Michelle Krogsgaard, Ph.D.

Assistant Professor;
Departments of Pathology and NYU Cancer Institute (Research-Fac)

Contact Info

Address
522 First Ave
Floor 13th floor Room 1311
Smilow Research Building
New York, NY 10016

Phone: 212-263-9266
Fax: (212)-263-9250
Email: Michelle.Krogsgaard@nyumc.org

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Education

1996-1999 — University of Copenhagen, Graduate Education
1999-2002 — Stanford University SoM, PostDoctoral Training

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Research Summary

The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to `self' (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes). Supported by the Pew Trust, Cancer Research Institute (CRI), The Arthritis Foundation; New York Chapter, American Cancer Society (ACS), NCI/NIH and NIGMS/NIH.

Research Interests

T-cell recognition and sensitivity, cancer immunology, autoimmunity, receptor signaling

Grant Keywords

Autoimmunity, Cancer Biology, Immunology

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Engineering improved T cell receptors using an alanine-scan guided T cell display selection system
Malecek, Karolina; Zhong, Shi; McGary, Katelyn; Yu, Connie; Huang, Kevin; Johnson, Laura A; Rosenberg, Steven A; Krogsgaard, Michelle
2013 Jun;392(1-2):1-11, Journal of immunological methods
— id: 315962, year: 2013, vol: 392, page: 1, stat: Journal Article,

Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors
Wan, Qi; Kozhaya, Lina; Imberg, Keren; Mercer, Frances; Zhong, Shi; Krogsgaard, Michelle; Unutmaz, Derya
2013 ;8(2):e56302-e56302 e56302, PLoS ONE
— id: 287192, year: 2013, vol: 8, page: e56302, stat: Journal Article,

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
Zhong, Shi; Malecek, Karolina; Johnson, Laura A; Yu, Zhiya; Vega-Saenz de Miera, Eleazar; Darvishian, Farbod; McGary, Katelyn; Huang, Kevin; Boyer, Josh; Corse, Emily; Shao, Yongzhao; Rosenberg, Steven A; Restifo, Nicholas P; Osman, Iman; Krogsgaard, Michelle
2013 Apr;110(17):6973-6978, Proceedings of the National Academy of Sciences of the United States of America
— id: 304932, year: 2013, vol: 110, page: 6973, stat: Journal Article,

TILs in metastatic melanoma tumors: A biomarker for immunotherapy?
Chandra, S; Ding, Y; Ma, M W; Bannan, M; Darvishian, F; Berman, R S; Shapiro, R; Krogsgaard, M; Osman, I; Pavlick, A C
2012 20 May 2012;30(15):-, Journal of clinical oncology
— id: 249972, year: 2012, vol: 30, page: , stat: Journal Article,

Mage-a3 specific t-cell receptor adoptive cell transfer of multiple myeloma
Park, J; Zhong, S; Krogsgaard, M; Mazumder, A
2012 16 Nov 2012;:-, Blood
— id: 217022, year: 2012, vol: , page: , stat: Journal Article,

Attenuated T cell responses to a high-potency ligand in vivo. L
Corse, Emily; Gottschalk, Rachel A; Krogsgaard, Michelle; Allison, James P
2010 ;8(9):?-?, PLoS biology
— id: 112589, year: 2010, vol: 8, page: ?, stat: Journal Article,

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
Juang, Jeremy; Ebert, Peter J R; Feng, Dan; Garcia, K Christopher; Krogsgaard, Michelle; Davis, Mark M
2010 Jun 7;207(6):1223-1234, Journal of experimental medicine
— id: 109693, year: 2010, vol: 207, page: 1223, stat: Journal Article,

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
Mouquet, Hugo; Scheid, Johannes F; Zoller, Markus J; Krogsgaard, Michelle; Ott, Rene G; Shukair, Shetha; Artyomov, Maxim N; Pietzsch, John; Connors, Mark; Pereyra, Florencia; Walker, Bruce D; Ho, David D; Wilson, Patrick C; Seaman, Michael S; Eisen, Herman N; Chakraborty, Arup K; Hope, Thomas J; Ravetch, Jeffrey V; Wardemann, Hedda; Nussenzweig, Michel C
2010 Sep 30;467(7315):591-595, Nature
— id: 113743, year: 2010, vol: 467, page: 591, stat: Journal Article,

Retroviral Transduction of T-cell Receptors in Mouse T-cells
Zhong, Shi; Malecek, Karolina; Perez-Garcia, Arianne; Krogsgaard, Michelle
2010 ;(44):?-?, Journal of visualized experiments : JoVE
— id: 114202, year: 2010, vol: , page: ?, stat: Journal Article,

In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange
Call, MJ; Xing, XC; Cuny, GD; Seth, NP; Altmann, DM; Fugger, L; Krogsgaard, M; Stein, RL; Wucherpfennig, KW
2009 MAY 15 ;182(10):6342-6352, Journal of immunology
— id: 99162, year: 2009, vol: 182, page: 6342, stat: Journal Article,

Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research
Wich, Lindsay G; Hamilton, Heather K; Shapiro, Richard L; Pavlick, Anna; Berman, Russell S; Polsky, David; Goldberg, Judith D; Hernando, Eva; Manga, Prashiela; Krogsgaard, Michelle; Kamino, Hideko; Darvishian, Farbod; Lee, Peng; Orlow, Seth J; Ostrer, Harry; Bhardwaj, Nina; Osman, Iman
2009 ;1(1):35-43, American Journal of Translational Research
— id: 105566, year: 2009, vol: 1, page: 35, stat: Journal Article,

T Cells as a Self-Referential, Sensory Organ
Davis, Mark M; Krogsgaard, Michelle; Huse, Morgan; Huppa, Johannes; Lillemeier, Bjoern F; Li, Qi-jing
2007 Apr 23;25:681-695, Annual review of immunology
— id: 71174, year: 2007, vol: 25, page: 681, stat: Journal Article,

A role for "self" in T-cell activation
Krogsgaard, Michelle; Juang, Jeremy; Davis, Mark M
2007 Aug;19(4):236-244, Seminars in immunology
— id: 73008, year: 2007, vol: 19, page: 236, stat: Journal Article,

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions
Qi, Shuyan; Krogsgaard, Michelle; Davis, Mark M; Chakraborty, Arup K
2006 Mar 21;103(12):4416-4421, Proceedings of the National Academy of Sciences of the United States of America
— id: 64531, year: 2006, vol: 103, page: 4416, stat: Journal Article,

Quantitative imaging of lymphocyte membrane protein reorganization and signaling
Kasson, Peter M; Huppa, Johannes B; Krogsgaard, Michelle; Davis, Mark M; Brunger, Axel T
2005 Jan;88(1):579-589, Biophysical journal
— id: 62707, year: 2005, vol: 88, page: 579, stat: Journal Article,

How T cells 'see' antigen
Krogsgaard, Michelle; Davis, Mark M
2005 Mar;6(3):239-245, Nature immunology
— id: 62706, year: 2005, vol: 6, page: 239, stat: Journal Article,

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
Krogsgaard, Michelle; Li, Qi-Jing; Sumen, Cenk; Huppa, Johannes B; Huse, Morgan; Davis, Mark M
2005 Mar 10;434(7030):238-243, Nature
— id: 62705, year: 2005, vol: 434, page: 238, stat: Journal Article,

High-level bacterial secretion of single-chain alphabeta T-cell receptors
Maynard, Jennifer; Adams, Erin J; Krogsgaard, Michelle; Petersson, Karin; Liu, Corey W; Garcia, K Christopher
2005 Nov 30;306(1-2):51-67, Journal of immunological methods
— id: 62703, year: 2005, vol: 306, page: 51, stat: Journal Article,

Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene
Ranheim, Erik A; Tarbell, Kristin V; Krogsgaard, Michelle; Mallet-Designe, Valerie; Teyton, Luc; McDevitt, Hugh O; Weissman, Irving L
2004 Dec;37(8):555-567, Autoimmunity
— id: 62704, year: 2004, vol: 37, page: 555, stat: Journal Article,

Distinct molecular mechanisms account for the specificity of two different T-cell receptors
Anikeeva, Nadja; Lebedeva, Tatiana; Krogsgaard, Michelle; Tetin, Sergey Y; Martinez-Hackert, Erik; Kalams, Spyros A; Davis, Mark M; Sykulev, Yuri
2003 Apr 29;42(16):4709-4716, Biochemistry
— id: 62711, year: 2003, vol: 42, page: 4709, stat: Journal Article,

Dynamics of cell surface molecules during T cell recognition
Davis, Mark M; Krogsgaard, Michelle; Huppa, Johannes B; Sumen, Cenk; Purbhoo, Marco A; Irvine, Darrell J; Wu, Lawren C; Ehrlich, Lauren
2003 ;72:717-742, Annual review of biochemistry
— id: 62710, year: 2003, vol: 72, page: 717, stat: Journal Article,

Linking molecular and cellular events in T-cell activation and synapse formation
Krogsgaard, Michelle; Huppa, Johannes B; Purbhoo, Marco A; Davis, Mark M
2003 Dec;15(6):307-315, Seminars in immunology
— id: 62708, year: 2003, vol: 15, page: 307, stat: Journal Article,

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
Krogsgaard, Michelle; Prado, Nelida; Adams, Erin J; He, Xiao-lin; Chow, Dar-Chone; Wilson, Darcy B; Garcia, K Christopher; Davis, Mark M
2003 Dec;12(6):1367-1378, Molecular cell
— id: 62709, year: 2003, vol: 12, page: 1367, stat: Journal Article,

Direct observation of ligand recognition by T cells
Irvine, Darrell J; Purbhoo, Marco A; Krogsgaard, Michelle; Davis, Mark M
2002 Oct 24;419(6909):845-849, Nature
— id: 62712, year: 2002, vol: 419, page: 845, stat: Journal Article,

Phage-display libraries of murine and human anitbody fab fragments
Engberg J; Johansen LK; Westengaard-Hildinge M; Riise ES; Albrechtsen B
The Nucleic acid protocols handbook Totowa NJ : Humana Press, 2000,
— id: 4013, year: 2000, vol: , page: 449, stat: Chapter,

Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex
Krogsgaard M; Wucherpfennig KW; Cannella B; Hansen BE; Svejgaard A; Pyrdol J; Ditzel H; Raine C; Engberg J; Fugger L
2000 Apr 17;191(8):1395-1412, Journal of experimental medicine
— id: 64532, year: 2000, vol: 191, page: 1395, stat: Journal Article,

Recombinant antibodies with the antigen-specific, MHC restricted specificity of T cells: novel reagents for basic and clinical investigations and immunotherapy
Engberg J; Krogsgaard M; Fugger L
1999 Mar;4(3-4):273-278, Immunotechnology
— id: 64534, year: 1999, vol: 4, page: 273, stat: Journal Article,

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
Madsen LS; Andersson EC; Jansson L; krogsgaard M; Andersen CB; Engberg J; Strominger JL; Svejgaard A; Hjorth JP; Holmdahl R; Wucherpfennig KW; Fugger L
1999 Nov;23(3):343-347, Nature genetics
— id: 64533, year: 1999, vol: 23, page: 343, stat: Journal Article,