Wei Dai

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Wei Dai, Ph.D.

Departments of Environmental Medicine and Biochemistry and Molecular Pharmacology

Contact Info

57 Old Forge Road
Floor 1
Sterling Forest
Tuxedo, NY 10987


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1983-1988 — Purdue University, Graduate Education

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Research Summary

Progression of the cell cycle is tightly regulated in order to ensure that genetic integrity is maintained and genetic information is passed correctly to daughter cells. Extensive research over the past two decades has revealed the existence of important surveillance mechanisms (referred to as checkpoints) that regulate cell cycle progression. These checkpoints monitor specific cell cycle?related processes and block cell cycle progression until these processes are completed with high fidelity. Cancer results from damage to multiple genes controlling cell division or cell death. An underlying genetic instability is required for the generation of multiple lesions that are characteristic of cancer. Genetic instability could be manifested as alterations in chromosome number as well as translocations, deletions, and insertions. Aneuploidy is frequently present in many types of tumor cell. A loss of the spindle checkpoint function and the control of anaphase entry appear to be causes leading to gross aneuploidy, a condition from which cells with an advantage for tumor growth will be selected. Thus, studying the mechanism underlying cohesion of sister chromatids and centrioles has the potential for identifying new targets for rational designing of anti-cancer drugs. In addition, a better understanding of biochemical pathways controlling checkpoint-induced programmed cell death may help us to better therapeutically induce resistant tumor cells to undergo apoptosis. We have been studying the function of molecular components in cell cycle regulation and in suppression tumorigenesis. Our recent studies on the function of Plk1, BubR1, and Sgo1 reveal that these cell cycle checkpoint regulators play an important role in the maintenance of genomic stability and suppression of tumor formation. We have obtained a series of mice with ablation of checkpoint genes. We believe these mice will be excellent animal models with which the effect of environmental agents on cacinogenesis can be studied.

Research Interests

Cell Cycle, Checkpoint Control, Mitosis, Genomic Instability, Carcinogenesis

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All data from NYU Health Sciences Library Faculty Bibliography — -


Cdh1, a substrate recruiting component of APC/C ubiquitin E3 ligase, specifically interacts with PTEN and promotes its removal from chromatin
Choi, Byeong Hyeok; Pagano, Michele; Huang, Chuanshu; Dai, Wei
2014 May;:17951-17959, Journal of biological chemistry
— id: 988602, year: 2014, vol: , page: 17951, stat: Journal Article,

Plk1 phosphorylates PTEN and regulates its mitotic activity during the cell cycle
Choi, Byeong; Pagano, Michele; Dai, Wei
2014 Apr;:14066-14074, Journal of biological chemistry
— id: 988612, year: 2014, vol: , page: 14066, stat: Journal Article,

Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability
Nishioka, T; Luo, L-Y; Shen, L; He, H; Mariyannis, A; Dai, W; Chen, C
2014 Apr;110(7):1785-1792, British journal of cancer
— id: 997072, year: 2014, vol: 110, page: 1785, stat: Journal Article,

Anti-tumor effect of a novel soluble recombinant human endostatin: administered as a single agent or in combination with chemotherapy agents in mouse tumor models
Ren, Zhihua; Wang, Yanan; Jiang, Wenhong; Dai, Wei; Jiang, Yongping
2014 ;9(9):e107823-e107823 e107823, PLoS one
— id: 1209622, year: 2014, vol: 9, page: e107823, stat: Journal Article,

CCCTC-binding factor mediates effects of glucose on beta cell survival
Tsui, S; Dai, W; Lu, L
2014 Feb;47(1):28-37, Cell proliferation
— id: 782522, year: 2014, vol: 47, page: 28, stat: Journal Article,

Osmotic Stress-induced Phosphorylation of H2AX by Polo-like Kinase 3 Affects Cell Cycle Progression in Human Corneal Epithelial Cells
Wang, Ling; Dai, Wei; Lu, Luo
2014 Oct;289(43):29827-29835, Journal of biological chemistry
— id: 1321852, year: 2014, vol: 289, page: 29827, stat: Journal Article,

Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor
Wu, Meng; Yang, Feikun; Ren, Zhihua; Jiang, Yongping; Ma, Yupo; Chen, Yan; Dai, Wei
2014 May;13(9):1456-1462, Cell cycle
— id: 970012, year: 2014, vol: 13, page: 1456, stat: Journal Article,

Cobalt and Nickel Stabilize Stem Cell Transcription Factor OCT4 through Modulating Its Sumoylation and Ubiquitination
Yao, Yixin; Lu, Yinghua; Chen, Wen-Chi; Jiang, Yongping; Cheng, Tao; Ma, Yupo; Lu, Lou; Dai, Wei
2014 ;9(1):e86620-e86620 e86620, PLoS one
— id: 800172, year: 2014, vol: 9, page: e86620, stat: Journal Article,

High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression
Zuo, Zhenghong; Che, Xun; Wang, Yulei; Li, Bowen; Li, Jingxia; Dai, Wei; Lin, Charles P; Huang, Chuanshu
2014 Sep;5(17):7458-7470, Oncotarget
— id: 1298952, year: 2014, vol: 5, page: 7458, stat: Journal Article,

Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation
Choi, Byeong Hyeok; Chen, Yan; Dai, Wei
2013 Nov;12(21):3442-3447, Cell cycle
— id: 614282, year: 2013, vol: 12, page: 3442, stat: Journal Article,

Nuclear protein IK undergoes dynamic subcellular translocation and forms unique nuclear bodies during the cell cycle
Hu, Liyan; Yang, Feikun; Liu, Xianan; Xu, Dazhong; Dai, Wei
2013 ;1(1):11-11, Biomarker research
— id: 1252162, year: 2013, vol: 1, page: 11, stat: Journal Article,

Enhancing bone marrow regeneration by SALL4 protein
Liao, Wenbin; Aguila, Jerell R; Yao, Yixin; Yang, Jianchang; Zieve, Gary; Jiang, Yongping; Avila, Cecilia; Senzel, Lisa; Lai, Raymond; Xu, Dazhong; Dai, Wei; Ma, Yupo
2013 ;6:84-84, Journal of hematology & oncology
— id: 962892, year: 2013, vol: 6, page: 84, stat: Journal Article,

Consequences of high Chromosome Instability (CIN) in SGO1(Shugoshin1) CIN model mice
Yamada, Hiroshi Y.; Zhang, Yuting; Dai, Wei; Rao, Chinthalapally V.
2013 APR 15;73(8 1 1):-, Cancer research
— id: 853212, year: 2013, vol: 73, page: , stat: Journal Article,

Sumoylation of Sall4B, an essential stem cell transcription factor, regulates its stability, subcellular localization and transcriptional activity
Yang, F; Ma, Y; Dai, W
2013 April 2013;27:-, FASEB journal
— id: 550842, year: 2013, vol: 27, page: , stat: Journal Article,

Epigenomics: Pioneering a New Frontier in Cancer Research
Chervona, Yana; Costa, Max; Dai, Wei
2012 Jan;3:102605-102605, Journal of pharmacogenomics & pharmacoproteomics
— id: 1105232, year: 2012, vol: 3, page: 102605, stat: Journal Article,

Polo-Like Kinase 3, a Novel Regulator of Thrombosis: Positive Regulation of TxA2 Generation, Granular Secretion and Clot Retraction, but Negative Regulation of Integrin Activation
Naik, Meghna Ulhas; Bachman, Brendan; Kostyak, John C.; Dai, Wei; Naik, Ulhas P.
2012 NOV 16;120(21):-, Blood
— id: 227522, year: 2012, vol: 120, page: , stat: Journal Article,

Roles of Polo-like kinase 3 in suppressing tumor angiogenesis
Xu, Dazhong; Wang, Qi; Jiang, Yongping; Zhang, Yanxi; Vega-Saenzdemiera, Eleazar; Osman, Iman; Dai, Wei
2012 ;1(1):5-5, Experimental hematology & oncology
— id: 197492, year: 2012, vol: 1, page: 5, stat: Journal Article,

Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
Yamada, Hiroshi Y; Yao, Yixin; Wang, Xiaoxing; Zhang, Yuting; Huang, Ying; Dai, Wei; Rao, Chinthalapally V
2012 Feb;11(3):479-488, Cell cycle
— id: 158625, year: 2012, vol: 11, page: 479, stat: Journal Article,

BubR1 Is Modified by Sumoylation during Mitotic Progression
Yang, Feikun; Hu, Liyan; Chen, Cheng; Yu, Jianxiu; O'Connell, Christopher B; Khodjakov, Alexey; Pagano, Michele; Dai, Wei
2012 Feb;287(7):4875-4882, Journal of biological chemistry
— id: 157470, year: 2012, vol: 287, page: 4875, stat: Journal Article,

Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing
Yang, Feikun; Huang, Ying; Dai, Wei
2012 Feb;11(4):797-806, Cell cycle
— id: 158691, year: 2012, vol: 11, page: 797, stat: Journal Article,

Sumoylation Is Important for Stability, Subcellular Localization, and Transcriptional Activity of SALL4, an Essential Stem Cell Transcription Factor
Yang, Feikun; Yao, Yixin; Jiang, Yongping; Lu, Luo; Ma, Yupo; Dai, Wei
2012 Nov;287(46):38600-38608, Journal of biological chemistry
— id: 180592, year: 2012, vol: 287, page: 38600, stat: Journal Article,

Mitotic checkpoint control and chromatin remodeling
Yao, Yixin; Dai, Wei
2012 ;17:976-983, Frontiers in biosciences
— id: 157692, year: 2012, vol: 17, page: 976, stat: Journal Article,

Shugoshins function as a guardian for chromosomal stability in nuclear division
Yao, Yixin; Dai, Wei
2012 Jul;11(14):2631-2642, Cell cycle
— id: 174077, year: 2012, vol: 11, page: 2631, stat: Journal Article,

Regulation of Pax6 by CTCF during Induction of Mouse ES Cell Differentiation
Gao, Jie; Wang, Jie; Wang, Yumei; Dai, Wei; Lu, Luo
2011 ;6(6):e20954-e20954, PLoS one
— id: 134709, year: 2011, vol: 6, page: e20954, stat: Journal Article,

Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors
Hu, Liyan; Liu, Xin; Chervona, Yana; Yang, Feikun; Tang, Moon-Shong; Darzynkiewicz, Zbigniew; Dai, Wei
2011 Jul 15;10(14):2373-2379, Cell cycle
— id: 135558, year: 2011, vol: 10, page: 2373, stat: Journal Article,

Effect of a structurally modified human granulocyte colony stimulating factor, G-CSFa, on leukopenia in mice and monkeys
Jiang, Yongping; Jiang, Wenhong; Qiu, Yuchang; Dai, Wei
2011 ;4:28-28, Journal of hematology & oncology
— id: 134915, year: 2011, vol: 4, page: 28, stat: Journal Article,

Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun
Wang, Ling; Dai, Wei; Lu, Luo
2011 May;52(6):3200-3206, Investigative ophthalmology & visual science. IOVS
— id: 135200, year: 2011, vol: 52, page: 3200, stat: Journal Article,

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells
Wang, Ling; Payton, Reid; Dai, Wei; Lu, Luo
2011 Jan 21;286(3):1951-1958, Journal of biological chemistry
— id: 132720, year: 2011, vol: 286, page: 1951, stat: Journal Article,

The function of mammalian Polo-like kinase 1 in microtubule nucleation
Xu, Dazhong; Dai, Wei
2011 Jul 12;108(28):11301-11302, Proceedings of the National Academy of Sciences of the United States of America
— id: 135188, year: 2011, vol: 108, page: 11301, stat: Journal Article,

Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E
Liu, Xue-Song; Zhao, Xu-Dong; Wang, Xiaoxing; Yao, Yi-Xin; Zhang, Liang-Liang; Shu, Run-Zhe; Ren, Wei-Hua; Huang, Ying; Huang, Lei; Gu, Ming-Min; Kuang, Ying; Wang, Long; Lu, Shun-Yuan; Chi, Jun; Fen, Jing-Sheng; Wang, Yi-Fei; Fei, Jian; Dai, Wei; Wang, Zhu-Gang
2010 Jan;1(1):26-39, Genes & cancer
— id: 138226, year: 2010, vol: 1, page: 26, stat: Journal Article,

Effect of hypoxic stress-activated Polo-like kinase 3 on corneal epithelial wound healing
Lu, Jiawei; Wang, Ling; Dai, Wei; Lu, Luo
2010 Oct;51(10):5034-5040, Investigative ophthalmology & visual science. IOVS
— id: 133854, year: 2010, vol: 51, page: 5034, stat: Journal Article,

Regulation of PTEN Stability and Activity by Plk3
Xu, Dazhong; Yao, Yixin; Jiang, Xuejun; Lu, Luo; Dai, Wei
2010 Dec 17;285(51):39935-39942, Journal of biological chemistry
— id: 115421, year: 2010, vol: 285, page: 39935, stat: Journal Article,

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1{alpha}
Xu, Dazhong; Yao, Yixin; Lu, Luo; Costa, Max; Dai, Wei
2010 Dec 10;285(50):38944-38950, Journal of biological chemistry
— id: 115272, year: 2010, vol: 285, page: 38944, stat: Journal Article,

Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function
Xu, Han-Zhang; Huang, Ying; Wu, Ying-Li; Zhao, Yong; Xiao, Wei-Lie; Lin, Qi-Shan; Sun, Han-Dong; Dai, Wei; Chen, Guo-Qiang
2010 JUL 15 ;9(14):2897-2907, Cell cycle
— id: 112194, year: 2010, vol: 9, page: 2897, stat: Journal Article,

A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae
Arita, Adriana; Zhou, Xue; Ellen, Thomas P; Liu, Xin; Bai, Jingxiang; Rooney, John P; Kurtz, Adrienne; Klein, Catherine B; Dai, Wei; Begley, Thomas J; Costa, Max
2009 ;10:524-524, BMC genomics
— id: 105506, year: 2009, vol: 10, page: 524, stat: Journal Article,

Suppression of genomic instabilities caused by chromosome mis-segregation: a perspective from studying BubR1 and Sgo1
Dai, Wei
2009 Dec;108(12):904-911, Journal of the Formosan Medical Association = Taiwan yi zhi
— id: 106098, year: 2009, vol: 108, page: 904, stat: Journal Article,

Quantitative detection of the expression of mitochondrial cytochrome c oxidase subunits mRNA in the cerebral cortex after experimental traumatic brain injury
Dai, Wei; Cheng, Hui-lin; Huang, Ren-qiang; Zhuang, Zong; Shi, Ji-Xin
2009 Jan 28;1251:287-295, Brain research
— id: 96274, year: 2009, vol: 1251, page: 287, stat: Journal Article,

Effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in the digestive system of tilapia (Oreochromis niloticus)
Dai, Wei; Du, Huahua; Fu, Linglin; Jin, Chengguan; Xu, Zirong; Liu, Huitao
2009 Feb;127(2):124-131, Biological trace element research
— id: 96277, year: 2009, vol: 127, page: 124, stat: Journal Article,

Changes in Growth Performance, Metabolic Enzyme Activities, and Content of Fe, Cu, and Zn in Liver and Kidney of Tilapia (Oreochromis niloticus) Exposed to Dietary Pb
Dai, Wei; Fu, Linglin; Du, Huahua; Jin, Chengguan; Xu, Zirong
2009 May;128(2):176-183, Biological trace element research
— id: 96276, year: 2009, vol: 128, page: 176, stat: Journal Article,

Compressive sensing DNA microarrays
Dai, Wei; Sheikh, Mona A; Milenkovic, Olgica; Baraniuk, Richard G
2009 ;:162824-162824, EURASIP journal on bioinformatics & systems biology
— id: 96272, year: 2009, vol: , page: 162824, stat: Journal Article,

Arsenic trioxide suppresses paclitaxel-induced mitotic arrest
Duan, Q; Komissarova, E; Dai, W
2009 JUN ;42(3):404-411, Cell proliferation
— id: 98846, year: 2009, vol: 42, page: 404, stat: Journal Article,

Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E
Huang, Ying; Yao, Yixin; Xu, Han-Zhang; Wang, Zhu-Gang; Lu, Luo; Dai, Wei
2009 Aug 15;8(16):2643-2649, Cell cycle
— id: 101639, year: 2009, vol: 8, page: 2643, stat: Journal Article,

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice
Rao, Chinthalapally V; Yamada, Hiroshi Y; Yao, Yixin; Dai, Wei
2009 Sep;30(9):1469-1474, Carcinogenesis
— id: 382132, year: 2009, vol: 30, page: 1469, stat: Journal Article,

Covalent modifications of histones during mitosis and meiosis
Xu, Dazhong; Bai, Jingxiang; Duan, Qing; Costa, Max; Dai, Wei
2009 Nov 15;8(22):3688-3694, Cell cycle
— id: 105250, year: 2009, vol: 8, page: 3688, stat: Journal Article,

A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity
Zhou, Xue; Arita, Adriana; Ellen, Thomas P; Liu, Xin; Bai, Jingxiang; Rooney, John P; Kurtz, Adrienne D; Klein, Catherine B; Dai, Wei; Begley, Thomas J; Costa, Max
2009 Nov;94(5):294-307, Genomics
— id: 104719, year: 2009, vol: 94, page: 294, stat: Journal Article,

Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy
Dai, Wei; Jia, Qingmei; Bortz, Eric; Shah, Sanket; Liu, Jun; Atanasov, Ivo; Li, Xudong; Taylor, Kenneth A; Sun, Ren; Zhou, Z Hong
2008 Mar;161(3):428-438, Journal of structural biology
— id: 96284, year: 2008, vol: 161, page: 428, stat: Journal Article,

Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
Dai, Wei; Teodoridis, Jens M; Graham, Janet; Zeller, Constanze; Huang, Tim H M; Yan, Pearlly; Vass, J Keith; Brown, Robert; Paul, Jim
2008 ;9:337-337, BMC bioinformatics
— id: 96278, year: 2008, vol: 9, page: 337, stat: Journal Article,

Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis
Duan, Qing; Chen, Haobin; Costa, Max; Dai, Wei
2008 Nov 28;283(48):33585-33590, Journal of biological chemistry
— id: 91974, year: 2008, vol: 283, page: 33585, stat: Journal Article,

High-level secretion of a chimeric thermostable lichenase from Bacillus subtilis by screening of site-mutated signal peptides with structural alterations
Fu, Ling-lin; Xu, Zi-rong; Shuai, Jiang-bing; Hu, Chun-xia; Dai, Wei; Li, Wei-fen
2008 Mar;56(3):287-292, Current microbiology
— id: 96283, year: 2008, vol: 56, page: 287, stat: Journal Article,

Preparation and identification of scFv and bsFv against transferrin receptor
Liu, Jing; Xiao, Daiwen; Zhou, Xiaoou; Wen, Xue; Dai, Hong; Wang, Zhihua; Shen, Xin; Dai, Wei; Yang, Daofeng; Shen, Guanxin
2008 Dec;28(6):621-625, Journal of Huazhong University of Science & Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
— id: 96273, year: 2008, vol: 28, page: 621, stat: Journal Article,

Comparison of receptor models for source apportionment of volatile organic compounds in Beijing, China
Song, Yu; Dai, Wei; Shao, Min; Liu, Ying; Lu, Sihua; Kuster, William; Goldan, Paul
2008 Nov;156(1):174-183, Environmental pollution
— id: 96282, year: 2008, vol: 156, page: 174, stat: Journal Article,

Identifying anthropogenic and natural influences on extreme pollution of respirable suspended particulates in Beijing using backward trajectory analysis
Song, Yu; Miao, Weijie; Liu, Bing; Dai, Wei; Cai, Xuhui
2008 Jun 15;154(1-3):459-468, Journal of hazardous materials
— id: 96285, year: 2008, vol: 154, page: 459, stat: Journal Article,

Activation of Polo-like kinase 3 by hypoxic stresses
Wang, Ling; Gao, Jie; Dai, Wei; Lu, Luo
2008 Sep 19;283(38):25928-25935, Journal of biological chemistry
— id: 96279, year: 2008, vol: 283, page: 25928, stat: Journal Article,

sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1
Wang, Xiaoxing; Yang, Yali; Duan, Qing; Jiang, Ning; Huang, Ying; Darzynkiewicz, Zbigniew; Dai, Wei
2008 Mar;14(3):331-341, Developmental cell
— id: 78024, year: 2008, vol: 14, page: 331, stat: Journal Article,

Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions
Yang, Yali; Bai, Jingxiang; Shen, Rulong; Brown, Sharron A N; Komissarova, Elena; Huang, Ying; Jiang, Ning; Alberts, Gregory F; Costa, Max; Lu, Luo; Winkles, Jeffrey A; Dai, Wei
2008 Jun 1;68(11):4077-4085, Cancer research
— id: 81058, year: 2008, vol: 68, page: 4077, stat: Journal Article,

Pharmacokinetic and toxicity study of intravitreal erythropoietin in rabbits
Zhang, Jing-fa; Wu, Ya-lan; Xu, Jing-ying; Ye, Wen; Zhang, Yu; Weng, Huan; Shi, Wo-dong; Xu, Guo-xu; Lu, Luo; Dai, Wei; Sinclair, Stephen H; Li, Wei-ye; Xu, Guo-tong
2008 Nov;29(11):1383-1390, Acta pharmacologica Sinica
— id: 96275, year: 2008, vol: 29, page: 1383, stat: Journal Article,

Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes
Zhang, Jingfa; Wu, Yalan; Jin, Ying; Ji, Fei; Sinclair, Stephen H; Luo, Yan; Xu, Guoxu; Lu, Luo; Dai, Wei; Yanoff, Myron; Li, Weiye; Xu, Guo-Tong
2008 Feb;49(2):732-742, Investigative ophthalmology & visual science. IOVS
— id: 96281, year: 2008, vol: 49, page: 732, stat: Journal Article,

[Evidence of bacterial biofilms in chronic rhinosinusitis]
Zhang, Zi; Li, Yun-chuan; Han, Ye-hua; Dai, Wei; Zhang, Sheng-zhong; Zhou, Bing; Zhang, Luo; Wang, De-yun; Han, De-min; Zhang, Yong-jie
2008 Nov;43(11):840-844, Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head & neck surgery
— id: 96271, year: 2008, vol: 43, page: 840, stat: Journal Article,

Intensified reaction of dilute thiophenes in nanoreactor
Zhou, Li; Wang, Shengqiang; Dai, Wei; Zhou, Yaping
2008 Mar 6;112(9):1887-1890, Journal of physical chemistry. A
— id: 96280, year: 2008, vol: 112, page: 1887, stat: Journal Article,

Study on olfactory function in GABAC receptor/channel rho1 subunit knockout mice
Chen, Yan; Zhou, Dongping; Zhou, Kun; Ren, Yiping; Dai, Wei; Xu, Ming; Lu, Luo; Lu, Zhenyu
2007 Oct 29;427(1):10-15, Neuroscience letters
— id: 76371, year: 2007, vol: 427, page: 10, stat: Journal Article,

Polo-like Kinases Inhibited by Wortmannin: LABELING SITE AND DOWNSTREAM EFFECTS
Liu, Yongsheng; Jiang, Ning; Wu, Jiangyue; Dai, Wei; Rosenblum, Jonathan S
2007 Jan 26;282(4):2505-2511, Journal of biological chemistry
— id: 70085, year: 2007, vol: 282, page: 2505, stat: Journal Article,

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents
Tanaka, Toshiki; Huang, Xuan; Halicka, H Dorota; Zhao, Hong; Traganos, Frank; Albino, Anthony P; Dai, Wei; Darzynkiewicz, Zbigniew
2007 Sep;71(9):648-661, Cytometry A
— id: 76367, year: 2007, vol: 71, page: 648, stat: Journal Article,

Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells
Wang, Ling; Dai, Wei; Lu, Luo
2007 Nov 2;282(44):32121-32127, Journal of biological chemistry
— id: 76361, year: 2007, vol: 282, page: 32121, stat: Journal Article,

Rig-I-/- mice develop colitis associated with downregulation of G alpha i2
Wang, Yi; Zhang, Hong-Xin; Sun, Yue-Ping; Liu, Zi-Xing; Liu, Xue-Song; Wang, Long; Lu, Shun-Yuan; Kong, Hui; Liu, Qiao-Ling; Li, Xi-Hua; Lu, Zhen-Yu; Chen, Sai-Juan; Chen, Zhu; Bao, Shi-San; Dai, Wei; Wang, Zhu-Gang
2007 Oct;17(10):858-868, Cell research
— id: 76360, year: 2007, vol: 17, page: 858, stat: Journal Article,

BubR1 deficiency results in enhanced activation of MEK and ERKs upon microtubule stresses
Yang, Y L; Duan, Q; Guo, T B; Wang, X X; Ruan, Q; Xu, G T; Zhang, J W; Lu, Z Y; Xu, M; Lu, L; Dai, W
2007 Jun;40(3):397-410, Cell proliferation
— id: 76364, year: 2007, vol: 40, page: 397, stat: Journal Article,

Role of c-Fos/JunD in protecting stress-induced cell death
Zhou, H; Gao, J; Lu, Z Y; Lu, L; Dai, W; Xu, M
2007 Jun;40(3):431-444, Cell proliferation
— id: 76363, year: 2007, vol: 40, page: 431, stat: Journal Article,

Aging in check
Dai, Wei; Wang, Xiaoxing
2006 Mar 15;2006(7):pe9-pe9, Science of aging knowledge environment
— id: 70086, year: 2006, vol: 2006, page: pe9, stat: Journal Article,

Grabbing Plk1 by the PBD
Dai, Wei; Wang, Xiaoxing
2006 Nov 17;24(4):489-490, Molecular cell
— id: 70160, year: 2006, vol: 24, page: 489, stat: Journal Article,

BubR1 is involved in regulation of DNA damage responses
Fang, Y; Liu, T; Wang, X; Yang, Y-M; Deng, H; Kunicki, J; Traganos, F; Darzynkiewicz, Z; Lu, L; Dai, W
2006 Jun 15;25(25):3598-3605, Oncogene
— id: 70084, year: 2006, vol: 25, page: 3598, stat: Journal Article,

Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis
Huang, Xuan; Kurose, Akira; Tanaka, Toshiki; Traganos, Frank; Dai, Wei; Darzynkiewicz, Zbigniew
2006 Apr;69(4):222-229, Cytometry A
— id: 76368, year: 2006, vol: 69, page: 222, stat: Journal Article,

Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis
Jiang, Ning; Wang, Xiaoxing; Jhanwar-Uniyal, Meena; Darzynkiewicz, Zbigniew; Dai, Wei
2006 Apr 14;281(15):10577-10582, Journal of biological chemistry
— id: 70083, year: 2006, vol: 281, page: 10577, stat: Journal Article,

Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis
Kurose, Akira; Tanaka, Toshiki; Huang, Xuan; Traganos, Frank; Dai, Wei; Darzynkiewicz, Zbigniew
2006 Apr;69(4):212-221, Cytometry A
— id: 76369, year: 2006, vol: 69, page: 212, stat: Journal Article,

ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis
Tanaka, T; Kurose, A; Huang, X; Dai, W; Darzynkiewicz, Z
2006 Feb;39(1):49-60, Cell proliferation
— id: 76366, year: 2006, vol: 39, page: 49, stat: Journal Article,

Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status
Tanaka, T; Kurose, A; Huang, X; Traganos, F; Dai, W; Darzynkiewicz, Z
2006 Aug;39(4):313-323, Cell proliferation
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Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis
Kurose, Akira; Tanaka, Toshiki; Huang, Xuan; Halicka, H Dorota; Traganos, Frank; Dai, Wei; Darzynkiewicz, Zbigniew
2005 Nov;68(1):1-9, Cytometry A
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Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
Rao, Chinthalapally V; Yang, Yang-Ming; Swamy, Malisetty V; Liu, Tongyi; Fang, Yuqiang; Mahmood, Radma; Jhanwar-Uniyal, Meena; Dai, Wei
2005 Mar 22;102(12):4365-4370, Proceedings of the National Academy of Sciences of the United States of America
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Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells
Wang, Ling; Dai, Wei; Lu, Luo
2005 Apr 21;24(18):3020-3027, Oncogene
— id: 76362, year: 2005, vol: 24, page: 3020, stat: Journal Article,

Regulation of cell cycle checkpoints by polo-like kinases
Xie, Suqing; Xie, Bin; Lee, Marietta Y; Dai, Wei
2005 Jan 10;24(2):277-286, Oncogene
— id: 70081, year: 2005, vol: 24, page: 277, stat: Journal Article,

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
Dai, Wei; Wang, Qi; Liu, Tongyi; Swamy, Malisetty; Fang, Yuqiang; Xie, Suqing; Mahmood, Radma; Yang, Yang-Ming; Xu, Ming; Rao, Chinthalapally V
2004 Jan 15;64(2):440-445, Cancer research
— id: 70074, year: 2004, vol: 64, page: 440, stat: Journal Article,

BUBR1 deficiency results in abnormal megakaryopoiesis
Wang, Qi; Liu, Tongyi; Fang, Yuqiang; Xie, Suqing; Huang, Xuan; Mahmood, Radma; Ramaswamy, Gita; Sakamoto, Kathleen M; Darzynkiewicz, Zbigniew; Xu, Ming; Dai, Wei
2004 Feb 15;103(4):1278-1285, Blood
— id: 70075, year: 2004, vol: 103, page: 1278, stat: Journal Article,

MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3
Xie, Suqing; Wang, Qi; Ruan, Qin; Liu, Tongyi; Jhanwar-Uniyal, Meena; Guan, Kunliang; Dai, Wei
2004 May 6;23(21):3822-3829, Oncogene
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