Oded Gonen

Biosketch / Results /

Oded Gonen

Professor, Department of Radiology;Professor, Department of Neuroscience Institute
Radiology

Contact Info

Address
660 First Avenue
New York, NY 10016

212/263-3532
Oded.Gonen@nyumc.org

Education

1985-1989 — M.I.T, PostDoctoral Training

Research Summary

In vivo localized MR spectroscopy (MRS) facilitates non-invasive investigations of the physiology and biochemistry (as opposed to the anatomic and morphologic information from MRI). The primarily focus of our research is the human brain, and to a lesser extent, other organs, e.g., the liver and pancreas, probed by 3-dimensional localized proton (but also phosphorus-31 and fluorine-19) MRS. An example of the differences and similarities between MRI and MRS is illustrated in the figure below. Our research projects propagate along three, parallel paths: First, technique development - the design of new localization methods, based on Fourier and Hadamard spatial encoding, to accommodate the higher magnetic fields that are now becoming available, and to tailor these methods to anatomies that traditionally have been inaccessible to existing methodologies, e.g., the spinal cord, optic nerve and cortex. Second, application of these methods to characterize normal and pathological metabolism by quantitatively comparing metabolic levels in the different anatomical structures. Our current clinical focuses are the processes of normal aging, multiple sclerosis and traumatic brain injury. Finally, the third direction is post- processing and visualization methodology and software development, to display the copious 3D information in a manner that will not hide the forest for the trees, because, after all, this is a department of radiology, so here, image is everything.

Research Interests

Magnetic Resonance Spectroscopy and its applications to cancer, neurodegenerative diseases and psychiatric disorders. The development of MR-spectroscopy tools to support to medical and biomedical research.

N-acetyl-aspartate levels correlate with intra-axonal compartment parameters from diffusion MRI
Grossman, Elan J; Kirov, Ivan I; Gonen, Oded; Novikov, Dmitry S; Davitz, Matthew S; Lui, Yvonne W; Grossman, Robert I; Inglese, Matilde; Fieremans, Els
2015-06-07; 1095-9572,Neuroimage - id: 1615472, year: 2015 JOURNAL ARTICLE

Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia
Mazgaj, Robert; Tal, Assaf; Goetz, Raymond; Lazar, Mariana; Rothman, Karen; Messinger, Julie Walsh; Malaspina, Dolores; Gonen, Oded
2015-03-30; 1931-7565,Brain imaging & behavior - id: 1514002, year: 2015 JOURNAL ARTICLE

Inflammation in the anterior cingulate cortex (ACC) and associations with olfactory hedonics and anhedonia in schizophrenia
Walsh-Messinger, J; Keller, A; Cieslak, K; Rotondo, E; Goetz, R; Gonen, O; Malaspina, D
2015-05-04; 0586-7614,Schizophrenia bulletin - id: 1560852, year: 2015

Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: A 3D, multivoxel proton magnetic resonance spectroscopy study
Wu, W E; Babb, J S; Tal, A; Kirov, I I; George, A E; Ratai, E-M; Gonzalez, R G; Gonen, O
2015-06-28; 1468-1293,HIV medicine - id: 1640042, year: 2015 Journal Article

Global N-Acetylaspartate in Normal Subjects, Mild Cognitive Impairment and Alzheimer's Disease Patients
Glodzik, Lidia; Sollberger, Marc; Gass, Achim; Gokhale, Amit; Rusinek, Henry; Babb, James S; Hirsch, Jochen G; Amann, Michael; Monsch, Andreas U; Gonen, Oded
2014-08-26; 1387-2877,Journal of Alzheimer's disease - id: 1141962, year: 2014 JOURNAL ARTICLE