Gabriele Grunig

Biosketch / Results /

Gabriele Grunig

Professor, Department of Environmental Medicine;Professor, Department of Medicine
Environmental Medicine

Contact Info

57 Old Forge Rd.
Tuxedo, NY 10987



1984 — Veterinary Med Univ of Zurich, Graduate Education
1994 — Cornell U, Graduate Education

Research Summary

Exposure to airborne pollutants and cigarette smoke are major causes of chronic inflammation in the lungs. The lungs also become more susceptible to infection with viruses or bacteria. The result is the dysfunction of the bronchi that transport air to and from the alveoli, and to the blood vessels that circulate the blood through the lungs. The major focus point of research in the laboratory is to define the role of secreted proteins by which immune cells communicate with the cells that make up the structure of the lungs. This research has identified one of these mediators, called Interleukin-13 (IL-13), to directly initiate the processes that induce the cardinal signs of asthma: bronchial constriction, inflammation and increased mucus production. At the present time, we have a grant from the National Institute of Health that has the goal to help to develop a drug that inhibits Interleukin-13 and a few other key mediators of asthma. We have most recently begun to investigate the blood vessels in the lungs. We have shown for the first time experimentally that the immune response can induce severe wall-thickening of arteries (structure stained in brown by labeling with a smooth muscle specific antibody) in the lungs. In addition, the studies showed that Interleukin-13 (IL-13) is a critical, indirect communicator in the process that leads to the severe thickening of the pulmonary arterial walls. This thickening of the pulmonary arterial walls has been described in patients who have pulmonary hypertension, a debilitating disease that frequently accompanies chronic lung disease caused by smoking. This research might aid in developing new methods to follow disease progression and tailor treatment strategies in patients with pulmonary hypertension.

Research Interests

Lung diseases associated with environmental pollutants: asthma, chronic inflammation, airway and arterial remodeling; Interactions between the immune system and environmental pollutants; Soluble mediators (cytokines such as IL-13, IL-10 family cytokines)

Coexpression of type 2 immune targets in sputum-derived epithelial and dendritic cells from asthmatic patients
Bleck, Bertram; Kazeros, Angeliki; Bakal, Keren; Garcia-Medina, Lymaris; Adams, Alexandra; Liu, Mengling; Lee, Richard A; Tse, Doris B; Chiu, Amanda; Grunig, Gabriele; Egan, John P 3rd; Reibman, Joan
2015-04-06; 1097-6825,Journal of allergy & clinical immunology - id: 1518952, year: 2015 JOURNAL ARTICLE

The Effects of Antigen-Specific IgG1 Antibody for the Pulmonary-Hypertension-Phenotype and B Cells for Inflammation in Mice Exposed to Antigen and Fine Particles from Air Pollution
Park, Sung-Hyun; Chen, Wen-Chi; Durmus, Nedim; Bleck, Bertram; Reibman, Joan; Riemekasten, Gabriela; Grunig, Gabriele
2015-06-22; 1932-6203,PLoS one - id: 1632212, year: 2015 Journal Article

Short-term inhalation of cadmium oxide nanoparticles alters pulmonary dynamics associated with lung injury, inflammation, and repair in a mouse model
Blum, Jason L; Rosenblum, Lauren K; Grunig, Gabriele; Beasley, Mary Beth; Xiong, Judy Q; Zelikoff, Judith T
2014-01-20; 0895-8378,Inhalation toxicology - id: 741222, year: 2014 Journal Article

Dust events, pulmonary diseases and immune system
Esmaeil, Nafiseh; Gharagozloo, Marjan; Rezaei, Abbas; Grunig, Gabriele
2014-04-25; 2164-7712,American journal of clinical & experimental immunology - id: 909832, year: 2014 REVIEW

Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature
Grunig, Gabriele; Marsh, Leigh M; Esmaeil, Nafiseh; Jackson, Katelin; Gordon, Terry; Reibman, Joan; Kwapiszewska, Grazyna; Park, Sung-Hyun
2014-07-25; 2045-8932,Pulmonary circulation - id: 1074762, year: 2014 Journal Article; Review