Nathaniel R. Landau

Biosketch / Results /

Nathaniel Landau

Professor, Department of Microbiology

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-9197
Nathaniel.Landau@med.nyu.edu

Education

1986 — MIT, Medical Education

Research Summary

Mammalian cells resist virus infections through the collection of mechanisms termed innate or intrinsic immunity. One such mechanism consists of a family of cytidine deaminases termed APOBEC3. These enzymes serve as mutators that destroy the genetic material of viruses such as HIV. HIV encodes a protein of its own, termed virion infectivity factor (Vif), that binds to APOBEC3 causing its degradation. We have focused on the mechanism by which APOBEC3 and Vif function and the species specificity of the interaction. We are also developing methods to identify small molecule inhibitors that disrupt the interaction. HIV encodes a second protein, viral protein R (VPR), that is involved in inducing the degradation of several host cell proteins and that may be a second means by which HIV counteracts intrinsic immunity. Vpr binds to a chromatin-associated E3 ubiquitin ligase consisting of DDB1/CUL4A/ROC1 through the DDB1 Cullin associated factor 1 (DCAF1). The complex degrades several host proteins. We are investigating the role of this complex in HIV replication and pathogenesis and how the Vpr controls affects its function.

Research Keywords

HIV virion infectivity factor (VIF), HIV viral protein R (VPR), HIV accessory proteins, resistance to HIV infection, immunology, microbiology

Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5
Tam, Kayan; Schultz, Megan; Reyes-Robles, Tamara; Vanwalscappel, Benedicte; Horton, Joshua; Alonzo, Francis 3rd; Wu, Beili; Landau, Nathaniel R; Torres, Victor J. Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5. MBio. 2016 Dec 13;7(6):?-? (2363422)

IFN-epsilon protects primary macrophages against HIV infection
Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L. IFN-epsilon protects primary macrophages against HIV infection. JCI insight. 2016 Dec 8;1(20):e88255-e88255 e88255 (2363312)

A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse
Bloch, Nicolin; Glasker, Sabine; Sitaram, Poojitha; Hofmann, Henning; Shepard, Caitlin N; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R. A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse. Journal of biological chemistry. 2016 Dec 5;:?-? (2354272)

TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes
Hofmann, Henning; Vanwalscappel, Benedicte; Bloch, Nicolin; Landau, Nathaniel R. TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes. Retrovirology. 2016 Dec 01;13(1):83-83 (2328112)

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape
Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R. Intrinsic host restrictions to HIV-1 and mechanisms of viral escape. Nature immunology. 2015 Jun;16(6):546-553 (1620312)