Lung-Chi Chen

Biosketch / Results /

Lung-Chi Chen

Professor, Department of Environmental Medicine
Environmental Medicine

Contact Info

57 Old Forge Rd.
Tuxedo, NY 10987



1983 — Dr. Lung Chi Chen received his Ph.D. in Environmental Health Science from New York University, NY, NY, Graduate Education
— NYU, Medical Education

Research Summary

Dr. Chen is an internationally recognized expert on inhalation toxicology and has extensive experience in the measurement of cardiopulmonary effects of inhaled pollutants. He is also an expert in the generation and characterization of exposure atmospheres, and in the performance of toxicology studies using all routes of exposure, primarily those involving pulmonary exposure. He has served on a number of national and international committees and study sections in his areas of expertise. Dr. Chen is the author of over 120 research papers and book chapters dealing with the mechanisms underlying the adverse cardiopulmonary effects resulting from inhalation exposure to occupational and environmental air pollutants. His research approach is to systematically dissect the role that physico-chemical properties of these pollutants play in the exposure, uptake at sites of deposition in the respiratory tract and translocation to the heart, as well as in the development, progression, and resolution of cardiopulmonary diseases.

Research Interests

1. Nanoparticle Toxicity and functional utilization. 2. The role of health disparity in air pollution-induced cardiopulmonary diseases 3. Gene-environment interactions in environmentally induced diseases 4. Effects of particulate air pollution in the pathogenesis of atherosclerosis 5. Mechanisms of air pollution induced asthma 6. Pollutant-induced alterations in biological response modifiers and associated membrane receptors 7. Signal transduction pathways associated with oxidative stress

Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures
Chen, Lung-Chi; Lippmann, Morton
2015-02-08; 1934-9254,Current protocols in toxicology - id: 1456442, year: 2015 Journal Article

Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung
Cohen, Mitchell D; Vaughan, Joshua M; Garrett, Brittany; Prophete, Colette; Horton, Lori; Sisco, Maureen; Kodavanti, Urmila P; Ward, William O; Peltier, Richard E; Zelikoff, Judith; Chen, Lung-Chi
2015-02-16; 1547-691x,Journal of immunotoxicology - id: 1462842, year: 2015 Journal Article

Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract
Asgharian, B; Price, O T; Oldham, M; Chen, Lung-Chi; Saunders, E L; Gordon, T; Mikheev, V B; Minard, K R; Teeguarden, J G
2015-01-07; 0895-8378,Inhalation toxicology - id: 1423642, year: 2014 Journal Article

Particulate matter from saudi arabia induces genes involved in inflammation, metabolic syndrome and atherosclerosis
Brocato, Jason; Sun, Hong; Shamy, Magdy; Kluz, Thomas; Alghamdi, Mansour A; Khoder, Mamdouh I; Chen, Lung-Chi; Costa, Max
2014-05-26; 0098-4108,Journal of toxicology & environmental health - id: 1004972, year: 2014 Journal Article

CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure
Rao, Xiaoquan; Zhong, Jixin; Maiseyeu, Andrei; Gopalakrishnan, Bhavani; Villamena, Frederick A; Chen, Lung-Chi; Harkema, Jack R; Sun, Qinghua; Rajagopalan, Sanjay
2014-10-20; 0009-7330,Circulation research - id: 1310822, year: 2014 Journal Article