James A Borowiec

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James A Borowiec, Ph.D.

Professor;
Department of Biochemistry and Molecular Pharmacology

Contact Info

Address
550 First Avenue
Dept. of Biochemistry Floor 3 Room 359
Medical Science Building
New York, NY 10016

212-263-8453, 212-263-8454
212-263-8166
James.Borowiec@nyumc.org

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Education

1980-1986 — University of California at Los Angeles, PhD in Biochemistry, Graduate Education
1986-1989 — Memorial Sloan-Kettering Cancer Center with Dr. Jerard Hurwitz, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery
Murphy, Anar K; Fitzgerald, Michael; Ro, Teresa; Kim, Jee Hyun; Rabinowitsch, Ariana I; Chowdhury, Dipanjan; Schildkraut, Carl L; Borowiec, James A
2014 Aug;206(4):493-507, Journal of cell biology
— id: 1131922, year: 2014, vol: 206, page: 493, stat: Journal Article,

Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination
Bhatt, Purvi; d'Avout, Claire; Kane, Naomi S; Borowiec, James A; Saxena, Anjana
2012 Feb;279(3):370-383, FEBS journal
— id: 149953, year: 2012, vol: 279, page: 370, stat: Journal Article,

Open Sesame: activating dormant replication origins in the mouse immunoglobulin heavy chain (Igh) locus
Borowiec, James A; Schildkraut, Carl L
2011 Jun;23(3):284-292, Current opinion in cell biology
— id: 134310, year: 2011, vol: 23, page: 284, stat: Journal Article,

Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress
Brocardo, Mariana G; Borowiec, James A; Henderson, Beric R
2011 Sep;43(9):1354-1364, International journal of biochemistry & cell biology
— id: 638772, year: 2011, vol: 43, page: 1354, stat: Journal Article,

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
Lee, Dong-Hyun; Pan, Yunfeng; Kanner, Shlomo; Sung, Patrick; Borowiec, James A; Chowdhury, Dipanjan
2010 Mar;17(3):365-372, Nature structural & molecular biology
— id: 638782, year: 2010, vol: 17, page: 365, stat: Journal Article,

Single molecule analysis demonstrates that RPA phosphorylation is necessary for efficient fork movement during replication stress
Murphy, A K; Borowiec, J; Schildkraut, C L
2010 15 Dec 2010;21(24):-, Molecular biology of the cell
— id: 157729, year: 2010, vol: 21, page: , stat: Journal Article,

Mitotic crisis: the unmasking of a novel role for RPA
Anantha, Rachel William; Borowiec, James A
2009 Feb 1;8(3):357-361, Cell cycle
— id: 95184, year: 2009, vol: 8, page: 357, stat: Journal Article,

Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress
Vassin, Vitaly M; Anantha, Rachel William; Sokolova, Elena; Kanner, Shlomo; Borowiec, James A
2009 Nov 15;122(Pt 22):4070-4080, Journal of cell science
— id: 104802, year: 2009, vol: 122, page: 4070, stat: Journal Article,

RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage
Anantha, Rachel William; Sokolova, Elena; Borowiec, James A
2008 Sep 2;105(35):12903-12908, Proceedings of the National Academy of Sciences of the United States of America
— id: 87807, year: 2008, vol: 105, page: 12903, stat: Journal Article,

Sequential and synergistic modification of human Replication Factor A stimulates chromosomal DNA repair
Anantha, Rachel W; Vassin, Vitaly M; Borowiec, James A
2007 Dec 7;282(49):35910-35923, Journal of biological chemistry
— id: 74674, year: 2007, vol: 282, page: 35910, stat: Journal Article,

Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization
Saxena, A; Rorie, C J; Dimitrova, D; Daniely, Y; Borowiec, J A
2006 Nov 23;25(55):7274-7288, Oncogene
— id: 69575, year: 2006, vol: 25, page: 7274, stat: Journal Article,

Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation
Kim, Kyung; Dimitrova, Diana D; Carta, Kristine M; Saxena, Anjana; Daras, Mariza; Borowiec, James A
2005 Mar;25(6):2463-2474, Molecular & cellular biology
— id: 48733, year: 2005, vol: 25, page: 2463, stat: Journal Article,

The Toposome: A New Twist on Topoisomerase IIalpha
Borowiec, James A
2004 May;3(5):627-628, Cell cycle
— id: 42686, year: 2004, vol: 3, page: 627, stat: Journal Article,

Replication protein A (RPA) phosphorylation prevents RPA association with replication centers
Vassin, Vitaly M; Wold, Marc S; Borowiec, James A
2004 Mar;24(5):1930-1943, Molecular & cellular biology
— id: 42117, year: 2004, vol: 24, page: 1930, stat: Journal Article,

Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation
Daniely, Yaron; Dimitrova, Diana D; Borowiec, James A
2002 Aug;22(16):6014-6022, Molecular & cellular biology
— id: 32273, year: 2002, vol: 22, page: 6014, stat: Journal Article,

Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replication
Daniely Y; Borowiec JA
2000 May 15;149(4):799-810, Journal of cell biology
— id: 11696, year: 2000, vol: 149, page: 799, stat: Journal Article,

5' --> 3' molecular polarity of human replication protein A (hRPA) binding to pseudo-origin DNA substrates
Iftode C; Borowiec JA
2000 Oct 3;39(39):11970-11981, Biochemistry
— id: 17118, year: 2000, vol: 39, page: 11970, stat: Journal Article,

Replication protein A (RPA): the eukaryotic SSB
Iftode C; Daniely Y; Borowiec JA
1999 ;34(3):141-180, Critical reviews in biochemistry & molecular biology
— id: 6191, year: 1999, vol: 34, page: 141, stat: Journal Article,

Distinct roles of two binding sites for the bovine papillomavirus (BPV) E2 transactivator on BPV DNA replication
Gillette TG; Borowiec JA
1998 Jul;72(7):5735-5744, Journal of virology
— id: 8266, year: 1998, vol: 72, page: 5735, stat: Journal Article,

Unwinding of origin-specific structures by human replication protein A occurs in a two-step process
Iftode C; Borowiec JA
1998 Dec 15;26(24):5636-5643, Nucleic acids research
— id: 7355, year: 1998, vol: 26, page: 5636, stat: Journal Article,

Synthetic DNA replication bubbles bound and unwound with twofold symmetry by a simian virus 40 T-antigen double hexamer
Smelkova NV; Borowiec JA
1998 Nov;72(11):8676-8681, Journal of virology
— id: 7449, year: 1998, vol: 72, page: 8676, stat: Journal Article,