Chunyuan Jin

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Chunyuan Jin, M.D., D.Phil.

Assistant Professor;
Departments of Environmental Medicine and Biochemistry and Molecular Pharmacology

Contact Info

Address

57 Old Forge Road Floor 2 Room 274A
Sterling Forest
Tuxedo, NY 10987

845-731-3602
845-351-5472
Chunyuan.Jin@nyumc.org

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Research Summary

In eukaryotic cells, DNA is packaged into a DNA-protein complex called chromatin. The fundamental subunit of chromatin is the nucleosome core particle, which consists of 147 base pairs of DNA wrapped around a histone octamer. Chromatin structure regulates the access of regulatory factors to the genomic DNA and thus exerts a profound control over most DNA-templated processes such as transcription, DNA repair and replication. Elucidating the interaction between chromatin structure and these nuclear processes is critical for understanding of development and human disease. Chromatin structure can be altered by several epigenetic mechanisms including DNA methylation, post-translational histone modifications, and the assembly of variant histones into chromatin. Our research focuses on how epigenetic mechanisms, in particular the incorporation of histone variants into nucleosome, modulate chromatin structure and gene expression. Another focus in our laboratory involves understanding the mechanisms of both assembly/disassembly and replication of nucleosomes containing histone variant(s). We are also interested in the mechanisms by which environmental factors influence epigenetic profiles of normal cells and contribute to carcinogenesis.

Research Interests

Chromatin structure, epigenetic mechanisms, histone variants, gene expression, carcinogenesis

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Environmental stress-induced Chromatin Regulation and its Heritability
Fang, Lei; Wuptra, Kenly; Chen, Danqi; Li, Hongjie; Huang, Shau-Ku; Jin, Chunyuan; Yokoyama, Kazunari K
2014 ;5(1):?-? #1000156, Journal of carcinogenesis & mutagenesis
— id: 816312, year: 2014, vol: 5, page: ?, stat: Journal Article,

Bovine Induced Pluripotent Stem Cells Are More Resistant to Apoptosis than Testicular Cells in Response to Mono-(2-ethylhexyl) Phthalate
Lin, Ying-Chu; Kuo, Kung-Kai; Wuputra, Kenly; Lin, Shih-Han; Ku, Chia-Chen; Yang, Ya-Han; Wang, Shin-Wei; Wang, Sheng-Wen; Wu, Deng-Chyang; Wu, Chun-Chien; Chai, Chee-Yin; Lin, Cheng-Lung; Lin, Chang-Shen; Kajitani, Masayuki; Miyoshi, Hiroyuki; Nakamura, Yukio; Hashimoto, Shinichi; Matsushima, Kouji; Jin, Chunyuan; Huang, Shau-Ku; Saito, Shigeo; Yokoyama, Kazunari K
2014 ;15(3):5011-5031, International journal of molecular sciences
— id: 863272, year: 2014, vol: 15, page: 5011, stat: Journal Article,

Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation
Chen, Danqi; Fang, Lei; Li, Hongjie; Tang, Moon-Shong; Jin, Chunyuan
2013 Jun;:21678-21687, Journal of biological chemistry
— id: 383082, year: 2013, vol: , page: 21678, stat: Journal Article,

Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis
Tanigawa, S; Lee, C H; Lin, C S; Ku, C C; Hasegawa, H; Qin, S; Kawahara, A; Korenori, Y; Miyamori, K; Noguchi, M; Lee, L H; Lin, Y C; Steve Lin, C L; Nakamura, Y; Jin, C; Yamaguchi, N; Eckner, R; Hou, D-X; Yokoyama, K K
2013 ;4:e921-e921 e921, Cell death & disease
— id: 657932, year: 2013, vol: 4, page: e921, stat: Journal Article,

Androgen receptor-mediated apoptosis in bovine testicular induced pluripotent stem cells in response to phthalate esters
Wang, S-W; Wang, S S-W; Wu, D-C; Lin, Y-C; Ku, C-C; Wu, C-C; Chai, C-Y; Lee, J-N; Tsai, E-M; Lin, C-Ls; Yang, R-C; Ko, Y-C; Yu, H-S; Huo, C; Chuu, C-P; Murayama, Y; Nakamura, Y; Hashimoto, S; Matsushima, K; Jin, C; Eckner, R; Lin, C-S; Saito, S; Yokoyama, K K
2013 ;4:e907-e907 e907, Cell death & disease
— id: 657942, year: 2013, vol: 4, page: e907, stat: Journal Article,

Chromatin boundaries, insulators, and long-range interactions in the nucleus
Giles, K E; Gowher, H; Ghirlando, R; Jin, C; Felsenfeld, G
2010 ;75:79-85, Cold Spring Harbor symposia on quantitative biology
— id: 138261, year: 2010, vol: 75, page: 79, stat: Journal Article,

H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions
Jin, Chunyuan; Zang, Chongzhi; Wei, Gang; Cui, Kairong; Peng, Weiqun; Zhao, Keji; Felsenfeld, Gary
2009 Aug;41(8):941-945, Nature genetics
— id: 114465, year: 2009, vol: 41, page: 941, stat: Journal Article,

Nucleosome stability mediated by histone variants H3.3 and H2A.Z
Jin, Chunyuan; Felsenfeld, Gary
2007 Jun 15;21(12):1519-1529, Genes & development
— id: 114466, year: 2007, vol: 21, page: 1519, stat: Journal Article,

Distribution of histone H3.3 in hematopoietic cell lineages
Jin, Chunyuan; Felsenfeld, Gary
2006 Jan 17;103(3):574-579, Proceedings of the National Academy of Sciences of the United States of America
— id: 114468, year: 2006, vol: 103, page: 574, stat: Journal Article,

Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2
Jin, Chunyuan; Kato, Kohsuke; Chimura, Takahiko; Yamasaki, Takahito; Nakade, Koji; Murata, Takehide; Li, Hongjie; Pan, Jianzhi; Zhao, Mujun; Sun, Kailai; Chiu, Robert; Ito, Takashi; Nagata, Kyosuke; Horikoshi, Masami; Yokoyama, Kazunari K
2006 Apr;13(4):331-338, Nature structural & molecular biology
— id: 114467, year: 2006, vol: 13, page: 331, stat: Journal Article,

Chromatin boundaries and chromatin domains
Felsenfeld, G; Burgess-Beusse, B; Farrell, C; Gaszner, M; Ghirlando, R; Huang, S; Jin, C; Litt, M; Magdinier, F; Mutskov, V; Nakatani, Y; Tagami, H; West, A; Yusufzai, T
2004 ;69:245-250, Cold Spring Harbor symposia on quantitative biology
— id: 114606, year: 2004, vol: 69, page: 245, stat: Journal Article,

Histone modification activities of JDP2 associated with retinoic acid-induced differentiation of F9 cells
Pan, Jianzhi; Jin, Chuyuan; Murata, Takehide; Yokoyama, Kazunari K
2004 ;(48):189-190, Nucleic acids symposium series (2004)
— id: 114605, year: 2004, vol: , page: 189, stat: Journal Article,

Role of histone acetyltransferase and deacetylase in the retinoic acid-induced differentiation of F9 cells
Jin, CY; Li, HG; Horikoshi, M; Sun, KL; Yokoyama, KK
2003 ;851:163-176, ACS symposium series
— id: 114612, year: 2003, vol: 851, page: 163, stat: Journal Article,

Sequence specific transcription factor, JDP2 interacts with histone and inhibits p300-mediated histone acetylation
Pan, Jianzhi; Jin, Chunyuan; Murata, Takehide; Yokoyama, Kazunari K
2003 ;(3):305-306, Nucleic acids research. Supplement (2001)
— id: 114469, year: 2003, vol: , page: 305, stat: Journal Article,

JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells
Jin, Chunyuan; Li, Hongjie; Murata, Takehide; Sun, Kailai; Horikoshi, Masami; Chiu, Robert; Yokoyama, Kazunari K
2002 Jul;22(13):4815-4826, Molecular & cellular biology
— id: 114471, year: 2002, vol: 22, page: 4815, stat: Journal Article,

Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells
Jin, Chunyuan; Li, Hongjie; Ugai, Hideyo; Murata, Takehide; Yokoyama, Kazunari K
2002 ;(2):97-98, Nucleic acids research. Supplement (2001)
— id: 114470, year: 2002, vol: , page: 97, stat: Journal Article,

Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2
Jin, C; Ugai, H; Song, J; Murata, T; Nili, F; Sun, K; Horikoshi, M; Yokoyama, K K
2001 Jan 26;489(1):34-41, FEBS letters
— id: 114611, year: 2001, vol: 489, page: 34, stat: Journal Article,

Transcriptional regulation of interferon gamma gene by p300 co-activator
Nakayama, A; Kawasaki, H; Jin, C; Munekata, E; Taira, K; Yokoyama, K K
2001 ;(1):89-90, Nucleic acids research. Supplement (2001)
— id: 114610, year: 2001, vol: , page: 89, stat: Journal Article,

Mannosylerythritol lipid induces characteristics of neuronal differentiation in PC12 cells through an ERK-related signal cascade
Wakamatsu, Y; Zhao, X; Jin, C; Day, N; Shibahara, M; Nomura, N; Nakahara, T; Murata, T; Yokoyama, K K
2001 Jan;268(2):374-383, European journal of biochemistry
— id: 114609, year: 2001, vol: 268, page: 374, stat: Journal Article,

Mannosylerythritol lipid increases levels of galactoceramide in and neurite outgrowth from PC12 pheochromocytoma cells
Shibahara, M; Zhao, X; Wakamatsu, Y; Nomura, N; Nakahara, T; Jin, C; Nagaso, H; Murata, T; Yokoyama, K K
2000 Jul;33(1-3):247-251, Cytotechnology
— id: 114608, year: 2000, vol: 33, page: 247, stat: Journal Article,

Induction of the differentiation of human HL-60 promyelocytic leukemia cell line by succinoyl trehalose lipids
Sudo, T; Zhao, X; Wakamatsu, Y; Shibahara, M; Nomura, N; Nakahara, T; Suzuki, A; Kobayashi, Y; Jin, C; Murata, T; Yokoyama, K K
2000 Jul;33(1-3):259-264, Cytotechnology
— id: 114607, year: 2000, vol: 33, page: 259, stat: Journal Article,