Leslie I Gold

Biosketch / Results /

Leslie I Gold, Ph.D.

Associate Professor;
Departments of Medicine (Clin Pharm Div) and Pathology

Contact Info

Address
550 First Avenue
Floor 16S Room 13
New Bellevue
New York, NY 10016

212-263-6320
212-263-7640
Leslie.Gold@nyumc.org

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Education

1980-1983 — Dr. Gold was a Postdoctoral Trainee in Rheumatology at NYU Medical School specializing in Protein Chemistry and structure/function relationships of fibronectin. Dr. Gold received a 3 year fellowship from the Arthritis Foundation, PostDoctoral Training
— New York University School of Medicine, Graduate Education
— NYU, Medical Education
1980 — NYU Medical School, Graduate Education

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Research Summary

Cancer Biology:



The laboratory studies loss of growth regulation in cancer, particularly hormone-regulated cancers. Specific objectives emphasize alterations in cancer cells with respect to the regulation of cell cycle proteins by ubiquitin-mediated degradation, nuclear-cytoplasmic shuttling of cell cycle proteins, growth factor signaling pathways, particularly TGF-β, hormone-regulated growth, and stromal/epithelial interactions. For example, we are the first to show that TGF-β, estrogen, and progesterone control endometrial epithelial cell proliferation by regulating the protein levels of the cyclin-dependent kinase inhibitor, p27kip1 (p27) through the ubiquitin pathway (Diagram). Therefore, identifying specific inhibitors of the E3 ligase, Skp2 to potentially prevent p27 degradation to regain growth control is a potential specific therapy for endometrial carcinoma and other human cancers showing loss of nuclear p27. We utilize epithelial and stromal cells, isolated from normal and malignant endometrium, in primary cultures, co-cultures, and 3-dimensional matrices as our major model systems. These physiological paradigms afford optimal approaches to understanding the role of stromal cells surrounding malignant glands in malignant progression (tumor microenvironment) and a greater probability for defining molecular targets for translation into novel treatments for cancer prevention and therapy.

Wound Healing:



We discovered that the intracellular calcium-binding endoplasmic reticulum (ER) chaperone protein, calreticulin has non-ER functions of topically enhancing the rate and quality of wound healing and exogenously, inducing proliferation, migration, and matrix protein induction of cells involved in the wound healing process. The mechanisms involved in how calreticulin induces these functions from the outside-inward and the receptors are unknown opening a new area for the lab to explore.

Honors:



Permanent member of Metabolic Pathology and Tumor Cell Biology IRGs, NIH; Council, American Association Cancer Research (WICR), SEP Review Panel for Gynecological SPORE, NIH; Review Panel for AACR Fellowships, Ad hoc Reviewer for numerous IRGs, NIH; Associate Editor, Molecular Signaling.

Research Interests

Translational medicine, hormonal carcinogenesis, normal and malignant growth regulatory mechanisms, post-translational protein modifications, cell cycle, ubiquitin pathway regulation of growth, TGF-β signaling, stromal/epithelial interactions and cell substrate interactions in cancer progression, molecular targets for cancer prevention and therapy, wound/tissue repair, developing physiological model systems.

Research Keywords

cancer, inflammation, growth regulation, growth factors, TGF-B, fibronectin, cell cycle, tissue repair, proteomics, gonadal steroids<br><br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

A new role for the multifunctionalwound healing agent calreticulin (CRT) in combating infection: Significance for treating diabetic foot ulcers
Gold, L I; Pavlides, S C; Ojeda, J; Eaton, B; Panchal, R G
2014 March- April 2014;22(2):A42-A42, Wound repair & regeneration
— id: 1361312, year: 2014, vol: 22, page: A42, stat: Journal Article,

Binding Of Apoptotic Fetal Cardiocytes By Anti-Ro Antibodies Stimulates uPA/uPAR-Dependent Macrophage Infiltration and M2 Type Phenotype
Briasouli, Paraskevi ; Pavlides, Savvas ; Gold, Leslie ; Halushka, Mark ; Buyon, Jill P.
2013 OCT;65 10 10(SI):S750-S750, Arthritis & rheumatism
— id: 657512, year: 2013, vol: 65 10 10, page: S750, stat: Journal Article,

Exogenous calreticulin improves diabetic wound healing (vol 20, pg 715, 2012)
Greives, Matthew R.; Samra, Fares; Pavlides, Savvas C.; Blechman, Keith M.; Naylor, Sara-Megumi; Woodrell, Christopher D.; Cadacio, Caprice; Levine, Jamie P.; Asoulin, Tara A.; Michalak, Marek; Warren, Stephen M.; Gold, Leslie I.
2013 MAR-APR;21(2):337-337, Wound repair & regeneration
— id: 288862, year: 2013, vol: 21, page: 337, stat: Journal Article,

Inhibitors of Skp2 E3ligase stabilize nuclear p27(kip1) for regain of growth regulation in cancer
Pavlides, Savvas C.; Huang, Kuang-Tzu; Wu, Lily; Rueda, Bo R.; Blank, Stephanie V.; Mittal, Khushbakhat R.; Cardozo, Timothy; Gold, Leslie I.
2013 APR 15;73(8 1 1):-, Cancer research
— id: 853222, year: 2013, vol: 73, page: , stat: Journal Article,

Inhibitors of SCF-Skp2/Cks1 E3 Ligase Block Estrogen-Induced Growth Stimulation and Degradation of Nuclear p27kip1: Therapeutic Potential for Endometrial Cancer
Pavlides, Savvas C; Huang, Kuang-Tzu; Reid, Dylan A; Wu, Lily; Blank, Stephanie V; Mittal, Khushbakhat; Guo, Lankai; Rothenberg, Eli; Rueda, Bo; Cardozo, Timothy; Gold, Leslie I
2013 Nov;154(11):4030-4045, Endocrinology
— id: 627252, year: 2013, vol: 154, page: 4030, stat: Journal Article,

Exogenous calreticulin improves diabetic wound healing
Greives, Matthew R; Samra, Fares; Pavlides, Savvas C; Blechman, Keith M; Naylor, Sara-Megumi; Woodrell, Christopher D; Cadacio, Caprice; Levine, Jamie P; Bancroft, Tara A; Michalak, Marek; Warren, Stephen M; Gold, Leslie I
2012 Sep;20(5):715-730, Wound repair & regeneration
— id: 178236, year: 2012, vol: 20, page: 715, stat: Journal Article,

Estrogen and Progesterone Regulate p27kip1 Levels via the Ubiquitin-Proteasome System: Pathogenic and Therapeutic Implications for Endometrial Cancer
Huang, Kuang-Tzu; Pavlides, Savvas C; Lecanda, Jon; Blank, Stephanie V; Mittal, Khushbakhat R; Gold, Leslie I
2012 ;7(9):e46072-e46072 e46072, PLoS one
— id: 179100, year: 2012, vol: 7, page: e46072, stat: Journal Article,

Calreticulin: non-endoplasmic reticulum functions in physiology and disease
Gold, Leslie I; Eggleton, Paul; Sweetwyne, Mariya T; Van Duyn, Lauren B; Greives, Matthew R; Naylor, Sara-Megumi; Michalak, Marek; Murphy-Ullrich, Joanne E
2010 Mar;24(3):665-683, FASEB journal
— id: 107766, year: 2010, vol: 24, page: 665, stat: Journal Article,

UNLOCKING BIOMARKER DISCOVERY FOR EARLY DETECTION OF LUNG CANCER
Ostroff, R.; Bigbee, W.; Franklin, W.; Gold, L.; Mehan, M.; Miller, Y.; Pass, H.; Rom, W.; Siegfried, J.; Stewart, A.; Walker, J.; Weissfeld, J.; Williams, S.; Zichi, D.; Brody, E.
2010 AUG ;31:S14-S14, Tumour biology
— id: 132750, year: 2010, vol: 31, page: S14, stat: Journal Article,

Non-ER outside-in functions of the ER chaperone calreticulin in diabetic wound repair
Samra F.; Naylor S.-M.; Gorovets D.; Pavlides S.; Murphy-Ullrich J.E.; Levine J.P.; Warren S.M.; Gold L.I.
2010 ;18(2):A28-A28, Wound repair & regeneration
— id: 135597, year: 2010, vol: 18, page: A28, stat: Journal Article,

TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest
Lecanda, Jon; Ganapathy, Vidya; D'Aquino-Ardalan, Christine; Evans, Brad; Cadacio, Caprice; Ayala, Aidee; Gold, Leslie I
2009 Mar 1;8(5):742-756, Cell cycle
— id: 93786, year: 2009, vol: 8, page: 742, stat: Journal Article,

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum
Michalak, Marek; Groenendyk, Jody; Szabo, Eva; Gold, Leslie I; Opas, Michal
2009 Feb 1;417(3):651-666, Biochemical journal
— id: 93787, year: 2009, vol: 417, page: 651, stat: Journal Article,

Calreticulin induces matrix proteins and integrins in keratinocytes and fibroblasts for enhanced wound healing
Gold, LI; Greives, MR; Woodrell, C; Chesser, AS; Bancroft, TA; Murphy-Ullrich, JE
2008 MAR-APR ;16(2):A15-A15, Wound repair & regeneration
— id: 76408, year: 2008, vol: 16, page: A15, stat: Journal Article,

Calreticulin enhances porcine wound repair by diverse biological effects
Nanney, Lillian B; Woodrell, Christopher D; Greives, Mathew R; Cardwell, Nancy L; Pollins, Alonda C; Bancroft, Tara A; Chesser, Adrianne; Michalak, Marek; Rahman, Mohammad; Siebert, John W; Gold, Leslie I
2008 Sep;173(3):610-630, American journal of pathology
— id: 93788, year: 2008, vol: 173, page: 610, stat: Journal Article,

Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats
Laping, Nicholas J; Everitt, Jeffrey I; Frazier, Kendall S; Burgert, Mark; Portis, Melisa J; Cadacio, Caprice; Gold, Leslie I; Walker, Cheryl L
2007 May 15;13(10):3087-3099, Clinical cancer research
— id: 76284, year: 2007, vol: 13, page: 3087, stat: Journal Article,

Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium
Lecanda, Jon; Parekh, Trilok V; Gama, Patricia; Lin, Ke; Liarski, Vladimir; Uretsky, Seth; Mittal, Khush; Gold, Leslie I
2007 Feb 1;67(3):1007-1018, Cancer research
— id: 70879, year: 2007, vol: 67, page: 1007, stat: Journal Article,

Overview of the role for calreticulin in the enhancement of wound healing through multiple biological effects
Gold, Leslie I; Rahman, Mohammad; Blechman, Keith M; Greives, Matthew R; Churgin, Samara; Michaels, Joseph; Callaghan, Matthew J; Cardwell, Nancy L; Pollins, Alonda C; Michalak, Marek; Siebert, John W; Levine, Jamie P; Gurtner, Geoffrey C; Nanney, Lillian B; Galiano, Robert D; Cadacio, Caprice L
2006 Sep;11(1):57-65, Journal of investigative dermatology symposium proceedings
— id: 69252, year: 2006, vol: 11, page: 57, stat: Journal Article,

The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen
Kurita, Takeshi; Medina, Roanna; Schabel, Alex B; Young, Peter; Gama, Patricia; Parekh, Trilok V; Brody, Joel; Cunha, Gerald R; Osteen, Kevin G; Bruner-Tran, Kaylon L; Gold, Leslie I
2005 Jul;73(6):313-322, Differentiation
— id: 62762, year: 2005, vol: 73, page: 313, stat: Journal Article,

Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen
Pole, Jessica C M; Gold, Leslie I; Orton, Terry; Huby, Russell; Carmichael, Paul L
2005 Jan 5;206(1):91-109, Toxicology
— id: 62763, year: 2005, vol: 206, page: 91, stat: Journal Article,

Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis
Khalil, Nasreen; Parekh, Trilok V; O'Connor, Robert N; Gold, Leslie I
2002 Apr-May;28(3):233-250, Experimental lung research
— id: 62764, year: 2002, vol: 28, page: 233, stat: Journal Article,

Transforming growth factor beta signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition
Parekh, Trilok V; Gama, Patricia; Wen, Xie; Demopoulos, Rita; Munger, John S; Carcangiu, Maria-Luisa; Reiss, Michael; Gold, Leslie I
2002 May 15;62(10):2778-2790, Cancer research
— id: 32907, year: 2002, vol: 62, page: 2778, stat: Journal Article,

Quantitative assessment of cranial defect healing and correlation with the expression of TGF-beta
Gosain, A K; Song, L; Yu, P; Mehrara, B J; Maeda, C Y; Gold, L I; Longaker, M T
2001 Jul;12(4):401-404, Journal of craniofacial surgery
— id: 76286, year: 2001, vol: 12, page: 401, stat: Journal Article,

Biological effects of transforming growth factor-beta(1) in idiopathic pulmonary fibrosis may be regulated by the activation of latent transforming growth factor-beta(1) and the differential expression of transforming growth factor-beta receptors
Khalil, N; O'Connor, R; Gold, L I; Parekh, T; Raghu, G
2001 Jul;120(1 Suppl):48S-48S, Chest
— id: 76287, year: 2001, vol: 120, page: 48S, stat: Journal Article,

Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis
Khalil, N; Parekh, T V; O'Connor, R; Antman, N; Kepron, W; Yehaulaeshet, T; Xu, Y D; Gold, L I
2001 Dec;56(12):907-915, Thorax
— id: 76285, year: 2001, vol: 56, page: 907, stat: Journal Article,

TGF-beta isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis
Gold LI; Jussila T; Fusenig NE; Stenback F
2000 Apr;190(5):579-588, Journal of pathology
— id: 11793, year: 2000, vol: 190, page: 579, stat: Journal Article,

Osteogenesis in cranial defects: reassessment of the concept of critical size and the expression of TGF-beta isoforms
Gosain, A K; Song, L; Yu, P; Mehrara, B J; Maeda, C Y; Gold, L I; Longaker, M T
2000 Aug;106(2):360-71; discussion 372, Plastic & reconstructive surgery
— id: 76288, year: 2000, vol: 106, page: 360, stat: Journal Article,

Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma
Abou-Shady, M; Baer, H U; Friess, H; Berberat, P; Zimmermann, A; Graber, H; Gold, L I; Korc, M; Buchler, M W
1999 Mar;177(3):209-215, American journal of surgery
— id: 76291, year: 1999, vol: 177, page: 209, stat: Journal Article,

Neonatal estrogen exposure alters the transforming growth factor-beta signaling system in the developing rat prostate and blocks the transient p21(cip1/waf1) expression associated with epithelial differentiation
Chang, W Y; Birch, L; Woodham, C; Gold, L I; Prins, G S
1999 Jun;140(6):2801-2813, Endocrinology
— id: 76290, year: 1999, vol: 140, page: 2801, stat: Journal Article,

Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis
di Mola, F F; Friess, H; Martignoni, M E; Di Sebastiano, P; Zimmermann, A; Innocenti, P; Graber, H; Gold, L I; Korc, M; Buchler, M W
1999 Jul;230(1):63-71, Annals of surgery
— id: 76289, year: 1999, vol: 230, page: 63, stat: Journal Article,

The role for transforming growth factor-beta (TGF-beta) in human cancer
Gold LI
1999 ;10(4):303-360, Critical reviews in oncogenesis
— id: 11849, year: 1999, vol: 10, page: 303, stat: Journal Article,

Loss of growth regulation by transforming growth factor-beta (TGF-beta) in human cancers: studies on endometrial carcinoma
Gold LI; Parekh TV
1999 ;17(1):73-92, Seminars in reproductive endocrinology
— id: 11987, year: 1999, vol: 17, page: 73, stat: Journal Article,

Comparison of the fibrin-binding activities in the N- and C-termini of fibronectin
Rostagno AA; Schwarzbauer JE; Gold LI
1999 Mar 1;338 ( Pt 2):375-386, Biochemical journal
— id: 7438, year: 1999, vol: 338 ( Pt 2), page: 375, stat: Journal Article,

Increased levels of transforming growth factor-beta in HIV-associated nephropathy
Yamamoto T; Noble NA; Miller DE; Gold LI; Hishida A; Nagase M; Cohen AH; Border WA
1999 Feb;55(2):579-592, Kidney international
— id: 7467, year: 1999, vol: 55, page: 579, stat: Journal Article,

Transforming growth factor betas and their receptors in human liver cirrhosis
Baer, H U; Friess, H; Abou-Shady, M; Berberat, P; Zimmermann, A; Gold, L I; Korc, M; Buchler, M W
1998 Dec;10(12):1031-1039, European journal of gastroenterology & hepatology
— id: 76292, year: 1998, vol: 10, page: 1031, stat: Journal Article,

Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta
Evanko SP; Raines EW; Ross R; Gold LI; Wight TN
1998 Feb;152(2):533-546, American journal of pathology
— id: 7557, year: 1998, vol: 152, page: 533, stat: Journal Article,

Enhanced expression of TGF-betas and their receptors in human acute pancreatitis
Friess H; Lu Z; Riesle E; Uhl W; Brundler AM; Horvath L; Gold LI; Korc M; Buchler MW
1998 Jan;227(1):95-104, Annals of surgery
— id: 8028, year: 1998, vol: 227, page: 95, stat: Journal Article,

A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1
Picon A; Gold LI; Wang J; Cohen A; Friedman E
1998 Jun;7(6):497-504, Cancer epidemiology biomarkers & prevention
— id: 8083, year: 1998, vol: 7, page: 497, stat: Journal Article,

Type I (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair
Gold LI; Sung JJ; Siebert JW; Longaker MT
1997 Jan;150(1):209-222, American journal of pathology
— id: 12427, year: 1997, vol: 150, page: 209, stat: Journal Article,

Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases
Jagirdar J; Lee TC; Reibman J; Gold LI; Aston C; Begin R; Rom WN
1997 Sep;105 Suppl 5:1197-1203, Environmental health perspectives
— id: 12204, year: 1997, vol: 105 Suppl 5, page: 1197, stat: Journal Article,

Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression
Kloen, P; Gebhardt, M C; Perez-Atayde, A; Rosenberg, A E; Springfield, D S; Gold, L I; Mankin, H J
1997 Dec 15;80(12):2230-2239, Cancer
— id: 76293, year: 1997, vol: 80, page: 2230, stat: Journal Article,

Immunohistochemical localization of transforming growth factor-beta and insulin-like growth factor-I in asbestosis in the sheep model
Lee TC; Gold LI; Reibman J; Aston C; Begin R; Rom WN; Jagirdar J
1997 ;69(3):157-164, International archives of occupational & environmental health
— id: 12416, year: 1997, vol: 69, page: 157, stat: Journal Article,

Exogenous and endogenous transforming growth factors-beta influence elastin gene expression in cultured lung fibroblasts
McGowan, S E; Jackson, S K; Olson, P J; Parekh, T; Gold, L I
1997 Jul;17(1):25-35, American journal of respiratory cell & molecular biology
— id: 76294, year: 1997, vol: 17, page: 25, stat: Journal Article,

Differential localization of transforming growth factor-beta isoforms in human gastric mucosa and overexpression in gastric carcinoma
Naef, M; Ishiwata, T; Friess, H; Buchler, M W; Gold, L I; Korc, M
1997 Apr 10;71(2):131-137, International journal of cancer
— id: 76295, year: 1997, vol: 71, page: 131, stat: Journal Article,

Increased expression of transforming growth factor beta s after acute oedematous pancreatitis in rats suggests a role in pancreatic repair
Riesle, E; Friess, H; Zhao, L; Wagner, M; Uhl, W; Baczako, K; Gold, L I; Korc, M; Buchler, M W
1997 Jan;40(1):73-79, Gut: journal of the British Society of Gastroenterology
— id: 76296, year: 1997, vol: 40, page: 73, stat: Journal Article,

Studies in cranial suture biology: Part I. Increased immunoreactivity for TGF-beta isoforms (beta 1, beta 2, and beta 3) during rat cranial suture fusion [see comments]
Roth DA; Longaker MT; McCarthy JG; Rosen DM; McMullen HF; Levine JP; Sung J; Gold LI
1997 Mar;12(3):311-321, Journal of bone & mineral research
— id: 12370, year: 1997, vol: 12, page: 311, stat: Journal Article,

Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection
Caver, T E; O'Sullivan, F X; Gold, L I; Gresham, H D
1996 Dec 1;98(11):2496-2506, Journal of clinical investigation
— id: 76297, year: 1996, vol: 98, page: 2496, stat: Journal Article,

Upregulation of transforming growth factors betas and collagen suggest a role in pancreatic healing following edematous pancreatitis in rats
Friess, H; Riesle, E; Zhao, L; Baczako, K; Gold, LI; Korc, M; Buchier, MW
1996 APR ;110(4):A389-A389, Gastroenterology
— id: 98382, year: 1996, vol: 110, page: A389, stat: Journal Article,

Altered expression of transforming growth factor-beta S in chronic renal rejection
Horvath, L Z; Friess, H; Schilling, M; Borisch, B; Deflorin, J; Gold, L I; Korc, M; Buchler, M W
1996 Aug;50(2):489-498, Kidney international
— id: 76299, year: 1996, vol: 50, page: 489, stat: Journal Article,

Distribution of transforming growth factor-beta isoforms in human immunodeficiency virus-1 encephalitis
Johnson, M D; Gold, L I
1996 Jul;27(7):643-649, Human pathology
— id: 76301, year: 1996, vol: 27, page: 643, stat: Journal Article,

Inward growth of colonic adenomatous polyps
Moss, S F; Liu, T C; Petrotos, A; Hsu, T M; Gold, L I; Holt, P R
1996 Dec;111(6):1425-1432, Gastroenterology
— id: 76298, year: 1996, vol: 111, page: 1425, stat: Journal Article,

Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes
Rostagno A; Vidal R; Kumar A; Chuba J; Niederman G; Gold L; Frangione B; Ghiso J; Gallo G
1996 Nov;28(5):676-684, American journal of kidney diseases
— id: 7254, year: 1996, vol: 28, page: 676, stat: Journal Article,

Biochemical analysis of the interaction of fibronectin with IgG and localization of the respective binding sites
Rostagno A; Williams M; Frangione B; Gold LI
1996 Apr;33(6):561-572, Molecular immunology
— id: 7043, year: 1996, vol: 33, page: 561, stat: Journal Article,

Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy
Shankland, S J; Pippin, J; Pichler, R H; Gordon, K L; Friedman, S; Gold, L I; Johnson, R J; Couser, W G
1996 Jul;50(1):116-124, Kidney international
— id: 76300, year: 1996, vol: 50, page: 116, stat: Journal Article,

Transforming growth factor-beta protein and messenger RNA expression is increased in the closing ductus arteriosus
Tannenbaum, JE; Waleh, NS; Mauray, F; Gold, L; Perkett, EA; Clyman, RI
1996 MAR ;39(3):427-434, Pediatric research
— id: 98398, year: 1996, vol: 39, page: 427, stat: Journal Article,

Expression of transforming growth factor-beta isoforms in human glomerular diseases
Yamamoto, T; Noble, N A; Cohen, A H; Nast, C C; Hishida, A; Gold, L I; Border, W A
1996 Feb;49(2):461-469, Kidney international
— id: 76302, year: 1996, vol: 49, page: 461, stat: Journal Article,

ACTIVE MACROPHAGE-ASSOCIATED TGF-BETA COLOCALIZES WITH TYPE-I PROCOLLAGEN GENE-EXPRESSION IN ATHEROSCLEROTIC HUMAN PULMONARY-ARTERIES
BAHADORI, L; MILDER, J; GOLD, L; BOTNEY, M
1995 MAY ;146(5):1140-1149, American journal of pathology
— id: 87301, year: 1995, vol: 146, page: 1140, stat: Journal Article,

Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium
Bruner, K L; Rodgers, W H; Gold, L I; Korc, M; Hargrove, J T; Matrisian, L M; Osteen, K G
1995 Aug 1;92(16):7362-7366, Proceedings of the National Academy of Sciences of the United States of America
— id: 76303, year: 1995, vol: 92, page: 7362, stat: Journal Article,

The in vivo effect of hyaluronan associated protein-collagen complex on wound repair
Cabrera RC; Siebert JW; Eidelman Y; Gold LI; Longaker MT; Garg HG
1995 Sep;37(1):151-158, Biochemistry & molecular biology international
— id: 6986, year: 1995, vol: 37, page: 151, stat: Journal Article,

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer
Friedman, E; Gold, L I; Klimstra, D; Zeng, Z S; Winawer, S; Cohen, A
1995 Jul-Aug;4(5):549-554, Cancer epidemiology biomarkers & prevention
— id: 76305, year: 1995, vol: 4, page: 549, stat: Journal Article,

OVEREXPRESSION OF TGF-BETA-1, TGF-BETA-3 AND TGF-BETA RECEPTOR TYPE-II BUT NOT TO TGF-BETA-2 AND TGF-BETA RECEPTOR TYPE-III IN HUMAN LIVER-CIRRHOSIS
FRIESS, H; BERBERAT, P; DEFLORIN, J; BAER, HU; GOLD, LI; KORC, M; BUCHLER, MW
1995 APR ;108(4):A1067-A1067, Gastroenterology
— id: 86751, year: 1995, vol: 108, page: A1067, stat: Journal Article,

OVEREXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA-S AND THEIR RECEPTORS IN ACUTE-PANCREATITIS IN HUMANS
FRIESS, H; BUCHLER, MW; HOFBAUER, B; UHL, W; GOLD, LI; KORC, M
1995 APR ;108(4):A354-A354, Gastroenterology
— id: 86749, year: 1995, vol: 108, page: A354, stat: Journal Article,

TRANSFORMING GROWTH FACTOR-BETA-3 LOCALIZATION DURING REPAIR OF LUNG INJURY
HOFF, CR; GOLD, LI; DAVIDSON, JM
1995 APR ;37(4):A392-A392, Pediatric research
— id: 86762, year: 1995, vol: 37, page: A392, stat: Journal Article,

TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) ISOFORM REACTIVITY IN NORMAL AND NEOPLASTIC BREAST-TISSUE
JHALA, N; BALSARA, G; ALBO, D; GRANICK, M; GOLD, L; ATKINSON, BF; SOLOMON, M
1995 JAN ;72(1):A19-A19, Laboratory investigation
— id: 98426, year: 1995, vol: 72, page: A19, stat: Journal Article,

Spatial and temporal expression of transforming growth factor-beta isoforms during ovine excisional and incisional wound repair
McMullen, H; Longaker, M T; Cabrera, R C; Sung, J; Canete, J; Siebert, J W; Lorenz, H P; Gold, L I
1995 Apr-Jun;3(2):141-156, Wound repair & regeneration
— id: 76307, year: 1995, vol: 3, page: 141, stat: Journal Article,

COMPLEX REGULATION OF TRANSFORMING GROWTH-FACTOR-BETA ISOFORMS IN HYPEROXIC LUNG
PIEDBOEUF, B; GOLD, LI; SUNG, J; KAZZAZ, J; HOROWITZ, S
1995 APR ;37(4):A345-A345, Pediatric research
— id: 98411, year: 1995, vol: 37, page: A345, stat: Journal Article,

Fibronectin/fibrin interaction: Localization of the C-terminal fibrin-binding site
Pollakis, G.; Rostagno, A.; Gold, L. I.
1995 ;6(SUPPL.):383A-383A, Molecular biology of the cell
— id: 101622, year: 1995, vol: 6, page: 383A, stat: Journal Article,

FIBRONECTIN/FIBRIN INTERACTION - LOCALIZATION OF THE C-TERMINAL FIBRIN-BINDING SITE
POLLAKIS, G; ROSTAGNO, A; GOLD, LI
1995 NOV ;6(6738):2225-2225, Molecular biology of the cell
— id: 73962, year: 1995, vol: 6, page: 2225, stat: Journal Article,

FIBRONECTIN BINDS TO CRYOGLOBULINS FOLLOWING THEIR COLD PRECIPITATION
ROSTAGNO, A; GOLD, LI
1995 NOV ;6(6):2224-2224, Molecular biology of the cell
— id: 73963, year: 1995, vol: 6, page: 2224, stat: Journal Article,

Increased expression of transforming growth factor beta isoforms (beta 1, beta 2, beta 3) in bleomycin-induced pulmonary fibrosis
Santana, A; Saxena, B; Noble, N A; Gold, L I; Marshall, B C
1995 Jul;13(1):34-44, American journal of respiratory cell & molecular biology
— id: 76306, year: 1995, vol: 13, page: 34, stat: Journal Article,

Transforming growth factor-beta and matrix protein expression in acute and chronic rejection of human renal allografts
Shihab, F S; Yamamoto, T; Nast, C C; Cohen, A H; Noble, N A; Gold, L I; Border, W A
1995 Aug;6(2):286-294, Journal of the American Society of Nephrology
— id: 76304, year: 1995, vol: 6, page: 286, stat: Journal Article,

Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta
Botney, M D; Bahadori, L; Gold, L I
1994 Feb;144(2):286-295, American journal of pathology
— id: 76312, year: 1994, vol: 144, page: 286, stat: Journal Article,

Localization of transforming growth factor beta isoforms TGF-beta 1, TGF-beta 2, and TGF-beta 3 in surgically induced endometriosis in the rat
Chegini, N; Gold, L I; Williams, R S
1994 Mar;83(3):455-461, Obstetrics & gynecology
— id: 76310, year: 1994, vol: 83, page: 455, stat: Journal Article,

Localization of transforming growth factor beta isoforms TGF-beta 1, TGF-beta 2, and TGF-beta 3 in surgically induced pelvic adhesions in the rat
Chegini, N; Gold, L I; Williams, R S; Masterson, B J
1994 Mar;83(3):449-454, Obstetrics & gynecology
— id: 76311, year: 1994, vol: 83, page: 449, stat: Journal Article,

Increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action
Gold LI; Saxena B; Mittal KR; Marmor M; Goswami S; Nachtigall L; Korc M; Demopoulos RI
1994 May 1;54(9):2347-2358, Cancer research
— id: 6386, year: 1994, vol: 54, page: 2347, stat: Journal Article,

Expression of transforming growth factor-beta-1,2, and 3 mRNA and protein in human cancers
Gold, Leslie I.; Korc, Murray
1994 ;11(3-6):150-156, Digestive surgery
— id: 98809, year: 1994, vol: 11, page: 150, stat: Journal Article,

TGF-beta-1, -beta-2, -beta-3, and IGF-1 localization in rat cranial suture development and fusion
Longaker, Michael T.; Roth, Douglas A.; McMullen, Heather F.; Breitbart, Arnold S.; Wisoff, Jeffrey H.; Han, Victor K.; Gold, Leslie I.; McCarthy, Joseph G.
1994 ;45(0):589-591, Surgical forum
— id: 98811, year: 1994, vol: 45, page: 589, stat: Journal Article,

Neutrophil chemotaxis in response to TGF-beta isoforms (TGF-beta 1, TGF-beta 2, TGF-beta 3) is mediated by fibronectin
Parekh T; Saxena B; Reibman J; Cronstein BN; Gold LI
1994 Mar 1;152(5):2456-2466, Journal of immunology (1950)
— id: 6480, year: 1994, vol: 152, page: 2456, stat: Journal Article,

Expression of transforming growth factor-beta mRNAs and proteins in pulmonary vascular remodeling in the sheep air embolization model of pulmonary hypertension
Perkett, E A; Pelton, R W; Meyrick, B; Gold, L I; Miller, D A
1994 Jul;11(1):16-24, American journal of respiratory cell & molecular biology
— id: 76309, year: 1994, vol: 11, page: 16, stat: Journal Article,

Further characterization of the NH2-terminal fibrin-binding site on fibronectin
Rostagno A; Williams MJ; Baron M; Campbell ID; Gold LI
1994 Dec 16;269(50):31938-31945, Journal of biological chemistry
— id: 6734, year: 1994, vol: 269, page: 31938, stat: Journal Article,

Expression of transforming growth factor-beta 1 and -beta 2 in human papillomavirus (HPV)-associated lesions of the uterine cervix
Tervahauta, A; Syrjanen, S; Yliskoski, M; Gold, L I; Syrjanen, K
1994 Sep;54(3):349-356, Gynecologic oncology
— id: 76308, year: 1994, vol: 54, page: 349, stat: Journal Article,

Localization of transforming growth factor beta isoforms in the normal murine small intestine and colon
Barnard, J A; Warwick, G J; Gold, L I
1993 Jul;105(1):67-73, Gastroenterology
— id: 76316, year: 1993, vol: 105, page: 67, stat: Journal Article,

Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
Friess, H; Yamanaka, Y; Buchler, M; Ebert, M; Beger, H G; Gold, L I; Korc, M
1993 Dec;105(6):1846-1856, Gastroenterology
— id: 76314, year: 1993, vol: 105, page: 1846, stat: Journal Article,

Further characterization of the binding of fibronectin to gelatin reveals the presence of different binding interactions
Garcia-Pardo, A; Gold, L I
1993 Jul;304(1):181-188, Archives of biochemistry & biophysics. ABB
— id: 76317, year: 1993, vol: 304, page: 181, stat: Journal Article,

Chemoattraction of neutrophils by substance P and transforming growth factor-beta 1 is inadequately explained by current models of lipid remodeling
Haines KA; Kolasinski SL; Cronstein BN; Reibman J; Gold LI; Weissmann G
1993 Aug 1;151(3):1491-1499, Journal of immunology (1950)
— id: 9821, year: 1993, vol: 151, page: 1491, stat: Journal Article,

Transforming growth factor-beta in neural embryogenesis and neoplasia
Johnson, M D; Jennings, M T; Gold, L I; Moses, H L
1993 May;24(5):457-462, Human pathology
— id: 76319, year: 1993, vol: 24, page: 457, stat: Journal Article,

Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair
Levine, J H; Moses, H L; Gold, L I; Nanney, L B
1993 Aug;143(2):368-380, American journal of pathology
— id: 76315, year: 1993, vol: 143, page: 368, stat: Journal Article,

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia
Nabel, E G; Shum, L; Pompili, V J; Yang, Z Y; San, H; Shu, H B; Liptay, S; Gold, L; Gordon, D; Derynck, R
1993 Nov;90(22):10759-10763, Proceedings of the National Academy of Sciences of the United States of America
— id: 163343, year: 1993, vol: 90, page: 10759, stat: Journal Article,

DIRECT TRANSFER OF TRANSFORMING GROWTH-FACTOR-BETA-1 GENE INTO ARTERIES STIMULATES FIBROCELLULAR HYPERPLASIA
NABEL, EG; SHUM, L; POMPILI, VJ; YANG, ZY; SAN, H; SHU, HB; LIPTAY, S; GOLD, L; GORDON, D; DERYNCK, R; NABEL, GJ
1993 NOV 15 ;90(22):10759-10763, Proceedings of the National Academy of Sciences of the United States of America
— id: 98458, year: 1993, vol: 90, page: 10759, stat: Journal Article,

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1
Pierce, D F Jr; Johnson, M D; Matsui, Y; Robinson, S D; Gold, L I; Purchio, A F; Daniel, C W; Hogan, B L; Moses, H L
1993 Dec;7(12A):2308-2317, Genes & development
— id: 76313, year: 1993, vol: 7, page: 2308, stat: Journal Article,

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor
Santambrogio L; Hochwald GM; Saxena B; Leu CH; Martz JE; Carlino JA; Ruddle NH; Palladino MA; Gold LI; Thorbecke GJ
1993 Jul 15;151(2):1116-1127, Journal of immunology (1950)
— id: 8728, year: 1993, vol: 151, page: 1116, stat: Journal Article,

Synthesis and expression of transforming growth factor beta-1, beta-2, and beta-3 in the endocrine and exocrine pancreas
Yamanaka, Y; Friess, H; Buchler, M; Beger, H G; Gold, L I; Korc, M
1993 May;42(5):746-756, Diabetes
— id: 76318, year: 1993, vol: 42, page: 746, stat: Journal Article,

Localization of the cleavage sites on fibronectin following digestion by urokinase
Gold LI; Rostagno A; Frangione B; Passalaris T
1992 Dec;50(4):441-452, Journal of cellular biochemistry
— id: 9532, year: 1992, vol: 50, page: 441, stat: Journal Article,

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer
Gorsch, S M; Memoli, V A; Stukel, T A; Gold, L I; Arrick, B A
1992 Dec 15;52(24):6949-6952, Cancer research
— id: 76320, year: 1992, vol: 52, page: 6949, stat: Journal Article,

Transforming growth factor-beta and transforming growth factor beta-receptor expression in human meningioma cells
Johnson MD; Federspiel CF; Gold LI; Moses HL
1992 Sep;141(3):633-642, American journal of pathology
— id: 63198, year: 1992, vol: 141, page: 633, stat: Journal Article,

Evidence for transforming growth factor-beta expression in human leptomeningeal cells and transforming growth factor-beta-like activity in human cerebrospinal fluid
Johnson MD; Gold LI; Moses HL
1992 Sep;67(3):360-368, Laboratory investigation
— id: 62336, year: 1992, vol: 67, page: 360, stat: Journal Article,

Effect of topical retinoic acids on the levels of collagen mRNA during the repair of UVB-induced dermal damage in the hairless mouse and the possible role of TGF-beta as a mediator
Kim, H J; Bogdan, N J; D'Agostaro, L J; Gold, L I; Bryce, G F
1992 Mar;98(3):359-363, Journal of investigative dermatology
— id: 76321, year: 1992, vol: 98, page: 359, stat: Journal Article,

FURTHER LOCALIZATION OF THE TWO BINDING SITES FOR FIBRIN WITHIN FIBRONECTIN
GOLD L; ROSTAGNO A
1991 ;17(15 PART F):180-180, Journal of cellular biochemistry. Supplement
— id: 101624, year: 1991, vol: 17, page: 180, stat: Journal Article,

Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 mRNA and protein in the murine lung
Pelton, R W; Johnson, M D; Perkett, E A; Gold, L I; Moses, H L
1991 Dec;5(6):522-530, American journal of respiratory cell & molecular biology
— id: 76322, year: 1991, vol: 5, page: 522, stat: Journal Article,

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development
Pelton, R W; Saxena, B; Jones, M; Moses, H L; Gold, L I
1991 Nov;115(4):1091-1105, Journal of cell biology
— id: 76323, year: 1991, vol: 115, page: 1091, stat: Journal Article,

Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways
Reibman J; Meixler S; Lee TC; Gold LI; Cronstein BN; Haines KA; Kolasinski SL; Weissmann G
1991 Aug 1;88(15):6805-6809, Proceedings of the National Academy of Sciences of the United States of America
— id: 9831, year: 1991, vol: 88, page: 6805, stat: Journal Article,

Biochemical studies on the interaction of fibronectin with Ig
Rostagno AA; Frangione B; Gold L
1991 Apr 15;146(8):2687-2693, Journal of immunology (1950)
— id: 9547, year: 1991, vol: 146, page: 2687, stat: Journal Article,

TRANSFORMING GROWTH FACTOR-BETA-1 - THE MOST POTENT CHEMOATTRACTANT FOR HUMAN NEUTROPHILS (PMN)
Reibman, J; Meixler, SM; Lee, TC; Cronstein, BN; Gold, LI; Weissmann, G
1990 Apr;38(2):A406-A406, Clinical research
— id: 31965, year: 1990, vol: 38, page: A406, stat: Journal Article,

Human plasma fibronectin as a substrate for human urokinase
Gold LI; Schwimmer R; Quigley JP
1989 Sep 1;262(2):529-534, Biochemical journal
— id: 10517, year: 1989, vol: 262, page: 529, stat: Journal Article,

Biochemical characterization of the fibronectin binding sites for IgG
Rostagno AA; Frangione B; Gold LI
1989 Nov 15;143(10):3277-3282, Journal of immunology (1950)
— id: 9560, year: 1989, vol: 143, page: 3277, stat: Journal Article,

BIOCHEMICAL CHARACTERIZATION OF UROKINASE PROTEOLYTIC CLEAVAGE OF FIBRONECTIN
GOLD L I; ROSTAGNO A; PASSALARIS T
1988 ;107(6 PART 3):373A-373A, Journal of cell biology
— id: 101625, year: 1988, vol: 107, page: 373A, stat: Journal Article,

FIBRONECTIN IGG INTERACTION CHARACTERIZATION OF THE BINDING SITES IN FIBRONECTIN MOLECULE
ROSTAGNO A; FRANGIONE B; GOLD L I
1988 ;107(6 PART 3):599A-599A, Journal of cell biology
— id: 101626, year: 1988, vol: 107, page: 599A, stat: Journal Article,

Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells
Quigley, J P; Gold, L I; Schwimmer, R; Sullivan, L M
1987 May;84(9):2776-2780, Proceedings of the National Academy of Sciences of the United States of America
— id: 76324, year: 1987, vol: 84, page: 2776, stat: Journal Article,

Biochemical and immunological characterization of three binding sites on human plasma fibronectin with different affinities for heparin
Gold LI; Frangione B; Pearlstein E
1983 Aug 16;22(17):4113-4119, Biochemistry
— id: 9620, year: 1983, vol: 22, page: 4113, stat: Journal Article,

HUMAN-PLASMA FIBRONECTIN (FN) BINDING DOMAINS FOR COLLAGEN, HEPARIN, AND FIBRIN LOCALIZED BY AMINO-ACID-SEQUENCE DETERMINATION
Gold, LI; Frangione, B; Pearlstein, E
1982 ;95(2):A127-A127, Journal of cell biology
— id: 30349, year: 1982, vol: 95, page: A127, stat: Journal Article,

LOCALIZATION AND BIOCHEMICAL-CHARACTERIZATION OF THE COLLAGEN, FIBRIN AND HEPARIN-BINDING DOMAINS OF FIBRONECTIN (FN)
Gold, LI; Pearlstein, E; Franklin, EC; Frangione, B
1981 ;91(2):A164-A164, Journal of cell biology
— id: 30404, year: 1981, vol: 91, page: A164, stat: Journal Article,

Fibronectin-collagen binding and requirement during cellular adhesion
Gold LI; Pearlstein E
1980 Feb 15;186(2):551-559, Biochemical journal
— id: 64086, year: 1980, vol: 186, page: 551, stat: Journal Article,

Fibronectin: a review of its structure and biological activity
Pearlstein E; Gold LI; Garcia-Pardo A
1980 Feb 8;29(2):103-128, Molecular & cellular biochemistry
— id: 64087, year: 1980, vol: 29, page: 103, stat: Journal Article,

Subtilisin and cyanogen bromide cleavage products of fibronectin that retain gelatin-binding activity
Gold LI; Garcia-Pardo A; Frangione B; Franklin EC; Pearlstein E
1979 Oct;76(10):4803-4807, Proceedings of the National Academy of Sciences of the United States of America
— id: 9650, year: 1979, vol: 76, page: 4803, stat: Journal Article,

Stability of fibronectin biological activity following chemical modification
Gold LI; Pearlstein E
1979 Dec 14;581(2):237-251, Biochimica & biophysica acta
— id: 64084, year: 1979, vol: 581, page: 237, stat: Journal Article,

Functional and structural studies in fibronectin
Gold, Leslie I
[S.l. : s.n.], 1979,
— id: 1045, year: 1979, vol: , page: , stat: ,

EXPRESSION OF MOUSE AND HUMAN FIBRONECTIN IN HYBRID-CELLS
Smith, M; Gold, LI; Pearlstein, E; Krinsky, A
1979 ;25(1-4):205-205, Cytogenetics & cell genetics
— id: 28003, year: 1979, vol: 25, page: 205, stat: Journal Article,

High-molecular-weight glycorprotein as a mediator of cellular adhesion
Pearlstein E; Gold LI
1978 Jun 20;312:278-292, Annals of the New York Academy of Sciences
— id: 64085, year: 1978, vol: 312, page: 278, stat: Journal Article,

CYANOGEN-BROMIDE FRAGMENT OF FIBRONECTIN WHICH RETAINS COLLAGEN BINDING-SITE
Pearlstein, E; Garciapardo, A; Gold, LI
1978 ;79(2):A228-A228, Journal of cell biology
— id: 29760, year: 1978, vol: 79, page: A228, stat: Journal Article,