David E Levy

Biosketch / Results /

David E Levy, Ph.D.

Dr. Louis A. Schneider Professor of Molecular Pathology; Professor; Assoc Director Perlmutter Cancer Center; Dir Molecular Onc & Immunology Grad/PstDoc Trng Pg; Assoc Dean Collaborative Science
Departments of Pathology (Pathology) and Microbiology (Microbiology )

Contact Info

550 First Avenue
Dept. of Pathology Floor 5 Room 538/548
Medical Science Building
New York, NY 10016

212-263-8192, 212-263-1494
509-757-3029, 212-263-8211

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— Dr. Levy was awarded a NIH Postdoctoral Fellowship for the period 1984-87 which was spent at the Lab of Molecular Cell Biology at the Rockefeller University, PostDoctoral Training
1985 — Molecular Biology from the California Institute of Technology, Pasadena, CA, Graduate Education

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All data from NYU Health Sciences Library Faculty Bibliography — -


STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation
Gough, Daniel J; Marie, Isabelle J; Lobry, Camille; Aifantis, Iannis; Levy, David E
2014 Oct;124(14):2252-2261, Blood
— id: 1298802, year: 2014, vol: 124, page: 2252, stat: Journal Article,

The human RVB complex is required for efficient transcription of type I interferon-stimulated genes
Gnatovskiy, Leonid; Mita, Paolo; Levy, David E
2013 Oct;33(19):3817-3825, Molecular & cellular biology
— id: 575612, year: 2013, vol: 33, page: 3817, stat: Journal Article,

Mitochondrial STAT3 supports K-Ras driven myeloid leukaemia in vivo
Gough, Daniel J.; Levy, David E.
2013 SEP;63(3):266-267, Cytokine
— id: 557542, year: 2013, vol: 63, page: 266, stat: Journal Article,

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
Gough, Daniel J; Koetz, Lisa; Levy, David E
2013 ;8(11):e83395-e83395 e83395, PLoS one
— id: 681112, year: 2013, vol: 8, page: e83395, stat: Journal Article,

STAT1-deficient mice spontaneously develop estrogen receptor alpha-positive luminal mammary carcinomas
Chan, Szeman Ruby; Vermi, William; Luo, Jingqin; Lucini, Laura; Rickert, Charles; Fowler, Amy M.; Lonardi, Silvia; Arthur, Cora; Young, Larry J. T.; Levy, David E.; Welch, Michael J.; Cardiff, Robert D.; Schreiber, Robert D.
2012 ;14(1):-, Breast cancer research
— id: 178169, year: 2012, vol: 14, page: , stat: Journal Article,

Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN-gamma-Induced Gene Expression
Farlik, Matthias; Rapp, Birgit; Marie, Isabelle; Levy, David E; Jamieson, Amanda M; Decker, Thomas
2012 Mar;32(6):1032-1043, Molecular & cellular biology
— id: 160243, year: 2012, vol: 32, page: 1032, stat: Journal Article,

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling
Gough, Daniel J; Messina, Nicole L; Clarke, Christopher J P; Johnstone, Ricky W; Levy, David E
2012 Feb;36(2):166-174, Immunity
— id: 158280, year: 2012, vol: 36, page: 166, stat: Journal Article,

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function
Lee, J E; Yang, Y -M; Liang, F -X; Gough, D J; Levy, D E; Sehgal, P B
2012 March 2012;302(5):804-820, American journal of physiology. Cell physiology
— id: 161210, year: 2012, vol: 302, page: 804, stat: Journal Article,

STATus Report on Tetramers
Levy, David E; Marie, Isabelle J
2012 Apr;36(4):553-555, Immunity
— id: 165619, year: 2012, vol: 36, page: 553, stat: Journal Article,

Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface
Nancy, Patrice; Tagliani, Elisa; Tay, Chin-Siean; Asp, Patrik; Levy, David E; Erlebacher, Adrian
2012 Jun;336(6086):1317-1321, Science
— id: 169515, year: 2012, vol: 336, page: 1317, stat: Journal Article,

Comparative evolutionary genomics of the STAT family of transcription factors
Wang, Yaming; Levy, David E
2012 Jan;1(1):23-33, JAK-STAT
— id: 1051522, year: 2012, vol: 1, page: 23, stat: Journal Article,

A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh
Wu, F; Chen, Y; Liu, M L; Parvez, F; Slavkovich, V; Eunus, M; Ahmed, A; Segers, S; Argos, M; Islam, T; Rakibuz-Zaman, M; Hasan, R; Sarwar, G; Levy, D; Graziano, J H; Ahsan, H
2012 15 Jun 2012;175:S138-S138, American journal of epidemiology
— id: 174160, year: 2012, vol: 175, page: S138, stat: Journal Article,

Association between arsenic exposure from drinking water and electrocardiographic abnormality of heart rate-corrected QT-interval prolongation: Results from the health effects of arsenic longitudinal study
Wu, F; Chen, Y; Parvez, F; Ahmed, A; Eunus, M; McClintock, T R; Patwary, T I; Islam, T; Ghosal, A K; Islam, S; Hasan, R; Levy, D; Sarwar, G; Slavkovich, V; Van, Geen A; Graziano, J H; Ahsan, H
2012 15 Jun 2012;175:S8-S8, American journal of epidemiology
— id: 174161, year: 2012, vol: 175, page: S8, stat: Journal Article,

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
Zhang, Liang; Das, Priyabrata; Schmolke, Mirco; Manicassamy, Balaji; Wang, Yaming; Deng, Xiaoyi; Cai, Ling; Tu, Benjamin P; Forst, Christian V; Roth, Michael G; Levy, David E; Garcia-Sastre, Adolfo; de Brabander, Jef; Phillips, Margaret A; Fontoura, Beatriz M A
2012 Feb;196(3):315-326, Journal of cell biology
— id: 158676, year: 2012, vol: 196, page: 315, stat: Journal Article,

TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10-Mediated Suppression of Antitumor Immunity
Bogunovic, Dusan; Manches, Olivier; Godefroy, Emmanuelle; Yewdall, Alice; Gallois, Anne; Salazar, Andres M; Marie, Isabelle; Levy, David E; Bhardwaj, Nina
2011 Aug 15;71(16):5467-5476, Cancer research
— id: 136637, year: 2011, vol: 71, page: 5467, stat: Journal Article,

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
Corcoran, Ryan B; Contino, Gianmarco; Deshpande, Vikram; Tzatsos, Alexandros; Conrad, Claudius; Benes, Cyril H; Levy, David E; Settleman, Jeffrey; Engelman, Jeffrey A; Bardeesy, Nabeel
2011 Jul 15;71(14):5020-5029, Cancer research
— id: 135540, year: 2011, vol: 71, page: 5020, stat: Journal Article,

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis
Kaplan, Mark H; Glosson, Nicole L; Stritesky, Gretta L; Yeh, Norman; Kinzfogl, John; Rohrabaugh, Sara L; Goswami, Ritobrata; Pham, Duy; Levy, David E; Brutkiewicz, Randy R; Blum, Janice S; Cooper, Scott; Hangoc, Giao; Broxmeyer, Hal E
2011 Jun 9;117(23):6198-6201, Blood
— id: 141123, year: 2011, vol: 117, page: 6198, stat: Journal Article,

Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of foxp3 expression and treg function
Lal, G; Yin, N; Xu, J; Lin, M; Schroppel, S; Ding, Y; Marie, I; Levy, D E; Bromberg, J S
2011 Feb;11(2):203-214, American journal of transplantation
— id: 122535, year: 2011, vol: 11, page: 203, stat: Journal Article,

Induction and function of type I and III interferon in response to viral infection
Levy, David E; Marie, Isabelle J; Durbin, Joan E
2011 Dec;1(6):476-486, Current opinion in virology
— id: 166500, year: 2011, vol: 1, page: 476, stat: Journal Article,

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype
O'Brien, Meagan; Manches, Olivier; Sabado, Rachel Lubong; Baranda, Sonia Jimenez; Wang, Yaming; Marie, Isabelle; Rolnitzky, Linda; Markowitz, Martin; Margolis, David M; Levy, David; Bhardwaj, Nina
2011 Mar 1;121(3):1088-1101, Journal of clinical investigation
— id: 130297, year: 2011, vol: 121, page: 1088, stat: Journal Article,

The transcription factor STAT3 is required for T helper 2 cell development
Stritesky, Gretta L; Muthukrishnan, Rajarajeswari; Sehra, Sarita; Goswami, Ritobrata; Pham, Duy; Travers, Jared; Nguyen, Evelyn T; Levy, David E; Kaplan, Mark H
2011 Jan 28;34(1):39-49, Immunity
— id: 132218, year: 2011, vol: 34, page: 39, stat: Journal Article,

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
Wang, Ding; Zavadil, Jiri; Martin, Leenus; Parisi, Fabio; Friedman, Eugene; Levy, David; Harding, Heather; Ron, David; Gardner, Lawrence B
2011 Sep;31(17):3670-3680, Molecular & cellular biology
— id: 136513, year: 2011, vol: 31, page: 3670, stat: Journal Article,

STAT3 negatively regulates type I IFN-mediated antiviral response
Wang, Wei-Bei; Levy, David E; Lee, Chien-Kuo
2011 Sep 1;187(5):2578-2585, Journal of immunology
— id: 138428, year: 2011, vol: 187, page: 2578, stat: Journal Article,

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
Demaria, Marco; Giorgi, Carlotta; Lebiedzinska, Magdalena; Esposito, Giovanna; D'Angeli, Luca; Bartoli, Antonietta; Gough, Daniel J; Turkson, James; Levy, David E; Watson, Christine J; Wieckowski, Mariusz R; Provero, Paolo; Pinton, Paolo; Poli, Valeria
2010 Nov;2(11):823-842, Aging
— id: 134403, year: 2010, vol: 2, page: 823, stat: Journal Article,

Functional crosstalk between type I and II interferon through the regulated expression of STAT1
Gough, Daniel J; Messina, Nicole L; Hii, Linda; Gould, Jodee A; Sabapathy, Kanaga; Robertson, Ashley P S; Trapani, Joseph A; Levy, David E; Hertzog, Paul J; Clarke, Christopher J P; Johnstone, Ricky W
2010 ;8(4):e1000361-e1000361, PLoS biology
— id: 138944, year: 2010, vol: 8, page: e1000361, stat: Journal Article,

Non-canonical functions of STAT3 in growth and tumorigenesis
Gough, Daniel; Jones, Courtney; Wang, Yaming; Marie, Isabelle; Levy, David E.
2010 OCT-NOV ;52(1-2):36-36, Cytokine
— id: 113933, year: 2010, vol: 52, page: 36, stat: Journal Article,

NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip?
Levy, David E
2010 Jul 23;33(1):1-2, Immunity
— id: 111362, year: 2010, vol: 33, page: 1, stat: Journal Article,

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Manel, Nicolas; Hogstad, Brandon; Wang, Yaming; Levy, David E; Unutmaz, Derya; Littman, Dan R
2010 Sep 9;467(7312):214-217, Nature
— id: 112431, year: 2010, vol: 467, page: 214, stat: Journal Article,

STAT3 negatively regulates type I IFN-mediated signaling and functions
Wang, Wei-Bei; Den, Hao-Kang; Levy, David E.; Lee, Chien-Kuo
2010 OCT-NOV ;52(1-2):65-65, Cytokine
— id: 113935, year: 2010, vol: 52, page: 65, stat: Journal Article,

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation
Gough, Daniel J; Corlett, Alicia; Schlessinger, Karni; Wegrzyn, Joanna; Larner, Andrew C; Levy, David E
2009 Jun 26;324(5935):1713-1716, Science
— id: 100615, year: 2009, vol: 324, page: 1713, stat: Journal Article,

Activation of Stat3 in renal tumors
Guo, Charles; Yang, Guanyu; Khun, Kyle; Kong, Xiantian; Levy, David; Lee, Peng; Melamed, Jonathan
2009 ;1(3):283-290, American journal of translational research
— id: 105529, year: 2009, vol: 1, page: 283, stat: Journal Article,

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
Kwon, Hyokjoon; Thierry-Mieg, Danielle; Thierry-Mieg, Jean; Kim, Hyoung-Pyo; Oh, Jangsuk; Tunyaplin, Chainarong; Carotta, Sebastian; Donovan, Colleen E; Goldman, Matthew L; Tailor, Prafullakumar; Ozato, Keiko; Levy, David E; Nutt, Stephen L; Calame, Kathryn; Leonard, Warren J
2009 Dec 18;31(6):941-952, Immunity
— id: 138943, year: 2009, vol: 31, page: 941, stat: Journal Article,

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
Lal, Girdhari; Zhang, Nan; van der Touw, William; Ding, Yaozhong; Ju, Wenjun; Bottinger, Erwin P; Reid, St Patrick; Levy, David E; Bromberg, Jonathan S
2009 Jan 1;182(1):259-273, Journal of immunology
— id: 93449, year: 2009, vol: 182, page: 259, stat: Journal Article,

Ancrod for acute ischemic stroke: a new dosing regimen derived from analysis of prior ancrod stroke studies
Levy, David E; Trammel, James; Wasiewski, Warren W
2009 Jan;18(1):23-27, Journal of stroke & cerebrovascular diseases
— id: 93448, year: 2009, vol: 18, page: 23, stat: Journal Article,

Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy
Lu, Ting-Chi; Wang, Zhao-Hui; Feng, Xiaobei; Chuang, Peter Y; Fang, Wei; Shen, Yuhong; Levy, David E; Xiong, Huabao; Chen, Nan; He, John Cijiang
2009 Jul;76(1):63-71, Kidney international
— id: 138970, year: 2009, vol: 76, page: 63, stat: Journal Article,

Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells
O'Malley, John T; Sehra, Sarita; Thieu, Vivian T; Yu, Qing; Chang, Hua-Chen; Stritesky, Gretta L; Nguyen, Evelyn T; Mathur, Anubhav N; Levy, David E; Kaplan, Mark H
2009 Aug;127(4):587-595, Immunology
— id: 132219, year: 2009, vol: 127, page: 587, stat: Journal Article,

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression
Ranger, Jill J; Levy, David E; Shahalizadeh, Solmaz; Hallett, Michael; Muller, William J
2009 Sep 1;69(17):6823-6830, Cancer research
— id: 138942, year: 2009, vol: 69, page: 6823, stat: Journal Article,

IL-21 mediates suppressive effects via its induction of IL-10
Spolski, Rosanne; Kim, Hyoung-Pyo; Zhu, Wei; Levy, David E; Leonard, Warren J
2009 Mar 1;182(5):2859-2867, Journal of immunology
— id: 93447, year: 2009, vol: 182, page: 2859, stat: Journal Article,

Analysis of chikungunya viral protein interactions with the interferon response pathway
Tangeman, M; Briese, T; Lipkin, WI; Levy, DE
2009 OCT-NOV ;48(1-2):60-60, Cytokine
— id: 105955, year: 2009, vol: 48, page: 60, stat: Journal Article,

c-Maf regulates IL-10 expression during Th17 polarization
Xu, Jiangnan; Yang, Yu; Qiu, Guixing; Lal, Girdhari; Wu, Zhihong; Levy, David E; Ochando, Jordi C; Bromberg, Jonathan S; Ding, Yaozhong
2009 May 15;182(10):6226-6236, Journal of immunology
— id: 138941, year: 2009, vol: 182, page: 6226, stat: Journal Article,

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
Bonni, Azad; Depinho, Ronald A; Levy, David E; You, Mingjian J; Bachoo, Robert M; Chan, Jennifer A; Puram, Sidharth V; Konopka, Genevieve; de la Iglesia, Nuria
2008 Feb 15;22(4):449-462, Genes & development
— id: 93452, year: 2008, vol: 22, page: 449, stat: Journal Article,

Nucleoporin levels regulate cell cycle progression and phase-specific gene expression
Chakraborty, Papia; Wang, Yaming; Wei, Jen-Hsuan; van Deursen, Jan; Yu, Hongtao; Malureanu, Liviu; Dasso, Mary; Forbes, Douglass J; Levy, David E; Seemann, Joachim; Fontoura, Beatriz M A
2008 Nov;15(5):657-667, Developmental cell
— id: 93450, year: 2008, vol: 15, page: 657, stat: Journal Article,

Vaccinia virus protein E3L inhibits type I interferon induction by the cytoplasmic signaling pathway
Friedman, E; Marie, IJ; Levy, DE
2008 SEP ;43(3):300-301, Cytokine
— id: 91472, year: 2008, vol: 43, page: 300, stat: Journal Article,

IFNgamma signaling-does it mean JAK-STAT?
Gough, Daniel J; Levy, David E; Johnstone, Ricky W; Clarke, Christopher J
2008 Oct-Dec;19(5-6):383-394, Cytokine & growth factor reviews
— id: 93451, year: 2008, vol: 19, page: 383, stat: Journal Article,

Monocytes in the urine of children with lupus: A potential marker of active nephritis
Kahn, PJ; Zhang, HZ; Levy, D; Imundo, L; Eichenfield, A; Winchestet, R
2008 ;58(9):S252-S252, Arthritis & rheumatism
— id: 90034, year: 2008, vol: 58, page: S252, stat: Journal Article,

Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3
Joo, Chul Hyun; Shin, Young C; Gack, Michaela; Wu, Liguo; Levy, David; Jung, Jae U
2007 Aug;81(15):8282-8292, Journal of virology
— id: 138972, year: 2007, vol: 81, page: 8282, stat: Journal Article,

STAT3 signaling and the hyper-IgE syndrome
Levy, David E; Loomis, Cynthia A
2007 Oct 18;357(16):1655-1658, New England journal of medicine
— id: 93454, year: 2007, vol: 357, page: 1655, stat: Journal Article,

The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses
MacDonald, Margaret R; Machlin, Erica S; Albin, Owen R; Levy, David E
2007 Dec;81(24):13509-13518, Journal of virology
— id: 93453, year: 2007, vol: 81, page: 13509, stat: Journal Article,

Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling
Mahajan, Muktar A; Murray, Audrey; Levy, David; Samuels, Herbert H
2007 Aug;21(8):1822-1834, Molecular endocrinology
— id: 73864, year: 2007, vol: 21, page: 1822, stat: Journal Article,

Stat3 and Stat4 direct development of IL-17-secreting Th cells
Mathur, Anubhav N; Chang, Hua-Chen; Zisoulis, Dimitrios G; Stritesky, Gretta L; Yu, Qing; O'Malley, John T; Kapur, Reuben; Levy, David E; Kansas, Geoffrey S; Kaplan, Mark H
2007 Apr 15;178(8):4901-4907, Journal of immunology
— id: 93456, year: 2007, vol: 178, page: 4901, stat: Journal Article,

Influenza virus targets the mRNA export machinery and the nuclear pore complex
Satterly, Neal; Tsai, Pei-Ling; van Deursen, Jan; Nussenzveig, Daniel R; Wang, Yaming; Faria, Paula A; Levay, Agata; Levy, David E; Fontoura, Beatriz M A
2007 Feb 6;104(6):1853-1858, Proceedings of the National Academy of Sciences of the United States of America
— id: 93457, year: 2007, vol: 104, page: 1853, stat: Journal Article,

JAK-STAT signaling: from interferons to cytokines
Schindler, Christian; Levy, David E; Decker, Thomas
2007 Jul 13;282(28):20059-20063, Journal of biological chemistry
— id: 93455, year: 2007, vol: 282, page: 20059, stat: Journal Article,

Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity
Tseng, J-C; Zheng, Y; Yee, H; Levy, D E; Meruelo, D
2007 Aug;14(15):1166-1174, Gene therapy
— id: 74661, year: 2007, vol: 14, page: 1166, stat: Journal Article,

Multiple signaling pathways are involved in IL-21-mediated proliferation
Zeng, R; Spolski, R; Casas, E; Zhu, W; Levy, DE; Leonard, WJ
2007 JUL ;39(1):48-48, Cytokine
— id: 87204, year: 2007, vol: 39, page: 48, stat: Journal Article,

The molecular basis of IL-21-mediated proliferation
Zeng, Rong; Spolski, Rosanne; Casas, Esther; Zhu, Wei; Levy, David E; Leonard, Warren J
2007 May 15;109(10):4135-4142, Blood
— id: 93458, year: 2007, vol: 109, page: 4135, stat: Journal Article,

IL-6 programs TH-17 cell differentiation by promoting the sequential engagement of the IL-21 and IL-23 pathways
Zhou, L; Ivanov, II; Spolski, R; Min, R; Shenderov, K; Egawa, T; Levy, DE; Leonard, WJ; Littman, DR
2007 JUL ;39(1):49-49, Cytokine
— id: 87205, year: 2007, vol: 39, page: 49, stat: Journal Article,

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Zhou, Liang; Ivanov, Ivaylo I; Spolski, Rosanne; Min, Roy; Shenderov, Kevin; Egawa, Takeshi; Levy, David E; Leonard, Warren J; Littman, Dan R
2007 Sep;8(9):967-974, Nature immunology
— id: 74681, year: 2007, vol: 8, page: 967, stat: Journal Article,

STAT3 positively regulates an early step in B-cell development
Chou, Wei-Chun; Levy, David E; Lee, Chien-Kuo
2006 Nov 1;108(9):3005-3011, Blood
— id: 93462, year: 2006, vol: 108, page: 3005, stat: Journal Article,

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions
Faria, Ana M C; Levay, Agata; Wang, Yaming; Kamphorst, Alice O; Rosa, Magda L P; Nussenzveig, Daniel R; Balkan, Wayne; Chook, Yuh Min; Levy, David E; Fontoura, Beatriz M A
2006 Mar;24(3):295-304, Immunity
— id: 93464, year: 2006, vol: 24, page: 295, stat: Journal Article,

Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
Huang, Bo; Pan, Ping-Ying; Li, Qingsheng; Sato, Alice I; Levy, David E; Bromberg, Jonathan; Divino, Celia M; Chen, Shu-Hsia
2006 Jan 15;66(2):1123-1131, Cancer research
— id: 93465, year: 2006, vol: 66, page: 1123, stat: Journal Article,

STAT1 acts as a tumor promoter for leukemia development
Kovacic, Boris; Stoiber, Dagmar; Moriggl, Richard; Weisz, Eva; Ott, Rene G; Kreibich, Rita; Levy, David E; Beug, Hartmut; Freissmuth, Michael; Sexl, Veronika
2006 Jul;10(1):77-87, Cancer cell
— id: 93461, year: 2006, vol: 10, page: 77, stat: Journal Article,

STAT3: a multifaceted oncogene
Levy, David E; Inghirami, Giorgio
2006 Jul 5;103(27):10151-10152, Proceedings of the National Academy of Sciences of the United States of America
— id: 67388, year: 2006, vol: 103, page: 10151, stat: Journal Article,

Gemcitabine (G) plamsa and intracellular pharmacokinetics in E6201: Greater metabolite levels using fixed dosing rate (FDR) delivery
Liebes, L; Levy, DE; Poplin, E; Mendoza, S; Fry, D; Buckley, M; Zoloratov, A; Benson, A; Hochster, H
2006 JUN 20 ;24(18):85S-85S, Journal of clinical oncology
— id: 69295, year: 2006, vol: 24, page: 85S, stat: Journal Article,

Regulation of IRF7 through cell type-specific protein stability
Prakash, Arun; Levy, David E
2006 Mar 31;342(1):50-56, Biochemical & biophysical research communications
— id: 63740, year: 2006, vol: 342, page: 50, stat: Journal Article,

Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling
Sun, Wei; Snyder, Marylynn; Levy, David E; Zhang, J Jillian
2006 Oct 30;580(25):5880-5884, FEBS letters
— id: 93459, year: 2006, vol: 580, page: 5880, stat: Journal Article,

C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation
Wang, Yaming; Levy, David E
2006 Jan 10;16(1):89-94, Current biology. CB
— id: 62749, year: 2006, vol: 16, page: 89, stat: Journal Article,

C. elegans STAT: evolution of a regulatory switch
Wang, Yaming; Levy, David E
2006 Aug;20(10):1641-1652, FASEB journal
— id: 68775, year: 2006, vol: 20, page: 1641, stat: Journal Article,

Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR
Wang, Yaming; Zhu, Wei; Levy, David E
2006 Aug;39(4):356-362, Methods
— id: 93460, year: 2006, vol: 39, page: 356, stat: Journal Article,

An IL-21 receptor tyrosine is critical for IL-21-induced proliferation and the activation of Stat1 and Stat3
Zeng, R; Spolski, R; Casas, E; Levy, DE; Leonard, WJ
2006 APR 1 ;176(4):S14-S14, Journal of immunology
— id: 68834, year: 2006, vol: 176, page: S14, stat: Journal Article,

IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain
Zhang, Ling; Badgwell, Donna B; Bevers, Jack J 3rd; Schlessinger, Karni; Murray, Peter J; Levy, David E; Watowich, Stephanie S
2006 Aug;288(1-2):179-189, Molecular & cellular biochemistry
— id: 93463, year: 2006, vol: 288, page: 179, stat: Journal Article,

Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7
Caillaud, Alexandre; Hovanessian, Ara G; Levy, David E; Marie, Isabelle J
2005 May 6;280(18):17671-17677, Journal of biological chemistry
— id: 93468, year: 2005, vol: 280, page: 17671, stat: Journal Article,

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells
Gysemans, Conny A; Ladriere, Laurence; Callewaert, Hanne; Rasschaert, Joanne; Flamez, Daisy; Levy, David E; Matthys, Patrick; Eizirik, Decio L; Mathieu, Chantal
2005 Aug;54(8):2396-2403, Diabetes
— id: 93466, year: 2005, vol: 54, page: 2396, stat: Journal Article,

New and old functions of STAT3: a pivotal target for individualized treatment of cancer
Inghirami, Giorgio; Chiarle, Roberto; Simmons, William J; Piva, Roberto; Schlessinger, Karni; Levy, David E
2005 Sep;4(9):1131-1133, Cell cycle
— id: 64467, year: 2005, vol: 4, page: 1131, stat: Journal Article,

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons
Li, Yongzhong; Batra, Sandeep; Sassano, Antonella; Majchrzak, Beata; Levy, David E; Gaestel, Matthias; Fish, Eleanor N; Davis, Roger J; Platanias, Leonidas C
2005 Mar 18;280(11):10001-10010, Journal of biological chemistry
— id: 93471, year: 2005, vol: 280, page: 10001, stat: Journal Article,

Cell signaling. Stat acetylation--a key facet of cytokine signaling?
O'Shea, John J; Kanno, Yuka; Chen, Xiaomin; Levy, David E
2005 Jan 14;307(5707):217-218, Science
— id: 93470, year: 2005, vol: 307, page: 217, stat: Journal Article,

Reduced STAT3 activity in mice mimics clinical disease syndromes
Shen, Yuhong; La Perle, Krista M D; Levy, David E; Darnell, James E Jr
2005 Apr 29;330(1):305-309, Biochemical & biophysical research communications
— id: 93467, year: 2005, vol: 330, page: 305, stat: Journal Article,

Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1
Shi, Shuangping; Blumenthal, Antje; Hickey, Christopher M; Gandotra, Sheetal; Levy, David; Ehrt, Sabine
2005 Sep 1;175(5):3318-3328, Journal of immunology
— id: 138940, year: 2005, vol: 175, page: 3318, stat: Journal Article,

Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages
Tanaka, Naohiko; Hoshino, Yoshihiko; Gold, Jeffrey; Hoshino, Satomi; Martiniuk, Frank; Kurata, Takeshi; Pine, Richard; Levy, David; Rom, William N; Weiden, Michael
2005 Oct;33(4):406-411, American journal of respiratory cell & molecular biology
— id: 58745, year: 2005, vol: 33, page: 406, stat: Journal Article,

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
Yang, Jinbo; Chatterjee-Kishore, Moitreyee; Staugaitis, Susan M; Nguyen, Hannah; Schlessinger, Karni; Levy, David E; Stark, George R
2005 Feb 1;65(3):939-947, Cancer research
— id: 93469, year: 2005, vol: 65, page: 939, stat: Journal Article,

Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent
Chesler, David A; Dodard, Cindy; Lee, Grace Y; Levy, David E; Reiss, Carol Shoshkes
2004 Feb;10(1):57-63, Journal of neurovirology
— id: 42151, year: 2004, vol: 10, page: 57, stat: Journal Article,

Role of interferons in an in vivo model of inhalational anthrax
Gold JA; Jones MB; Levy DE; Hoshino Y; Nolan A; Weiden MD
2004 ;169:A230-A230, American journal of respiratory & critical care medicine
— id: 101401, year: 2004, vol: 169, page: A230, stat: Journal Article,

Art and the brain: the influence of art on Roger Shepard's studies of mental rotation
Levy, Ellen K; Levy, David E; Goldberg, Michael E
2004 Mar;13(1):79-90, Journal of the history of the neurosciences
— id: 93472, year: 2004, vol: 13, page: 79, stat: Journal Article,

Role of p38alpha Map kinase in Type I interferon signaling
Li, Yongzhong; Sassano, Antonella; Majchrzak, Beata; Deb, Dilip K; Levy, David E; Gaestel, Matthias; Nebreda, Angel R; Fish, Eleanor N; Platanias, Leonidas C
2004 Jan 9;279(2):970-979, Journal of biological chemistry
— id: 42152, year: 2004, vol: 279, page: 970, stat: Journal Article,

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation
Shen, Yuhong; Schlessinger, Karni; Zhu, Xuejun; Meffre, Eric; Quimby, Fred; Levy, David E; Darnell, J E Jr
2004 Jan;24(1):407-419, Molecular & cellular biology
— id: 93473, year: 2004, vol: 24, page: 407, stat: Journal Article,

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
Karaghiosoff, Marina; Steinborn, Ralf; Kovarik, Pavel; Kriegshauser, Gernot; Baccarini, Manuela; Donabauer, Birgit; Reichart, Ursula; Kolbe, Thomas; Bogdan, Christian; Leanderson, Tomas; Levy, David; Decker, Thomas; Muller, Mathias
2003 May;4(5):471-477, Nature immunology
— id: 650232, year: 2003, vol: 4, page: 471, stat: Journal Article,

Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity
Levy, David E; Marie, Isabelle; Prakash, Arun
2003 Feb;15(1):52-58, Current opinion in immunology
— id: 39347, year: 2003, vol: 15, page: 52, stat: Journal Article,

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth
Rankin, Erinn B; Yu, Duonan; Jiang, Jiu; Shen, Hao; Pearce, Edward J; Goldschmidt, Michael H; Levy, David E; Golovkina, Tatyana V; Hunter, Christopher A; Thomas-Tikhonenko, Andrei
2003 Nov-Dec;2(6):687-693, Cancer biology & therapy
— id: 42153, year: 2003, vol: 2, page: 687, stat: Journal Article,

The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex
Usacheva, Anna; Tian, Xinyong; Sandoval, Raudel; Salvi, Debra; Levy, David; Colamonici, Oscar R
2003 Sep 15;171(6):2989-2994, Journal of immunology
— id: 138939, year: 2003, vol: 171, page: 2989, stat: Journal Article,

STAT1 and STAT3 activation during the course of experimental arthritis
De Hooge, ASK; Van De Loo, FAJ; Kolbe, T; Mueller, M; Levy, DE; Bennink, M; Arntzl, OJ; Van Den Berg, WB
2002 SEP ;46(9):S250-S250, Arthritis & rheumatism
— id: 37120, year: 2002, vol: 46, page: S250, stat: Journal Article,

Role of nucleoporin induction in releasing an mRNA nuclear export block
Enninga, Jost; Levy, David E; Blobel, Gunter; Fontoura, Beatriz M A
2002 Feb 22;295(5559):1523-1525, Science
— id: 93477, year: 2002, vol: 295, page: 1523, stat: Journal Article,

Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli
Humphreys, Robin C; Bierie, Brian; Zhao, Ling; Raz, Regina; Levy, David; Hennighausen, Lothar
2002 Sep;143(9):3641-3650, Endocrinology
— id: 106996, year: 2002, vol: 143, page: 3641, stat: Journal Article,

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
Lee, Chien-kuo; Raz, Regina; Gimeno, Ramon; Gertner, Rachel; Wistinghausen, Birte; Takeshita, Kenichi; DePinho, Ronald A; Levy, David E
2002 Jul;17(1):63-72, Immunity
— id: 32457, year: 2002, vol: 17, page: 63, stat: Journal Article,

Whence interferon? Variety in the production of interferon in response to viral infection
Levy, David E
2002 Feb 18;195(4):F15-F18, Journal of experimental medicine
— id: 39705, year: 2002, vol: 195, page: F15, stat: Journal Article,

Stats: transcriptional control and biological impact
Levy, David E; Darnell, J E Jr
2002 Sep;3(9):651-662, Nature reviews. Molecular cell biology
— id: 39597, year: 2002, vol: 3, page: 651, stat: Journal Article,

What does Stat3 do?
Levy, David E; Lee, Chien-kuo
2002 May;109(9):1143-1148, Journal of clinical investigation
— id: 39652, year: 2002, vol: 109, page: 1143, stat: Journal Article,

Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback
Levy, David E; Marie, Isabelle; Smith, Eric; Prakash, Arun
2002 Jan;22(1):87-93, Journal of interferon & cytokine research
— id: 39713, year: 2002, vol: 22, page: 87, stat: Journal Article,

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff
Paulson, Matthew; Press, Carolyn; Smith, Eric; Tanese, Naoko; Levy, David E
2002 Feb;4(2):140-147, Nature cell biology
— id: 25648, year: 2002, vol: 4, page: 140, stat: Journal Article,

Cost-effectiveness of ancrod treatment of acute ischaemic stroke: results from the Stroke Treatment with Ancrod Trial (STAT)
Samsa, Gregory P; Matchar, David B; Williams, G Rhys; Levy, David E
2002 Feb;8(1):61-70, Journal of evaluation in clinical practice
— id: 93476, year: 2002, vol: 8, page: 61, stat: Journal Article,

Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes
Stockinger, Silvia; Materna, Tilo; Stoiber, Dagmar; Bayr, Lourdes; Steinborn, Ralf; Kolbe, Thomas; Unger, Hermann; Chakraborty, Trinad; Levy, David E; Muller, Mathias; Decker, Thomas
2002 Dec 1;169(11):6522-6529, Journal of immunology
— id: 93474, year: 2002, vol: 169, page: 6522, stat: Journal Article,

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
Zamo, Alberto; Chiarle, Roberto; Piva, Roberto; Howes, Jennifer; Fan, Yan; Chilosi, Marco; Levy, David E; Inghirami, Giorgio
2002 Feb 7;21(7):1038-1047, Oncogene
— id: 27551, year: 2002, vol: 21, page: 1038, stat: Journal Article,

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation
Zhu, Fan Xiu; King, Sonya M; Smith, Eric J; Levy, David E; Yuan, Yan
2002 Apr 16;99(8):5573-5578, Proceedings of the National Academy of Sciences of the United States of America
— id: 93475, year: 2002, vol: 99, page: 5573, stat: Journal Article,

Cooperation between STAT3 and c-jun suppresses Fas transcription
Ivanov, V N; Bhoumik, A; Krasilnikov, M; Raz, R; Owen-Schaub, L B; Levy, D; Horvath, C M; Ronai, Z
2001 Mar;7(3):517-528, Molecular cell
— id: 106997, year: 2001, vol: 7, page: 517, stat: Journal Article,

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
Kovarik, P; Mangold, M; Ramsauer, K; Heidari, H; Steinborn, R; Zotter, A; Levy, D E; Muller, M; Decker, T
2001 Jan 15;20(1-2):91-100, EMBO journal
— id: 138937, year: 2001, vol: 20, page: 91, stat: Journal Article,

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Levy DE; Garcia-Sastre A
2001 Jun;12(2-3):143-156, Cytokine & growth factor reviews
— id: 20700, year: 2001, vol: 12, page: 143, stat: Journal Article,

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
Polyak, S J; Khabar, K S; Paschal, D M; Ezelle, H J; Duverlie, G; Barber, G N; Levy, D E; Mukaida, N; Gretch, D R
2001 Jul;75(13):6095-6106, Journal of virology
— id: 138938, year: 2001, vol: 75, page: 6095, stat: Journal Article,

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
Sahni M; Raz R; Coffin JD; Levy D; Basilico C
2001 Jun;128(11):2119-2129, Development
— id: 26721, year: 2001, vol: 128, page: 2119, stat: Journal Article,

IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein
Smith EJ; Marie I; Prakash A; Garcia-Sastre A; Levy DE
2001 Mar 23;276(12):8951-8957, Journal of biological chemistry
— id: 21260, year: 2001, vol: 276, page: 8951, stat: Journal Article,

Type I IFN modulates innate and specific antiviral immunity
Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE
2000 Apr 15;164(8):4220-4228, Journal of immunology
— id: 11766, year: 2000, vol: 164, page: 4220, stat: Journal Article,

Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages
Goodman AR; Levy DE; Reis LF; Vilcek J
2000 Mar;67(3):387-395, Journal of leukocyte biology
— id: 11789, year: 2000, vol: 67, page: 387, stat: Journal Article,

Distinct requirements for IFNs and STAT1 in NK cell function
Lee CK; Rao DT; Gertner R; Gimeno R; Frey AB; Levy DE
2000 Oct 1;165(7):3571-3577, Journal of immunology
— id: 20292, year: 2000, vol: 165, page: 3571, stat: Journal Article,

STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma
Lee CK; Smith E; Gimeno R; Gertner R; Levy DE
2000 Feb 1;164(3):1286-1292, Journal of immunology
— id: 8573, year: 2000, vol: 164, page: 1286, stat: Journal Article,

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
Levy DE; Gilliland DG
2000 May 15;19(21):2505-2510, Oncogene
— id: 11657, year: 2000, vol: 19, page: 2505, stat: Journal Article,

Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain
Marie I; Smith E; Prakash A; Levy DE
2000 Dec;20(23):8803-8814, Molecular & cellular biology
— id: 39519, year: 2000, vol: 20, page: 8803, stat: Journal Article,

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
Schwaller J; Parganas E; Wang D; Cain D; Aster JC; Williams IR; Lee CK; Gerthner R; Kitamura T; Frantsve J; Anastasiadou E; Loh ML; Levy DE; Ihle JN; Gilliland DG
2000 Sep;6(3):693-704, Molecular cell
— id: 18491, year: 2000, vol: 6, page: 693, stat: Journal Article,

Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression
Weiden M; Tanaka N; Qiao Y; Zhao BY; Honda Y; Nakata K; Canova A; Levy DE; Rom WN; Pine R
2000 Aug 15;165(4):2028-2039, Journal of immunology
— id: 11568, year: 2000, vol: 165, page: 2028, stat: Journal Article,

Mechanism of STAT3 activation by insulin-like growth factor I receptor
Zong, C S; Chan, J; Levy, D E; Horvath, C; Sadowski, H B; Wang, L H
2000 May 19;275(20):15099-15105, Journal of biological chemistry
— id: 138936, year: 2000, vol: 275, page: 15099, stat: Journal Article,

Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes
Lee CK; Gimeno R; Levy DE
1999 Nov 15;190(10):1451-1464, Journal of experimental medicine
— id: 6240, year: 1999, vol: 190, page: 1451, stat: Journal Article,

Physiological significance of STAT proteins: investigations through gene disruption in vivo
Levy DE
1999 Sep;55(12):1559-1567, Cellular & molecular life sciences: CMLS
— id: 11944, year: 1999, vol: 55, page: 1559, stat: Journal Article,

The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3
Nadeau OW; Domanski P; Usacheva A; Uddin S; Platanias LC; Pitha P; Raz R; Levy D; Majchrzak B; Fish E; Colamonici OR
1999 Feb 12;274(7):4045-4052, Journal of biological chemistry
— id: 7991, year: 1999, vol: 274, page: 4045, stat: Journal Article,

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
Paulson M; Pisharody S; Pan L; Guadagno S; Mui AL; Levy DE
1999 Sep 3;274(36):25343-25349, Journal of biological chemistry
— id: 8480, year: 1999, vol: 274, page: 25343, stat: Journal Article,

Essential role of STAT3 for embryonic stem cell pluripotency
Raz R; Lee CK; Cannizzaro LA; d'Eustachio P; Levy DE
1999 Mar 16;96(6):2846-2851, Proceedings of the National Academy of Sciences of the United States of America
— id: 8219, year: 1999, vol: 96, page: 2846, stat: Journal Article,

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
Sahni M; Ambrosetti DC; Mansukhani A; Gertner R; Levy D; Basilico C
1999 Jun 1;13(11):1361-1366, Genes & development
— id: 12005, year: 1999, vol: 13, page: 1361, stat: Journal Article,

Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo
Fernandez-Sesma, A; Peluso, R W; Bai, X; Schulman, J L; Levy, D E; Moran, T M
1998 Feb 15;160(4):1841-1849, Journal of immunology
— id: 138966, year: 1998, vol: 160, page: 1841, stat: Journal Article,

The role of interferon in influenza virus tissue tropism
Garcia-Sastre A; Durbin RK; Zheng H; Palese P; Gertner R; Levy DE; Durbin JE
1998 Nov;72(11):8550-8558, Journal of virology
— id: 7576, year: 1998, vol: 72, page: 8550, stat: Journal Article,

Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
Garcia-Sastre, A; Egorov, A; Matassov, D; Brandt, S; Levy, D E; Durbin, J E; Palese, P; Muster, T
1998 Dec 20;252(2):324-330, Virology
— id: 138967, year: 1998, vol: 252, page: 324, stat: Journal Article,

Analysis of interferon-regulated proteins binding the interferon-alpha-stimulated response element
Levy DE
1998 Jul;15(3):167-174, Methods
— id: 7387, year: 1998, vol: 15, page: 167, stat: Journal Article,

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
Marie I; Durbin JE; Levy DE
1998 Nov 16;17(22):6660-6669, EMBO journal
— id: 7964, year: 1998, vol: 17, page: 6660, stat: Journal Article,

Essential role of STAT3 for embryonic stem cell growth
Raz, R; D'Eustachio, P; Kennizzaro, L; Levy, DE
1998 SEP ;9(3):328-328, European cytokine network
— id: 53660, year: 1998, vol: 9, page: 328, stat: Journal Article,

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation
Zheng P; Guo Y; Niu Q; Levy DE; Dyck JA; Lu S; Sheiman LA; Liu Y
1998 Nov 26;396(6709):373-376, Nature
— id: 7473, year: 1998, vol: 396, page: 373, stat: Journal Article,

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA
Bluyssen HA; Levy DE
1997 Feb 14;272(7):4600-4605, Journal of biological chemistry
— id: 12382, year: 1997, vol: 272, page: 4600, stat: Journal Article,

Regulation of interferon-alpha responsiveness by the duration of Janus kinase activity
Lee CK; Bluyssen HA; Levy DE
1997 Aug 29;272(35):21872-21877, Journal of biological chemistry
— id: 7193, year: 1997, vol: 272, page: 21872, stat: Journal Article,

The house that Jak/Stat built
Levy DE
1997 Mar;8(1):81-90, Cytokine & growth factor reviews
— id: 7197, year: 1997, vol: 8, page: 81, stat: Journal Article,

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons
Matikainen, S; Ronni, T; Lehtonen, A; Sareneva, T; Melen, K; Nordling, S; Levy, D E; Julkunen, I
1997 Jun;8(6):687-698, Cell growth & differentiation
— id: 138965, year: 1997, vol: 8, page: 687, stat: Journal Article,

ISGF3 gamma p48, a specificity switch for interferon activated transcription factors
Bluyssen AR; Durbin JE; Levy DE
1996 Jun;7(1):11-17, Cytokine & growth factor reviews
— id: 12594, year: 1996, vol: 7, page: 11, stat: Journal Article,

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
Durbin JE; Hackenmiller R; Simon MC; Levy DE
1996 Feb 9;84(3):443-450, Cell
— id: 6903, year: 1996, vol: 84, page: 443, stat: Journal Article,

Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
Leaman, D W; Pisharody, S; Flickinger, T W; Commane, M A; Schlessinger, J; Kerr, I M; Levy, D E; Stark, G R
1996 Jan;16(1):369-375, Molecular & cellular biology
— id: 138964, year: 1996, vol: 16, page: 369, stat: Journal Article,

Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells
Levy, J B; Schindler, C; Raz, R; Levy, D E; Baron, R; Horowitz, M C
1996 Apr;137(4):1159-1165, Endocrinology
— id: 106998, year: 1996, vol: 137, page: 1159, stat: Journal Article,

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses
Bluyssen HA; Muzaffar R; Vlieststra RJ; van der Made AC; Leung S; Stark GR; Kerr IM; Trapman J; Levy DE
1995 Jun 6;92(12):5645-5649, Proceedings of the National Academy of Sciences of the United States of America
— id: 12764, year: 1995, vol: 92, page: 5645, stat: Journal Article,

1995 JAN 5 ;336(3):30-30, Journal of cellular biochemistry
— id: 87348, year: 1995, vol: 336, page: 30, stat: Journal Article,

Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone
Campbell, G S; Meyer, D J; Raz, R; Levy, D E; Schwartz, J; Carter-Su, C
1995 Feb 24;270(8):3974-3979, Journal of biological chemistry
— id: 106999, year: 1995, vol: 270, page: 3974, stat: Journal Article,

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity
Gouilleux, F; Pallard, C; Dusanter-Fourt, I; Wakao, H; Haldosen, L A; Norstedt, G; Levy, D; Groner, B
1995 May 1;14(9):2005-2013, EMBO journal
— id: 138960, year: 1995, vol: 14, page: 2005, stat: Journal Article,

Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6
Henttinen, T; Levy, D E; Silvennoinen, O; Hurme, M
1995 Nov 15;155(10):4582-4587, Journal of immunology
— id: 138958, year: 1995, vol: 155, page: 4582, stat: Journal Article,

1995 JUN ;6(3):181-189, Seminars in virology
— id: 87242, year: 1995, vol: 6, page: 181, stat: Journal Article,

Thrombopoietin activates a STAT5-like factor in hematopoietic cells
Pallard, C; Gouilleux, F; Benit, L; Cocault, L; Souyri, M; Levy, D; Groner, B; Gisselbrecht, S; Dusanter-Fourt, I
1995 Jun 15;14(12):2847-2856, EMBO journal
— id: 138961, year: 1995, vol: 14, page: 2847, stat: Journal Article,

Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness
Raz R; Cheung K; Ling L; Levy DE
1995 Mar;21(2):139-145, Somatic cell & molecular genetics
— id: 12801, year: 1995, vol: 21, page: 139, stat: Journal Article,

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family
Bovolenta, C; Driggers, P H; Marks, M S; Medin, J A; Politis, A D; Vogel, S N; Levy, D E; Sakaguchi, K; Appella, E; Coligan, J E
1994 May 24;91(11):5046-5050, Proceedings of the National Academy of Sciences of the United States of America
— id: 138971, year: 1994, vol: 91, page: 5046, stat: Journal Article,

Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines
Lamb, P; Kessler, L V; Suto, C; Levy, D E; Seidel, H M; Stein, R B; Rosen, J
1994 Apr 15;83(8):2063-2071, Blood
— id: 138963, year: 1994, vol: 83, page: 2063, stat: Journal Article,

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
Raz R; Durbin JE; Levy DE
1994 Sep 30;269(39):24391-24395, Journal of biological chemistry
— id: 12890, year: 1994, vol: 269, page: 24391, stat: Journal Article,

Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors
Rothman P; Kreider B; Azam M; Levy D; Wegenka U; Eilers A; Decker T; Horn F; Kashleva H; Ihle J; et al.
1994 Sep;1(6):457-468, Immunity
— id: 18492, year: 1994, vol: 1, page: 457, stat: Journal Article,

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene
Seegert, D; Strehlow, I; Klose, B; Levy, D E; Schindler, C; Decker, T
1994 Mar 18;269(11):8590-8595, Journal of biological chemistry
— id: 138962, year: 1994, vol: 269, page: 8590, stat: Journal Article,

The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors
Parrington, J; Rogers, N C; Gewert, D R; Pine, R; Veals, S A; Levy, D E; Stark, G R; Kerr, I M
1993 Jun 15;214(3):617-626, European journal of biochemistry
— id: 138959, year: 1993, vol: 214, page: 617, stat: Journal Article,

Interferon-induced nuclear signalling by Jak protein tyrosine kinases
Silvennoinen O; Ihle JN; Schlessinger J; Levy DE
1993 Dec 9;366(6455):583-585, Nature
— id: 18493, year: 1993, vol: 366, page: 583, stat: Journal Article,

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation [see comments]
Silvennoinen O; Schindler C; Schlessinger J; Levy DE
1993 Sep 24;261(5129):1736-1739, Science
— id: 13070, year: 1993, vol: 261, page: 1736, stat: Journal Article,

Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity
Veals SA; Santa Maria T; Levy DE
1993 Jan;13(1):196-206, Molecular & cellular biology
— id: 13309, year: 1993, vol: 13, page: 196, stat: Journal Article,

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins
Veals SA; Schindler C; Leonard D; Fu XY; Aebersold R; Darnell JE Jr; Levy DE
1992 Aug;12(8):3315-3324, Molecular & cellular biology
— id: 13485, year: 1992, vol: 12, page: 3315, stat: Journal Article,

Protein kinase activity required for an early step in interferon-alpha signaling
Kessler, D S; Levy, D E
1991 Dec 5;266(34):23471-23476, Journal of biological chemistry
— id: 138968, year: 1991, vol: 266, page: 23471, stat: Journal Article,

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains
Fu XY; Kessler DS; Veals SA; Levy DE; Darnell JE Jr
1990 Nov;87(21):8555-8559, Proceedings of the National Academy of Sciences of the United States of America
— id: 63335, year: 1990, vol: 87, page: 8555, stat: Journal Article,

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator
Kessler, D S; Veals, S A; Fu, X Y; Levy, D E
1990 Oct;4(10):1753-1765, Genes & development
— id: 138969, year: 1990, vol: 4, page: 1753, stat: Journal Article,

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3
Levy, D E; Lew, D J; Decker, T; Kessler, D S; Darnell, J E Jr
1990 Apr;9(4):1105-1111, EMBO journal
— id: 138946, year: 1990, vol: 9, page: 1105, stat: Journal Article,

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either
Pine, R; Decker, T; Kessler, D S; Levy, D E; Darnell, J E Jr
1990 Jun;10(6):2448-2457, Molecular & cellular biology
— id: 138947, year: 1990, vol: 10, page: 2448, stat: Journal Article,

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein
Decker, T; Lew, D J; Cheng, Y S; Levy, D E; Darnell, J E Jr
1989 Jul;8(7):2009-2014, EMBO journal
— id: 138950, year: 1989, vol: 8, page: 2009, stat: Journal Article,

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro
Levy DE; Kessler DS; Pine R; Darnell JE Jr
1989 Sep;3(9):1362-1371, Genes & development
— id: 10512, year: 1989, vol: 3, page: 1362, stat: Journal Article,

Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation
Raj, N B; Engelhardt, J; Au, W C; Levy, D E; Pitha, P M
1989 Oct 5;264(28):16658-16666, Journal of biological chemistry
— id: 138951, year: 1989, vol: 264, page: 16658, stat: Journal Article,

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes
Kessler, D S; Levy, D E; Darnell, J E Jr
1988 Nov;85(22):8521-8525, Proceedings of the National Academy of Sciences of the United States of America
— id: 138949, year: 1988, vol: 85, page: 8521, stat: Journal Article,

Cells resistant to interferon are defective in activation of a promoter-binding factor
Kessler, D S; Pine, R; Pfeffer, L M; Levy, D E; Darnell, J E Jr
1988 Dec 1;7(12):3779-3783, EMBO journal
— id: 138952, year: 1988, vol: 7, page: 3779, stat: Journal Article,

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control
Levy, D E; Kessler, D S; Pine, R; Reich, N; Darnell, J E Jr
1988 Apr;2(4):383-393, Genes & development
— id: 138955, year: 1988, vol: 2, page: 383, stat: Journal Article,

Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it
Levy, D; Reich, N; Kessler, D; Pine, R; Darnell, J E Jr
1988 ;53 Pt 2:799-802, Cold Spring Harbor symposia on quantitative biology
— id: 138954, year: 1988, vol: 53 Pt 2, page: 799, stat: Journal Article,

Transcriptional stimulation by CaPO4-DNA precipitates
Pine, R; Levy, D E; Reich, N; Darnell, J E Jr
1988 Feb 25;16(4):1371-1378, Nucleic acids research
— id: 138953, year: 1988, vol: 16, page: 1371, stat: Journal Article,

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products
Reich, N; Pine, R; Levy, D; Darnell, J E Jr
1988 Jan;62(1):114-119, Journal of virology
— id: 138948, year: 1988, vol: 62, page: 114, stat: Journal Article,

Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients
Levy DE; Sidtis JJ; Rottenberg DA; Jarden JO; Strother SC; Dhawan V; Ginos JZ; Tramo MJ; Evans AC; Plum F
1987 Dec;22(6):673-682, Annals of neurology
— id: 60874, year: 1987, vol: 22, page: 673, stat: Journal Article,

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element
Reich, N; Evans, B; Levy, D; Fahey, D; Knight, E Jr; Darnell, J E Jr
1987 Sep;84(18):6394-6398, Proceedings of the National Academy of Sciences of the United States of America
— id: 138957, year: 1987, vol: 84, page: 6394, stat: Journal Article,

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region
Levy, D; Larner, A; Chaudhuri, A; Babiss, L E; Darnell, J E Jr
1986 Dec;83(23):8929-8933, Proceedings of the National Academy of Sciences of the United States of America
— id: 138956, year: 1986, vol: 83, page: 8929, stat: Journal Article,

Outcome from severe neurological illness; should it influence medical decisions?
Plum, Fred; Levy, David E
1979 ;No. 69:267-277, CIBA Foundation symposium
— id: 93478, year: 1979, vol: No. 69, page: 267, stat: Journal Article,