Tomas Kirchhoff

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Tomas Kirchhoff

Associate Professor, Department of Population Health
Associate Professor, Department of Environmental Medicine


Contact Info

Address
522 First Avenue
New York, NY 10016

917-539-5975
Tomas.Kirchhoff@nyumc.org

Research Summary

The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.

Research Keywords

cancer, computational biology, epidemiology, genomics

Genetic markers of pigmentation are novel risk loci for uveal melanoma
Ferguson, Robert; Vogelsang, Matjaz; Ucisik-Akkaya, Esma; Rai, Karan; Pilarski, Robert; Martinez, Carlos N; Rendleman, Justin; Kazlow, Esther; Nagdimov, Khagay; Osman, Iman; Klein, Robert J; Davidorf, Frederick H; Cebulla, Colleen M; Abdel-Rahman, Mohamed H; Kirchhoff, Tomas. Genetic markers of pigmentation are novel risk loci for uveal melanoma. Scientific reports. 2016 Aug 08;6:31191-31191 (2211632)

The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis
Vogelsang, Matjaz; Martinez, Carlos N; Rendleman, Justin; Bapodra, Anuj Bapodra; Malecek, Karolina; Romanchuk, Artur; Kazlow, Esther; Shapiro, Richard L; Berman, Russell S; Krogsgaard, Michelle; Osman, Iman; Kirchhoff, Tomas. The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis. Clinical cancer research. 2016 Jul 01;22(13):3268-3280 (1901132)

Identification of a novel pathogenic germline KDR variant in melanoma
Pires Silva, Ines; Salhi, Amel; Giles, Keith M; Vogelsang, Matjaz; Han, Sung Won; Ismaili, Naima; Lui, Kevin P; Robinson, Eric M; Wilson, Melissa A; Shapiro, Richard L; Pavlick, Anna; Zhong, Judy; Kirchhoff, Tomas; Osman, Iman. Identification of a novel pathogenic germline KDR variant in melanoma. Clinical cancer research. 2016 May 15;22(10):2377-2385 (1863552)

Germline determinants of clinical outcome of cutaneous melanoma
Vogelsang, Matjaz; Wilson, Melissa; Kirchhoff, Tomas. Germline determinants of clinical outcome of cutaneous melanoma. Pigment cell & melanoma research. 2016 Jan;29(1):15-26 (1762052)

Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis
Weiss, Sarah; Darvishian, Farbod; Tadepalli, Jyothi; Shapiro, Richard; Golfinos, John; Pavlick, Anna; Polsky, David; Kirchhoff, Tomas; Osman, Iman. Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis. BMC cancer. 2015 Nov 23;15:926-926 (1856342)