Biosketch / Results /

Ivan Kirov

Assistant Professor, Department of Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212-263-3337
Ivan.Kirov@nyumc.org

Research Summary

In the clinic, neurologists often encounter patients whose symptoms are not explained by their magnetic resonance imaging (MRI) exam. Such discordance between clinical and radiological findings is explained by the fact that a routine MRI does not reflect all aspects of brain health. For example, tissue which looks normal on MRI can have chemical imbalances that can be responsible for current symptoms or future disease. One way to image such biochemical or metabolic changes is through a technique called magnetic resonance spectroscopy (MRS). My research focuses on its use in neurological disorders, particularly in concussion/traumatic brain injury (TBI) and multiple sclerosis. My work is done through departmental, institutional and international collaborations with physicians, physicists and other scientists, and currently includes the following four areas of investigation.

My main current project, funded by the R01 mechanism of the National Institutes of Health (NIH), is entitled “Quantitative sodium MR imaging and proton MR spectroscopy in traumatic brain injury” and is headed by me and my colleague Guillaume Madelin as co-Principal Investigators. The goal is to investigate the use of multimodal MRI and MRS for the prediction of long term TBI outcome.

As part of the NYU Langone team, I am involved in a multisite study on the effects of repetitive TBI in athletes. The NIH-funded project, “Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, And Risk Factors”, is led by Boston University and aims to develop methods for early detection and diagnosis of neurodegenerative pathology associated in part with repetitive TBI.

In multiple sclerosis, my goal has been to characterize the temporal evolution of the metabolic changes taking place in early disease (within ~5 years of onset). This work is done in collaboration with my colleague Oded Gonen.

Through a grant awarded by the Alzheimer’s Disease Center at NYU Langone, I study pre-clinical Alzheimer's Disease, in order to identify novel MRS markers and approaches, which can ultimately be used to improve the utility of imaging in the prediction and management of the disease.

Research Keywords

Brain imaging, Neuroscience, Spectroscopy, Metabolic imaging, Traumatic brain injury, Multiple sclerosis, Alzheimer's disease

When are metabolic ratios superior to absolute quantification? A statistical analysis
Hoch, Sarah E; Kirov, Ivan I; Tal, Assaf. When are metabolic ratios superior to absolute quantification? A statistical analysis. NMR in biomedicine. 2017 Mar 8;:?-? (2477112)

Quantifying Global-Brain Metabolite Level Changes with Whole-Head Proton MR Spectroscopy at 3T
Davitz, Matthew S; Wu, William E; Soher, Brian J; Babb, James S; Kirov, Ivan I; Huang, Jeffrey; Fatterpekar, Girish; Gonen, Oded. Quantifying Global-Brain Metabolite Level Changes with Whole-Head Proton MR Spectroscopy at 3T. Magnetic resonance imaging. 2017 Jan;35:15-19 (2232542)

New rapid, accurate T2 quantification detects pathology in normal-appearing brain regions of relapsing-remitting MS patients
Shepherd, Timothy M; Kirov, Ivan I; Charlson, Erik; Bruno, Mary; Babb, James; Sodickson, Daniel K; Ben-Eliezer, Noam. New rapid, accurate T2 quantification detects pathology in normal-appearing brain regions of relapsing-remitting MS patients. NeuroImage: Clinical. 2017 ;14:363-370 (2471012)

Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T
Meyer, E J; Kirov, I I; Tal, A; Davitz, M S; Babb, J S; Lazar, M; Malaspina, D; Gonen, O. Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T. AJNR. American journal of neuroradiology. 2016 Jul 21;37(12):2273-2279 (2185592)

MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update
Wu, Xin; Kirov, Ivan I; Gonen, Oded; Ge, Yulin; Grossman, Robert I; Lui, Yvonne W. MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update. Radiology. 2016 Jun;279(3):693-707 (2111672)