research Interests

T-lymphocyte Development and Retroviral Pathogenesis

Research Keywords

CD4, gene silencing, human immunodeficiency virus (HIV), signal transduction, T cells, chemokine receptors

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity
Longman, Randy S; Yang, Yi; Diehl, Gretchen E; Kim, Sangwon V; Littman, Dan R
2014 Jun;:193-201 E3, Cold Spring Harbor symposia on quantitative biology
— id: 1065422, year: 2014, vol: , page: 193, stat: Journal Article,

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
van de Pavert, Serge A; Ferreira, Manuela; Domingues, Rita G; Ribeiro, Helder; Molenaar, Rosalie; Moreira-Santos, Lara; Almeida, Francisca F; Ibiza, Sales; Barbosa, Ines; Goverse, Gera; Labao-Almeida, Carlos; Godinho-Silva, Cristina; Konijn, Tanja; Schooneman, Dennis; O'Toole, Tom; Mizee, Mark R; Habani, Yasmin; Haak, Esther; Santori, Fabio R; Littman, Dan R; Schulte-Merker, Stefan; Dzierzak, Elaine; Simas, J Pedro; Mebius, Reina E; Veiga-Fernandes, Henrique
2014 Apr;508(7494):123-127, Nature
— id: 867172, year: 2014, vol: 508, page: 123, stat: Journal Article,

Focused specificity of intestinal T17 cells towards commensal bacterial antigens
Yang, Yi; Torchinsky, Miriam B; Gobert, Michael; Xiong, Huizhong; Xu, Mo; Linehan, Jonathan L; Alonzo, Francis; Ng, Charles; Chen, Alessandra; Lin, Xiyao; Sczesnak, Andrew; Liao, Jia-Jun; Torres, Victor J; Jenkins, Marc K; Lafaille, Juan J; Littman, Dan R
2014 Apr;:152-156, Nature
— id: 963022, year: 2014, vol: , page: 152, stat: Journal Article,

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells
Diehl, Gretchen E; Longman, Randy S; Zhang, Jing-Xin; Breart, Beatrice; Galan, Carolina; Cuesta, Adolfo; Schwab, Susan R; Littman, Dan R
2013 Feb;494(7435):116-120, Nature
— id: 218002, year: 2013, vol: 494, page: 116, stat: Journal Article,

Identification of Potent and Selective Diphenylpropanamide RORgamma Inhibitors
Huh, Jun R; Englund, Erika E; Wang, Hang; Huang, Ruili; Huang, Pengxiang; Rastinejad, Fraydoon; Inglese, James; Austin, Christopher P; Johnson, Ronald L; Huang, Wenwei; Littman, Dan R
2013 Jan;4(1):79-84, ACS medicinal chemistry letters
— id: 531542, year: 2013, vol: 4, page: 79, stat: Journal Article,

GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa
Kim, Sangwon V; Xiang, Wenkai V; Kwak, Changsoo; Yang, Yi; Lin, Xiyao W; Ota, Mitsuhiko; Sarpel, Umut; Rifkin, Daniel B; Xu, Ruliang; Littman, Dan R
2013 May;:1456-1459, Science
— id: 357322, year: 2013, vol: , page: 1456, stat: Journal Article,

Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis
Kruglov, Andrey A; Grivennikov, Sergei I; Kuprash, Dmitry V; Winsauer, Caroline; Prepens, Sandra; Seleznik, Gitta Maria; Eberl, Gerard; Littman, Dan R; Heikenwalder, Mathias; Tumanov, Alexei V; Nedospasov, Sergei A
2013 Dec;342(6163):1243-1246, Science
— id: 700602, year: 2013, vol: 342, page: 1243, stat: Journal Article,

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Parkhurst, Christopher N; Yang, Guang; Ninan, Ipe; Savas, Jeffrey N; Yates, John R 3rd; Lafaille, Juan J; Hempstead, Barbara L; Littman, Dan R; Gan, Wen-Biao
2013 Dec;155(7):1596-1609, Cell
— id: 746582, year: 2013, vol: 155, page: 1596, stat: Journal Article,

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Scher, Jose U; Sczesnak, Andrew; Longman, Randy S; Segata, Nicola; Ubeda, Carles; Bielski, Craig; Rostron, Tim; Cerundolo, Vincenzo; Pamer, Eric G; Abramson, Steven B; Huttenhower, Curtis; Littman, Dan R
2013 ;2(0):476-483, eLife
— id: 614432, year: 2013, vol: 2, page: 476, stat: Journal Article,

Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy
Seay, Kieran; Qi, Xiaohua; Zheng, Jian Hua; Zhang, Cong; Chen, Ken; Dutta, Monica; Deneroff, Kathryn; Ochsenbauer, Christina; Kappes, John C; Littman, Dan R; Goldstein, Harris
2013 ;8(5):e63537-e63537 e63537, PLoS one
— id: 531522, year: 2013, vol: 8, page: e63537, stat: Journal Article,

Harnessing CD4(+) T cell responses in HIV vaccine development
Streeck, Hendrik; D'Souza, M Patricia; Littman, Dan R; Crotty, Shane
2013 Feb;19(2):143-149, Nature medicine
— id: 531532, year: 2013, vol: 19, page: 143, stat: Journal Article,

A validated regulatory network for th17 cell specification
Ciofani, Maria; Madar, Aviv; Galan, Carolina; Sellars, Maclean; Mace, Kieran; Pauli, Florencia; Agarwal, Ashish; Huang, Wendy; Parkurst, Christopher N; Muratet, Michael; Newberry, Kim M; Meadows, Sarah; Greenfield, Alex; Yang, Yi; Jain, Preti; Kirigin, Francis K; Birchmeier, Carmen; Wagner, Erwin F; Murphy, Kenneth M; Myers, Richard M; Bonneau, Richard; Littman, Dan R
2012 Oct;151(2):289-303, Cell
— id: 180088, year: 2012, vol: 151, page: 289, stat: Journal Article,

Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor RORgammat
Fulton, Leshara M; Carlson, Michael J; Coghill, James M; Ott, Laura E; West, Michelle L; Panoskaltsis-Mortari, Angela; Littman, Dan R; Blazar, Bruce R; Serody, Jonathan S
2012 Aug;189(4):1765-1772, Journal of immunology
— id: 177111, year: 2012, vol: 189, page: 1765, stat: Journal Article,

The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression
Gialitakis, Manolis; Sellars, Maclean; Littman, Dan R
2012 ;356:165-188, Current topics in microbiology & immunology
— id: 162023, year: 2012, vol: 356, page: 165, stat: Journal Article,

A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes
Glasmacher, Elke; Agrawal, Smita; Chang, Abraham B; Murphy, Theresa L; Zeng, Wenwen; Vander Lugt, Bryan; Khan, Aly A; Ciofani, Maria; Spooner, Chauncey J; Rutz, Sascha; Hackney, Jason; Nurieva, Roza; Escalante, Carlos R; Ouyang, Wenjun; Littman, Dan R; Murphy, Kenneth M; Singh, Harinder
2012 Nov;338(6109):975-980, Science
— id: 185542, year: 2012, vol: 338, page: 975, stat: Journal Article,

The microbiome in infectious disease and inflammation
Honda, Kenya; Littman, Dan R
2012 ;30:759-795, Annual review of immunology
— id: 169442, year: 2012, vol: 30, page: 759, stat: Journal Article,

Interactions between the microbiota and the immune system
Hooper, Lora V; Littman, Dan R; Macpherson, Andrew J
2012 Jun;336(6086):1268-1273, Science
— id: 169557, year: 2012, vol: 336, page: 1268, stat: Journal Article,

Small molecule inhibitors of RORgammat: Targeting Th17 cells and other applications
Huh, Jun R; Littman, Dan R
2012 Sep;42(9):2232-2237, European journal of immunology
— id: 177166, year: 2012, vol: 42, page: 2232, stat: Journal Article,

Interleukin 23 Production by Intestinal CD103(+)CD11b(+) Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense
Kinnebrew, Melissa A; Buffie, Charlie G; Diehl, Gretchen E; Zenewicz, Lauren A; Leiner, Ingrid; Hohl, Tobias M; Flavell, Richard A; Littman, Dan R; Pamer, Eric G
2012 Feb;36(2):276-287, Immunity
— id: 159315, year: 2012, vol: 36, page: 276, stat: Journal Article,

Dynamic MicroRNA Gene Transcription and Processing during T Cell Development
Kirigin, Francis F; Lindstedt, Kenneth; Sellars, Maclean; Ciofani, Maria; Low, Siao Li; Jones, Lachlan; Bell, Fiona; Pauli, Florencia; Bonneau, Richard; Myers, Richard M; Littman, Dan R; Chong, Mark M W
2012 Apr;188(7):3257-3267, Journal of immunology
— id: 162835, year: 2012, vol: 188, page: 3257, stat: Journal Article,

Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs
Knuckles, Philip; Vogt, Miriam A; Lugert, Sebastian; Milo, Marta; Chong, Mark M W; Hautbergue, Guillaume M; Wilson, Stuart A; Littman, Dan R; Taylor, Verdon
2012 ;15(7):962-969, Nature neuroscience
— id: 171598, year: 2012, vol: 15, page: 962, stat: Journal Article,

A rare intestinal infection with systemic effects
Longman, Randy S; Moreira, Roger K; Littman, Dan R; Green, Peter H R; Sethi, Amrita
2012 Jan;8(1):60-63, Gastroenterology & hepatology
— id: 158634, year: 2012, vol: 8, page: 60, stat: Journal Article,

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis
Scher, Jose U; Ubeda, Carles; Equinda, Michele; Khanin, Raya; Buischi, Yvonne; Viale, Agnes; Lipuma, Lauren; Attur, Mukundan; Pillinger, Michael H; Weissmann, Gerald; Littman, Dan R; Pamer, Eric G; Bretz, Walter A; Abramson, Steven B
2012 May;:3083-3094, Arthritis & rheumatism
— id: 178156, year: 2012, vol: , page: 3083, stat: Journal Article,

Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin
Teta, Monica; Choi, Yeon Sook; Okegbe, Tishina; Wong, Gabrielle; Tam, Oliver H; Chong, Mark M W; Seykora, John T; Nagy, Andras; Littman, Dan R; Andl, Thomas; Millar, Sarah E
2012 Apr;139(8):1405-1416, Development
— id: 164268, year: 2012, vol: 139, page: 1405, stat: Journal Article,

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Weiss, Jonathan M; Bilate, Angelina M; Gobert, Michael; Ding, Yi; Curotto de Lafaille, Maria A; Parkhurst, Christopher N; Xiong, Huizhong; Dolpady, Jayashree; Frey, Alan B; Ruocco, Maria Grazia; Yang, Yi; Floess, Stefan; Huehn, Jochen; Oh, Soyoung; Li, Ming O; Niec, Rachel E; Rudensky, Alexander Y; Dustin, Michael L; Littman, Dan R; Lafaille, Juan J
2012 Sep;209(10):2291-2299, Journal of experimental medicine
— id: 178843, year: 2012, vol: 209, page: 2291, stat: Journal Article,

Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy
Xu, Cassie; Shen, Yuelei; Littman, Dan R; Dustin, Michael L; Velazquez, Peter
2012 Sep;92(3):413-419, Journal of leukocyte biology
— id: 178144, year: 2012, vol: 92, page: 413, stat: Journal Article,

RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation
Collins, Amelie; Hewitt, Susannah L; Chaumeil, Julie; Sellars, Maclean; Micsinai, Mariann; Allinne, Jeanne; Parisi, Fabio; Nora, Elphege P; Bolland, Dan J; Corcoran, Anne E; Kluger, Yuval; Bosselut, Remy; Ellmeier, Wilfried; Chong, Mark M W; Littman, Dan R; Skok, Jane A
2011 Mar 25;34(3):303-314, Immunity
— id: 129323, year: 2011, vol: 34, page: 303, stat: Journal Article,

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity
Cruz-Orengo, Lillian; Holman, David W; Dorsey, Denise; Zhou, Liang; Zhang, Penglie; Wright, Melissa; McCandless, Erin E; Patel, Jigisha R; Luker, Gary D; Littman, Dan R; Russell, John H; Klein, Robyn S
2011 Feb 14;208(2):327-339, Journal of experimental medicine
— id: 134177, year: 2011, vol: 208, page: 327, stat: Journal Article,

Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene
Egawa, Takeshi; Littman, Dan R
2011 Sep 6;108(36):14873-14878, Proceedings of the National Academy of Sciences of the United States of America
— id: 137074, year: 2011, vol: 108, page: 14873, stat: Journal Article,

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
Hovhannisyan, Zaruhi; Treatman, Jacquelyn; Littman, Dan R; Mayer, Lloyd
2011 Mar;140(3):957-965, Gastroenterology
— id: 134124, year: 2011, vol: 140, page: 957, stat: Journal Article,

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity
Huh, Jun R; Leung, Monica W L; Huang, Pengxiang; Ryan, Daniel A; Krout, Michael R; Malapaka, Raghu R V; Chow, Jonathan; Manel, Nicolas; Ciofani, Maria; Kim, Sangwon V; Cuesta, Adolfo; Santori, Fabio R; Lafaille, Juan J; Xu, H Eric; Gin, David Y; Rastinejad, Fraydoon; Littman, Dan R
2011 Apr 28;472(7344):486-490, Nature
— id: 131813, year: 2011, vol: 472, page: 486, stat: Journal Article,

Modulation of immune homeostasis by commensal bacteria
Ivanov, Ivaylo I; Littman, Dan R
2011 Feb;14(1):106-114, Current opinion in microbiology
— id: 134125, year: 2011, vol: 14, page: 106, stat: Journal Article,

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Kaneko, Hiroki; Dridi, Sami; Tarallo, Valeria; Gelfand, Bradley D; Fowler, Benjamin J; Cho, Won Gil; Kleinman, Mark E; Ponicsan, Steven L; Hauswirth, William W; Chiodo, Vince A; Kariko, Katalin; Yoo, Jae Wook; Lee, Dong-ki; Hadziahmetovic, Majda; Song, Ying; Misra, Smita; Chaudhuri, Gautam; Buaas, Frank W; Braun, Robert E; Hinton, David R; Zhang, Qing; Grossniklaus, Hans E; Provis, Jan M; Madigan, Michele C; Milam, Ann H; Justice, Nikki L; Albuquerque, Romulo J C; Blandford, Alexander D; Bogdanovich, Sasha; Hirano, Yoshio; Witta, Jassir; Fuchs, Elaine; Littman, Dan R; Ambati, Balamurali K; Rudin, Charles M; Chong, Mark M W; Provost, Patrick; Kugel, Jennifer F; Goodrich, James A; Dunaief, Joshua L; Baffi, Judit Z; Ambati, Jayakrishna
2011 Mar 17;471(7338):325-330, Nature
— id: 134204, year: 2011, vol: 471, page: 325, stat: Journal Article,

Role of the commensal microbiota in normal and pathogenic host immune responses
Littman, Dan R; Pamer, Eric G
2011 Oct 4;10(4):311-323, Cell host & microbe
— id: 139746, year: 2011, vol: 10, page: 311, stat: Journal Article,

Hiding in plain sight: how HIV evades innate immune responses
Manel, Nicolas; Littman, Dan R
2011 Oct;147(2):271-274, Cell
— id: 531552, year: 2011, vol: 147, page: 271, stat: Journal Article,

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment
Sczesnak, Andrew; Segata, Nicola; Qin, Xiang; Gevers, Dirk; Petrosino, Joseph F; Huttenhower, Curtis; Littman, Dan R; Ivanov, Ivaylo I
2011 Sep 15;10(3):260-272, Cell host & microbe
— id: 137848, year: 2011, vol: 10, page: 260, stat: Journal Article,

Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells
Sujino, Tomohisa; Kanai, Takanori; Ono, Yuichi; Mikami, Yohei; Hayashi, Atsushi; Doi, Tomomitsu; Matsuoka, Katsuyoshi; Hisamatsu, Tadakazu; Takaishi, Hiromasa; Ogata, Haruhiko; Yoshimura, Akihiko; Littman, Dan R; Hibi, Toshifumi
2011 Sep;141(3):1014-1023, Gastroenterology
— id: 137118, year: 2011, vol: 141, page: 1014, stat: Journal Article,

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy
Zhdanova, Olga; Srivastava, Shekhar; Di, Lie; Li, Zhai; Tchelebi, Leila; Dworkin, Sara; Johnstone, Duncan B; Zavadil, Jiri; Chong, Mark M; Littman, Dan R; Holzman, Lawrence B; Barisoni, Laura; Skolnik, Edward Y
2011 Oct;80(7):719-730, Kidney international
— id: 137467, year: 2011, vol: 80, page: 719, stat: Journal Article,

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
Buonocore, Sofia; Ahern, Philip P; Uhlig, Holm H; Ivanov, Ivaylo I; Littman, Dan R; Maloy, Kevin J; Powrie, Fiona
2010 Apr 29;464(7293):1371-1375, Nature
— id: 137120, year: 2010, vol: 464, page: 1371, stat: Journal Article,

Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
Chong, Mark M W; Simpson, Natalie; Ciofani, Maria; Chen, Grace; Collins, Amelie; Littman, Dan R
2010 Apr 1;24(7):659-669, Genes & development
— id: 109058, year: 2010, vol: 24, page: 659, stat: Journal Article,

Canonical and alternate functions of the microRNA biogenesis machinery
Chong, Mark M W; Zhang, Guoan; Cheloufi, Sihem; Neubert, Thomas A; Hannon, Gregory J; Littman, Dan R
2010 Sep 1;24(17):1951-1960, Genes & development
— id: 112041, year: 2010, vol: 24, page: 1951, stat: Journal Article,

Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection
El Hed, Aimee; Khaitan, Alka; Kozhaya, Lina; Manel, Nicolas; Daskalakis, Demetre; Borkowsky, William; Valentine, Fred; Littman, Dan R; Unutmaz, Derya
2010 Mar 15;201(6):843-854, Journal of infectious diseases
— id: 107380, year: 2010, vol: 201, page: 843, stat: Journal Article,

Segmented filamentous bacteria take the stage
Ivanov, I I; Littman, D R
2010 May;3(3):209-212, Mucosal immunology
— id: 109204, year: 2010, vol: 3, page: 209, stat: Journal Article,

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
Jacob, Bindya; Osato, Motomi; Yamashita, Namiko; Wang, Chelsia Qiuxia; Taniuchi, Ichiro; Littman, Dan R; Asou, Norio; Ito, Yoshiaki
2010 Feb 25;115(8):1610-1620, Blood
— id: 137121, year: 2010, vol: 115, page: 1610, stat: Journal Article,

Flexible use of nuclear import pathways by HIV-1
Lee, KyeongEun; Ambrose, Zandrea; Martin, Thomas D; Oztop, Ilker; Mulky, Alok; Julias, John G; Vandegraaff, Nick; Baumann, Joerg G; Wang, Rui; Yuen, Wendy; Takemura, Taichiro; Shelton, Kenneth; Taniuchi, Ichiro; Li, Yuan; Sodroski, Joseph; Littman, Dan R; Coffin, John M; Hughes, Stephen H; Unutmaz, Derya; Engelman, Alan; KewalRamani, Vineet N
2010 Mar 18;7(3):221-233, Cell host & microbe
— id: 119325, year: 2010, vol: 7, page: 221, stat: Journal Article,

Th17 and regulatory T cells in mediating and restraining inflammation
Littman, Dan R; Rudensky, Alexander Y
2010 Mar 19;140(6):845-858, Cell
— id: 108798, year: 2010, vol: 140, page: 845, stat: Journal Article,

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Manel, Nicolas; Hogstad, Brandon; Wang, Yaming; Levy, David E; Unutmaz, Derya; Littman, Dan R
2010 Sep 9;467(7312):214-217, Nature
— id: 112431, year: 2010, vol: 467, page: 214, stat: Journal Article,

CXCR4 acts as a costimulator during thymic beta-selection
Trampont, Paul C; Tosello-Trampont, Annie-Carole; Shen, Yuelei; Duley, Amanda K; Sutherland, Ann E; Bender, Timothy P; Littman, Dan R; Ravichandran, Kodi S
2010 Feb;11(2):162-170, Nature immunology
— id: 134426, year: 2010, vol: 11, page: 162, stat: Journal Article,

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
Wu, Hsin-Jung; Ivanov, Ivaylo I; Darce, Jaime; Hattori, Kimie; Shima, Tatsuichiro; Umesaki, Yoshinori; Littman, Dan R; Benoist, Christophe; Mathis, Diane
2010 Jun 25;32(6):815-827, Immunity
— id: 137119, year: 2010, vol: 32, page: 815, stat: Journal Article,

Myd88 is required for an antibody response to retroviral infection
Browne, Edward P; Littman, Dan R
2009 Feb;5(2):e1000298-e1000298, PLoS pathogens
— id: 95887, year: 2009, vol: 5, page: e1000298, stat: Journal Article,

RUNX proteins in transcription factor networks that regulate T-cell lineage choice
Collins, Amelie; Littman, Dan R; Taniuchi, Ichiro
2009 Feb;9(2):106-115, Nature reviews. Immunology
— id: 95888, year: 2009, vol: 9, page: 106, stat: Journal Article,

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
Feuerer, Markus; Shen, Yuelei; Littman, Dan R; Benoist, Christophe; Mathis, Diane
2009 Oct 16;31(4):654-664, Immunity
— id: 133735, year: 2009, vol: 31, page: 654, stat: Journal Article,

Induction of intestinal Th17 cells by segmented filamentous bacteria
Ivanov, Ivaylo I; Atarashi, Koji; Manel, Nicolas; Brodie, Eoin L; Shima, Tatsuichiro; Karaoz, Ulas; Wei, Dongguang; Goldfarb, Katherine C; Santee, Clark A; Lynch, Susan V; Tanoue, Takeshi; Imaoka, Akemi; Itoh, Kikuji; Takeda, Kiyoshi; Umesaki, Yoshinori; Honda, Kenya; Littman, Dan R
2009 Oct 30;139(3):485-498, Cell
— id: 105170, year: 2009, vol: 139, page: 485, stat: Journal Article,

Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking
Kim, Joong Kyu; Klinger, Mark; Benjamin, Jonathan; Xiao, Yuanyuan; Erle, David J; Littman, Dan R; Killeen, Nigel
2009 ;4(8):e6580-e6580, PLoS one
— id: 102577, year: 2009, vol: 4, page: e6580, stat: Journal Article,

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
Klunker, Sven; Chong, Mark M W; Mantel, Pierre-Yves; Palomares, Oscar; Bassin, Claudio; Ziegler, Mario; Ruckert, Beate; Meiler, Flurina; Akdis, Mubeccel; Littman, Dan R; Akdis, Cezmi A
2009 Nov 23;206(12):2701-2715, Journal of experimental medicine
— id: 137122, year: 2009, vol: 206, page: 2701, stat: Journal Article,

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
Leppkes, Moritz; Becker, Christoph; Ivanov, Ivaylo I; Hirth, Sebastian; Wirtz, Stefan; Neufert, Clemens; Pouly, Sandrine; Murphy, Andrew J; Valenzuela, David M; Yancopoulos, George D; Becher, Burkhard; Littman, Dan R; Neurath, Markus F
2009 Jan;136(1):257-267, Gastroenterology
— id: 95893, year: 2009, vol: 136, page: 257, stat: Journal Article,

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
Luci, Carmelo; Reynders, Ana; Ivanov, Ivaylo I; Cognet, Celine; Chiche, Laurent; Chasson, Lionel; Hardwigsen, Jean; Anguiano, Esperanza; Banchereau, Jacques; Chaussabel, Damien; Dalod, Marc; Littman, Dan R; Vivier, Eric; Tomasello, Elena
2009 Jan;10(1):75-82, Nature immunology
— id: 95892, year: 2009, vol: 10, page: 75, stat: Journal Article,

Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo
Michel, Nico; Goffinet, Christine; Ganter, Kerstin; Allespach, Ina; Kewalramani, Vineet N; Saifuddin, Mohammed; Littman, Dan R; Greene, Warner C; Goldsmith, Mark A; Keppler, Oliver T
2009 ;6:2-2, Retrovirology
— id: 95889, year: 2009, vol: 6, page: 2, stat: Journal Article,

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
Rudra, Dipayan; Egawa, Takeshi; Chong, Mark M W; Treuting, Piper; Littman, Dan R; Rudensky, Alexander Y
2009 Nov;10(11):1170-1177, Nature immunology
— id: 137123, year: 2009, vol: 10, page: 1170, stat: Journal Article,

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
Takatori, Hiroaki; Kanno, Yuka; Watford, Wendy T; Tato, Cristina M; Weiss, Greta; Ivanov, Ivaylo I; Littman, Dan R; O'Shea, John J
2009 Jan 16;206(1):35-41, Journal of experimental medicine
— id: 95890, year: 2009, vol: 206, page: 35, stat: Journal Article,

Identification of IL-17-producing FOXP3+ regulatory T cells in humans
Voo, Kui Shin; Wang, Yui-Hsi; Santori, Fabio R; Boggiano, Cesar; Wang, Yi-Hong; Arima, Kazuhiko; Bover, Laura; Hanabuchi, Shino; Khalili, Jahan; Marinova, Ekaterina; Zheng, Biao; Littman, Dan R; Liu, Yong-Jun
2009 Mar 24;106(12):4793-4798, Proceedings of the National Academy of Sciences of the United States of America
— id: 95886, year: 2009, vol: 106, page: 4793, stat: Journal Article,

Plasticity of CD4+ T cell lineage differentiation
Zhou, Liang; Chong, Mark M W; Littman, Dan R
2009 May;30(5):646-655, Immunity
— id: 99221, year: 2009, vol: 30, page: 646, stat: Journal Article,

Transcriptional regulatory networks in Th17 cell differentiation
Zhou, Liang; Littman, Dan R
2009 Apr;21(2):146-152, Current opinion in immunology
— id: 100594, year: 2009, vol: 21, page: 146, stat: Journal Article,

Species-specific restriction of apobec3-mediated hypermutation
Browne, Edward P; Littman, Dan R
2008 Feb;82(3):1305-1313, Journal of virology
— id: 75770, year: 2008, vol: 82, page: 1305, stat: Journal Article,

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
Chong, Mark M W; Rasmussen, Jeffrey P; Rudensky, Alexander Y; Littman, Dan R
2008 Sep;205(9):2005-2017, Journal of experimental medicine
— id: 159207, year: 2008, vol: 205, page: 2005, stat: Journal Article,

Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping
Egawa, Takeshi; Kreslavsky, Taras; Littman, Dan R; von Boehmer, Harald
2008 ;3(1):e1512-e1512, PLoS one
— id: 78849, year: 2008, vol: 3, page: e1512, stat: Journal Article,

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
Egawa, Takeshi; Littman, Dan R
2008 Oct;9(10):1131-1139, Nature immunology
— id: 93366, year: 2008, vol: 9, page: 1131, stat: Journal Article,

Multiple ITAM-coupled NK cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-{kappa}B and MAPK activation to selectively control cytokine production
Gross, Olaf; Grupp, Christina; Steinberg, Christian; Zimmermann, Stephanie; Strasser, Dominikus; Hannesschlager, Nicole; Reindl, Wolfgang; Jonsson, Helena; Huo, Hairong; Littman, Dan R; Peschel, Christian; Yokoyama, Wayne M; Krug, Anne; Ruland, Jurgen
2008 Sep 15;112(6):2421-2428, Blood
— id: 78850, year: 2008, vol: 112, page: 2421, stat: Journal Article,

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
Ivanov, Ivaylo I; Frutos, Rosa de Llanos; Manel, Nicolas; Yoshinaga, Keiji; Rifkin, Daniel B; Sartor, R Balfour; Finlay, B Brett; Littman, Dan R
2008 Oct 16;4(4):337-349, Cell host & microbe
— id: 93379, year: 2008, vol: 4, page: 337, stat: Journal Article,

Regulated movement of CD4 in and out of the immunological synapse
Kao, Henry; Lin, Joseph; Littman, Dan R; Shaw, Andrey S; Allen, Paul M
2008 Dec 15;181(12):8248-8257, Journal of immunology
— id: 95891, year: 2008, vol: 181, page: 8248, stat: Journal Article,

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
Manel, Nicolas; Unutmaz, Derya; Littman, Dan R
2008 Jun;9(6):641-649, Nature immunology
— id: 78844, year: 2008, vol: 9, page: 641, stat: Journal Article,

HIV immunology needs a new direction
Medzhitov, Ruslan; Littman, Dan
2008 Oct 2;455(7213):591-591, Nature
— id: 137124, year: 2008, vol: 455, page: 591, stat: Journal Article,

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
Quezada, Sergio A; Peggs, Karl S; Simpson, Tyler R; Shen, Yuelei; Littman, Dan R; Allison, James P
2008 Sep 1;205(9):2125-2138, Journal of experimental medicine
— id: 95895, year: 2008, vol: 205, page: 2125, stat: Journal Article,

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone
Scandella, Elke; Bolinger, Beatrice; Lattmann, Evelyn; Miller, Simone; Favre, Stephanie; Littman, Dan R; Finke, Daniela; Luther, Sanjiv A; Junt, Tobias; Ludewig, Burkhard
2008 Jun;9(6):667-675, Nature immunology
— id: 78846, year: 2008, vol: 9, page: 667, stat: Journal Article,

NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion
Tassi, Ilaria; Cella, Marina; Presti, Rachel; Colucci, Angela; Gilfillan, Susan; Littman, Dan R; Colonna, Marco
2008 Nov 15;112(10):4109-4116, Blood
— id: 95894, year: 2008, vol: 112, page: 4109, stat: Journal Article,

Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
Tsuji, Masayuki; Suzuki, Keiichiro; Kitamura, Hiroshi; Maruya, Mikako; Kinoshita, Kazuo; Ivanov, Ivaylo I; Itoh, Kikuji; Littman, Dan R; Fagarasan, Sidonia
2008 Aug;29(2):261-271, Immunity
— id: 95896, year: 2008, vol: 29, page: 261, stat: Journal Article,

Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection
Valdez, Yanet; Diehl, Gretchen E; Vallance, Bruce A; Grassl, Guntram A; Guttman, Julian A; Brown, Nat F; Rosenberger, Carrie M; Littman, Dan R; Gros, Philippe; Finlay, B Brett
2008 Aug;10(8):1646-1661, Cellular microbiology
— id: 78847, year: 2008, vol: 10, page: 1646, stat: Journal Article,

Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells
Zhang, Jing-xin; Diehl, Gretchen E; Littman, Dan R
2008 ;3(4):e2035-e2035, PLoS one
— id: 78845, year: 2008, vol: 3, page: e2035, stat: Journal Article,

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
Zhou, Liang; Lopes, Jared E; Chong, Mark M W; Ivanov, Ivaylo I; Min, Roy; Victora, Gabriel D; Shen, Yuelei; Du, Jianguang; Rubtsov, Yuri P; Rudensky, Alexander Y; Ziegler, Steven F; Littman, Dan R
2008 May 8;453(7192):236-240, Nature
— id: 78848, year: 2008, vol: 453, page: 236, stat: Journal Article,

HIV's vagina travelogue
Boggiano, Cesar; Littman, Dan R
2007 Feb;26(2):145-147, Immunity
— id: 71929, year: 2007, vol: 26, page: 145, stat: Journal Article,

Dendritic cell-mediated trans-enhancement of HIV-1 infectivity is independent of DC-SIGN
Boggiano, Cesar; Manel, Nicolas; Littman, Dan R
2007 Mar;81(5):2519-2523, Journal of virology
— id: 69501, year: 2007, vol: 81, page: 2519, stat: Journal Article,

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
Egawa, Takeshi; Tillman, Robert E; Naoe, Yoshinori; Taniuchi, Ichiro; Littman, Dan R
2007 Aug 6;204(8):1945-1957, Journal of experimental medicine
— id: 73912, year: 2007, vol: 204, page: 1945, stat: Journal Article,

Transcriptional regulation of Th17 cell differentiation
Ivanov, Ivaylo I; Zhou, Liang; Littman, Dan R
2007 Dec;19(6):409-417, Seminars in immunology
— id: 78851, year: 2007, vol: 19, page: 409, stat: Journal Article,

Immunology. Asymmetry and immune memory
Littman, Dan R; Singh, Harinder
2007 Mar 23;315(5819):1673-1674, Science
— id: 71351, year: 2007, vol: 315, page: 1673, stat: Journal Article,

Asymmetry and immune memory
Littman, DR; Singh, H
2007 ;315(5819):1673-1674, Science
— id: 644062, year: 2007, vol: 315, page: 1673, stat: Journal Article,

Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation
Misra, Ravi S; Russell, Jennifer Q; Koenig, Andreas; Hinshaw-Makepeace, Jennifer A; Wen, Renren; Wang, Demin; Huo, Hairong; Littman, Dan R; Ferch, Uta; Ruland, Jurgen; Thome, Margot; Budd, Ralph C
2007 Jul 6;282(27):19365-19374, Journal of biological chemistry
— id: 78853, year: 2007, vol: 282, page: 19365, stat: Journal Article,

Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult
Motoda, Lena; Osato, Motomi; Yamashita, Namiko; Jacob, Bindya; Chen, Lynnette Q; Yanagida, Masatoshi; Ida, Hiroshi; Wee, Hee-Jun; Sun, Alfred X; Taniuchi, Ichiro; Littman, Dan; Ito, Yoshiaki
2007 Dec;25(12):2976-2986, Stem cells
— id: 78852, year: 2007, vol: 25, page: 2976, stat: Journal Article,

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
Naoe, Yoshinori; Setoguchi, Ruka; Akiyama, Kaori; Muroi, Sawako; Kuroda, Masahiko; Hatam, Farah; Littman, Dan R; Taniuchi, Ichiro
2007 Aug 6;204(8):1749-1755, Journal of experimental medicine
— id: 73914, year: 2007, vol: 204, page: 1749, stat: Journal Article,

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse
Sims, Tasha N; Soos, Timothy J; Xenias, Harry S; Dubin-Thaler, Benjamin; Hofman, Jake M; Waite, Janelle C; Cameron, Thomas O; Thomas, V Kaye; Varma, Rajat; Wiggins, Chris H; Sheetz, Michael P; Littman, Dan R; Dustin, Michael L
2007 May 18;129(4):773-785, Cell
— id: 73235, year: 2007, vol: 129, page: 773, stat: Journal Article,

Opposing Effects of PKC? and WASp on Symmetry Breaking and Relocation of the Immunological Synapse
Sims, TN; Soos, TJ; Xenias, HS; Dubin-Thaler, B; Hofman, JM; Waite, JC; Cameron, TO; Thomas, VK; Varma, R; Wiggins, CH; Sheetz, MP; Littman, DR; Dustin, ML
2007 ;129(4):773-785, Cell
— id: 643772, year: 2007, vol: 129, page: 773, stat: Journal Article,

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Zhou, Liang; Ivanov, Ivaylo I; Spolski, Rosanne; Min, Roy; Shenderov, Kevin; Egawa, Takeshi; Levy, David E; Leonard, Warren J; Littman, Dan R
2007 Sep;8(9):967-974, Nature immunology
— id: 74681, year: 2007, vol: 8, page: 967, stat: Journal Article,

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
Burns, Jennifer M; Summers, Bretton C; Wang, Yu; Melikian, Anita; Berahovich, Rob; Miao, Zhenhua; Penfold, Mark E T; Sunshine, Mary Jean; Littman, Dan R; Kuo, Calvin J; Wei, Kevin; McMaster, Brian E; Wright, Kim; Howard, Maureen C; Schall, Thomas J
2006 Sep 4;203(9):2201-2213, Journal of experimental medicine
— id: 69502, year: 2006, vol: 203, page: 2201, stat: Journal Article,

Control of microglial neurotoxicity by the fractalkine receptor
Cardona, Astrid E; Pioro, Erik P; Sasse, Margaret E; Kostenko, Volodymyr; Cardona, Sandra M; Dijkstra, Ineke M; Huang, Deren; Kidd, Grahame; Dombrowski, Stephen; Dutta, RanJan; Lee, Jar-Chi; Cook, Donald N; Jung, Steffen; Lira, Sergio A; Littman, Dan R; Ransohoff, Richard M
2006 Jul;9(7):917-924, Nature neuroscience
— id: 69503, year: 2006, vol: 9, page: 917, stat: Journal Article,

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
Fogg, Darin K; Sibon, Claire; Miled, Chaouki; Jung, Steffen; Aucouturier, Pierre; Littman, Dan R; Cumano, Ana; Geissmann, Frederic
2006 Jan 6;311(5757):83-87, Science
— id: 69506, year: 2006, vol: 311, page: 83, stat: Journal Article,

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells (vol 311, pg 1908, 2005)
Fogg, DK; Sibon, C; Miled, C; Jung, S; Aucouturier, P; Littman, DR; Cumano, A; Geissmann, F
2006 MAR 3 ;311(5765):1242-1242, Science
— id: 62766, year: 2006, vol: 311, page: 1242, stat: Journal Article,

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system
Huang, DeRen; Shi, Fu-Dong; Jung, Steffen; Pien, Gary C; Wang, Jintang; Salazar-Mather, Thais P; He, Toby T; Weaver, Jennifer T; Ljunggren, Hans-Gustaf; Biron, Christine A; Littman, Dan R; Ransohoff, Richard M
2006 May;20(7):896-905, FASEB journal
— id: 69504, year: 2006, vol: 20, page: 896, stat: Journal Article,

Lymphoid tissue inducer cells in intestinal immunity
Ivanov, I I; Diehl, G E; Littman, D R
2006 ;308:59-82, Current topics in microbiology & immunology
— id: 68779, year: 2006, vol: 308, page: 59, stat: Journal Article,

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivanov, Ivaylo I; McKenzie, Brent S; Zhou, Liang; Tadokoro, Carlos E; Lepelley, Alice; Lafaille, Juan J; Cua, Daniel J; Littman, Dan R
2006 Sep 22;126(6):1121-1133, Cell
— id: 69079, year: 2006, vol: 126, page: 1121, stat: Journal Article,

CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney
Soos, T J; Sims, T N; Barisoni, L; Lin, K; Littman, D R; Dustin, M L; Nelson, P J
2006 Aug;70(3):591-596, Kidney international
— id: 66675, year: 2006, vol: 70, page: 591, stat: Journal Article,

CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate
Sun, Jinglin; Soos, Timothy; Kewalramani, Vineet N; Osiecki, Kristin; Zheng, Jian Hua; Falkin, Laurie; Santambrogio, Laura; Littman, Dan R; Goldstein, Harris
2006 Feb;80(4):1850-1862, Journal of virology
— id: 69505, year: 2006, vol: 80, page: 1850, stat: Journal Article,

Virus-host interactions: new insights from the small RNA world
Browne, Edward P; Li, Junjie; Chong, Mark; Littman, Dan R
2005 ;6(11):238-238, Genome biology
— id: 64454, year: 2005, vol: 6, page: 238, stat: Journal Article,

Selection and lineage specification in the thymus: commitment 4-stalled
Collins, Amelie; Littman, Dan R
2005 Jul;23(1):4-5, Immunity
— id: 57847, year: 2005, vol: 23, page: 4, stat: Journal Article,

ATP mediates rapid microglial response to local brain injury in vivo
Davalos, Dimitrios; Grutzendler, Jaime; Yang, Guang; Kim, Jiyun V; Zuo, Yi; Jung, Steffen; Littman, Dan R; Dustin, Michael L; Gan, Wen-Biao
2005 Jun;8(6):752-758, Nature neuroscience
— id: 56024, year: 2005, vol: 8, page: 752, stat: Journal Article,

Response to comment on "Thymic origin of intestinal up T cells revealed by fate mapping of ROR gamma t(+) cells"
Eberl, G; Littman, DR
2005 JUN 10 ;308(5728):45-54, Science
— id: 55929, year: 2005, vol: 308, page: 45, stat: Journal Article,

Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
Egawa, Takeshi; Eberl, Gerard; Taniuchi, Ichiro; Benlagha, Kamel; Geissmann, Frederic; Hennighausen, Lothar; Bendelac, Albert; Littman, Dan R
2005 Jun;22(6):705-716, Immunity
— id: 69511, year: 2005, vol: 22, page: 705, stat: Journal Article,

Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development
Feik, Nicholas; Bilic, Ivan; Tinhofer, Johanna; Unger, Bernd; Littman, Dan R; Ellmeier, Wilfried
2005 Feb 1;174(3):1513-1524, Journal of immunology
— id: 69512, year: 2005, vol: 174, page: 1513, stat: Journal Article,

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells
Grueter, Baerbel; Petter, Michaela; Egawa, Takeshi; Laule-Kilian, Kirsten; Aldrian, Christine J; Wuerch, Andreas; Ludwig, Yvonne; Fukuyama, Hidehiro; Wardemann, Hedda; Waldschuetz, Ralph; Moroy, Tarik; Taniuchi, Ichiro; Steimle, Viktor; Littman, Dan R; Ehlers, Marc
2005 Aug 1;175(3):1694-1705, Journal of immunology
— id: 69510, year: 2005, vol: 175, page: 1694, stat: Journal Article,

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
Niess, Jan Hendrik; Brand, Stephan; Gu, Xiubin; Landsman, Limor; Jung, Steffen; McCormick, Beth A; Vyas, Jatin M; Boes, Marianne; Ploegh, Hidde L; Fox, James G; Littman, Dan R; Reinecker, Hans-Christian
2005 Jan 14;307(5707):254-258, Science
— id: 69513, year: 2005, vol: 307, page: 254, stat: Journal Article,

Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis
Odemis, Veysel; Lamp, Elke; Pezeshki, Gita; Moepps, Barbara; Schilling, Karl; Gierschik, Peter; Littman, Dan R; Engele, Jurgen
2005 Dec;30(4):494-505, Molecular & cellular neurosciences
— id: 69509, year: 2005, vol: 30, page: 494, stat: Journal Article,

Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver
Sato, Tohru; Thorlacius, Henrik; Johnston, Brent; Staton, Tracy L; Xiang, Wenkai; Littman, Dan R; Butcher, Eugene C
2005 Jan 1;174(1):277-283, Journal of immunology
— id: 69514, year: 2005, vol: 174, page: 277, stat: Journal Article,

The SDF-1/CXCR4 pathway and the development of the cerebellar system
Vilz, Tim O; Moepps, Barbara; Engele, Jurgen; Molly, Sabine; Littman, Dan R; Schilling, Karl
2005 Oct;22(8):1831-1839, European journal of neuroscience
— id: 69508, year: 2005, vol: 22, page: 1831, stat: Journal Article,

Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
Wang, Xiaoxia; Blagden, Chris; Fan, Jihua; Nowak, Scott J; Taniuchi, Ichiro; Littman, Dan R; Burden, Steven J
2005 Jul 15;19(14):1715-1722, Genes & development
— id: 57720, year: 2005, vol: 19, page: 1715, stat: Journal Article,

CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells
Zaft, Tami; Sapoznikov, Anita; Krauthgamer, Rita; Littman, Dan R; Jung, Steffen
2005 Nov 15;175(10):6428-6435, Journal of immunology
— id: 69507, year: 2005, vol: 175, page: 6428, stat: Journal Article,

Murine T cells potently restrict human immunodeficiency virus infection
Baumann, Jorg G; Unutmaz, Derya; Miller, Michael D; Breun, Sabine K J; Grill, Stacy M; Mirro, Jane; Littman, Dan R; Rein, Alan; KewalRamani, Vineet N
2004 Nov;78(22):12537-12547, Journal of virology
— id: 69516, year: 2004, vol: 78, page: 12537, stat: Journal Article,

PKC{theta} Signals Activation versus Tolerance In Vivo
Berg-Brown, Nancy N; Gronski, Matthew A; Jones, Russell G; Elford, Alisha R; Deenick, Elissa K; Odermatt, Bernhard; Littman, Dan R; Ohashi, Pamela S
2004 Mar 15;199(6):743-752, Journal of experimental medicine
— id: 42239, year: 2004, vol: 199, page: 743, stat: Journal Article,

Role of fractalkine and fractalkine receptor in microglia neurotoxicity
Cardona, AE; Huang, D; Kidd, G; Sasse, ME; Lira, S; Cook, D; Jung, S; Littman, DR; Ransohoff, RM
2004 MAY ;63(5):525-525, Journal of neuropathology & experimental neurology
— id: 46514, year: 2004, vol: 63, page: 525, stat: Journal Article,

Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells
Eberl, Gerard; Littman, Dan R
2004 Aug 9;305(5681):248-251, Science
— id: 46159, year: 2004, vol: 305, page: 248, stat: Journal Article,

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
Eberl, Gerard; Marmon, Shana; Sunshine, Mary-Jean; Rennert, Paul D; Choi, Yongwon; Littman, Dan R
2004 Jan;5(1):64-73, Nature immunology
— id: 42235, year: 2004, vol: 5, page: 64, stat: Journal Article,

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells
Fonteneau, Jean-Francois; Larsson, Marie; Beignon, Anne-Sophie; McKenna, Kelli; Dasilva, Ida; Amara, Ali; Liu, Yong-Jun; Lifson, Jeffrey D; Littman, Dan R; Bhardwaj, Nina
2004 May;78(10):5223-5232, Journal of virology
— id: 44440, year: 2004, vol: 78, page: 5223, stat: Journal Article,

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
Kawakami, Yuko; Nishimoto, Hajime; Kitaura, Jiro; Maeda-Yamamoto, Mari; Kato, Roberta M; Littman, Dan R; Leitges, Michael; Rawlings, David J; Kawakami, Toshiaki
2004 Nov 12;279(46):47720-47725, Journal of biological chemistry
— id: 69519, year: 2004, vol: 279, page: 47720, stat: Journal Article,

PKC-theta knockout mice are protected from fat-induced insulin resistance
Kim, Jason K; Fillmore, Jonathan J; Sunshine, Mary Jean; Albrecht, Bjoern; Higashimori, Takamasa; Kim, Dong-Wook; Liu, Zhen-Xiang; Soos, Timothy J; Cline, Gary W; O'Brien, William R; Littman, Dan R; Shulman, Gerald I
2004 Sep;114(6):823-827, Journal of clinical investigation
— id: 69517, year: 2004, vol: 114, page: 823, stat: Journal Article,

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
Li, Yu; Soos, Timothy J; Li, Xinghai; Wu, Jiong; Degennaro, Matthew; Sun, Xiaojian; Littman, Dan R; Birnbaum, Morris J; Polakiewicz, Roberto D
2004 Oct 29;279(44):45304-45307, Journal of biological chemistry
— id: 69518, year: 2004, vol: 279, page: 45304, stat: Journal Article,

CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors
Madakamutil, Loui T; Christen, Urs; Lena, Christopher J; Wang-Zhu, Yiran; Attinger, Antoine; Sundarrajan, Monisha; Ellmeier, Wilfried; von Herrath, Matthias G; Jensen, Peter; Littman, Dan R; Cheroutre, Hilde
2004 Apr 23;304(5670):590-593, Science
— id: 69523, year: 2004, vol: 304, page: 590, stat: Journal Article,

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses
Marsland, Benjamin J; Soos, Timothy J; Spath, Gerald; Littman, Dan R; Kopf, Manfred
2004 Jul 19;200(2):181-189, Journal of experimental medicine
— id: 69520, year: 2004, vol: 200, page: 181, stat: Journal Article,

The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity
Nie, Yuchun; Waite, Janelle; Brewer, Faraha; Sunshine, Mary-Jean; Littman, Dan R; Zou, Yong-Rui
2004 Nov 1;200(9):1145-1156, Journal of experimental medicine
— id: 69515, year: 2004, vol: 200, page: 1145, stat: Journal Article,

The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development
Taniuchi, Ichiro; Ellmeier, Wilfried; Littman, Dan R
2004 ;83:55-89, Advances in immunology
— id: 69522, year: 2004, vol: 83, page: 55, stat: Journal Article,

Epigenetic gene silencing by Runx proteins
Taniuchi, Ichiro; Littman, Dan R
2004 May 24;23(24):4341-4345, Oncogene
— id: 69521, year: 2004, vol: 23, page: 4341, stat: Journal Article,

After Hrs with HIV
Amara, Ali; Littman, Dan R
2003 Aug 4;162(3):371-375, Journal of cell biology
— id: 39117, year: 2003, vol: 162, page: 371, stat: Journal Article,

The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells
Chalasani, Sreekanth H; Baribaud, Frederic; Coughlan, Christine M; Sunshine, Mary J; Lee, Virginia M Y; Doms, Robert W; Littman, Dan R; Raper, Jonathan A
2003 Jun 1;23(11):4601-4612, Journal of neuroscience
— id: 42236, year: 2003, vol: 23, page: 4601, stat: Journal Article,

A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding
Chalasani, Sreekanth H; Sabelko, Kimberly A; Sunshine, Mary J; Littman, Dan R; Raper, Jonathan A
2003 Feb 15;23(4):1360-1371, Journal of neuroscience
— id: 42237, year: 2003, vol: 23, page: 1360, stat: Journal Article,

The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches
Eberl, Gerard; Littman, Dan R
2003 Oct;195(19):81-90, Immunological reviews
— id: 39077, year: 2003, vol: 195, page: 81, stat: Journal Article,

Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
Egawa, Takeshi; Albrecht, Bjorn; Favier, Benoit; Sunshine, Mary-Jean; Mirchandani, Kanchan; O'Brien, William; Thome, Margot; Littman, Dan R
2003 Jul 15;13(14):1252-1258, Current biology. CB
— id: 39138, year: 2003, vol: 13, page: 1252, stat: Journal Article,

Blood monocytes consist of two principal subsets with distinct migratory properties
Geissmann, Frederic; Jung, Steffen; Littman, Dan R
2003 Jul;19(1):71-82, Immunity
— id: 39135, year: 2003, vol: 19, page: 71, stat: Journal Article,

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Huo, Yuqing; Schober, Andreas; Forlow, S Bradley; Smith, David F; Hyman, Matthew Craig; Jung, Steffen; Littman, Dan R; Weber, Christian; Ley, Klaus
2003 Jan;9(1):61-67, Nature medicine
— id: 42238, year: 2003, vol: 9, page: 61, stat: Journal Article,

The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival
Molyneaux, Kathleen A; Zinszner, Helene; Kunwar, Prabhat S; Schaible, Kyle; Stebler, Jurg; Sunshine, Mary Jean; O'Brien, William; Raz, Erez; Littman, Dan; Wylie, Chris; Lehmann, Ruth
2003 Sep;130(18):4279-4286, Development
— id: 52649, year: 2003, vol: 130, page: 4279, stat: Journal Article,

Protein kinase C-theta;: signaling from the center of the T-cell synapse
Arendt, Christopher W; Albrecht, Bjorn; Soos, Timothy J; Littman, Dan R
2002 Jun;14(3):323-330, Current opinion in immunology
— id: 32454, year: 2002, vol: 14, page: 323, stat: Journal Article,

The chemokine SDF1 regulates migration of dentate granule cells
Bagri, Anil; Gurney, Theresa; He, Xiaoping; Zou, Yong-Rui; Littman, Dan R; Tessier-Lavigne, Marc; Pleasure, Samuel J
2002 Sep;129(18):4249-4260, Development
— id: 69525, year: 2002, vol: 129, page: 4249, stat: Journal Article,

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
Chi, Tian H; Wan, Mimi; Zhao, Keji; Taniuchi, Ichiro; Chen, Lei; Littman, Dan R; Crabtree, Gerald R
2002 Jul 11;418(6894):195-199, Nature
— id: 69526, year: 2002, vol: 418, page: 195, stat: Journal Article,

Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression
Ellmeier, Wilfried; Sunshine, Mary Jean; Maschek, Romana; Littman, Dan R
2002 May;16(5):623-634, Immunity
— id: 69528, year: 2002, vol: 16, page: 623, stat: Journal Article,

Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes
Guo, Jian; Hawwari, Abbas; Li, Hong; Sun, Zuoming; Mahanta, Sanjeev K; Littman, Dan R; Krangel, Michael S; He, You-Wen
2002 May;3(5):469-476, Nature immunology
— id: 69530, year: 2002, vol: 3, page: 469, stat: Journal Article,

Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent
Harmsen, Allen; Kusser, Kimberley; Hartson, Louise; Tighe, Michael; Sunshine, Mary Jean; Sedgwick, Jonathon D; Choi, Yongwon; Littman, Dan R; Randall, Troy D
2002 Feb 1;168(3):986-990, Journal of immunology
— id: 69532, year: 2002, vol: 168, page: 986, stat: Journal Article,

In Vivo Depletion of CD11c(+) Dendritic Cells Abrogates Priming of CD8(+) T Cells by Exogenous Cell-Associated Antigens
Jung, Steffen; Unutmaz, Derya; Wong, Phillip; Sano, Gen-Ichiro; De los Santos, Kenia; Sparwasser, Tim; Wu, Shengji; Vuthoori, Sri; Ko, Kyung; Zavala, Fidel; Pamer, Eric G; Littman, Dan R; Lang, Richard A
2002 Aug;17(2):211-220, Immunity
— id: 32272, year: 2002, vol: 17, page: 211, stat: Journal Article,

Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1
Keppler, Oliver T; Welte, Frank J; Ngo, Tuan A; Chin, Peggy S; Patton, Kathryn S; Tsou, Chia-Lin; Abbey, Nancy W; Sharkey, Mark E; Grant, Robert M; You, Yun; Scarborough, John D; Ellmeier, Wilfried; Littman, Dan R; Stevenson, Mario; Charo, Israel F; Herndier, Brian G; Speck, Roberto F; Goldsmith, Mark A
2002 Mar 18;195(6):719-736, Journal of experimental medicine
— id: 69531, year: 2002, vol: 195, page: 719, stat: Journal Article,

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection
Kwon, Douglas S; Gregorio, Glenn; Bitton, Natacha; Hendrickson, Wayne A; Littman, Dan R
2002 Jan;16(1):135-144, Immunity
— id: 39719, year: 2002, vol: 16, page: 135, stat: Journal Article,

Epigenetic Regulation in T Cell Development
Littman, Dan
[S.l.] : NIH, 2002,
— id: 1424, year: 2002, vol: , page: , stat: ,

Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice
Ohlrogge, Wiebke; Haag, Friedrich; Lohler, Jurgen; Seman, Michel; Littman, Dan R; Killeen, Nigel; Koch-Nolte, Friedrich
2002 Nov;22(21):7535-7542, Molecular & cellular biology
— id: 69524, year: 2002, vol: 22, page: 7535, stat: Journal Article,

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches
Okada, Takaharu; Ngo, Vu N; Ekland, Eric H; Forster, Reinhold; Lipp, Martin; Littman, Dan R; Cyster, Jason G
2002 Jul 1;196(1):65-75, Journal of experimental medicine
— id: 69527, year: 2002, vol: 196, page: 65, stat: Journal Article,

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
Taniuchi, Ichiro; Osato, Motomi; Egawa, Takeshi; Sunshine, Mary Jean; Bae, Suk Chul; Komori, Toshihisa; Ito, Yoshiaki; Littman, Dan R
2002 Nov 27;111(5):621-633, Cell
— id: 39359, year: 2002, vol: 111, page: 621, stat: Journal Article,

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
Taniuchi, Ichiro; Sunshine, Mary Jean; Festenstein, Richard; Littman, Dan R
2002 Nov;10(5):1083-1096, Molecular cell
— id: 39365, year: 2002, vol: 10, page: 1083, stat: Journal Article,

Nuclear hormone receptors in T lymphocytes
Winoto, Astar; Littman, Dan R
2002 Apr;109 Suppl:S57-S66, Cell
— id: 69529, year: 2002, vol: 109 Suppl, page: S57, stat: Journal Article,

HIV: master of the host cell
Arendt CW; Littman DR
2001 ;2(11):REVIEWS1030-REVIEWS1030, Genome biology
— id: 26504, year: 2001, vol: 2, page: REVIEWS1030, stat: Journal Article,

Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN
Baribaud, F; Pohlmann, S; Sparwasser, T; Kimata, M T; Choi, Y K; Haggarty, B S; Ahmad, N; Macfarlan, T; Edwards, T G; Leslie, G J; Arnason, J; Reinhart, T A; Kimata, J T; Littman, D R; Hoxie, J A; Doms, R W
2001 Nov;75(21):10281-10289, Journal of virology
— id: 531582, year: 2001, vol: 75, page: 10281, stat: Journal Article,

Human GLI-2 is a tat activation response element-independent Tat cofactor
Browning, C M; Smith, M J; Clark, N M; Lane, B R; Parada, C; Montano, M; KewalRamani, V N; Littman, D R; Essex, M; Roeder, R G; Markovitz, D M
2001 Mar;75(5):2314-2323, Journal of virology
— id: 531602, year: 2001, vol: 75, page: 2314, stat: Journal Article,

A coordinated change in chemokine responsiveness guides plasma cell movements
Hargreaves, D C; Hyman, P L; Lu, T T; Ngo, V N; Bidgol, A; Suzuki, G; Zou, Y R; Littman, D R; Cyster, J G
2001 Jul;194(1):45-56, Journal of experimental medicine
— id: 531592, year: 2001, vol: 194, page: 45, stat: Journal Article,

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium
Huo, Y; Weber, C; Forlow, S B; Sperandio, M; Thatte, J; Mack, M; Jung, S; Littman, D R; Ley, K
2001 Nov;108(9):1307-1314, Journal of clinical investigation
— id: 531572, year: 2001, vol: 108, page: 1307, stat: Journal Article,

Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues
Palframan, R T; Jung, S; Cheng, G; Weninger, W; Luo, Y; Dorf, M; Littman, D R; Rollins, B J; Zweerink, H; Rot, A; von Andrian, U H
2001 Nov;194(9):1361-1373, Journal of experimental medicine
— id: 531562, year: 2001, vol: 194, page: 1361, stat: Journal Article,

Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
Pierani, A; Moran-Rivard, L; Sunshine, M J; Littman, D R; Goulding, M; Jessell, T M
2001 Feb;29(2):367-384, Neuron
— id: 104486, year: 2001, vol: 29, page: 367, stat: Journal Article,

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
Wolfer, A; Bakker, T; Wilson, A; Nicolas, M; Ioannidis, V; Littman, D R; Lee, P P; Wilson, C B; Held, W; MacDonald, H R; Radtke, F
2001 Mar;2(3):235-241, Nature immunology
— id: 531612, year: 2001, vol: 2, page: 235, stat: Journal Article,

Inactivation of Notch I in immature thymocytes does not perturb CD4 or CD8T cell development
Wolfer, A; Bakker, T; Wilson, A; Nicolas, M; Ioannidis, V; Littman, DR; Wilson, CB; Held, W; MacDonald, HR; Radtke, F
2001 MAR ;2(3):235-241, Nature immunology
— id: 55143, year: 2001, vol: 2, page: 235, stat: Journal Article,

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
Zou YR; Sunshine MJ; Taniuchi I; Hatam F; Killeen N; Littman DR
2001 Nov;29(3):332-336, Nature genetics
— id: 26588, year: 2001, vol: 29, page: 332, stat: Journal Article,

Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk [In Process Citation]
Ellmeier W; Jung S; Sunshine MJ; Hatam F; Xu Y; Baltimore D; Mano H; Littman DR
2000 Dec 4;192(11):1611-1624, Journal of experimental medicine
— id: 15113, year: 2000, vol: 192, page: 1611, stat: Journal Article,

Severe B cell-deficiency in mice lacking the Tec kinase family members Btk and Tec
Ellmeier, W; Sunshine, M J; Jung, S; Xu, Y; Baltimore, D; Mano, H; Littman, D R
2000 Sept 23-26;73(2-3):131-131, Immunology letters
— id: 15800, year: 2000, vol: 73, page: 131, stat: Journal Article,

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells [see comments]
Geijtenbeek TB; Kwon DS; Torensma R; van Vliet SJ; van Duijnhoven GC; Middel J; Cornelissen IL; Nottet HS; KewalRamani VN; Littman DR; Figdor CG; van Kooyk Y
2000 Mar 3;100(5):587-597, Cell
— id: 8528, year: 2000, vol: 100, page: 587, stat: Journal Article,

Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway
Gu C; Ma YC; Benjamin J; Littman D; Chao MV; Huang XY
2000 Jul 7;275(27):20726-20733, Journal of biological chemistry
— id: 14641, year: 2000, vol: 275, page: 20726, stat: Journal Article,

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
Jung S; Aliberti J; Graemmel P; Sunshine MJ; Kreutzberg GW; Sher A; Littman DR
2000 Jun;20(11):4106-4114, Molecular & cellular biology
— id: 11707, year: 2000, vol: 20, page: 4106, stat: Journal Article,

PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
Sun Z; Arendt CW; Ellmeier W; Schaeffer EM; Sunshine MJ; Gandhi L; Annes J; Petrzilka D; Kupfer A; Schwartzberg PL; Littman DR
2000 Mar 23;404(6776):402-407, Nature
— id: 11778, year: 2000, vol: 404, page: 402, stat: Journal Article,

Requirement for RORgamma in thymocyte survival and lymphoid organ development
Sun Z; Unutmaz D; Zou YR; Sunshine MJ; Pierani A; Brenner-Morton S; Mebius RE; Littman DR
2000 Jun 30;288(5475):2369-2373, Science
— id: 11628, year: 2000, vol: 288, page: 2369, stat: Journal Article,

The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern Is conserved between human and mouse [In Process Citation]
Unutmaz D; Xiang W; Sunshine MJ; Campbell J; Butcher E; Littman DR
2000 Sep 15;165(6):3284-3292, Journal of immunology
— id: 11512, year: 2000, vol: 165, page: 3284, stat: Journal Article,

The regulation of CD4 and CD8 coreceptor gene expression during T cell development
Ellmeier W; Sawada S; Littman DR
1999 ;17:523-554, Annual review of immunology
— id: 6131, year: 1999, vol: 17, page: 523, stat: Journal Article,

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells
Fowell DJ; Shinkai K; Liao XC; Beebe AM; Coffman RL; Littman DR; Locksley RM
1999 Oct;11(4):399-409, Immunity
— id: 15114, year: 1999, vol: 11, page: 399, stat: Journal Article,

Chemokine receptors in lymphoid organ homeostasis
Jung S; Littman DR
1999 Jun;11(3):319-325, Current opinion in immunology
— id: 6143, year: 1999, vol: 11, page: 319, stat: Journal Article,

Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne
Kimata JT; Gosink JJ; KewalRamani VN; Rudensey LM; Littman DR; Overbaugh J
1999 Feb;73(2):1655-1660, Journal of virology
— id: 57042, year: 1999, vol: 73, page: 1655, stat: Journal Article,

Fusion-competent vaccines: broad neutralization of primary isolates of HIV
LaCasse RA; Follis KE; Trahey M; Scarborough JD; Littman DR; Nunberg JH
1999 Jan 15;283(5400):357-362, Science
— id: 7380, year: 1999, vol: 283, page: 357, stat: Journal Article,

Role of the nuclear hormone receptor ROR gamma in transcriptional regulation, thymocyte survival, and lymphoid organogenesis
Littman DR; Sun Z; Unutmaz D; Sunshine MJ; Petrie HT; Zou YR
1999 ;64(3):373-381, Cold Spring Harbor symposia on quantitative biology
— id: 39445, year: 1999, vol: 64, page: 373, stat: Journal Article,

Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage
Morner A; Bjorndal A; Albert J; Kewalramani VN; Littman DR; Inoue R; Thorstensson R; Fenyo EM; Bjorling E
1999 Mar;73(3):2343-2349, Journal of virology
— id: 57056, year: 1999, vol: 73, page: 2343, stat: Journal Article,

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
Schaeffer EM; Debnath J; Yap G; McVicar D; Liao XC; Littman DR; Sher A; Varmus HE; Lenardo MJ; Schwartzberg PL
1999 Apr 23;284(5414):638-641, Science
— id: 15116, year: 1999, vol: 284, page: 638, stat: Journal Article,

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice
Shelbourne PF; Killeen N; Hevner RF; Johnston HM; Tecott L; Lewandoski M; Ennis M; Ramirez L; Li Z; Iannicola C; Littman DR; Myers RM
1999 May;8(5):763-774, Human molecular genetics
— id: 15117, year: 1999, vol: 8, page: 763, stat: Journal Article,

Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes
Unutmaz D; KewalRamani VN; Marmon S; Littman DR
1999 Jun 7;189(11):1735-1746, Journal of experimental medicine
— id: 6133, year: 1999, vol: 189, page: 1735, stat: Journal Article,

Differential requirements for CD4 in TCR-ligand interactions
Vidal K; Daniel C; Hill M; Littman DR; Allen PM
1999 Nov 1;163(9):4811-4818, Journal of immunology
— id: 15115, year: 1999, vol: 163, page: 4811, stat: Journal Article,

A new classification for HIV-1
Berger EA; Doms RW; Fenyo EM; Korber BT; Littman DR; Moore JP; Sattentau QJ; Schuitemaker H; Sodroski J; Weiss RA
1998 Jan 15;391(6664):240-240, Nature
— id: 57407, year: 1998, vol: 391, page: 240, stat: Journal Article,

Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usage
Cecilia D; KewalRamani VN; O'Leary J; Volsky B; Nyambi P; Burda S; Xu S; Littman DR; Zolla-Pazner S
1998 Sep;72(9):6988-6996, Journal of virology
— id: 7527, year: 1998, vol: 72, page: 6988, stat: Journal Article,

Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
Ellmeier W; Sunshine MJ; Losos K; Littman DR
1998 Oct;9(4):485-496, Immunity
— id: 57144, year: 1998, vol: 9, page: 485, stat: Journal Article,

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
Garber ME; Wei P; KewalRamani VN; Mayall TP; Herrmann CH; Rice AP; Littman DR; Jones KA
1998 Nov 15;12(22):3512-3527, Genes & development
— id: 7572, year: 1998, vol: 12, page: 3512, stat: Journal Article,

The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins
Hill CM; Kwon D; Jones M; Davis CB; Marmon S; Daugherty BL; DeMartino JA; Springer MS; Unutmaz D; Littman DR
1998 Sep 1;248(2):357-371, Virology
— id: 7599, year: 1998, vol: 248, page: 357, stat: Journal Article,

The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development
Irie HY; Mong MS; Itano A; Crooks ME; Littman DR; Burakoff SJ; Robey E
1998 Jul 1;161(1):183-191, Journal of immunology
— id: 7614, year: 1998, vol: 161, page: 183, stat: Journal Article,

Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus
Langlois AJ; Desrosiers RC; Lewis MG; KewalRamani VN; Littman DR; Zhou JY; Manson K; Wyand MS; Bolognesi DP; Montefiori DC
1998 Aug;72(8):6950-6955, Journal of virology
— id: 57190, year: 1998, vol: 72, page: 6950, stat: Journal Article,

Chemokine receptors: keys to AIDS pathogenesis?
Littman DR
1998 May 29;93(5):677-680, Cell
— id: 12106, year: 1998, vol: 93, page: 677, stat: Journal Article,

Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32
Michael NL; Nelson JA; KewalRamani VN; Chang G; O'Brien SJ; Mascola JR; Volsky B; Louder M; White GC 2nd; Littman DR; Swanstrom R; O'Brien TR
1998 Jul;72(7):6040-6047, Journal of virology
— id: 57343, year: 1998, vol: 72, page: 6040, stat: Journal Article,

Regulation of IL-4 expression by activation of individual alleles
Riviere I; Sunshine MJ; Littman DR
1998 Aug;9(2):217-228, Immunity
— id: 57232, year: 1998, vol: 9, page: 217, stat: Journal Article,

Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage
Trkola A; Ketas T; Kewalramani VN; Endorf F; Binley JM; Katinger H; Robinson J; Littman DR; Moore JP
1998 Mar;72(3):1876-1885, Journal of virology
— id: 15118, year: 1998, vol: 72, page: 1876, stat: Journal Article,

Differences in chemokine coreceptor usage between genetic subtypes of HIV-1
Tscherning C; Alaeus A; Fredriksson R; Bjorndal A; Deng H; Littman DR; Fenyo EM; Albert J
1998 Feb 15;241(2):181-188, Virology
— id: 7978, year: 1998, vol: 241, page: 181, stat: Journal Article,

G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models
Unutmaz D; KewalRamani VN; Littman DR
1998 Jun;10(3):225-236, Seminars in immunology
— id: 7833, year: 1998, vol: 10, page: 225, stat: Journal Article,

Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro
Zhang YJ; Dragic T; Cao Y; Kostrikis L; Kwon DS; Littman DR; KewalRamani VN; Moore JP
1998 Nov;72(11):9337-9344, Journal of virology
— id: 57289, year: 1998, vol: 72, page: 9337, stat: Journal Article,

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou YR; Kottmann AH; Kuroda M; Taniuchi I; Littman DR
1998 Jun 11;393(6685):595-599, Nature
— id: 57298, year: 1998, vol: 393, page: 595, stat: Journal Article,

Antiviral immune responses in Itk-deficient mice
Bachmann MF; Littman DR; Liao XC
1997 Oct;71(10):7253-7257, Journal of virology
— id: 15121, year: 1997, vol: 71, page: 7253, stat: Journal Article,

Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype
Bjorndal A; Deng H; Jansson M; Fiore JR; Colognesi C; Karlsson A; Albert J; Scarlatti G; Littman DR; Fenyo EM
1997 Oct;71(10):7478-7487, Journal of virology
— id: 15120, year: 1997, vol: 71, page: 7478, stat: Journal Article,

Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
Davis CB; Dikic I; Unutmaz D; Hill CM; Arthos J; Siani MA; Thompson DA; Schlessinger J; Littman DR
1997 Nov 17;186(10):1793-1798, Journal of experimental medicine
— id: 12196, year: 1997, vol: 186, page: 1793, stat: Journal Article,

Expression cloning of new receptors used by simian and human immunodeficiency viruses
Deng HK; Unutmaz D; KewalRamani VN; Littman DR
1997 Jul 17;388(6639):296-300, Nature
— id: 56936, year: 1997, vol: 388, page: 296, stat: Journal Article,

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
Ellmeier W; Sunshine MJ; Losos K; Hatam F; Littman DR
1997 Oct;7(4):537-547, Immunity
— id: 12237, year: 1997, vol: 7, page: 537, stat: Journal Article,

Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor
Hill CM; Deng H; Unutmaz D; Kewalramani VN; Bastiani L; Gorny MK; Zolla-Pazner S; Littman DR
1997 Sep;71(9):6296-6304, Journal of virology
— id: 57413, year: 1997, vol: 71, page: 6296, stat: Journal Article,

Itk negatively regulates induction of T cell proliferation by CD28 costimulation
Liao XC; Fournier S; Killeen N; Weiss A; Allison JP; Littman DR
1997 Jul 21;186(2):221-228, Journal of experimental medicine
— id: 15123, year: 1997, vol: 186, page: 221, stat: Journal Article,

Itk and Fyn make independent contributions to T cell activation
Liao XC; Littman DR; Weiss A
1997 Dec 15;186(12):2069-2073, Journal of experimental medicine
— id: 7658, year: 1997, vol: 186, page: 2069, stat: Journal Article,

Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene
Ranga U; Woffendin C; Yang ZY; Xu L; Verma S; Littman DR; Nabel GJ
1997 Sep;71(9):7020-7029, Journal of virology
— id: 15122, year: 1997, vol: 71, page: 7020, stat: Journal Article,

In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
Scarlatti G; Tresoldi E; Bjorndal A; Fredriksson R; Colognesi C; Deng HK; Malnati MS; Plebani A; Siccardi AG; Littman DR; Fenyo EM; Lusso P
1997 Nov;3(11):1259-1265, Nature medicine
— id: 15119, year: 1997, vol: 3, page: 1259, stat: Journal Article,

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells
Teh SJ; Killeen N; Tarakhovsky A; Littman DR; Teh HS
1997 Feb 15;89(4):1308-1318, Blood
— id: 15124, year: 1997, vol: 89, page: 1308, stat: Journal Article,

Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing
Unutmaz D; Littman DR
1997 Mar 4;94(5):1615-1618, Proceedings of the National Academy of Sciences of the United States of America
— id: 12356, year: 1997, vol: 94, page: 1615, stat: Journal Article,

Identification of a major co-receptor for primary isolates of HIV-1
Deng H; Liu R; Ellmeier W; Choe S; Unutmaz D; Burkhart M; Di Marzio P; Marmon S; Sutton RE; Hill CM; Davis CB; Peiper SC; Schall TJ; Littman DR; Landau NR
1996 Jun 20;381(6584):661-666, Nature
— id: 57390, year: 1996, vol: 381, page: 661, stat: Journal Article,

Natural resistance to HIV?
Hill CM; Littman DR
1996 Aug 22;382(6593):668-669, Nature
— id: 57364, year: 1996, vol: 382, page: 668, stat: Journal Article,

The regulation and function of the CD4 coreceptor during T lymphocyte development
Killeen N; Littman DR
1996 ;205:89-106, Current topics in microbiology & immunology
— id: 15128, year: 1996, vol: 205, page: 89, stat: Journal Article,

The CD4 molecule. Roles in T lymphocytes and in HIV disease. Introduction
Littman DR
1996 ;205:v-x, Current topics in microbiology & immunology
— id: 15129, year: 1996, vol: 205, page: v, stat: Journal Article,

Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system
Sutton RE; Littman DR
1996 Oct;70(10):7322-7326, Journal of virology
— id: 15125, year: 1996, vol: 70, page: 7322, stat: Journal Article,

Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay
Weiss CD; Barnett SW; Cacalano N; Killeen N; Littman DR; White JM
1996 Mar;10(3):241-246, AIDS
— id: 15126, year: 1996, vol: 10, page: 241, stat: Journal Article,

Inhibition of thymocyte negative selection by T cell receptor antagonist peptides
Williams O; Tanaka Y; Bix M; Murdjeva M; Littman DR; Kioussis D
1996 Mar;26(3):532-538, European journal of immunology
— id: 15127, year: 1996, vol: 26, page: 532, stat: Journal Article,

The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4
Benkirane M; Schmid-Antomarchi H; Littman DR; Hirn M; Rossi B; Devaux C
1995 Nov;69(11):6904-6910, Journal of virology
— id: 15132, year: 1995, vol: 69, page: 6904, stat: Journal Article,

CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation
Crooks ME; Littman DR; Carter RH; Fearon DT; Weiss A; Stein PH
1995 Dec;15(12):6820-6828, Molecular & cellular biology
— id: 15131, year: 1995, vol: 15, page: 6820, stat: Journal Article,

Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression
Davis CB; Littman DR
1995 Dec;7(12):1977-1986, International immunology
— id: 12705, year: 1995, vol: 7, page: 1977, stat: Journal Article,

Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules
Golding H; Dimitrov DS; Manischewitz J; Broder CC; Robinson J; Fabian S; Littman DR; Lapham CK
1995 Oct;69(10):6140-6148, Journal of virology
— id: 15133, year: 1995, vol: 69, page: 6140, stat: Journal Article,

The function of the CD4 coreceptor in the development of T cells
Killeen N; Littman DR
1995 ;13(1):15-27, International reviews of immunology
— id: 15134, year: 1995, vol: 13, page: 15, stat: Journal Article,

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
Liao XC; Littman DR
1995 Dec;3(6):757-769, Immunity
— id: 15130, year: 1995, vol: 3, page: 757, stat: Journal Article,

The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation
Xu H; Littman DR
1995 Sep 7;766:99-116, Annals of the New York Academy of Sciences
— id: 57371, year: 1995, vol: 766, page: 99, stat: Journal Article,

A subset of CD4+ thymocytes selected by MHC class I molecules
Bendelac A; Killeen N; Littman DR; Schwartz RH
1994 Mar 25;263(5154):1774-1778, Science
— id: 15141, year: 1994, vol: 263, page: 1774, stat: Journal Article,

Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction
Chu K; Littman DR
1994 Sep 30;269(39):24095-24101, Journal of biological chemistry
— id: 15135, year: 1994, vol: 269, page: 24095, stat: Journal Article,

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain
Crooks ME; Littman DR
1994 Jul;1(4):277-285, Immunity
— id: 15137, year: 1994, vol: 1, page: 277, stat: Journal Article,

Thymocyte lineage commitment: is it instructed or stochastic?
Davis CB; Littman DR
1994 Apr;6(2):266-272, Current opinion in immunology
— id: 15139, year: 1994, vol: 6, page: 266, stat: Journal Article,

Lymphocyte development in genetically manipulated mice
Killeen N; Littman DR
1994 Apr;1(2):123-133, Therapeutic immunology
— id: 15140, year: 1994, vol: 1, page: 123, stat: Journal Article,

Immunodeficiency viruses. Not enough sans Nef
Littman DR
1994 Jul 1;4(7):618-620, Current biology. CB
— id: 15136, year: 1994, vol: 4, page: 618, stat: Journal Article,

Signal transduction during T cell development
Littman DR; Davis CB; Killeen N; Xu H
1994 ;365:63-71, Advances in experimental medicine & biology
— id: 15143, year: 1994, vol: 365, page: 63, stat: Journal Article,

CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi
Rajan TV; Nelson FK; Killeen N; Shultz LD; Yates JA; Bailis JM; Littman DR; Greiner DL
1994 Jun;78(4):352-360, Experimental parasitology
— id: 15138, year: 1994, vol: 78, page: 352, stat: Journal Article,

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
Sawada S; Scarborough JD; Killeen N; Littman DR
1994 Jun 17;77(6):917-929, Cell
— id: 57506, year: 1994, vol: 77, page: 917, stat: Journal Article,

Signal transduction by lymphocyte antigen receptors
Weiss A; Littman DR
1994 Jan 28;76(2):263-274, Cell
— id: 15142, year: 1994, vol: 76, page: 263, stat: Journal Article,

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes [see comments]
Davis CB; Killeen N; Crooks ME; Raulet D; Littman DR
1993 Apr 23;73(2):237-247, Cell
— id: 15151, year: 1993, vol: 73, page: 237, stat: Journal Article,

Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time
Golding H; Blumenthal R; Manischewitz J; Littman DR; Dimitrov DS
1993 Nov;67(11):6469-6475, Journal of virology
— id: 15144, year: 1993, vol: 67, page: 6469, stat: Journal Article,

CD4 function in thymocyte differentiation and T cell activation
Killeen N; Davis CB; Chu K; Crooks ME; Sawada S; Scarborough JD; Boyd KA; Stuart SG; Xu H; Littman DR
1993 Oct 29;342(1299):25-34, Philosophical transactions of the Royal Society of London. Series B. Biological sciences
— id: 15145, year: 1993, vol: 342, page: 25, stat: Journal Article,

Helper T-cell development in the absence of CD4-p56lck association
Killeen N; Littman DR
1993 Aug 19;364(6439):729-732, Nature
— id: 15149, year: 1993, vol: 364, page: 729, stat: Journal Article,

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
Killeen N; Sawada S; Littman DR
1993 Apr;12(4):1547-1553, EMBO journal
— id: 15152, year: 1993, vol: 12, page: 1547, stat: Journal Article,

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice
Locksley RM; Reiner SL; Hatam F; Littman DR; Killeen N
1993 Sep 10;261(5127):1448-1451, Science
— id: 15146, year: 1993, vol: 261, page: 1448, stat: Journal Article,

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
Sawada S; Littman DR
1993 Sep;13(9):5620-5628, Molecular & cellular biology
— id: 15147, year: 1993, vol: 13, page: 5620, stat: Journal Article,

A kinase-independent function of Lck in potentiating antigen-specific T cell activation
Xu H; Littman DR
1993 Aug 27;74(4):633-643, Cell
— id: 15148, year: 1993, vol: 74, page: 633, stat: Journal Article,

Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein increases env incorporation into particles and fusogenicity and infectivity
Zingler K; Littman DR
1993 May;67(5):2824-2831, Journal of virology
— id: 15150, year: 1993, vol: 67, page: 2824, stat: Journal Article,

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells
Killeen N; Moriarty A; Teh HS; Littman DR
1992 Jul 1;176(1):89-97, Journal of experimental medicine
— id: 15155, year: 1992, vol: 176, page: 89, stat: Journal Article,

Development and function of T cells in mice with a disrupted CD2 gene
Killeen N; Stuart SG; Littman DR
1992 Dec;11(12):4329-4336, EMBO journal
— id: 15153, year: 1992, vol: 11, page: 4329, stat: Journal Article,

Packaging system for rapid production of murine leukemia virus vectors with variable tropism
Landau NR; Littman DR
1992 Aug;66(8):5110-5113, Journal of virology
— id: 15154, year: 1992, vol: 66, page: 5110, stat: Journal Article,

Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity
Page KA; Stearns SM; Littman DR
1992 Jan;66(1):524-533, Journal of virology
— id: 15158, year: 1992, vol: 66, page: 524, stat: Journal Article,

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits
Pelchen-Matthews A; Boulet I; Littman DR; Fagard R; Marsh M
1992 Apr;117(2):279-290, Journal of cell biology
— id: 15156, year: 1992, vol: 117, page: 279, stat: Journal Article,

Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development
van Oers NS; Garvin AM; Cooke MP; Davis CB; Littman DR; Perlmutter RM; Teh HS
1992 ;323:89-99, Advances in experimental medicine & biology
— id: 15159, year: 1992, vol: 323, page: 89, stat: Journal Article,

Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck
Van Oers NS; Garvin AM; Davis CB; Forbush KA; Carlow DA; Littman DR; Perlmutter RM; Teh HS
1992 Mar;22(3):735-743, European journal of immunology
— id: 15157, year: 1992, vol: 22, page: 735, stat: Journal Article,

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells
Glaichenhaus N; Shastri N; Littman DR; Turner JM
1991 Feb 8;64(3):511-520, Cell
— id: 15164, year: 1991, vol: 64, page: 511, stat: Journal Article,

Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides
Jasin M; Page KA; Littman DR
1991 Jan;65(1):440-444, Journal of virology
— id: 15167, year: 1991, vol: 65, page: 440, stat: Journal Article,

Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range
Landau NR; Page KA; Littman DR
1991 Jan;65(1):162-169, Journal of virology
— id: 15166, year: 1991, vol: 65, page: 162, stat: Journal Article,

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias
Muller AJ; Young JC; Pendergast AM; Pondel M; Landau NR; Littman DR; Witte ON
1991 Apr;11(4):1785-1792, Molecular & cellular biology
— id: 15163, year: 1991, vol: 11, page: 1785, stat: Journal Article,

Several CD4 domains can play a role in human immunodeficiency virus infection in cells
Poulin L; Evans LA; Tang SB; Barboza A; Legg H; Littman DR; Levy JA
1991 Sep;65(9):4893-4901, Journal of virology
— id: 15162, year: 1991, vol: 65, page: 4893, stat: Journal Article,

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene
Sawada S; Littman DR
1991 Nov;11(11):5506-5515, Molecular & cellular biology
— id: 15160, year: 1991, vol: 11, page: 5506, stat: Journal Article,

Participation of CD4 coreceptor molecules in T-cell repertoire selection
Teh HS; Garvin AM; Forbush KA; Carlow DA; Davis CB; Littman DR; Perlmutter RM
1991 Jan 17;349(6306):241-243, Nature
— id: 15165, year: 1991, vol: 349, page: 241, stat: Journal Article,

The thymus leukemia antigen binds human and mouse CD8
Teitell M; Mescher MF; Olson CA; Littman DR; Kronenberg M
1991 Nov 1;174(5):1131-1138, Journal of experimental medicine
— id: 15161, year: 1991, vol: 174, page: 1131, stat: Journal Article,

Analysis of the site in CD4 that binds to the HIV envelope glycoprotein
Brodsky MH; Warton M; Myers RM; Littman DR
1990 Apr 15;144(8):3078-3086, Journal of immunology
— id: 15170, year: 1990, vol: 144, page: 3078, stat: Journal Article,

Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity
Page KA; Landau NR; Littman DR
1990 Nov;64(11):5270-5276, Journal of virology
— id: 15168, year: 1990, vol: 64, page: 5270, stat: Journal Article,

A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2
Salter RD; Benjamin RJ; Wesley PK; Buxton SE; Garrett TP; Clayberger C; Krensky AM; Norment AM; Littman DR; Parham P
1990 May 3;345(6270):41-46, Nature
— id: 15169, year: 1990, vol: 345, page: 41, stat: Journal Article,

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
Turner JM; Brodsky MH; Irving BA; Levin SD; Perlmutter RM; Littman DR
1990 Mar 9;60(5):755-765, Cell
— id: 15171, year: 1990, vol: 60, page: 755, stat: Journal Article,

Role of cell-to-cell interactions in T lymphocyte development and activation
Littman DR
1989 Oct;1(5):920-928, Current opinion in cell biology
— id: 15172, year: 1989, vol: 1, page: 920, stat: Journal Article,

Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene
Norment AM; Lonberg N; Lacy E; Littman DR
1989 May 1;142(9):3312-3319, Journal of immunology
— id: 15173, year: 1989, vol: 142, page: 3312, stat: Journal Article,

Diversity of class I HLA molecules: functional and evolutionary interactions with T cells
Parham P; Benjamin RJ; Chen BP; Clayberger C; Ennis PD; Krensky AM; Lawlor DA; Littman DR; Norment AM; Orr HT; et al
1989 ;54 Pt 1:529-543, Cold Spring Harbor symposia on quantitative biology
— id: 15176, year: 1989, vol: 54 Pt 1, page: 529, stat: Journal Article,

Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8
Salter RD; Norment AM; Chen BP; Clayberger C; Krensky AM; Littman DR; Parham P
1989 Mar 23;338(6213):345-347, Nature
— id: 15174, year: 1989, vol: 338, page: 345, stat: Journal Article,

Viral receptors of the immunoglobulin superfamily
White JM; Littman DR
1989 Mar 10;56(5):725-728, Cell
— id: 15175, year: 1989, vol: 56, page: 725, stat: Journal Article,

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4
Bedinger P; Moriarty A; von Borstel RC 2d; Donovan NJ; Steimer KS; Littman DR
1988 Jul 14;334(6178):162-165, Nature
— id: 15181, year: 1988, vol: 334, page: 162, stat: Journal Article,

Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression
Kaldjian E; McCarthy SA; Sharrow SO; Littman DR; Klausner RD; Singer A
1988 Sep;2(12):2801-2806, FASEB journal
— id: 15180, year: 1988, vol: 2, page: 2801, stat: Journal Article,

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4
Landau NR; Warton M; Littman DR
1988 Jul 14;334(6178):159-162, Nature
— id: 57528, year: 1988, vol: 334, page: 159, stat: Journal Article,

Corrected CD4 sequence
Littman DR; Maddon PJ; Axel R
1988 Nov 18;55(4):541-541, Cell
— id: 15177, year: 1988, vol: 55, page: 541, stat: Journal Article,

Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein
Lonberg N; Gettner SN; Lacy E; Littman DR
1988 May;8(5):2224-2228, Molecular & cellular biology
— id: 15182, year: 1988, vol: 8, page: 2224, stat: Journal Article,

Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes
Newgard CB; Littman DR; van Genderen C; Smith M; Fletterick RJ
1988 Mar 15;263(8):3850-3857, Journal of biological chemistry
— id: 15183, year: 1988, vol: 263, page: 3850, stat: Journal Article,

A second subunit of CD8 is expressed in human T cells
Norment AM; Littman DR
1988 Nov;7(11):3433-3439, EMBO journal
— id: 15179, year: 1988, vol: 7, page: 3433, stat: Journal Article,

Cell-cell adhesion mediated by CD8 and MHC class I molecules
Norment AM; Salter RD; Parham P; Engelhard VH; Littman DR
1988 Nov 3;336(6194):79-81, Nature
— id: 15178, year: 1988, vol: 336, page: 79, stat: Journal Article,

Patterns of T cell receptor gamma gene rearrangement and expression in B and T lymphoid malignancies
Subar M; Giuseppe Pelicci P; Neri A; Allavena P; Littman DR; Knowles DM 2d; Dalla-Favera R
1988 Jan;2(1):19-26, Leukemia
— id: 11261, year: 1988, vol: 2, page: 19, stat: Journal Article,

The structure of the CD4 and CD8 genes
Littman DR
1987 ;5:561-584, Annual review of immunology
— id: 15188, year: 1987, vol: 5, page: 561, stat: Journal Article,

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene
Littman DR; Gettner SN
1987 Jan 29-Feb 4;325(6103):453-455, Nature
— id: 15187, year: 1987, vol: 325, page: 453, stat: Journal Article,

Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism
Littman DR; Newton M; Crommie D; Ang SL; Seidman JG; Gettner SN; Weiss A
1987 Mar 5-11;326(6108):85-88, Nature
— id: 15186, year: 1987, vol: 326, page: 85, stat: Journal Article,

Identification and sequence of a fourth human T cell antigen receptor chain
Loh EY; Lanier LL; Turck CW; Littman DR; Davis MM; Chien YH; Weiss A
1987 Dec 10-16;330(6148):569-572, Nature
— id: 15184, year: 1987, vol: 330, page: 569, stat: Journal Article,

Arrangements and rearrangements of the human T-cell receptor gamma gene
Pelicci PG; Neri A; Knowles DM 2d; Littman DR; Dalla-Favera R; Subar M
1987 ;511:232-245, Annals of the New York Academy of Sciences
— id: 11425, year: 1987, vol: 511, page: 232, stat: Journal Article,

Molecular diversity of the human T-gamma constant region genes
Pelicci PG; Subar M; Weiss A; Dalla-Favera R; Littman DR
1987 Aug 28;237(4818):1051-1055, Science
— id: 15185, year: 1987, vol: 237, page: 1051, stat: Journal Article,

The gene encoding the T-cell surface protein T4 is located on human chromosome 12
Isobe M; Huebner K; Maddon PJ; Littman DR; Axel R; Croce CM
1986 Jun;83(12):4399-4402, Proceedings of the National Academy of Sciences of the United States of America
— id: 15189, year: 1986, vol: 83, page: 4399, stat: Journal Article,

The T4 glycoprotein is a cell-surface receptor for the AIDS virus
McDougal JS; Maddon PJ; Dalgleish AG; Clapham PR; Littman DR; Godfrey M; Maddon DE; Chess L; Weiss RA; Axel R
1986 ;51 Pt 2:703-711, Cold Spring Harbor symposia on quantitative biology
— id: 15190, year: 1986, vol: 51 Pt 2, page: 703, stat: Journal Article,

The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes
Littman DR; Thomas Y; Maddon PJ; Chess L; Axel R
1985 Feb;40(2):237-246, Cell
— id: 15192, year: 1985, vol: 40, page: 237, stat: Journal Article,

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family
Maddon PJ; Littman DR; Godfrey M; Maddon DE; Chess L; Axel R
1985 Aug;42(1):93-104, Cell
— id: 15191, year: 1985, vol: 42, page: 93, stat: Journal Article,

Structural comparison of murine Ia antigens determined by the I-A and I-E subregions
Cullen SE; Kindle CS; Littman DR
1979 Mar;122(3):855-859, Journal of immunology
— id: 15193, year: 1979, vol: 122, page: 855, stat: Journal Article,

Insertion of Ia and H-2 alloantigens into model membranes
Littman DR; Cullen SE; Schwartz BD
1979 Feb;76(2):902-906, Proceedings of the National Academy of Sciences of the United States of America
— id: 15194, year: 1979, vol: 76, page: 902, stat: Journal Article,

Properties of the depolymerization products of microtubules from mammalian brain
Weingarten MD; Suter MM; Littman DR; Kirschner MW
1974 Dec 31;13(27):5529-5537, Biochemistry
— id: 15195, year: 1974, vol: 13, page: 5529, stat: Journal Article,