David E Levy

Biosketch / Results /

David E Levy, Ph.D.

Dr. Louis A. Schneider Professor of Molecular Pathology; Professor; Assoc Director Perlmutter Cancer Center; Dir Molecular Onc & Immunology Grad/PstDoc Trng Pg; Assoc Dean Collaborative Science
Departments of Pathology (Pathology) and Microbiology (Microbiology )

Contact Info

Address
550 First Avenue
Dept. of Pathology Floor 5 Room 538/548
Medical Science Building
New York, NY 10016

212-263-8192, 212-263-1494
509-757-3029, 212-263-8211
David.Levy@nyumc.org


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Education

— Dr. Levy was awarded a NIH Postdoctoral Fellowship for the period 1984-87 which was spent at the Lab of Molecular Cell Biology at the Rockefeller University, PostDoctoral Training
1985 — Molecular Biology from the California Institute of Technology, Pasadena, CA, Graduate Education

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Research Summary

The phenotype of a mammalian cell is modulated in response to physiological signals partly through the differential activation of specific gene expression. One way cells detect environmental cues and cell-cell interactions is through binding of extracellular ligands to cell-surface receptors. Responses to cell surface binding of cytokines, a diverse family of secreted polypeptides regulating cellular growth and differentiation, lead to profound alterations in the metabolic profile of susceptible cells. We focus on the mechanisms of action of growth inhibitory interferons, of growth-promoting factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), and of T-cell activation factors, such as interleukin-2 (IL-2).

We found that much of the immediate response to IFNs is mediated by transcriptional activation of a discrete set of IFN-stimulated genes through the action of a novel transcription factor that binds an IFN-sensitive enhancer element only following IFN treatment. Purifying and cloning this transcription factor showed that it consists of several different polypeptides that are regulated by tyrosine phosphorylation, causing this multimeric factor to assemble and to translocate to the nucleus. We study the mechanisms of subunit assembly, the kinases responsible for regulated tyrosine phosphorylation, and signal coupling between IFN receptors and the kinase/transcription factor complex.

Additionally, we are investigating the normal physiological relevance of these signaling pathways in vivo with gene targeting. We disrupted the genes for individual signaling proteins in embryonic stem cells through homologous recombination. We used these altered stem cells to populate normal mouse blastocysts to produce laboratory mice strains carrying the specific mutations. Now we are studying the phenotypes of the mutant mice to determine the role for cytokine signaling pathways in development, immune responses, and defense against pathogens. This has enabled us to establish several disease models that can now be studied at the molecular level.

One of the signaling proteins we study is Stat3, a transcription factor responsible for gene expression in response to many cytokines, especially those of the IL6 family. We have disrupted the gene for Stat3 in mice, but because this disruption led to an embryonic lethal phenotype, we have also constructed a conditional mutant version of Stat3 by using the Cre-loxP system. We can cause the Stat3 disruption inducibly in specific tissues or cell types and therefore study the phenotype resulting from loss of Stat3 function, for instance in B lymphocytes or liver. These studies will help define the molecular basis of B cell proliferation and maturation and of the acute phase response to pathogens. In combination with genetic models of IFN deficiency, we are examining aspects of the innate immune response.

One of the components of the innate immune response is the ability to respond to virus infection by production of IFN. We have defined an essential transcription factor for induction of members of the IFN-alpha gene family. This protein, IRF7, becomes phosphorylated specifically in virus-infected cells, causing it to translocate to the nucleus, bind DNA, and activate transcription. We have defined the structure/function relationships for its different activities and are pursuing the role for this protein in responses to a variety of infectious agents. Knowledge from these projects is being used to develop novel antiviral agents.

Research Interests

Cytokine Signaling Signal Transduction and Gene Expression

Research Keywords

cytokines, interferons, gene expression, gene targeting, gene transcription, growth factors, infection and immunity

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

The human RVB complex is required for efficient transcription of type I interferon-stimulated genes
Gnatovskiy, Leonid; Mita, Paolo; Levy, David E
2013 Oct;33(19):3817-3825, Molecular & cellular biology
— id: 575612, year: 2013, vol: 33, page: 3817, stat: Journal Article,

Mitochondrial STAT3 supports K-Ras driven myeloid leukaemia in vivo
Gough, Daniel J.; Levy, David E.
2013 SEP;63(3):266-267, Cytokine
— id: 557542, year: 2013, vol: 63, page: 266, stat: Journal Article,

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
Gough, Daniel J; Koetz, Lisa; Levy, David E
2013 ;8(11):e83395-e83395 e83395, PLoS ONE
— id: 681112, year: 2013, vol: 8, page: e83395, stat: Journal Article,

STAT1-deficient mice spontaneously develop estrogen receptor alpha-positive luminal mammary carcinomas
Chan, Szeman Ruby; Vermi, William; Luo, Jingqin; Lucini, Laura; Rickert, Charles; Fowler, Amy M.; Lonardi, Silvia; Arthur, Cora; Young, Larry J. T.; Levy, David E.; Welch, Michael J.; Cardiff, Robert D.; Schreiber, Robert D.
2012 ;14(1):-, Breast cancer research
— id: 178169, year: 2012, vol: 14, page: , stat: Journal Article,

Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN-gamma-Induced Gene Expression
Farlik, Matthias; Rapp, Birgit; Marie, Isabelle; Levy, David E; Jamieson, Amanda M; Decker, Thomas
2012 Mar;32(6):1032-1043, Molecular & cellular biology
— id: 160243, year: 2012, vol: 32, page: 1032, stat: Journal Article,

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling
Gough, Daniel J; Messina, Nicole L; Clarke, Christopher J P; Johnstone, Ricky W; Levy, David E
2012 Feb;36(2):166-174, Immunity
— id: 158280, year: 2012, vol: 36, page: 166, stat: Journal Article,

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function
Lee, J E; Yang, Y -M; Liang, F -X; Gough, D J; Levy, D E; Sehgal, P B
2012 March 2012;302(5):804-820, American journal of physiology. Cell physiology
— id: 161210, year: 2012, vol: 302, page: 804, stat: Journal Article,

STATus Report on Tetramers
Levy, David E; Marie, Isabelle J
2012 Apr;36(4):553-555, Immunity
— id: 165619, year: 2012, vol: 36, page: 553, stat: Journal Article,

Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface
Nancy, Patrice; Tagliani, Elisa; Tay, Chin-Siean; Asp, Patrik; Levy, David E; Erlebacher, Adrian
2012 Jun;336(6086):1317-1321, Science
— id: 169515, year: 2012, vol: 336, page: 1317, stat: Journal Article,

Comparative evolutionary genomics of the STAT family of transcription factors
Wang, Yaming; Levy, David E
2012 Jan;1(1):23-33, JAK-STAT
— id: 1051522, year: 2012, vol: 1, page: 23, stat: Journal Article,

A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh
Wu, F; Chen, Y; Liu, M L; Parvez, F; Slavkovich, V; Eunus, M; Ahmed, A; Segers, S; Argos, M; Islam, T; Rakibuz-Zaman, M; Hasan, R; Sarwar, G; Levy, D; Graziano, J H; Ahsan, H
2012 15 Jun 2012;175:S138-S138, American journal of epidemiology
— id: 174160, year: 2012, vol: 175, page: S138, stat: Journal Article,

Association between arsenic exposure from drinking water and electrocardiographic abnormality of heart rate-corrected QT-interval prolongation: Results from the health effects of arsenic longitudinal study
Wu, F; Chen, Y; Parvez, F; Ahmed, A; Eunus, M; McClintock, T R; Patwary, T I; Islam, T; Ghosal, A K; Islam, S; Hasan, R; Levy, D; Sarwar, G; Slavkovich, V; Van, Geen A; Graziano, J H; Ahsan, H
2012 15 Jun 2012;175:S8-S8, American journal of epidemiology
— id: 174161, year: 2012, vol: 175, page: S8, stat: Journal Article,

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
Zhang, Liang; Das, Priyabrata; Schmolke, Mirco; Manicassamy, Balaji; Wang, Yaming; Deng, Xiaoyi; Cai, Ling; Tu, Benjamin P; Forst, Christian V; Roth, Michael G; Levy, David E; Garcia-Sastre, Adolfo; de Brabander, Jef; Phillips, Margaret A; Fontoura, Beatriz M A
2012 Feb;196(3):315-326, Journal of cell biology
— id: 158676, year: 2012, vol: 196, page: 315, stat: Journal Article,

TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10-Mediated Suppression of Antitumor Immunity
Bogunovic, Dusan; Manches, Olivier; Godefroy, Emmanuelle; Yewdall, Alice; Gallois, Anne; Salazar, Andres M; Marie, Isabelle; Levy, David E; Bhardwaj, Nina
2011 Aug 15;71(16):5467-5476, Cancer research
— id: 136637, year: 2011, vol: 71, page: 5467, stat: Journal Article,

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
Corcoran, Ryan B; Contino, Gianmarco; Deshpande, Vikram; Tzatsos, Alexandros; Conrad, Claudius; Benes, Cyril H; Levy, David E; Settleman, Jeffrey; Engelman, Jeffrey A; Bardeesy, Nabeel
2011 Jul 15;71(14):5020-5029, Cancer research
— id: 135540, year: 2011, vol: 71, page: 5020, stat: Journal Article,

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis
Kaplan, Mark H; Glosson, Nicole L; Stritesky, Gretta L; Yeh, Norman; Kinzfogl, John; Rohrabaugh, Sara L; Goswami, Ritobrata; Pham, Duy; Levy, David E; Brutkiewicz, Randy R; Blum, Janice S; Cooper, Scott; Hangoc, Giao; Broxmeyer, Hal E
2011 Jun 9;117(23):6198-6201, Blood
— id: 141123, year: 2011, vol: 117, page: 6198, stat: Journal Article,

Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of foxp3 expression and treg function
Lal, G; Yin, N; Xu, J; Lin, M; Schroppel, S; Ding, Y; Marie, I; Levy, D E; Bromberg, J S
2011 Feb;11(2):203-214, American journal of transplantation
— id: 122535, year: 2011, vol: 11, page: 203, stat: Journal Article,

Induction and function of type I and III interferon in response to viral infection
Levy, David E; Marie, Isabelle J; Durbin, Joan E
2011 Dec;1(6):476-486, Current opinion in virology
— id: 166500, year: 2011, vol: 1, page: 476, stat: Journal Article,

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype
O'Brien, Meagan; Manches, Olivier; Sabado, Rachel Lubong; Baranda, Sonia Jimenez; Wang, Yaming; Marie, Isabelle; Rolnitzky, Linda; Markowitz, Martin; Margolis, David M; Levy, David; Bhardwaj, Nina
2011 Mar 1;121(3):1088-1101, Journal of clinical investigation
— id: 130297, year: 2011, vol: 121, page: 1088, stat: Journal Article,

The transcription factor STAT3 is required for T helper 2 cell development
Stritesky, Gretta L; Muthukrishnan, Rajarajeswari; Sehra, Sarita; Goswami, Ritobrata; Pham, Duy; Travers, Jared; Nguyen, Evelyn T; Levy, David E; Kaplan, Mark H
2011 Jan 28;34(1):39-49, Immunity
— id: 132218, year: 2011, vol: 34, page: 39, stat: Journal Article,

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
Wang, Ding; Zavadil, Jiri; Martin, Leenus; Parisi, Fabio; Friedman, Eugene; Levy, David; Harding, Heather; Ron, David; Gardner, Lawrence B
2011 Sep;31(17):3670-3680, Molecular & cellular biology
— id: 136513, year: 2011, vol: 31, page: 3670, stat: Journal Article,

STAT3 negatively regulates type I IFN-mediated antiviral response
Wang, Wei-Bei; Levy, David E; Lee, Chien-Kuo
2011 Sep 1;187(5):2578-2585, Journal of immunology
— id: 138428, year: 2011, vol: 187, page: 2578, stat: Journal Article,

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
Demaria, Marco; Giorgi, Carlotta; Lebiedzinska, Magdalena; Esposito, Giovanna; D'Angeli, Luca; Bartoli, Antonietta; Gough, Daniel J; Turkson, James; Levy, David E; Watson, Christine J; Wieckowski, Mariusz R; Provero, Paolo; Pinton, Paolo; Poli, Valeria
2010 Nov;2(11):823-842, Aging
— id: 134403, year: 2010, vol: 2, page: 823, stat: Journal Article,

Functional crosstalk between type I and II interferon through the regulated expression of STAT1
Gough, Daniel J; Messina, Nicole L; Hii, Linda; Gould, Jodee A; Sabapathy, Kanaga; Robertson, Ashley P S; Trapani, Joseph A; Levy, David E; Hertzog, Paul J; Clarke, Christopher J P; Johnstone, Ricky W
2010 ;8(4):e1000361-e1000361, PLoS biology
— id: 138944, year: 2010, vol: 8, page: e1000361, stat: Journal Article,

Non-canonical functions of STAT3 in growth and tumorigenesis
Gough, Daniel; Jones, Courtney; Wang, Yaming; Marie, Isabelle; Levy, David E.
2010 OCT-NOV ;52(1-2):36-36, Cytokine
— id: 113933, year: 2010, vol: 52, page: 36, stat: Journal Article,

NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip?
Levy, David E
2010 Jul 23;33(1):1-2, Immunity
— id: 111362, year: 2010, vol: 33, page: 1, stat: Journal Article,

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Manel, Nicolas; Hogstad, Brandon; Wang, Yaming; Levy, David E; Unutmaz, Derya; Littman, Dan R
2010 Sep 9;467(7312):214-217, Nature
— id: 112431, year: 2010, vol: 467, page: 214, stat: Journal Article,

STAT3 negatively regulates type I IFN-mediated signaling and functions
Wang, Wei-Bei; Den, Hao-Kang; Levy, David E.; Lee, Chien-Kuo
2010 OCT-NOV ;52(1-2):65-65, Cytokine
— id: 113935, year: 2010, vol: 52, page: 65, stat: Journal Article,

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation
Gough, Daniel J; Corlett, Alicia; Schlessinger, Karni; Wegrzyn, Joanna; Larner, Andrew C; Levy, David E
2009 Jun 26;324(5935):1713-1716, Science
— id: 100615, year: 2009, vol: 324, page: 1713, stat: Journal Article,

Activation of Stat3 in renal tumors
Guo, Charles; Yang, Guanyu; Khun, Kyle; Kong, Xiantian; Levy, David; Lee, Peng; Melamed, Jonathan
2009 ;1(3):283-290, American journal of translational research
— id: 105529, year: 2009, vol: 1, page: 283, stat: Journal Article,

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
Kwon, Hyokjoon; Thierry-Mieg, Danielle; Thierry-Mieg, Jean; Kim, Hyoung-Pyo; Oh, Jangsuk; Tunyaplin, Chainarong; Carotta, Sebastian; Donovan, Colleen E; Goldman, Matthew L; Tailor, Prafullakumar; Ozato, Keiko; Levy, David E; Nutt, Stephen L; Calame, Kathryn; Leonard, Warren J
2009 Dec 18;31(6):941-952, Immunity
— id: 138943, year: 2009, vol: 31, page: 941, stat: Journal Article,

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
Lal, Girdhari; Zhang, Nan; van der Touw, William; Ding, Yaozhong; Ju, Wenjun; Bottinger, Erwin P; Reid, St Patrick; Levy, David E; Bromberg, Jonathan S
2009 Jan 1;182(1):259-273, Journal of immunology
— id: 93449, year: 2009, vol: 182, page: 259, stat: Journal Article,

Ancrod for acute ischemic stroke: a new dosing regimen derived from analysis of prior ancrod stroke studies
Levy, David E; Trammel, James; Wasiewski, Warren W
2009 Jan;18(1):23-27, Journal of stroke & cerebrovascular diseases
— id: 93448, year: 2009, vol: 18, page: 23, stat: Journal Article,

Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy
Lu, Ting-Chi; Wang, Zhao-Hui; Feng, Xiaobei; Chuang, Peter Y; Fang, Wei; Shen, Yuhong; Levy, David E; Xiong, Huabao; Chen, Nan; He, John Cijiang
2009 Jul;76(1):63-71, Kidney international
— id: 138970, year: 2009, vol: 76, page: 63, stat: Journal Article,

Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells
O'Malley, John T; Sehra, Sarita; Thieu, Vivian T; Yu, Qing; Chang, Hua-Chen; Stritesky, Gretta L; Nguyen, Evelyn T; Mathur, Anubhav N; Levy, David E; Kaplan, Mark H
2009 Aug;127(4):587-595, Immunology
— id: 132219, year: 2009, vol: 127, page: 587, stat: Journal Article,

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression
Ranger, Jill J; Levy, David E; Shahalizadeh, Solmaz; Hallett, Michael; Muller, William J
2009 Sep 1;69(17):6823-6830, Cancer research
— id: 138942, year: 2009, vol: 69, page: 6823, stat: Journal Article,

IL-21 mediates suppressive effects via its induction of IL-10
Spolski, Rosanne; Kim, Hyoung-Pyo; Zhu, Wei; Levy, David E; Leonard, Warren J
2009 Mar 1;182(5):2859-2867, Journal of immunology
— id: 93447, year: 2009, vol: 182, page: 2859, stat: Journal Article,

Analysis of chikungunya viral protein interactions with the interferon response pathway
Tangeman, M; Briese, T; Lipkin, WI; Levy, DE
2009 OCT-NOV ;48(1-2):60-60, Cytokine
— id: 105955, year: 2009, vol: 48, page: 60, stat: Journal Article,

c-Maf regulates IL-10 expression during Th17 polarization
Xu, Jiangnan; Yang, Yu; Qiu, Guixing; Lal, Girdhari; Wu, Zhihong; Levy, David E; Ochando, Jordi C; Bromberg, Jonathan S; Ding, Yaozhong
2009 May 15;182(10):6226-6236, Journal of immunology
— id: 138941, year: 2009, vol: 182, page: 6226, stat: Journal Article,

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
Bonni, Azad; Depinho, Ronald A; Levy, David E; You, Mingjian J; Bachoo, Robert M; Chan, Jennifer A; Puram, Sidharth V; Konopka, Genevieve; de la Iglesia, Nuria
2008 Feb 15;22(4):449-462, Genes & development
— id: 93452, year: 2008, vol: 22, page: 449, stat: Journal Article,

Nucleoporin levels regulate cell cycle progression and phase-specific gene expression
Chakraborty, Papia; Wang, Yaming; Wei, Jen-Hsuan; van Deursen, Jan; Yu, Hongtao; Malureanu, Liviu; Dasso, Mary; Forbes, Douglass J; Levy, David E; Seemann, Joachim; Fontoura, Beatriz M A
2008 Nov;15(5):657-667, Developmental cell
— id: 93450, year: 2008, vol: 15, page: 657, stat: Journal Article,

Vaccinia virus protein E3L inhibits type I interferon induction by the cytoplasmic signaling pathway
Friedman, E; Marie, IJ; Levy, DE
2008 SEP ;43(3):300-301, Cytokine
— id: 91472, year: 2008, vol: 43, page: 300, stat: Journal Article,

IFNgamma signaling-does it mean JAK-STAT?
Gough, Daniel J; Levy, David E; Johnstone, Ricky W; Clarke, Christopher J
2008 Oct-Dec;19(5-6):383-394, Cytokine & growth factor reviews
— id: 93451, year: 2008, vol: 19, page: 383, stat: Journal Article,

Monocytes in the urine of children with lupus: A potential marker of active nephritis
Kahn, PJ; Zhang, HZ; Levy, D; Imundo, L; Eichenfield, A; Winchestet, R
2008 ;58(9):S252-S252, Arthritis & rheumatism
— id: 90034, year: 2008, vol: 58, page: S252, stat: Journal Article,

Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3
Joo, Chul Hyun; Shin, Young C; Gack, Michaela; Wu, Liguo; Levy, David; Jung, Jae U
2007 Aug;81(15):8282-8292, Journal of virology
— id: 138972, year: 2007, vol: 81, page: 8282, stat: Journal Article,

STAT3 signaling and the hyper-IgE syndrome
Levy, David E; Loomis, Cynthia A
2007 Oct 18;357(16):1655-1658, New England journal of medicine
— id: 93454, year: 2007, vol: 357, page: 1655, stat: Journal Article,

The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses
MacDonald, Margaret R; Machlin, Erica S; Albin, Owen R; Levy, David E
2007 Dec;81(24):13509-13518, Journal of virology
— id: 93453, year: 2007, vol: 81, page: 13509, stat: Journal Article,

Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling
Mahajan, Muktar A; Murray, Audrey; Levy, David; Samuels, Herbert H
2007 Aug;21(8):1822-1834, Molecular endocrinology
— id: 73864, year: 2007, vol: 21, page: 1822, stat: Journal Article,

Stat3 and Stat4 direct development of IL-17-secreting Th cells
Mathur, Anubhav N; Chang, Hua-Chen; Zisoulis, Dimitrios G; Stritesky, Gretta L; Yu, Qing; O'Malley, John T; Kapur, Reuben; Levy, David E; Kansas, Geoffrey S; Kaplan, Mark H
2007 Apr 15;178(8):4901-4907, Journal of immunology
— id: 93456, year: 2007, vol: 178, page: 4901, stat: Journal Article,

Influenza virus targets the mRNA export machinery and the nuclear pore complex
Satterly, Neal; Tsai, Pei-Ling; van Deursen, Jan; Nussenzveig, Daniel R; Wang, Yaming; Faria, Paula A; Levay, Agata; Levy, David E; Fontoura, Beatriz M A
2007 Feb 6;104(6):1853-1858, Proceedings of the National Academy of Sciences of the United States of America
— id: 93457, year: 2007, vol: 104, page: 1853, stat: Journal Article,

JAK-STAT signaling: from interferons to cytokines
Schindler, Christian; Levy, David E; Decker, Thomas
2007 Jul 13;282(28):20059-20063, Journal of biological chemistry
— id: 93455, year: 2007, vol: 282, page: 20059, stat: Journal Article,

Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity
Tseng, J-C; Zheng, Y; Yee, H; Levy, D E; Meruelo, D
2007 Aug;14(15):1166-1174, Gene therapy
— id: 74661, year: 2007, vol: 14, page: 1166, stat: Journal Article,

Multiple signaling pathways are involved in IL-21-mediated proliferation
Zeng, R; Spolski, R; Casas, E; Zhu, W; Levy, DE; Leonard, WJ
2007 JUL ;39(1):48-48, Cytokine
— id: 87204, year: 2007, vol: 39, page: 48, stat: Journal Article,

The molecular basis of IL-21-mediated proliferation
Zeng, Rong; Spolski, Rosanne; Casas, Esther; Zhu, Wei; Levy, David E; Leonard, Warren J
2007 May 15;109(10):4135-4142, Blood
— id: 93458, year: 2007, vol: 109, page: 4135, stat: Journal Article,

IL-6 programs TH-17 cell differentiation by promoting the sequential engagement of the IL-21 and IL-23 pathways
Zhou, L; Ivanov, II; Spolski, R; Min, R; Shenderov, K; Egawa, T; Levy, DE; Leonard, WJ; Littman, DR
2007 JUL ;39(1):49-49, Cytokine
— id: 87205, year: 2007, vol: 39, page: 49, stat: Journal Article,

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Zhou, Liang; Ivanov, Ivaylo I; Spolski, Rosanne; Min, Roy; Shenderov, Kevin; Egawa, Takeshi; Levy, David E; Leonard, Warren J; Littman, Dan R
2007 Sep;8(9):967-974, Nature immunology
— id: 74681, year: 2007, vol: 8, page: 967, stat: Journal Article,

STAT3 positively regulates an early step in B-cell development
Chou, Wei-Chun; Levy, David E; Lee, Chien-Kuo
2006 Nov 1;108(9):3005-3011, Blood
— id: 93462, year: 2006, vol: 108, page: 3005, stat: Journal Article,

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions
Faria, Ana M C; Levay, Agata; Wang, Yaming; Kamphorst, Alice O; Rosa, Magda L P; Nussenzveig, Daniel R; Balkan, Wayne; Chook, Yuh Min; Levy, David E; Fontoura, Beatriz M A
2006 Mar;24(3):295-304, Immunity
— id: 93464, year: 2006, vol: 24, page: 295, stat: Journal Article,

Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
Huang, Bo; Pan, Ping-Ying; Li, Qingsheng; Sato, Alice I; Levy, David E; Bromberg, Jonathan; Divino, Celia M; Chen, Shu-Hsia
2006 Jan 15;66(2):1123-1131, Cancer research
— id: 93465, year: 2006, vol: 66, page: 1123, stat: Journal Article,

STAT1 acts as a tumor promoter for leukemia development
Kovacic, Boris; Stoiber, Dagmar; Moriggl, Richard; Weisz, Eva; Ott, Rene G; Kreibich, Rita; Levy, David E; Beug, Hartmut; Freissmuth, Michael; Sexl, Veronika
2006 Jul;10(1):77-87, Cancer cell
— id: 93461, year: 2006, vol: 10, page: 77, stat: Journal Article,

STAT3: a multifaceted oncogene
Levy, David E; Inghirami, Giorgio
2006 Jul 5;103(27):10151-10152, Proceedings of the National Academy of Sciences of the United States of America
— id: 67388, year: 2006, vol: 103, page: 10151, stat: Journal Article,

Gemcitabine (G) plamsa and intracellular pharmacokinetics in E6201: Greater metabolite levels using fixed dosing rate (FDR) delivery
Liebes, L; Levy, DE; Poplin, E; Mendoza, S; Fry, D; Buckley, M; Zoloratov, A; Benson, A; Hochster, H
2006 JUN 20 ;24(18):85S-85S, Journal of clinical oncology
— id: 69295, year: 2006, vol: 24, page: 85S, stat: Journal Article,

Regulation of IRF7 through cell type-specific protein stability
Prakash, Arun; Levy, David E
2006 Mar 31;342(1):50-56, Biochemical & biophysical research communications
— id: 63740, year: 2006, vol: 342, page: 50, stat: Journal Article,

Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling
Sun, Wei; Snyder, Marylynn; Levy, David E; Zhang, J Jillian
2006 Oct 30;580(25):5880-5884, FEBS letters
— id: 93459, year: 2006, vol: 580, page: 5880, stat: Journal Article,

C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation
Wang, Yaming; Levy, David E
2006 Jan 10;16(1):89-94, Current biology. CB
— id: 62749, year: 2006, vol: 16, page: 89, stat: Journal Article,

C. elegans STAT: evolution of a regulatory switch
Wang, Yaming; Levy, David E
2006 Aug;20(10):1641-1652, FASEB journal
— id: 68775, year: 2006, vol: 20, page: 1641, stat: Journal Article,

Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR
Wang, Yaming; Zhu, Wei; Levy, David E
2006 Aug;39(4):356-362, Methods
— id: 93460, year: 2006, vol: 39, page: 356, stat: Journal Article,

An IL-21 receptor tyrosine is critical for IL-21-induced proliferation and the activation of Stat1 and Stat3
Zeng, R; Spolski, R; Casas, E; Levy, DE; Leonard, WJ
2006 APR 1 ;176(4):S14-S14, Journal of immunology
— id: 68834, year: 2006, vol: 176, page: S14, stat: Journal Article,

IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain
Zhang, Ling; Badgwell, Donna B; Bevers, Jack J 3rd; Schlessinger, Karni; Murray, Peter J; Levy, David E; Watowich, Stephanie S
2006 Aug;288(1-2):179-189, Molecular & cellular biochemistry
— id: 93463, year: 2006, vol: 288, page: 179, stat: Journal Article,

Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7
Caillaud, Alexandre; Hovanessian, Ara G; Levy, David E; Marie, Isabelle J
2005 May 6;280(18):17671-17677, Journal of biological chemistry
— id: 93468, year: 2005, vol: 280, page: 17671, stat: Journal Article,

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells
Gysemans, Conny A; Ladriere, Laurence; Callewaert, Hanne; Rasschaert, Joanne; Flamez, Daisy; Levy, David E; Matthys, Patrick; Eizirik, Decio L; Mathieu, Chantal
2005 Aug;54(8):2396-2403, Diabetes
— id: 93466, year: 2005, vol: 54, page: 2396, stat: Journal Article,

New and old functions of STAT3: a pivotal target for individualized treatment of cancer
Inghirami, Giorgio; Chiarle, Roberto; Simmons, William J; Piva, Roberto; Schlessinger, Karni; Levy, David E
2005 Sep;4(9):1131-1133, Cell cycle
— id: 64467, year: 2005, vol: 4, page: 1131, stat: Journal Article,

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons
Li, Yongzhong; Batra, Sandeep; Sassano, Antonella; Majchrzak, Beata; Levy, David E; Gaestel, Matthias; Fish, Eleanor N; Davis, Roger J; Platanias, Leonidas C
2005 Mar 18;280(11):10001-10010, Journal of biological chemistry
— id: 93471, year: 2005, vol: 280, page: 10001, stat: Journal Article,

Cell signaling. Stat acetylation--a key facet of cytokine signaling?
O'Shea, John J; Kanno, Yuka; Chen, Xiaomin; Levy, David E
2005 Jan 14;307(5707):217-218, Science
— id: 93470, year: 2005, vol: 307, page: 217, stat: Journal Article,

Reduced STAT3 activity in mice mimics clinical disease syndromes
Shen, Yuhong; La Perle, Krista M D; Levy, David E; Darnell, James E Jr
2005 Apr 29;330(1):305-309, Biochemical & biophysical research communications
— id: 93467, year: 2005, vol: 330, page: 305, stat: Journal Article,

Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1
Shi, Shuangping; Blumenthal, Antje; Hickey, Christopher M; Gandotra, Sheetal; Levy, David; Ehrt, Sabine
2005 Sep 1;175(5):3318-3328, Journal of immunology
— id: 138940, year: 2005, vol: 175, page: 3318, stat: Journal Article,

Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages
Tanaka, Naohiko; Hoshino, Yoshihiko; Gold, Jeffrey; Hoshino, Satomi; Martiniuk, Frank; Kurata, Takeshi; Pine, Richard; Levy, David; Rom, William N; Weiden, Michael
2005 Oct;33(4):406-411, American journal of respiratory cell & molecular biology
— id: 58745, year: 2005, vol: 33, page: 406, stat: Journal Article,

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
Yang, Jinbo; Chatterjee-Kishore, Moitreyee; Staugaitis, Susan M; Nguyen, Hannah; Schlessinger, Karni; Levy, David E; Stark, George R
2005 Feb 1;65(3):939-947, Cancer research
— id: 93469, year: 2005, vol: 65, page: 939, stat: Journal Article,

Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent
Chesler, David A; Dodard, Cindy; Lee, Grace Y; Levy, David E; Reiss, Carol Shoshkes
2004 Feb;10(1):57-63, Journal of neurovirology
— id: 42151, year: 2004, vol: 10, page: 57, stat: Journal Article,

Role of interferons in an in vivo model of inhalational anthrax
Gold JA; Jones MB; Levy DE; Hoshino Y; Nolan A; Weiden MD
2004 ;169:A230-A230, American journal of respiratory & critical care medicine
— id: 101401, year: 2004, vol: 169, page: A230, stat: Journal Article,

Art and the brain: the influence of art on Roger Shepard's studies of mental rotation
Levy, Ellen K; Levy, David E; Goldberg, Michael E
2004 Mar;13(1):79-90, Journal of the history of the neurosciences
— id: 93472, year: 2004, vol: 13, page: 79, stat: Journal Article,

Role of p38alpha Map kinase in Type I interferon signaling
Li, Yongzhong; Sassano, Antonella; Majchrzak, Beata; Deb, Dilip K; Levy, David E; Gaestel, Matthias; Nebreda, Angel R; Fish, Eleanor N; Platanias, Leonidas C
2004 Jan 9;279(2):970-979, Journal of biological chemistry
— id: 42152, year: 2004, vol: 279, page: 970, stat: Journal Article,

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation
Shen, Yuhong; Schlessinger, Karni; Zhu, Xuejun; Meffre, Eric; Quimby, Fred; Levy, David E; Darnell, J E Jr
2004 Jan;24(1):407-419, Molecular & cellular biology
— id: 93473, year: 2004, vol: 24, page: 407, stat: Journal Article,

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
Karaghiosoff, Marina; Steinborn, Ralf; Kovarik, Pavel; Kriegshauser, Gernot; Baccarini, Manuela; Donabauer, Birgit; Reichart, Ursula; Kolbe, Thomas; Bogdan, Christian; Leanderson, Tomas; Levy, David; Decker, Thomas; Muller, Mathias
2003 May;4(5):471-477, Nature immunology
— id: 650232, year: 2003, vol: 4, page: 471, stat: Journal Article,

Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity
Levy, David E; Marie, Isabelle; Prakash, Arun
2003 Feb;15(1):52-58, Current opinion in immunology
— id: 39347, year: 2003, vol: 15, page: 52, stat: Journal Article,

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth
Rankin, Erinn B; Yu, Duonan; Jiang, Jiu; Shen, Hao; Pearce, Edward J; Goldschmidt, Michael H; Levy, David E; Golovkina, Tatyana V; Hunter, Christopher A; Thomas-Tikhonenko, Andrei
2003 Nov-Dec;2(6):687-693, Cancer biology & therapy
— id: 42153, year: 2003, vol: 2, page: 687, stat: Journal Article,

The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex
Usacheva, Anna; Tian, Xinyong; Sandoval, Raudel; Salvi, Debra; Levy, David; Colamonici, Oscar R
2003 Sep 15;171(6):2989-2994, Journal of immunology
— id: 138939, year: 2003, vol: 171, page: 2989, stat: Journal Article,

STAT1 and STAT3 activation during the course of experimental arthritis
De Hooge, ASK; Van De Loo, FAJ; Kolbe, T; Mueller, M; Levy, DE; Bennink, M; Arntzl, OJ; Van Den Berg, WB
2002 SEP ;46(9):S250-S250, Arthritis & rheumatism
— id: 37120, year: 2002, vol: 46, page: S250, stat: Journal Article,

Role of nucleoporin induction in releasing an mRNA nuclear export block
Enninga, Jost; Levy, David E; Blobel, Gunter; Fontoura, Beatriz M A
2002 Feb 22;295(5559):1523-1525, Science
— id: 93477, year: 2002, vol: 295, page: 1523, stat: Journal Article,

Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli
Humphreys, Robin C; Bierie, Brian; Zhao, Ling; Raz, Regina; Levy, David; Hennighausen, Lothar
2002 Sep;143(9):3641-3650, Endocrinology
— id: 106996, year: 2002, vol: 143, page: 3641, stat: Journal Article,

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
Lee, Chien-kuo; Raz, Regina; Gimeno, Ramon; Gertner, Rachel; Wistinghausen, Birte; Takeshita, Kenichi; DePinho, Ronald A; Levy, David E
2002 Jul;17(1):63-72, Immunity
— id: 32457, year: 2002, vol: 17, page: 63, stat: Journal Article,

Whence interferon? Variety in the production of interferon in response to viral infection
Levy, David E
2002 Feb 18;195(4):F15-F18, Journal of experimental medicine
— id: 39705, year: 2002, vol: 195, page: F15, stat: Journal Article,

Stats: transcriptional control and biological impact
Levy, David E; Darnell, J E Jr
2002 Sep;3(9):651-662, Nature reviews. Molecular cell biology
— id: 39597, year: 2002, vol: 3, page: 651, stat: Journal Article,

What does Stat3 do?
Levy, David E; Lee, Chien-kuo
2002 May;109(9):1143-1148, Journal of clinical investigation
— id: 39652, year: 2002, vol: 109, page: 1143, stat: Journal Article,

Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback
Levy, David E; Marie, Isabelle; Smith, Eric; Prakash, Arun
2002 Jan;22(1):87-93, Journal of interferon & cytokine research
— id: 39713, year: 2002, vol: 22, page: 87, stat: Journal Article,

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff
Paulson, Matthew; Press, Carolyn; Smith, Eric; Tanese, Naoko; Levy, David E
2002 Feb;4(2):140-147, Nature cell biology
— id: 25648, year: 2002, vol: 4, page: 140, stat: Journal Article,

Cost-effectiveness of ancrod treatment of acute ischaemic stroke: results from the Stroke Treatment with Ancrod Trial (STAT)
Samsa, Gregory P; Matchar, David B; Williams, G Rhys; Levy, David E
2002 Feb;8(1):61-70, Journal of evaluation in clinical practice
— id: 93476, year: 2002, vol: 8, page: 61, stat: Journal Article,

Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes
Stockinger, Silvia; Materna, Tilo; Stoiber, Dagmar; Bayr, Lourdes; Steinborn, Ralf; Kolbe, Thomas; Unger, Hermann; Chakraborty, Trinad; Levy, David E; Muller, Mathias; Decker, Thomas
2002 Dec 1;169(11):6522-6529, Journal of immunology
— id: 93474, year: 2002, vol: 169, page: 6522, stat: Journal Article,

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
Zamo, Alberto; Chiarle, Roberto; Piva, Roberto; Howes, Jennifer; Fan, Yan; Chilosi, Marco; Levy, David E; Inghirami, Giorgio
2002 Feb 7;21(7):1038-1047, Oncogene
— id: 27551, year: 2002, vol: 21, page: 1038, stat: Journal Article,

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation
Zhu, Fan Xiu; King, Sonya M; Smith, Eric J; Levy, David E; Yuan, Yan
2002 Apr 16;99(8):5573-5578, Proceedings of the National Academy of Sciences of the United States of America
— id: 93475, year: 2002, vol: 99, page: 5573, stat: Journal Article,

Cooperation between STAT3 and c-jun suppresses Fas transcription
Ivanov, V N; Bhoumik, A; Krasilnikov, M; Raz, R; Owen-Schaub, L B; Levy, D; Horvath, C M; Ronai, Z
2001 Mar;7(3):517-528, Molecular cell
— id: 106997, year: 2001, vol: 7, page: 517, stat: Journal Article,

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
Kovarik, P; Mangold, M; Ramsauer, K; Heidari, H; Steinborn, R; Zotter, A; Levy, D E; Muller, M; Decker, T
2001 Jan 15;20(1-2):91-100, EMBO journal
— id: 138937, year: 2001, vol: 20, page: 91, stat: Journal Article,

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Levy DE; Garcia-Sastre A
2001 Jun;12(2-3):143-156, Cytokine & growth factor reviews
— id: 20700, year: 2001, vol: 12, page: 143, stat: Journal Article,

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
Polyak, S J; Khabar, K S; Paschal, D M; Ezelle, H J; Duverlie, G; Barber, G N; Levy, D E; Mukaida, N; Gretch, D R
2001 Jul;75(13):6095-6106, Journal of virology
— id: 138938, year: 2001, vol: 75, page: 6095, stat: Journal Article,

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
Sahni M; Raz R; Coffin JD; Levy D; Basilico C
2001 Jun;128(11):2119-2129, Development
— id: 26721, year: 2001, vol: 128, page: 2119, stat: Journal Article,

IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein
Smith EJ; Marie I; Prakash A; Garcia-Sastre A; Levy DE
2001 Mar 23;276(12):8951-8957, Journal of biological chemistry
— id: 21260, year: 2001, vol: 276, page: 8951, stat: Journal Article,

Type I IFN modulates innate and specific antiviral immunity
Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE
2000 Apr 15;164(8):4220-4228, Journal of immunology
— id: 11766, year: 2000, vol: 164, page: 4220, stat: Journal Article,

Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages
Goodman AR; Levy DE; Reis LF; Vilcek J
2000 Mar;67(3):387-395, Journal of leukocyte biology
— id: 11789, year: 2000, vol: 67, page: 387, stat: Journal Article,

Distinct requirements for IFNs and STAT1 in NK cell function
Lee CK; Rao DT; Gertner R; Gimeno R; Frey AB; Levy DE
2000 Oct 1;165(7):3571-3577, Journal of immunology
— id: 20292, year: 2000, vol: 165, page: 3571, stat: Journal Article,

STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma
Lee CK; Smith E; Gimeno R; Gertner R; Levy DE
2000 Feb 1;164(3):1286-1292, Journal of immunology
— id: 8573, year: 2000, vol: 164, page: 1286, stat: Journal Article,

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
Levy DE; Gilliland DG
2000 May 15;19(21):2505-2510, Oncogene
— id: 11657, year: 2000, vol: 19, page: 2505, stat: Journal Article,

Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain
Marie I; Smith E; Prakash A; Levy DE
2000 Dec;20(23):8803-8814, Molecular & cellular biology
— id: 39519, year: 2000, vol: 20, page: 8803, stat: Journal Article,

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
Schwaller J; Parganas E; Wang D; Cain D; Aster JC; Williams IR; Lee CK; Gerthner R; Kitamura T; Frantsve J; Anastasiadou E; Loh ML; Levy DE; Ihle JN; Gilliland DG
2000 Sep;6(3):693-704, Molecular cell
— id: 18491, year: 2000, vol: 6, page: 693, stat: Journal Article,

Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression
Weiden M; Tanaka N; Qiao Y; Zhao BY; Honda Y; Nakata K; Canova A; Levy DE; Rom WN; Pine R
2000 Aug 15;165(4):2028-2039, Journal of immunology
— id: 11568, year: 2000, vol: 165, page: 2028, stat: Journal Article,

Mechanism of STAT3 activation by insulin-like growth factor I receptor
Zong, C S; Chan, J; Levy, D E; Horvath, C; Sadowski, H B; Wang, L H
2000 May 19;275(20):15099-15105, Journal of biological chemistry
— id: 138936, year: 2000, vol: 275, page: 15099, stat: Journal Article,

Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes
Lee CK; Gimeno R; Levy DE
1999 Nov 15;190(10):1451-1464, Journal of experimental medicine
— id: 6240, year: 1999, vol: 190, page: 1451, stat: Journal Article,

Physiological significance of STAT proteins: investigations through gene disruption in vivo
Levy DE
1999 Sep;55(12):1559-1567, Cellular & molecular life sciences: CMLS
— id: 11944, year: 1999, vol: 55, page: 1559, stat: Journal Article,

The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3
Nadeau OW; Domanski P; Usacheva A; Uddin S; Platanias LC; Pitha P; Raz R; Levy D; Majchrzak B; Fish E; Colamonici OR
1999 Feb 12;274(7):4045-4052, Journal of biological chemistry
— id: 7991, year: 1999, vol: 274, page: 4045, stat: Journal Article,

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
Paulson M; Pisharody S; Pan L; Guadagno S; Mui AL; Levy DE
1999 Sep 3;274(36):25343-25349, Journal of biological chemistry
— id: 8480, year: 1999, vol: 274, page: 25343, stat: Journal Article,

Essential role of STAT3 for embryonic stem cell pluripotency
Raz R; Lee CK; Cannizzaro LA; d'Eustachio P; Levy DE
1999 Mar 16;96(6):2846-2851, Proceedings of the National Academy of Sciences of the United States of America
— id: 8219, year: 1999, vol: 96, page: 2846, stat: Journal Article,

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
Sahni M; Ambrosetti DC; Mansukhani A; Gertner R; Levy D; Basilico C
1999 Jun 1;13(11):1361-1366, Genes & development
— id: 12005, year: 1999, vol: 13, page: 1361, stat: Journal Article,

Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo
Fernandez-Sesma, A; Peluso, R W; Bai, X; Schulman, J L; Levy, D E; Moran, T M
1998 Feb 15;160(4):1841-1849, Journal of immunology
— id: 138966, year: 1998, vol: 160, page: 1841, stat: Journal Article,

The role of interferon in influenza virus tissue tropism
Garcia-Sastre A; Durbin RK; Zheng H; Palese P; Gertner R; Levy DE; Durbin JE
1998 Nov;72(11):8550-8558, Journal of virology
— id: 7576, year: 1998, vol: 72, page: 8550, stat: Journal Article,

Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
Garcia-Sastre, A; Egorov, A; Matassov, D; Brandt, S; Levy, D E; Durbin, J E; Palese, P; Muster, T
1998 Dec 20;252(2):324-330, Virology
— id: 138967, year: 1998, vol: 252, page: 324, stat: Journal Article,

Analysis of interferon-regulated proteins binding the interferon-alpha-stimulated response element
Levy DE
1998 Jul;15(3):167-174, Methods
— id: 7387, year: 1998, vol: 15, page: 167, stat: Journal Article,

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
Marie I; Durbin JE; Levy DE
1998 Nov 16;17(22):6660-6669, EMBO journal
— id: 7964, year: 1998, vol: 17, page: 6660, stat: Journal Article,

Essential role of STAT3 for embryonic stem cell growth
Raz, R; D'Eustachio, P; Kennizzaro, L; Levy, DE
1998 SEP ;9(3):328-328, European cytokine network
— id: 53660, year: 1998, vol: 9, page: 328, stat: Journal Article,

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation
Zheng P; Guo Y; Niu Q; Levy DE; Dyck JA; Lu S; Sheiman LA; Liu Y
1998 Nov 26;396(6709):373-376, Nature
— id: 7473, year: 1998, vol: 396, page: 373, stat: Journal Article,

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA
Bluyssen HA; Levy DE
1997 Feb 14;272(7):4600-4605, Journal of biological chemistry
— id: 12382, year: 1997, vol: 272, page: 4600, stat: Journal Article,

Regulation of interferon-alpha responsiveness by the duration of Janus kinase activity
Lee CK; Bluyssen HA; Levy DE
1997 Aug 29;272(35):21872-21877, Journal of biological chemistry
— id: 7193, year: 1997, vol: 272, page: 21872, stat: Journal Article,

The house that Jak/Stat built
Levy DE
1997 Mar;8(1):81-90, Cytokine & growth factor reviews
— id: 7197, year: 1997, vol: 8, page: 81, stat: Journal Article,

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons
Matikainen, S; Ronni, T; Lehtonen, A; Sareneva, T; Melen, K; Nordling, S; Levy, D E; Julkunen, I
1997 Jun;8(6):687-698, Cell growth & differentiation
— id: 138965, year: 1997, vol: 8, page: 687, stat: Journal Article,

ISGF3 gamma p48, a specificity switch for interferon activated transcription factors
Bluyssen AR; Durbin JE; Levy DE
1996 Jun;7(1):11-17, Cytokine & growth factor reviews
— id: 12594, year: 1996, vol: 7, page: 11, stat: Journal Article,

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
Durbin JE; Hackenmiller R; Simon MC; Levy DE
1996 Feb 9;84(3):443-450, Cell
— id: 6903, year: 1996, vol: 84, page: 443, stat: Journal Article,

Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
Leaman, D W; Pisharody, S; Flickinger, T W; Commane, M A; Schlessinger, J; Kerr, I M; Levy, D E; Stark, G R
1996 Jan;16(1):369-375, Molecular & cellular biology
— id: 138964, year: 1996, vol: 16, page: 369, stat: Journal Article,

Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells
Levy, J B; Schindler, C; Raz, R; Levy, D E; Baron, R; Horowitz, M C
1996 Apr;137(4):1159-1165, Endocrinology
— id: 106998, year: 1996, vol: 137, page: 1159, stat: Journal Article,

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses
Bluyssen HA; Muzaffar R; Vlieststra RJ; van der Made AC; Leung S; Stark GR; Kerr IM; Trapman J; Levy DE
1995 Jun 6;92(12):5645-5649, Proceedings of the National Academy of Sciences of the United States of America
— id: 12764, year: 1995, vol: 92, page: 5645, stat: Journal Article,

STRUCTURE-FUNCTION ANALYSIS OF ISGF3 COMPLEX-FORMATION
BLUYSSEN, HAR; RAZ, R; LEVY, DE
1995 JAN 5 ;336(3):30-30, Journal of cellular biochemistry
— id: 87348, year: 1995, vol: 336, page: 30, stat: Journal Article,

Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone
Campbell, G S; Meyer, D J; Raz, R; Levy, D E; Schwartz, J; Carter-Su, C
1995 Feb 24;270(8):3974-3979, Journal of biological chemistry
— id: 106999, year: 1995, vol: 270, page: 3974, stat: Journal Article,

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity
Gouilleux, F; Pallard, C; Dusanter-Fourt, I; Wakao, H; Haldosen, L A; Norstedt, G; Levy, D; Groner, B
1995 May 1;14(9):2005-2013, EMBO journal
— id: 138960, year: 1995, vol: 14, page: 2005, stat: Journal Article,

Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6
Henttinen, T; Levy, D E; Silvennoinen, O; Hurme, M
1995 Nov 15;155(10):4582-4587, Journal of immunology
— id: 138958, year: 1995, vol: 155, page: 4582, stat: Journal Article,

INTERFERON INDUCTION OF GENE-EXPRESSION THROUGH THE JAK-STAT PATHWAY
LEVY, DE
1995 JUN ;6(3):181-189, Seminars in virology
— id: 87242, year: 1995, vol: 6, page: 181, stat: Journal Article,

Thrombopoietin activates a STAT5-like factor in hematopoietic cells
Pallard, C; Gouilleux, F; Benit, L; Cocault, L; Souyri, M; Levy, D; Groner, B; Gisselbrecht, S; Dusanter-Fourt, I
1995 Jun 15;14(12):2847-2856, EMBO journal
— id: 138961, year: 1995, vol: 14, page: 2847, stat: Journal Article,

Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness
Raz R; Cheung K; Ling L; Levy DE
1995 Mar;21(2):139-145, Somatic cell & molecular genetics
— id: 12801, year: 1995, vol: 21, page: 139, stat: Journal Article,

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family
Bovolenta, C; Driggers, P H; Marks, M S; Medin, J A; Politis, A D; Vogel, S N; Levy, D E; Sakaguchi, K; Appella, E; Coligan, J E
1994 May 24;91(11):5046-5050, Proceedings of the National Academy of Sciences of the United States of America
— id: 138971, year: 1994, vol: 91, page: 5046, stat: Journal Article,

Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines
Lamb, P; Kessler, L V; Suto, C; Levy, D E; Seidel, H M; Stein, R B; Rosen, J
1994 Apr 15;83(8):2063-2071, Blood
— id: 138963, year: 1994, vol: 83, page: 2063, stat: Journal Article,

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
Raz R; Durbin JE; Levy DE
1994 Sep 30;269(39):24391-24395, Journal of biological chemistry
— id: 12890, year: 1994, vol: 269, page: 24391, stat: Journal Article,

Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors
Rothman P; Kreider B; Azam M; Levy D; Wegenka U; Eilers A; Decker T; Horn F; Kashleva H; Ihle J; et al.
1994 Sep;1(6):457-468, Immunity
— id: 18492, year: 1994, vol: 1, page: 457, stat: Journal Article,

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene
Seegert, D; Strehlow, I; Klose, B; Levy, D E; Schindler, C; Decker, T
1994 Mar 18;269(11):8590-8595, Journal of biological chemistry
— id: 138962, year: 1994, vol: 269, page: 8590, stat: Journal Article,

The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors
Parrington, J; Rogers, N C; Gewert, D R; Pine, R; Veals, S A; Levy, D E; Stark, G R; Kerr, I M
1993 Jun 15;214(3):617-626, European journal of biochemistry
— id: 138959, year: 1993, vol: 214, page: 617, stat: Journal Article,

Interferon-induced nuclear signalling by Jak protein tyrosine kinases
Silvennoinen O; Ihle JN; Schlessinger J; Levy DE
1993 Dec 9;366(6455):583-585, Nature
— id: 18493, year: 1993, vol: 366, page: 583, stat: Journal Article,

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation [see comments]
Silvennoinen O; Schindler C; Schlessinger J; Levy DE
1993 Sep 24;261(5129):1736-1739, Science
— id: 13070, year: 1993, vol: 261, page: 1736, stat: Journal Article,

Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity
Veals SA; Santa Maria T; Levy DE
1993 Jan;13(1):196-206, Molecular & cellular biology
— id: 13309, year: 1993, vol: 13, page: 196, stat: Journal Article,

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins
Veals SA; Schindler C; Leonard D; Fu XY; Aebersold R; Darnell JE Jr; Levy DE
1992 Aug;12(8):3315-3324, Molecular & cellular biology
— id: 13485, year: 1992, vol: 12, page: 3315, stat: Journal Article,

Protein kinase activity required for an early step in interferon-alpha signaling
Kessler, D S; Levy, D E
1991 Dec 5;266(34):23471-23476, Journal of biological chemistry
— id: 138968, year: 1991, vol: 266, page: 23471, stat: Journal Article,

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains
Fu XY; Kessler DS; Veals SA; Levy DE; Darnell JE Jr
1990 Nov;87(21):8555-8559, Proceedings of the National Academy of Sciences of the United States of America
— id: 63335, year: 1990, vol: 87, page: 8555, stat: Journal Article,

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator
Kessler, D S; Veals, S A; Fu, X Y; Levy, D E
1990 Oct;4(10):1753-1765, Genes & development
— id: 138969, year: 1990, vol: 4, page: 1753, stat: Journal Article,

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3
Levy, D E; Lew, D J; Decker, T; Kessler, D S; Darnell, J E Jr
1990 Apr;9(4):1105-1111, EMBO journal
— id: 138946, year: 1990, vol: 9, page: 1105, stat: Journal Article,

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either
Pine, R; Decker, T; Kessler, D S; Levy, D E; Darnell, J E Jr
1990 Jun;10(6):2448-2457, Molecular & cellular biology
— id: 138947, year: 1990, vol: 10, page: 2448, stat: Journal Article,

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein
Decker, T; Lew, D J; Cheng, Y S; Levy, D E; Darnell, J E Jr
1989 Jul;8(7):2009-2014, EMBO journal
— id: 138950, year: 1989, vol: 8, page: 2009, stat: Journal Article,

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro
Levy DE; Kessler DS; Pine R; Darnell JE Jr
1989 Sep;3(9):1362-1371, Genes & development
— id: 10512, year: 1989, vol: 3, page: 1362, stat: Journal Article,

Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation
Raj, N B; Engelhardt, J; Au, W C; Levy, D E; Pitha, P M
1989 Oct 5;264(28):16658-16666, Journal of biological chemistry
— id: 138951, year: 1989, vol: 264, page: 16658, stat: Journal Article,

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes
Kessler, D S; Levy, D E; Darnell, J E Jr
1988 Nov;85(22):8521-8525, Proceedings of the National Academy of Sciences of the United States of America
— id: 138949, year: 1988, vol: 85, page: 8521, stat: Journal Article,

Cells resistant to interferon are defective in activation of a promoter-binding factor
Kessler, D S; Pine, R; Pfeffer, L M; Levy, D E; Darnell, J E Jr
1988 Dec 1;7(12):3779-3783, EMBO journal
— id: 138952, year: 1988, vol: 7, page: 3779, stat: Journal Article,

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control
Levy, D E; Kessler, D S; Pine, R; Reich, N; Darnell, J E Jr
1988 Apr;2(4):383-393, Genes & development
— id: 138955, year: 1988, vol: 2, page: 383, stat: Journal Article,

Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it
Levy, D; Reich, N; Kessler, D; Pine, R; Darnell, J E Jr
1988 ;53 Pt 2:799-802, Cold Spring Harbor symposia on quantitative biology
— id: 138954, year: 1988, vol: 53 Pt 2, page: 799, stat: Journal Article,

Transcriptional stimulation by CaPO4-DNA precipitates
Pine, R; Levy, D E; Reich, N; Darnell, J E Jr
1988 Feb 25;16(4):1371-1378, Nucleic acids research
— id: 138953, year: 1988, vol: 16, page: 1371, stat: Journal Article,

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products
Reich, N; Pine, R; Levy, D; Darnell, J E Jr
1988 Jan;62(1):114-119, Journal of virology
— id: 138948, year: 1988, vol: 62, page: 114, stat: Journal Article,

Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients
Levy DE; Sidtis JJ; Rottenberg DA; Jarden JO; Strother SC; Dhawan V; Ginos JZ; Tramo MJ; Evans AC; Plum F
1987 Dec;22(6):673-682, Annals of neurology
— id: 60874, year: 1987, vol: 22, page: 673, stat: Journal Article,

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element
Reich, N; Evans, B; Levy, D; Fahey, D; Knight, E Jr; Darnell, J E Jr
1987 Sep;84(18):6394-6398, Proceedings of the National Academy of Sciences of the United States of America
— id: 138957, year: 1987, vol: 84, page: 6394, stat: Journal Article,

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region
Levy, D; Larner, A; Chaudhuri, A; Babiss, L E; Darnell, J E Jr
1986 Dec;83(23):8929-8933, Proceedings of the National Academy of Sciences of the United States of America
— id: 138956, year: 1986, vol: 83, page: 8929, stat: Journal Article,

Outcome from severe neurological illness; should it influence medical decisions?
Plum, Fred; Levy, David E
1979 ;No. 69:267-277, CIBA Foundation symposium
— id: 93478, year: 1979, vol: No. 69, page: 267, stat: Journal Article,