Lung-Chi Chen

Biosketch / Results /

Lung-Chi Chen

Professor, Department of Environmental Medicine

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845/731-3560
Lung-Chi.Chen@nyumc.org


Education

— NYU, Medical Education

Research Summary

Dr. Chen is an internationally recognized expert on inhalation toxicology and has extensive experience in the measurement of cardiopulmonary effects of inhaled pollutants. He is also an expert in the generation and characterization of exposure atmospheres, and in the performance of toxicology studies using all routes of exposure, primarily those involving pulmonary exposure. He has served on a number of national and international committees and study sections in his areas of expertise. Dr. Chen is the author of over 120 research papers and book chapters dealing with the mechanisms underlying the adverse cardiopulmonary effects resulting from inhalation exposure to occupational and environmental air pollutants. His research approach is to systematically dissect the role that physico-chemical properties of these pollutants play in the exposure, uptake at sites of deposition in the respiratory tract and translocation to the heart, as well as in the development, progression, and resolution of cardiopulmonary diseases.

Research Interests

1. Nanoparticle Toxicity and functional utilization. 2. The role of health disparity in air pollution-induced cardiopulmonary diseases 3. Gene-environment interactions in environmentally induced diseases 4. Effects of particulate air pollution in the pathogenesis of atherosclerosis 5. Mechanisms of air pollution induced asthma 6. Pollutant-induced alterations in biological response modifiers and associated membrane receptors 7. Signal transduction pathways associated with oxidative stress

Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung
Anderson, Donald S; Patchin, Esther S; Silva, Rona M; Uyeminami, Dale L; Sharmah, Arjun; Guo, Ting; Das, Gautom K; Brown, Jared M; Shannahan, Jonathan; Gordon, Terry; Chen, Lung Chi; Pinkerton, Kent E; Van Winkle, Laura S. Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. Toxicological sciences. 2015 Jan 9;144(2):366-381 (1520502)

In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes
Brocato, Jason; Hernandez, Michelle; Laulicht, Freda; Sun, Hong; Shamy, Magdy; Alghamdi, Mansour A; Khoder, Mamdouh I; Kluz, Thomas; Chen, Lung-Chi; Costa, Max. In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes. Journal of toxicology & environmental health. Pt. A. 2015 ;78(23-24):1421-1436 (1883922)

INCITING RAGE: WORLD TRADE CENTER LUNG INJURY AND THERAPY IN A MURINE MODEL
Caraher, Erin; Kwon, Sophia; Lee, Audrey K; Echevarria, Ghislaine C; Chen, Lung-Chi; Gordon, Terry; Prezant, David J; Rom, William N; Schmidt, Ann M; Weiden, Michael D; Nolan, Anna. INCITING RAGE: WORLD TRADE CENTER LUNG INJURY AND THERAPY IN A MURINE MODEL [Meeting Abstract]. Clinical & translational science. 2015 June;8(3):249-249 (1810302)

Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures
Chen, Lung-Chi; Lippmann, Morton. Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures. Current protocols in toxicology. 2015 Feb 2;63:24.4.1-24.423 (1456442)

Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung
Cohen, Mitchell D; Vaughan, Joshua M; Garrett, Brittany; Prophete, Colette; Horton, Lori; Sisco, Maureen; Kodavanti, Urmila P; Ward, William O; Peltier, Richard E; Zelikoff, Judith; Chen, Lung-Chi. Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung. Journal of immunotoxicology. 2015 Apr -0;12(2):140-153 (1462842)