Stevan R Hubbard

Biosketch / Results /

Stevan R Hubbard, Ph.D.

Professor; Coord Structural Biology Program
Department of Biochemistry and Molecular Pharmacology and Structural Biology

Contact Info

Address

Floor 6 Room 6G
Greenberg Hall
New York, NY 10016

212-263-8938
Stevan.Hubbard@med.nyu.edu


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Education

1988 — Dr. Hubbard obtained his Ph.D. in Applied Physics from Stanford University, Graduate Education
— Dr. Hubbard was a Postdoctoral Research Scientist in the Department of Biochemistry and Molecular Biophysics, Columbia University, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

IRAK4 Activation: A Cautious Embrace
Hubbard, Stevan R
2014 Sep;55(6):805-806, Molecular cell
— id: 1252412, year: 2014, vol: 55, page: 805, stat: Journal Article,

A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity
Logue, Eric C; Bloch, Nicolin; Dhuey, Erica; Zhang, Ruonan; Cao, Ping; Herate, Cecile; Chauveau, Lise; Hubbard, Stevan R; Landau, Nathaniel R
2014 ;9(5):e97062-e97062 e97062, PLoS one
— id: 996992, year: 2014, vol: 9, page: e97062, stat: Journal Article,

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
Shan, Yibing; Gnanasambandan, Kavitha; Ungureanu, Daniela; Kim, Eric T; Hammaren, Henrik; Yamashita, Kazuo; Silvennoinen, Olli; Shaw, David E; Hubbard, Stevan R
2014 Jul;21(7):579-584, Nature structural & molecular biology
— id: 1102862, year: 2014, vol: 21, page: 579, stat: Journal Article,

Structural biology: Insulin meets its receptor
Hubbard, Stevan R
2013 Jan;493(7431):171-172, Nature
— id: 216572, year: 2013, vol: 493, page: 171, stat: Journal Article,

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase
Hubbard, Stevan R
2013 ;5(3):1-7, Cold Spring Harbor perspectives in biology
— id: 231352, year: 2013, vol: 5, page: 1, stat: Journal Article,

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation
Hubbard, Stevan R; Gnanasambandan, Kavitha
2013 Oct;1834(10):2166-2169, Biochimica & biophysica acta
— id: 541702, year: 2013, vol: 1834, page: 2166, stat: Journal Article,

Structural basis for the interaction of the adaptor protein grb14 with activated ras
Qamra, Rohini; Hubbard, Stevan R
2013 ;8(8):e72473-e72473 e72473, PLoS one
— id: 503702, year: 2013, vol: 8, page: e72473, stat: Journal Article,

New insights into the structure and function of the pseudokinase domain in JAK2
Silvennoinen, Olli; Ungureanu, Daniela; Niranjan, Yashavanthi; Hammaren, Henrik; Bandaranayake, Rajintha; Hubbard, Stevan R
2013 Aug;41(4):1002-1007, Transactions (Biochemical Society (Great Britain))
— id: 490232, year: 2013, vol: 41, page: 1002, stat: Journal Article,

The RA and PH domains of RIAM act as a proximity detector for Rap1 and PI(4,5)P-2
Wynne, J. ; Wu, J. ; Su, W. ; Hubbard, S. R. ; Philips, M. R.
2013 JUL;280 1 1(SI):400-400, FEBS journal
— id: 657892, year: 2013, vol: 280 1 1, page: 400, stat: Journal Article,

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
Bandaranayake, Rajintha M; Ungureanu, Daniela; Shan, Yibing; Shaw, David E; Silvennoinen, Olli; Hubbard, Stevan R
2012 Aug;19(8):754-759, Nature structural & molecular biology
— id: 174351, year: 2012, vol: 19, page: 754, stat: Journal Article,

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
Wynne, Joseph P; Wu, Jinhua; Su, Wenjuan; Mor, Adam; Patsoukis, Nikolaos; Boussiotis, Vassiliki A; Hubbard, Stevan R; Philips, Mark R
2012 Oct;199(2):317-330, Journal of cell biology
— id: 180090, year: 2012, vol: 199, page: 317, stat: Journal Article,

Cytokine signaling exposed
Hubbard, Stevan R
2011 Jan 12;19(1):1-2, Structure
— id: 119236, year: 2011, vol: 19, page: 1, stat: Journal Article,

Structure-guided identification of a laminin binding site on the laminin receptor precursor
Jamieson, Kelly V; Hubbard, Stevan R; Meruelo, Daniel
2011 Jan 7;405(1):24-32, Journal of molecular biology
— id: 116207, year: 2011, vol: 405, page: 24, stat: Journal Article,

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
Ungureanu, Daniela; Wu, Jinhua; Pekkala, Tuija; Niranjan, Yashavanthi; Young, Clifford; Jensen, Ole N; Xu, Chong-Feng; Neubert, Thomas A; Skoda, Radek C; Hubbard, Stevan R; Silvennoinen, Olli
2011 ;18(9):971-976, Nature structural & molecular biology
— id: 137017, year: 2011, vol: 18, page: 971, stat: Journal Article,

Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)
Zhang, Wei; Coldefy, Anne-Sophie; Hubbard, Stevan R; Burden, Steven J
2011 Nov 25;286(47):40624-40630, Journal of biological chemistry
— id: 150244, year: 2011, vol: 286, page: 40624, stat: Journal Article,

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization
Bergamin, Elisa; Hallock, Peter T; Burden, Steven J; Hubbard, Stevan R
2010 Jul 9;39(1):100-109, Molecular cell
— id: 110694, year: 2010, vol: 39, page: 100, stat: Journal Article,

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis
Cerda-Maira, Francisca A; Pearce, Michael J; Fuortes, Michele; Bishai, William R; Hubbard, Stevan R; Darwin, K Heran
2010 Sep;77(5):1123-1135, Molecular microbiology
— id: 114585, year: 2010, vol: 77, page: 1123, stat: Journal Article,

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
Depetris, Rafael S; Wu, Jinhua; Hubbard, Stevan R
2009 Aug;16(8):833-839, Nature structural & molecular biology
— id: 101332, year: 2009, vol: 16, page: 833, stat: Journal Article,

The juxtamembrane region of EGFR takes center stage
Hubbard, Stevan R
2009 Jun 26;137(7):1181-1183, Cell
— id: 100621, year: 2009, vol: 137, page: 1181, stat: Journal Article,

Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK
Stiegler, Amy L; Burden, Steven J; Hubbard, Stevan R
2009 Oct 16;393(1):1-9, Journal of molecular biology
— id: 102933, year: 2009, vol: 393, page: 1, stat: Journal Article,

Crystal structure of the human laminin receptor precursor
Jamieson, Kelly V; Wu, Jinhua; Hubbard, Stevan R; Meruelo, Daniel
2008 Feb 8;283(6):3002-3005, Journal of biological chemistry
— id: 76763, year: 2008, vol: 283, page: 3002, stat: Journal Article,

Lrp4 is a receptor for Agrin and forms a complex with MuSK
Kim, Natalie; Stiegler, Amy L; Cameron, Thomas O; Hallock, Peter T; Gomez, Andrea M; Huang, Julie H; Hubbard, Stevan R; Dustin, Michael L; Burden, Steven J
2008 Oct 17;135(2):334-342, Cell
— id: 93378, year: 2008, vol: 135, page: 334, stat: Journal Article,

How IRE1 reacts to ER stress
Ron, David; Hubbard, Stevan R
2008 Jan 11;132(1):24-26, Cell
— id: 76457, year: 2008, vol: 132, page: 24, stat: Journal Article,

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Wu, Jinhua; Li, Wanqing; Craddock, Barbara P; Foreman, Kenneth W; Mulvihill, Mark J; Ji, Qun-sheng; Miller, W Todd; Hubbard, Stevan R
2008 Jul 23;27(14):1985-1994, EMBO journal
— id: 80313, year: 2008, vol: 27, page: 1985, stat: Journal Article,

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
Wu, Jinhua; Tseng, Yolanda D; Xu, Chong-Feng; Neubert, Thomas A; White, Morris F; Hubbard, Stevan R
2008 Mar;15(3):251-258, Nature structural & molecular biology
— id: 76468, year: 2008, vol: 15, page: 251, stat: Journal Article,

Receptor tyrosine kinases: mechanisms of activation and signaling
Hubbard, Stevan R; Miller, W Todd
2007 Apr;19(2):117-123, Current opinion in cell biology
— id: 72808, year: 2007, vol: 19, page: 117, stat: Journal Article,

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3
Bergamin, Elisa; Wu, Jinhua; Hubbard, Stevan R
2006 Aug;14(8):1285-1292, Structure
— id: 68986, year: 2006, vol: 14, page: 1285, stat: Journal Article,

Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS
Hu, Junjie; Hubbard, Stevan R
2006 Aug 4;361(1):69-79, Journal of molecular biology
— id: 65226, year: 2006, vol: 361, page: 69, stat: Journal Article,

EGF receptor activation: push comes to shove
Hubbard, Stevan R
2006 Jun 16;125(6):1029-1031, Cell
— id: 65227, year: 2006, vol: 125, page: 1029, stat: Journal Article,

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK
Stiegler, Amy L; Burden, Steven J; Hubbard, Stevan R
2006 Dec 1;364(3):424-433, Journal of molecular biology
— id: 70021, year: 2006, vol: 364, page: 424, stat: Journal Article,

Structural basis for inhibition of the insulin receptor by the adaptor protein grb14
Depetris, Rafael S; Hu, Junjie; Gimpelevich, Ilana; Holt, Lowenna J; Daly, Roger J; Hubbard, Stevan R
2005 Oct 28;20(2):325-333, Molecular cell
— id: 58752, year: 2005, vol: 20, page: 325, stat: Journal Article,

Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design
Hines, Aliya C; Parang, Keykavous; Kohanski, Ronald A; Hubbard, Stevan R; Cole, Philip A
2005 Aug;33(4):285-297, Bioorganic chemistry
— id: 65228, year: 2005, vol: 33, page: 285, stat: Journal Article,

Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
Hu, Junjie; Hubbard, Stevan R
2005 May 13;280(19):18943-18949, Journal of biological chemistry
— id: 52545, year: 2005, vol: 280, page: 18943, stat: Journal Article,

EGF receptor inhibition: attacks on multiple fronts
Hubbard, Stevan R
2005 Apr;7(4):287-288, Cancer cell
— id: 52544, year: 2005, vol: 7, page: 287, stat: Journal Article,

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase
Li, Shiqing; Depetris, Rafael S; Barford, David; Chernoff, Jonathan; Hubbard, Stevan R
2005 Nov;13(11):1643-1651, Structure
— id: 62350, year: 2005, vol: 13, page: 1643, stat: Journal Article,

Juxtamembrane autoinhibition in receptor tyrosine kinases
Hubbard, Stevan R
2004 Jun;5(6):464-471, Nature reviews. Molecular cell biology
— id: 43031, year: 2004, vol: 5, page: 464, stat: Journal Article,

Oncogenic mutations in B-Raf: some losses yield gains
Hubbard, Stevan R
2004 Mar 19;116(6):764-766, Cell
— id: 43032, year: 2004, vol: 116, page: 764, stat: Journal Article,

Agrin/MuSK signaling: willing and Abl
Burden, Steven J; Fuhrer, Christian; Hubbard, Stevan R
2003 Jul;6(7):653-654, Nature neuroscience
— id: 65229, year: 2003, vol: 6, page: 653, stat: Journal Article,

Structural Basis for Recruitment of the Adaptor Protein APS to the Activated Insulin Receptor
Hu, Junjie; Liu, Jun; Ghirlando, Rodolfo; Saltiel, Alan R; Hubbard, Stevan R
2003 Dec;12(6):1379-1389, Molecular cell
— id: 40090, year: 2003, vol: 12, page: 1379, stat: Journal Article,

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor
Li, Shiqing; Covino, Nicole D; Stein, Evan G; Till, Jeffrey H; Hubbard, Stevan R
2003 Jul 11;278(28):26007-26014, Journal of biological chemistry
— id: 39243, year: 2003, vol: 278, page: 26007, stat: Journal Article,

Structural Basis for Dimerization of the Grb10 Src Homology 2 Domain. IMPLICATIONS FOR LIGAND SPECIFICITY
Stein, Evan G; Ghirlando, Rodolfo; Hubbard, Stevan R
2003 Apr 11;278(15):13257-13264, Journal of biological chemistry
— id: 34133, year: 2003, vol: 278, page: 13257, stat: Journal Article,

Protein tyrosine kinases: autoregulation and small-molecule inhibition
Hubbard, Stevan R
2002 Dec;12(6):735-741, Current opinion in structural biology
— id: 39343, year: 2002, vol: 12, page: 735, stat: Journal Article,

Crystal Structure of the MuSK Tyrosine Kinase. Insights into Receptor Autoregulation
Till, Jeffrey H; Becerra, Manuel; Watty, Anke; Lu, Yun; Ma, Yuliang; Neubert, Thomas A; Burden, Steven J; Hubbard, Stevan R
2002 Sep;10(9):1187-1196, Structure
— id: 32906, year: 2002, vol: 10, page: 1187, stat: Journal Article,

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
Favelyukis S; Till JH; Hubbard SR; Miller WT
2001 Dec;8(12):1058-1063, Nature structural biology
— id: 24974, year: 2001, vol: 8, page: 1058, stat: Journal Article,

Theme and variations: juxtamembrane regulation of receptor protein kinases
Hubbard SR
2001 Sep;8(3):481-482, Molecular cell
— id: 24975, year: 2001, vol: 8, page: 481, stat: Journal Article,

Mechanism-based design of a protein kinase inhibitor
Parang K; Till JH; Ablooglu AJ; Kohanski RA; Hubbard SR; Cole PA
2001 Jan;8(1):37-41, Nature structural biology
— id: 20816, year: 2001, vol: 8, page: 37, stat: Journal Article,

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors
Stein EG; Gustafson TA; Hubbard SR
2001 Mar 30;493(2-3):106-111, FEBS letters
— id: 20817, year: 2001, vol: 493, page: 106, stat: Journal Article,

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism
Till JH; Ablooglu AJ; Frankel M; Bishop SM; Kohanski RA; Hubbard SR
2001 Mar 30;276(13):10049-10055, Journal of biological chemistry
— id: 20815, year: 2001, vol: 276, page: 10049, stat: Journal Article,

Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate
Ablooglu, A J; Till, J H; Kim, K; Parang, K; Cole, P A; Hubbard, S R; Kohanski, R A
2000 Sep;275(39):30394-30398, Journal of biological chemistry
— id: 163497, year: 2000, vol: 275, page: 30394, stat: Journal Article,

PROTEIN TYROSINE KINASE STRUCTURE AND FUNCTION
Hubbard SR; Till JH
2000 ;69:373-398, Annual review of biochemistry
— id: 11520, year: 2000, vol: 69, page: 373, stat: Journal Article,

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
Laird AD; Vajkoczy P; Shawver LK; Thurnher A; Liang C; Mohammadi M; Schlessinger J; Ullrich A; Hubbard SR; Blake RA; Fong TA; Strawn LM; Sun L; Tang C; Hawtin R; Tang F; Shenoy N; Hirth KP; McMahon G; Cherrington
2000 Aug 1;60(15):4152-4160, Cancer research
— id: 20814, year: 2000, vol: 60, page: 4152, stat: Journal Article,

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
Plotnikov AN; Hubbard SR; Schlessinger J; Mohammadi M
2000 May 12;101(4):413-424, Cell
— id: 11676, year: 2000, vol: 101, page: 413, stat: Journal Article,

Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases
Sun, L; Tran, N; Liang, C; Hubbard, S; Tang, F; Lipson, K; Schreck, R; Zhou, Y; McMahon, G; Tang, C
2000 Jul;43(14):2655-2663, Journal of medicinal chemistry
— id: 635162, year: 2000, vol: 43, page: 2655, stat: Journal Article,

Structural analysis of receptor tyrosine kinases
Hubbard SR
1999 ;71(3-4):343-358, Progress in biophysics & molecular biology
— id: 6129, year: 1999, vol: 71, page: 343, stat: Journal Article,

Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta
Mandiyan V; Andreev J; Schlessinger J; Hubbard SR
1999 Dec 15;18(24):6890-6898, EMBO journal
— id: 8587, year: 1999, vol: 18, page: 6890, stat: Journal Article,

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain
Nelms, K; O'Neill, T J; Li, S; Hubbard, S R; Gustafson, T A; Paul, W E
1999 Dec;10(12):1160-1167, Mammalian genome
— id: 635602, year: 1999, vol: 10, page: 1160, stat: Journal Article,

Structural basis for FGF receptor dimerization and activation
Plotnikov AN; Schlessinger J; Hubbard SR; Mohammadi M
1999 Sep 3;98(5):641-650, Cell
— id: 8352, year: 1999, vol: 98, page: 641, stat: Journal Article,

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
Mohammadi, M; Froum, S; Hamby, J M; Schroeder, M C; Panek, R L; Lu, G H; Eliseenkova, A V; Green, D; Schlessinger, J; Hubbard, S R
1998 Oct;17(20):5896-5904, EMBO journal
— id: 156649, year: 1998, vol: 17, page: 5896, stat: Journal Article,

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
Hubbard SR
1997 Sep 15;16(18):5572-5581, EMBO journal
— id: 8449, year: 1997, vol: 16, page: 5572, stat: Journal Article,

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
Mohammadi M; McMahon G; Sun L; Tang C; Hirth P; Yeh BK; Hubbard SR; Schlessinger J
1997 May 9;276(5314):955-960, Science
— id: 8448, year: 1997, vol: 276, page: 955, stat: Journal Article,

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
Mohammadi M; Schlessinger J; Hubbard SR
1996 Aug 23;86(4):577-587, Cell
— id: 7021, year: 1996, vol: 86, page: 577, stat: Journal Article,

CATALYTIC SPECIFICITY OF PROTEIN-TYROSINE KINASES IS CRITICAL FOR SELECTIVE SIGNALING
SONGYANG, Z; CARRAWAY, KL; ECK, MJ; HARRISON, SC; FELDMAN, RA; MOHAMMADI, M; SCHLESSINGER, J; HUBBARD, SR; SMITH, DP; ENG, C; LORENZO, MJ; PONDER, BAJ; MAYER, BJ; CANTLEY, LC
1995 FEB 9 ;373(6514):536-539, Nature
— id: 87442, year: 1995, vol: 373, page: 536, stat: Journal Article,