Eva M Hernando-Monge

Biosketch / Results /

Eva M Hernando-Monge, Ph.D.

Associate Professor; Vice Chair for Science; Co-Director, MSTP
Department of Pathology (Pathology)

Contact Info

Address
522 First Ave.
Dept. of Pathology Floor 3 Room 305
Smilow Research Building
NY, NY 10016

212-263-9054
Eva.Hernando-Monge@nyumc.org

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Education

1994-1999 — Universidad Autonoma Madrid, Spain, Graduate Education
2000-2006 — Memorial Sloan-Kettering Cancer Center, PostDoctoral Training

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Research Summary

Traditionally, mature cells in specific tissues and organs have been regarded as the cell-of-origin of the corresponding tumors. However, the observation that tumor cells need to accumulate genetic and phenotypic alterations over extended time periods has turned the view to stem cells or progenitors with a prolonged lifespan, which are broadly distributed in local reservoirs. These cells, in charge of maintaining tissue homeostasis, are contemplated as the target of neoplastic transformation.

Our laboratory is studying whether certain sarcomas originate from mesenchymal progenitors and whether melanomas result from transformation of melanocytic stem cells. Moreover, we hypothesize that alterations in the normal differentiation process of these progenitors act at early stages of tumor initiation, and that the retention or reactivation of stem cell properties may contribute to tumor progression and aggressive behavior (resistance to therapy, metastasis). A limitation for these studies is our partial understanding of the normal differentiation process of these two lineages.

Sarcoma studies

To overcome this limitation, our laboratory has established and characterized the in vitro differentiation of human Mesenchymal Stem Cells (hMSCs) into smooth-muscle (SMC), the lineage of origin of Leiomyosarcomas (LMS), tumors that appear in the uterus, the retroperitoneum and the extremities. We have found that some miRNAs down-regulated during hMSC differentiation are overexpressed in uterine LMS compared to normal myometrium. We are currently determining whether these candidate miRNAs play an active role in SM differentiation in vitro and in vivo and whether their alteration leads to a blockade in SM maturation, increased proliferation and/or MSC transformation.

In addition, we have developed a leiomyosarcoma mouse model based on the inactivation of Pten in an early smooth-muscle progenitor (using the transgelin promoter, Tgln). MSCs isolated from Tgln-cre/Ptenlox/lox mice are being analyzed for the effect of Pten inactivation in stem cell maintenance, proliferation and differentiation. Mice heterozygous for Pten and p53 in the SM lineage develop very aggressive LMS that are able to spontaneously metastasize to distal organs.

Melanoma studies

Melanomas also show phenotypic heterogeneity both in vivo and in vitro, suggesting an origin from a cell with multilineage differentiation abilities. Moreover, malignant melanoma seems to evoke the migratory nature of neural crest and melanoblasts from which melanocytes arise, suggesting that transformation may occur in a melanocytic stem cell.

Our lab has found that a miRNA cluster (miR-182-96-183) located in a genomic region frequently amplified in melanoma (7q31-34) is overexpressed in melanoma tissues and cell lines. A member of this cluster, miR-182, controls MITF, a transcription factor with a critical role in melanocytic differentiation. We have demonstrated that upregulation of a member of this cluster, miR-182, promotes migration in vitro and metastasis in vivo. Interestingly, miR-182 targets MITF, a master regulator of melanocytic differentiation. Ongoing work using stem cells, melanoma cell lines, and mouse models should unravel the mechanism(s) by which this miRNA contributes to melanoma progression.

Research Interests

Our lab is studying whether a developmental model of tumorigenesis can be applied to solid cancers, in particular to sarcomas and melanomas. We hypothesize that these tumors originate from stem cells or precursors retaining self-renewal capacity, whose neoplastic transformation involves a differentiation blockade. As part of these studies, we are investigating the dual role of microRNAs in differentiation and tumorigenesis.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis
Danielson, Laura S; Park, David S; Rotllan, Noemi; Chamorro-Jorganes, Aranzazu; Guijarro, Maria V; Fernandez-Hernando, Carlos; Fishman, Glenn I; Phoon, Colin K L; Hernando, Eva
2013 Apr;27(4):1460-1467, FASEB journal
— id: 271182, year: 2013, vol: 27, page: 1460, stat: Journal Article,

In vivo Modeling and Molecular Characterization: A Path Toward Targeted Therapy of Melanoma Brain Metastasis
Gaziel-Sovran, Avital; Osman, Iman; Hernando, Eva
2013 ;3:127-127, Frontiers in oncology
— id: 394062, year: 2013, vol: 3, page: 127, stat: Journal Article,

Dual pten/tp53 suppression promotes sarcoma progression by activating notch signaling
Guijarro, Maria V; Dahiya, Sonika; Danielson, Laura S; Segura, Miguel F; Vales-Lara, Frances M; Menendez, Silvia; Popiolek, Dorota; Mittal, Khushbakhat; Wei, Jian Jun; Zavadil, Jiri; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo; Hernando, Eva
2013 Jun;182(6):2015-2027, American journal of pathology
— id: 361832, year: 2013, vol: 182, page: 2015, stat: Journal Article,

FBH1 protects melanocytes from transformation and is deregulated in melanomas
Jeong, Yeon-Tae; Cermak, Lukas; Guijarro, Maria V; Hernando, Eva; Pagano, Michele
2013 Apr;12(7):1128-1132, Cell cycle
— id: 287222, year: 2013, vol: 12, page: 1128, stat: Journal Article,

Development and characterization of a clinically relevant mouse model of melanoma brain metastasis
Morsi, Amr; Gaziel-Sovran, Avital; Cruz-Munoz, William; Kerbel, Robert S; Golfinos, John G; Hernando, Eva; Wadghiri, Youssef Z
2013 Sep;26(5):743-745, Pigment cell & melanoma research
— id: 512832, year: 2013, vol: 26, page: 743, stat: Journal Article,

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo
O'Reilly, Kathryn E; de Miera, Eleazar Vega-Saenz; Segura, Miguel F; Friedman, Erica; Poliseno, Laura; Han, Sung Won; Zhong, Judy; Zavadil, Jiri; Pavlick, Anna; Hernando, Eva; Osman, Iman
2013 ;6(11):1429-1450, Pharmaceuticals
— id: 688062, year: 2013, vol: 6, page: 1429, stat: Journal Article,

Targeting BET proteins in melanoma: A novel treatment approach
Paoluzzi, L; Segura, M F; Fontanals-Cirera, B; Gaziel-Sovran, A; Guijarro, M V; Hanniford, D; Gonzales-Gomez, P; Zhang, W; Zhang, G; Darvishian, F; Ohlmeyer, M; Osman, I; Zhou, M -M; Hernando, E
2013 20 May 2013;31(15):-, Journal of clinical oncology
— id: 451862, year: 2013, vol: 31, page: , stat: Journal Article,

Inactivation of patched1 in mice leads to development of gastrointestinal stromal-like tumors that express pdgfralpha but not kit
Pelczar, Penelope; Zibat, Arne; van Dop, Willemijn A; Heijmans, Jarom; Bleckmann, Annalen; Gruber, Wolfgang; Nitzki, Frauke; Uhmann, Anja; Guijarro, Maria V; Hernando, Eva; Dittmann, Kai; Wienands, Jurgen; Dressel, Ralf; Wojnowski, Leszek; Binder, Claudia; Taguchi, Takahiro; Beissbarth, Tim; Hogendoorn, Pancras C W; Antonescu, Cristina R; Rubin, Brian P; Schulz-Schaeffer, Walter; Aberger, Fritz; van den Brink, Gijs R; Hahn, Heidi
2013 Jan;144(1):134-144.e6, Gastroenterology
— id: 209552, year: 2013, vol: 144, page: 134, stat: Journal Article,

Clinicopathological characteristics at primary melanoma diagnosis as risk factors for brain metastasis
Qian, Meng; Ma, Michelle W; Fleming, Nathaniel H; Lackaye, Daniel J; Hernando, Eva; Osman, Iman; Shao, Yongzhao
2013 Dec;23(6):461-467, Melanoma research
— id: 598572, year: 2013, vol: 23, page: 461, stat: Journal Article,

BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy
Segura, Miguel F; Fontanals-Cirera, Barbara; Gaziel-Sovran, Avital; Guijarro, Maria V; Hanniford, Doug; Zhang, Guangtao; Gonzalez-Gomez, Pilar; Morante, Marta; Jubierre, Luz; Zhang, Weijia; Darvishian, Farbod; Ohlmeyer, Michael; Osman, Iman; Zhou, Ming-Ming; Hernando, Eva
2013 Oct;73(20):6264-6276, Cancer research
— id: 573772, year: 2013, vol: 73, page: 6264, stat: Journal Article,

Melanoma recurrence risk stratification using Bayesian systems biology modeling
Styrmisdottir, E L; Scanlon, P; Hanniford, D; Eberhardt, J; Jones, T; Hernando, E; Osman, I
2013 20 May 2013;31(15):-, Journal of clinical oncology
— id: 451872, year: 2013, vol: 31, page: , stat: Journal Article,

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells
Alvarez-Diaz, Silvia; Valle, Noelia; Ferrer-Mayorga, Gemma; Lombardia, Luis; Herrera, Mercedes; Dominguez, Orlando; Segura, Miguel F; Bonilla, Felix; Hernando, Eva; Munoz, Alberto
2012 May;21(10):2157-2165, Human molecular genetics
— id: 166876, year: 2012, vol: 21, page: 2157, stat: Journal Article,

HYPOXIA UPREGULATES MIR-451 EXPRESSION IN GLIOMAS
Esencay, Mine; Gonzalez, Pilar; Gaziel, Avital; Safraz, Yasmeen; Mira, Helena; Hernando, Eva; Zagzag, David
2012 OCT;14 6 6:2-2, Neuro-oncology
— id: 205022, year: 2012, vol: 14 6 6, page: 2, stat: Journal Article,

MicroRNA-22 mediates partially the effects of Vitamin D3 in colon cancer
Ferrer-Mayorga, G.; Alvarez-Diaz, S.; Valle, N.; Lombardia, L.; Herrera, M.; Domiguez, O.; Segura, M. F.; Bonilla, F.; Hernando, E.; Munoz, A.
2012 SEP;279 1 1(SI):479-480, FEBS journal
— id: 178300, year: 2012, vol: 279 1 1, page: 479, stat: Journal Article,

Identification of melanoma-specific alterations in cell surface glycosylation
Friedman, E B; Rakus, J F; Zavadil, J; Hernando, E; Mahal, L K; Osman, I
2012 20 May 2012;30(15):-, Journal of clinical oncology
— id: 249872, year: 2012, vol: 30, page: , stat: Journal Article,

Serum microRNAs as biomarkers for recurrence in melanoma
Friedman, Erica B; Shang, Shulian; de Miera, Eleazar Vega-Saenz; Fog, Jacob Ulrik; Teilum, Maria Wrang; Ma, Michelle W; Berman, Russell S; Shapiro, Richard L; Pavlick, Anna C; Hernando, Eva; Baker, Adam; Shao, Yongzhao; Osman, Iman
2012 ;10:155-155, Journal of translational medicine
— id: 180442, year: 2012, vol: 10, page: 155, stat: Journal Article,

Expression of miR-16 is not a suitable reference for analysis of serum microRNAs in melanoma patients
Friedman, Erica B; Shang, Shulian; Fleming, Nathaniel H; Vega-Saenz De Miera, Eleazar; Hernando, Eva; Shao, Yongzhao; Osman, Iman
2012 ;5:647-651, Journal of biomedical science & engineering
— id: 347512, year: 2012, vol: 5, page: 647, stat: Journal Article,

miRNA-mediated GALNT modulation of invasion and immune suppression: A sweet deal for metastatic cells
Gaziel-Sovran, Avital; Hernando, Eva
2012 Aug;1(5):746-748, Oncoimmunology
— id: 221102, year: 2012, vol: 1, page: 746, stat: Journal Article,

Early alterations of microRNA expression to predict and modulate melanoma metastasis
Hernando, E; Hanniford, D; Shang, S; Segura, M F; Pavlick, A C; Berman, R S; Shapiro, R L; Darvishian, F; Osman, I; Shao, Y
2012 20 May 2012;30(15):-, Journal of clinical oncology
— id: 250022, year: 2012, vol: 30, page: , stat: Journal Article,

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma
Liu, Z; Liu, J; Segura, MF; Shao, C; Lee, P; Gong, Y; Hernando, E; Wei, JJ
2012 Feb;:204-215, Journal of pathology
— id: 164477, year: 2012, vol: , page: 204, stat: Journal Article,

MicroRNA alterations associated with BRAF status in melanoma
Ma, M W; Farhadian, J A; Friedman, E B; De, Miera E V -S; Hanniford, D; Segura, M F; Berman, R S; Shapiro, R L; Pavlick, A C; Zavadil, J; Hernando, E; Osman, I
2012 20 May 2012;30(15):-, Journal of clinical oncology
— id: 250002, year: 2012, vol: 30, page: , stat: Journal Article,

Challenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site
Ma, Michelle W; Qian, Meng; Lackaye, Daniel J; Berman, Russell S; Shapiro, Richard L; Pavlick, Anna C; Golfinos, John G; Parker, Erik C; Darvishian, Farbod; Hernando, Eva; Shao, Yongzhao; Osman, Iman
2012 Jul;14(7):849-858, Neuro-oncology
— id: 169477, year: 2012, vol: 14, page: 849, stat: Journal Article,

Newmouse models of melanoma metastasis and differences in brain tropism and metastatic growth pattern
Morsi, A M; Avital, G -S; Baig, H; Kerbel, R S; Golfinos, J; Wadghiri, Y Z; Hernando, E
2012 20 May 2012;30(15):-, Journal of clinical oncology
— id: 249882, year: 2012, vol: 30, page: , stat: Journal Article,

Targeting embryonic signaling pathways in melanoma
OReilly, K E; Poliseno, L; De, Miera E V -S; Friedman, E; Hernando, E; Osman, I
2012 15 Apr 2012;72(8):-, Cancer research
— id: 422452, year: 2012, vol: 72, page: , stat: Journal Article,

Histology-Specific MicroRNA Alterations in Melanoma
Poliseno, Laura; Haimovic, Adele; Segura, Miguel F; Hanniford, Douglas; Christos, Paul J; Darvishian, Farbod; Wang, Jinhua; Shapiro, Richard L; Pavlick, Anna C; Berman, Russell S; Hernando, Eva; Zavadil, Jiri; Osman, Iman
2012 Jul;132(7):1860-1868, Journal of investigative dermatology
— id: 169476, year: 2012, vol: 132, page: 1860, stat: Journal Article,

BRD4 is a novel therapeutic target in melanoma
Segura, M F; Di, Micco R; Zhang, G; Zhang, W; Osman, I; Zhou, M -M; Hernando, E
2012 15 Apr 2012;72(8):-, Cancer research
— id: 422432, year: 2012, vol: 72, page: , stat: Journal Article,

MicroRNA and cutaneous melanoma: from discovery to prognosis and therapy
Segura, Miguel F; Greenwald, Holly S; Hanniford, Doug; Osman, Iman; Hernando, Eva
2012 Oct;33(10):1823-1832, Carcinogenesis
— id: 182332, year: 2012, vol: 33, page: 1823, stat: Journal Article,

Unraveling the roles of the histone variant H2A.Z in melanoma progression
Vardabasso, C; Panda, T; Straub, T; Boenisch, C; Montagna, C; Verma, A; Kapoor, A; Segura, M; Duarte, L F; Hernando, E; Bhardwaj, N; Osman, I; Sosman, J A; Hake, S B; Bernstein, E
2012 November 2012;25(6):894-894, Pigment cell & melanoma research
— id: 241402, year: 2012, vol: 25, page: 894, stat: Journal Article,

miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis
Gaziel-Sovran, Avital; Segura, Miguel F; Di Micco, Raffaella; Collins, Mary K; Hanniford, Douglas; Vega-Saenz de Miera, Eleazar; Rakus, John F; Dankert, John F; Shang, Shulian; Kerbel, Robert S; Bhardwaj, Nina; Shao, Yongzhao; Darvishian, Farbod; Zavadil, Jiri; Erlebacher, Adrian; Mahal, Lara K; Osman, Iman; Hernando, Eva
2011 Jul 12;20(1):104-118, Cancer cell
— id: 135264, year: 2011, vol: 20, page: 104, stat: Journal Article,

Efficient in vivo microRNA targeting of liver metastasis
Huynh, C; Segura, M F; Gaziel-Sovran, A; Menendez, S; Darvishian, F; Chiriboga, L; Levin, B; Meruelo, D; Osman, I; Zavadil, J; Marcusson, E G; Hernando, E
2011 Mar 24;30(12):1481-1488, Oncogene
— id: 138159, year: 2011, vol: 30, page: 1481, stat: Journal Article,

Correction: The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma
Huynh, Chanh; Poliseno, Laura; Segura, Miguel F; Medicherla, Ratna; Haimovic, Adele; Menendez, Silvia; Shang, Shulian; Pavlick, Anna; Shao, Yongzhao; Darvishian, Farbod; Boylan, John F; Osman, Iman; Hernando, Eva
2011 ;6(11):?-?, PLoS one
— id: 141637, year: 2011, vol: 6, page: ?, stat: Journal Article,

The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma
Huynh, Chanh; Poliseno, Laura; Segura, Miguel F; Medicherla, Ratna; Haimovic, Adele; Menendez, Silvia; Shang, Shulian; Pavlick, Anna; Shao, Yongzhao; Darvishian, Farbod; Boylan, John F; Osman, Iman; Hernando, Eva
2011 ;6(9):e25264-e25264, PLoS one
— id: 138712, year: 2011, vol: 6, page: e25264, stat: Journal Article,

Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression
Rose AE; Poliseno L; Wang J; Clark M; Pearlman A; Wang G; Vega Y Saenz de Miera EC; Medicherla R; Christos PJ; Shapiro RL; Pavlick AC; Darvishian F; Zavadil J; Polsky D; Hernando E; Ostrer H; Osman I
2011 Apr 1;71(7):2561-2571, Cancer research
— id: 124135, year: 2011, vol: 71, page: 2561, stat: Journal Article,

Clinical relevance of SKP2 alterations in metastatic melanoma
Rose, Amy E; Wang, Guimin; Hanniford, Douglas; Monni, Stefano; Tu, Ting; Shapiro, Richard L; Berman, Russell S; Pavlick, Anna C; Pagano, Michele; Darvishian, Farbod; Mazumdar, Madhu; Hernando, Eva; Osman, Iman
2011 Feb;24(1):197-206, Pigment cell & melanoma research
— id: 138133, year: 2011, vol: 24, page: 197, stat: Journal Article,

Regulation of HMGA1 expression by microRNA296 affects prostate cancer growth and invasion
Wei JJ; Wu X; Peng Y; Shi G; Olca B; Yang X; Daniels G; Osman I; Ouyang J; Hernando E; Pellicer A; Rhim J; Melamed J; Lee P
2011 Mar 15;17(6):1297-1305, Clinical cancer research
— id: 115464, year: 2011, vol: 17, page: 1297, stat: Journal Article,

HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes
Wu, Jingjing; Liu, Zhaojian; Shao, Changshun; Gong, Yaoqin; Hernando, Eva; Lee, Peng; Narita, Masashi; Muller, William; Liu, Jinsong; Wei, Jian-Jun
2011 Jan 15;71(2):349-359, Cancer research
— id: 133176, year: 2011, vol: 71, page: 349, stat: Journal Article,

Clinical variables and primary tumor characteristics predictive of the development of melanoma brain metastases and post-brain metastases survival
Zakrzewski, Jan; Geraghty, Laurel N; Rose, Amy E; Christos, Paul J; Mazumdar, Madhu; Polsky, David; Shapiro, Richard; Berman, Russell; Darvishian, Farbod; Hernando, Eva; Pavlick, Anna; Osman, Iman
2011 Apr 15;117(8):1711-1720, Cancer
— id: 130314, year: 2011, vol: 117, page: 1711, stat: Journal Article,

A Differentiation-Based MicroRNA Signature Identifies Leiomyosarcoma as a Mesenchymal Stem Cell-Related Malignancy
Danielson, Laura S; Menendez, Silvia; Attolini, Camille Stephan-Otto; Guijarro, Maria V; Bisogna, Maria; Wei, Jianjun; Socci, Nicholas D; Levine, Douglas A; Michor, Franziska; Hernando, Eva
2010 Aug;177(2):908-917, American journal of pathology
— id: 111539, year: 2010, vol: 177, page: 908, stat: Journal Article,

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
Kapoor, Avnish; Goldberg, Matthew S; Cumberland, Lara K; Ratnakumar, Kajan; Segura, Miguel F; Emanuel, Patrick O; Menendez, Silvia; Vardabasso, Chiara; Leroy, Gary; Vidal, Claudia I; Polsky, David; Osman, Iman; Garcia, Benjamin A; Hernando, Eva; Bernstein, Emily
2010 Dec 23;468(7327):1105-1109, Nature
— id: 134348, year: 2010, vol: 468, page: 1105, stat: Journal Article,

New gamma-secretase inhibitor (RO4929097) targeting notch signaling in melanoma
Osman, I; Poliseno, L; Huynh, C T; Segura, M F; Medicherla, R; Menendez, S; Rose, A E; Pavlick, A C; Boylan, J; Hernando, E
2010 November 2010;11:61-62, Current treatment options in oncology
— id: 783372, year: 2010, vol: 11, page: 61, stat: Journal Article,

miR-7 and miR-130b are differentially regulated during Mesenchymal Stem Cell commitment
Palmer G.; Danielson L.S.; Attur M.; Abramson S.B.; Hernando E.
2010 ;62:1490-1490, Arthritis & rheumatism
— id: 130943, year: 2010, vol: 62, page: 1490, stat: Journal Article,

MIR-7 AND MIR-130B ARE DIFFERENTIALLY REGULATED DURING MESENCHYMAL STEM CELL COMMITMENT
Palmer, G.; Danielson, L.; Attur, M.; Abramson, S. B.; Hernando, E.
2010 OCT ;18(12):S39-S39, Osteoarthritis & cartilage
— id: 120554, year: 2010, vol: 18, page: S39, stat: Journal Article,

Viral oncolysis that targets Raf-1 signaling control of nuclear transport
Riolobos, Laura; Valle, Noelia; Hernando, Eva; Maroto, Beatriz; Kann, Michael; Almendral, Jose M
2010 Feb;84(4):2090-2099, Journal of virology
— id: 133458, year: 2010, vol: 84, page: 2090, stat: Journal Article,

Melanoma MicroRNA Signature Predicts Post-Recurrence Survival
Segura, Miguel F; Belitskaya-Levy, Ilana; Rose, Amy E; Zakrzewski, Jan; Gaziel, Avital; Hanniford, Douglas; Darvishian, Farbod; Berman, Russell S; Shapiro, Richard L; Pavlick, Anna C; Osman, Iman; Hernando, Eva
2010 Mar 1;16(5):1577-1586, Clinical cancer research
— id: 107357, year: 2010, vol: 16, page: 1577, stat: Journal Article,

Clinical variables and primary tumor characteristics predictive of the development of melanoma brain metastases and post-brain metastases survival
Zakrzewski J; Geraghty LN; Rose AE; Christos PJ; Mazumdar M; Polsky D; Shapiro R; Berman R; Darvishian F; Hernando E; Pavlick A; Osman I
2010 Nov 8;:?-?, Cancer
— id: 141464, year: 2010, vol: , page: ?, stat: Journal Article,

Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas
Zavadil, Jiri; Ye, Huihui; Liu, Zhaojian; Wu, JingJing; Lee, Peng; Hernando, Eva; Soteropoulos, Patricia; Toruner, Gokce A; Wei, Jian-Jun
2010 ;5(8):e12362-e12362, PLoS one
— id: 112544, year: 2010, vol: 5, page: e12362, stat: Journal Article,

A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas
Hernando, E; Sarmentero-Estrada, J; Koppie, T; Belda-Iniesta, C; Ramirez de Molina, V; Cejas, P; Ozu, C; Le, C; Sanchez, J J; Gonzalez-Baron, M; Koutcher, J; Cordon-Cardo, C; Bochner, B H; Lacal, J C; Ramirez de Molina, A
2009 Jul 2;28(26):2425-2435, Oncogene
— id: 107405, year: 2009, vol: 28, page: 2425, stat: Journal Article,

Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas
Peng, Lan; Wen, Yong; Han, Yulong; Wei, Anran; Shi, Guizhi; Mizuguchi, Masashi; Lee, Peng; Hernando, Eva; Mittal, Khush; Wei, Jian-Jun
2009 Jun;91(6):2664-2675, Fertility & sterility
— id: 78574, year: 2009, vol: 91, page: 2664, stat: Journal Article,

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Real, Pedro J; Tosello, Valeria; Palomero, Teresa; Castillo, Mireia; Hernando, Eva; de Stanchina, Elisa; Sulis, Maria Luisa; Barnes, Kelly; Sawai, Catherine; Homminga, Irene; Meijerink, Jules; Aifantis, Iannis; Basso, Giuseppe; Cordon-Cardo, Carlos; Ai, Walden; Ferrando, Adolfo
2009 Jan;15(1):50-58, Nature medicine
— id: 105355, year: 2009, vol: 15, page: 50, stat: Journal Article,

The unique molecular signatures of nodular and superficial spreading melanoma
Rose A.E.; Wang J.; Pearlman A.; Doudican N.; Hernando E.; J. Orlow S.; Polsky D.; Ostrer H.; Osman I.
2009 ;27(15 Suppl 1):9047-9047, Journal of clinical oncology
— id: 111806, year: 2009, vol: 27, page: 9047, stat: Journal Article,

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
Segura, Miguel F; Hanniford, Douglas; Menendez, Silvia; Reavie, Linsey; Zou, Xuanyi; Alvarez-Diaz, Silvia; Zakrzewski, Jan; Blochin, Elen; Rose, Amy; Bogunovic, Dusan; Polsky, David; Wei, Jianjun; Lee, Peng; Belitskaya-Levy, Ilana; Bhardwaj, Nina; Osman, Iman; Hernando, Eva
2009 Feb 10;106(6):1814-1819, Proceedings of the National Academy of Sciences of the United States of America
— id: 92154, year: 2009, vol: 106, page: 1814, stat: Journal Article,

Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
Shi, Guizhi; Perle, Mary Ann; Mittal, Khush; Chen, Hua; Zou, Xuanyi; Narita, Masashi; Hernando, Eva; Lee, Peng; Wei, Jian-Jun
2009 Sep;13(9B):3898-3905, Journal of cellular & molecular medicine
— id: 114731, year: 2009, vol: 13, page: 3898, stat: Journal Article,

Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research
Wich, Lindsay G; Hamilton, Heather K; Shapiro, Richard L; Pavlick, Anna; Berman, Russell S; Polsky, David; Goldberg, Judith D; Hernando, Eva; Manga, Prashiela; Krogsgaard, Michelle; Kamino, Hideko; Darvishian, Farbod; Lee, Peng; Orlow, Seth J; Ostrer, Harry; Bhardwaj, Nina; Osman, Iman
2009 ;1(1):35-43, American journal of translational research
— id: 105566, year: 2009, vol: 1, page: 35, stat: Journal Article,

Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, Juan C; O'Loghlen, Ana; Banito, Ana; Guijarro, Maria V; Augert, Arnaud; Raguz, Selina; Fumagalli, Marzia; Da Costa, Marco; Brown, Celia; Popov, Nikolay; Takatsu, Yoshihiro; Melamed, Jonathan; d'Adda di Fagagna, Fabrizio; Bernard, David; Hernando, Eva; Gil, Jesus
2008 Jun 13;133(6):1006-1018, Cell
— id: 90815, year: 2008, vol: 133, page: 1006, stat: Journal Article,

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
Guardavaccaro, Daniele; Frescas, David; Dorrello, N Valerio; Peschiaroli, Angelo; Multani, Asha S; Cardozo, Timothy; Lasorella, Anna; Iavarone, Antonio; Chang, Sandy; Hernando, Eva; Pagano, Michele
2008 Mar 20;452(7185):365-369, Nature
— id: 78365, year: 2008, vol: 452, page: 365, stat: Journal Article,

Cancer. Aneuploidy advantages?
Hernando, Eva
2008 Oct 31;322(5902):692-693, Science
— id: 90814, year: 2008, vol: 322, page: 692, stat: Journal Article,

Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology
Krizhanovsky, V; Xue, W; Zender, L; Yon, M; Hernando, E; Lowe, S W
2008 ;73:513-522, Cold Spring Harbor symposia on quantitative biology
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A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas
Matushansky, Igor; Hernando, Eva; Socci, Nicholas D; Matos, Tulio; Mills, Joslyn; Edgar, Mark A; Schwartz, Gary K; Singer, Samuel; Cordon-Cardo, Carlos; Maki, Robert G
2008 Apr;172(4):1069-1080, American journal of pathology
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Tissue-specific and reversible RNA interference in transgenic mice
Dickins, Ross A; McJunkin, Katherine; Hernando, Eva; Premsrirut, Prem K; Krizhanovsky, Valery; Burgess, Darren J; Kim, Sang Yong; Cordon-Cardo, Carlos; Zender, Lars; Hannon, Gregory J; Lowe, Scott W
2007 Jul;39(7):914-921, Nature genetics
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Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
Feng, Zhaohui; Hu, Wenwei; Teresky, Angelika K; Hernando, Eva; Cordon-Cardo, Carlos; Levine, Arnold J
2007 Oct 16;104(42):16633-16638, Proceedings of the National Academy of Sciences of the United States of America
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microRNAs and cancer: role in tumorigenesis, patient classification and therapy
Hernando, E
2007 Mar;9(3):155-160, Clinical & translational oncology
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The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
Hernando, Eva; Charytonowicz, Elizabeth; Dudas, Maria E; Menendez, Silvia; Matushansky, Igor; Mills, Joslyn; Socci, Nicholas D; Behrendt, Nille; Ma, Li; Maki, Robert G; Pandolfi, Pier Paolo; Cordon-Cardo, Carlos
2007 Jun;13(6):748-753, Nature medicine
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Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
Matushansky, Igor; Hernando, Eva; Socci, Nicholas D; Mills, Joslyn E; Matos, Tulio A; Edgar, Mark A; Singer, Samuel; Maki, Robert G; Cordon-Cardo, Carlos
2007 Nov;117(11):3248-3257, Journal of clinical investigation
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Role of the chromobox protein CBX7 in lymphomagenesis
Scott, Clare L; Gil, Jesus; Hernando, Eva; Teruya-Feldstein, Julie; Narita, Masako; Martinez, Dolores; Visakorpi, Tapio; Mu, David; Cordon-Cardo, Carlos; Peters, Gordon; Beach, David; Lowe, Scott W
2007 Mar 27;104(13):5389-5394, Proceedings of the National Academy of Sciences of the United States of America
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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
Sotillo, Rocio; Hernando, Eva; Diaz-Rodriguez, Elena; Teruya-Feldstein, Julie; Cordon-Cardo, Carlos; Lowe, Scott W; Benezra, Robert
2007 Jan;11(1):9-23, Cancer cell
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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, Wen; Zender, Lars; Miething, Cornelius; Dickins, Ross A; Hernando, Eva; Krizhanovsky, Valery; Cordon-Cardo, Carlos; Lowe, Scott W
2007 Feb 8;445(7128):656-660, Nature
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Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells
Garcia-Morales, Pilar; Hernando, Eva; Carrasco-Garcia, Estefania; Menendez-Gutierrez, Maria Piedad; Saceda, Miguel; Martinez-Lacaci, Isabel
2006 Sep;5(9):2172-2181, Molecular cancer therapeutics
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p73beta-Mediated apoptosis requires p57kip2 induction and IEX-1 inhibition
Gonzalez, Susana; Perez-Perez, Manuel M; Hernando, Eva; Serrano, Manuel; Cordon-Cardo, Carlos
2005 Mar 15;65(6):2186-2192, Cancer research
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A microRNA polycistron as a potential human oncogene
He, Lin; Thomson, J Michael; Hemann, Michael T; Hernando-Monge, Eva; Mu, David; Goodson, Summer; Powers, Scott; Cordon-Cardo, Carlos; Lowe, Scott W; Hannon, Gregory J; Hammond, Scott M
2005 Jun 9;435(7043):828-833, Nature
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Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice
Kontou, Maria; Govindasamy, Lakshmanan; Nam, Hyun-Joo; Bryant, Nathan; Llamas-Saiz, Antonio L; Foces-Foces, Concepcion; Hernando, Eva; Rubio, Mari-Paz; McKenna, Robert; Almendral, Jose M; Agbandje-McKenna, Mavis
2005 Sep;79(17):10931-10943, Journal of virology
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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
Hernando, Eva; Nahle, Zaher; Juan, Gloria; Diaz-Rodriguez, Elena; Alaminos, Miguel; Hemann, Michael; Michel, Loren; Mittal, Vivek; Gerald, William; Benezra, Robert; Lowe, Scott W; Cordon-Cardo, Carlos
2004 Aug 12;430(7001):797-802, Nature
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Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells
Michel, Loren; Diaz-Rodriguez, Elena; Narayan, Gopeshwar; Hernando, Eva; Murty, Vundavalli V V S; Benezra, Robert
2004 Mar 30;101(13):4459-4464, Proceedings of the National Academy of Sciences of the United States of America
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Tumor promotion by Mdm2 splice variants unable to bind p53
Fridman, Jordan S; Hernando, Eva; Hemann, Michael T; de Stanchina, Elisa; Cordon-Cardo, Carlos; Lowe, Scott W
2003 Sep 15;63(18):5703-5706, Cancer research
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An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
Hemann, Michael T; Fridman, Jordan S; Zilfou, Jack T; Hernando, Eva; Paddison, Patrick J; Cordon-Cardo, Carlos; Hannon, Gregory J; Lowe, Scott W
2003 Mar;33(3):396-400, Nature genetics
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Protein signals regulating the nuclear-cytoplasmic traffic of the parovovirus MVM capsid
Valle N; Ramirez JC; Lombardo E; Maroto B; Garcia J; Hernando E; Riolobos L; Almendral JM
2003 ;5:271-285, Recent research developments in virology
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Separation of live cells in different phases of the cell cycle for gene expression analysis
Juan, Gloria; Hernando, Eva; Cordon-Cardo, Carlos
2002 Dec 1;49(4):170-175, Cytometry
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Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer
Hernando, E; Orlow, I; Liberal, V; Nohales, G; Benezra, R; Cordon-Cardo, C
2001 Jul 20;95(4):223-227, International journal of cancer
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Biochemical and physical characterization of parvovirus minute virus of mice virus-like particles
Hernando, E; Llamas-Saiz, A L; Foces-Foces, C; McKenna, R; Portman, I; Agbandje-McKenna, M; Almendral, J M
2000 Feb 15;267(2):299-309, Virology
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