Michelle Krogsgaard

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Michelle Krogsgaard

Assistant Professor, Department of Pathology
Perlmutter Cancer Center

Contact Info

522 First Avenue
New York, NY 10016



1996-1999 — University of Copenhagen, Graduate Education
1999-2002 — Stanford University SoM, PostDoctoral Training

Research Summary

The goal of the Krogsgaard laboratory is to understand the molecular and cellular events that contribute to T-cell sensitivity to `self' (cancer) antigens. To accomplish this we employ advanced and highly innovative methods that combine state-of-the-art biophysical methods for characterizing protein-protein interactions e.g. surface plasmon resonance (SPR), X-ray crystallography, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy with imaging methods (single molecule imaging and FRET) and transgenic TCR technologies which makes our research highly interdisciplinary in its nature. Our research is important not only for understanding the activation of signaling pathways important for T cell function but also for the purpose of modulating signaling through the TCR pharmacologically in new and innovative approaches. This is with the purpose of increasing the sensitivity of T-cells in patients with cancer or HIV or decreasing the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes). Supported by the Pew Trust, Cancer Research Institute (CRI), The Arthritis Foundation; New York Chapter, American Cancer Society (ACS), NCI/NIH and NIGMS/NIH.

Research Interests

T-cell recognition and sensitivity, cancer immunology, autoimmunity, receptor signaling

Genetic associations of the interleukin locus at 1q32.1 with clinical outcomes of cutaneous melanoma
Rendleman, Justin; Vogelsang, Matjaz; Bapodra, Anuj; Adaniel, Christina; Silva, Ines; Moogk, Duane; Martinez, Carlos N; Fleming, Nathaniel; Shields, Jerry; Shapiro, Richard; Berman, Russell; Pavlick, Anna; Polsky, David; Shao, Yongzhao; Osman, Iman; Krogsgaard, Michelle; Kirchhoff, Tomas
2015-01-26; 0022-2593,Journal of medical genetics - id: 1440102, year: 2015 JOURNAL ARTICLE

TCR Microclusters Pre-Exist and Contain Molecules Necessary for TCR Signal Transduction
Crites, Travis J; Padhan, Kartika; Muller, James; Krogsgaard, Michelle; Gudla, Prabhakar R; Lockett, Stephen J; Varma, Rajat
2014-06-30; 0022-1767,Journal of immunology (1950) - id: 1051812, year: 2014 Journal Article

Imprinting of the mature T cell response by self
Krogsgaard, Michelle
2014-04-22; 1471-4906,Trends in immunology - id: 883542, year: 2014 Journal Article

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system
Liu, Baoyu; Zhong, Shi; Malecek, Karolina; Johnson, Laura A; Rosenberg, Steven A; Zhu, Cheng; Krogsgaard, Michelle
2014-02-03; 0014-2980,European journal of immunology - id: 782802, year: 2014 Journal Article

Specific Increase in Potency via Structure-Based Design of a TCR
Malecek, Karolina; Grigoryan, Arsen; Zhong, Shi; Gu, Wei Jun; Johnson, Laura A; Rosenberg, Steven A; Cardozo, Timothy; Krogsgaard, Michelle
2014-08-03; 0022-1767,Journal of immunology (1950) - id: 1089952, year: 2014 JOURNAL ARTICLE