Lung-Chi Chen

Biosketch / Results /

Lung-Chi Chen

Professor, Department of Environmental Medicine

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845-731-3560
Lung-Chi.Chen@nyumc.org


Education

— NYU, Medical Education

Research Summary

Dr. Chen is an internationally recognized expert on inhalation toxicology and has extensive experience in the measurement of cardiopulmonary effects of inhaled pollutants. He is also an expert in the generation and characterization of exposure atmospheres, and in the performance of toxicology studies using all routes of exposure, primarily those involving pulmonary exposure. He has served on a number of national and international committees and study sections in his areas of expertise. Dr. Chen is the author of over 120 research papers and book chapters dealing with the mechanisms underlying the adverse cardiopulmonary effects resulting from inhalation exposure to occupational and environmental air pollutants. His research approach is to systematically dissect the role that physico-chemical properties of these pollutants play in the exposure, uptake at sites of deposition in the respiratory tract and translocation to the heart, as well as in the development, progression, and resolution of cardiopulmonary diseases.

Research Keywords

nanoparticle toxicity and functional utilization, role of health disparity in air pollution-induced cardiopulmonary diseases, gene-environment interactions in environmentally induced diseases, effects of particulate air pollution in the pathogenesis of atherosclerosis, mechanisms of air pollution induced asthma, pollutant-induced alterations in biological response modifiers and associated membrane receptors, signal transduction pathways associated with oxidative stress

Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila
Wang, Xiaoke; Chen, Minjie; Zhong, Mianhua; Hu, Ziying; Qiu, Lianglin; Rajagopalan, Sanjay; Fossett, Nancy G; Chen, Lung-Chi; Ying, Zhekang. Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila. Toxicological sciences. 2017 Jan 9;:?-? (2424822)

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells
Huang, Haishan; Zhu, Junlan; Li, Yang; Zhang, Liping; Gu, Jiayan; Xie, Qipeng; Jin, Honglei; Che, Xun; Li, Jingxia; Huang, Chao; Chen, Lung-Chi; Lyu, Jianxin; Gao, Jimin; Huang, Chuanshu. Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Autophagy. 2016 Oct 02;12(10):1687-1703 (2191672)

Improving Knowledge about Children's Environmental Health in Northwest China
Niu, Jingping; Qu, Qingshan; Li, Juansheng; Liu, Xingrong; Zhang, Benzhong; Li, Zhilan; Ding, Guowu; Sun, Yingbiao; Shi, Yanrong; Wan, Yaxiong; Hu, Xiaobin; Chen, Lung-Chi; Mendelsohn, Alan; Chen, Yu; Trasande, Leonardo. Improving Knowledge about Children's Environmental Health in Northwest China. International journal of environmental research & public health. 2015 Dec 25;13(1):80-80 (1894472)

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation
Lee, Hyun-Wook; Wang, Hsiang-Tsui; Weng, Mao-Wen; Chin, Chiu; Huang, William; Lepor, Herbert; Wu, Xue-Ru; Rom, William N; Chen, Lung-Chi; Tang, Moon-Shong. Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation. Oncotarget. 2015 Oct 20;6(32):33226-33236 (1790072)

Malignant human cell transformation of Marcellus Shale gas drilling flow back water
Yao, Yixin; Chen, Tingting; Shen, Steven S; Niu, Yingmei; DesMarais, Thomas L; Linn, Reka; Saunders, Eric; Fan, Zhihua; Lioy, Paul; Kluz, Thomas; Chen, Lung-Chi; Wu, Zhuangchun; Costa, Max. Malignant human cell transformation of Marcellus Shale gas drilling flow back water. Toxicology & applied pharmacology. 2015 Oct 01;288(1):121-130 (1698402)