Juan Jose Lafaille

Biosketch / Results /

Juan Jose Lafaille, Ph.D.

Professor;
Departments of Pathology (Skirball), Molecular Pathogenesis and Medicine (Administration)

Contact Info

Address
540 First Avenue
Floor 2 Room Lab 7
Skirball Institute
New York, NY 10016

212-263-1489
212-263-5711
juan.lafaille@med.nyu.edu

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Education

— Dr. Lafaille received his Ph.D. degree from the University of Sao Paulo, Brazil, Graduate Education

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Research Summary

Although most normal immune responses against pathogens require the action of T-lymphocytes, their improper control lies at the heart of two types of disease: autoimmunity and allergy. Our laboratory uses transgenic and knockout mice to study the molecular mechanisms responsible for the normal control of T-lymphocyte reactivity and the changes that occur when T-lymphocytes become either aggressive against self antigens or inappropriately reactive against substances (allergens) normally present in the environment.

Currently, we are examining the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, in transgenic mice bearing antimyelin basic protein (MBP) T-lymphocytes. Mice harboring large numbers of anti-MBP T-lymphocytes in addition to other lymphocytes seldom develop EAE spontaneously. However, when these mice are crossed with RAG-l KO mice, thereby producing only anti-MBP T-lymphocytes, they all develop spontaneous EAE. The sharp contrast in susceptibility to EAE between the two types of anti-MBP transgenic mice, one carrying regulatory lymphocytes and the other not, enables us to pursue identifying and characterizating those cells. We also focus on a transgenic mouse model for asthma to determine in vivo the factors controlling the synthesis of important interleukins involved in the asthmatic process such as IL-4 and IL-5 and the increased production of immunoglobulin E.

Research Interests

Molecular Pathogenesis of Autoimmune and Allergic Diseases

Research Keywords

allergy, autoimmunity, immunological tolerance, interleukins, mouse models, T-lymphocytes

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Massive monoclonal expansion of functionally stable human regulatory T cells
Nowatzky, J; Manches, O; Bhardwaj, N; Lafaille, J
2014 01 May 2014;192(1):-, Journal of immunology
— id: 1058252, year: 2014, vol: 192, page: , stat: Journal Article,

Focused specificity of intestinal T17 cells towards commensal bacterial antigens
Yang, Yi; Torchinsky, Miriam B; Gobert, Michael; Xiong, Huizhong; Xu, Mo; Linehan, Jonathan L; Alonzo, Francis; Ng, Charles; Chen, Alessandra; Lin, Xiyao; Sczesnak, Andrew; Liao, Jia-Jun; Torres, Victor J; Jenkins, Marc K; Lafaille, Juan J; Littman, Dan R
2014 Apr;:152-156, Nature
— id: 963022, year: 2014, vol: , page: 152, stat: Journal Article,

The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response
He, Jin-Shu; Meyer-Hermann, Michael; Xiangying, Deng; Zuan, Lim Yok; Jones, Leigh Ann; Ramakrishna, Lakshmi; de Vries, Victor C; Dolpady, Jayashree; Aina, Hoi; Joseph, Sabrina; Narayanan, Sriram; Subramaniam, Sharrada; Puthia, Manoj; Wong, Glenn; Xiong, Huizhong; Poidinger, Michael; Urban, Joseph F; Lafaille, Juan J; Curotto de Lafaille, Maria A
2013 Nov;210(12):2755-2771, Journal of experimental medicine
— id: 687432, year: 2013, vol: 210, page: 2755, stat: Journal Article,

Pillars article: High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 1994. 78: 399-408
Lafaille, Juan J; Nagashima, Kumiko; Katsuki, Motoya; Tonegawa, Susumu
2013 Apr;190(7):3028-3037, Journal of immunology
— id: 377322, year: 2013, vol: 190, page: 3028, stat: Journal Article,

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10
Oliveira, Vanessa G; Agua-Doce, Ana; Curotto de Lafaille, Maria A; Lafaille, Juan J; Graca, Luis
2013 May;121(19):3936-3945, Blood
— id: 377312, year: 2013, vol: 121, page: 3936, stat: Journal Article,

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Parkhurst, Christopher N; Yang, Guang; Ninan, Ipe; Savas, Jeffrey N; Yates, John R 3rd; Lafaille, Juan J; Hempstead, Barbara L; Littman, Dan R; Gan, Wen-Biao
2013 Dec;155(7):1596-1609, Cell
— id: 746582, year: 2013, vol: 155, page: 1596, stat: Journal Article,

Characterization of Two Distinct Lymphoproliferative Diseases Caused by Ectopic Expression of the Notch Ligand DLL4 on T Cells
Xiong, Huizhong; Maraver, Antonio; Latkowski, Jo-Ann; Henderson, Tanya; Schlessinger, Karni; Ding, Yi; Shen, Jie; Tadokoro, Carlos E; Lafaille, Juan J
2013 ;8(12):e84841-e84841 e84841, PLoS one
— id: 741062, year: 2013, vol: 8, page: e84841, stat: Journal Article,

Induced CD4(+)Foxp3(+) Regulatory T Cells in Immune Tolerance
Bilate, Angelina M; Lafaille, Juan J
2012 Apr;30:733-758, Annual review of immunology
— id: 162830, year: 2012, vol: 30, page: 733, stat: Journal Article,

Distinction between natural and adaptive Foxp3+ regulatory T cells helps to ascertain their roles in cancer and autoimmune diseases
Ding, Y; Lafaille, J
2012 July 2012;138:A067-A067, American journal of clinical pathology
— id: 179311, year: 2012, vol: 138, page: A067, stat: Journal Article,

Maternal-fetal immune tolerance, block by block
Gobert, Michael; Lafaille, Juan J
2012 Jul;150(1):7-9, Cell
— id: 171567, year: 2012, vol: 150, page: 7, stat: Journal Article,

On the differentiation of mouse IgE(+) cells
Lafaille, Juan J; Xiong, Huizhong; Curotto de Lafaille, Maria A
2012 ;13(7):623; author reply 623-623; author reply 624, Nature immunology
— id: 169495, year: 2012, vol: 13, page: 623; author reply 623, stat: Journal Article,

The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate
Mendoza, Alejandra; Breart, Beatrice; Ramos-Perez, Willy D; Pitt, Lauren A; Gobert, Michael; Sunkara, Manjula; Lafaille, Juan J; Morris, Andrew J; Schwab, Susan R
2012 Nov;2(5):1104-1110, Cell reports
— id: 288532, year: 2012, vol: 2, page: 1104, stat: Journal Article,

Progranulin Plays a Protective Role in the Pathogenesis of Inflammatory Bowel Disease
Wei, Fanhua; Jian, Jinlong; Zhang, Yuying; Lin, Jiqiang; Lafaille, Juan; Dustin, Michael; Mayer, Lloyd; Liu, Chuanju
2012 OCT;64(10 S S):S819-S819, Arthritis & rheumatism
— id: 184182, year: 2012, vol: 64, page: S819, stat: Journal Article,

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Weiss, Jonathan M; Bilate, Angelina M; Gobert, Michael; Ding, Yi; Curotto de Lafaille, Maria A; Parkhurst, Christopher N; Xiong, Huizhong; Dolpady, Jayashree; Frey, Alan B; Ruocco, Maria Grazia; Yang, Yi; Floess, Stefan; Huehn, Jochen; Oh, Soyoung; Li, Ming O; Niec, Rachel E; Rudensky, Alexander Y; Dustin, Michael L; Littman, Dan R; Lafaille, Juan J
2012 Sep;209(10):2291-2299, Journal of experimental medicine
— id: 178843, year: 2012, vol: 209, page: 2291, stat: Journal Article,

What is Unique About the IgE Response?
Xiong, Huizhong; Curotto de Lafaille, Maria A; Lafaille, Juan J
2012 ;116:113-141, Advances in immunology
— id: 180093, year: 2012, vol: 116, page: 113, stat: Journal Article,

Sequential class switching is required for the generation of high affinity IgE antibodies
Xiong, Huizhong; Dolpady, Jayashree; Wabl, Matthias; Curotto de Lafaille, Maria A; Lafaille, Juan J
2012 Feb;209(2):353-364, Journal of experimental medicine
— id: 157478, year: 2012, vol: 209, page: 353, stat: Journal Article,

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function
Zanin-Zhorov, Alexandra; Lin, Jiqiang; Scher, Jose; Kumari, Sudha; Blair, David; Hippen, Keli L; Blazar, Bruce R; Abramson, Steven B; Lafaille, Juan J; Dustin, Michael L
2012 Jan;109(5):1625-1630, Proceedings of the National Academy of Sciences of the United States of America
— id: 155928, year: 2012, vol: 109, page: 1625, stat: Journal Article,

Scaffold protein Disc-Large Homolog 1 is required for T cell receptor-induced activation of regulatory T cell function
Zanin-Zhorov, Alexandra; Lin, Jiqiang; Scher, Jose; Kumari, Sudha; Blair, David; Hippen, Keli; Blazar, Bruce; Abramson, Steven; Lafaille, Juan; Dustin, Michael
2012 MAY 1;188:-, Journal of immunology
— id: 169555, year: 2012, vol: 188, page: , stat: Journal Article,

It takes two to tango
Bilate, Angelina B; Lafaille, Juan J
2011 Jul 22;35(1):6-8, Immunity
— id: 135577, year: 2011, vol: 35, page: 6, stat: Journal Article,

Lipid phosphate phosphatase 3 enables efficient thymic egress
Breart, Beatrice; Ramos-Perez, Willy D; Mendoza, Alejandra; Salous, Abdelghaffar K; Gobert, Michael; Huang, Yong; Adams, Ralf H; Lafaille, Juan J; Escalante-Alcalde, Diana; Morris, Andrew J; Schwab, Susan R
2011 Jun 6;208(6):1267-1278, Journal of experimental medicine
— id: 134311, year: 2011, vol: 208, page: 1267, stat: Journal Article,

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity
Huh, Jun R; Leung, Monica W L; Huang, Pengxiang; Ryan, Daniel A; Krout, Michael R; Malapaka, Raghu R V; Chow, Jonathan; Manel, Nicolas; Ciofani, Maria; Kim, Sangwon V; Cuesta, Adolfo; Santori, Fabio R; Lafaille, Juan J; Xu, H Eric; Gin, David Y; Rastinejad, Fraydoon; Littman, Dan R
2011 Apr 28;472(7344):486-490, Nature
— id: 131813, year: 2011, vol: 472, page: 486, stat: Journal Article,

Can TNF-alpha boost regulatory T cells?
Bilate, Angelina M; Lafaille, Juan J
2010 Dec 1;120(12):4190-4192, Journal of clinical investigation
— id: 115425, year: 2010, vol: 120, page: 4190, stat: Journal Article,

Mechanisms of tolerance and allergic sensitization in the airways and the lungs
Curotto de Lafaille, Maria A; Lafaille, Juan J; Graca, Luis
2010 Oct;22(5):616-622, Current opinion in immunology
— id: 133816, year: 2010, vol: 22, page: 616, stat: Journal Article,

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites
Kim, Jiyun V; Jiang, Ning; Tadokoro, Carlos E; Liu, Liping; Ransohoff, Richard M; Lafaille, Juan J; Dustin, Michael L
2010 Jan 31;352(1-2):89-100, Journal of immunological methods
— id: 106273, year: 2010, vol: 352, page: 89, stat: Journal Article,

Protein kinase C-theta mediates negative feedback on regulatory T cell function
Zanin-Zhorov, Alexandra; Ding, Yi; Kumari, Sudha; Attur, Mukundan; Hippen, Keli L; Brown, Maryanne; Blazar, Bruce R; Abramson, Steven B; Lafaille, Juan J; Dustin, Michael L
2010 Apr 16;328(5976):372-376, Science
— id: 109214, year: 2010, vol: 328, page: 372, stat: Journal Article,

Cutting Edge: Intrathymic Differentiation of Adaptive Foxp3(+) Regulatory T Cells upon Peripheral Proinflammatory Immunization
Zelenay, Santiago; Bergman, Marie-Louise; Paiva, Ricardo Sousa; Lino, Andreia C.; Martins, Ana C.; Duarte, Joao H.; Moraes-Fontes, Maria F.; Bilate, Angelina M.; Lafaille, Juan J.; Demengeot, Jocelyne
2010 OCT 1 ;185(7):3829-3833, Journal of immunology
— id: 113733, year: 2010, vol: 185, page: 3829, stat: Journal Article,

Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization
Zelenay, Santiago; Bergman, Marie-Louise; Paiva, Ricardo Sousa; Lino, Andreia C; Martins, Ana C; Duarte, Joao H; Moraes-Fontes, Maria F; Bilate, Angelina M; Lafaille, Juan J; Demengeot, Jocelyne
2010 Oct;185(7):3829-3833, Journal of immunology
— id: 377332, year: 2010, vol: 185, page: 3829, stat: Journal Article,

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
Curotto de Lafaille, Maria A; Lafaille, Juan J
2009 May;30(5):626-635, Immunity
— id: 99220, year: 2009, vol: 30, page: 626, stat: Journal Article,

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
Leung, Monica W L; Shen, Shiqian; Lafaille, Juan J
2009 Sep 28;206(10):2121-2130, Journal of experimental medicine
— id: 103153, year: 2009, vol: 206, page: 2121, stat: Journal Article,

In vitro generated Th17 cells maintain cytolkine profile in wild type but not in lymphopenic hosts in experimental autoimmune encephalomyelitis
Leung, MWL; Bilate, AM; Tadokoro, CE; Lafaille, JJ
2009 OCT-NOV ;48(1-2):71-71, Cytokine
— id: 105956, year: 2009, vol: 48, page: 71, stat: Journal Article,

Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
Curotto de Lafaille, Maria A; Kutchukhidze, Nino; Shen, Shiqian; Ding, Yi; Yee, Herman; Lafaille, Juan J
2008 Jul;29(1):114-126, Immunity
— id: 80819, year: 2008, vol: 29, page: 114, stat: Journal Article,

Adaptive Foxp3+regulatory T cells
de Lafaille, MAC; Ding, Y; Lafaille, LJ
2008 SEP ;43(3):305-305, Cytokine
— id: 91473, year: 2008, vol: 43, page: 305, stat: Journal Article,

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells
Ding, Yi; Shen, Shiqian; Lino, Andreia C; Curotto de Lafaille, Maria A; Lafaille, Juan J
2008 Feb;14(2):162-169, Nature medicine
— id: 76116, year: 2008, vol: 14, page: 162, stat: Journal Article,

Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
Furtado, Glaucia C; Marcondes, Maria Cecilia G; Latkowski, Jo-Ann; Tsai, Julia; Wensky, Allen; Lafaille, Juan J
2008 Oct 1;181(7):4648-4655, Journal of immunology
— id: 91439, year: 2008, vol: 181, page: 4648, stat: Journal Article,

CXCR6 is required for T cell recruitment into injured gray matter in the context of experimental autoimmune encephalomyelitis
Kim, JY; Tadokoro, C; Shen, SQ; Ning, J; Lafaille, J; Dustin, M
2008 OCT 25 ;203(2):165-166, Journal of neuroimmunology
— id: 91493, year: 2008, vol: 203, page: 165, stat: Journal Article,

Peripherally-induced allergen-specific Foxp3+regulatory T cells are essential for the control of chronic allergic lung inflammation
de Lafaille, MAC; Kutchukhidze, N; Ding, Y; Shen, S; Lafaille, JJ
2007 JAN ;119(1):S47-S47, Journal of allergy & clinical immunology
— id: 75696, year: 2007, vol: 119, page: S47, stat: Journal Article,

Unique maturation program of the IgE response in vivo
Erazo, Agustin; Kutchukhidze, Nino; Leung, Monica; Christ, Ana P Guarnieri; Urban, Joseph F Jr; Curotto de Lafaille, Maria A; Lafaille, Juan J
2007 Feb;26(2):191-203, Immunity
— id: 71927, year: 2007, vol: 26, page: 191, stat: Journal Article,

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells
Maraver, Antonio; Tadokoro, Carlos E; Badura, Michelle L; Shen, Jie; Serrano, Manuel; Lafaille, Juan J
2007 Nov 1;110(9):3218-3225, Blood
— id: 75363, year: 2007, vol: 110, page: 3218, stat: Journal Article,

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivanov, Ivaylo I; McKenzie, Brent S; Zhou, Liang; Tadokoro, Carlos E; Lepelley, Alice; Lafaille, Juan J; Cua, Daniel J; Littman, Dan R
2006 Sep 22;126(6):1121-1133, Cell
— id: 69079, year: 2006, vol: 126, page: 1121, stat: Journal Article,

Latent TGF-{beta}1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis
Murano, Mitsuyuki; Xiong, Xiaozhong; Murano, Naoko; Salzer, James L; Lafaille, Juan J; Tsiagbe, Vincent K
2006 Jan;79(1):140-146, Journal of leukocyte biology
— id: 61318, year: 2006, vol: 79, page: 140, stat: Journal Article,

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
Tadokoro, Carlos E; Shakhar, Guy; Shen, Shiqian; Ding, Yi; Lino, Andreia C; Maraver, Antonio; Lafaille, Juan J; Dustin, Michael L
2006 Mar 20;203(3):505-511, Journal of experimental medicine
— id: 64138, year: 2006, vol: 203, page: 505, stat: Journal Article,

Do regulatory T cells play a role in the control of homeostatic proliferation?
Curotto de Lafaille, Maria A; Shen, Shiqian; Olivares-Villagomez, Danyvid; Camps-Ramirez, Marlin; Lafaille, Juan J
2005 May-Aug;24(3-4):269-284, International reviews of immunology
— id: 58702, year: 2005, vol: 24, page: 269, stat: Journal Article,

Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis
Marcondes, Maria Cecilia G; Furtado, Glaucia C; Wensky, Allen; Curotto de Lafaille, Maria A; Fox, Howard S; Lafaille, Juan J
2005 Jun;166(6):1749-1760, American journal of pathology
— id: 56086, year: 2005, vol: 166, page: 1749, stat: Journal Article,

Oral tolerance in the absence of naturally occurring Tregs
Mucida, Daniel; Kutchukhidze, Nino; Erazo, Agustin; Russo, Momtchilo; Lafaille, Juan J; Curotto de Lafaille, Maria A
2005 Jul;115(7):1923-1933, Journal of clinical investigation
— id: 56085, year: 2005, vol: 115, page: 1923, stat: Journal Article,

Control of homeostatic proliferation by regulatory T cells
Shen, Shiqian; Ding, Yi; Tadokoro, Carlos E; Olivares-Villagomez, Danyvid; Camps-Ramirez, Marlin; Curotto de Lafaille, Maria A; Lafaille, Juan J
2005 Dec;115(12):3517-3526, Journal of clinical investigation
— id: 62396, year: 2005, vol: 115, page: 3517, stat: Journal Article,

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis
Wensky, Allen K; Furtado, Glaucia C; Marcondes, Maria Cecilia Garibaldi; Chen, Shaohua; Manfra, Denise; Lira, Sergio A; Zagzag, David; Lafaille, Juan J
2005 Feb;174(3):1416-1423, Journal of immunology
— id: 159232, year: 2005, vol: 174, page: 1416, stat: Journal Article,

The role of regulatory T cells in allergy
Curotto de Lafaille, Maria A; Lafaille, Juan J
2004 Feb;25(3-4):295-310, Springer seminars in immunopathology
— id: 44895, year: 2004, vol: 25, page: 295, stat: Journal Article,

CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
Curotto de Lafaille, Maria A; Lino, Andreia C; Kutchukhidze, Nino; Lafaille, Juan J
2004 Dec 15;173(12):7259-7268, Journal of immunology
— id: 48108, year: 2004, vol: 173, page: 7259, stat: Journal Article,

T-cell receptor transgenic mice in the study of autoimmune diseases
Lafaille, Juan J
2004 Mar;22(2):95-106, Journal of autoimmunity
— id: 44896, year: 2004, vol: 22, page: 95, stat: Journal Article,

Delta-like 4 in T cell lymphoma
Latkowski, JM; Lafaille, J
2004 MAR ;122(3):A20-A20, Journal of investigative dermatology
— id: 46572, year: 2004, vol: 122, page: A20, stat: Journal Article,

Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria
Hafalla, Julius C R; Morrot, Alexandre; Sano, Gen-Ichiro; Milon, Genevieve; Lafaille, Juan J; Zavala, Fidel
2003 Jul 15;171(2):964-970, Journal of immunology
— id: 39159, year: 2003, vol: 171, page: 964, stat: Journal Article,

Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system
Yan, Shirley ShiDu; Wu, Zhi-Ying; Zhang, Hui Ping; Furtado, Glaucia; Chen, Xi; Yan, Shi Fang; Schmidt, Ann Marie; Brown, Chris; Stern, Alan; LaFaille, Juan; Chess, Leonard; Stern, David M; Jiang, Hong
2003 Mar;9(3):287-293, Nature medicine
— id: 44897, year: 2003, vol: 9, page: 287, stat: Journal Article,

CD4(+) regulatory T cells in autoimmunity and allergy
Curotto de Lafaille, Maria A; Lafaille, Juan J
2002 Dec;14(6):771-778, Current opinion in immunology
— id: 34996, year: 2002, vol: 14, page: 771, stat: Journal Article,

Removal of the deep cervical lymph nodes decreases the severity of EAE
Furtado, GC; Marcondes, MCG; Tsai, J; Latkowski, JA; Lafaille, JJ
2002 Mar 20;16(4):A715-A715, FASEB journal
— id: 27503, year: 2002, vol: 16, page: A715, stat: Journal Article,

Interleukin 2 signaling is required for CD4(+) regulatory T cell function
Furtado, Glaucia C; Curotto de Lafaille, Maria A; Kutchukhidze, Nino; Lafaille, Juan J
2002 Sep 16;196(6):851-857, Journal of experimental medicine
— id: 34997, year: 2002, vol: 196, page: 851, stat: Journal Article,

Receptor protein tyrosine phosphatase (RPTP)-beta is involved in functional recovery from demyelinating lesions of the spinal cord
Harroch, S; Casaccia-Bonnefil, P; Furtado, G; Rosenbluth, J; Chao, M; Lafaille, J; Buxbaum, J; Schlessinger, J
2002 May;(Suppl 1):S84-S84 #P328, Glia
— id: 28182, year: 2002, vol: , page: S84, stat: Journal Article,

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions
Harroch, Sheila; Furtado, Glaucia C; Brueck, Wolfgang; Rosenbluth, Jack; Lafaille, Juan; Chao, Moses; Buxbaum, Joseph D; Schlessinger, Joseph
2002 Nov;32(3):411-414, Nature genetics
— id: 66616, year: 2002, vol: 32, page: 411, stat: Journal Article,

Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice
Hori, Shohei; Haury, Matthias; Lafaille, Juan J; Demengeot, Jocelyne; Coutinho, Antonio
2002 Dec;32(12):3729-3735, European journal of immunology
— id: 34995, year: 2002, vol: 32, page: 3729, stat: Journal Article,

Autoimmunity - Immunological Yin-Yang
Lafaille, JJ; Mathis, D
2002 DEC ;14(6):741-743, Current opinion in immunology
— id: 33051, year: 2002, vol: 14, page: 741, stat: Journal Article,

Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes
de Lafaille MA; Muriglan S; Sunshine MJ; Lei Y; Kutchukhidze N; Furtado GC; Wensky AK; Olivares-Villagomez D; Lafaille JJ
2001 Nov 5;194(9):1349-1359, Journal of experimental medicine
— id: 26571, year: 2001, vol: 194, page: 1349, stat: Journal Article,

Regulatory T cells in spontaneous autoimmune encephalomyelitis
Furtado GC; Olivares-Villagomez D; Curotto de Lafaille MA; Wensky AK; Latkowski JA; Lafaille JJ
2001 Aug;182(2):122-134, Immunological reviews
— id: 32232, year: 2001, vol: 182, page: 122, stat: Journal Article,

Regulatory V[beta]14+CD4+T cells are part of the naive repertoire and their expansion results in the loss of activated V[beta]8.2+encephalitogenic T cells in vivo
Madakamutil, LT; Maricie, I; Lafaille, JJ; Sercarz, E; Kumar, V
2001 MAR 7 ;15(4):A350-A350, FASEB journal
— id: 55133, year: 2001, vol: 15, page: A350, stat: Journal Article,

Swift development of protective effector functions in naive cd8(+) t cells against malaria liver stages
Sano Gi; Hafalla JC; Morrot A; Abe R; Lafaille JJ; Zavala F
2001 Jul 16;194(2):173-180, Journal of experimental medicine
— id: 21116, year: 2001, vol: 194, page: 173, stat: Journal Article,

The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity
Wensky A; Garibaldi Marcondes MC; Lafaille JJ
2001 Sep 15;167(6):3074-3081, Journal of immunology
— id: 26621, year: 2001, vol: 167, page: 3074, stat: Journal Article,

Biological role of nervous system specific receptor tyrosine phosphatase revealed by analysis of RPTPbeta knockout mice
Harroch, S; Casaccia-Bonnefil, P; Lafaille, J; Chao, M; Custer, A; Shrager, P; Rosenbluth, J; Schlessinger, J
2000 Nov 04-09;26(1-2):?-? Abstract #4018, Abstracts (Society for Neuroscience)
— id: 16057, year: 2000, vol: 26, page: ?, stat: Journal Article,

Biological role of nervous system specific receptor tyrosine phosphatase revealed by analysis of R
Harroch, S; Casaccia-Bonnefil, P; Lafaille, J; Chao, M; Rosenbluth, J; Verdugo-Garcia, JM; Schlessinger, J
2000 DEC ;11(2):401A-401A, Molecular biology of the cell
— id: 55212, year: 2000, vol: 11, page: 401A, stat: Journal Article,

Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis
Olivares-Villagomez D; Wensky AK; Wang Y; Lafaille JJ
2000 May 15;164(10):5499-5507, Journal of immunology
— id: 11715, year: 2000, vol: 164, page: 5499, stat: Journal Article,

Distinct T-helper type 2 populations: Implications for variable TH2-mediated pathologies in autoimmunity, disease, and infection
Wensky, A K; Marcondes, M C; Lafaille, J J
2000 May 12-16;14(6):A1217-A1217, FASEB journal
— id: 15770, year: 2000, vol: 14, page: A1217, stat: Journal Article,

CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis
Oliveira-dos-Santos AJ; Ho A; Tada Y; Lafaille JJ; Tonegawa S; Mak TW; Penninger JM
1999 Apr 15;162(8):4490-4495, Journal of immunology
— id: 18699, year: 1999, vol: 162, page: 4490, stat: Journal Article,

The role of helper T cell subsets in autoimmune diseases
Lafaille JJ
1998 Jun;9(2):139-151, Cytokine & growth factor reviews
— id: 57047, year: 1998, vol: 9, page: 139, stat: Journal Article,

Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
Olivares-Villagomez D; Wang Y; Lafaille JJ
1998 Nov 16;188(10):1883-1894, Journal of experimental medicine
— id: 7724, year: 1998, vol: 188, page: 1883, stat: Journal Article,

Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
Lafaille JJ; Keere FV; Hsu AL; Baron JL; Haas W; Raine CS; Tonegawa S
1997 Jul 21;186(2):307-312, Journal of experimental medicine
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The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci
Pereira P; Lafaille JJ; Gerber D; Tonegawa S
1997 May 27;94(11):5761-5766, Proceedings of the National Academy of Sciences of the United States of America
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High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
Lafaille JJ; Nagashima K; Katsuki M; Tonegawa S
1994 Aug 12;78(3):399-408, Cell
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T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes
Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S
1993 Feb 12;72(3):337-348, Cell
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Trypanosoma cruzi flagellar repetitive antigen expression by recombinant baculovirus: towards an improved diagnostic reagent for Chagas' disease
dos Santos CN; Krieger MA; Almeida E; Lafaille JJ; Goldenberg S; Galler R
1992 Nov;10(11):1474-1477, Bio/technology (NY)
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Use of recombinant antigens for the accurate immunodiagnosis of Chagas' disease
Krieger MA; Almeida E; Oelemann W; Lafaille JJ; Pereira JB; Krieger H; Carvalho MR; Goldenberg S
1992 Apr;46(4):427-434, American journal of tropical medicine & hygiene
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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
Mombaerts P; Clarke AR; Rudnicki MA; Iacomini J; Itohara S; Lafaille JJ; Wang L; Ichikawa Y; Jaenisch R; Hooper ML; et al.
1992 Nov 19;360(6401):225-231, Nature
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Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia
Itohara S; Farr AG; Lafaille JJ; Bonneville M; Takagaki Y; Haas W; Tonegawa S
1990 Feb 22;343(6260):754-757, Nature
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Positive selection of gamma delta T cells
Lafaille JJ; Haas W; Coutinho A; Tonegawa S
1990 Mar;11(3):75-78, Immunology today
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Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining
Lafaille JJ; DeCloux A; Bonneville M; Takagaki Y; Tonegawa S
1989 Dec 1;59(5):859-870, Cell
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Structure and expression of two Trypanosoma cruzi genes encoding antigenic proteins bearing repetitive epitopes
Lafaille JJ; Linss J; Krieger MA; Souto-Padron T; de Souza W; Goldenberg S
1989 Jun 15;35(2):127-136, Molecular & biochemical parasitology
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Strain specific protective immunity against Trypanosoma cruzi
Kloetzel JK; Lafaille JJ
1983 Apr;69(2):267-270, Journal of parasitology
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