Chunyuan Jin

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Chunyuan Jin

Assistant Professor, Department of Environmental Medicine;Assistant Professor, Department of Biochemistry and Molecular Pharmacology
Environmental Medicine

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845/731-3602
Chunyuan.Jin@nyumc.org

Research Summary

In eukaryotic cells, DNA is packaged into a DNA-protein complex called chromatin. The fundamental subunit of chromatin is the nucleosome core particle, which consists of 147 base pairs of DNA wrapped around a histone octamer. Chromatin structure regulates the access of regulatory factors to the genomic DNA and thus exerts a profound control over most DNA-templated processes such as transcription, DNA repair and replication. Elucidating the interaction between chromatin structure and these nuclear processes is critical for understanding of development and human disease. Chromatin structure can be altered by several epigenetic mechanisms including DNA methylation, post-translational histone modifications, and the assembly of variant histones into chromatin. Our research focuses on how epigenetic mechanisms, in particular the incorporation of histone variants into nucleosome, modulate chromatin structure and gene expression. Another focus in our laboratory involves understanding the mechanisms of both assembly/disassembly and replication of nucleosomes containing histone variant(s). We are also interested in the mechanisms by which environmental factors influence epigenetic profiles of normal cells and contribute to carcinogenesis.

Research Interests

Chromatin structure, epigenetic mechanisms, histone variants, gene expression, carcinogenesis

A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA
Brocato, Jason; Chen, Danqi; Liu, Jianli; Fang, Lei; Jin, Chunyuan; Costa, Max
2015-05-23; 1559-0720,Biological trace element research - id: 1587302, year: 2015 JOURNAL ARTICLE

Arsenic epigenetically regulates SLBP which leads to aberrant polyadenylation of h3.1 mRNA that remains present outside of s phase
Brocato, J A; Chervona, Y; Jin, C; Costa, M
2014-10-09; 0893-6692,Environmental & molecular mutagenesis - id: 1291782, year: 2014

Arsenic induces polyadenylation of canonical histone mRNA by downregulating stem-loop binding protein gene expression
Brocato, Jason; Fang, Lei; Chervona, Yana; Chen, Danqi; Kiok, Kathrin; Sun, Hong; Tseng, Hsiang-Chi; Xu, Dazhong; Shamy, Magdy; Jin, Chunyuan; Costa, Max
2014-10-05; 0021-9258,Journal of biological chemistry - id: 1282832, year: 2014 JOURNAL ARTICLE

Environmental stress-induced Chromatin Regulation and its Heritability
Fang, Lei; Wuptra, Kenly; Chen, Danqi; Li, Hongjie; Huang, Shau-Ku; Jin, Chunyuan; Yokoyama, Kazunari K
2014-02-27; 2157-2518,Journal of carcinogenesis & mutagenesis - id: 816312, year: 2014

Bovine Induced Pluripotent Stem Cells Are More Resistant to Apoptosis than Testicular Cells in Response to Mono-(2-ethylhexyl) Phthalate
Lin, Ying-Chu; Kuo, Kung-Kai; Wuputra, Kenly; Lin, Shih-Han; Ku, Chia-Chen; Yang, Ya-Han; Wang, Shin-Wei; Wang, Sheng-Wen; Wu, Deng-Chyang; Wu, Chun-Chien; Chai, Chee-Yin; Lin, Cheng-Lung; Lin, Chang-Shen; Kajitani, Masayuki; Miyoshi, Hiroyuki; Nakamura, Yukio; Hashimoto, Shinichi; Matsushima, Kouji; Jin, Chunyuan; Huang, Shau-Ku; Saito, Shigeo; Yokoyama, Kazunari K
2014-03-31; 1422-0067,International journal of molecular sciences - id: 863272, year: 2014 Journal Article