Tomas Kirchhoff

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Tomas Kirchhoff

Assistant Professor, Department of Population Health;Assistant Professor, Department of Environmental Medicine
Perlmutter Cancer Center

Contact Info

522 First Avenue
New York, NY 10016


Research Summary

The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.

Skin cancer risk in BRCA1/2 mutation carriers
Gumaste, P V; Penn, L A; Cymerman, R M; Kirchhoff, T; Polsky, D; McLellan, B
2015-06-08; 1365-2133,British journal of dermatology - id: 1616052, year: 2015 Journal Article

Genetic associations of the interleukin locus at 1q32.1 with clinical outcomes of cutaneous melanoma
Rendleman, Justin; Vogelsang, Matjaz; Bapodra, Anuj; Adaniel, Christina; Silva, Ines; Moogk, Duane; Martinez, Carlos N; Fleming, Nathaniel; Shields, Jerry; Shapiro, Richard; Berman, Russell; Pavlick, Anna; Polsky, David; Shao, Yongzhao; Osman, Iman; Krogsgaard, Michelle; Kirchhoff, Tomas
2015-01-26; 0022-2593,Journal of medical genetics - id: 1440102, year: 2015 JOURNAL ARTICLE

PP6C Hotspot Mutations in Melanoma Display Sensitivity to Aurora Kinase Inhibition
Gold, Heidi L; Wengrod, Jordan; de Miera, Eleazar Vega-Saenz; Wang, Ding; Fleming, Nathaniel; Sikkema, Lisa; Kirchhoff, Tomas; Hochman, Tsivia; Goldberg, Judith D; Osman, Iman; Gardner, Lawrence B
2014-04-22; 1541-7786,Molecular cancer research - id: 883502, year: 2014 Journal Article

Genetic Variation in DNA Repair Pathways and Risk of Non-Hodgkin's Lymphoma
Rendleman, Justin; Antipin, Yevgeniy; Reva, Boris; Adaniel, Christina; Przybylo, Jennifer A; Dutra-Clarke, Ana; Hansen, Nichole; Heguy, Adriana; Huberman, Kety; Borsu, Laetitia; Paltiel, Ora; Ben-Yehuda, Dina; Brown, Jennifer R; Freedman, Arnold S; Sander, Chris; Zelenetz, Andrew; Klein, Robert J; Shao, Yongzhao; Lacher, Mortimer; Vijai, Joseph; Offit, Kenneth; Kirchhoff, Tomas
2014-07-25; 1932-6203,PLoS one - id: 1074882, year: 2014 Journal Article

Introduction to epidemiology of breast and ovarian cancers
Adaniel, C; Kirchhoff, T
2013-11-04; 0923-7534,Annals of oncology - id: 598502, year: 2013 Journal Article