Stevan R Hubbard

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Stevan Hubbard

Professor, Department of Biochemistry and Molecular Pharmacology
Skirball Institute

Contact Info

540-562 First Avenue
New York, NY 10016



1988 — Dr. Hubbard obtained his Ph.D. in Applied Physics from Stanford University, Graduate Education
— Dr. Hubbard was a Postdoctoral Research Scientist in the Department of Biochemistry and Molecular Biophysics, Columbia University, PostDoctoral Training

Research Summary

My laboratory is interested in the molecular mechanisms by which the insulin receptor and other receptor tyrosine kinases (RTKs) are activated upon ligand binding, and the structural basis for recruitment of downstream signaling proteins to activated receptors. The main experimental technique we employ for three-dimensional structure determination is x-ray crystallography. Members of the RTK family include, among others, the insulin and insulin-like growth factor-1 (IGF1) receptors, fibroblast growth factor receptor, platelet-derived growth factor receptor, and epidermal growth factor receptor. RTKs play critical roles in signal transduction pathways that mediate cell proliferation, differentiation, migration and metabolism, both in organismal development and in adult homeostasis. RTKs have also been implicated in the onset or progression of numerous cancers. We are also studying the molecular mechanisms by which Jak2, a member of the Janus kinase family of non-receptor tyrosine kinases, is regulated. Activating mutations in Jak2 are causative for myeloproliferative neoplasms in humans.

Research Interests

Structural and Mechanistic Studies of Protein Tyrosine Kinases

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state
Cabail, M Zulema; Li, Shiqing; Lemmon, Eric; Bowen, Mark E; Hubbard, Stevan R; Miller, W Todd
2015-03-16; 2041-1723,Nature communications - id: 1495912, year: 2015 Journal Article

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
Hammaré HM; Ungureanu, D; Grisouard, J; Skoda, RC; Hubbard, SR; Silvennoinen, O
2015-06-01; 0027-8424,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 1605092, year: 2015

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
Hammaren, Henrik M; Ungureanu, Daniela; Grisouard, Jean; Skoda, Radek C; Hubbard, Stevan R; Silvennoinen, Olli
2015-04-20; 1091-6490,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 1531932, year: 2015 Journal Article

Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide
Samanovic, Marie I; Tu, Shengjiang; Novak, Ondrej; Iyer, Lakshminarayan M; McAllister, Fiona E; Aravind, L; Gygi, Steven P; Hubbard, Stevan R; Strnad, Miroslav; Darwin, K Heran
2015-04-06; 1097-4164,Molecular cell - id: 1520722, year: 2015 Journal Article

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms
Silvennoinen, Olli; Hubbard, Stevan R
2015-06-30; 1528-0020,Blood - id: 1644532, year: 2015 REVIEW