Nathaniel R. Landau

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Nathaniel R. Landau, D.Phil., Ph.D.

Department of Microbiology (Microbiology )

Contact Info

522 First Avenue
Dept of Microbiology Floor 10 Room 1003
Smilow Research Building
New York, NY 10016


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— Dr. Landau was a Postdoctoral Associate at MIT in 1986. He was a Fellow of the Cancer Research Institute at the University of California, San Francisco from 1987-1991, PostDoctoral Training
1986 — MIT, Medical Education
1986 — MIT, Graduate Education

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Research Summary

Mammalian cells resist virus infections through the collection of mechanisms termed innate or intrinsic immunity. One such mechanism consists of a family of cytidine deaminases termed APOBEC3. These enzymes serve as mutators that destroy the genetic material of viruses such as HIV. HIV encodes a protein of its own, termed virion infectivity factor (Vif), that binds to APOBEC3 causing its degradation. We have focused on the mechanism by which APOBEC3 and Vif function and the species specificity of the interaction. We are also developing methods to identify small molecule inhibitors that disrupt the interaction. HIV encodes a second protein, viral protein R (VPR), that is involved in inducing the degradation of several host cell proteins and that may be a second means by which HIV counteracts intrinsic immunity. Vpr binds to a chromatin-associated E3 ubiquitin ligase consisting of DDB1/CUL4A/ROC1 through the DDB1 Cullin associated factor 1 (DCAF1). The complex degrades several host proteins. We are investigating the role of this complex in HIV replication and pathogenesis and how the Vpr controls affects its function.

Research Interests

HIV virion infectivity factor (VIF) HIV viral protein R (VPR) HIV accessory proteins resistance to HIV infection

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All data from NYU Health Sciences Library Faculty Bibliography — -


Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest
Hakata, Yoshiyuki; Miyazawa, Masaaki; Landau, Nathaniel R
2014 ;11(1):108-108, Virology journal
— id: 1042312, year: 2014, vol: 11, page: 108, stat: Journal Article,

Inhibition of Cul4A Neddylation Causes a Reversible Block To SAMHD1-Mediated Restriction of HIV-1
Hofmann, H; Norton, T D; Logue, E C; Schultz, M L; Polsky, S B; Sunseri, N; Landau, N R
2014 Apr 2014;(568(pages22):25-25, Topics in antiviral medicine
— id: 1291982, year: 2014, vol: (568, page: 25, stat: Journal Article,

SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors
Huber, Andrew D; Michailidis, Eleftherios; Schultz, Megan L; Ong, Yee T; Bloch, Nicolin; Puray-Chavez, Maritza N; Leslie, Maxwell D; Ji, Juan; Lucas, Anthony D; Kirby, Karen A; Landau, Nathaniel R; Sarafianos, Stefan G
2014 Aug;58(8):4915-4919, Antimicrobial agents & chemotherapy
— id: 1153732, year: 2014, vol: 58, page: 4915, stat: Journal Article,

The Innate Immune Response to HIV-1: To Sense or Not to Sense
Landau, Nathaniel R
2014 May;33(5):271-274, DNA & cell biology
— id: 970082, year: 2014, vol: 33, page: 271, stat: Journal Article,

A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity
Logue, Eric C; Bloch, Nicolin; Dhuey, Erica; Zhang, Ruonan; Cao, Ping; Herate, Cecile; Chauveau, Lise; Hubbard, Stevan R; Landau, Nathaniel R
2014 ;9(5):e97062-e97062 e97062, PLoS one
— id: 996992, year: 2014, vol: 9, page: e97062, stat: Journal Article,

Attenuated Listeria monocytogenes Vectors Overcome Suppressive Plasma Factors during HIV Infection to Stimulate Myeloid Dendritic Cells to Promote Adaptive Immunity and Reactivation of Latent Virus
Miller, Elizabeth; Spadaccia, Meredith; Norton, Thomas David; Demmler, Morgan; Gopal, Ramya; O'Brien, Meagan; Landau, Nathaniel R; Dubensky, Thomas; Lauer, Peter; Brockstedt, Dirk; Bhardwaj, Nina
2014 Nov;:?-?, AIDS research & human retroviruses
— id: 1349952, year: 2014, vol: , page: ?, stat: Journal Article,

Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3
Minkah, Nana; Chavez, Kevin; Shah, Parth; Maccarthy, Thomas; Chen, Hui; Landau, Nathaniel; Krug, Laurie T
2014 Apr;454-455:215-226, Virology
— id: 882002, year: 2014, vol: 454-455, page: 215, stat: Journal Article,

SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells
Zhang, Ruonan; Bloch, Nicolin; Nguyen, Laura A; Kim, Baek; Landau, Nathaniel R
2014 ;9(2):e89558-e89558 e89558, PLoS one
— id: 829622, year: 2014, vol: 9, page: e89558, stat: Journal Article,

CCR5 is a receptor for Staphylococcus aureus leukotoxin ED
Alonzo, Francis 3rd; Kozhaya, Lina; Rawlings, Stephen A; Reyes-Robles, Tamara; DuMont, Ashley L; Myszka, David G; Landau, Nathaniel R; Unutmaz, Derya; Torres, Victor J
2013 Jan;493(7430):51-55, Nature
— id: 211102, year: 2013, vol: 493, page: 51, stat: Journal Article,

HIV Type 1 Infection of Plasmacytoid and Myeloid Dendritic Cells Is Restricted by High Levels of SAMHD1 and Cannot be Counteracted by Vpx
Bloch, Nicolin; O'Brien, Meagan; Norton, Thomas D; Polsky, Sylvie B; Bhardwaj, Nina; Landau, Nathaniel R
2013 Sep;:195-203, AIDS research & human retroviruses
— id: 674952, year: 2013, vol: , page: 195, stat: Journal Article,

Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein
Bobadilla, S; Sunseri, N; Landau, N R
2013 May;20(5):514-520, Gene therapy
— id: 335432, year: 2013, vol: 20, page: 514, stat: Journal Article,

Restriction of diverse retroviruses by SAMHD1
Gramberg, Thomas; Kahle, Tanja; Bloch, Nicolin; Wittmann, Sabine; Mullers, Erik; Daddacha, Waaqo; Hofmann, Henning; Kim, Baek; Lindemann, Dirk; Landau, Nathaniel R
2013 ;10:26-26, Retrovirology
— id: 248242, year: 2013, vol: 10, page: 26, stat: Journal Article,

Inhibition of CUL4A Neddylation Causes a Reversible Block to SAMHD1-Mediated Restriction of HIV-1
Hofmann, Henning; Norton, Thomas D; Schultz, Megan L; Polsky, Sylvie B; Sunseri, Nicole; Landau, Nathaniel R
2013 Nov;87(21):11741-11750, Journal of virology
— id: 573852, year: 2013, vol: 87, page: 11741, stat: Journal Article,

Vpx improves nuclear import and uncovers a restriction to lentiviral integration in quiescent human hematopoietic stem and progenitor cells
Petrillo, C.; Piras, F.; Bartolaccini, S.; Landau, N. R.; Naldini, L.; Kajaste-Rudnitski, A.
2013 DEC 1;24(12):A73-A73, Human gene therapy
— id: 781392, year: 2013, vol: 24, page: A73, stat: Journal Article,

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells
Baldauf, Hanna-Mari; Pan, Xiaoyu; Erikson, Elina; Schmidt, Sarah; Daddacha, Waaqo; Burggraf, Manja; Schenkova, Kristina; Ambiel, Ina; Wabnitz, Guido; Gramberg, Thomas; Panitz, Sylvia; Flory, Egbert; Landau, Nathaniel R; Sertel, Serkan; Rutsch, Frank; Lasitschka, Felix; Kim, Baek; Konig, Renate; Fackler, Oliver T; Keppler, Oliver T
2012 Nov;18(11):1682-1687, Nature medicine
— id: 185452, year: 2012, vol: 18, page: 1682, stat: Journal Article,

The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus
Hofmann, Henning; Logue, Eric C; Bloch, Nicolin; Daddacha, Waaqo; Polsky, Sylvie B; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R
2012 Dec;86(23):12552-12560, Journal of virology
— id: 184822, year: 2012, vol: 86, page: 12552, stat: Journal Article,

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
Lahouassa, Hichem; Daddacha, Waaqo; Hofmann, Henning; Ayinde, Diana; Logue, Eric C; Dragin, Loic; Bloch, Nicolin; Maudet, Claire; Bertrand, Matthieu; Gramberg, Thomas; Pancino, Gianfranco; Priet, Stephane; Canard, Bruno; Laguette, Nadine; Benkirane, Monsef; Transy, Catherine; Landau, Nathaniel R; Kim, Baek; Margottin-Goguet, Florence
2012 ;13(3):223-228, Nature immunology
— id: 158627, year: 2012, vol: 13, page: 223, stat: Journal Article,

The cargo-binding domain of transportin 3 is required for lentivirus nuclear import
Logue, Eric C; Taylor, Kayleigh T; Goff, Peter H; Landau, Nathaniel R
2011 Dec;85(24):12950-12961, Journal of virology
— id: 141700, year: 2011, vol: 85, page: 12950, stat: Journal Article,

Human immunodeficiency virus type 1 modified to package simian immunodeficiency virus vpx efficiently infects macrophages and dendritic cells
Sunseri, Nicole; O'Brien, Meagan; Bhardwaj, Nina; Landau, Nathaniel R
2011 Jul;85(13):6263-6274, Journal of virology
— id: 134443, year: 2011, vol: 85, page: 6263, stat: Journal Article,

Evidence for an Activation Domain at the Amino-terminus of SIV Vpx
Gramberg, Thomas; Sunseri, Nicole; Landau, Nathaniel R
2010 Feb;84(3):1387-1396, Journal of virology
— id: 105999, year: 2010, vol: 84, page: 1387, stat: Journal Article,

Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent
Browne, Edward P; Allers, Carolina; Landau, Nathaniel R
2009 May 10;387(2):313-321, Virology
— id: 99588, year: 2009, vol: 387, page: 313, stat: Journal Article,

Accessories to the crime: recent advances in HIV accessory protein biology
Gramberg, Thomas; Sunseri, Nicole; Landau, Nathaniel R
2009 Feb;6(1):36-42, Current HIV/AIDS reports
— id: 97756, year: 2009, vol: 6, page: 36, stat: Journal Article,

Guidelines for naming nonprimate APOBEC3 genes and proteins
LaRue, Rebecca S; Andresdottir, Valgerdur; Blanchard, Yannick; Conticello, Silvestro G; Derse, David; Emerman, Michael; Greene, Warner C; Jonsson, Stefan R; Landau, Nathaniel R; Lochelt, Martin; Malik, Harmit S; Malim, Michael H; Munk, Carsten; O'Brien, Stephen J; Pathak, Vinay K; Strebel, Klaus; Wain-Hobson, Simon; Yu, Xiao-Fang; Yuhki, Naoya; Harris, Reuben S
2009 Jan;83(2):494-497, Journal of virology
— id: 106001, year: 2009, vol: 83, page: 494, stat: Journal Article,

Inhibition of Adeno-Associated Virus by the Host Factors APOBEC3A and APOBEC3B
Narvaiza, I; Linfesty, DC; Greener, BN; Hakata, Y; Lilley, CE; Landau, NR; Weitzman, MD
2009 MAY ;17(10):S146-S146, Molecular therapy
— id: 111898, year: 2009, vol: 17, page: S146, stat: Journal Article,

Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase
Narvaiza, Inigo; Linfesty, Daniel C; Greener, Benjamin N; Hakata, Yoshiyuki; Pintel, David J; Logue, Eric; Landau, Nathaniel R; Weitzman, Matthew D
2009 May;5(5):e1000439-e1000439, PLoS pathogens
— id: 106000, year: 2009, vol: 5, page: e1000439, stat: Journal Article,

Analysis of Vif-induced APOBEC3G degradation using an alpha-complementation assay
Fang, Lei; Landau, Nathaniel R
2007 Mar 1;359(1):162-169, Virology
— id: 72039, year: 2007, vol: 359, page: 162, stat: Journal Article,

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
Schrofelbauer, Barbel; Hakata, Yoshiyuki; Landau, Nathaniel R
2007 Mar 6;104(10):4130-4135, Proceedings of the National Academy of Sciences of the United States of America
— id: 72038, year: 2007, vol: 104, page: 4130, stat: Journal Article,

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons
Chen, Hui; Lilley, Caroline E; Yu, Qin; Lee, Darwin V; Chou, Jody; Narvaiza, Inigo; Landau, Nathaniel R; Weitzman, Matthew D
2006 Mar 7;16(5):480-485, Current biology. CB
— id: 68236, year: 2006, vol: 16, page: 480, stat: Journal Article,

Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains
Hakata, Yoshiyuki; Landau, Nathaniel R
2006 Dec 1;281(48):36624-36631, Journal of biological chemistry
— id: 72040, year: 2006, vol: 281, page: 36624, stat: Journal Article,

Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G
Schrofelbauer, Barbel; Senger, Tilo; Manning, Gerard; Landau, Nathaniel R
2006 Jun;80(12):5984-5991, Journal of virology
— id: 68235, year: 2006, vol: 80, page: 5984, stat: Journal Article,

Complementary function of the two catalytic domains of APOBEC3G
Navarro, Francisco; Bollman, Brooke; Chen, Hui; Konig, Renate; Yu, Qin; Chiles, Kristopher; Landau, Nathaniel R
2005 Mar 15;333(2):374-386, Virology
— id: 68238, year: 2005, vol: 333, page: 374, stat: Journal Article,

Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases
Schrofelbauer, Barbel; Yu, Qin; Zeitlin, Samantha G; Landau, Nathaniel R
2005 Sep;79(17):10978-10987, Journal of virology
— id: 68237, year: 2005, vol: 79, page: 10978, stat: Journal Article,

Alpha-complementation assay for HIV envelope glycoprotein-mediated fusion
Holland, Anne U; Munk, Carsten; Lucero, Ginger R; Nguyen, Lucia D; Landau, Nathaniel R
2004 Feb 20;319(2):343-352, Virology
— id: 68243, year: 2004, vol: 319, page: 343, stat: Journal Article,

Recent insights into HIV-1 Vif
Navarro, Francisco; Landau, Nathaniel R
2004 Aug;16(4):477-482, Current opinion in immunology
— id: 68240, year: 2004, vol: 16, page: 477, stat: Journal Article,

A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif)
Schrofelbauer, Barbel; Chen, Darlene; Landau, Nathaniel R
2004 Mar 16;101(11):3927-3932, Proceedings of the National Academy of Sciences of the United States of America
— id: 68244, year: 2004, vol: 101, page: 3927, stat: Journal Article,

New insights into the role of Vif in HIV-1 replication
Schrofelbauer, Barbel; Yu, Qin; Landau, Nathaniel R
2004 Jan-Mar;6(1):34-39, AIDS reviews
— id: 68241, year: 2004, vol: 6, page: 34, stat: Journal Article,

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication
Yu, Qin; Chen, Darlene; Konig, Renate; Mariani, Roberto; Unutmaz, Derya; Landau, Nathaniel R
2004 Dec 17;279(51):53379-53386, Journal of biological chemistry
— id: 68239, year: 2004, vol: 279, page: 53379, stat: Journal Article,

Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
Yu, Qin; Konig, Renate; Pillai, Satish; Chiles, Kristopher; Kearney, Mary; Palmer, Sarah; Richman, Douglas; Coffin, John M; Landau, Nathaniel R
2004 May;11(5):435-442, Nature structural & molecular biology
— id: 68242, year: 2004, vol: 11, page: 435, stat: Journal Article,

HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest
Chowdhury, Iqbal H; Wang, Xiao-Fan; Landau, Nathaniel R; Robb, Merlin L; Polonis, Victoria R; Birx, Deborah L; Kim, Jerome H
2003 Jan 20;305(2):371-377, Virology
— id: 68248, year: 2003, vol: 305, page: 371, stat: Journal Article,

Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii
Golding, Hana; Aliberti, Julio; King, Lisa R; Manischewitz, Jody; Andersen, John; Valenzuela, Jesus; Landau, Nathaniel R; Sher, Alan
2003 Nov 1;102(9):3280-3286, Blood
— id: 68247, year: 2003, vol: 102, page: 3280, stat: Journal Article,

Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells
Kootstra, Neeltje A; Munk, Carsten; Tonnu, Nina; Landau, Nathaniel R; Verma, Inder M
2003 Feb 4;100(3):1298-1303, Proceedings of the National Academy of Sciences of the United States of America
— id: 68249, year: 2003, vol: 100, page: 1298, stat: Journal Article,

Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif
Mariani, Roberto; Chen, Darlene; Schrofelbauer, Barbel; Navarro, Francisco; Konig, Renate; Bollman, Brooke; Munk, Carsten; Nymark-McMahon, Henrietta; Landau, Nathaniel R
2003 Jul 11;114(1):21-31, Cell
— id: 68246, year: 2003, vol: 114, page: 21, stat: Journal Article,

The theta-defensin, retrocyclin, inhibits HIV-1 entry
Munk, Carsten; Wei, Ge; Yang, Otto O; Waring, Alan J; Wang, Wei; Hong, Teresa; Lehrer, Robert I; Landau, Nathaniel R; Cole, Alexander M
2003 Oct;19(10):875-881, AIDS research & human retroviruses
— id: 68245, year: 2003, vol: 19, page: 875, stat: Journal Article,

Association of chemokine-mediated block to HIV entry with coreceptor internalization
Brandt, Stephanie M; Mariani, Roberto; Holland, Anne U; Hope, Thomas J; Landau, Nathaniel R
2002 May 10;277(19):17291-17299, Journal of biological chemistry
— id: 68253, year: 2002, vol: 277, page: 17291, stat: Journal Article,

A cellular cofactor in HIV-1 assembly: INI1 is also an "outtie"
Landau, Nathaniel R
2002 Jun;23(6):252-253, Trends in pharmacological science
— id: 68252, year: 2002, vol: 23, page: 252, stat: Journal Article,

A dominant block to HIV-1 replication at reverse transcription in simian cells
Munk, Carsten; Brandt, Stephanie M; Lucero, Ginger; Landau, Nathaniel R
2002 Oct 15;99(21):13843-13848, Proceedings of the National Academy of Sciences of the United States of America
— id: 68250, year: 2002, vol: 99, page: 13843, stat: Journal Article,

Chimeric human immunodeficiency virus type 1 containing murine leukemia virus matrix assembles in murine cells
Reed, Margaret; Mariani, Roberto; Sheppard, Liana; Pekrun, Katja; Landau, Nathaniel R; Soong, Nay-Wei
2002 Jan;76(1):436-443, Journal of virology
— id: 68254, year: 2002, vol: 76, page: 436, stat: Journal Article,

Vpr- and Nef-dependent induction of RANTES/CCL5 in microglial cells
Si, Qiusheng; Kim, Mee-Ohk; Zhao, Meng-Liang; Landau, Nathaniel R; Goldstein, Harris; Lee, Sunhee
2002 Sep 30;301(2):342-353, Virology
— id: 68251, year: 2002, vol: 301, page: 342, stat: Journal Article,

Mouse-human heterokaryons support efficient human immunodeficiency virus type 1 assembly
Mariani, R; Rasala, B A; Rutter, G; Wiegers, K; Brandt, S M; Krausslich, H G; Landau, N R
2001 Apr;75(7):3141-3151, Journal of virology
— id: 68255, year: 2001, vol: 75, page: 3141, stat: Journal Article,

Soluble CD40 ligand induces beta-chemokine production by macrophages and resistance to HIV-1 entry
di Marzio, P; Mariani, R; Lui, R; Thomas, E K; Landau, N R
2000 Oct;12(10):1489-1495, Cytokine
— id: 68256, year: 2000, vol: 12, page: 1489, stat: Journal Article,

A block to human immunodeficiency virus type 1 assembly in murine cells
Mariani, R; Rutter, G; Harris, M E; Hope, T J; Krausslich, H G; Landau, N R
2000 Apr;74(8):3859-3870, Journal of virology
— id: 68258, year: 2000, vol: 74, page: 3859, stat: Journal Article,

Aminooxypentane addition to the chemokine macrophage inflammatory protein-1alpha P increases receptor affinities and HIV inhibition
Townson, J R; Graham, G J; Landau, N R; Rasala, B; Nibbs, R J
2000 Dec 15;275(50):39254-39261, Journal of biological chemistry
— id: 68257, year: 2000, vol: 275, page: 39254, stat: Journal Article,

HIV recent advances in AIDS research: genetics, molecular biology and immunology
Landau, N R
1999 Aug;11(4):449-450, Current opinion in immunology
— id: 68259, year: 1999, vol: 11, page: 449, stat: Journal Article,

CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function
Mariani R; Wong S; Mulder LC; Wilkinson DA; Reinhart AL; LaRosa G; Nibbs R; O'Brien TR; Michael NL; Connor RI; Macdonald M; Busch M; Koup RA; Landau NR
1999 Mar;73(3):2450-2459, Journal of virology
— id: 65550, year: 1999, vol: 73, page: 2450, stat: Journal Article,

Altered expression of CD4, CD54, CD62L, and CCR5 in primary lymphocytes productively infected with the human immunodeficiency virus
Marodon, G; Landau, N R; Posnett, D N
1999 Jan 20;15(2):161-171, AIDS research & human retroviruses
— id: 68261, year: 1999, vol: 15, page: 161, stat: Journal Article,

LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity
Nibbs, R J; Yang, J; Landau, N R; Mao, J H; Graham, G J
1999 Jun 18;274(25):17478-17483, Journal of biological chemistry
— id: 68260, year: 1999, vol: 274, page: 17478, stat: Journal Article,

HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor
Paxton WA; Kang S; Liu R; Landau NR; Gingeras TR; Wu L; Mackay CR; Koup RA
1999 Mar;66(1-3):71-75, Immunology letters
— id: 65546, year: 1999, vol: 66, page: 71, stat: Journal Article,

New developments in the biology and treatment of HIV
Bushman, F; Landau, N R; Emini, E A
1998 Sep 15;95(19):11041-11042, Proceedings of the National Academy of Sciences of the United States of America
— id: 68263, year: 1998, vol: 95, page: 11041, stat: Journal Article,

Chemokine receptor regulation and HIV type 1 tropism in monocyte-macrophages
Di Marzio, P; Tse, J; Landau, N R
1998 Jan 20;14(2):129-138, AIDS research & human retroviruses
— id: 68264, year: 1998, vol: 14, page: 129, stat: Journal Article,

Functional analysis of the proximal CCR5 promoter
Liu, R; Zhao, X; Gurney, T A; Landau, N R
1998 Nov 20;14(17):1509-1519, AIDS research & human retroviruses
— id: 68262, year: 1998, vol: 14, page: 1509, stat: Journal Article,

Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines
Paxton WA; Liu R; Kang S; Wu L; Gingeras TR; Landau NR; Mackay CR; Koup RA
1998 Apr 25;244(1):66-73, Virology
— id: 65556, year: 1998, vol: 244, page: 66, stat: Journal Article,

Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry
Chen Z; Zhou P; Ho DD; Landau NR; Marx PA
1997 Apr;71(4):2705-2714, Journal of virology
— id: 57530, year: 1997, vol: 71, page: 2705, stat: Journal Article,

Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor
Cheng-Mayer, C; Liu, R; Landau, N R; Stamatatos, L
1997 Feb;71(2):1657-1661, Journal of virology
— id: 68268, year: 1997, vol: 71, page: 1657, stat: Journal Article,

Change in coreceptor use coreceptor use correlates with disease progression in HIV-1--infected individuals
Connor, R I; Sheridan, K E; Ceradini, D; Choe, S; Landau, N R
1997 Feb 17;185(4):621-628, Journal of experimental medicine
— id: 68267, year: 1997, vol: 185, page: 621, stat: Journal Article,

HIV co-receptor identification: good or bad news for drug discovery?
Landau, N R
1997 Oct;9(5):628-630, Current opinion in immunology
— id: 68266, year: 1997, vol: 9, page: 628, stat: Journal Article,

CCR-5: A hot target for drug discovery
Landau, NR; Liu, R; DiMarzio, P; Choe, S; Ceradini, D; Yang, J; Paxton, WA; Koup, RA
1997 JUL 31 ;11(9):A855-A855, FASEB journal
— id: 146290, year: 1997, vol: 11, page: A855, stat: Journal Article,

Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6
Nibbs, R J; Wylie, S M; Yang, J; Landau, N R; Graham, G J
1997 Dec 19;272(51):32078-32083, Journal of biological chemistry
— id: 68265, year: 1997, vol: 272, page: 32078, stat: Journal Article,

Identification of a major co-receptor for primary isolates of HIV-1
Deng H; Liu R; Ellmeier W; Choe S; Unutmaz D; Burkhart M; Di Marzio P; Marmon S; Sutton RE; Hill CM; Davis CB; Peiper SC; Schall TJ; Littman DR; Landau NR
1996 Jun 20;381(6584):661-666, Nature
— id: 57390, year: 1996, vol: 381, page: 661, stat: Journal Article,

CD4-independent infection by HIV-2 is mediated by fusin/CXCR4
Endres, M J; Clapham, P R; Marsh, M; Ahuja, M; Turner, J D; McKnight, A; Thomas, J F; Stoebenau-Haggarty, B; Choe, S; Vance, P J; Wells, T N; Power, C A; Sutterwala, S S; Doms, R W; Landau, N R; Hoxie, J A
1996 Nov 15;87(4):745-756, Cell
— id: 68269, year: 1996, vol: 87, page: 745, stat: Journal Article,

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
Huang Y; Paxton WA; Wolinsky SM; Neumann AU; Zhang L; He T; Kang S; Ceradini D; Jin Z; Yazdanbakhsh K; Kunstman K; Erickson D; Dragon E; Landau NR; Phair J; Ho DD; Koup RA
1996 Nov;2(11):1240-1243, Nature medicine
— id: 65569, year: 1996, vol: 2, page: 1240, stat: Journal Article,

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
Liu R; Paxton WA; Choe S; Ceradini D; Martin SR; Horuk R; MacDonald ME; Stuhlmann H; Koup RA; Landau NR
1996 Aug 9;86(3):367-377, Cell
— id: 65571, year: 1996, vol: 86, page: 367, stat: Journal Article,

1995 APR 2 ;54(3):187-187, Journal of cellular biochemistry
— id: 87310, year: 1995, vol: 54, page: 187, stat: Journal Article,

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
Connor RI; Chen BK; Choe S; Landau NR
1995 Feb 1;206(2):935-944, Virology
— id: 6595, year: 1995, vol: 206, page: 935, stat: Journal Article,

Structural and functional studies on HIV-1 Vpr suggest the importance of a predicted alpha-helical amino-terminal domain
Di Marzio P; Choe S; Connor RI; Knoblauch R; Ebright M; Isakoff S; Landau NR
1995 Jan 29-Feb 2;2:60-60, National Conference on Human Retroviruses & Related Infections
— id: 5984, year: 1995, vol: 2, page: 60, stat: Journal Article,

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr
Di Marzio, P; Choe, S; Ebright, M; Knoblauch, R; Landau, N R
1995 Dec;69(12):7909-7916, Journal of virology
— id: 68270, year: 1995, vol: 69, page: 7909, stat: Journal Article,

1995 APR 2 ;54(3):188-188, Journal of cellular biochemistry
— id: 87311, year: 1995, vol: 54, page: 188, stat: Journal Article,

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
He J; Choe S; Walker R; Di Marzio P; Morgan DO; Landau NR
1995 Nov;69(11):6705-6711, Journal of virology
— id: 56820, year: 1995, vol: 69, page: 6705, stat: Journal Article,

Use of a novel human immunodeficiency virus type 1 reporter virus expressing human placental alkaline phosphatase to detect an alternative viral receptor
He J; Landau NR
1995 Jul;69(7):4587-4592, Journal of virology
— id: 12753, year: 1995, vol: 69, page: 4587, stat: Journal Article,

1995 APR 2 ;54(3):191-191, Journal of cellular biochemistry
— id: 87312, year: 1995, vol: 54, page: 191, stat: Journal Article,

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
Aiken, C; Konner, J; Landau, N R; Lenburg, M E; Trono, D
1994 Mar 11;76(5):853-864, Cell
— id: 68271, year: 1994, vol: 76, page: 853, stat: Journal Article,

1994 JUL ;68(7):4705-4705, Journal of virology
— id: 52430, year: 1994, vol: 68, page: 4705, stat: Journal Article,

The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef
Anderson SJ; Lenburg M; Landau NR; Garcia JV
1994 May;68(5):3092-3101, Journal of virology
— id: 57478, year: 1994, vol: 68, page: 3092, stat: Journal Article,

1993 MAR 29 ;43(4):50-50, Journal of cellular biochemistry
— id: 54213, year: 1993, vol: 43, page: 50, stat: Journal Article,

Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4
Lenburg ME; Landau NR
1993 Dec;67(12):7238-7245, Journal of virology
— id: 56555, year: 1993, vol: 67, page: 7238, stat: Journal Article,

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis
Paxton W; Connor RI; Landau NR
1993 Dec;67(12):7229-7237, Journal of virology
— id: 56571, year: 1993, vol: 67, page: 7229, stat: Journal Article,

Packaging system for rapid production of murine leukemia virus vectors with variable tropism
Landau NR; Littman DR
1992 Aug;66(8):5110-5113, Journal of virology
— id: 15154, year: 1992, vol: 66, page: 5110, stat: Journal Article,

Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range
Landau NR; Page KA; Littman DR
1991 Jan;65(1):162-169, Journal of virology
— id: 15166, year: 1991, vol: 65, page: 162, stat: Journal Article,

LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes
Lo, K; Landau, N R; Smale, S T
1991 Oct;11(10):5229-5243, Molecular & cellular biology
— id: 68272, year: 1991, vol: 11, page: 5229, stat: Journal Article,

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias
Muller AJ; Young JC; Pendergast AM; Pondel M; Landau NR; Littman DR; Witte ON
1991 Apr;11(4):1785-1792, Molecular & cellular biology
— id: 15163, year: 1991, vol: 11, page: 1785, stat: Journal Article,

Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity
Page KA; Landau NR; Littman DR
1990 Nov;64(11):5270-5276, Journal of virology
— id: 15168, year: 1990, vol: 64, page: 5270, stat: Journal Article,

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4
Landau NR; Warton M; Littman DR
1988 Jul 14;334(6178):159-162, Nature
— id: 57528, year: 1988, vol: 334, page: 159, stat: Journal Article,

2',3'-Dideoxyadenosine is selectively toxic for TdT-positive cells
Spigelman, Z; Duff, R; Beardsley, G P; Broder, S; Cooney, D; Landau, N R; Mitsuya, H; Ullman, B; McCaffrey, R
1988 Jun;71(6):1601-1608, Blood
— id: 68273, year: 1988, vol: 71, page: 1601, stat: Journal Article,

Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector
Landau, N R; Schatz, D G; Rosa, M; Baltimore, D
1987 Sep;7(9):3237-3243, Molecular & cellular biology
— id: 68274, year: 1987, vol: 7, page: 3237, stat: Journal Article,

Measurement of terminal deoxynucleotidyl transferase mRNA in clinical samples: a new parameter in analysis of leukemia cells
Wolf, S C; Steinherz, P G; Landau, N R; Silverstone, A E
1987 Jul;25(3):259-269, American journal of hematology
— id: 68275, year: 1987, vol: 25, page: 259, stat: Journal Article,

The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23----q24) and on mouse chromosome 19
Yang-Feng, T L; Landau, N R; Baltimore, D; Francke, U
1986 ;43(3-4):121-126, Cytogenetics & cell genetics
— id: 68276, year: 1986, vol: 43, page: 121, stat: Journal Article,

Cloning of terminal transferase cDNA by antibody screening
Landau, N R; St John, T P; Weissman, I L; Wolf, S C; Silverstone, A E; Baltimore, D
1984 Sep;81(18):5836-5840, Proceedings of the National Academy of Sciences of the United States of America
— id: 68277, year: 1984, vol: 81, page: 5836, stat: Journal Article,