Oded Gonen

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Oded Gonen

Professor, Department of Radiology
Professor, Department of Neuroscience and Physiology


Contact Info

Address
660 First Avenue
New York, NY 10016

212/263-3532
Oded.Gonen@nyumc.org

Research Summary

In vivo localized MR spectroscopy (MRS) facilitates non-invasive investigations of the physiology and biochemistry (as opposed to the anatomic and morphologic information from MRI). The primarily focus of our research is the human brain, and to a lesser extent, other organs, e.g., the liver and pancreas, probed by 3-dimensional localized proton (but also phosphorus-31 and fluorine-19) MRS. An example of the differences and similarities between MRI and MRS is illustrated in the figure below. Our research projects propagate along three, parallel paths: First, technique development - the design of new localization methods, based on Fourier and Hadamard spatial encoding, to accommodate the higher magnetic fields that are now becoming available, and to tailor these methods to anatomies that traditionally have been inaccessible to existing methodologies, e.g., the spinal cord, optic nerve and cortex. Second, application of these methods to characterize normal and pathological metabolism by quantitatively comparing metabolic levels in the different anatomical structures. Our current clinical focuses are the processes of normal aging, multiple sclerosis and traumatic brain injury. Finally, the third direction is post- processing and visualization methodology and software development, to display the copious 3D information in a manner that will not hide the forest for the trees, because, after all, this is a department of radiology, so here, image is everything.

Research Interests

Magnetic Resonance Spectroscopy and its applications to cancer, neurodegenerative diseases and psychiatric disorders. The development of MR-spectroscopy tools to support to medical and biomedical research.

Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity
Malaspina, Dolores; Kranz, Thorsten M; Heguy, Adriana; Harroch, Sheila; Mazgaj, Robert; Rothman, Karen; Berns, Adam; Hasan, Sumya; Antonius, Daniel; Goetz, Raymond; Lazar, Mariana; Chao, Moses V; Gonen, Oded. Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity. Schizophrenia research. 2016 Feb 28;172(1-3):94-100 (2009242)

Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia
Mazgaj, Robert; Tal, Assaf; Goetz, Raymond; Lazar, Mariana; Rothman, Karen; Messinger, Julie Walsh; Malaspina, Dolores; Gonen, Oded. Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia. Brain imaging & behavior. 2016 Mar ;10(1):115-123 (1514002)

Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T
Meyer, E J; Kirov, I I; Tal, A; Davitz, M S; Babb, J S; Lazar, M; Malaspina, D; Gonen, O. Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T. AJNR. American journal of neuroradiology. 2016 Jul 21;:?-? (2185592)

MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update
Wu, Xin; Kirov, Ivan I; Gonen, Oded; Ge, Yulin; Grossman, Robert I; Lui, Yvonne W. MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update. Radiology. 2016 Jun;279(3):693-707 (2111672)

Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge
Chawla, S; Ge, Y; Lu, H; Marshall, O; Davitz, M S; Fatterpekar, G; Soher, B J; Gonen, O. Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge. AJNR. American journal of neuroradiology. 2015 Aug 20;36(11):2055-2061 (1732502)