Tomas Kirchhoff

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Tomas Kirchhoff

Assistant Professor, Department of Population Health
Assistant Professor, Department of Environmental Medicine


Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-9418
Tomas.Kirchhoff@nyumc.org

Research Summary

The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.

Genetic markers of pigmentation are novel risk loci for uveal melanoma
Ferguson, Robert; Vogelsang, Matjaz; Ucisik-Akkaya, Esma; Rai, Karan; Pilarski, Robert; Martinez, Carlos N; Rendleman, Justin; Kazlow, Esther; Nagdimov, Khagay; Osman, Iman; Klein, Robert J; Davidorf, Frederick H; Cebulla, Colleen M; Abdel-Rahman, Mohamed H; Kirchhoff, Tomas. Genetic markers of pigmentation are novel risk loci for uveal melanoma. Scientific reports. 2016 ;6:31191-31191 (2211632)

The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis
Vogelsang, Matjaz; Martinez, Carlos N; Rendleman, Justin; Bapodra, Anuj Bapodra; Malecek, Karolina; Romanchuk, Artur; Kazlow, Esther; Shapiro, Richard L; Berman, Russell S; Krogsgaard, Michelle; Osman, Iman; Kirchhoff, Tomas. The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis. Clinical cancer research. 2016 Jan 5;22(13):3268-3280 (1901132)

Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
Clendenen, Tess V; Ge, Wenzhen; Koenig, Karen L; Axelsson, Tomas; Liu, Mengling; Afanasyeva, Yelena; Andersson, Anne; Arslan, Alan A; Chen, Yu; Hallmans, Goran; Lenner, Per; Kirchhoff, Tomas; Lundin, Eva; Shore, Roy E; Sund, Malin; Zeleniuch-Jacquotte, Anne. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. PLoS one. 2015 Oct 21;10(10):e0140478-e0140478 e0140478 (1810082)

Genotyping of Single Nucleotide Polymorphisms in DNA Isolated from Serum Using Sequenom MassARRAY Technology
Clendenen, Tess V; Rendleman, Justin; Ge, Wenzhen; Koenig, Karen L; Wirgin, Isaac; Currie, Diane; Shore, Roy E; Kirchhoff, Tomas; Zeleniuch-Jacquotte, Anne. Genotyping of Single Nucleotide Polymorphisms in DNA Isolated from Serum Using Sequenom MassARRAY Technology. PLoS one. 2015 Aug 14;10(8):e0135943-e0135943 e0135943 (1721892)

Skin cancer risk in BRCA1/2 mutation carriers
Gumaste, P V; Penn, L A; Cymerman, R M; Kirchhoff, T; Polsky, D; McLellan, B. Skin cancer risk in BRCA1/2 mutation carriers. British journal of dermatology. 2015 Apr 29;172(6):1498-1506 (1616052)