Suresh Cuddapah

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Suresh Cuddapah

Assistant Professor, Department of Environmental Medicine;Assistant Professor, Department of Biochemistry and Molecular Pharmacology
Environmental Medicine

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845/731-3635
Suresh.Cuddapah@nyumc.org

Research Summary

The eukaryotic genome is organized into higher order chromatin structures. The structure of chromatin and DNA accessibility is regulated, in part, by epigenetic features such as DNA methylation and histone modifications. The goal of our research is to understand the epigenetic regulation of chromatin structure and gene expression programs during differentiation and disease manifestation. We are particularly interested in understanding the causes for aberrant silencing of tumor suppressor genes, which contribute to malignancies. Understanding how and why certain genes are turned off will help unravel the disease mechanism. Aberration in the chromatin structure is one of the causes for mis-regulation of gene expression. Currently, we are investigating the role of transcription factors and epigenetic features of the genome that are involved in maintaining normal chromatin architecture and the anomalies that lead to aberrant gene silencing. In addition, we are also interested in understanding the alterations in epigenetic regulation due to pathogenesis, which in turn may favor disease progression.

Research Interests

Epigenetic regulation of chromatin structure and gene expression

Lineage relationship of CD8 T cell subsets is revealed by progressive changes in the epigenetic landscape
Crompton, Joseph G; Narayanan, Manikandan; Cuddapah, Suresh; Roychoudhuri, Rahul; Ji, Yun; Yang, Wenjing; Patel, Shashank J; Sukumar, Madhusudhanan; Palmer, Douglas C; Peng, Weiqun; Wang, Ena; Marincola, Francesco M; Klebanoff, Christopher A; Zhao, Keji; Tsang, John S; Gattinoni, Luca; Restifo, Nicholas P
2015-05-04; 2042-0226,Cellular & molecular immunology - id: 1556902, year: 2015 JOURNAL ARTICLE

Epigenetic dysregulation by nickel through repressive chromatin domain disruption
Jose, Cynthia C; Xu, Beisi; Jagannathan, Lakshmanan; Trac, Candi; Mallela, Ramya K; Hattori, Takamitsu; Lai, Darson; Koide, Shohei; Schones, Dustin E; Cuddapah, Suresh
2014-10-01; 0027-8424,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 1259292, year: 2014 JOURNAL ARTICLE

Insulators recruit histone methyltransferase dMes4 to regulate chromatin of flanking genes
Lhoumaud, Priscillia; Hennion, Magali; Gamot, Adrien; Cuddapah, Suresh; Queille, Sophie; Liang, Jun; Micas, Gael; Morillon, Pauline; Urbach, Serge; Bouchez, Olivier; Severac, Dany; Emberly, Eldon; Zhao, Keji; Cuvier, Olivier
2014-06-14; 0261-4189,EMBO journal - id: 1033612, year: 2014 JOURNAL ARTICLE

Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing
Liang, Jun; Lacroix, Laurent; Gamot, Adrien; Cuddapah, Suresh; Queille, Sophie; Lhoumaud, Priscillia; Lepetit, Pierre; Martin, Pascal G P; Vogelmann, Jutta; Court, Franck; Hennion, Magali; Micas, Gael; Urbach, Serge; Bouchez, Olivier; Nollmann, Marcelo; Zhao, Keji; Emberly, Eldon; Cuvier, Olivier
2014-05-13; 1097-2765,Molecular cell - id: 978582, year: 2014 Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

A novel human polycomb binding site acts as a functional polycomb response element in Drosophila
Cuddapah, Suresh; Roh, Tae-Young; Cui, Kairong; Jose, Cynthia C; Fuller, Margaret T; Zhao, Keji; Chen, Xin
2012-05-16; 1932-6203,PLoS one - id: 166805, year: 2012 Journal Article