Max Costa

Biosketch / Results /

Max Costa, Ph.D.

Professor; Chair of the Department of Enviromental Medicine
Departments of Environmental Medicine and Biochemistry and Molecular Pharmacology

Contact Info

Address
57 Old Forge Road
Floor 2nd Floor Room 208
Sterling Forest
Tuxedo, NY 10987

845-731-3515
845-351-2118
Max.Costa@nyumc.org

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Education

1976 — Dr. Costa received his Ph.D. in Pharmacology from the University of Arizona Medical School, Tuscon, AZ,, Graduate Education
1976-1977 — Dr. Costa was a Postdoctoral Fellow at the University of Arizona Medical School in Tuscon, PostDoctoral Training

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Research Summary

Water Insoluble nickel compounds vary in their carcinogenic potency due to a selectivity in the ability of the particles to be phagocytized by target cells. In the acidified phagosomes, ionic nickel is released, ultimately making its way into the nucleus. Ni ions cause an increase in DNA methylation we believe by inhibiting Fe dependent histone demethylases such as those responsible for demethylating H3K9 mono and dimethyl. This results in gene silencing. Nickel ions also inhibit the Jarid-1 family of histone demethylases which result in an increase in H3K4 trimethylation causing genes to be turned on. The dioxygenase superfamily of enzymes are the major targets for Nickel ions in cells and one member of this family are the Prolyl Hydroxylases that cause Hypoxia Inducible Factor (HIF-1 alpha) to be degraded. Inhibition of these dioxygenases by Nickel ions stabilizes HIF-1 alpha and turns on or off all HIF-1 alpha dependent genes. We have used Chip-on-chip as well as Chip-seq to map the H3K4 trimethylation changes in the genome and correlated this with RNA expression using RNA-seq. We have determined the binding constant of JHDM2A for Ni ions to be 1.7uM which is three times better than that for Fe which is bound to the active site of the enzyme. Using X-ray photo-electron spectroscopy we have determined that Ni ions bind in place of Fe to exactly the same ligands as Fe in the active site of the enzyme. Knockdown of JHDM2A as well as Nickel ion treatment results in the transformation of BEAS-2B cells to anchorage independent growth. Sprly2 and Cldn1 are down regulated by Ni inhibition of JHDM2A and these genes remain silenced after Nickel is removed and in the Nickel transformed cells. Forced expression of Sprly2 prevents Ni ion induced cell transformation and tranfection of Cldn1 reverses cell transformation induced by Nickel ions. Our goal of these studies is to prove that the inhibition of a histone demethylase JHDM2A by Ni ions is responsible for cell transformation.







Research Interests

Molecular Mechanisms of Metal Carcinogenesis

Research Keywords

Carcinogenesis, DNA methylation, Gene expression, Metals

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Arsenic epigenetically regulates SLBP which leads to aberrant polyadenylation of h3.1 mRNA that remains present outside of s phase
Brocato, J A; Chervona, Y; Jin, C; Costa, M
2014 September 2014;55:S60-S60, Environmental & molecular mutagenesis
— id: 1291782, year: 2014, vol: 55, page: S60, stat: Journal Article,

Molecular responses to hypoxia-inducible factor 1alpha and beyond
Brocato, Jason; Chervona, Yana; Costa, Max
2014 May;85(5):651-657, Molecular pharmacology
— id: 917702, year: 2014, vol: 85, page: 651, stat: Journal Article,

Arsenic induces polyadenylation of canonical histone mRNA by downregulating stem-loop binding protein gene expression
Brocato, Jason; Fang, Lei; Chervona, Yana; Chen, Danqi; Kiok, Kathrin; Sun, Hong; Tseng, Hsiang-Chi; Xu, Dazhong; Shamy, Magdy; Jin, Chunyuan; Costa, Max
2014 Sep;:1352-1353, Journal of biological chemistry
— id: 1282832, year: 2014, vol: , page: 1352, stat: Journal Article,

Particulate matter from saudi arabia induces genes involved in inflammation, metabolic syndrome and atherosclerosis
Brocato, Jason; Sun, Hong; Shamy, Magdy; Kluz, Thomas; Alghamdi, Mansour A; Khoder, Mamdouh I; Chen, Lung-Chi; Costa, Max
2014 ;77(13):751-766, Journal of toxicology & environmental health
— id: 1004972, year: 2014, vol: 77, page: 751, stat: Journal Article,

Toxicogenomic effect of nickel and beyond
Yao, Yixin; Costa, Max
2014 Sep;88(9):1645-1650, Archives of toxicology
— id: 1131842, year: 2014, vol: 88, page: 1645, stat: Journal Article,

Current technologies for assessing epigenetic marks and their utilization in the study of metal carcinogenesis
Arita, A; Costa, M
Recent trends in gene expression New York : Nova Biomedical, c2013,
— id: 1030052, year: 2013, vol: , page: 239, stat: Chapter,

Gene expression profiles in peripheral blood mononuclear cells of chinese nickel refinery workers with high exposures to nickel and control subjects
Arita, Adriana; Munoz, Alexandra; Chervona, Yana; Niu, Jingping; Qu, Qingshan; Zhao, Najuan; Ruan, Ye; Kiok, Kathrin; Kluz, Thomas; Sun, Hong; Clancy, Hailey A; Shamy, Magdy; Costa, Max
2013 Feb;22(2):261-269, Cancer epidemiology biomarkers & prevention
— id: 217832, year: 2013, vol: 22, page: 261, stat: Journal Article,

Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis
Brocato, Jason; Costa, Max
2013 Jul;43(6):493-514, Critical reviews in toxicology
— id: 438892, year: 2013, vol: 43, page: 493, stat: Journal Article,

Control of histone methylation and gene expression by oxidative stress, hypoxia, and metals
Costa, Max
2013 SEP 8;246:-, Abstracts of papers (American Chemical Society)
— id: 808312, year: 2013, vol: 246, page: , stat: Journal Article,

Structural Investigations of the Nickel-Induced Inhibition of Truncated Constructs of the JMJD2 Family of Histone Demethylases Using X-ray Absorption Spectroscopy
Giri, Nitai Charan; Passantino, Lisa; Sun, Hong; Zoroddu, Maria Antonietta; Costa, Max; Maroney, Michael J
2013 Jun;:4168-4183, Biochemistry
— id: 378592, year: 2013, vol: , page: 4168, stat: Journal Article,

Depleted uranium-induced leukemia: Epigenetic and genetic changes
Miller, A C; Clancy, H; Kluz, T; Cohen, S; Rivas, R; Miller, K; Costa, M
2013 15 Apr 2013;73(8):-, Cancer research
— id: 837782, year: 2013, vol: 73, page: , stat: Journal Article,

Nutritionally mediated oxidative stress and inflammation
Munoz, Alexandra; Costa, Max
2013 ;2013:610950-610950, Oxidative medicine & cellular longevity
— id: 425442, year: 2013, vol: 2013, page: 610950, stat: Journal Article,

Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells
Passantino, Lisa; Munoz, Alexandra B; Costa, Max
2013 Aug;:1357-1367, Metallomics : integrated biometal science
— id: 515822, year: 2013, vol: , page: 1357, stat: Journal Article,

Nickel and epigenetic gene silencing
Sun, Hong; Shamy, Magdy; Costa, Max
2013 ;4(4):583-595, Genes
— id: 881912, year: 2013, vol: 4, page: 583, stat: Journal Article,

Plasma Anti-Glycan Antibody Profiles Associated with Nickel level in Urine
Vuskovic, Marko; Barbuti, Anna-Maria; Goldsmith-Rooney, Emma; Glassman, Laura; Bovin, Nicolai; Pass, Harvey; Tchou-Wong, Kam-Meng; Chen, Meichi; Yan, Bing; Niu, Jingping; Qu, Qingshan; Costa, Max; Huflejt, Margaret
2013 Dec;6(12):302-312, Journal of proteomics & bioinformatics
— id: 899372, year: 2013, vol: 6, page: 302, stat: Journal Article,

Global Levels of Histone Modifications in Peripheral Blood Mononuclear Cells of Subjects with Exposure to Nickel
Arita A; Niu J; Qu Q; Zhao N; Ruan Y; Nadas A; Chervona Y; Wu F; Sun H; Hayes RB; Costa M
2012 Feb;120(2):198-203, Environmental health perspectives
— id: 141421, year: 2012, vol: 120, page: 198, stat: Journal Article,

The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects
Arita, Adriana; Shamy, Magdy Y; Chervona, Yana; Clancy, Harriet A; Sun, Hong; Hall, Megan N; Qu, Qingshan; Gamble, Mary V; Costa, Max
2012 Jun;26(2-3):174-178, Journal of trace elements in medicine & biology
— id: 169480, year: 2012, vol: 26, page: 174, stat: Journal Article,

Carcinogenic metals alter histone tail modifications
Chervona, Y; Costa, M
Toxicology and epigenetics Chichester, West Sussex, U.K. ; Hoboken, N.J. : John Wiley & Sons, 2012,
— id: 792152, year: 2012, vol: , page: 459, stat: Chapter,

Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium
Chervona, Yana; Arita, Adriana; Costa, Max
2012 Jul;4(7):619-627, Metallomics : integrated biometal science
— id: 171119, year: 2012, vol: 4, page: 619, stat: Journal Article,

Histone modifications and cancer: biomarkers of prognosis?
Chervona, Yana; Costa, Max
2012 ;2(5):589-597, American journal of cancer research
— id: 178065, year: 2012, vol: 2, page: 589, stat: Journal Article,

The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals
Chervona, Yana; Costa, Max
2012 Sep;53(5):1041-1047, Free radical biology & medicine
— id: 177142, year: 2012, vol: 53, page: 1041, stat: Journal Article,

Epigenomics: Pioneering a New Frontier in Cancer Research
Chervona, Yana; Costa, Max; Dai, Wei
2012 Jan;3:102605-102605, Journal of pharmacogenomics & pharmacoproteomics
— id: 1105232, year: 2012, vol: 3, page: 102605, stat: Journal Article,

Associations between Arsenic Exposure and Global Posttranslational Histone Modifications among Adults in Bangladesh
Chervona, Yana; Hall, Megan N; Arita, Adriana; Wu, Fen; Sun, Hong; Tseng, Hsiang-Chi; Ali, Eunus; Uddin, Mohammad Nasir; Liu, Xinhua; Zoroddu, Maria Antonietta; Gamble, Mary V; Costa, Max
2012 Dec;21(12):2252-2260, Cancer epidemiology biomarkers & prevention
— id: 202052, year: 2012, vol: 21, page: 2252, stat: Journal Article,

Nickel: a pervasive carcinogen
Clancy, Hailey A; Costa, Max
2012 Dec;8(12):1507-1509, Future oncology
— id: 209642, year: 2012, vol: 8, page: 1507, stat: Journal Article,

Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer
Clancy, Hailey A; Sun, Hong; Passantino, Lisa; Kluz, Thomas; Munoz, Alexandra; Zavadil, Jiri; Costa, Max
2012 Aug;4(8):784-793, Metallomics : integrated biometal science
— id: 174389, year: 2012, vol: 4, page: 784, stat: Journal Article,

Source apportionment and elemental composition of PM2.5 and PM10 in Jeddah City, Saudi Arabia
Khodeir, Mamdouh; Shamy, Magdy; Alghamdi, Mansour; Zhong, Mianhua; Sun, Hong; Costa, Max; Chen, Lung-Chi; Maciejczyk, Polina
2012 JUL;3(3):331-340, Atmospheric pollution research
— id: 185792, year: 2012, vol: 3, page: 331, stat: Journal Article,

Elucidating the mechanisms of nickel compound uptake: A review of particulate and nano-nickel endocytosis and toxicity
Munoz, Alexandra; Costa, Max
2012 Apr;260(1):1-16, Toxicology & applied pharmacology
— id: 162953, year: 2012, vol: 260, page: 1, stat: Journal Article,

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia
Sun, Hong; Shamy, Magdy; Kluz, Thomas; Munoz, Alexandra B; Zhong, Mianhua; Laulicht, Freda; Alghamdi, Mansour A; Khoder, Mamdouh I; Chen, Lung-Chi; Costa, Max
2012 Dec;265(2):147-157, Toxicology & applied pharmacology
— id: 184912, year: 2012, vol: 265, page: 147, stat: Journal Article,

Serum taurine and risk of coronary heart disease: a prospective, nested case-control study
Wojcik, OP; Koenig, KL; Zeleniuch-Jacquotte, A; Pearte, C; Costa, M; Chen, Y
2012 Feb;:169-178, European journal of nutrition
— id: 162479, year: 2012, vol: , page: 169, stat: Journal Article,

Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro
Wu F; Sun H; Kluz T; Clancy HA; Kiok K; Costa M
2012 Jan;258(2):166-175, Toxicology & applied pharmacology
— id: 141420, year: 2012, vol: 258, page: 166, stat: Journal Article,

Cyclooxygenase-2 (COX-2) Mediates Arsenite Inhibition of UVB-Induced Cellular Apoptosis in Mouse Epidermal Cl41 Cells
Zuo, Z; Ouyang, W; Li, J; Costa, M; Huang, C
2012 Jul;12(6):607-616, Current cancer drug targets
— id: 170417, year: 2012, vol: 12, page: 607, stat: Journal Article,

The control of histone methylation and gene expression by oxidative stress, hypoxia and metals
Costa M.
2011 ;51:S3-S3, Free radical biology & medicine
— id: 141793, year: 2011, vol: 51, page: S3, stat: Journal Article,

Structural comparisons of non-heme Fe enzymes
Giri N.C.; Maroney M.J.; Costa M.; Chen H.; Munck E.; Stoian S.A.
2011 ;16:S218-S218, Journal of biological inorganic chemistry. JBIC
— id: 149832, year: 2011, vol: 16, page: S218, stat: Journal Article,

X-ray Absorption Spectroscopy Structural Investigation of Early Intermediates in the Mechanism of DNA Repair by Human ABH2
Giri, Nitai Charan; Sun, Hong; Chen, Haobin; Costa, Max; Maroney, Michael J
2011 Jun 7;50(22):5067-5076, Biochemistry
— id: 134095, year: 2011, vol: 50, page: 5067, stat: Journal Article,

Liprin-alpha4 Is Required for Nickel Induced Receptor Protein Tyrosine Phosphatase-Leukocyte Antigen Related Receptor F (RPTP-LAR) Activity
Kiok, Kathrin; Sun, Hong; Clancy, Hailey; Bose, Sutapa; Kluz, Thomas; Wu, Fen; Costa, Max
2011 ;6(8):e22764-e22764, PLoS one
— id: 136524, year: 2011, vol: 6, page: e22764, stat: Journal Article,

Comparison of Gene Expression Profiles in Chromate Transformed BEAS-2B Cells
Sun, Hong; Clancy, Harriet A; Kluz, Thomas; Zavadil, Jiri; Costa, Max
2011 ;6(3):e17982-e17982, PLoS one
— id: 129325, year: 2011, vol: 6, page: e17982, stat: Journal Article,

Effects of Nickel Treatment on H3K4 Trimethylation and Gene Expression
Tchou-Wong, Kam-Meng; Kiok, Kathrin; Tang, Zuojian; Kluz, Thomas; Arita, Adriana; Smith, Phillip R; Brown, Stuart; Costa, Max
2011 ;6(3):e17728-e17728, PLoS one
— id: 130306, year: 2011, vol: 6, page: e17728, stat: Journal Article,

Nickel Ions Inhibit Histone Demethylase JMJD1A and DNA Repair Enzyme ABH2 by Replacing the Ferrous Iron in the Catalytic Centers
Chen, Haobin; Giri, Nitai Charan; Zhang, Ronghe; Yamane, Kenichi; Zhang, Yi; Maroney, Michael; Costa, Max
2010 Mar 5;285(10):7374-7383, Journal of biological chemistry
— id: 107769, year: 2010, vol: 285, page: 7374, stat: Journal Article,

Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells
Chen, Haobin; Kluz, Thomas; Zhang, Ronghe; Costa, Max
2010 Dec;31(12):2136-2144, Carcinogenesis
— id: 114823, year: 2010, vol: 31, page: 2136, stat: Journal Article,

Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis
Eckard, Jonathan; Dai, Jisen; Wu, Jing; Jian, Jinlong; Yang, Qing; Chen, Haobin; Costa, Max; Frenkel, Krystyna; Huang, Xi
2010 ;10:28-28, Cancer cell international
— id: 114147, year: 2010, vol: 10, page: 28, stat: Journal Article,

Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust
Wang, Shang; Prophete, Colette; Soukup, Joleen M; Chen, Lung-Chi; Costa, Max; Ghio, Andrew; Qu, Qingshan; Cohen, Mitchell D; Chen, Haobin
2010 Oct-Dec;7(4):298-307, Journal of immunotoxicology
— id: 138258, year: 2010, vol: 7, page: 298, stat: Journal Article,

Temporal reproducibility of taurine measurements in frozen serum of healthy postmenopausal women
Wojcik, Oktawia P; Koenig, Karen L; Zeleniuch-Jacquotte, Anne; Costa, Max; Chen, Yu
2010 Sep;104(5):629-632, British journal of nutrition
— id: 132231, year: 2010, vol: 104, page: 629, stat: Journal Article,

The potential protective effects of taurine on coronary heart disease
Wojcik, Oktawia P; Koenig, Karen L; Zeleniuch-Jacquotte, Anne; Costa, Max; Chen, Yu
2010 Jan;208(1):19-25, Atherosclerosis
— id: 101575, year: 2010, vol: 208, page: 19, stat: Journal Article,

Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma
Wu, Jennifer; Henderson, Charles; Feun, Lynn; Van Veldhuizen, Peter; Gold, Philip; Zheng, Hui; Ryan, Theresa; Blaszkowsky, Lawrence S; Chen, Haobin; Costa, Max; Rosenzweig, Barry; Nierodzik, MaryLynn; Hochster, Howard; Muggia, Franco; Abbadessa, Giovanni; Lewis, Jonathan; Zhu, Andrew X
2010 Oct;28(5):670-676, Investigational new drugs
— id: 138148, year: 2010, vol: 28, page: 670, stat: Journal Article,

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1{alpha}
Xu, Dazhong; Yao, Yixin; Lu, Luo; Costa, Max; Dai, Wei
2010 Dec 10;285(50):38944-38950, Journal of biological chemistry
— id: 115272, year: 2010, vol: 285, page: 38944, stat: Journal Article,

JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70
Zhang, Dongyun; Li, Jingxia; Costa, Max; Gao, Jimin; Huang, Chuanshu
2010 Jan 15;70(2):813-823, Cancer research
— id: 106216, year: 2010, vol: 70, page: 813, stat: Journal Article,

Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
Zhou, Xue; Sun, Hong; Chen, Haobin; Zavadil, Jiri; Kluz, Thomas; Arita, Adriana; Costa, Max
2010 May 15;70(10):4214-4221, Cancer research
— id: 110413, year: 2010, vol: 70, page: 4214, stat: Journal Article,

Nickel binding to histone H4
Zoroddu, Maria Antonietta; Peana, Massimiliano; Medici, Serenella; Casella, Luigi; Monzani, Enrico; Costa, Max
2010 Jan 21;39(3):787-793, Dalton transactions (Cambridge, England : 2003)
— id: 134096, year: 2010, vol: 39, page: 787, stat: Journal Article,

Epigenetics in metal carcinogenesis: Nickel, Arsenic, Chromium and Cadmium
Arita, Adriana; Costa, Max
2009 ;1(3):222-228, Metallomics : integrated biometal science
— id: 122687, year: 2009, vol: 1, page: 222, stat: Journal Article,

A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae
Arita, Adriana; Zhou, Xue; Ellen, Thomas P; Liu, Xin; Bai, Jingxiang; Rooney, John P; Kurtz, Adrienne; Klein, Catherine B; Dai, Wei; Begley, Thomas J; Costa, Max
2009 ;10:524-524, BMC genomics
— id: 105506, year: 2009, vol: 10, page: 524, stat: Journal Article,

Iron- and 2-oxoglutarate-dependent Dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity
Chen, Haobin; Costa, Max
2009 Feb;22(1):191-196, Biometals
— id: 96242, year: 2009, vol: 22, page: 191, stat: Journal Article,

Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis
Ellen, Thomas P; Kluz, Thomas; Harder, Mark E; Xiong, Judy; Costa, Max
2009 Jun 2;48(21):4626-4632, Biochemistry
— id: 101113, year: 2009, vol: 48, page: 4626, stat: Journal Article,

c-Myc mediates a hypoxia-induced decrease in acetylated histone H4
Li, Qin; Costa, Max
2009 Oct;91(10):1307-1310, Biochimie
— id: 102399, year: 2009, vol: 91, page: 1307, stat: Journal Article,

Alterations of histone modifications by cobalt compounds
Li, Qin; Ke, Qingdong; Costa, Max
2009 Jul;30(7):1243-1251, Carcinogenesis
— id: 100598, year: 2009, vol: 30, page: 1243, stat: Journal Article,

Mechanisms of c-myc degradation by nickel compounds and hypoxia
Li, Qin; Kluz, Thomas; Sun, Hong; Costa, Max
2009 ;4(12):e8531-e8531, PLoS one
— id: 106102, year: 2009, vol: 4, page: e8531, stat: Journal Article,

Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway
Li, Qin; Suen, Ting-Chung; Sun, Hong; Arita, Adriana; Costa, Max
2009 Mar 1;235(2):191-198, Toxicology & applied pharmacology
— id: 96241, year: 2009, vol: 235, page: 191, stat: Journal Article,

Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation
Ouyang, Weiming; Zhang, Dongyun; Li, Jingxia; Verma, Udit N; Costa, Max; Huang, Chuanshu
2009 Jan;218(1):205-214, Journal of cellular physiology
— id: 93369, year: 2009, vol: 218, page: 205, stat: Journal Article,

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium
Sun, Hong; Zhou, Xue; Chen, Haobin; Li, Qin; Costa, Max
2009 Jun 15;237(3):258-266, Toxicology & applied pharmacology
— id: 99233, year: 2009, vol: 237, page: 258, stat: Journal Article,

Covalent modifications of histones during mitosis and meiosis
Xu, Dazhong; Bai, Jingxiang; Duan, Qing; Costa, Max; Dai, Wei
2009 Nov 15;8(22):3688-3694, Cell cycle
— id: 105250, year: 2009, vol: 8, page: 3688, stat: Journal Article,

A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity
Zhou, Xue; Arita, Adriana; Ellen, Thomas P; Liu, Xin; Bai, Jingxiang; Rooney, John P; Kurtz, Adrienne D; Klein, Catherine B; Dai, Wei; Begley, Thomas J; Costa, Max
2009 Nov;94(5):294-307, Genomics
— id: 104719, year: 2009, vol: 94, page: 294, stat: Journal Article,

Effects of nickel, chromate, and arsenite on histone 3 lysine methylation
Zhou, Xue; Li, Qin; Arita, Adriana; Sun, Hong; Costa, Max
2009 Apr 1;236(1):78-84, Toxicology & applied pharmacology
— id: 97963, year: 2009, vol: 236, page: 78, stat: Journal Article,

Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis
Duan, Qing; Chen, Haobin; Costa, Max; Dai, Wei
2008 Nov 28;283(48):33585-33590, Journal of biological chemistry
— id: 91974, year: 2008, vol: 283, page: 33585, stat: Journal Article,

NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states
Ellen, Thomas P; Ke, Qingdong; Zhang, Ping; Costa, Max
2008 Jan;29(1):2-8, Carcinogenesis
— id: 76760, year: 2008, vol: 29, page: 2, stat: Journal Article,

Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity
Ke, Qingdong; Ellen, Thomas P; Costa, Max
2008 Apr 15;228(2):190-199, Toxicology & applied pharmacology
— id: 79243, year: 2008, vol: 228, page: 190, stat: Journal Article,

Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway
Ke, Qingdong; Li, Qin; Ellen, Thomas P; Sun, Hong; Costa, Max
2008 Jun;29(6):1276-1281, Carcinogenesis
— id: 80302, year: 2008, vol: 29, page: 1276, stat: Journal Article,

CrVI exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins
Qu, Qingshan; Li, Xiaomei; An, Feiyun; Jia, Guang; Liu, Lanzeng; Watanabe-Meserve, Hiroko; Koenig, Karen; Cohen, Beverly; Costa, Max; Roy, Nirmal; Zhong, Mianhua; Chen, Lung Chi; Liu, Suhua; Yan, Lei
2008 Aug;13(5):467-477, Biomarkers
— id: 93384, year: 2008, vol: 13, page: 467, stat: Journal Article,

Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions
Yang, Yali; Bai, Jingxiang; Shen, Rulong; Brown, Sharron A N; Komissarova, Elena; Huang, Ying; Jiang, Ning; Alberts, Gregory F; Costa, Max; Lu, Luo; Winkles, Jeffrey A; Dai, Wei
2008 Jun 1;68(11):4077-4085, Cancer research
— id: 81058, year: 2008, vol: 68, page: 4077, stat: Journal Article,

Arsenite alters global histone H3 methylation
Zhou, Xue; Sun, Hong; Ellen, Thomas P; Chen, Haobin; Costa, Max
2008 Sep;29(9):1831-1836, Carcinogenesis
— id: 93297, year: 2008, vol: 29, page: 1831, stat: Journal Article,

Nickel compounds
Cohen M; Klein C; Costa M
Environmental and occupational medicine Philadelphia : Wolters Kluwer/Lippincott Williams & Wilkins, 2007,
— id: 4440, year: 2007, vol: , page: ?, stat: Chapter,

Chromium compounds
Cohen MD; Costa M
Environmental and occupational medicine Philadelphia : Wolters Kluwer/Lippincott Williams & Wilkins, 2007,
— id: 4439, year: 2007, vol: , page: ?, stat: Chapter,

Molecular mechanisms of metal toxicity and carcinogenicity
Davidson T; Ke Q; Costa M
Handbook on the toxicology of metals Burlington MA : Academic Press, 2007,
— id: 4438, year: 2007, vol: , page: 79, stat: Chapter,

Selected molecular mechanisms of metal toxicity and carcinogenicity
Davidson, T; Ke, Q; Costa, M
Handbook on the Toxicology of Metals Burlington MA : Academic Press, 2007,
— id: 644392, year: 2007, vol: , page: 79, stat: Chapter,

Overview of chromium (III) toxicology
Ke Q; Costa M
Nutritional biochemisty of chromium (III) Amsterdam : Elsevier, 2007,
— id: 4441, year: 2007, vol: , page: 257, stat: Chapter,

Carcinogenicity of metal compounds
Ke Q; Costa M; Kazantzis G
Handbook on the toxicology of metals Burlington MA : Academic Press, 2007,
— id: 4436, year: 2007, vol: , page: 177, stat: Chapter,

Fluorescent tracking of nickel ions in human cultured cells
Ke, Qingdong; Davidson, Todd; Kluz, Thomas; Oller, Adriana; Costa, Max
2007 Feb 15;219(1):18-23, Toxicology & applied pharmacology
— id: 71340, year: 2007, vol: 219, page: 18, stat: Journal Article,

Nickel
Klein CB; Costa M
Handbook on the toxicology of metals Burlington MA : Academic Press, 2007,
— id: 4437, year: 2007, vol: , page: 743, stat: Chapter,

Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity
Koshiji, Minori; Kumamoto, Kensuke; Morimura, Keiichirou; Utsumi, Yasufumi; Aizawa, Michiko; Hoshino, Masami; Ohki, Shinji; Takenoshita, Seiichi; Costa, Max; Commes, Therese; Piquemal, David; Harris, Curtis-C; Tchou-Wong, Kam-Meng
2007 May 28;13(20):2803-2810, World journal of gastroenterology : WJG
— id: 73067, year: 2007, vol: 13, page: 2803, stat: Journal Article,

Chromium
Langard S; Costa M
Handbook on the toxicology of metals Burlington MA : Academic Press, 2007,
— id: 4435, year: 2007, vol: , page: 487, stat: Chapter,

Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice
Uddin, Ahmed N; Burns, Fredric J; Rossman, Toby G; Chen, Haobin; Kluz, Thomas; Costa, Max
2007 Jun 15;221(3):329-338, Toxicology & applied pharmacology
— id: 72149, year: 2007, vol: 221, page: 329, stat: Journal Article,

JNK1, but not JNK2, is required for COX-2 induction by nickel compounds
Zhang, Dongyun; Li, Jingxia; Wu, Kangjian; Ouyang, Weiming; Ding, Jin; Liu, Zheng-gang; Costa, Max; Huang, Chuanshu
2007 Apr;28(4):883-891, Carcinogenesis
— id: 68994, year: 2007, vol: 28, page: 883, stat: Journal Article,

Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter
Zhang, Ping; Tchou-Wong, Kam-Meng; Costa, Max
2007 Oct 1;67(19):9125-9133, Cancer research
— id: 74580, year: 2007, vol: 67, page: 9125, stat: Journal Article,

Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites
Arakawa, Hirohumi; Wu, Feng; Costa, Max; Rom, William; Tang, Moon-Shong
2006 Mar;27(3):639-645, Carcinogenesis
— id: 63597, year: 2006, vol: 27, page: 639, stat: Journal Article,

Molecular mechanisms of nickel toxicity and carcinogenicity
Chen H; Davidson TL; Li Q; Ke Q; Costa M
2006 ;9:391-395, Metal ions in biology & medicine = Les ions metalliques en biologie et en medicine
— id: 72796, year: 2006, vol: 9, page: 391, stat: Journal Article,

Effect of soluble nickel on cellular energy metabolism in A549 cells
Chen, Haobin; Costa, Max
2006 Oct;231(9):1474-1480, Experimental biology & medicine
— id: 68893, year: 2006, vol: 231, page: 1474, stat: Journal Article,

Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing
Chen, Haobin; Ke, Qingdong; Kluz, Thomas; Yan, Yan; Costa, Max
2006 May;26(10):3728-3737, Molecular & cellular biology
— id: 64479, year: 2006, vol: 26, page: 3728, stat: Journal Article,

Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
Chen, Haobin; Yan, Yan; Davidson, Todd L; Shinkai, Yoichi; Costa, Max
2006 Sep 15;66(18):9009-9016, Cancer research
— id: 68894, year: 2006, vol: 66, page: 9009, stat: Journal Article,

Response to comments by post and stern on article "Toxicity and carcinogenicity of chromium compounds in humans"
Costa, M; Klein, C
2006 OCT ;36(9):779-779, Critical reviews in toxicology
— id: 68959, year: 2006, vol: 36, page: 779, stat: Journal Article,

Toxicity and carcinogenicity of chromium compounds in humans
Costa, Max; Klein, Catherine B
2006 Feb;36(2):155-163, Critical reviews in toxicology
— id: 64671, year: 2006, vol: 36, page: 155, stat: Journal Article,

Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells
Davidson, Todd L; Chen, Haobin; Di Toro, Dominic M; D'Angelo, Gisela; Costa, Max
2006 Jul;45(7):479-489, Molecular carcinogenesis
— id: 67001, year: 2006, vol: 45, page: 479, stat: Journal Article,

Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway
Ding, Jin; Zhang, Xinhai; Li, Jingxia; Song, Lun; Ouyang, Weiming; Zhang, Dongyun; Xue, Caifang; Costa, Max; Melendez, J Andres; Huang, Chuanshu
2006 Dec;281(51):39022-39032, Journal of biological chemistry
— id: 156051, year: 2006, vol: 281, page: 39022, stat: Journal Article,

DMT1: which metals does it transport?
Garrick, Michael D; Singleton, Steven T; Vargas, Farida; Kuo, H-C; Zhao, Lin; Knopfel, Martin; Davidson, Todd; Costa, Max; Paradkar, Prasad; Roth, Jerome A; Garrick, Laura M
2006 ;39(1):79-85, Biological research
— id: 68997, year: 2006, vol: 39, page: 79, stat: Journal Article,

Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells
Kang, Gi Soo; Li, Qin; Chen, Haobin; Costa, Max
2006 Nov 7;610(1-2):48-55, Mutation research
— id: 68895, year: 2006, vol: 610, page: 48, stat: Journal Article,

Hypoxia-Inducible Factor-1 (HIF-1)
Ke, Qingdong; Costa, Max
2006 Nov;70(5):1469-1480, Molecular pharmacology
— id: 68996, year: 2006, vol: 70, page: 1469, stat: Journal Article,

Alterations of histone modifications and transgene silencing by nickel chloride
Ke, Qingdong; Davidson, Todd; Chen, Haobin; Kluz, Thomas; Costa, Max
2006 Jul;27(7):1481-1488, Carcinogenesis
— id: 67527, year: 2006, vol: 27, page: 1481, stat: Journal Article,

Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure
Ke, Qingdong; Li, Jingxia; Ding, Jin; Ding, Min; Wang, Liying; Liu, Bingci; Costa, Max; Huang, Chuanshu
2006 Aug;291(2):L257-L264, American journal of physiology. Lung cellular & molecular physiology
— id: 68743, year: 2006, vol: 291, page: L257, stat: Journal Article,

Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes
Li, Qin; Chen, Haobin; Huang, Xi; Costa, Max
2006 Jun 15;213(3):245-255, Toxicology & applied pharmacology
— id: 65794, year: 2006, vol: 213, page: 245, stat: Journal Article,

Altered iron homeostasis involvement in arsenite-mediated cell transformation
Wu, Jing; Eckard, Jonathan; Chen, Haobin; Costa, Max; Frenkel, Krystyna; Huang, Xi
2006 Feb 1;40(3):444-452, Free radical biology & medicine
— id: 64134, year: 2006, vol: 40, page: 444, stat: Journal Article,

Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells
Chen, Haobin; Davidson, Todd; Singleton, Steven; Garrick, Michael D; Costa, Max
2005 Aug 15;206(3):275-287, Toxicology & applied pharmacology
— id: 57867, year: 2005, vol: 206, page: 275, stat: Journal Article,

Nickel carcinogenesis: epigenetics and hypoxia signaling
Costa, Max; Davidson, Todd L; Chen, Haobin; Ke, Qingdong; Zhang, Ping; Yan, Yan; Huang, Chuanshu; Kluz, Thomas
2005 Dec 30;592(1-2):79-88, Mutation research
— id: 67383, year: 2005, vol: 592, page: 79, stat: Journal Article,

Soluble nickel interferes with cellular iron homeostasis
Davidson, Todd; Chen, Haobin; Garrick, Michael D; D'Angelo, Gisela; Costa, Max
2005 Nov;279(1-2):157-162, Molecular & cellular biochemistry
— id: 68896, year: 2005, vol: 279, page: 157, stat: Journal Article,

Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line
Ke, Qingdong; Kluz, Thomas; Costa, Max
2005 Apr;2(1):10-13, International journal of environmental research & public health
— id: 66459, year: 2005, vol: 2, page: 10, stat: Journal Article,

ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells
Li, Jingxia; Tong, Qiangsong; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2005 Nov;279(1-2):25-33, Molecular & cellular biochemistry
— id: 70870, year: 2005, vol: 279, page: 25, stat: Journal Article,

Carcinogenic effect of nickel compounds
Lu, Haitian; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2005 Nov;279(1-2):45-67, Molecular & cellular biochemistry
— id: 70872, year: 2005, vol: 279, page: 45, stat: Journal Article,

In vivo and in vitro analysis of the human tissue-type plasminogen activator gene promoter in neuroblastomal cell lines: evidence for a functional upstream kappaB element
Lux, W; Klobeck, H-G; Daniel, P B; Costa, M; Medcalf, R L; Schleuning, W-D
2005 May;3(5):1009-1017, Journal of thrombosis & haemostasis : JTH
— id: 171777, year: 2005, vol: 3, page: 1009, stat: Journal Article,

Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression
Ouyang, Weiming; Li, Jingxia; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2005 Nov;279(1-2):35-43, Molecular & cellular biochemistry
— id: 70871, year: 2005, vol: 279, page: 35, stat: Journal Article,

Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients
Caruso, Robert P; Levinson, Benjamin; Melamed, Jonathan; Wieczorek, Rosemary; Taneja, Samir; Polsky, David; Chang, Caroline; Zeleniuch-Jacquotte, Anne; Salnikow, Konstantin; Yee, Herman; Costa, Max; Osman, Iman
2004 Jan 1;10(1 Pt 1):222-227, Clinical cancer research
— id: 44771, year: 2004, vol: 10, page: 222, stat: Journal Article,

Research profile. Max Costa
Costa, Max
2004 May;6(5):57N-59N, Journal of environmental monitoring. JEM
— id: 134097, year: 2004, vol: 6, page: 57N, stat: Journal Article,

Exposure to chromium (VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice
Davidson, Todd; Kluz, Thomas; Burns, Fredric; Rossman, Toby; Zhang, Qunwei; Uddin, Ahmed; Nadas, Arthur; Costa, Max
2004 May 1;196(3):431-437, Toxicology & applied pharmacology
— id: 43216, year: 2004, vol: 196, page: 431, stat: Journal Article,

Molecular mechanisms of arsenic carcinogenesis
Huang, Chuanshu; Ke, Qingdong; Costa, Max; Shi, Xianglin
2004 Jan;255(1-2):57-66, Molecular & cellular biochemistry
— id: 42693, year: 2004, vol: 255, page: 57, stat: Journal Article,

Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells
Li, Jingxia; Chen, Haobin; Ke, Qingdong; Feng, Zhaohui; Tang, Moon-Shong; Liu, Bingci; Amin, Shantu; Costa, Max; Huang, Chuanshu
2004 Jun;40(2):104-115, Molecular carcinogenesis
— id: 42690, year: 2004, vol: 40, page: 104, stat: Journal Article,

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
Li, Jingxia; Chen, Haobin; Tang, Moon-Shong; Shi, Xianglin; Amin, Shantu; Desai, Dhimant; Costa, Max; Huang, Chuanshu
2004 Apr 12;165(1):77-86, Journal of cell biology
— id: 42691, year: 2004, vol: 165, page: 77, stat: Journal Article,

Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells
Li, Jingxia; Davidson, Gerard; Huang, Yi; Jiang, Bing-Hua; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2004 Jan 1;64(1):94-101, Cancer research
— id: 42615, year: 2004, vol: 64, page: 94, stat: Journal Article,

Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells
Li, Jingxia; Dokka, Sujatha; Wang, Liying; Shi, Xianglin; Castranova, Vincent; Yan, Yan; Costa, Max; Huang, Chuanshu
2004 Jan;255(1-2):217-225, Molecular & cellular biochemistry
— id: 42692, year: 2004, vol: 255, page: 217, stat: Journal Article,

Chromatin immunoprecipitation assays
Yan, Yan; Chen, Haobin; Costa, Max
2004 ;287(8):9-19, Methods in molecular biology
— id: 46102, year: 2004, vol: 287, page: 9, stat: Journal Article,

Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway
Zhao, Jianhua; Chen, Haobin; Davidson, Todd; Kluz, Thomas; Zhang, Qunwei; Costa, Max
2004 Jun 1;196(3):404-409, Toxicology & applied pharmacology
— id: 46203, year: 2004, vol: 196, page: 404, stat: Journal Article,

Nickel-induced down-regulation of serpin by hypoxic signaling
Zhao, Jianhua; Yan, Yan; Salnikow, Konstantin; Kluz, Thomas; Costa, Max
2004 Jan 1;194(1):60-68, Toxicology & applied pharmacology
— id: 42617, year: 2004, vol: 194, page: 60, stat: Journal Article,

Nickel(II) binding to Cap43 protein fragments
Zoroddu, M A; Peana, M; Kowalik-Jankowska, T; Kozlowski, H; Costa, M
2004 Jun;98(6):931-939, Journal of inorganic biochemistry
— id: 141435, year: 2004, vol: 98, page: 931, stat: Journal Article,

Different mechanisms in suppressing MTH expression by nickel chloride and cobalt chloride
Chen, H; Yan, Y; Kluz, T; Costa, M
2003 MAR ;72(5):1050-419, Toxicological sciences
— id: 98229, year: 2003, vol: 72, page: 1050, stat: Journal Article,

Potential hazards of hexavalent chromate in our drinking water
Costa, Max
2003 Apr 1;188(1):1-5, Toxicology & applied pharmacology
— id: 111733, year: 2003, vol: 188, page: 1, stat: Journal Article,

Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling
Costa, Max; Yan, Yan; Zhao, Daoji; Salnikow, Konstantin
2003 Apr;5(2):222-223, Journal of environmental monitoring. JEM
— id: 34642, year: 2003, vol: 5, page: 222, stat: Journal Article,

Regulation of HIF transactivation and CAP43 expression by nickel compounds through PI-3K/AKT dependent, P70S6K-independent pathway
Davidson, G; Li, J; Huang, Y; Costa, M; Huang, C
2003 MAR ;72(1):106-106, Toxicological sciences
— id: 38494, year: 2003, vol: 72, page: 106, stat: Journal Article,

Inhibition of phase I and phase II metabolic enzymes in vitro by nickel chloride
Davidson, TL; Salnikow, K; Costa, M
2003 MAR ;72(5):1058-419, Toxicological sciences
— id: 98230, year: 2003, vol: 72, page: 1058, stat: Journal Article,

Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel
Davidson, Todd; Salnikow, Konstantin; Costa, Max
2003 Dec;64(6):1485-1493, Molecular pharmacology
— id: 44774, year: 2003, vol: 64, page: 1485, stat: Journal Article,

Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells
Feng, Zhaohui; Hu, Wenwei; Rom, William N; Costa, Max; Tang, Moon-Shong
2003 Apr;24(4):771-778, Carcinogenesis
— id: 39234, year: 2003, vol: 24, page: 771, stat: Journal Article,

Inhibition and reversal of cellular transformation by the histone deacetylase inhibitor trichostatin A
Kluz, T; Zhang, Q; Salnikow, K; Costa, M
2003 MAR ;72(1):212-212, Toxicological sciences
— id: 38496, year: 2003, vol: 72, page: 212, stat: Journal Article,

The analysis of transcriptional regulation of nickel-inducible gene Cap43
Salnikow, K; Zhang, P; Costa, M
2003 MAR ;72(1):234-234, Toxicological sciences
— id: 38500, year: 2003, vol: 72, page: 234, stat: Journal Article,

GeneChip analysis of signaling pathways effected by nickel
Salnikow, Konstantin; Davidson, Todd; Kluz, Thomas; Chen, Haobin; Zhou, Daoji; Costa, Max
2003 Apr;5(2):206-209, Journal of environmental monitoring. JEM
— id: 34643, year: 2003, vol: 5, page: 206, stat: Journal Article,

The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis
Salnikow, Konstantin; Davidson, Todd; Zhang, Qunwei; Chen, Lung Chi; Su, Weichen; Costa, Max
2003 Jul 1;63(13):3524-3530, Cancer research
— id: 39165, year: 2003, vol: 63, page: 3524, stat: Journal Article,

Epigenetics and the environment
Sutherland, Jessica E; Costa, Max
2003 Mar;983:151-160, Annals of the New York Academy of Sciences
— id: 134098, year: 2003, vol: 983, page: 151, stat: Journal Article,

Analysis of chromatin structure in nickel silenced G12 Chinese hamster cells
Yan, Y; Kluz, T; Zhang, P; Chen, H; Costa, M
2003 MAR ;72(1):216-216, Toxicological sciences
— id: 38497, year: 2003, vol: 72, page: 216, stat: Journal Article,

Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure
Yan, Yan; Kluz, Thomas; Zhang, Ping; Chen, Hao-bin; Costa, Max
2003 Aug 1;190(3):272-277, Toxicology & applied pharmacology
— id: 39116, year: 2003, vol: 190, page: 272, stat: Journal Article,

Downregulation of a zinc finger protein-ZFP61 by Ni in mouse cells in vitro and in vivo
Zhang, P; Costa, M
2003 MAR ;72(1):234-234, Toxicological sciences
— id: 38501, year: 2003, vol: 72, page: 234, stat: Journal Article,

Chromate induces the HGPRT gene silencing by DNA methylation: A new epigenetic mechanism for chromate carcinogenesis
Zhang, Q; Kluz, T; Salnikow, K; Costa, M
2003 MAR ;72(1):234-234, Toxicological sciences
— id: 38499, year: 2003, vol: 72, page: 234, stat: Journal Article,

Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A
Zhang, Qunwei; Salnikow, Konstantin; Kluz, Thomas; Chen, Lung Chi; Su, Wei Cheng; Costa, Max
2003 Nov 1;192(3):201-211, Toxicology & applied pharmacology
— id: 44775, year: 2003, vol: 192, page: 201, stat: Journal Article,

Down regulation of a serine proteinase inhibitor by Ni and Co is dependent on hypoxia inducible factor signalling
Zhao, J; Yan, Y; Costa, M
2003 MAR ;72(1):234-234, Toxicological sciences
— id: 38502, year: 2003, vol: 72, page: 234, stat: Journal Article,

Molecular mechanisms of nickel carcinogenesis
Cangul, H; Broday, L; Salnikow, K; Sutherland, J; Peng, W; Zhang, Q; Poltaratsky, V; Yee, H; Zoroddu, M A; Costa, M
2002 Feb 28;127(1-3):69-75, Toxicology letters
— id: 34648, year: 2002, vol: 127, page: 69, stat: Journal Article,

Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis
Cangul, H; Salnikow, K; Yee, H; Zagzag, D; Commes, T; Costa, M
2002 ;18(2):87-96, Cell biology & toxicology
— id: 34649, year: 2002, vol: 18, page: 87, stat: Journal Article,

Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells
Cangul, Hakan; Salnikow, Konstantin; Yee, Herman; Zagzag, David; Commes, Therese; Costa, Max
2002 Oct;110 Suppl 5(2):783-788, Environmental health perspectives
— id: 34644, year: 2002, vol: 110 Suppl 5, page: 783, stat: Journal Article,

Use of XAS for the elucidation of metal structure and function: applications to nickel biochemistry, molecular toxicology, and carcinogenesis
Carrington, Paul E; Al-Mjeni, Faizah; Zoroddu, Maria A; Costa, Max; Maroney, Michael J
2002 Oct;110 Suppl 5:705-708, Environmental health perspectives
— id: 134099, year: 2002, vol: 110 Suppl 5, page: 705, stat: Journal Article,

Molecular responses of mammalian cells to nickel and chromate exposure
Costa M; Salnikow K; Sutherland JE; Klutz T; Peng W; Tang M-S
Biomarkers of environmentally associated disease : technologies, concepts, and perspectives Boca Raton FL : Lewis Publishers, 2002,
— id: 4434, year: 2002, vol: , page: 261, stat: Chapter,

Preface - Third International Meeting on the Molecular Mechanisms of Metal Toxicity and Carcinogenicity
Costa, M; Zoroddu, MA; Suk, WA; Thompson, C; Rossman, T
2002 OCT ;110(3):687-687, Environmental health perspectives
— id: 33048, year: 2002, vol: 110, page: 687, stat: Journal Article,

Molecular mechanisms of nickel carcinogenesis
Costa, Max
2002 Jun;383(6):961-967, Biological chemistry
— id: 39406, year: 2002, vol: 383, page: 961, stat: Journal Article,

The role of oxidative stress in nickel and chromate genotoxicity
Costa, Max; Salnikow, Konstantin; Sutherland, Jessica E; Broday, Limor; Peng, Wu; Zhang, Qunwei; Kluz, Thomas
2002 May-Jun;234-235(1-2):265-275, Molecular & cellular biochemistry
— id: 34647, year: 2002, vol: 234-235, page: 265, stat: Journal Article,

Differential role of hydrogen peroxide in UV-induced signal transduction
Ding, Min; Li, Jingxia; Leonard, Stephen S; Shi, Xianglin; Costa, Max; Castranova, Vincent; Vallyathan, Val; Huang, Chuanshu
2002 May-Jun;234-235(1-2):81-90, Molecular & cellular biochemistry
— id: 38402, year: 2002, vol: 234-235, page: 81, stat: Journal Article,

Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C
Huang, Chuanshu; Li, Jingxia; Ke, Qingdong; Leonard, Stephen S; Jiang, Bing-Hua; Zhong, Xiao-Song; Costa, Max; Castranova, Vincent; Shi, Xianglin
2002 Oct 15;62(20):5689-5697, Cancer research
— id: 38401, year: 2002, vol: 62, page: 5689, stat: Journal Article,

Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds
Huang, Yi; Davidson, Gerard; Li, Jingxia; Yan, Yan; Chen, Fei; Costa, Max; Chen, Lung Chi; Huang, Chuanshu
2002 Oct;110 Suppl 5(4):835-839, Environmental health perspectives
— id: 38400, year: 2002, vol: 110 Suppl 5, page: 835, stat: Journal Article,

The role of hypoxia-inducible signaling pathway in nickel carcinogenesis
Salnikow, Konstantin; Davidson, Todd; Costa, Max
2002 Oct;110 Suppl 5(2):831-834, Environmental health perspectives
— id: 34645, year: 2002, vol: 110 Suppl 5, page: 831, stat: Journal Article,

The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia
Salnikow, Konstantin; Kluz, Thomas; Costa, Max; Piquemal, David; Demidenko, Zoya N; Xie, Keping; Blagosklonny, Mikhail V
2002 Mar;22(6):1734-1741, Molecular & cellular biology
— id: 26987, year: 2002, vol: 22, page: 1734, stat: Journal Article,

DNA methylation and gene silencing
Sutherland JE; Costa M
Comprehensive toxicology : volume 14, Cellular and molecular toxicology New York : Elsevier, 2002,
— id: 4432, year: 2002, vol: , page: 299, stat: Chapter,

Nickel
Sutherland JE; Costa M
Heavy metals in the environment New York : Dekker, 2002,
— id: 4433, year: 2002, vol: , page: ?, stat: Chapter,

Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals
Zhang, Qunwei; Kluz, Thomas; Salnikow, Konstantin; Costa, Max
2002 Apr;86(1):11-22, Biological trace element research
— id: 34650, year: 2002, vol: 86, page: 11, stat: Journal Article,

Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR (vol 84, pg 47, 2001)
Zoroddu, MA; Kowalik-Jankowska, T; Kozlowski, H; Salnikow, K; Costa, M
2002 AUG 15 ;91(2):421-421, Journal of inorganic biochemistry
— id: 55290, year: 2002, vol: 91, page: 421, stat: Journal Article,

The binding of Ni(II) and Cu(II) with the N-terminal tail of the histone H4
Zoroddu, MA; Peana, M; Kowalik-Jankowska, T; Kozlowski, H; Costa, M
2002 Jan 20;18(3):458-465, Journal of the Chemical Society. Dalton transactions
— id: 28193, year: 2002, vol: 18, page: 458, stat: Journal Article,

Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4
Zoroddu, Maria Antonietta; Schinocca, Laura; Kowalik-Jankowska, Teresa; Kozlowski, Henryk; Salnikow, Konstantin; Costa, Max
2002 Oct;110 Suppl 5(2):719-723, Environmental health perspectives
— id: 34646, year: 2002, vol: 110 Suppl 5, page: 719, stat: Journal Article,

Detecting epigenetic changes: DNA methylation
Broday, L; Costa, M
2001 May;Chapter 3:Unit3.6-Unit3.6 Unit3.6, Current protocols in toxicology
— id: 248762, year: 2001, vol: Chapter 3, page: Unit3.6, stat: Journal Article,

Molecular biology of nickel carcinogenesis
Costa M; Sutherland JE; Peng W; Salnikow K; Broday L; Kluz T
2001 Jun;222(1-2):205-211, Molecular & cellular biochemistry
— id: 26988, year: 2001, vol: 222, page: 205, stat: Journal Article,

Cell transformation assays
Costa, M; Sutherland, J E
2001 May;Chapter 3:Unit3.4-Unit3.4 Unit3.4, Current protocols in toxicology
— id: 248742, year: 2001, vol: Chapter 3, page: Unit3.4, stat: Journal Article,

Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide
Huang C; Li J; Costa M; Zhang Z; Leonard SS; Castranova V; Vallyathan V; Ju G; Shi X
2001 Nov 15;61(22):8051-8057, Cancer research
— id: 26560, year: 2001, vol: 61, page: 8051, stat: Journal Article,

Transactivation of RARE and GRE in the cellular response to arsenic
Huang C; Li J; Ding M; Costa M; Castranova V; Vallyathan V; Ju G; Shi X
2001 Jun;222(1-2):119-125, Molecular & cellular biochemistry
— id: 38405, year: 2001, vol: 222, page: 119, stat: Journal Article,

Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells
Huang C; Li J; Ding M; Wang L; Shi X; Castranova V; Vallyathan V; Ju G; Costa M
2001 Jun;222(1-2):29-34, Molecular & cellular biochemistry
— id: 38403, year: 2001, vol: 222, page: 29, stat: Journal Article,

Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo
Huang C; Zhang Q; Li J; Shi X; Castranova V; Ju G; Costa M; Dong Z
2001 Jun;222(1-2):141-147, Molecular & cellular biochemistry
— id: 38404, year: 2001, vol: 222, page: 141, stat: Journal Article,

Mutagenesis assays in Mammalian cells
Klein, C B; Broday, L; Costa, M
2001 May;Chapter 3:Unit3.3-Unit3.3, Current protocols in toxicology
— id: 113815, year: 2001, vol: Chapter 3, page: Unit3.3, stat: Journal Article,

The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells
Sutherland JE; Peng W; Zhang Q; Costa M
2001 Aug 8;479(1-2):225-233, Mutation research
— id: 26632, year: 2001, vol: 479, page: 225, stat: Journal Article,

Assays for DNA damage
Sutherland, J E; Costa, M
2001 May;Chapter 3:Unit3.5-Unit3.5 Unit3.5, Current protocols in toxicology
— id: 248752, year: 2001, vol: Chapter 3, page: Unit3.5, stat: Journal Article,

Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR
Zoroddu MA; Kowalik-Jankowska T; Kozlowski H; Salnikow K; Costa M
2001 Mar;84(1-2):47-54, Journal of inorganic biochemistry
— id: 34652, year: 2001, vol: 84, page: 47, stat: Journal Article,

Nickel compounds are novel inhibitors of histone H4 acetylation
Broday L; Peng W; Kuo MH; Salnikow K; Zoroddu M; Costa M
2000 Jan 15;60(2):238-241, Cancer research
— id: 11839, year: 2000, vol: 60, page: 238, stat: Journal Article,

Chromium
Cohen M; Costa M
Environmental toxicants : human exposures and their health effects New York : Wiley, 2000,
— id: 4430, year: 2000, vol: , page: 173, stat: Chapter,

Chromium
Costa M
Molecular biology and toxicology of metals New York : Taylor & Francis, 2000,
— id: 4429, year: 2000, vol: , page: 113, stat: Chapter,

Trace elements: alumninum, arsenic, cadmium, and nickel
Costa M
Environmental toxicants : human exposures and their health effects New York : Wiley, 2000,
— id: 4431, year: 2000, vol: , page: 811, stat: Chapter,

Transcriptional inactivation of genes by nickel compounds involves inhibition of histone H$ acetylation
Costa M; Salnikow K; Broday L; Peng W; Sutherland JE; Zoroddu M
2000 ;6:95-97, Metal ions in biology & medicine = Les ions metalliques en biologie et en medicine
— id: 72793, year: 2000, vol: 6, page: 95, stat: Journal Article,

Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis
Huang C; Zhang Z; Ding M; Li J; Ye J; Leonard SS; Shen HM; Butterworth L; Lu Y; Costa M; Rojanasakul Y; Castranova V; Vallyathan V; Shi X
2000 Oct 20;275(42):32516-32522, Journal of biological chemistry
— id: 34185, year: 2000, vol: 275, page: 32516, stat: Journal Article,

Carcinogenic nickel induces genes involved with hypoxic stress
Salnikow K; Blagosklonny MV; Ryan H; Johnson R; Costa M
2000 Jan 1;60(1):38-41, Cancer research
— id: 10355, year: 2000, vol: 60, page: 38, stat: Journal Article,

Epigenetic mechanisms of nickel carcinogenesis
Salnikow K; Costa M
2000 ;19(3):307-318, Journal of environmental pathology, toxicology & oncology
— id: 10343, year: 2000, vol: 19, page: 307, stat: Journal Article,

Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
Salnikow K; Costa M; Figg WD; Blagosklonny MV
2000 Oct 15;60(20):5630-5634, Cancer research
— id: 15999, year: 2000, vol: 60, page: 5630, stat: Journal Article,

Identification of signaling pathways affected by nickel compounds
Salnikow K; Costa M; Klutz T; Zoroddu M
2000 ;6:98-100, Metal ions in biology & medicine = Les ions metalliques en biologie et en medicine
— id: 72794, year: 2000, vol: 6, page: 98, stat: Journal Article,

Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
Salnikow K; Su W; Blagosklonny MV; Costa M
2000 Jul 1;60(13):3375-3378, Cancer research
— id: 10345, year: 2000, vol: 60, page: 3375, stat: Journal Article,

Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium
Sutherland JE; Zhitkovich A; Kluz T; Costa M
2000 Apr;74(1):41-53, Biological trace element research
— id: 39531, year: 2000, vol: 74, page: 41, stat: Journal Article,

Interaction of Ni(II) and Cu(II) with metal binding sequences of histone H4
Zoroddu M; Kowalik-Jankowska T; Kozlowski H; Salnikow K; Broady L; Costa M
2000 ;6:101-103, Metal ions in biology & medicine = Les ions metalliques en biologie et en medicine
— id: 72795, year: 2000, vol: 6, page: 101, stat: Journal Article,

Interaction of Ni(II) and Cu(II) with a metal binding sequence of histone H4: AKRHRK, a model of the H4 tail
Zoroddu MA; Kowalik-Jankowska T; Kozlowski H; Molinari H; Salnikow K; Broday L; Costa M
2000 Jul 3;1475(2):163-168, Biochimica & biophysica acta
— id: 16000, year: 2000, vol: 1475, page: 163, stat: Journal Article,

Nickel enhances telomeric silencing in Saccharomyces cerevisiae
Broday L; Cai J; Costa M
1999 Apr 6;440(2):121-130, Mutation research
— id: 6096, year: 1999, vol: 440, page: 121, stat: Journal Article,

5-azacytidine induces transgene silencing by DNA methylation in Chinese hamster cells
Broday L; Lee YW; Costa M
1999 Apr;19(4):3198-3204, Molecular & cellular biology
— id: 6060, year: 1999, vol: 19, page: 3198, stat: Journal Article,

Nickel carcinogenesis, mutation, epigenetics, or selection
Costa, M; Klein, CB
1999 SEP ;107(9):A438-A439, Environmental health perspectives
— id: 53956, year: 1999, vol: 107, page: A438, stat: Journal Article,

Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors
Salnikow K; An WG; Melillo G; Blagosklonny MV; Costa M
1999 Sep;20(9):1819-1823, Carcinogenesis
— id: 6193, year: 1999, vol: 20, page: 1819, stat: Journal Article,

Role of Ca(2+) in the regulation of nickel-inducible Cap43 gene expression
Salnikow K; Kluz T; Costa M
1999 Oct 15;160(2):127-132, Toxicology & applied pharmacology
— id: 6223, year: 1999, vol: 160, page: 127, stat: Journal Article,

Chromium compounds
Cohen MD; Costa M
Environmental and occupational medicine Philadelphia : Lippincott-Raven, 1998,
— id: 4427, year: 1998, vol: , page: 1045, stat: Chapter,

Carcinogenic metals
Costa M
1998 ;81 ( Pt 4):329-339, Science progress
— id: 6069, year: 1998, vol: 81 ( Pt 4), page: 329, stat: Journal Article,

Molecular biology of nickel carcinogenesis
Costa, M
1998 JUN ;361(4):381-385, Fresenius journal of analytical chemistry
— id: 53384, year: 1998, vol: 361, page: 381, stat: Journal Article,

Effects of nickel on DNA methyltransferase activity and genomic DNA methylation levels
Lee YW; Broday L; Costa M
1998 Jul 31;415(3):213-218, Mutation research
— id: 7646, year: 1998, vol: 415, page: 213, stat: Journal Article,

Nickel toxicity and nickel carcinogenesis
Snow ET; Costa M
Environmental and occupational medicine Philadelphia : Lippincott-Raven, 1998,
— id: 4428, year: 1998, vol: , page: 1057, stat: Chapter,

Cr(III)-mediated crosslinks of glutathione or amino acids to the DNA phosphate backbone are mutagenic in human cells
Voitkun V; Zhitkovich A; Costa M
1998 Apr 15;26(8):2024-2030, Nucleic acids research
— id: 8085, year: 1998, vol: 26, page: 2024, stat: Journal Article,

Utilization of DNA-protein cross-links as a biomarker of chromium exposure
Zhitkovich A; Voitkun V; Kluz T; Costa M
1998 Aug;106 Suppl 4:969-974, Environmental health perspectives
— id: 7869, year: 1998, vol: 106 Suppl 4, page: 969, stat: Journal Article,

Biologic markers
Zhitkovitch A; Costa M
Environmental and occupational medicine Philadelphia : Lippincott-Raven, 1998,
— id: 4426, year: 1998, vol: , page: 177, stat: Chapter,

Cap43, a novel gene specifically induced by Ni2+ compounds
Zhou D; Salnikow K; Costa M
1998 May 15;58(10):2182-2189, Cancer research
— id: 7870, year: 1998, vol: 58, page: 2182, stat: Journal Article,

Chromatin condensation and DNA methylation during nickel carcinogenesis
Costa M
1997 ;5:359-366, Metal ions in biology & medicine = Les ions metalliques en biologie et en medicine
— id: 72782, year: 1997, vol: 5, page: 359, stat: Journal Article,

Epigenetic mechanisms of nickel carcinogenesis
Costa M
Trace elements in man and animals -- 9 Ottawa : NRC Research Press, 1997,
— id: 4424, year: 1997, vol: , page: 534, stat: Chapter,

Nonmutagenic mechanisms of nickel carcinogenesis : inactivation of critical genes by nickel-induced DNA methylation and chromatin condensation
Costa M
Correlations between in vitro and in vivo investigations in inhalation toxicology Washington DC : ILSI Press, 1997,
— id: 4423, year: 1997, vol: , page: 359, stat: Chapter,

Toxicity and carcinogenicity of Cr(VI) in animal models and humans
Costa M
1997 Sep;27(5):431-442, Critical reviews in toxicology
— id: 10361, year: 1997, vol: 27, page: 431, stat: Journal Article,

DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells
Costa M; Zhitkovich A; Harris M; Paustenbach D; Gargas M
1997 Apr 11;50(5):433-449, Journal of toxicology & environmental health
— id: 12327, year: 1997, vol: 50, page: 433, stat: Journal Article,

Carcinogenic inorganic chemicals
Farrell RP; Costa M
Comprehensive toxicology New York : Pergamon Press, 1997,
— id: 4425, year: 1997, vol: 12, page: 225, stat: Chapter,

DNA methylation and gene expression: introduction and overview
Klein CB; Costa M
1997 Apr;386(2):103-105, Mutation research
— id: 12337, year: 1997, vol: 386, page: 103, stat: Journal Article,

DNA methylation, heterochromatin and epigenetic carcinogens
Klein CB; Costa M
1997 Apr;386(2):163-180, Mutation research
— id: 8210, year: 1997, vol: 386, page: 163, stat: Journal Article,

Carcinogenicity assessment of selected nickel compounds
Oller, A R; Costa, M; Oberdorster, G
1997 Mar;143(1):152-166, Toxicology & applied pharmacology
— id: 141436, year: 1997, vol: 143, page: 152, stat: Journal Article,

Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression
Salnikow K; Wang S; Costa M
1997 Nov 15;57(22):5060-5066, Cancer research
— id: 12220, year: 1997, vol: 57, page: 5060, stat: Journal Article,

Ternary DNA adducts formed by carcinogenic Cr compounds: In vitro formation and mutagenic potential
Zhitkovich A; Voitkun V; Costa M
1997 ;38:A271-A271, Proceedings of the annual meeting of the American Association for Cancer Research
— id: 6030, year: 1997, vol: 38, page: A271, stat: Journal Article,

Carcinogenicity and genotoxicity of lead, beryllium, and other metals
Cohen MD; Bowser DH; Costa M
Toxicology of metals Boca Raton FL : Lewis Publishers, 1996,
— id: 4422, year: 1996, vol: , page: 253, stat: Chapter,

Mechanisms of nickel genotoxicity and carcinogenicity
Costa M
Toxicology of metals Boca Raton FL : Lewis Publishers, 1996,
— id: 4421, year: 1996, vol: , page: 245, stat: Chapter,

Overview : an introduction to metal toxicity and carcinogenicity of metals
Costa M
Toxicology of metals Boca Raton FL : Lewis Publishers, 1996,
— id: 4420, year: 1996, vol: , page: 203, stat: Chapter,

Interlaboratory validation of a new assay for DNA-protein crosslinks
Costa M; Zhitkovich A; Gargas M; Paustenbach D; Finley B; Kuykendall J; Billings R; Carlson TJ; Wetterhahn K; Xu J; Patierno S; Bogdanffy M
1996 Jul 10;369(1-2):13-21, Mutation research
— id: 10371, year: 1996, vol: 369, page: 13, stat: Journal Article,

Monitoring human lymphocytic DNA-protein cross-links as biomarkers of biologically active doses of chromate
Costa M; Zhitkovich A; Toniolo P; Taioli E; Popov T; Lukanova A
1996 Oct;104 Suppl 5:917-919, Environmental health perspectives
— id: 12521, year: 1996, vol: 104 Suppl 5, page: 917, stat: Journal Article,

Peroxidase deficiency of nickel-transformed hamster cells correlates with their increased resistance to cytotoxicity of peroxides
Dowjat WK; Huang X; Cosentino S; Costa M
1996 Apr;9(2):151-156, Biometals
— id: 10372, year: 1996, vol: 9, page: 151, stat: Journal Article,

Mutagenicity of cobalt and reactive oxygen producers
Kitahara J; Yamanaka K; Kato K; Lee YW; Klein CB; Costa M
1996 Oct 1;370(3-4):133-140, Mutation research
— id: 10369, year: 1996, vol: 370, page: 133, stat: Journal Article,

Occupational exposure to Cr(VI): comparison between chromium levels in lymphocytes, erythrocytes, and urine
Lukanova A; Toniolo P; Zhitkovich A; Nikolova V; Panev T; Popov T; Taioli E; Costa M
1996 ;69(1):39-44, International archives of occupational & environmental health
— id: 10374, year: 1996, vol: 69, page: 39, stat: Journal Article,

DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients
Taioli, E; Zhitkovich, A; Toniolo, P; Bernstein, J; Blum, R; Costa, M
1996 MAY-JUN ;3(3):439-441, Oncology reports
— id: 52979, year: 1996, vol: 3, page: 439, stat: Journal Article,

Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro: importance of trivalent chromium and the phosphate group
Zhitkovich A; Voitkun V; Costa M
1996 Jun 4;35(22):7275-7282, Biochemistry
— id: 7063, year: 1996, vol: 35, page: 7275, stat: Journal Article,

DNA-protein crosslinks in peripheral lymphocytes of individuals exposed to hexavalent chromium compounds
Zhitkovich, A; Lukanova, A; Popov, T; Taioli, E; Cohen, H; Costa, M; Toniolo, P
1996 APR-JUN ;1(2):86-93, Biomarkers
— id: 52703, year: 1996, vol: 1, page: 86, stat: Journal Article,

The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding
Bellosta P; Costa M; Lin DA; Basilico C
1995 Feb;15(2):614-625, Molecular & cellular biology
— id: 8207, year: 1995, vol: 15, page: 614, stat: Journal Article,

Chemical mechanisms of metal carcinogenesis
Costa M
Handbook of metal-ligand interactions in biological fluids : bioinorganic chemistry New York : Dekker, 1995,
— id: 4418, year: 1995, vol: , page: 838, stat: Chapter,

Diverse aspects of metal carcinogenesis
Costa M
Handbook of metal-ligand interactions in biological fluids : bioinorganic chemistry New York : Dekker, 1995,
— id: 4419, year: 1995, vol: , page: 1003, stat: Chapter,

Inactivation of critical cancer-related genes by nickel-induced DNA hypermethylation and increased chromatin condensation
Costa M
Genetic response to metals New York : Dekker, 1995,
— id: 4417, year: 1995, vol: , page: 53, stat: Chapter,

Model for the epigenetic mechanism of action of nongenotoxic carcinogens
Costa M
1995 Mar;61(3 Suppl):666S-669S, American journal of clinical nutrition
— id: 6596, year: 1995, vol: 61, page: 666S, stat: Journal Article,

MOLECULAR RESPONSE TO NICKEL - INHERITED EFFECTS ON TRANSCRIPTION
COSTA, M
1995 MAR 10 ;14(1-6):242-242, Journal of cellular biochemistry
— id: 86744, year: 1995, vol: 14, page: 242, stat: Journal Article,

NICKEL CARCINOGENESIS - INACTIVATION OF SENESCENCE AND OTHER CANCER-RELATED GENES BY ENHANCED HETEROCHROMATIN CONDENSATION AND DNA HYPERMETHYLATION
COSTA, M
1995 JAN 5 ;336(3):185-185, Journal of cellular biochemistry
— id: 87350, year: 1995, vol: 336, page: 185, stat: Journal Article,

INACTIVATION OF RETINOBLASTOMA PROTEIN ASSOCIATED WITH NICKEL-INDUCED TRANSFORMATION OF HUMAN-CELLS
DOWJAT, WK; LIN, X; COSTA, M
1995 JAN 5 ;336(3):195-195, Journal of cellular biochemistry
— id: 87352, year: 1995, vol: 336, page: 195, stat: Journal Article,

Unlike chromium(III) alone, low concentrations of amino acid-chromium(III)-DNA-crosslinks act as strong blocks to DNA replication
Gao M; Snow ET; Singh J; Zhitkovich A; Costa M
1995 ;25 (Suppl. 25):17-17, Environmental & molecular mutagenesis
— id: 6033, year: 1995, vol: 25 (Suppl. 25), page: 17, stat: Journal Article,

Heterochromatic proteins specifically enhance nickel-induced 8-oxo-dG formation
Huang X; Kitahara J; Zhitkovich A; Dowjat K; Costa M
1995 Aug;16(8):1753-1759, Carcinogenesis
— id: 6833, year: 1995, vol: 16, page: 1753, stat: Journal Article,

Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens
Lee YW; Klein CB; Kargacin B; Salnikow K; Kitahara J; Dowjat K; Zhitkovich A; Christie NT; Costa M
1995 May;15(5):2547-2557, Molecular & cellular biology
— id: 6675, year: 1995, vol: 15, page: 2547, stat: Journal Article,

THE LOW-LEVELS OF SOME TRANSCRIPTION FACTORS BINDING IN NICKEL RESISTANT CELLS CORRELATES WITH SILENCING OF THROMBOSPONDIN EXPRESSION
SALNIKOW, K; GAO, M; WANG, S; COSTA, M
1995 JAN 5 ;336(3):190-190, Journal of cellular biochemistry
— id: 87351, year: 1995, vol: 336, page: 190, stat: Journal Article,

Increased DNA-protein crosslinks in lymphocytes of residents living in chromium-contaminated areas
Taioli E; Zhitkovich A; Kinney P; Udasin I; Toniolo P; Costa M
1995 Dec;50(3):175-180, Biological trace element research
— id: 10377, year: 1995, vol: 50, page: 175, stat: Journal Article,

NORMAL VALUES OF DNA-PROTEIN CROSS-LINKS IN MONONUCLEAR BLOOD-CELLS OF A POPULATION OF HEALTHY CONTROLS
TAIOLI, E; ZHITKOVICH, A; TONIOLO, P; COSTA, M
1995 MAR-APR ;8(2):76-79, Cancer Journal = Journal du cancer = Diario del cancer
— id: 87362, year: 1995, vol: 8, page: 76, stat: Journal Article,

Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate
Zhitkovich A; Voitkun V; Costa M
1995 Apr;16(4):907-913, Carcinogenesis
— id: 6795, year: 1995, vol: 16, page: 907, stat: Journal Article,

GLUTATHIONE AND FREE AMINO-ACIDS FORM STABLE ADDUCTS WITH DNA FOLLOWING EXPOSURE OF CHO CELLS TO CHROMATE
ZHITKOVICH, A; VOITKUN, V; COSTA, M
1995 JAN 5 ;336(3):198-198, Journal of cellular biochemistry
— id: 87354, year: 1995, vol: 336, page: 198, stat: Journal Article,

The role of oxygen radicals in the nickel-induced toxicity and carcinogenicity
Costa M
Frontiers of reactive oxygen species in biology and medicine Amsterdam : Excerpta Medica, 1994,
— id: 4416, year: 1994, vol: , page: 539, stat: Chapter,

Molecular mechanisms of nickel carcinogenesis
Costa M; Salnikow K; Cosentino S; Klein CB; Huang X; Zhuang Z
1994 Sep;102 Suppl 3:127-130, Environmental health perspectives
— id: 8073, year: 1994, vol: 102 Suppl 3, page: 127, stat: Journal Article,

Molecular mechanisms of nickel carcinogenesis
Costa M; Zhuang Z; Huang X; Cosentino S; Klein CB; Salnikow K
1994 Jun 6;148(2-3):191-199, Science of the total environment
— id: 10380, year: 1994, vol: 148, page: 191, stat: Journal Article,

MOLECULAR MECHANISMS OF NICKEL CARCINOGENESIS - INHERITED EFFECTS ON TRANSCRIPTION
COSTA, M
1994 MAR 13 ;207(11):421-INOR, Abstracts of papers (American Chemical Society)
— id: 52570, year: 1994, vol: 207, page: 421, stat: Journal Article,

2ND INTERNATIONAL MEETING ON MOLECULAR MECHANISMS OF METAL TOXICITY AND CARCINOGENICITY - JANUARY 10-17, 1993 MADONNA-DI-CAMPIGLIO, ITALY - PREFACE
COSTA, M; CANTONI, O; KLEIN, C; ROSSMAN, T; SNOW, E; SUK, W
1994 SEP ;102(1):2-2, Environmental health perspectives
— id: 52335, year: 1994, vol: 102, page: 2, stat: Journal Article,

ALTERATION IN THE PHOSPHORYLATION OF THE RB PROTEIN IN NICKEL-TRANSFORMED HUMAN-CELLS
COSTA, M; DOWJAT, WK; LIN, XL
1994 FEB 13 ;15(3):194-194, Journal of cellular biochemistry
— id: 52509, year: 1994, vol: 15, page: 194, stat: Journal Article,

Second International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogenicity : January 10-17, 1993, Madonna di Campiglio, Italy
Costa, Max
Research Triangle Park, NC : National Institute of Environmental Health Sciences, 1994,
— id: 1219, year: 1994, vol: , page: , stat: ,

Crystalline Ni3S2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein
Huang X; Klein CB; Costa M
1994 Mar;15(3):545-548, Carcinogenesis
— id: 6409, year: 1994, vol: 15, page: 545, stat: Journal Article,

The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis
Huang X; Zhuang Z; Frenkel K; Klein CB; Costa M
1994 Sep;102 Suppl 3:281-284, Environmental health perspectives
— id: 6647, year: 1994, vol: 102 Suppl 3, page: 281, stat: Journal Article,

Metal mutagenesis in transgenic Chinese hamster cell lines
Klein CB; Kargacin B; Su L; Cosentino S; Snow ET; Costa M
1994 Sep;102 Suppl 3:63-67, Environmental health perspectives
— id: 6661, year: 1994, vol: 102 Suppl 3, page: 63, stat: Journal Article,

Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles
Lin X; Costa M
1994 Sep;102 Suppl 3:289-292, Environmental health perspectives
— id: 6682, year: 1994, vol: 102 Suppl 3, page: 289, stat: Journal Article,

Nickel-induced transformation of human cells causes loss of the phosphorylation of the retinoblastoma protein
Lin X; Dowjat WK; Costa M
1994 May 15;54(10):2751-2754, Cancer research
— id: 6440, year: 1994, vol: 54, page: 2751, stat: Journal Article,

Loss of thrombospondin transcriptional activity in nickel-transformed cells
Salnikow K; Cosentino S; Klein C; Costa M
1994 Jan;14(1):851-858, Molecular & cellular biology
— id: 6507, year: 1994, vol: 14, page: 851, stat: Journal Article,

Altered oxidative stress responses in nickel-resistant mammalian cells
Salnikow K; Gao M; Voitkun V; Huang X; Costa M
1994 Dec 15;54(24):6407-6412, Cancer research
— id: 6738, year: 1994, vol: 54, page: 6407, stat: Journal Article,

The loss of thrombospondin expression in Ni-resistant and Ni-transformed cells
Salnikow K; Wang S; Gao M; Klein C; Costa M
1994 ;35:A1122-A1122, Proceedings of the annual meeting of the American Association for Cancer Research
— id: 6019, year: 1994, vol: 35, page: A1122, stat: Journal Article,

EFFECT OF THE RB ON THROMBOSPONDIN TRANSCRIPTION IN NORMAL AND NICKEL-TRANSFORMED CELLS
SALNIKOW, K; COSTA, M
1994 FEB 13 ;15(3):192-192, Journal of cellular biochemistry
— id: 52508, year: 1994, vol: 15, page: 192, stat: Journal Article,

Application of reliability models to studies of biomarker validation
Taioli E; Kinney P; Zhitkovich A; Fulton H; Voitkun V; Cosma G; Frenkel K; Toniolo P; Garte S; Costa M
1994 Mar;102(3):306-309, Environmental health perspectives
— id: 10381, year: 1994, vol: 102, page: 306, stat: Journal Article,

Complexing of amino acids to DNA by chromate in intact cells
Voitkun V; Zhitkovich A; Costa M
1994 Sep;102 Suppl 3:251-255, Environmental health perspectives
— id: 6768, year: 1994, vol: 102 Suppl 3, page: 251, stat: Journal Article,

Development of an 125I-postlabeling assay as a simple, rapid, and sensitive index of DNA-protein cross-links
Zhuang Z; Costa M
1994 Sep;102 Suppl 3:301-304, Environmental health perspectives
— id: 6796, year: 1994, vol: 102 Suppl 3, page: 301, stat: Journal Article,

Protein oxidation and amino acid-DNA crosslinking by nickel compounds in intact cultured cells
Zhuang Z; Huang X; Costa M
1994 Jun;126(2):319-325, Toxicology & applied pharmacology
— id: 6563, year: 1994, vol: 126, page: 319, stat: Journal Article,

Mechanisms of chromium carcinogenicity and toxicity
Cohen MD; Kargacin B; Klein CB; Costa M
1993 ;23(3):255-281, Critical reviews in toxicology
— id: 6337, year: 1993, vol: 23, page: 255, stat: Journal Article,

Molecular targets of nickel and chromium in human and experimental systems
Costa M
1993 ;19 Suppl 1:71-74, Scandinavian journal of work environment & health
— id: 6342, year: 1993, vol: 19 Suppl 1, page: 71, stat: Journal Article,

Preliminary report on a simple new assay for DNA-protein cross-links as a biomarker of exposures experienced by welders
Costa M; Zhitkovich A; Taioli E; Toniolo P
1993 Oct-Nov;40(2-3):217-222, Journal of toxicology & environmental health
— id: 6343, year: 1993, vol: 40, page: 217, stat: Journal Article,

DNA-protein cross-links in welders: molecular implications
Costa M; Zhitkovich A; Toniolo P
1993 Feb 1;53(3):460-463, Cancer research
— id: 10386, year: 1993, vol: 53, page: 460, stat: Journal Article,

Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence
Huang X; Frenkel K; Klein CB; Costa M
1993 May;120(1):29-36, Toxicology & applied pharmacology
— id: 10384, year: 1993, vol: 120, page: 29, stat: Journal Article,

Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanine phosphoribosyl transferase locus
Kargacin B; Klein CB; Costa M
1993 Jun;300(1):63-72, Mutation research
— id: 10383, year: 1993, vol: 300, page: 63, stat: Journal Article,

COMPARISON OF THE UPTAKE AND DISTRIBUTION OF CHROMATE IN RATS AND MICE
KARGACIN, B; SQUIBB, KS; COSENTINO, S; ZHITKOVICH, A; COSTA, M
1993 MAR ;36(3):307-318, Biological trace element research
— id: 54334, year: 1993, vol: 36, page: 307, stat: Journal Article,

Development and utilization of a new simple assay for DNA-protein crosslinks as a biomarker of exposure to welding fumes
Toniolo P; Zhitkovich A; Costa M
1993 ;65(1 Suppl):S87-S89, International archives of occupational & environmental health
— id: 6540, year: 1993, vol: 65, page: S87, stat: Journal Article,

Trace elements : alumninum, arsenic, cadmium, mercury and nickel
Bhamra RK; Costa M
Environmental toxicants : human exposures and their health effects New York : Van Nostrand Reinhold, 1992,
— id: 4412, year: 1992, vol: , page: 575, stat: Chapter,

Chromium compounds
Cohen MD; Costa M
Environmental and occupational medicine Boston : Little Brown, 1992,
— id: 4413, year: 1992, vol: , page: 799, stat: Chapter,

Forward mutations and DNA-protein crosslinks induced by ammonium metavanadate in cultured mammalian cells
Cohen MD; Klein CB; Costa M
1992 Sep;269(1):141-148, Mutation research
— id: 13468, year: 1992, vol: 269, page: 141, stat: Journal Article,

Deletion of a senescence gene as a mechanism of nickel carcinogenesis
Costa M
1992 ;4(Special Supplement):481-485, Chemical speciation & bioavailability
— id: 72790, year: 1992, vol: 4, page: 481, stat: Journal Article,

Involvement of heterochromatin damage in nickel-induced transformation and resistance
Costa M; Conway K; Imbra R; Wang XW
Nickel and human health : current perspectives New York : Wiley, 1992,
— id: 4415, year: 1992, vol: , page: 295, stat: Chapter,

Analysis of residual amino acid--DNA crosslinks induced in intact cells by nickel and chromium compounds
Lin X; Zhuang Z; Costa M
1992 Oct;13(10):1763-1768, Carcinogenesis
— id: 10393, year: 1992, vol: 13, page: 1763, stat: Journal Article,

Analysis of the binding sites of chromium to DNA and protein in vitro and in intact cells
Salnikow K; Zhitkovich A; Costa M
1992 Dec;13(12):2341-2346, Carcinogenesis
— id: 10392, year: 1992, vol: 13, page: 2341, stat: Journal Article,

Nickel and nickel carcinogenesis
Snow ET; Costa M
Environmental and occupational medicine Boston : Little Brown, 1992,
— id: 4414, year: 1992, vol: , page: 807, stat: Chapter,

POTENTIATION OF SODIUM CHROMATE(VI)-INDUCED CHROMOSOMAL-ABERRATIONS AND MUTATION BY VITAMIN-B2 IN CHINESE-HAMSTER V79-CELLS
SUGIYAMA, M; TSUZUKI, K; LIN, XH; COSTA, M
1992 NOV ;283(3):211-214, Mutation research. DNA repair
— id: 51832, year: 1992, vol: 283, page: 211, stat: Journal Article,

A conserved region in human and Chinese hamster X chromosomes can induce cellular senescence of nickel-transformed Chinese hamster cell lines
Wang XW; Lin X; Klein CB; Bhamra RK; Lee YW; Costa M
1992 Apr;13(4):555-561, Carcinogenesis
— id: 13643, year: 1992, vol: 13, page: 555, stat: Journal Article,

A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo
Zhitkovich A; Costa M
1992 Aug;13(8):1485-1489, Carcinogenesis
— id: 8420, year: 1992, vol: 13, page: 1485, stat: Journal Article,

Alteration in restriction enzyme digestion patterns detects DNA--protein complexes induced by chromate
Chen Y; Cohen MD; Snow ET; Costa M
1991 Sep;12(9):1575-1580, Carcinogenesis
— id: 13934, year: 1991, vol: 12, page: 1575, stat: Journal Article,

Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate
Coogan TP; Motz J; Snyder CA; Squibb KS; Costa M
1991 Jun 1;109(1):60-72, Toxicology & applied pharmacology
— id: 14000, year: 1991, vol: 109, page: 60, stat: Journal Article,

Distribution of chromium within cells of the blood
Coogan TP; Squibb KS; Motz J; Kinney PL; Costa M
1991 Mar 15;108(1):157-166, Toxicology & applied pharmacology
— id: 14097, year: 1991, vol: 108, page: 157, stat: Journal Article,

DNA-protein complexes induced by chromate and other carcinogens
Costa M
1991 May;92:45-52, Environmental health perspectives
— id: 14041, year: 1991, vol: 92, page: 45, stat: Journal Article,

Molecular mechanisms of nickel carcinogenesis
Costa M
1991 ;31:321-337, Annual review of pharmacology & toxicology
— id: 14156, year: 1991, vol: 31, page: 321, stat: Journal Article,

DNA damage by mercury compounds : an overview
Costa M; Christie NT; Cantoni O; Zelikoff JT; Wang XW; Rossman TG
Advances in mercury toxicology New York : Plenum Press, 1991,
— id: 4397, year: 1991, vol: , page: ?, stat: Chapter,

Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control
Klein CB; Conway K; Wang XW; Bhamra RK; Lin XH; Cohen MD; Annab L; Barrett JC; Costa M
1991 Feb 15;251(4995):796-799, Science
— id: 8211, year: 1991, vol: 251, page: 796, stat: Journal Article,

The role of oxidative processes in metal carcinogenesis
Klein CB; Frenkel K; Costa M
1991 Nov-Dec;4(6):592-604, Chemical research in toxicology
— id: 13852, year: 1991, vol: 4, page: 592, stat: Journal Article,

DIFFERENCES IN THE EFFECT OF VITAMIN-E ON NICKEL SULFIDE OR NICKEL CHLORIDE-INDUCED CHROMOSOMAL-ABERRATIONS IN MAMMALIAN- CELLS
Lin, XH; Sugiyama, M; Costa, M
1991 Jun;260(2):159-164, Mutation research. DNA repair
— id: 32170, year: 1991, vol: 260, page: 159, stat: Journal Article,

Complexing of actin and other nuclear proteins to DNA by cis-diamminedichloroplatinum(II) and chromium compounds
Miller CA 3d; Cohen MD; Costa M
1991 Feb;12(2):269-276, Carcinogenesis
— id: 14136, year: 1991, vol: 12, page: 269, stat: Journal Article,

PROTECTIVE EFFECT OF VITAMIN-E AGAINST CHROMOSOMAL-ABERRATIONS AND MUTATION INDUCED BY SODIUM CHROMATE IN CHINESE-HAMSTER V79 CELLS
Sugiyama, M; Lin, XH; Costa, M
1991 May;260(1):19-23, Mutation research. DNA repair
— id: 32181, year: 1991, vol: 260, page: 19, stat: Journal Article,

Changes in protein phosphorylation in wild-type and nickel-resistant cells and their involvement in morphological elongation
Wang XW; Costa M
1991 ;4(4):201-206, Biology of metals
— id: 14236, year: 1991, vol: 4, page: 201, stat: Journal Article,

A blotting method for monitoring the formation of chemically induced DNA-protein complexes
Cohen MD; Miller CA; Xu LS; Snow ET; Costa M
1990 Apr;186(1):1-7, Analytical biochemistry
— id: 36437, year: 1990, vol: 186, page: 1, stat: Journal Article,

The detection of DNA-protein complexes in vitro by an immunological assay
Cosma, G N; Miller, C A 3rd; Costa, M
1990 ;4(1):17-22, Toxicology in vitro
— id: 111599, year: 1990, vol: 4, page: 17, stat: Journal Article,

Analysis of DNA-protein complexes induced by chemical carcinogens
Costa M
1990 Nov;44(3):127-135, Journal of cellular biochemistry
— id: 14311, year: 1990, vol: 44, page: 127, stat: Journal Article,

DELETION OF A SENESCENCE TUMOR SUPPRESSOR GENE AS A MECHANISM OF NICKEL CARCINOGENESIS
Costa, M
1990 Apr 22;199(3):25CHAS-, Abstracts of papers (American Chemical Society)
— id: 31950, year: 1990, vol: 199, page: 25CHAS, stat: Journal Article,

IMMUNODETECTION OF DNA PROTEIN CROSS-LINKS BY SLOT BLOTTING
Miller, CA; Costa, M
1990 Apr;234(2):97-106, Mutation research. DNA repair
— id: 32089, year: 1990, vol: 234, page: 97, stat: Journal Article,

Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells
Conway K; Costa M
1989 Nov 1;49(21):6032-6038, Cancer research
— id: 10435, year: 1989, vol: 49, page: 6032, stat: Journal Article,

The involvement of heterochromatic damage in nickel-induced transformation
Conway K; Costa M
1989 Jul-Sep;21:437-444, Biological trace element research
— id: 10576, year: 1989, vol: 21, page: 437, stat: Journal Article,

Toxicity and carcinogenicity of nickel compounds [published erratum appears in Crit Rev Toxicol 1989;20(2):135]
Coogan TP; Latta DM; Snow ET; Costa M
1989 ;19(4):341-384, Critical reviews in toxicology
— id: 10790, year: 1989, vol: 19, page: 341, stat: Journal Article,

Perspectives on the mechanism of nickel carcinogenesis gained from models of in vitro carcinogenesis
Costa M
1989 May;81:73-76, Environmental health perspectives
— id: 10647, year: 1989, vol: 81, page: 73, stat: Journal Article,

Proceedings of the First International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogensis, hedl Sept 19-22, 1988 in Urbino, Italy
Costa, Max; Rossman, Toby
Clifton NJ : Humana Press, 1989,
— id: 1218, year: 1989, vol: , page: , stat: ,

Characterization of a nickel resistant mouse cell line
Imbra RJ; Wang XW; Costa M
1989 Jul-Sep;21:97-103, Biological trace element research
— id: 10574, year: 1989, vol: 21, page: 97, stat: Journal Article,

STUDIES ON THE MECHANISM OF NICKEL-INDUCED HETEROCHROMATIN DAMAGE - EFFECT ON SPECIFIC DNA-PROTEIN INTERACTIONS
Imbra, RJ; Latta, DM; Costa, M
1989 Oct;22(1-4):167-179, Toxicological & environmental chemistry
— id: 31617, year: 1989, vol: 22, page: 167, stat: Journal Article,

Analysis of proteins cross-linked to DNA after treatment of cells with formaldehyde, chromate, and cis-diamminedichloroplatinum(II)
Miller CA 3d; Costa M
1989 Winter;2(1):11-26, Molecular toxicology
— id: 10811, year: 1989, vol: 2, page: 11, stat: Journal Article,

Immunological detection of DNA-protein complexes induced by chromate
Miller CA 3d; Costa M
1989 Apr;10(4):667-672, Carcinogenesis
— id: 10687, year: 1989, vol: 10, page: 667, stat: Journal Article,

THE PROCEEDINGS OF THE 1ST INTERNATIONAL MEETING ON MOLECULAR MECHANISMS OF METAL TOXICITY AND CARCINOGENICITY, HELD SE
ROSSMAN, TG; COSTA, M
1989 ;21(1-4):R1-R2, Biological trace element research
— id: 104619, year: 1989, vol: 21, page: R1, stat: Journal Article,

Alteration of nickel-binding proteins in nickel-resistant cells
Wang XW; Costa M
1989 ;1(6):351-358, Cancer communications
— id: 10778, year: 1989, vol: 1, page: 351, stat: Journal Article,

Chromosomal alterations in cell lines derived from mouse rhabdomyosarcomas induced by crystalline nickel sulfide
Christie NT; Sen P; Costa M
1988 ;1(1):43-50, Biology of metals
— id: 11256, year: 1988, vol: 1, page: 43, stat: Journal Article,

TRANSFORMATION OF CHINESE-HAMSTER EMBRYO CELLS BY NICKEL YIELDS CELL-LINES WITH ALTERED HETEROCHROMATIC STAINING PATTERNS
Conway, K; Costa, M
1988 Mar;29(5):117-117, Proceedings (American Association for Cancer Research)
— id: 31480, year: 1988, vol: 29, page: 117, stat: Journal Article,

EFFECT OF NICKEL(II) ON DNA-PROTEIN INTERACTIONS
Coogan, TP; Latta, DM; Imbra, RJ; Costa, M
1988 Mar;29(5):87-87, Proceedings (American Association for Cancer Research)
— id: 31478, year: 1988, vol: 29, page: 87, stat: Journal Article,

The role of trace metals in carcinogenesis
Costa, Max; Creasey, William A
[Bethesda MD] : US Dept of Health and Human Services. International Cancer Research Data Bank, 1988,
— id: 1217, year: 1988, vol: , page: , stat: ,

Characterization of DNA-protein complexes induced in intact cells by the carcinogen chromate
Miller CA 3d; Costa M
1988 ;1(2):125-133, Molecular carcinogenesis
— id: 11257, year: 1988, vol: 1, page: 125, stat: Journal Article,

CHANGES IN NUCLEAR PROTEIN-DNA INTERACTION CAUSED BY POTASSIUM CHROMATE
MILLER, CA; COSTA, M
1988 MAR ;29(3-4):112-112, Proceedings (American Association for Cancer Research)
— id: 98523, year: 1988, vol: 29, page: 112, stat: Journal Article,

Stimulation of polyadenosine diphosphoribose synthesis by DNA lesions induced by sodium chromate in Chinese hamster V-79 cells
Sugiyama, M; Costa, M; Nakagawa, T; Hidaka, T; Ogura, R
1988 Mar 1;48(5):1100-1104, Cancer research
— id: 141422, year: 1988, vol: 48, page: 1100, stat: Journal Article,

Characterization of mouse cell lines resistant to nickel(II) ions
Wang XW; Imbra RJ; Costa M
1988 Dec 1;48(23):6850-6854, Cancer research
— id: 10871, year: 1988, vol: 48, page: 6850, stat: Journal Article,

Genetic toxicology of lead compounds
Zelikoff JT; Li JH; Hartwig A; Wang XW; Costa M; Rossman TG
1988 Oct;9(10):1727-1732, Carcinogenesis
— id: 10946, year: 1988, vol: 9, page: 1727, stat: Journal Article,

Effect of magnesium on nickel-induced genotoxicity and cell transformation
Conway, K; Wang, X W; Xu, L S; Costa, M
1987 Aug;8(8):1115-1121, Carcinogenesis
— id: 141423, year: 1987, vol: 8, page: 1115, stat: Journal Article,

Principles of industrial toxicology
Costa, M
1987 Jul;4(3):559-570, Clinics in podiatric medicine & surgery
— id: 111579, year: 1987, vol: 4, page: 559, stat: Journal Article,

EFFECTS OF CHROMATE AND NICKEL ON DNA-PROTEIN INTERACTIONS
Costa, M; Imbra, RJ; Miller, CA; Ashkenazikimmel, T; Latta, DM
1987 Mar;28(3):89-89, Proceedings (American Association for Cancer Research)
— id: 31214, year: 1987, vol: 28, page: 89, stat: Journal Article,

Effects of nickel(II) on nuclear protein binding to DNA in intact mammalian cells
Patierno, S R; Costa, M
1987 May;9(2):113-126, Cancer biochemistry biophysics
— id: 141426, year: 1987, vol: 9, page: 113, stat: Journal Article,

Effect of nickel(II) on DNA-protein binding, thymidine incorporation, and sedimentation pattern of chromatin fractions from intact mammalian cells
Patierno, S R; Sugiyama, M; Costa, M
1987 Spring;2:13-23, Journal of biochemical toxicology
— id: 141427, year: 1987, vol: 2, page: 13, stat: Journal Article,

Comparison of the localization of chromosome damage induced by calcium chromate and nickel compounds
Sen, P; Conway, K; Costa, M
1987 Apr 15;47(8):2142-2147, Cancer research
— id: 141424, year: 1987, vol: 47, page: 2142, stat: Journal Article,

Physicochemical characteristics and biological effects of nickel oxides
Sunderman, F W Jr; Hopfer, S M; Knight, J A; McCully, K S; Cecutti, A G; Thornhill, P G; Conway, K; Miller, C; Patierno, S R; Costa, M
1987 Feb;8(2):305-313, Carcinogenesis
— id: 141425, year: 1987, vol: 8, page: 305, stat: Journal Article,

Assessment of the uptake and mutagenicity of nickel chloride in salmonella tester strains
Biggart, N W; Costa, M
1986 Dec;175(4):209-215, Mutation research
— id: 141434, year: 1986, vol: 175, page: 209, stat: Journal Article,

Differences in the effects of Hg(II) on DNA repair induced in Chinese hamster ovary cells by ultraviolet or X-rays
Christie, N T; Cantoni, O; Sugiyama, M; Cattabeni, F; Costa, M
1986 Feb;29(2):173-178, Molecular pharmacology
— id: 133270, year: 1986, vol: 29, page: 173, stat: Journal Article,

Antagonistic effect of magnesium chloride on the nickel chloride-induced inhibition of DNA replication in Chinese hamster ovary cells
Conway, K; Sen, P; Costa, M
1986 Jun;1(2):11-25, Journal of biochemical toxicology
— id: 133266, year: 1986, vol: 1, page: 11, stat: Journal Article,

Metal ion carcinogenesis: mechanistic aspects
Costa M; Heck JD
1986 ;20:259-278, Metal ions in biological systems
— id: 72788, year: 1986, vol: 20, page: 259, stat: Journal Article,

Methods for the in vitro assessment of metal ion toxicity
Heck JD; Costa M
1986 ;20:279-303, Metal ions in biological systems
— id: 72789, year: 1986, vol: 20, page: 279, stat: Journal Article,

Pathway of nickel uptake influences its interaction with heterochromatic DNA
Sen, P; Costa, M
1986 Jun 30;84(2):278-285, Toxicology & applied pharmacology
— id: 133269, year: 1986, vol: 84, page: 278, stat: Journal Article,

Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells
Sugiyama, M; Patierno, S R; Cantoni, O; Costa, M
1986 Jun;29(6):606-613, Molecular pharmacology
— id: 141428, year: 1986, vol: 29, page: 606, stat: Journal Article,

Comparison of DNA lesions and cytotoxicity induced by calcium chromate in human, mouse, and hamster cell lines
Sugiyama, M; Wang, X W; Costa, M
1986 Sep;46(9):4547-4551, Cancer research
— id: 133267, year: 1986, vol: 46, page: 4547, stat: Journal Article,

DNA-protein cross-links induced by nickel compounds in intact cultured mammalian cells
Patierno, S R; Costa, M
1985 Oct;55(1-2):75-91, Chemico-biological interactions
— id: 141430, year: 1985, vol: 55, page: 75, stat: Journal Article,

Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin
Patierno, S R; Sugiyama, M; Basilion, J P; Costa, M
1985 Nov;45(11 Pt 2):5787-5794, Cancer research
— id: 141429, year: 1985, vol: 45, page: 5787, stat: Journal Article,

Characterization of DNA lesions produced by HgCl2 in cell culture systems
Cantoni, O; Christie, N T; Robison, S H; Costa, M
1984 Apr;49(1-2):209-224, Chemico-biological interactions
— id: 519022, year: 1984, vol: 49, page: 209, stat: Journal Article,

Mechanism of HgCl2 cytotoxicity in cultured mammalian cells
Cantoni, O; Christie, N T; Swann, A; Drath, D B; Costa, M
1984 Sep;26(2):360-368, Molecular pharmacology
— id: 519002, year: 1984, vol: 26, page: 360, stat: Journal Article,

Use of mammalian DNA repair-deficient mutants to assess the effects of toxic metal compounds on DNA
Christie, N T; Cantoni, O; Evans, R M; Meyn, R E; Costa, M
1984 May;33(10):1661-1670, Biochemical pharmacology
— id: 519012, year: 1984, vol: 33, page: 1661, stat: Journal Article,

In vitro assessment of the toxicity of metal compounds : IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA
Christie, N T; Costa, M
1984 Apr;6(2):139-158, Biological trace element research
— id: 885752, year: 1984, vol: 6, page: 139, stat: Journal Article,

Perspectives on the mechanism of nickel carcinogenesis
Costa M; Heck JD
1984 ;6:285-309, Advances in inorganic biochemistry
— id: 72787, year: 1984, vol: 6, page: 285, stat: Journal Article,

Toxicity and carcinogenicity of essential and non-essential metals
Costa M; Kraker AJ; Patierno SR
1984 ;1:1-49, Progress in clinical biochemistry & medicine
— id: 72786, year: 1984, vol: 1, page: 1, stat: Journal Article,

In vitro assessment of the toxicity of metal compounds : III. Effects of metals on DNA structure and function in intact cells
Christie, N T; Costa, M
1983 Feb;5(1):55-71, Biological trace element research
— id: 885762, year: 1983, vol: 5, page: 55, stat: Journal Article,

Growth inhibition and metallothionein induction in cadmium-resistant cells by essential and non-essential metals
Evans, R M; Patierno, S R; Wang, D S; Cantoni, O; Costa, M
1983 Jul;24(1):77-83, Molecular pharmacology
— id: 141431, year: 1983, vol: 24, page: 77, stat: Journal Article,

Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents
Patierno, S R; Costa, M; Lewis, V M; Peavy, D L
1983 Apr;130(4):1924-1929, Journal of immunology (1950)
— id: 141433, year: 1983, vol: 130, page: 1924, stat: Journal Article,

Application of a modified 203Hg binding assay for metallothionein
Patierno, S R; Pellis, N R; Evans, R M; Costa, M
1983 Apr 4;32(14):1629-1636, Life sciences
— id: 141432, year: 1983, vol: 32, page: 1629, stat: Journal Article,

Comparison of protein, RNA, and DNA binding and cell-cycle-specific growth inhibitory effects of nickel compounds in cultured cells
Harnett, P B; Robison, S H; Swartzendruber, D E; Costa, M
1982 Jun 15;64(1):20-30, Toxicology & applied pharmacology
— id: 141437, year: 1982, vol: 64, page: 20, stat: Journal Article,

Factors influencing the phagocytosis, neoplastic transformation, and cytotoxicity of particulate nickel compounds in tissue culture systems
Costa, M; Abbracchio, M P; Simmons-Hansen, J
1981 Sep 15;60(2):313-323, Toxicology & applied pharmacology
— id: 141438, year: 1981, vol: 60, page: 313, stat: Journal Article,

Biochemical and morphological transformation of hamster embryo cells in tissue culture by specific metal compounds
Costa M
Molecular basis of environmental toxicity Ann Arbor MI : Ann Arbor Science, 1980,
— id: 4410, year: 1980, vol: , page: 373, stat: Chapter,

Metal carcinogenesis in tissue culture systems
Costa M; Jones MK; Lindberg O
1980 ;140:45-73, ACS symposium series
— id: 72785, year: 1980, vol: 140, page: 45, stat: Journal Article,

Phagocytosis of particulate nickel compounds is related to their carcinogenic activity
Costa M; Mollenhauer HH
Nickel toxicology London : Academic Press, 1980,
— id: 4411, year: 1980, vol: , page: 43, stat: Chapter,

Metal carcinogenesis testing : principles and in vitro methods
Costa, Max
Clifton NJ : Humana Press, 1980,
— id: 1216, year: 1980, vol: , page: , stat: ,

Preliminary report on nickel-induced transformation in tissue culture
Costa M
Ultratrace metal analysis in biological sciences and environment : a symposium Washington DC : American Chemical Society, 1979,
— id: 4409, year: 1979, vol: , page: 73, stat: Chapter,

Regulation of cAMP-dependent protein kinases by endogenous heat stable inhibitor(s)
Costa M
Proteases and hormones New York : Elsevier, 1979,
— id: 4408, year: 1979, vol: , page: 159, stat: Chapter,

Alteration in morphology of chinese hamster ovary cells by Ni3S2 and dibutyryl cAMP
Costa, M
1978 Jun;44(3):555-566, Toxicology & applied pharmacology
— id: 141439, year: 1978, vol: 44, page: 555, stat: Journal Article,

[Polarographic study of the effect of verapamil on respiratory activity and oxidative phosphorylation of mitochondria]
Rodrigues, L E; Pinto, R S; Costa, M
1978 Feb;31 Suppl 1:15-18, Arquivos brasileiros de cardiologia
— id: 99555, year: 1978, vol: 31 Suppl 1, page: 15, stat: Journal Article,

Cyclic AMP and cyclic AMP-dependent protein kinase in cell growth processes
Costa, Max
[S.l. : s.n.], 1976,
— id: 1220, year: 1976, vol: , page: , stat: ,