Michelle Krogsgaard

Biosketch / Results /

Michelle Krogsgaard

Associate Professor, Department of Pathology

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-9266
Michelle.Krogsgaard@nyumc.org

Research Summary

The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to `self' (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes). Supported by the Pew Trust, Cancer Research Institute (CRI), The Arthritis Foundation; New York Chapter, American Cancer Society (ACS), NCI/NIH and NIGMS/NIH.

Research Interests

T-cell recognition and sensitivity, cancer immunology, autoimmunity, receptor signaling

Constitutive LcK activity drives sensitivity differences between CD8+memory T cell subsets
Krogsgaard, Michelle; Moogk, Duane; Zhong, Shi; Rittase, William; Fang, Victoria; Dougherty, Janna; Perez-Garcia, Arianne; Osman, Iman; Zhu, Cheng; Varadarajan, Navin; Restifo, Nicholas P; Frey, Alan B. Constitutive LcK activity drives sensitivity differences between CD8+memory T cell subsets [Meeting Abstract]. Journal of immunology (1950). 2016 MAY 1;196:?-? (2220222)

Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets
Moogk, Duane; Zhong, Shi; Yu, Zhiya; Liadi, Ivan; Rittase, William; Fang, Victoria; Dougherty, Janna; Perez-Garcia, Arianne; Osman, Iman; Zhu, Cheng; Varadarajan, Navin; Restifo, Nicholas P; Frey, Alan B; Krogsgaard, Michelle. Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. Journal of immunology (1950). 2016 Jun 6;197(2):644-654 (2136402)

Structural Model of the Extracellular Assembly of the TCR-CD3 Complex
Natarajan, Aswin; Nadarajah, Vidushan; Felsovalyi, Klara; Wang, Wenjuan; Jeyachandran, Vivian R; Wasson, Riley A; Cardozo, Timothy; Bracken, Clay; Krogsgaard, Michelle. Structural Model of the Extracellular Assembly of the TCR-CD3 Complex. Cell reports. 2016 Mar 17;14(12):2833-2845 (2051952)

The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis
Vogelsang, Matjaz; Martinez, Carlos N; Rendleman, Justin; Bapodra, Anuj Bapodra; Malecek, Karolina; Romanchuk, Artur; Kazlow, Esther; Shapiro, Richard L; Berman, Russell S; Krogsgaard, Michelle; Osman, Iman; Kirchhoff, Tomas. The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis. Clinical cancer research. 2016 Jan 5;22(13):3268-3280 (1901132)

Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts
Weiss, Sarah A; Han, Joseph; Darvishian, Farbod; Tchack, Jeremy; Han, Sung Won; Malecek, Karolina; Krogsgaard, Michelle; Osman, Iman; Zhong, Judy. Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts. Journal of translational medicine. 2016 Oct;14(1):299-299 (2280042)