Richard I. Levin

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Richard Levin

Adjunct Professor, Department of Medicine;Professor Emeritus of Medicine, Department of Medicine

Contact Info



1974 — NYU, Medical Education
1974-1975 — NYU Medical Center (Medicine), Internship
1975-1978 — NYU Medical Center (Medicine), Residency Training
1978-1980 — NYU Medical Center (Cardiology), Clinical Fellowships

Research Summary

The NYU School of Medicine's Laboratory for Cardiovascular Research in the Department of Medicine uses a multidisciplinary approach to study atherosclerosis from bench to bedside. We focus on the effects of atherogenic biomolecules which modify endothelial function in leukocyte-endothelial interaction, thombosis and fibrinolysis, and endothelial proliferation.

The most compelling theory on the origins of atherosclerosis proposes that atherosclerosis is secondary to endothelial dysfunction or denuding endothelial injury. The mass of atherosclerosis, in turn, is proportional to both the magnitude and persistence of endothelial injury such that factors which delay reendothelialization enhance atherosclerosis. While atherosclerosis accelerates in patients with chronic renal failure (CRF) who are maintained on dialysis, the causes for this acceleration are unknown. We discovered that uremic levels of the end-metabolite oxalic acid dramatically inhibit the proliferation and migration of human endothelial cells (EC) in vitro. Oxalate inhibits endothelial regeneration and is, therefore, a candidate atherogenic toxin. Our recent work links these phenomena to an elevation in intracellular calcium [Ca++]i unique to EC. While it is clear that [Ca++]i is modulated during the cell cycle, it is not clear whether this modulation is both necessary and sufficient for progression through the cell cycle. Thus, the role of [Ca++]i as an oxalate-dependent moderator of EC proliferation is unknown. We are exploring the precise molecular mechanisms by which oxalate increases [Ca++]i, thereby inhibiting reedothelialization and promoting atherogenesis.

Research Interests

Endothelial Modulation of Atherosclerosis

Gazing through the crystal ball of science-cardiovascular disease in 2100
Fishman, G I; Levin, R I
2013-04-15; 1758-3896,US cardiology - id: 287912, year: 2012

Publishing in the age of the digital doctor
Levin, R I
2012-02-05; 1198-0052,Current oncology (Toronto, Ont.) - id: 124100, year: 2011

The power of Pasteur's quadrant: cardiovascular disease at the turn of the century
Levin, Richard I; Fishman, Glenn I
2012-02-05; 1530-6860,FASEB journal - id: 134174, year: 2011

Internal medicine residency training in the 21st century: aligning requirements with professional needs
Charap, Mitchell H; Levin, Richard I; Pearlman, R Ellen; Blaser, Martin J
2012-02-05; 0002-9343,American journal of medicine - id: 58700, year: 2005 Journal Article

The puzzle of aspirin and sex
Levin, RI
2012-02-05; 0028-4793,New England journal of medicine - id: 50417, year: 2005