Biosketch / Results /
Dorothy FriedbergClinical Professor, Department of Ophthalmology
462 First Avenue
New York, NY 10016
Education1975-1978 — Montefiore Medical Center (Ophthalmology), Residency Training
Research SummaryDorothy N. Friedberg, M.D., Ph.D. is currently involved in clinical research on the ocular complications of AIDS. As part of this work Dr. Friedberg and her co-investigators are participating in several national multicenter protocols sponsored by industry and by the National Eye Institute. These projects are investigating medications for the treatment of Cytomegalovirus (CMV) retinitis which if untreated can produce retinal destruction and blindness. Dr. Friedberg is also studying the intraocular pressure in HIV-infected patients without obvious eye disease in an attempt to understand the etiology of the reported low pressures in this group of patients.
The investigators have done some preliminary electrophysiological evaluations in HIV-infected patients. Even in patients without retinitis or retinal microangiopathy there are abnormalities in both the ERG and dark adaption. Dr. Friedberg and her co-investigators are planning to expand these studies to include evaluation of long term non progressors, patients infected with HIV who do not go on to develop AIDS at the usual rate. A strong commitment to basic ophthalmic research will allow them to expand the scope of investigations.
The investigators are currently working with several opthamologists to develop an ocular HIV study group to facilitate communications between opthamologists both in the US and abroad who are involved in patient care and/or research in ocular HIV.
Research InterestsOcular Complications of AIDS
Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis
Kempen, John H; Min, Yuan-I; Freeman, William R; Holland, Gary N; Friedberg, Dorothy N; Dieterich, Douglas T; Jabs, Douglas A. Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis. Ophthalmology. 2006 Apr ;113(4):684-694 (96106)
Friedberg DN; Lorenzo-Latkany M. Ocular complications IN: Tuberculosis. Philadelphia : Lippincott Williams & Wilkins, 2004 2nd ed.. p.465-476 (3971)
High dose oral ganciclovir treatment for cytomegalovirus retinitis
Lalezari, Jacob P; Friedberg, Dorothy N; Bissett, Jack; Giordano, Michael F; Hardy, W David; Drew, W Lawrence; Hubbard, Larry D; Buhles, William C; Stempien, Mary Jean; Georgiou, Panos; Jung, Donald T; Robinson, Charles A. High dose oral ganciclovir treatment for cytomegalovirus retinitis. Journal of clinical virology. 2002 Feb ;24(1-2):67-77 (96107)
A safety study of oral valganciclovir maintenance treatment of cytomegalovirus retinitis
Lalezari, Jacob; Lindley, Janette; Walmsley, Sharon; Kuppermann, Baruch; Fisher, Martin; Friedberg, Dorothy; Lalonde, Richard; Matheron, Sophie; Nieto, Leopoldo; Torriani, Francesca J; Van Syoc, Rod; Sutton, Mary Ann; Buhles, William; Stempien, Mary Jean. A safety study of oral valganciclovir maintenance treatment of cytomegalovirus retinitis. Journal of acquired immune deficiency syndromes. JAIDS. 2002 Aug 1;30(4):392-400 (741572)
Long-term follow-up of patients with AIDS treated with parenteral cidofovir for cytomegalovirus retinitis: the HPMPC Peripheral Cytomegalovirus Retinitis Trial - The Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group
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