Jeremy S. Dasen

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Jeremy S. Dasen, Ph.D.

Associate Professor;
Department of Neuroscience and Physiology (Neuro/Phys)

Contact Info

Address
522 First Avenue
SML504 Floor 5th Room 504
Smilow Research Building
New York, NY 10016

212-263-9109
212-263-9170
Jeremy.Dasen@nyumc.org


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Education

1994 — University of CA San Diego, Graduate Education
2001-2006 — Columbia University, PostDoctoral Training

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Research Interests

Research in the lab focuses on defining the developmental programs that direct the assembly of neural circuits. The ability to move is a simple behavior displayed by all organisms, and many of the circuits essential for locomotor behaviors reside within the spinal cord. The relatively well defined anatomical and physiological features of spinal neurons provide an attractive system to explore the early steps in neural circuit assembly. We use genetic manipulations in chick and mouse to define how neural identity influences the specificity of connections between neurons with their targets. We have found that a large group of transcription factors belonging to Hox gene family are critical for the selective connections made between motor neurons in the spinal cord and their targets in the periphery. The patterned expression of Hox proteins by other classes of neurons, such as sensory neurons and interneurons, suggests Hox proteins may contribute to more generally to the formation of locomotor circuits. By further defining the basic logic of the Hox transcriptional networks involved in neuronal fate specification, and the identity of the target effectors of these nuclear proteins, we hope to be able to better understand the individual molecular elements that control neural circuit assembly.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Evolving hox activity profiles govern diversity in locomotor systems
Jung, Heekyung; Mazzoni, Esteban O; Soshnikova, Natalia; Hanley, Olivia; Venkatesh, Byrappa; Duboule, Denis; Dasen, Jeremy S
2014 Apr;29(2):171-187, Developmental cell
— id: 960142, year: 2014, vol: 29, page: 171, stat: Journal Article,

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor
Biehs, Brian; Hu, Jimmy Kuang-Hsien; Strauli, Nicolas B; Sangiorgi, Eugenio; Jung, Heekyung; Heber, Ralf-Peter; Ho, Sunita; Goodwin, Alice F; Dasen, Jeremy S; Capecchi, Mario R; Klein, Ophir D
2013 Jun;:846-852, Nature cell biology
— id: 371822, year: 2013, vol: , page: 846, stat: Journal Article,

Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis
Boucherat, Olivier; Montaron, Severine; Berube-Simard, Felix-Antoine; Aubin, Josee; Philippidou, Polyxeni; Wellik, Deneen M; Dasen, Jeremy S; Jeannotte, Lucie
2013 Jun;304(12):L817-L830, American journal of physiology. Lung cellular & molecular physiology
— id: 668312, year: 2013, vol: 304, page: L817, stat: Journal Article,

Long Noncoding RNAs in Development: Solidifying the Lncs to Hox Gene Regulation
Dasen, Jeremy S
2013 Oct;5(1):1-2, Cell reports
— id: 586392, year: 2013, vol: 5, page: 1, stat: Journal Article,

Genetic and functional modularity of hox activities in the specification of limb-innervating motor neurons
Lacombe, Julie; Hanley, Olivia; Jung, Heekyung; Philippidou, Polyxeni; Surmeli, Gulsen; Grinstein, Jonathan; Dasen, Jeremy S
2013 Jan;9(1):e1003184-e1003184 e1003184, PLoS Genetics
— id: 214142, year: 2013, vol: 9, page: e1003184, stat: Journal Article,

Hox genes: choreographers in neural development, architects of circuit organization
Philippidou, Polyxeni; Dasen, Jeremy S
2013 Oct;80(1):12-34, Neuron
— id: 574112, year: 2013, vol: 80, page: 12, stat: Journal Article,

Polycomb repressive complex 1 activities determine the columnar organization of motor neurons
Golden, Molly G; Dasen, Jeremy S
2012 Oct;26(19):2236-2250, Genes & development
— id: 179097, year: 2012, vol: 26, page: 2236, stat: Journal Article,

Sustained Hox5 gene activity is required for respiratory motor neuron development
Philippidou, Polyxeni; Walsh, Carolyn M; Aubin, Josee; Jeannotte, Lucie; Dasen, Jeremy S
2012 Nov;15(12):1636-1644, Nature neuroscience
— id: 184932, year: 2012, vol: 15, page: 1636, stat: Journal Article,

Global control of motor neuron topography mediated by the repressive actions of a single hox gene
Jung, Heekyung; Lacombe, Julie; Mazzoni, Esteban O; Liem, Karel F Jr; Grinstein, Jonathan; Mahony, Shaun; Mukhopadhyay, Debnath; Gifford, David K; Young, Richard A; Anderson, Kathryn V; Wichterle, Hynek; Dasen, Jeremy S
2010 Sep 9;67(5):781-796, Neuron
— id: 112207, year: 2010, vol: 67, page: 781, stat: Journal Article,

Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation
Peljto, Mirza; Dasen, Jeremy S; Mazzoni, Esteban O; Jessell, Thomas M; Wichterle, Hynek
2010 Sep 3;7(3):355-366, Cell stem cell
— id: 131864, year: 2010, vol: 7, page: 355, stat: Journal Article,

Chapter 4 transcriptional networks in the early development of sensory-motor circuits
Dasen, Jeremy S
2009 ;87:119-148, Current topics in developmental biology
— id: 100047, year: 2009, vol: 87, page: 119, stat: Journal Article,

Hox networks and the origins of motor neuron diversity
Dasen, Jeremy S; Jessell, Thomas M
2009 ;88:169-200, Current topics in developmental biology
— id: 101333, year: 2009, vol: 88, page: 169, stat: Journal Article,

Transcriptional mechanisms controlling motor neuron diversity and connectivity
Dalla Torre di Sanguinetto, Simon A; Dasen, Jeremy S; Arber, Silvia
2008 Feb;18(1):36-43, Current opinion in neurobiology
— id: 96292, year: 2008, vol: 18, page: 36, stat: Journal Article,

Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1
Dasen, Jeremy S; De Camilli, Alessandro; Wang, Bin; Tucker, Philip W; Jessell, Thomas M
2008 Jul 25;134(2):304-316, Cell
— id: 80621, year: 2008, vol: 134, page: 304, stat: Journal Article,

A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity
Dasen, Jeremy S; Tice, Bonnie C; Brenner-Morton, Susan; Jessell, Thomas M
2005 Nov 4;123(3):477-491, Cell
— id: 68375, year: 2005, vol: 123, page: 477, stat: Journal Article,

Motor neuron columnar fate imposed by sequential phases of Hox-c activity
Dasen, Jeremy S; Liu, Jeh-Ping; Jessell, Thomas M
2003 Oct 30;425(6961):926-933, Nature
— id: 68376, year: 2003, vol: 425, page: 926, stat: Journal Article,

Paired-like repression/activation in pituitary development
Olson, Lorin E; Dasen, Jeremy S; Ju, Bong Gun; Tollkuhn, Jessica; Rosenfeld, Michael G
2003 ;58:249-261, Recent progress in hormone research
— id: 68377, year: 2003, vol: 58, page: 249, stat: Journal Article,

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis
Dasen, J S; Barbera, J P; Herman, T S; Connell, S O; Olson, L; Ju, B; Tollkuhn, J; Baek, S H; Rose, D W; Rosenfeld, M G
2001 Dec 1;15(23):3193-3207, Genes & development
— id: 68378, year: 2001, vol: 15, page: 3193, stat: Journal Article,

Signaling and transcriptional mechanisms in pituitary development
Dasen, J S; Rosenfeld, M G
2001 ;24:327-355, Annual review of neuroscience
— id: 68379, year: 2001, vol: 24, page: 327, stat: Journal Article,

Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types
Dasen, J S; O'Connell, S M; Flynn, S E; Treier, M; Gleiberman, A S; Szeto, D P; Hooshmand, F; Aggarwal, A K; Rosenfeld, M G
1999 May 28;97(5):587-598, Cell
— id: 68382, year: 1999, vol: 97, page: 587, stat: Journal Article,

Combinatorial codes in signaling and synergy: lessons from pituitary development
Dasen, J S; Rosenfeld, M G
1999 Oct;9(5):566-574, Current opinion in genetics & development
— id: 68381, year: 1999, vol: 9, page: 566, stat: Journal Article,

Signaling mechanisms in pituitary morphogenesis and cell fate determination
Dasen, J S; Rosenfeld, M G
1999 Dec;11(6):669-677, Current opinion in cell biology
— id: 68380, year: 1999, vol: 11, page: 669, stat: Journal Article,

Combinatiorial mechanisms in pituitary morphogenesis and cell fate specification
Dasen, Jeremy S
[S.l. : s.n.], 1999,
— id: 2223, year: 1999, vol: , page: , stat: ,

Factor-specific modulation of CREB-binding protein acetyltransferase activity
Perissi, V; Dasen, J S; Kurokawa, R; Wang, Z; Korzus, E; Rose, D W; Glass, C K; Rosenfeld, M G
1999 Mar 30;96(7):3652-3657, Proceedings of the National Academy of Sciences of the United States of America
— id: 68383, year: 1999, vol: 96, page: 3652, stat: Journal Article,

Mutations in PROP1 cause familial combined pituitary hormone deficiency
Wu, W; Cogan, J D; Pfaffle, R W; Dasen, J S; Frisch, H; O'Connell, S M; Flynn, S E; Brown, M R; Mullis, P E; Parks, J S; Phillips, J A 3rd; Rosenfeld, M G
1998 Feb;18(2):147-149, Nature genetics
— id: 68385, year: 1998, vol: 18, page: 147, stat: Journal Article,

Signal-specific co-activator domain requirements for Pit-1 activation
Xu, L; Lavinsky, R M; Dasen, J S; Flynn, S E; McInerney, E M; Mullen, T M; Heinzel, T; Szeto, D; Korzus, E; Kurokawa, R; Aggarwal, A K; Rose, D W; Glass, C K; Rosenfeld, M G
1998 Sep 17;395(6699):301-306, Nature
— id: 68384, year: 1998, vol: 395, page: 301, stat: Journal Article,

Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter
Bachman, N J; Yang, T L; Dasen, J S; Ernst, R E; Lomax, M I
1996 Sep 1;333(1):152-162, Archives of biochemistry & biophysics. ABB
— id: 68387, year: 1996, vol: 333, page: 152, stat: Journal Article,

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism
Sornson, M W; Wu, W; Dasen, J S; Flynn, S E; Norman, D J; O'Connell, S M; Gukovsky, I; Carriere, C; Ryan, A K; Miller, A P; Zuo, L; Gleiberman, A S; Andersen, B; Beamer, W G; Rosenfeld, M G
1996 Nov 28;384(6607):327-333, Nature
— id: 68386, year: 1996, vol: 384, page: 327, stat: Journal Article,